CN106177485A - The medicated tea of a kind of Yishen Jianpi treatment hemoglobinuria and preparation processing method - Google Patents

The medicated tea of a kind of Yishen Jianpi treatment hemoglobinuria and preparation processing method Download PDF

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CN106177485A
CN106177485A CN201610234290.5A CN201610234290A CN106177485A CN 106177485 A CN106177485 A CN 106177485A CN 201610234290 A CN201610234290 A CN 201610234290A CN 106177485 A CN106177485 A CN 106177485A
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parts
radix
herba
vitis viniferae
herba dendrobii
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温从字
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Zhejiang Yu Chen Pharmaceutical Co Ltd
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Zhejiang Yu Chen Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23FCOFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00Tea; Tea substitutes; Preparations thereof
    • A23F3/34Tea substitutes, e.g. matè; Extracts or infusions thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/60Fish, e.g. seahorses; Fish eggs
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487Psoralea
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/64Orobanchaceae (Broom-rape family)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/69Polygalaceae (Milkwort family)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8984Dendrobium
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/37Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses the medicated tea of a kind of Yishen Jianpi treatment hemoglobinuria of the present invention, be made up of the raw material of following weight portion: Radix Ginseng 1 10 parts, the Radix Astragali 5 15 parts, Radix Codonopsis 39 parts, Cortex et Radix Polygalae 5 12 parts, the Rhizoma Atractylodis Macrocephalae 39 parts, Radix Angelicae Sinensis 39 parts, 5 12 parts of Colla Corii Asini, 5 10 parts of Poria, Herba Agrimoniae 10 30 parts, 5 10 parts of Radix Rehmanniae Preparata, Herba Cirsii 10 16 parts, 5 15 parts of Radix Glycyrrhizae, 6 15 parts of Fructus Jujubae, Fructus Psoraleae 5 10 parts, Herba Cistanches 5 10 parts.The invention have the advantage that inventive formulation can treat little hematuria, asthenia of both the spleen and kidney, malaise, dizziness, have palpitation, breathe hard, the abdomen back of the body is ached, anorexia, middle gas do not save, and improves body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.

Description

The medicated tea of a kind of Yishen Jianpi treatment hemoglobinuria and preparation processing method
Technical field
The present invention relates to the medicated tea of a kind of Yishen Jianpi treatment hemoglobinuria, in particular, relate to a kind of benefit The herb tea formula of kidney and strengthening spleen treatment hemoglobinuria and preparation method thereof technical field.
Background technology
Urine be contained within free hemoglobin and without erythrocyte, or the most a little erythrocyte and containing a large amount of free hemoglobins Phenomenon.Reflect Ink vessel transfusing to have beyond normal haemolysis.The free hemoglobin that can not predict in urine under normal circumstances.When greatly Amount erythrocyte when Ink vessel transfusing dissolved destruction, plasma-free hemoglobin showed increased, exceed hoptoglobin binding ability And then there is hemoglobinuria in the heavy absorbability of near-end renal tubules,convoluted.Hemoglobinuria show as asthenia of both the spleen and kidney, malaise, Dizzy, have palpitation, breathe hard, the abdomen back of the body is ached, rapid breathing, weak, headache, Nausea and vomiting, suffer from abdominal pain, the symptom such as diarrhoea;Can be by benefit Kidney and strengthening spleen treatment hemoglobinuria.
The most traditional beverage, only focuses on mouthfeel, is of low nutritive value, do not have Yishen Jianpi treatment hemoglobinuria, Improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, drop three-hypers, prevent and treat diabetes and anti-cancer, the aspect such as anticancer Function, it is impossible to releasing the sufferings of client, and traditional herbal tea is by Traditional medicine infusion, flavour of a drug weight mouthfeel is poor, it is impossible to preserve for a long time.Mesh Not yet occur a kind of in good taste on front market, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen the drink of body immunity simultaneously Material.
Summary of the invention
The present invention is directed to the deficiency of existing product, and provide a kind of fresh juice beverage to regulate the effect of human physiological functions, This beverage have be easily absorbed by the human body, medicinal function is notable, delicious flavour, good mouthfeel, improve self and increase the wriggling of the intestines and stomach, Cure the disease the medicated tea of a kind of Yishen Jianpi treatment hemoglobinuria simultaneously strengthening the advantage such as body immunity.
The medicated tea of a kind of Yishen Jianpi treatment hemoglobinuria, is made up of the raw material of following weight portion: Radix Ginseng 1-10 part, Radix Astragali 5-15 part, Radix Codonopsis 3-9 part, Cortex et Radix Polygalae 5-12 part, Rhizoma Atractylodis Macrocephalae 3-9 part, Radix Angelicae Sinensis 3-9 part, Colla Corii Asini 5-12 part, Poria 5-10 part, celestial being Crane grass 10-30 part, Radix Rehmanniae Preparata 5-10 part, Herba Cirsii 10-16 part, Radix Glycyrrhizae 5-15 part, Fructus Jujubae 6-15 part, Fructus Psoraleae 5-10 part, Herba Cistanches 5-10 part, Air Bladder pseudosciaenae seu Acipenser 5-10 part, new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae 10-20 part, Mel, water are appropriate.
The preparation processing method of the medicated tea of described a kind of Yishen Jianpi treatment hemoglobinuria, comprises the following steps;
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby;
B, fresh for the Herba Dendrobii cleaned up bar is put into microwave oven, keep temperature 50-60 DEG C, carry out heating 10 minutes, then take Go out to put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time The Chinese liquor of 52-60 DEG C, time 10-15min, the rotating speed of juice extractor is 20~30r/s;After standing 10 minutes, add the fresh bar of Herba Dendrobii The distilled water of weight 2-3 times, for the second time juice extractor time 10-15min, juice extractor rotating speed is 80~100r/s, stands 10min; After carry out third time squeeze the juice, add Herba Dendrobii fresh bar weight 3-5 times distilled water, time 20-30min, juice extractor rotating speed be 100~ 150r/s, separates fresh for Herba Dendrobii bar juice with fiber filter, makes the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, cell damage Rate reaches more than 80%, obtains new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber;The warm water that new fresh grape is put into 50-60 DEG C again cleans dry After Jing, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated stand-by;
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 100-150 in tank Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby;
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 5-10 times of weight, stirring is smashed to 100 mesh, at 30-35 Seal at a temperature of DEG C and preserve 24h, sterilizing, filter, put into unglazed hermetically sealed can, obtain Matrix Solution standby;After extracting Matrix Solution It is the cellulase of 0.5-0.7% that Pericarpium Vitis viniferae and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10, Keep 35 DEG C, water soluble dietary fiber can be extracted further after 24h enzymolysis, water soluble dietary fiber is added Matrix Solution Obtain Matrix Solution II;
E, take mix homogeneously after Radix Ginseng, Radix Codonopsis and Radix Angelicae Sinensis cleaning and sterilizing, respectively with 6 times of weight 85% mol ratio ethanol extractions 2 times, Each 2 hours, merge 2 Radix Ginsengs, Radix Codonopsis and the ethanol extract of Radix Angelicae Sinensis, receive alcohol and be evaporated to relative density at 40 DEG C and be 1.15-1.35, the extract preparing Radix Ginseng, Radix Codonopsis and Radix Angelicae Sinensis is standby;
Fructus Psoraleae, Herba Cistanches, the Radix Astragali, Cortex et Radix Polygalae mix and blend are put into super micron mill, carries out micronizing and obtain 300-400 mesh Ultra micro mixing fine powders;
Taking the Rhizoma Atractylodis Macrocephalae, Colla Corii Asini, Poria, Herba Agrimoniae, Radix Rehmanniae Preparata, Herba Cirsii, Radix Glycyrrhizae, Fructus Jujubae, Air Bladder pseudosciaenae seu Acipenser, mix homogeneously adds 30-60 DEG C of warm water leaching After steeping 10 minutes, put into reach in freezer ,-10~-20 DEG C freezing 10-20 minute, form freezing medicine block, by freezing medicine block with surpass Microring array fine powder boiling is extracted 3 times, adds 1-2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 10-20 and divides Clock;Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes;Third time adds 6-10 times amount water, temperature Keep 120-150 DEG C, carry out infusion 30 minutes, filter, be concentrated into the 1/2 of original volume, add carrying of Radix Ginseng, Radix Codonopsis and Radix Angelicae Sinensis Take thing, obtain Matrix Solution III standby;
F, take Matrix Solution I through instantaneous high-temperature 110-130 DEG C, 1-2 minute, put into material-compound tank;Take Matrix Solution II through mesh Number be 100 mesh fine filter filter after put into material-compound tank;Take Matrix Solution III again to put into after the fine filter filter that mesh number is 60 mesh In material-compound tank;
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae;
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, seal through bottle capper and load in vial, Packaged vial puts into temperature 100~120 DEG C, 1.5MP, sterilization in 15~21 minutes steam ovens, packaging, vanning.
Further: step B) in, after new fresh grape cleans up, put into reach in freezer ,-10~-20 DEG C freezing 5-10 minute, Make Fructus Vitis viniferae freeze, after taking out nature defrosting, then carry out Fructus Vitis viniferae meat and Pericarpium Vitis viniferae detached job.
Further: step H) described in material-compound tank endobasal-body solution I, Matrix Solution II, Matrix Solution III, Oleum Vitis viniferae Weight proportion be 10:0.2~0.8:5~10:0.5.
The Radix Astragali, returns lung, spleen, liver, kidney channel.Enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and Wide antibacterial action.
Radix Ginseng, sweet in the mouth, micro-hardship, warm in nature, flat.Return spleen, lung meridian, heart channel.QI invigorating, Gu de-, promote the production of body fluid, calm the nerves, Fructus Alpiniae Oxyphyllae.For gas Short dyspnea with rapid and short breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and the shock caused after losing blood, collapse.Big benefit Vigour, promotes the production of body fluid Gu de-, calms the nerves.
Radix Codonopsis, sweet, flat.Invigorating the spleen and replenishing QI, stomach function regulating promotes the production of body fluid, expelling phlegm for arresting cough, for weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, Lack of appetite, thirsty.
Cortex et Radix Polygalae, Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, detumescence.The insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, Expectoration is not well.
The Rhizoma Atractylodis Macrocephalae, bitter in the mouth, sweet, warm in nature;Return spleen, stomach warp;Fragrance matter is soft, can rise and can drop, keep and do not walk to have invigorating the spleen and benefiting QI, Dampness diuretic, strengthening superficial resistance to stop perspiration.
Radix Angelicae Sinensis, sweet, pungent, warm, return liver, the heart, spleen channel, enrich blood;Invigorate blood circulation;Menstruction regulating and pain relieving;Moisturize laxation.
Colla Corii Asini, YIN nourishing of enriching blood, moisturize, hemostasis.For blood deficiency and yellow complexion, dizziness cardiopalmus, dysphoria and insomnia, xeropulmonary cough.
Poria, sweet in the mouth, light, property is put down, GUIXIN, lung, spleen, kidney channel, promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.
Herba Agrimoniae is bitter, cool.Return stomach, liver, spleen, lung, large intestine channel.Relieve internal heat anticancer, cooling blood for hemostasis, detumescent of healing the wounds.
Radix Rehmanniae Preparata, sweet, tepor.Returning liver, kidney channel, yin nourishing of enriching blood, life essence-filling, marrow-benefitting, sweet Wen Zhirun, nourishing YIN benefit essence is with hemopoietic.
Herba Cirsii, removing heat from blood, blood stasis dispelling, hemostasis, there is removing heat from blood removing blood stasis with potent drugs effect.
Fructus Jujubae, nourishing YIN and invigorating YANG, the effect enriched blood.
Fructus Psoraleae, bitter, pungent, warm.Returning kidney, spleen channel, kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, lumbago due to renal deficiency, frequent micturition, children's loses Urine, kidney leaks, warming spleen and stopping diarrha, helping inspiration to relieve asthma.
Herba Cistanches, for impotence due to deficiency of the kidney, seminal emission premature ejaculation and chills and pain of the waist and kness, muscles and bones convulsion is weak.
Radix Glycyrrhizae, and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.
The natural tradition medicinal and edible Chinese medicine above with multiple health care is share, hemoglobinuria can be treated, Improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.Joining of each component is screened by great many of experiments Ratio, scientific and reasonable;And whole preparation technology is rationally and extract drugs rate efficiency is high, the effective one-tenth in raw material can be retained well Point, do not bring any impurity, and sweet mouthfeel into, have no side effect.
The invention has the beneficial effects as follows:
1, the formula of the present invention, has promoting the production of body fluid to quench thirst, gastric acid secretion, helps digest, and health body-building has calm nerves and declines Weak, lessen fatigue, containing various trace elements such as calcium, ferrum, zinc, selenium, sodium etc., raising body immunity, defying age, toxin expelling are supported Face, nourish taste, three-hypers drops, to prevent and treat diabetes and anti-cancer, the aspect such as anticancer the most powerful, regulates human physiological functions.
2, the present invention is rich in anthocyanidin, it is possible to protection human body is from the damage of free radical, it is possible to strengthens blood vessel elasticity, relax Blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect;Immune system ability can be strengthened, there is strong anti-oxidation, resist Suddenly change, alleviate the function such as hepatosis, protection cardiovascular;
3, add the Chinese herbal medicine such as the Rhizoma Atractylodis Macrocephalae, Colla Corii Asini, Poria, Herba Agrimoniae, Radix Rehmanniae Preparata, Herba Cirsii, Radix Glycyrrhizae, Fructus Jujubae and there is Yishen Jianpi treatment blood The functions such as red eggs albiduria disease, raising body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, resisting fatigue.
4, the products taste that the production technology of the present invention and preparation method draw is sour-sweet tasty and refreshing, rich in dendrobium polysaccharide, has The highest health care and medical value, long-term drink can with YIN nourishing skin care, change skin colour, defying age, life lengthening, and Carrying and drink conveniently, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen the beverage of body immunity simultaneously, the shelf-life is up to 1- 2 years.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about The present invention, but and it is not so limited the present invention.
Embodiment 1
The medicated tea of a kind of Yishen Jianpi treatment hemoglobinuria, is made up of the raw material of following weight portion: Radix Ginseng 5 parts, the Radix Astragali 10 Part, Radix Codonopsis 5 parts, Cortex et Radix Polygalae 10 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Radix Angelicae Sinensis 7 parts, 7 parts of Colla Corii Asini, 7 parts of Poria, Herba Agrimoniae 15 parts, 8 parts of Radix Rehmanniae Preparata, Herba Cirsii 10 Part, 10 parts of Radix Glycyrrhizae, 10 parts of Fructus Jujubae, Fructus Psoraleae 8 parts, Herba Cistanches 8 parts, 5 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, Water is appropriate.
The preparation processing method of the medicated tea of a kind of Yishen Jianpi treatment hemoglobinuria, described preparation method includes following Step;
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby;
Fresh for the Herba Dendrobii cleaned up bar is put into microwave oven by B, keeps temperature 50-60 DEG C, carries out heating 10 minutes, further take out Put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content 52 of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time DEG C Chinese liquor, time 15min, the rotating speed of juice extractor is 30r/s;After standing 10 minutes, add the steaming of Herba Dendrobii fresh bar weight 2.5 times Distilled water, for the second time juice extractor time 15min, juice extractor rotating speed is 80r/s, stands 10min;After carry out third time squeeze the juice, add The distilled water of Herba Dendrobii fresh bar weight 3-5 times, time 30min, juice extractor rotating speed is 150r/s, by fresh for Herba Dendrobii bar juice and fiber mistake Filter separate, make the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, broken cell rate reaches more than 80%, obtain new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber;Again new fresh grape is put into after the warm water of 55 DEG C cleans up, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated Stand-by;After new fresh grape cleans up, put into reach in freezer ,-10 ~-20 DEG C of freezings 10 minutes, make Fructus Vitis viniferae freeze, take out certainly After so thawing, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job.
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 120 in tank Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby;
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 6 times of weight, stirring is smashed to 100 mesh, 30-35 DEG C of temperature Degree lower seal preserves 24h, sterilizing, filters, puts into unglazed hermetically sealed can, obtain Matrix Solution standby;Extract the Fructus Vitis viniferae after Matrix Solution It is the cellulase of 0.5-0.7% that skin and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10, keeps 35 DEG C, water soluble dietary fiber can be extracted after 24h enzymolysis further, water soluble dietary fiber is added Matrix Solution and obtains Matrix Solution II;;Rich in anthocyanidin in Pericarpium Vitis viniferae, it is possible to protection human body is from the damage of free radical, it is possible to enhancing blood vessel elasticity, Lax blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect;Immune system ability can be strengthened, there is strong antioxygen Change, mutation, alleviate hepatosis, protection function, Pericarpium Vitis viniferae and the Herba Dendrobii fresh bar fiber such as cardiovascular together with stir smash through Anthocyanidin mentioned by hydromel, can protect the quality of anthocyanidin while farthest extracting anthocyanidin.By water solublity meals Food fiber adds Matrix Solution and obtains Matrix Solution II, can increase effect of the wriggling of the intestines and stomach, it is ensured that metabolic waste is normally discharged External;Adsorb various metabolic waste, be allowed to normally excrete, improve the comprehensive utilization value of Herba Dendrobii.
E, take mix homogeneously after Radix Ginseng, Radix Codonopsis and Radix Angelicae Sinensis cleaning and sterilizing, respectively with 6 times of weight 85% mol ratio ethanol extractions 2 times, each 2 hours, merge 2 Radix Ginsengs, Radix Codonopsis and the ethanol extract of Radix Angelicae Sinensis, receive alcohol and be also evaporated at 40 DEG C the closeest Degree is 1.15-1.35, and the extract preparing Radix Ginseng, Radix Codonopsis and Radix Angelicae Sinensis is standby;
Fructus Psoraleae, Herba Cistanches, the Radix Astragali, Cortex et Radix Polygalae mix and blend are put into super micron mill, carries out micronizing and obtain 300-400 mesh Ultra micro mixing fine powders;
Taking the Rhizoma Atractylodis Macrocephalae, Colla Corii Asini, Poria, Herba Agrimoniae, Radix Rehmanniae Preparata, Herba Cirsii, Radix Glycyrrhizae, Fructus Jujubae, Air Bladder pseudosciaenae seu Acipenser, mix homogeneously adds 30-60 DEG C of warm water leaching After steeping 10 minutes, put into reach in freezer ,-10~-20 DEG C freezing 10-20 minute, form freezing medicine block, by freezing medicine block with surpass Microring array fine powder boiling is extracted 3 times, adds 1-2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 10-20 and divides Clock;Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes;Third time adds 6-10 times amount water, temperature Keep 120-150 DEG C, carry out infusion 30 minutes, filter, be concentrated into the 1/2 of original volume, add carrying of Radix Ginseng, Radix Codonopsis and Radix Angelicae Sinensis Take thing, obtain Matrix Solution III standby;
The hard to bear medicine boiled is pulverized and improves its extract drugs efficiency, make whole formula drug effect farthest be utilized.
F, take Matrix Solution I through instantaneous high-temperature 120 DEG C, 1-2 minute, put into material-compound tank;Take Matrix Solution II through mesh Number be 100 mesh fine filter filter after put into material-compound tank;Take Matrix Solution III again to put into after the fine filter filter that mesh number is 60 mesh In material-compound tank;
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae;Supercritical extraction can be Extract under room temperature 37 DEG C and CO2 gas blanket, effectively prevent oxidation and the loss of heat-sensitive substance.Therefore, The effective ingredient of medicinal plants is remain in extract, and can be high boiling point, low volatility, the easy material being pyrolyzed the lowest Extract under its boiling temperature;
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, and described material-compound tank endobasal-body solution I, matrix are molten Liquid II, Matrix Solution III, the weight proportion of Oleum Vitis viniferae are 10:0.5:6:0.5., seal through bottle capper and load vial In, packaged vial puts into temperature 100~120 DEG C, 1.5MP, sterilization in 15~21 minutes steam ovens, packaging, dress Case, carries and drinks conveniently, and the shelf-life is up to 1-2.
Embodiment 2
A kind of Yishen Jianpi treatment hemoglobinuria medicated tea, be made up of the raw material of following weight portion: Radix Ginseng part, the Radix Astragali 5 parts, Radix Codonopsis 3 parts, Cortex et Radix Polygalae 5 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, Radix Angelicae Sinensis 3 parts, 5 parts of Colla Corii Asini, 5 parts of Poria, Herba Agrimoniae 10 parts, 5 parts of Radix Rehmanniae Preparata, Herba Cirsii 10 parts, 5 parts of Radix Glycyrrhizae, 6 parts of Fructus Jujubae, Fructus Psoraleae 5 parts, Herba Cistanches 5 parts, 5 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 10 parts, Fructus Vitis viniferae 10 parts, Mel, water are fitted Amount.Processing method is with embodiment 1.
Embodiment 3
The medicated tea of a kind of Yishen Jianpi treatment hemoglobinuria, is made up of the raw material of following weight portion: Radix Ginseng 10 parts, the Radix Astragali 15 Part, Radix Codonopsis 9 parts, Cortex et Radix Polygalae 12 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Radix Angelicae Sinensis 9 parts, 12 parts of Colla Corii Asini, 10 parts of Poria, Herba Agrimoniae 30 parts, 10 parts of Radix Rehmanniae Preparata, little Ji 16 parts, 15 parts of Radix Glycyrrhizae, 15 parts of Fructus Jujubae, Fructus Psoraleae 10 parts, Herba Cistanches 10 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 20 parts, Fructus Vitis viniferae 20 Part, Mel, water are appropriate.Processing method is with embodiment 1.
Clinical experiment divides three parts:
(1) animal acute toxicity and chronic toxicity experiment:
1, animal acute toxicity test
Medicine: the embodiment of the present invention 1, embodiment 2 and embodiment 3 medicated tea add the medicated tea powder paste that rice flour is made.
Experimental animal: regular grade NIH mice, body weight 18g ± 2g, male and female half and half.
Method and result:
By three kinds of each 50g of medicated tea, add rice flour.Experiment mice is randomly divided into three groups of male and female half and half, respectively three kinds of medicated tea of feeding Powder is stuck with paste, volume 1ml/10g body weight, and close observation 8 hours is also noted down, and continues to observe 7 days;In 7 days, mice is without death, OK For vivaciously, food ration is as usual, and hair color light is without loose dirt, without fainting from fear addicted to saliva, and eye, mouth, nose, ear and crissum secretions without exception, Without the rotten toe that docks.5 execution of selection from three groups respectively, finding of naked eye: the important organs such as the heart, liver, lung, gastric and thymus, not See abnormal change, show that two kinds of these nutritive powders are all without acute toxicity.
2, long-term toxicity test for animals
Medicine: the embodiment of the present invention 1, embodiment 2 and embodiment 3 gained medicated tea add the medicated tea powder paste that rice flour is made.
Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.
Method and result:
The configuration that three kinds of medicated tea powder are stuck with paste: be divided into high, medium and low three dosage groups, respectively the 200 of edible for patients amount, 100, 50g;Experimental mouse is randomly divided into three groups, and the medicated tea powder that feeding modulates continuously respectively is stuck with paste, and continuous feeding 40 days observes animal General toxic reaction and the order of severity, place after death by rule of operation check each position, and carry out hematology, ALT, BUN and the heart, The pathological examination of the main organs such as liver, spleen, lung, kidney, stomach;
Through long-term feeding, all there is not toxic reaction in two groups of rats.Growth promoter is good.Macroscopic appearance and main organs have no Abnormal.Peripheral hemogram and Serum ALT, BUN compare with matched group without pathologic change.The pathological replacement heart, liver, spleen, lung, kidney, stomach Deng the most significant change, it is understood that through proved by pathology, three kinds of medicated tea powder are stuck with paste and showed animal without chronic toxicity.
By two above toxicity test, it was demonstrated that the medicated tea that the present invention is made by embodiment 1, embodiment 2 and embodiment 3 is Safety, have no side effect, can be used to clinical patients is carried out clinical trial.
3, the embodiment of the present invention drinks effect research:
(1) investigation method:
1. crowd is drunk: general population
2. Ganderwa: 30 days
3. number is drunk: 50 people
4. drinking method: 3 times for each person every day, ante cibum each 500mL
5. index: substantially feel after drinking hematuria the most tired, little, asthenia of both the spleen and kidney, malaise, dizziness, have palpitation, breathe hard, The transference cures such as the abdomen back of the body is ached, food stagnation does not disappears, anorexia, middle gas not province, and mouthfeel is the most sour-sweet for effective;After drinking, sensation is held Fatiguability, little hematuria, asthenia of both the spleen and kidney, malaise, dizziness, have palpitation, breathe hard, the abdomen back of the body is ached, food stagnation does not disappears, anorexia, Middle gas does not save remission, and mouthfeel is the most sour-sweet, is designated as effectively.It is invalid to be then designated as without obvious comfort after drinking.
(2) survey result
Survey result is shown in Table 1.Be test result indicate that by table 1, embodiment 1,2,3 has the respondent of 98% to feel that the present invention is carried The beverage mouthfeel of confession is the most sour-sweet, and above-mentioned clinical symptom disappearance or be eased, the respondent of only 2% drink after without substantially Increase comfort.
The each embodiment of table 1 drinks effect research table
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Embodiment 1 44%(22) 54%(27) 2%(1)
Embodiment 2 42%(21) 56%(28) 2%(1)
Embodiment 3 42%(21) 56%(28) 2%(1)
Embodiment contrast groups A
Comparative example 4,5,6 is added without the nutrition such as new fresh Herba Dendrobii, Fructus Vitis viniferae, Mel, water soluble dietary fiber and Oleum Vitis viniferae and becomes Point, according to the raw material that the Chinese medicine part of embodiment 1,2,3 above is original, preparation for processing is traditional side of boiling Method;The investigation method of using method and using effect is with above.
Table 2 embodiment contrast groups A drinks effect research
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Comparative example 4 36%(18) 40%(20) 24%(12)
Comparative example 5 40%(20) 40%(20) 20%(10)
Comparative example 6 46%(23) 34%(17) 20%(10)
Embodiment contrast groups B
Comparative example 7,8,9 is added without the nutrition such as new fresh Herba Dendrobii, Fructus Vitis viniferae, Mel, water soluble dietary fiber and Oleum Vitis viniferae and becomes Point, according to the raw material that the Chinese medicine part of embodiment 1,2,3 above is original, preparation for processing uses in embodiment 1 The preparation processing method of step E;The investigation method of using method and using effect is with above.
Table 3 embodiment contrast groups B drinks effect research
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Comparative example 7 32%(16) 56%(28) 12%(6)
Comparative example 8 28%(14) 52%(31) 10%(5)
Comparative example 9 36%(18) 52%(26) 12%(6)
Embodiment contrast groups C
The processing method of comparative example 10,11,12 respectively corresponding embodiment 1,2,3 and formula, different be formula in Without Air Bladder pseudosciaenae seu Acipenser composition;The investigation method of using method and using effect is with above.
Table 4 embodiment contrast groups C drinks effect research
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Comparative example 10 44%(22) 46%(23) 10%(5)
Comparative example 11 38%(19) 50%(25) 12%(6)
Comparative example 12 40%(20) 48%(24) 12%(6)
Conclusion:
Contrasted by table 2 and table 1 and can be seen that
The inefficient number of embodiment contrast groups A is about 10 times of embodiment 1,2,3;This shows Chinese crude drug formula of the present invention And between the nutritional labeling such as water soluble dietary fiber and Oleum Vitis viniferae, creating the most collaborative pharmacological action, aqueous soluble dietary is fine Dimension increases effect of the wriggling of the intestines and stomach and promotes the human body absorption to ingredient, it is ensured that metabolic waste normally excretes, additionally The anthocyanidin that contains in Pericarpium Vitis viniferae, resveratrol, have strong anti-oxidation, mutation, alleviate hepatosis, protection cardiovascular etc. Function, strengthens immune system ability;Associate with Chinese medicine and improve assimilation effect and improve the mouthfeel of Chinese medicine, through the essence of the present invention simultaneously The extraction of heart configuration and at utmost ingredient, Chinese crude drug formula of the present invention and preparation method occur in that beat all technology Effect.
Table 2 and table 3 contrast can be seen that
About inefficient number is embodiment contrast groups B 2 times of embodiment contrast groups A, embodiment contrast groups B and traditional Embodiment contrast groups A of boiling method has compared significant raising at therapeutic effect, and this shows that Chinese crude drug of the present invention is through step The preparation processing method of rapid E has had significant raising than traditional boiling method, the extraction degree of active ingredient.
Table 1 is compared with table 4:
The formula of embodiment contrast groups C does not contains Air Bladder pseudosciaenae seu Acipenser, and the invalid number of embodiment contrast groups C is 5 times of left sides of embodiment 1,2,3 Right;And effective percentage number has and has declined;Air Bladder pseudosciaenae seu Acipenser can strengthen gastrointestinal digestive and absorptive functions, improves appetite, is conducive to anti- Control the diseases such as inappetence, anorexia, dyspepsia, abdominal distention, constipation, show Air Bladder pseudosciaenae seu Acipenser serve in formula collaborative and priming return through Effect, Air Bladder pseudosciaenae seu Acipenser application effect achieves unexpected technique effect.
In sum, the medicated tea of a kind of Yishen Jianpi treatment hemoglobinuria that the present invention provides has sour-sweet mouth Sense, have the most again simultaneously treatment hematuria the most tired, little, asthenia of both the spleen and kidney, malaise, dizziness, have palpitation, breathe hard, the abdomen back of the body is ached, The merit that food stagnation does not disappears, anorexia, middle gas do not save, improves body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, fall three High, to prevent and treat diabetes and anti-cancer, the aspect such as anticancer the most powerful.And all raw materials is all from medicine-food two-purpose natural plants, nontoxic Side effect.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (7)

1. the medicated tea of a Yishen Jianpi treatment hemoglobinuria, it is characterised in that be made up of the raw material of following weight portion: people Ginseng 1-10 part, Radix Astragali 5-15 part, Radix Codonopsis 3-9 part, Cortex et Radix Polygalae 5-12 part, Rhizoma Atractylodis Macrocephalae 3-9 part, Radix Angelicae Sinensis 3-9 part, Colla Corii Asini 5-12 part, Poria 5-10 part, Herba Agrimoniae 10-30 part, Radix Rehmanniae Preparata 5-10 part, Herba Cirsii 10-16 part, Radix Glycyrrhizae 5-15 part, Fructus Jujubae 6-15 part, Fructus Psoraleae 5-10 Part, Herba Cistanches 5-10 part, Air Bladder pseudosciaenae seu Acipenser 5-10 part, new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae 10-20 part, Mel, water are appropriate.
The medicated tea of a kind of Yishen Jianpi the most according to claim 1 treatment hemoglobinuria, it is characterised in that by following The raw material of weight portion is made: Radix Ginseng 5 parts, the Radix Astragali 10 parts, Radix Codonopsis 5 parts, Cortex et Radix Polygalae 10 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Radix Angelicae Sinensis 7 parts, 7 parts of Colla Corii Asini, Fu Siberian cocklebur 7 parts, Herba Agrimoniae 15 parts, 8 parts of Radix Rehmanniae Preparata, Herba Cirsii 10 parts, 10 parts of Radix Glycyrrhizae, 10 parts of Fructus Jujubae, Fructus Psoraleae 8 parts, Herba Cistanches 8 parts, Air Bladder pseudosciaenae seu Acipenser 5 Part, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
The medicated tea of a kind of Yishen Jianpi the most according to claim 1 treatment hemoglobinuria, it is characterised in that by following The raw material of weight portion is made: Radix Ginseng 5 parts, the Radix Astragali 5 parts, Radix Codonopsis 3 parts, Cortex et Radix Polygalae 5 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, Radix Angelicae Sinensis 3 parts, 5 parts of Colla Corii Asini, Poria 5 parts, Herba Agrimoniae 10 parts, 5 parts of Radix Rehmanniae Preparata, Herba Cirsii 10 parts, 5 parts of Radix Glycyrrhizae, 6 parts of Fructus Jujubae, Fructus Psoraleae 5 parts, Herba Cistanches 5 parts, 5 parts of Air Bladder pseudosciaenae seu Acipenser, New fresh Herba Dendrobii 10 parts, Fructus Vitis viniferae 10 parts, Mel, water are appropriate.
The medicated tea of a kind of Yishen Jianpi the most according to claim 1 treatment hemoglobinuria, it is characterised in that by following The raw material of weight portion is made: Radix Ginseng 10 parts, the Radix Astragali 15 parts, Radix Codonopsis 9 parts, Cortex et Radix Polygalae 12 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Radix Angelicae Sinensis 9 parts, 12 parts of Colla Corii Asini, 10 parts of Poria, Herba Agrimoniae 30 parts, 10 parts of Radix Rehmanniae Preparata, Herba Cirsii 16 parts, 15 parts of Radix Glycyrrhizae, 15 parts of Fructus Jujubae, Fructus Psoraleae 10 parts, Herba Cistanches 10 Part, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 20 parts, Fructus Vitis viniferae 20 parts, Mel, water are appropriate.
5. the preparation processing method of the medicated tea of a Yishen Jianpi treatment hemoglobinuria, it is characterised in that include following step Suddenly;
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby;
B, fresh for the Herba Dendrobii cleaned up bar is put into microwave oven, keep temperature 50-60 DEG C, carry out heating 10 minutes, then take Go out to put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time The Chinese liquor of 52-60 DEG C, time 10-15min, the rotating speed of juice extractor is 20~30r/s;After standing 10 minutes, add the fresh bar of Herba Dendrobii The distilled water of weight 2-3 times, for the second time juice extractor time 10-15min, juice extractor rotating speed is 80~100r/s, stands 10min; After carry out third time squeeze the juice, add Herba Dendrobii fresh bar weight 3-5 times distilled water, time 20-30min, juice extractor rotating speed be 100~ 150r/s, separates fresh for Herba Dendrobii bar juice with fiber filter, makes the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, cell damage Rate reaches more than 80%, obtains new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber;The warm water that new fresh grape is put into 50-60 DEG C again cleans dry After Jing, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated stand-by;
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 100-150 in tank Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby;
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 5-10 times of weight, stirring is smashed to 100 mesh, at 30-35 Seal at a temperature of DEG C and preserve 24h, sterilizing, filter, put into unglazed hermetically sealed can, obtain Matrix Solution standby;After extracting Matrix Solution It is the cellulase of 0.5-0.7% that Pericarpium Vitis viniferae and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10, Keep 35 DEG C, water soluble dietary fiber can be extracted further after 24h enzymolysis, water soluble dietary fiber is added Matrix Solution Obtain Matrix Solution II;
E, take mix homogeneously after Radix Ginseng, Radix Codonopsis and Radix Angelicae Sinensis cleaning and sterilizing, respectively with 6 times of weight 85% mol ratio ethanol extractions 2 times, Each 2 hours, merge 2 Radix Ginsengs, Radix Codonopsis and the ethanol extract of Radix Angelicae Sinensis, receive alcohol and be evaporated to relative density at 40 DEG C and be 1.15-1.35, the extract preparing Radix Ginseng, Radix Codonopsis and Radix Angelicae Sinensis is standby;
Fructus Psoraleae, Herba Cistanches, the Radix Astragali, Cortex et Radix Polygalae mix and blend are put into super micron mill, carries out micronizing and obtain 300-400 mesh Ultra micro mixing fine powders;
Taking the Rhizoma Atractylodis Macrocephalae, Colla Corii Asini, Poria, Herba Agrimoniae, Radix Rehmanniae Preparata, Herba Cirsii, Radix Glycyrrhizae, Fructus Jujubae, Air Bladder pseudosciaenae seu Acipenser, mix homogeneously adds 30-60 DEG C of warm water leaching After steeping 10 minutes, put into reach in freezer ,-10~-20 DEG C freezing 10-20 minute, form freezing medicine block, by freezing medicine block with surpass Microring array fine powder boiling is extracted 3 times, adds 1-2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 10-20 and divides Clock;Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes;Third time adds 6-10 times amount water, temperature Keep 120-150 DEG C, carry out infusion 30 minutes, filter, be concentrated into the 1/2 of original volume, add carrying of Radix Ginseng, Radix Codonopsis and Radix Angelicae Sinensis Take thing, obtain Matrix Solution III standby;
F, take Matrix Solution I through instantaneous high-temperature 110-130 DEG C, 1-2 minute, put into material-compound tank;Take Matrix Solution II through mesh Number be 100 mesh fine filter filter after put into material-compound tank;Take Matrix Solution III again to put into after the fine filter filter that mesh number is 60 mesh In material-compound tank;
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae;
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, seal through bottle capper and load in vial, Packaged vial puts into temperature 100~120 DEG C, 1.5MP, sterilization in 15~21 minutes steam ovens, packaging, vanning.
The preparation processing method of the medicated tea of a kind of Yishen Jianpi the most according to claim 5 treatment hemoglobinuria, its It is characterised by, step B) in, after new fresh grape cleans up, put into reach in freezer ,-10~-20 DEG C freezing 5-10 minute, make Fructus Vitis viniferae freezes, and after taking out nature defrosting, then carries out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job.
The preparation processing method of the medicated tea of a kind of Yishen Jianpi the most according to claim 5 treatment hemoglobinuria, its Be characterised by, step H) described in material-compound tank endobasal-body solution I, Matrix Solution II, Matrix Solution III, the weight of Oleum Vitis viniferae Proportioning is 10:0.2~0.8:5~10:0.5.
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