CN105233119A - Traditional Chinese medicine composition enhancing body immunity of middle-aged and aged people and preparation method thereof - Google Patents

Traditional Chinese medicine composition enhancing body immunity of middle-aged and aged people and preparation method thereof Download PDF

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CN105233119A
CN105233119A CN201510605594.3A CN201510605594A CN105233119A CN 105233119 A CN105233119 A CN 105233119A CN 201510605594 A CN201510605594 A CN 201510605594A CN 105233119 A CN105233119 A CN 105233119A
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张士舜
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Abstract

A traditional Chinese medicine composition enhancing body immunity of middle-aged and aged people comprises, by weight, 1-5 parts of manyflower solomonseal rhizome, 1-5 parts of fragrant solomonseal rhizome, 1-5 parts of emblic leafflower fruit, 1-3 parts of Chinese date, 1-5 parts of dried longan pulp, 5-15 parts of Chinese wolfberry fruit, 1-5 parts of Agaricus blazei, 1-5 parts of seed of Hovenia acerba, 0-4 parts of smoked plum, 0-5 parts of mulberry fruit, 0-6 parts of hawthorn fruit, 0-4 parts of raspberry fruit, 1-5 parts of fruit of Siraitia grosvenorii, 1-5 parts of sharpleaf galangal fruit, 1-5 parts of ginseng, 1-5 parts of lily bulb, and 1-5 parts of Indian bread. Preferably, the traditional Chinese medicine composition also comprises, by weight, 1-5 parts of a sweetener. The traditional Chinese medicine composition can be made into traditional Chinese medicine beverages, granules, powders and medical liquors; the raw materials are natural, the taste is good, and the composition may enhance body strength, lower blood sugar, tonify the liver and kidney and improve body immunity, is effective in curing diseases and conditioning, is never hard to swallow due to bitter taste, is suitable for people with low immunity, especially old people to take for a long time, and has no side effect.

Description

A kind ofly strengthen Chinese medicine composition of middle-aged and elderly people immunity of organisms and preparation method thereof
Technical field
The invention belongs to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms.
Background technology
Immunity is the defense mechanism of human body self, be human bioequivalence and eliminate any foreign body of external intrusion as virus, antibacterial etc., process is old and feeble, damage, death, the ability of mutant cell and virus infected cell in the own cells of degeneration and identification and handling body.People in life, immunity contends with the aging course of infectious disease, noninfectious, tumor and body all the time.Aging be everyone must faced by life experience, from the age, middle-aged and elderly people has entered the body aging phase, body function is progressively weak, often feel the discomfort of kidney, the heart, spleen, lung and liver significantly, the every hypofunction of old people's health, also can cause immunity degradation, so the general disease caused in the face of hypoimmunity of middle-aged and elderly people, clinical manifestation is insomnia night sweat, soreness of the waist and knees, lassitude and weak, upset, easy catching a cold, senile plaque etc.There is mouthfeel difference and the slow shortcoming that takes effect in current Chinese medicine preparation, is not suitable for the daily health caring beverage becoming middle-aged and elderly people.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of raw material natural, mouthfeel is good, low price, can physical strength reinforcing, reduce blood glucose, invigorating the liver and kidney, improve a kind of Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms of immunity of organisms, the existing merit except disease conditioning, the fraud of tasteless suffering pharynx again, is applicable to immunocompromised person's especially middle-aged and elderly people long-term taking, has no side effect.
Technical scheme of the present invention is:
Strengthen a Chinese medicine composition for middle-aged and elderly people immunity of organisms, it is characterized in that it comprises the raw material components of following parts by weight: Rhizoma Polygonati 1 ~ 5 part, Rhizoma Polygonati Odorati 1 ~ 5 part, Fructus Phyllanthi 1 ~ 5 part, 1 ~ 3 part, Fructus Jujubae, first meat 1 ~ 5 part, Fructus Lycii 5 ~ 15 parts, Agaricus blazei Murrill 1 ~ 5 part, Semen Hoveniae (Fructus Hoveniae) 1 ~ 5 part, Fructus Mume 0 ~ 4 part, Fructus Mori 0 ~ 5 part, Fructus Crataegi 0 ~ 6 part, Fructus Rubi 0 ~ 4, Fructus Momordicae 1 ~ 5 part, Fructus Alpiniae Oxyphyllae 1 ~ 5 part, Radix Ginseng 1 ~ 5 part, Bulbus Lilii 1 ~ 5 part and Poria 1 ~ 5 part.
Preferably, the parts by weight of each crude drug are: Rhizoma Polygonati 1 ~ 3 part, Rhizoma Polygonati Odorati 1 ~ 3 part, Fructus Phyllanthi 1 ~ 3 part, 1 ~ 3 part, Fructus Jujubae, first meat 1 ~ 5 part, Fructus Lycii 6 ~ 12 parts, Agaricus blazei Murrill 1 ~ 3 part, Semen Hoveniae (Fructus Hoveniae) 1 ~ 3 part, Fructus Mume 1 ~ 3 part, Fructus Mori 1 ~ 3 part, Fructus Crataegi 1 ~ 5 part, Fructus Rubi 1 ~ 3, Fructus Momordicae 1 ~ 3 part, Fructus Alpiniae Oxyphyllae 1 ~ 3 part, Radix Ginseng 1 ~ 3 part, Bulbus Lilii 1 ~ 3 part and Poria 1 ~ 3 part.
Preferably, the parts by weight of each crude drug are: Rhizoma Polygonati 2 parts, Rhizoma Polygonati Odorati 2 parts, Fructus Phyllanthi 2 parts, 1 part, Fructus Jujubae, first meat 1 part, Fructus Lycii 10 parts, Agaricus blazei Murrill 1 part, Semen Hoveniae (Fructus Hoveniae) 2 parts, Fructus Mume 1 part, Fructus Mori 2 parts, Fructus Crataegi 5 parts, Fructus Rubi 1, Fructus Momordicae 1 part, Fructus Alpiniae Oxyphyllae 2 parts, Radix Ginseng 2 parts, Bulbus Lilii 2 parts and Poria 2 parts;
Preferably, the sweeting agent that weight portion is 1 ~ 5 part is also comprised in described component.
Preferably, the sweeting agent that weight portion is 2 parts is also comprised in described component.
Preferably, described sweeting agent is one or more in acesulfame potassium, xylitol, aspartame, sucralose;
A beverage prepared by the Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms, is characterized in that its preparation method comprises the steps:
(1) Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Phyllanthi, Fructus Jujubae, first meat, Fructus Lycii part, Agaricus blazei Murrill, Semen Hoveniae (Fructus Hoveniae), Fructus Mume, Fructus Mori, Fructus Crataegi, Fructus Rubi, Fructus Momordicae, Fructus Alpiniae Oxyphyllae, Radix Ginseng, Bulbus Lilii and Poria is taken respectively by proportioning;
(2) component in step (1) is put into container, add distilled water, the quality adding water is 80 ~ 100 times that take constituent mass summation in step (1), 15 ~ 35 minutes are continued after boiling, pour out extracting solution, the quality adding distilled water again in container is 70 ~ 90 times that take constituent mass summation in step (1), continues 10 ~ 25 minutes, pour out extracting liq after boiling;
(3) merged by the extracting solution poured out for twice in step (2), normal pressure is concentrated into 50 ~ 70 times of the constituent mass taken in step (1);
(4) in the solution through step (3), add sweeting agent by proportioning, stir;
(5) sterilizing.
When taking, every day 1 ~ 2 time, each 300 ~ 350ml.
A granule prepared by the Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms, is characterized in that its preparation method comprises the steps:
(1) Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Phyllanthi, Fructus Jujubae, first meat, Fructus Lycii part, Agaricus blazei Murrill, Semen Hoveniae (Fructus Hoveniae), Fructus Mume, Fructus Mori, Fructus Crataegi, Fructus Rubi, Fructus Momordicae, Fructus Alpiniae Oxyphyllae, Radix Ginseng, Bulbus Lilii and Poria is taken respectively by proportioning;
(2) component in step (1) is put into container, add distilled water, the quality adding water is 80 ~ 100 times that take constituent mass summation in step (1), 15 ~ 35 minutes are continued after boiling, pour out extracting solution, the quality adding distilled water again in container is 70 ~ 90 times that take constituent mass summation in step (1), continues 10 ~ 25 minutes, pour out extracting liq after boiling;
(3) merged by the extracting solution poured out for twice in step (2), normal pressure is concentrated into the thick paste that proportion is 1.115-1.200;
(4) thick paste of step (3) is dry under 70 degrees Celsius;
(5) pulverize, granulate.
When taking, every day 2 ~ 3 times, each 0.2 ~ 0.4g.
A powder prepared by the Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms, is characterized in that its preparation method comprises the steps:
(1) Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Phyllanthi, Fructus Jujubae, first meat, Fructus Lycii part, Agaricus blazei Murrill, Semen Hoveniae (Fructus Hoveniae), Fructus Mume, Fructus Mori, Fructus Crataegi, Fructus Rubi, Fructus Momordicae, Fructus Alpiniae Oxyphyllae, Radix Ginseng, Bulbus Lilii part and Poria is taken respectively by proportioning;
(2) component in step (1) is put into container, add distilled water, the quality adding water is 80 ~ 100 times that take constituent mass summation in step (1), 15 ~ 35 minutes are continued after boiling, pour out extracting solution, the quality adding distilled water again in container is 70 ~ 90 times that take constituent mass summation in step (1), continues 10 ~ 25 minutes, pour out extracting liq after boiling;
(3) merged by the extracting solution poured out for twice in step (2), normal pressure is concentrated into the thick paste that proportion is 1.115-1.200;
(4) liquid of step (3) is dry under 70 degrees Celsius;
(5) pulverize.
When taking, every day 1 ~ 3 time, each 0.2 ~ 0.4g.
A medicated wine prepared by the Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms, is characterized in that its preparation method comprises the steps:
(1) Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Phyllanthi, Fructus Jujubae, first meat, Fructus Lycii part, Agaricus blazei Murrill, Semen Hoveniae (Fructus Hoveniae), Fructus Mume, Fructus Mori, Fructus Crataegi, Fructus Rubi, Fructus Momordicae, Fructus Alpiniae Oxyphyllae, Radix Ginseng, Bulbus Lilii and Poria is taken respectively by proportioning;
(2) component in step (1) is put into container, add the ethanol that concentration is (40-60%), the quality adding ethanol in container is 50-70 times that takes constituent mass summation in step (1), soak 20 days under room temperature, pour out extracting solution, the quality adding ethanol again in container be the 40-60 taking constituent mass summation in step (1) doubly, soak 20 days under room temperature, pour out extracting solution;
(3) merged by the extracting solution poured out for twice in step (2), normal pressure is concentrated into 50 ~ 70 times of the constituent mass taken in step (1);
(4) subpackage
When taking, every day 2 ~ 3 times, each 10 ~ 60ml.
In pharmaceutical composition of the present invention:
Rhizoma Polygonati: sweet, flat, nontoxic, be used as medicine with rhizome, there is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions; Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat such as to be quenched one's thirst the disease, has immunity moderation and control function of tumor, very effective in cure for diabetes.
Rhizoma Polygonati Odorati: sweet in the mouth, property is put down, and return lung, stomach warp, nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, fills blood, and invigorating middle warmer spleen invigorating has blood sugar lowering, anti-oxidative stress.
Fructus Phyllanthi: really: sweet, sour, puckery, cool, returns lung meridian, stomach warp; Root: light is flat; Leaf: pungent is flat.Refreshing and detoxicating, controls sore throat, antibacterial, has the effect improving immunity.
Fructus Jujubae: sweet, temperature, returns spleen, stomach warp; Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
Unit's meat: sweet, temperature, enters the heart, spleen channel; Heart-spleen boosting fills blood, and has good nourishing benefiting action, can be used for the insufficiency of the spleen damage of the heart, insomnia caused by insufficiency of vital energy and blood, forgetful, palpitation with fear, the disease such as dizzy, also can treat weak or mental deterioration after being ill.
Fructus Lycii: sweet in the mouth, property is put down, and returns Liver Channel, kidney channel, lung meridian; Can nourishing the liver, nourishing kidney, lung moistening, caused by liver and kidney deficiency; Cure mainly and have a dizzy spell, visual unclear, soreness of the waist and knees, impotence and seminal emission, cough due to consumptive disease, taking fluids profusely of quenching one's thirst.
Agaricus blazei Murrill: property is put down, sweet in the mouth, GUIXIN, lung, liver, kidney channel; There is brain-strengthening, antiinflammatory, kidney tonifying, blood sugar lowering, improve diabetes, cholesterol reducing, enhancing energy, improve the effect such as arteriosclerosis, anti-angiocardiopathy.
Semen Hoveniae (Fructus Hoveniae): sweet in the mouth, flat, nontoxic, enter the heart, spleen two warp; Quench the thirst relieving restlessness, moistening five ZANG-organs, sharp defecation, goes heat on diaphragm.
Fructus Mume: sour, puckery, flat, return liver, spleen, lung, large intestine channel; Astringe the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris; For chronic cough of deficiency lung; Deficiency-heat excessive thirst; Chronic malaria; Chronic diarrhea; Dysentery; Have blood in stool; Hematuria; Metrorrhagia; The ascariasis of biliary tract is suffered from abdominal pain; Vomiting; Ancylostomiasis.
Fructus Mori: cool sweet, sour, sweet; Blood Yin-nourishing and body fluid promoting quenches the thirst; Nonspecific immunity function can be strengthened.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel; Function cures mainly: appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm.For meat stagnant long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.
Fructus Rubi: sweet acid, flat; Return liver, kidney channel; Invigorating the liver and kidney, urine reducing, supporing yang, controlling nocturnal emission with astringent drugs, improving eyesight, controls sexual impotence, and seminal emission, frequency of micturition, incontinence of urine, asthenia, order is dark.
Fructus Momordicae: cool in nature, sweet in the mouth, returns lung, large intestine channel; Function cures mainly: kidney, life prolonging are supported in the kidney invigorating, can prevent and treat acute renal failure, clearing heat and moistening lung, cough-relieving, sore-throat relieving, laxation relieving constipation.For lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.
Fructus Alpiniae Oxyphyllae: acrid in the mouth; Warm in nature; GUIXIN, spleen; Kidney channel; Effect: the kidney warming controlling nocturnal emission with astringent drugs reducing urination, saliva is taken the photograph in warming the spleen appetizing.
Radix Ginseng: sweet in the mouth, micro-hardship is warm in nature, flat; Return spleen, lung meridian, heart channel; Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.
Bulbus Lilii: sweet; Micro-hardship; Be slightly cold; GUIXIN; Lung meridian; Function cures mainly: nourishing YIN and moistening the lung; Clearing away heart-fire for tranquillization, main deficiency of YIN chronic cough; Sputum mixed with blood; The calentura later stage; Waste heat is clear, or the unsuccessful caused fidgets due to deficiency palpitation with fear of feelings will, insomnia and dreamful sleep, absentminded; Carbuncle; Eczema.
Poria: sweet, light is flat; GUIXIN warp, lung meridian, spleen channel, kidney channel; Mind tranquilizing and the heart calming, relieves internal heat anticancer.Mild in medicine property and, dampness removing and do not hinder healthy energy.Dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis can be controlled, have loose bowels, pass out semen, stranguria with turbid discharge, palpitation with fear, the disease such as forgetful.Contained pachymic acid has the effect of enhancing immunity, antitumor and calmness, blood sugar lowering etc.Can be relaxed gastrointestinal smooth muscle, the effects such as gastric acid secretion inhibiting, prevents hepatic necrosis, antibacterial.
In drug component of the present invention, Rhizoma Polygonati has life lengthening, luxuriant growth intensive culture face, immunity moderation and control function of tumor, in addition, polygonatum polysaccharide can reduce Blood-serum of Diet-induced Atherosclerotic Rabbit interleukin-6 (IL-6) and c reactive protein (CRP), stop developing of blood vessel endothelium inflammatory reaction, there is antiatherogenic effect, the impact of polygonatum polysaccharide on blood glucose in diabetic rats level is studied, and result of study shows, and polygonatum polysaccharide significantly can reduce the blood glucose in diabetic rats level of alloxan induction, and the hypoglycemic effect of high dose group is remarkable, Rhizoma Polygonati Odorati can strengthen immunologic function, cyclophosphamide can be improved and cause immunodeficiency models mouse thymus, spleen weight, macrophage phagocytic percentage rate, phagocytic index, promote hemolysin, haemolysis speckle is formed, improve lymhocyte transformation rate, it is active that fragrant solomonseal rhizome polyoses can also improve mouse aging serum superoxide dismutases, strengthen the Scavenging activity to free radical, anti-lipid peroxidation, reduce MDA content, it has certain regulating action to the immunologic function of subacute aging mice simultaneously, immune imbalance state can be improved, strengthen cell and humoral immune function, thus slow down aging, in addition, fragrant solomonseal rhizome polyoses has blood sugar lowering, anti-oxidative stress, significant protective effect is had to the B cell damage of diabetes rat caused by alloxan, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Alpiniae Oxyphyllae, Radix Ginseng, Bulbus Lilii the kidney invigorating invigorating the spleen to benefit the lung health preserving with drugs the moon is monarch drug.Poria, Fructus Rubi, Fructus Mori, Agaricus blazei Murrill, Fructus Lycii and Fructus Phyllanthi assist monarch drug tonifying kidney and nourishing yin, and raising immunity of organisms is ministerial drug, Fructus Momordicae, Semen Hoveniae (Fructus Hoveniae), Fructus Mume and first meat, can stomach invigorating, nourish heart, spleen invigorating is adjuvant drug, and Fructus Crataegi and Fructus Jujubae coordinating the actions of various ingredients in a prescription are for making medicine.
Technique effect of the present invention is as follows:
The present invention is for strengthening the Chinese herbal medicine beverage of middle-aged and elderly people immunity of organisms, and for the physical weakness of middle-aged and elderly people one, adopting with kidney is this, improve immunity, hypoglycemic formula, accurately dialectical, select medicine reasonable, mild in medicine property and, harmless gastric qi, is applicable to the auxiliary treatment of chronic disease and the adjustment of body function, Be very effective, applicable middle-aged and elderly people is drunk, and substantially increases the quality of life of middle-aged and elderly people after taking; Adopt the food and medicament dual-purpose food of national regulation in the present invention, have no side effect; Adopt the natural and natural plants with medical value as Fructus Mume, Fructus Crataegi, first meat, Fructus Mori, Fructus Momordicae, Fructus Lycii in the present invention, traditional sucrose, citric acid, sodium citrate is replaced with its intrinsic taste, carry out beverage seasoning, taste good, the existing merit except disease conditioning, the fraud of tasteless suffering pharynx again, is easy to be accepted by extensive patients; The present invention adopts one or more the tune sweet tastes in acesulfame potassium, xylitol, aspartame, sucralose, not containing sucrose, is applicable to middle-aged and elderly people, is especially applicable to diabetic to take.
Chinese herbal medicine beverage of the present invention is described in detail below in conjunction with specific embodiment:
Table 1 embodiment 1 ~ 4
Preparation method is as follows:
(1) Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Phyllanthi, Fructus Jujubae, first meat, Fructus Lycii part, Agaricus blazei Murrill, Semen Hoveniae (Fructus Hoveniae), Fructus Mume, Fructus Mori, Fructus Crataegi, Fructus Rubi, Fructus Momordicae, Fructus Alpiniae Oxyphyllae, Radix Ginseng, Bulbus Lilii and Poria is taken by the proportioning of embodiment in table 11 ~ 4 respectively, put into four containers, be labeled as container 1, container 2, container 3, container 4;
Embodiment 1: add distilled water in container 1, the quality adding water is 80 times that take constituent mass summation in step (1), 15 minutes are continued after boiling, pour out extracting solution, the quality adding distilled water again in container is 70 times that take constituent mass summation in step (1), continue 20 minutes after boiling, pour out extracting liq; The extracting solution poured out above-mentioned twice merges, and normal pressure is concentrated into step (1) normal pressure and is concentrated into the thick paste that proportion is 1.116;
Dry, pulverize under 70 degrees Celsius, add the ethanol that appropriate volume concentration is 70 ~ 80%, mix homogeneously, make the raw material components after pulverizing reach the state of " gently hold agglomerating, namely that touches falls apart ", granulate.
When taking, every day 2 ~ 3 times, each 0.2 ~ 0.4g.
Embodiment 2: add distilled water in container 2, the quality adding water is 90 times that take constituent mass summation in step (1), 20 minutes are continued after boiling, pour out extracting solution, the quality adding distilled water again in container is 76 times that take constituent mass summation in step (1), continue 25 minutes after boiling, pour out extracting liq; The extracting solution poured out above-mentioned twice merges, and normal pressure is concentrated into 65 times of the constituent mass taken in step (1); In the solution after concentrated, add 2g xylitol by proportioning, stir, sterilizing.
When taking, every day 1 ~ 2 time, each 300 ~ 350ml.
Embodiment 3: add distilled water in container 3, the quality adding water is 95 times that take constituent mass summation in step (1), 30 minutes are continued after boiling, pour out extracting solution, the quality adding distilled water again in container is 90 times that take constituent mass summation in step (1), continue 10 minutes after boiling, pour out extracting liq; The extracting solution poured out above-mentioned twice merges, and normal pressure is concentrated into step (1) normal pressure and is concentrated into the thick paste that proportion is 1.1158; Dry, pulverize under 70 degrees Celsius.
When taking, every day 1 ~ 3 time, each 0.2 ~ 0.4g.
Embodiment 4: add ethanol in container 4, to add volumetric concentration be concentration is the ethanol of 40-60%, the quality adding ethanol in container be the 50-70 taking constituent mass summation in step (1) doubly, soak 20 days under room temperature, pour out extracting solution, the quality adding ethanol again in container is 50 times that take constituent mass summation in step (1), soaks 20 days, pour out extracting solution under room temperature; Merged by the extracting solution poured out for twice in step (2), normal pressure is concentrated into 60 times of the constituent mass taken in step (1); Subpackage.
When taking, every day 2 ~ 3 times, each 10 ~ 60ml.
Enumerate model case as follows:
Case 1:
Lee, man, 45 years old, hypoimmunity, poor appetite, caught a cold often, takes the Chinese medicine composition of embodiment 1, and after taking 30 days, all diseases disappear entirely.
Case 2:
Wang, man, 53 years old, brothers' fear of cold, susceptible to lose temper due to restlessness, frequent micturition, constipation, took the Chinese medicine composition of embodiment 3, and after taking 18 days, symptom alleviates, and continue to take 15 days, all diseases disappear entirely.
Case 3:
Model so-and-so, female, 67 years old, lethargy, fatigue and weak, appetite reduce, excessive phlegm, often numbness of hands and feet, take the Chinese medicine composition of embodiment 4, and within 23 days, symptom is obviously improved, and has consolidated again one month afterwards, rehabilitation, has not recurred so far.
Case 4:
Determine the experimenter of this test: 1. how sick dizziness and tinnitus, insomnia and dreamful sleep, dyspepsia, sore waist and aching in the waist and the back, palpitation and short breath, body void is; 2. chronic cough excessive phlegm, brothers' fear of cold, susceptible to lose temper due to restlessness, frequent micturition, constipation; 3. numbness of hands and feet, the puckery asthma of lung, easily infected.For in the immunocompromised person coming to go to a doctor, random selecting 80, minimum 38 years old of age, maximum 77 years old; Male patient 34 example, female patient 46 example; All patients take the Chinese medicine composition beverage of embodiment 2, take 1 ~ 2 every day, a 300ml ~ 350ml, treat 15 ~ 40 days.
Criterion of therapeutical effect after treatment of the present invention is determined as follows:
(1) clinical recovery: clinical symptoms, sign disappear, functional activity recovers normal, checks that indices recovers.(2) effective: symptom obviously alleviates.(3) effective: symptom alleviates slightly.(4) invalid: clinical symptoms, sign are without change.
Therapeutic effect is as shown in table 2.
Table 2 therapeutic effect
Cure rate Obvious effective rate Effective percentage Inefficiency
13% 47% 36% 4%
As can be seen from Table 2, the patient that beverage of the present invention is low to immunity of organisms has good curative effect.
Experimental example 1
Get ICR mice 36, male and female half and half, weight is 20.0 ± 2.0g, is divided into four groups at random by body weight, often organizes 6, is respectively experimental group 1, experimental group 2, experimental group 3 and matched group 4-1, matched group 4-2, matched group 4-3, records the weight of every mice; Matched group 4-1, matched group 4-2, matched group 4-3 every day, fill with and be respectively every 0.2ml/ days, 0.4ml/ days, 0.6ml/ days to amount, continuous gavage recorded the weight of mice again after one week to mouse stomach normal saline; Successive administration records the weight of mice to experimental group 1 ~ 3 again after one week to the beverage of mouse stomach embodiment 2 every day, fills with and is often only respectively 0.2ml/ days, 0.4ml/ days, 0.6ml/ days to amount; The mice of experimental group and matched group is after last administration 30min, respectively at the weight of mouse tail bundle one 2g, mice is put into respectively glass jar to swim, start timing, then note observe, when mice submerged again risk one's life struggle expose nose 3 ~ 4 times, and struggle be difficult to the person of emerging be muscle power exhaust, at once timing terminates, this interval swimming time for mice that clocks.In experimentation, the tank carrying out swimming test is enough large, and water is put enough dark, and the tail of mice can not touch the bottom of glass jar, in addition, if mice does not initiatively move about, just fiddles with Glass rod, impels it to swim.
Before and after administration, the change of each experimental group and each control group mice body weight is in table 3.
Table 3 tests front and back experimental group and control group mice body weight change (g, x ± s)
Group Before administration After administration Increment
Matched group 4-1 21.18±0.70 26.02±0.61 4.84±0.98
Matched group 4-2 21.17±0.65 26.06±0.86 4.89±0.51
Matched group 4-3 20.94±0.88 25.86±1.11 4.92±0.10
Experimental group 1 21.58±0.54 27.98±0.68 6.40±1.14
Experimental group 2 20.58±0.87 29.18±0.68 8.60±1.20
Experimental group 3 20.22±0.76 30.82±0.55 10.60±0.69
As can be seen from Table 3, matched group 4-1,4-2,4-3 before administration after, body weight no significant difference, in experimental group 1 ~ 3, after administration, the weight of mice all has increase than weight before administration, along with the increase of day gavage amount, it is more obvious that Mice Body weight increases, namely after administration, the body weight increment of the body weight increment > experimental group 1 of the body weight increment > experimental group 2 of experimental group 3, illustrates that medicine of the present invention can the appetite of enhancing body, promotes alimentation.
The swimming time of each experimental group and each control group mice is in table 4.
Table 4 respectively group mice swimming time compares (x ± s)
Group Swimming time (min)
Matched group 4-1 7.44±0.91
Matched group 4-2 6.87±0.88
Matched group 4-3 7.25±0.42
Experimental group 1 8.78±1.00
Experimental group 2 9.86±0.35
Experimental group 3 28.56±0.69
As can be seen from Table 4, the each mice swimming time of matched group is more or less the same, experimental group 1 ~ 3 all extends than the swimming time of each matched group, wherein, the time expand of the time expand > experimental group 1 of the time expand > experimental group 2 of experimental group 3, after beverage of the present invention is taken in explanation, can effectively improve the mice burden swimming time, add the anti-fatigue ability of mice.
Experimental example 2
Get the rear mice of experimental example 1 went swimming experiment, make it have a rest 2 days to regain one's strength.Give the Chinese medicine composition 0.2mL of every mouse stomach experimental example 4 of experimental group 1 ~ 3 respectively, 0.3mL, 0.4mL, give matched group 4-1 respectively, 4-2, every mouse stomach 0.2mL of 4-3, 0.3mL, the normal saline of 0.4mL, the mice of each experimental group and each matched group fills with rear 30min, respectively mice is put into the 200mL wide mouthed bottle filling 15g sodica calx, only put 1 mice for every bottle, tight by vaseline applicating bottle lid, make it air tight, timing immediately, when mouse breathing stops, the record time now, the time that the interval of twice timing is mice death because of anoxia, i.e. the survival time under hypoxic condition.In experimentation, sodica calx not directly drops in wide mouthed bottle, but wraps up with gauze, mice can not be allowed directly to contact, otherwise mice eats sodica calx by mistake, will directly affect the accuracy of experiment, or mouse eye is burnt by sodica calx and is caused severe pain, manic uneasiness, also affects the accuracy of experiment.
The survival time under hypoxic condition of each experimental group and each control group mice is in table 5.
Table 5 respectively group mice hypoxia endurance time compares (x ± s)
Group The survival time under hypoxic condition (min)
Matched group 4-1 19.92±2.12
Matched group 4-2 18.66±2.03
Matched group 4-3 18.85±1.77
Experimental group 1 24.52±2.32
Experimental group 2 25.38±2.21
Experimental group 3 28.66±1.28
As can be seen from Table 5, the anoxia in mice time-to-live of matched group 4-1,4-2,4-3 is more or less the same, after taking the beverage of experimental example 3, effectively improve the hypoxia-bearing capability of mice, the survival time under hypoxic condition of the survival time under hypoxic condition > experimental group 1 of the survival time under hypoxic condition > experimental group 2 of experimental group 3.Mice receives the infringement of anoxia under closed environment, mainly be reflected in heart and brain, the raising of oxygen-resistant ability, mainly because body cell improves the adaptability of anoxia enduring environment, body deposit and utilize the ability of oxygen to improve, operational capability is corresponding raising also, and immunity of organisms also can correspondingly improve.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.

Claims (10)

1. strengthen a Chinese medicine composition for middle-aged and elderly people immunity of organisms, it is characterized in that it comprises the raw material components of following parts by weight: Rhizoma Polygonati 1 ~ 5 part, Rhizoma Polygonati Odorati 1 ~ 5 part, Fructus Phyllanthi 1 ~ 5 part, 1 ~ 3 part, Fructus Jujubae, first meat 1 ~ 5 part, Fructus Lycii 5 ~ 15 parts, Agaricus blazei Murrill 1 ~ 5 part, Semen Hoveniae (Fructus Hoveniae) 1 ~ 5 part, Fructus Mume 0 ~ 4 part, Fructus Mori 0 ~ 5 part, Fructus Crataegi 0 ~ 6 part, Fructus Rubi 0 ~ 4, Fructus Momordicae 1 ~ 5 part, Fructus Alpiniae Oxyphyllae 1 ~ 5 part, Radix Ginseng 1 ~ 5 part, Bulbus Lilii 1 ~ 5 part and Poria 1 ~ 5 part.
2. a kind of Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms according to claim 1, is characterized in that the parts by weight of each crude drug are: Rhizoma Polygonati 1 ~ 3 part, Rhizoma Polygonati Odorati 1 ~ 3 part, Fructus Phyllanthi 1 ~ 3 part, 1 ~ 3 part, Fructus Jujubae, first meat 1 ~ 5 part, Fructus Lycii 6 ~ 12 parts, Agaricus blazei Murrill 1 ~ 3 part, Semen Hoveniae (Fructus Hoveniae) 1 ~ 3 part, Fructus Mume 1 ~ 3 part, Fructus Mori 1 ~ 3 part, Fructus Crataegi 1 ~ 5 part, Fructus Rubi 1 ~ 3, Fructus Momordicae 1 ~ 3 part, Fructus Alpiniae Oxyphyllae 1 ~ 3 part, Radix Ginseng 1 ~ 3 part, Bulbus Lilii 1 ~ 3 part and Poria 1 ~ 3 part.
3. a kind of Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms according to claim 1 and 2, is characterized in that the parts by weight of each crude drug are: Rhizoma Polygonati 2 parts, Rhizoma Polygonati Odorati 2 parts, Fructus Phyllanthi 2 parts, 1 part, Fructus Jujubae, first meat 1 part, Fructus Lycii 10 parts, Agaricus blazei Murrill 1 part, Semen Hoveniae (Fructus Hoveniae) 2 parts, Fructus Mume 1 part, Fructus Mori 2 parts, Fructus Crataegi 5 parts, Fructus Rubi 1, Fructus Momordicae 1 part, Fructus Alpiniae Oxyphyllae 2 parts, Radix Ginseng 2 parts, Bulbus Lilii 2 parts and Poria 2 parts.
4., according to the arbitrary described a kind of Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms of claim 1 or 2, it is characterized in that in described component, also comprising the sweeting agent that weight portion is 1 ~ 5 part.
5. a kind of Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms according to claim 3, is characterized in that also comprising the sweeting agent that weight portion is 2 parts in described component.
6., according to the arbitrary described a kind of Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms of claim 4 or 5, it is characterized in that described sweeting agent is one or more in acesulfame potassium, xylitol, aspartame, sucralose.
7. the beverage using a kind of Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms described in claim 1 to prepare, is characterized in that its preparation method comprises the steps:
(1) Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Phyllanthi, Fructus Jujubae, first meat, Fructus Lycii part, Agaricus blazei Murrill, Semen Hoveniae (Fructus Hoveniae), Fructus Mume, Fructus Mori, Fructus Crataegi, Fructus Rubi, Fructus Momordicae, Fructus Alpiniae Oxyphyllae, Radix Ginseng, Bulbus Lilii and Poria is taken respectively by proportioning;
(2) component in step (1) is put into container, add distilled water, the quality adding water is 80 ~ 100 times that take constituent mass summation in step (1), 15 ~ 35 minutes are continued after boiling, pour out extracting solution, the quality adding distilled water again in container is 70 ~ 90 times that take constituent mass summation in step (1), continues 10 ~ 25 minutes, pour out extracting liq after boiling;
(3) merged by the extracting solution poured out for twice in step (2), normal pressure is concentrated into 50 ~ 70 times of the constituent mass taken in step (1);
(4) add sweeting agent by the solution of step (3) by proportioning, stir;
(5) sterilizing;
(6) subpackage.
8. the granule using a kind of Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms described in claim 1 to prepare, is characterized in that its preparation method comprises the steps:
(1) Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Phyllanthi, Fructus Jujubae, first meat, Fructus Lycii part, Agaricus blazei Murrill, Semen Hoveniae (Fructus Hoveniae), Fructus Mume, Fructus Mori, Fructus Crataegi, Fructus Rubi, Fructus Momordicae, Fructus Alpiniae Oxyphyllae, Radix Ginseng, Bulbus Lilii and Poria is taken respectively by proportioning;
(2) component in step (1) is put into container, add distilled water, the quality adding water is 80 ~ 100 times that take constituent mass summation in step (1), 15 ~ 35 minutes are continued after boiling, pour out extracting solution, the quality adding distilled water again in container is 70 ~ 90 times that take constituent mass summation in step (1), continues 10 ~ 25 minutes, pour out extracting liq after boiling;
(3) merged by the extracting solution poured out for twice in step (2), normal pressure is concentrated into the thick paste that proportion is 1.115-1.200;
(4) thick paste of step (3) is dry under 70 degrees Celsius;
(5) pulverize, granulate.
9. the powder using a kind of Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms described in claim 1 to prepare, is characterized in that its preparation method comprises the steps:
(1) Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Phyllanthi, Fructus Jujubae, first meat, Fructus Lycii part, Agaricus blazei Murrill, Semen Hoveniae (Fructus Hoveniae), Fructus Mume, Fructus Mori, Fructus Crataegi, Fructus Rubi, Fructus Momordicae, Fructus Alpiniae Oxyphyllae, Radix Ginseng, Bulbus Lilii and Poria is taken respectively by proportioning;
(2) component in step (1) is put into container, add distilled water, the quality adding water is 80 ~ 100 times that take constituent mass summation in step (1), 15 ~ 35 minutes are continued after boiling, pour out extracting solution, the quality adding distilled water again in container is 70 ~ 90 times that take constituent mass summation in step (1), continues 10 ~ 25 minutes, pour out extracting liq after boiling;
(3) merged by the extracting solution poured out for twice in step (2), normal pressure is concentrated into the thick paste that proportion is 1.115-1.200;
(4) liquid of step (3) is dry under 70 degrees Celsius;
(5) pulverize.
10. the medicated wine using a kind of Chinese medicine composition strengthening middle-aged and elderly people immunity of organisms described in claim 1 to prepare, is characterized in that its preparation method comprises the steps:
(1) Rhizoma Polygonati, Rhizoma Polygonati Odorati, Fructus Phyllanthi, Fructus Jujubae, first meat, Fructus Lycii part, Agaricus blazei Murrill, Semen Hoveniae (Fructus Hoveniae), Fructus Mume, Fructus Mori, Fructus Crataegi, Fructus Rubi, Fructus Momordicae, Fructus Alpiniae Oxyphyllae, Radix Ginseng, Bulbus Lilii and Poria is taken respectively by proportioning;
(2) component in step (1) is put into container, add the ethanol that volumetric concentration is 40-60%, the quality adding ethanol in container is 50-70 times that takes constituent mass summation in step (1), soak 20 days under room temperature, pour out extracting solution, the quality adding ethanol again in container be the 40-60 taking constituent mass summation in step (1) doubly, soak 20 days under room temperature, pour out extracting solution;
(3) merged by the extracting solution poured out for twice in step (2), normal pressure is concentrated into 50 ~ 70 times of the constituent mass taken in step (1);
(4) subpackage.
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CN105535552A (en) * 2016-03-04 2016-05-04 上海交通大学医学院附属第九人民医院 Traditional Chinese medicine oral liquid for improving immunity of human bodies and preparation method of traditional Chinese medicine oral liquid
CN107397926A (en) * 2017-07-04 2017-11-28 唐瑟悦 A kind of ganoderma lucidum liver-smoothing, qi-regulating increases first wine and preparation method thereof
CN108125003A (en) * 2017-11-21 2018-06-08 河北林益堂药业有限公司 One seed ginseng essence the ancient philosophers's tea
CN109077321A (en) * 2018-10-29 2018-12-25 吕彦辉 A kind of composition and preparation method thereof with strengthen immunity and antioxidation
CN110917291A (en) * 2019-12-12 2020-03-27 江苏康缘药业股份有限公司 Composition with function of improving immunity and preparation method and application thereof
CN111000938A (en) * 2020-01-17 2020-04-14 杨波 Sanqing powder for removing lipotoxin and sugar poison and preventing and treating diabetic complications
CN111110792A (en) * 2020-01-17 2020-05-08 杨波 Rhizoma polygonati and ginseng tea for controlling sugar, regulating lipid, reducing viscosity, preventing and treating diabetes and complications thereof
CN112674338A (en) * 2020-12-23 2021-04-20 北京博瑞世安科技有限公司 Composition with anti-fatigue effect and preparation method and application thereof
CN113616732A (en) * 2021-08-31 2021-11-09 大姚华盛饮料食品有限责任公司 Formula and preparation method of ginseng-olive tablet
CN113812617A (en) * 2021-09-28 2021-12-21 厦门市燕之屋丝浓食品有限公司 Instant cubilose product suitable for middle-aged and old people and preparation method thereof

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CN105535552A (en) * 2016-03-04 2016-05-04 上海交通大学医学院附属第九人民医院 Traditional Chinese medicine oral liquid for improving immunity of human bodies and preparation method of traditional Chinese medicine oral liquid
CN107397926A (en) * 2017-07-04 2017-11-28 唐瑟悦 A kind of ganoderma lucidum liver-smoothing, qi-regulating increases first wine and preparation method thereof
CN108125003A (en) * 2017-11-21 2018-06-08 河北林益堂药业有限公司 One seed ginseng essence the ancient philosophers's tea
CN109077321A (en) * 2018-10-29 2018-12-25 吕彦辉 A kind of composition and preparation method thereof with strengthen immunity and antioxidation
CN110917291A (en) * 2019-12-12 2020-03-27 江苏康缘药业股份有限公司 Composition with function of improving immunity and preparation method and application thereof
CN111000938A (en) * 2020-01-17 2020-04-14 杨波 Sanqing powder for removing lipotoxin and sugar poison and preventing and treating diabetic complications
CN111110792A (en) * 2020-01-17 2020-05-08 杨波 Rhizoma polygonati and ginseng tea for controlling sugar, regulating lipid, reducing viscosity, preventing and treating diabetes and complications thereof
CN112674338A (en) * 2020-12-23 2021-04-20 北京博瑞世安科技有限公司 Composition with anti-fatigue effect and preparation method and application thereof
CN113616732A (en) * 2021-08-31 2021-11-09 大姚华盛饮料食品有限责任公司 Formula and preparation method of ginseng-olive tablet
CN113812617A (en) * 2021-09-28 2021-12-21 厦门市燕之屋丝浓食品有限公司 Instant cubilose product suitable for middle-aged and old people and preparation method thereof
CN113812617B (en) * 2021-09-28 2024-02-09 厦门市燕之屋丝浓食品有限公司 Instant edible bird's nest product suitable for middle-aged and elderly people and preparation method thereof

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