CN106166230A - The medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia and preparation processing method - Google Patents

The medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia and preparation processing method Download PDF

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CN106166230A
CN106166230A CN201610234285.4A CN201610234285A CN106166230A CN 106166230 A CN106166230 A CN 106166230A CN 201610234285 A CN201610234285 A CN 201610234285A CN 106166230 A CN106166230 A CN 106166230A
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parts
radix
vitis viniferae
herba dendrobii
fresh
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温从字
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Zhejiang Yu Chen Pharmaceutical Co Ltd
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Zhejiang Yu Chen Pharmaceutical Co Ltd
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
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Abstract

The invention discloses the medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia of the present invention, be made up of the raw material of following weight portion: 10 30 parts of Cornu Bovis seu Bubali, 5 15 parts of the Radix Rehmanniae, Cortex Moutan 39 parts, Radix Paeoniae Rubra 5 12 parts, Radix Arnebiae (Radix Lithospermi) 39 parts, the Rhizoma Anemarrhenae 39 parts, Radix Adenophorae (Radix Glehniae) 5 12 parts, Flos Sophorae 5 10 parts, Folium Isatidis 10 30 parts, Radix Isatidis 5 10 parts, Herba Agrimoniae 10 16 parts, Fructus Forsythiae 5 15 parts, Caulis Polygoni Multiflori 6 15 parts, Cortex Albiziae 5 10 parts, Cacumen Platycladi 5 10 parts, Radix Ophiopogonis 5 10 parts, 10 15 parts of Colla Corii Asini.The invention have the advantage that inventive formulation clearing away heat and cooling blood can treat that pyretic toxicity enters blood, heat in blood hinders that network causes treating thrombocytopenia, anorexia, middle gas do not save, and improves body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.

Description

The medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia and preparation processing method
Technical field
The present invention relates to the medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia, in particular, relate to a kind of clear The herb tea formula of hot removing heat from blood treatment thrombocytopenia and preparation method thereof technical field.
Background technology
Thrombocytopenia is that (platelet function is not due to platelet counts minimizing (thrombocytopenia) or hypofunction Tampon entirely) is caused to be formed bad and hemorrhage and cause.Platelet count is less than 140,000 ~ 400,000/μ l. platelet normal range Reduce disease may come from platelet produce deficiency, spleen to hematoblastic detention, traditional Chinese medical science angle think by pyretic toxicity enter blood, heat in blood wound Network causes the thrombocytopenia such as yellowish urine, constipation, malaise, gingival hemorrhage, food stagnation does not disappears, anorexia, middle gas do not save, fatigue Disease symptom；Clearing away heat and cooling blood can be passed through, treat thrombocytopenia.
The most traditional beverage, only focuses on mouthfeel, is of low nutritive value, and does not have a clearing away heat and cooling blood, treatment thrombocytopenia, Improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, drop three-hypers, prevent and treat diabetes and anti-cancer, the aspect such as anticancer Function, it is impossible to releasing the sufferings of client, and traditional herbal tea is by Traditional medicine infusion, flavour of a drug weight mouthfeel is poor, it is impossible to preserve for a long time.Mesh Not yet occur a kind of in good taste on front market, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen the drink of body immunity simultaneously Material.
Summary of the invention
The present invention is directed to the deficiency of existing product, and provide a kind of fresh juice beverage to regulate the effect of human physiological functions, This beverage have be easily absorbed by the human body, medicinal function is notable, delicious flavour, good mouthfeel, improve self and increase the wriggling of the intestines and stomach, Cure the disease the medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia simultaneously strengthening the advantage such as body immunity.
The medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia, is made up of the raw material of following weight portion: Cornu Bovis seu Bubali 10-30 Part, Radix Rehmanniae 5-15 part, Cortex Moutan 3-9 part, Radix Paeoniae Rubra 5-12 part, Radix Arnebiae (Radix Lithospermi) 3-9 part, Rhizoma Anemarrhenae 3-9 part, Radix Adenophorae (Radix Glehniae) 5-12 part, Flos Sophorae 5-10 Part, Folium Isatidis 10-30 part, Radix Isatidis 5-10 part, Herba Agrimoniae 10-16 part, Fructus Forsythiae 5-15 part, Caulis Polygoni Multiflori 6-15 part, Cortex Albiziae 5- 10 parts, Cacumen Platycladi 5-10 part, Radix Ophiopogonis 5-10 part, Colla Corii Asini 10-15 part, Air Bladder pseudosciaenae seu Acipenser 5-10 part, new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae 10-20 Part, Mel, water are appropriate.
The preparation processing method of the medicated tea of described a kind of clearing away heat and cooling blood treatment thrombocytopenia, comprises the following steps；
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby；
B, fresh for the Herba Dendrobii cleaned up bar is put into microwave oven, keep temperature 50-60 DEG C, carry out heating 10 minutes, then take Go out to put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time The Chinese liquor of 52-60 DEG C, time 10-15min, the rotating speed of juice extractor is 20～30r/s；After standing 10 minutes, add the fresh bar of Herba Dendrobii The distilled water of weight 2-3 times, for the second time juice extractor time 10-15min, juice extractor rotating speed is 80～100r/s, stands 10min； After carry out third time squeeze the juice, add Herba Dendrobii fresh bar weight 3-5 times distilled water, time 20-30min, juice extractor rotating speed be 100～ 150r/s, separates fresh for Herba Dendrobii bar juice with fiber filter, makes the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, cell damage Rate reaches more than 80%, obtains new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber；The warm water that new fresh grape is put into 50-60 DEG C again cleans dry After Jing, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated stand-by；
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 100-150 in tank Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby；
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 5-10 times of weight, stirring is smashed to 100 mesh, at 30-35 Seal at a temperature of DEG C and preserve 24h, sterilizing, filter, put into unglazed hermetically sealed can, obtain Matrix Solution standby；After extracting Matrix Solution It is the cellulase of 0.5-0.7% that Pericarpium Vitis viniferae and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10, Keep 35 DEG C, water soluble dietary fiber can be extracted further after 24h enzymolysis, water soluble dietary fiber is added Matrix Solution Obtain Matrix Solution II；
E, take mix homogeneously after Radix Adenophorae (Radix Glehniae), Caulis Polygoni Multiflori cleaning and sterilizing, respectively with 6 times of weight 85% mol ratio ethanol extractions 2 times, every time 2 hours, merge 2 Radix Adenophorae (Radix Glehniae), Caulis Polygoni Multiflori ethanol extracts, receive alcohol and to be evaporated to relative density at 40 DEG C be 1.15-1.35, Prepare Radix Adenophorae (Radix Glehniae), Caulis Polygoni Multiflori extract standby；
Cornu Bovis seu Bubali, Radix Paeoniae Rubra mix and blend are put into super micron mill, carries out micronizing and obtain the ultra micro mixing of 300-400 mesh carefully Powder；
Take Cortex Moutan, Radix Arnebiae (Radix Lithospermi), the Rhizoma Anemarrhenae, Flos Sophorae, Folium Isatidis, Radix Isatidis, Herba Agrimoniae, Fructus Forsythiae, Cortex Albiziae, Cacumen Platycladi, Radix Ophiopogonis, Ah Glue, Air Bladder pseudosciaenae seu Acipenser, after mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes, put into reach in freezer, at the freezing 10-20 in-10～-20 DEG C Minute, form freezing medicine block, freezing medicine block and ultra micro mixing fine powders boiling extracted 3 times, adds 1-2 times amount water for the first time, Temperature keeps 100-120 DEG C, carries out infusion 10-20 minute；Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, endures Boil 10 minutes；Third time adds 6-10 times amount water, and temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and is concentrated into original The 1/2 of volume, adds Radix Adenophorae (Radix Glehniae), the extract of Caulis Polygoni Multiflori, obtains Matrix Solution III standby；
F, take Matrix Solution I through instantaneous high-temperature 110-130 DEG C, 1-2 minute, put into material-compound tank；Take Matrix Solution II through mesh Number be 100 mesh fine filter filter after put into material-compound tank；Take Matrix Solution III again to put into after the fine filter filter that mesh number is 60 mesh In material-compound tank；
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae；
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, seal through bottle capper and load in vial, Packaged vial puts into temperature 100～120 DEG C, 1.5MP, sterilization in 15～21 minutes steam ovens, packaging, vanning.
Further: step B) in, after new fresh grape cleans up, put into reach in freezer ,-10～-20 DEG C freezing 5-10 minute, Make Fructus Vitis viniferae freeze, after taking out nature defrosting, then carry out Fructus Vitis viniferae meat and Pericarpium Vitis viniferae detached job.
Further: step H) described in material-compound tank endobasal-body solution I, Matrix Solution II, Matrix Solution III, Oleum Vitis viniferae Weight proportion be 10:0.2～0.8:5～10:0.5.
Cornu Bovis seu Bubali, the angle of bovid.Effect: refrigerant hemostasis, heat-clearing and toxic substances removing.
The Radix Rehmanniae, sweet in the mouth, cold.Hemopoietic removing heat from blood, cures mainly folding and falls, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fills out bone marrow, long muscle.
Cortex Moutan, pungent, bitter, be slightly cold.GUIXIN, liver, kidney channel.For the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, there is clearing away heat and cooling blood effect.
Radix Paeoniae Rubra, bitter, it is slightly cold.Return Liver Channel.There is clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling.
Radix Arnebiae (Radix Lithospermi), removing heat from blood, invigorate blood circulation, heat clearing away, removing toxic substances.
The Rhizoma Anemarrhenae, returns lung, stomach, kidney channel.Clearing away heat-fire is nourshing Yin and drynsessmoistening prescription.Calentura excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat disappears Yearningly, dryness of the intestine constipation.
Radix Adenophorae (Radix Glehniae), sweet in the mouth is sweet, nourishing YIN and clearing away lung-heat, expelling phlegm for arresting cough.Cure mainly dryness of the lung dry cough, consumption of body fluid caused by febrile disease.
Flos Sophorae, has effect of cooling blood for hemostasis, can be used for spitting blood, epistaxis, hematuria, stranguria with blood, have blood in stool, hemorrhoidal bleeding, metrorrhagia etc. Multiple hemorrhage.Modern pharmacological research shows, Flos Sophorae has blood pressure lowering, excited heart, improves myocardial circulation, prevention of arterial hardening Effect, be the good health product of cardiovascular system diseases patient.
Folium Isatidis, bitter in the mouth, cold in nature, return liver, the heart, stomach, spleen channel.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.
Radix Isatidis, heat-clearing and toxic substances removing, removing heat from blood;For warming heating, to send out speckle, anemopyretic cold, swelling throat rotten.
Herba Agrimoniae is bitter, cool.Return stomach, liver, spleen, lung, large intestine channel.Relieve internal heat anticancer, cooling blood for hemostasis, detumescent of healing the wounds.
Fructus Forsythiae, heat clearing away, removing toxic substances, eliminating stagnation, detumescence.
Caulis Polygoni Multiflori, sweet micro-hardship, flat.Bitter in the mouth, warm in nature, nontoxic, nourish heart, calm the nerves, dredging collateral, dispel the wind, control insomnia, impairment caused by overstrain is many Antiperspirant, blood deficiency general pain.
Cortex Albiziae, sweet, Wen Ping, the dissipating depression of QI that nourishes heart, tranquilizing the mind effect.
Cacumen Platycladi, cooling blood for hemostasis, preventing phlegm from forming and stopping coughing, it is used for spitting blood, epistaxis, spitting of blood, have blood in stool, metrostaxis, cough due to lung-heat, blood Hot alopecia, early whitening of beard and hair.
Radix Ophiopogonis, sweet in the mouth, micro-hardship, it is slightly cold, GUIXIN, lung, stomach warp, YIN nourishing and the production of body fluid promoting, nourishing the lung to arrest cough: few for Tianjin of lung-stomach yin deficiency Thirsty, dry cough spitting of blood；The palpitation and being susceptible to fright of insufficiency of heart-YIN and calentura later stage consumption of body fluid by heat etc. are demonstrate,proved.
Colla Corii Asini, YIN nourishing of enriching blood, moisturize, hemostasis.For blood deficiency and yellow complexion, dizziness cardiopalmus, dysphoria and insomnia, xeropulmonary cough.
The natural tradition medicinal and edible Chinese medicine above with multiple health care is share, clearing away heat and cooling blood, treat platelet Reduce disease, improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.Each by great many of experiments screening The proportioning of component, scientific and reasonable；And whole preparation technology is rationally and extract drugs rate efficiency is high, can retain in raw material well Effective ingredient, do not bring any impurity, and sweet mouthfeel into, have no side effect.
The invention has the beneficial effects as follows:
1, the formula of the present invention, has promoting the production of body fluid to quench thirst, gastric acid secretion, helps digest, and health body-building has calm nerves and declines Weak, lessen fatigue, containing various trace elements such as calcium, ferrum, zinc, selenium, sodium etc., raising body immunity, defying age, toxin expelling are supported Face, nourish taste, three-hypers drops, to prevent and treat diabetes and anti-cancer, the aspect such as anticancer the most powerful, regulates human physiological functions.
2, the present invention is rich in anthocyanidin, it is possible to protection human body is from the damage of free radical, it is possible to strengthens blood vessel elasticity, relax Blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect；Immune system ability can be strengthened, there is strong anti-oxidation, resist Suddenly change, alleviate the function such as hepatosis, protection cardiovascular；
3, add the Chinese herbal medicine such as Cortex Moutan, Radix Arnebiae (Radix Lithospermi), the Rhizoma Anemarrhenae, Flos Sophorae, Folium Isatidis, Radix Isatidis and there is clearing away heat and cooling blood, treat platelet Reduce disease, improve the functions such as body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, resisting fatigue.
4, the products taste that the production technology of the present invention and preparation method draw is sour-sweet tasty and refreshing, rich in dendrobium polysaccharide, has The highest health care and medical value, long-term drink can with YIN nourishing skin care, change skin colour, defying age, life lengthening, and Carrying and drink conveniently, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen the beverage of body immunity simultaneously, the shelf-life is up to 1- 2 years.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about The present invention, but and it is not so limited the present invention.
Embodiment 1
The medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia, is made up of the raw material of following weight portion: 20 parts of Cornu Bovis seu Bubali, the Radix Rehmanniae 10 Part, Cortex Moutan 8 parts, Radix Paeoniae Rubra 10 parts, Radix Arnebiae (Radix Lithospermi) 8 parts, the Rhizoma Anemarrhenae 8 parts, Radix Adenophorae (Radix Glehniae) 8 parts, Flos Sophorae 8 parts, Folium Isatidis 20 parts, Radix Isatidis 8 parts, celestial being Crane grass 12 parts, Fructus Forsythiae 12 parts, Caulis Polygoni Multiflori 12 parts, Cortex Albiziae 8 parts, Cacumen Platycladi 8 parts, Radix Ophiopogonis 8 parts, 12 parts of Colla Corii Asini, 8 parts of Air Bladder pseudosciaenae seu Acipenser, new Fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
The preparation processing method of the medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia, described preparation method includes following Step；
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby；
Fresh for the Herba Dendrobii cleaned up bar is put into microwave oven by B, keeps temperature 50-60 DEG C, carries out heating 10 minutes, further take out Put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content 52 of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time DEG C Chinese liquor, time 15min, the rotating speed of juice extractor is 30r/s；After standing 10 minutes, add the steaming of Herba Dendrobii fresh bar weight 2.5 times Distilled water, for the second time juice extractor time 15min, juice extractor rotating speed is 80r/s, stands 10min；After carry out third time squeeze the juice, add The distilled water of Herba Dendrobii fresh bar weight 3-5 times, time 30min, juice extractor rotating speed is 150r/s, by fresh for Herba Dendrobii bar juice and fiber mistake Filter separate, make the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, broken cell rate reaches more than 80%, obtain new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber；Again new fresh grape is put into after the warm water of 55 DEG C cleans up, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated Stand-by；After new fresh grape cleans up, put into reach in freezer ,-10 ~-20 DEG C of freezings 10 minutes, make Fructus Vitis viniferae freeze, take out certainly After so thawing, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job.
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 120 in tank Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby；
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 6 times of weight, stirring is smashed to 100 mesh, 30-35 DEG C of temperature Degree lower seal preserves 24h, sterilizing, filters, puts into unglazed hermetically sealed can, obtain Matrix Solution standby；Extract the Fructus Vitis viniferae after Matrix Solution It is the cellulase of 0.5-0.7% that skin and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10, keeps 35 DEG C, water soluble dietary fiber can be extracted after 24h enzymolysis further, water soluble dietary fiber is added Matrix Solution and obtains Matrix Solution II；；Rich in anthocyanidin in Pericarpium Vitis viniferae, it is possible to protection human body is from the damage of free radical, it is possible to enhancing blood vessel elasticity, Lax blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect；Immune system ability can be strengthened, there is strong antioxygen Change, mutation, alleviate hepatosis, protection function, Pericarpium Vitis viniferae and the Herba Dendrobii fresh bar fiber such as cardiovascular together with stir smash through Anthocyanidin mentioned by hydromel, can protect the quality of anthocyanidin while farthest extracting anthocyanidin.By water solublity meals Food fiber adds Matrix Solution and obtains Matrix Solution II, can increase effect of the wriggling of the intestines and stomach, it is ensured that metabolic waste is normally discharged External；Adsorb various metabolic waste, be allowed to normally excrete, improve the comprehensive utilization value of Herba Dendrobii.
E, take mix homogeneously after Radix Adenophorae (Radix Glehniae), Caulis Polygoni Multiflori cleaning and sterilizing, respectively with 6 times of weight 85% mol ratio ethanol extractions 2 times, Each 2 hours, merge 2 Radix Adenophorae (Radix Glehniae), Caulis Polygoni Multiflori ethanol extracts, receive alcohol and to be evaporated to relative density at 40 DEG C be 1.15- 1.35, prepare Radix Adenophorae (Radix Glehniae), Caulis Polygoni Multiflori extract standby；
Cornu Bovis seu Bubali, Radix Paeoniae Rubra mix and blend are put into super micron mill, carries out micronizing and obtain the ultra micro mixing of 300-400 mesh carefully Powder；
Take Cortex Moutan, Radix Arnebiae (Radix Lithospermi), the Rhizoma Anemarrhenae, Flos Sophorae, Folium Isatidis, Radix Isatidis, Herba Agrimoniae, Fructus Forsythiae, Cortex Albiziae, Cacumen Platycladi, Radix Ophiopogonis, Ah Glue, Air Bladder pseudosciaenae seu Acipenser, after mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes, put into reach in freezer, at the freezing 10-20 in-10～-20 DEG C Minute, form freezing medicine block, freezing medicine block and ultra micro mixing fine powders boiling extracted 3 times, adds 1-2 times amount water for the first time, Temperature keeps 100-120 DEG C, carries out infusion 10-20 minute；Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, endures Boil 10 minutes；Third time adds 6-10 times amount water, and temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and is concentrated into original The 1/2 of volume, adds Radix Adenophorae (Radix Glehniae), the extract of Caulis Polygoni Multiflori, obtains Matrix Solution III standby；
The hard to bear medicine boiled is pulverized and improves its extract drugs efficiency, make whole formula drug effect farthest be utilized.
F, take Matrix Solution I through instantaneous high-temperature 120 DEG C, 1-2 minute, put into material-compound tank；Take Matrix Solution II through mesh Number be 100 mesh fine filter filter after put into material-compound tank；Take Matrix Solution III again to put into after the fine filter filter that mesh number is 60 mesh In material-compound tank；
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae；Supercritical extraction can be Extract under room temperature 37 DEG C and CO2 gas blanket, effectively prevent oxidation and the loss of heat-sensitive substance.Therefore, The effective ingredient of medicinal plants is remain in extract, and can be high boiling point, low volatility, the easy material being pyrolyzed the lowest Extract under its boiling temperature；
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, and described material-compound tank endobasal-body solution I, matrix are molten Liquid II, Matrix Solution III, the weight proportion of Oleum Vitis viniferae are 10:0.5:6:0.5., seal through bottle capper and load vial In, packaged vial puts into temperature 100～120 DEG C, 1.5MP, sterilization in 15～21 minutes steam ovens, packaging, dress Case, carries and drinks conveniently, and the shelf-life is up to 1-2.
Embodiment 2
The medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia, is made up of the raw material of following weight portion: 10 parts of Cornu Bovis seu Bubali, the Radix Rehmanniae 5 Part, Cortex Moutan 3 parts, Radix Paeoniae Rubra 5 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, the Rhizoma Anemarrhenae 3 parts, Radix Adenophorae (Radix Glehniae) 5 parts, Flos Sophorae 5 parts, Folium Isatidis 10 parts, Radix Isatidis 5 parts, celestial being Crane grass 10 parts, Fructus Forsythiae 5 parts, Caulis Polygoni Multiflori 6 parts, Cortex Albiziae 5 parts, Cacumen Platycladi 5 parts, Radix Ophiopogonis 5 parts, 10 parts of Colla Corii Asini, 5 parts of Air Bladder pseudosciaenae seu Acipenser, fresh Herba Dendrobii 10 parts, Fructus Vitis viniferae 10 parts, Mel, water are appropriate.Processing method is with embodiment 1.
Embodiment 3
The medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia, is made up of the raw material of following weight portion: 30 parts of Cornu Bovis seu Bubali, the Radix Rehmanniae 15 Part, Cortex Moutan 9 parts, Radix Paeoniae Rubra 12 parts, Radix Arnebiae (Radix Lithospermi) 9 parts, the Rhizoma Anemarrhenae 9 parts, Radix Adenophorae (Radix Glehniae) 12 parts, Flos Sophorae 10 parts, Folium Isatidis 30 parts, Radix Isatidis 10 Part, Herba Agrimoniae 16 parts, Fructus Forsythiae 15 parts, Caulis Polygoni Multiflori 15 parts, Cortex Albiziae 10 parts, Cacumen Platycladi 10 parts, Radix Ophiopogonis 10 parts, 15 parts of Colla Corii Asini, fish Fish glue 10 parts, new fresh Herba Dendrobii 20 parts, Fructus Vitis viniferae 20 parts, Mel, water are appropriate.Processing method is with embodiment 1.
Clinical experiment divides three parts:
(1) animal acute toxicity and chronic toxicity experiment:
1, animal acute toxicity test
Medicine: the embodiment of the present invention 1, embodiment 2 and embodiment 3 medicated tea add the medicated tea powder paste that rice flour is made.
Experimental animal: regular grade NIH mice, body weight 18g ± 2g, male and female half and half.
Method and result:
By three kinds of each 50g of medicated tea, add rice flour.Experiment mice is randomly divided into three groups of male and female half and half, respectively three kinds of medicated tea of feeding Powder is stuck with paste, volume 1ml/10g body weight, and close observation 8 hours is also noted down, and continues to observe 7 days；In 7 days, mice is without death, OK For vivaciously, food ration is as usual, and hair color light is without loose dirt, without fainting from fear addicted to saliva, and eye, mouth, nose, ear and crissum secretions without exception, Without the rotten toe that docks.5 execution of selection from three groups respectively, finding of naked eye: the important organs such as the heart, liver, lung, gastric and thymus, not See abnormal change, show that two kinds of these nutritive powders are all without acute toxicity.
2, long-term toxicity test for animals
Medicine: the embodiment of the present invention 1, embodiment 2 and embodiment 3 gained medicated tea add the medicated tea powder paste that rice flour is made.
Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.
Method and result:
The configuration that three kinds of medicated tea powder are stuck with paste: be divided into high, medium and low three dosage groups, respectively the 200 of edible for patients amount, 100, 50g；Experimental mouse is randomly divided into three groups, and the medicated tea powder that feeding modulates continuously respectively is stuck with paste, and continuous feeding 40 days observes animal General toxic reaction and the order of severity, place after death by rule of operation check each position, and carry out hematology, ALT, BUN and the heart, The pathological examination of the main organs such as liver, spleen, lung, kidney, stomach；
Through long-term feeding, all there is not toxic reaction in two groups of rats.Growth promoter is good.Macroscopic appearance and main organs have no Abnormal.Peripheral hemogram and Serum ALT, BUN compare with matched group without pathologic change.The pathological replacement heart, liver, spleen, lung, kidney, stomach Deng the most significant change, it is understood that through proved by pathology, three kinds of medicated tea powder are stuck with paste and showed animal without chronic toxicity.
By two above toxicity test, it was demonstrated that the medicated tea that the present invention is made by embodiment 1, embodiment 2 and embodiment 3 is Safety, have no side effect, can be used to clinical patients is carried out clinical trial.
3, the embodiment of the present invention drinks effect research:
(1) investigation method:
1. crowd is drunk: general population
2. Ganderwa: 30 days
3. number is drunk: 50 people
4. drinking method: 3 times for each person every day, ante cibum each 500mL
5. index: after drinking, substantially sensation is the most tired, pyretic toxicity enters blood, heat in blood hinders network, yellowish urine, constipation, malaise, gingiva The transference cures such as hemorrhage, food stagnation does not disappears, anorexia, middle gas not province, and mouthfeel is the most sour-sweet for effective；Feel the most tired after drinking Labor, pyretic toxicity enter blood, heat in blood hinders network, yellowish urine, constipation, malaise, gingival hemorrhage, food stagnation does not disappears, anorexia, middle gas do not save disease Shape is alleviated, and mouthfeel is the most sour-sweet, is designated as effectively.It is invalid to be then designated as without obvious comfort after drinking.
(2) survey result
Survey result is shown in Table 1.Be test result indicate that by table 1, embodiment 1,2,3 has the respondent of 98% to feel that the present invention is carried The beverage mouthfeel of confession is the most sour-sweet, and above-mentioned clinical symptom disappearance or be eased, the respondent of only 2% drink after without substantially Increase comfort.
The each embodiment of table 1 drinks effect research table
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Embodiment 1 44%(22) 54%(27) 2%(1)
Embodiment 2 42%(21) 56%(28) 2%(1)
Embodiment contrast groups A
Comparative example 4,5,6 is added without the nutrition such as new fresh Herba Dendrobii, Fructus Vitis viniferae, Mel, water soluble dietary fiber and Oleum Vitis viniferae and becomes Point, according to the raw material that the Chinese medicine part of embodiment 1,2,3 above is original, preparation for processing is traditional side of boiling Method；The investigation method of using method and using effect is with above.
Table 2 embodiment contrast groups A drinks effect research
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Comparative example 4 36%(18) 40%(20) 24%(12)
Comparative example 5 40%(20) 40%(20) 20%(10)
Comparative example 6 46%(23) 34%(17) 20%(10)
Embodiment contrast groups B
Comparative example 7,8,9 is added without the nutrition such as new fresh Herba Dendrobii, Fructus Vitis viniferae, Mel, water soluble dietary fiber and Oleum Vitis viniferae and becomes Point, according to the raw material that the Chinese medicine part of embodiment 1,2,3 above is original, preparation for processing uses in embodiment 1 The preparation processing method of step E；The investigation method of using method and using effect is with above.
Table 3 embodiment contrast groups B drinks effect research
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Comparative example 7 32%(16) 56%(28) 12%(6)
Comparative example 8 28%(14) 52%(31) 10%(5)
Comparative example 9 36%(18) 52%(26) 12%(6)
Embodiment contrast groups C
The processing method of comparative example 10,11,12 respectively corresponding embodiment 1,2,3 and formula, different be formula in Without Air Bladder pseudosciaenae seu Acipenser composition；The investigation method of using method and using effect is with above.
Table 4 embodiment contrast groups C drinks effect research
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Comparative example 10 44%(22) 46%(23) 10%(5)
Comparative example 11 38%(19) 50%(25) 12%(6)
Comparative example 12 40%(20) 48%(24) 12%(6)
Conclusion:
Contrasted by table 2 and table 1 and can be seen that
The inefficient number of embodiment contrast groups A is about 10 times of embodiment 1,2,3；This shows Chinese crude drug formula of the present invention And between the nutritional labeling such as water soluble dietary fiber and Oleum Vitis viniferae, creating the most collaborative pharmacological action, aqueous soluble dietary is fine Dimension increases effect of the wriggling of the intestines and stomach and promotes the human body absorption to ingredient, it is ensured that metabolic waste normally excretes, additionally The anthocyanidin that contains in Pericarpium Vitis viniferae, resveratrol, have strong anti-oxidation, mutation, alleviate hepatosis, protection cardiovascular etc. Function, strengthens immune system ability；Associate with Chinese medicine and improve assimilation effect and improve the mouthfeel of Chinese medicine, through the essence of the present invention simultaneously The extraction of heart configuration and at utmost ingredient, Chinese crude drug formula of the present invention and preparation method occur in that beat all technology Effect.
Table 2 and table 3 contrast can be seen that
About inefficient number is embodiment contrast groups B 2 times of embodiment contrast groups A, embodiment contrast groups B and traditional Embodiment contrast groups A of boiling method has compared significant raising at therapeutic effect, and this shows that Chinese crude drug of the present invention is through step The preparation processing method of rapid E has had significant raising than traditional boiling method, the extraction degree of active ingredient.
Table 1 is compared with table 4:
The formula of embodiment contrast groups C does not contains Air Bladder pseudosciaenae seu Acipenser, and the invalid number of embodiment contrast groups C is 5 times of left sides of embodiment 1,2,3 Right；And effective percentage number has and has declined；Air Bladder pseudosciaenae seu Acipenser can strengthen gastrointestinal digestive and absorptive functions, improves appetite, is conducive to anti- Control the diseases such as inappetence, anorexia, dyspepsia, abdominal distention, constipation, show Air Bladder pseudosciaenae seu Acipenser serve in formula collaborative and priming return through Effect, Air Bladder pseudosciaenae seu Acipenser application effect achieves unexpected technique effect.
In sum, the medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia that the present invention provides has sour-sweet mouth Sense, have the most again that treatment is the most tired, pyretic toxicity enters blood, heat in blood hinders network simultaneously, yellowish urine, constipation, malaise, gingival hemorrhage, food stagnation Do not disappear, merit that anorexia, middle gas do not save, improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, fall three-hypers, anti- Control diabetes and anti-cancer, the aspect such as anticancer the most powerful.And all raw materials is all from medicine-food two-purpose natural plants, nontoxic secondary make With.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (7)

1. the medicated tea of a clearing away heat and cooling blood treatment thrombocytopenia, it is characterised in that be made up of the raw material of following weight portion: cattle Angle 10-30 part, Radix Rehmanniae 5-15 part, Cortex Moutan 3-9 part, Radix Paeoniae Rubra 5-12 part, Radix Arnebiae (Radix Lithospermi) 3-9 part, Rhizoma Anemarrhenae 3-9 part, Radix Adenophorae (Radix Glehniae) 5-12 part, raw Chinese scholartree Flower 5-10 part, Folium Isatidis 10-30 part, Radix Isatidis 5-10 part, Herba Agrimoniae 10-16 part, Fructus Forsythiae 5-15 part, Caulis Polygoni Multiflori 6-15 part, conjunction Joyous skin 5-10 part, Cacumen Platycladi 5-10 part, Radix Ophiopogonis 5-10 part, Colla Corii Asini 10-15 part, Air Bladder pseudosciaenae seu Acipenser 5-10 part, new fresh Herba Dendrobii 10-20 part, Portugal Grape 10-20 part, Mel, water are appropriate.
The medicated tea of a kind of clearing away heat and cooling blood the most according to claim 1 treatment thrombocytopenia, it is characterised in that by following The raw material of weight portion is made: 20 parts of Cornu Bovis seu Bubali, 10 parts of the Radix Rehmanniae, Cortex Moutan 8 parts, Radix Paeoniae Rubra 10 parts, Radix Arnebiae (Radix Lithospermi) 8 parts, the Rhizoma Anemarrhenae 8 parts, Radix Adenophorae (Radix Glehniae) 8 parts, Flos Sophorae 8 parts, Folium Isatidis 20 parts, Radix Isatidis 8 parts, Herba Agrimoniae 12 parts, Fructus Forsythiae 12 parts, Caulis Polygoni Multiflori 12 parts, Cortex Albiziae 8 parts, Cacumen Platycladi 8 parts of leaf, Radix Ophiopogonis 8 parts, 12 parts of Colla Corii Asini, 8 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
The medicated tea of a kind of clearing away heat and cooling blood the most according to claim 1 treatment thrombocytopenia, it is characterised in that by following The raw material of weight portion is made: 10 parts of Cornu Bovis seu Bubali, 5 parts of the Radix Rehmanniae, Cortex Moutan 3 parts, Radix Paeoniae Rubra 5 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, the Rhizoma Anemarrhenae 3 parts, Radix Adenophorae (Radix Glehniae) 5 parts, life 5 parts of Flos Sophorae, Folium Isatidis 10 parts, Radix Isatidis 5 parts, Herba Agrimoniae 10 parts, Fructus Forsythiae 5 parts, Caulis Polygoni Multiflori 6 parts, Cortex Albiziae 5 parts, Cacumen Platycladi 5 Part, Radix Ophiopogonis 5 parts, 10 parts of Colla Corii Asini, 5 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 10 parts, Fructus Vitis viniferae 10 parts, Mel, water are appropriate.
The medicated tea of a kind of clearing away heat and cooling blood the most according to claim 1 treatment thrombocytopenia, it is characterised in that by following The raw material of weight portion is made: 30 parts of Cornu Bovis seu Bubali, 15 parts of the Radix Rehmanniae, Cortex Moutan 9 parts, Radix Paeoniae Rubra 12 parts, Radix Arnebiae (Radix Lithospermi) 9 parts, the Rhizoma Anemarrhenae 9 parts, Radix Adenophorae (Radix Glehniae) 12 parts, Flos Sophorae 10 parts, Folium Isatidis 30 parts, Radix Isatidis 10 parts, Herba Agrimoniae 16 parts, Fructus Forsythiae 15 parts, Caulis Polygoni Multiflori 15 parts, Cortex Albiziae 10 parts, side Cacumen Platycladi (Cacumen Biotae) 10 parts, Radix Ophiopogonis 10 parts, 15 parts of Colla Corii Asini, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 20 parts, Fructus Vitis viniferae 20 parts, Mel, water are appropriate.
5. the preparation processing method of the medicated tea of a clearing away heat and cooling blood treatment thrombocytopenia, it is characterised in that include following step Suddenly；
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby；
B, fresh for the Herba Dendrobii cleaned up bar is put into microwave oven, keep temperature 50-60 DEG C, carry out heating 10 minutes, then take Go out to put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time The Chinese liquor of 52-60 DEG C, time 10-15min, the rotating speed of juice extractor is 20～30r/s；After standing 10 minutes, add the fresh bar of Herba Dendrobii The distilled water of weight 2-3 times, for the second time juice extractor time 10-15min, juice extractor rotating speed is 80～100r/s, stands 10min； After carry out third time squeeze the juice, add Herba Dendrobii fresh bar weight 3-5 times distilled water, time 20-30min, juice extractor rotating speed be 100～ 150r/s, separates fresh for Herba Dendrobii bar juice with fiber filter, makes the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, cell damage Rate reaches more than 80%, obtains new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber；The warm water that new fresh grape is put into 50-60 DEG C again cleans dry After Jing, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated stand-by；
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 100-150 in tank Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby；
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 5-10 times of weight, stirring is smashed to 100 mesh, at 30-35 Seal at a temperature of DEG C and preserve 24h, sterilizing, filter, put into unglazed hermetically sealed can, obtain Matrix Solution standby；After extracting Matrix Solution It is the cellulase of 0.5-0.7% that Pericarpium Vitis viniferae and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10, Keep 35 DEG C, water soluble dietary fiber can be extracted further after 24h enzymolysis, water soluble dietary fiber is added Matrix Solution Obtain Matrix Solution II；
E, take mix homogeneously after Radix Adenophorae (Radix Glehniae), Caulis Polygoni Multiflori cleaning and sterilizing, respectively with 6 times of weight 85% mol ratio ethanol extractions 2 times, every time 2 hours, merge 2 Radix Adenophorae (Radix Glehniae), Caulis Polygoni Multiflori ethanol extracts, receive alcohol and to be evaporated to relative density at 40 DEG C be 1.15-1.35, Prepare Radix Adenophorae (Radix Glehniae), Caulis Polygoni Multiflori extract standby；
Cornu Bovis seu Bubali, Radix Paeoniae Rubra mix and blend are put into super micron mill, carries out micronizing and obtain the ultra micro mixing of 300-400 mesh carefully Powder；
Take Cortex Moutan, Radix Arnebiae (Radix Lithospermi), the Rhizoma Anemarrhenae, Flos Sophorae, Folium Isatidis, Radix Isatidis, Herba Agrimoniae, Fructus Forsythiae, Cortex Albiziae, Cacumen Platycladi, Radix Ophiopogonis, Ah Glue, Air Bladder pseudosciaenae seu Acipenser, after mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes, put into reach in freezer, at the freezing 10-20 in-10～-20 DEG C Minute, form freezing medicine block, freezing medicine block and ultra micro mixing fine powders boiling extracted 3 times, adds 1-2 times amount water for the first time, Temperature keeps 100-120 DEG C, carries out infusion 10-20 minute；Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, endures Boil 10 minutes；Third time adds 6-10 times amount water, and temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and is concentrated into original The 1/2 of volume, adds Radix Adenophorae (Radix Glehniae), the extract of Caulis Polygoni Multiflori, obtains Matrix Solution III standby；
F, take Matrix Solution I through instantaneous high-temperature 110-130 DEG C, 1-2 minute, put into material-compound tank；Take Matrix Solution II through mesh Number be 100 mesh fine filter filter after put into material-compound tank；Take Matrix Solution III again to put into after the fine filter filter that mesh number is 60 mesh In material-compound tank；
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae；
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, seal through bottle capper and load in vial, Packaged vial puts into temperature 100～120 DEG C, 1.5MP, sterilization in 15～21 minutes steam ovens, packaging, vanning.
The preparation processing method of the medicated tea of a kind of clearing away heat and cooling blood the most according to claim 5 treatment thrombocytopenia, its It is characterised by, step B) in, after new fresh grape cleans up, put into reach in freezer ,-10～-20 DEG C freezing 5-10 minute, make Fructus Vitis viniferae freezes, and after taking out nature defrosting, then carries out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job.
The preparation processing method of the medicated tea of a kind of clearing away heat and cooling blood the most according to claim 5 treatment thrombocytopenia, its Be characterised by, step H) described in material-compound tank endobasal-body solution I, Matrix Solution II, Matrix Solution III, the weight of Oleum Vitis viniferae Proportioning is 10:0.2～0.8:5～10:0.5.
CN201610234285.4A 2016-04-17 2016-04-17 The medicated tea of a kind of clearing away heat and cooling blood treatment thrombocytopenia and preparation processing method Pending CN106166230A (en)

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Citations (1)

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Publication number Priority date Publication date Assignee Title
CN103300450A (en) * 2013-06-14 2013-09-18 浙江大学 Preparation method of raw dendrobium officinale pulp beverage

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Publication number Priority date Publication date Assignee Title
CN103300450A (en) * 2013-06-14 2013-09-18 浙江大学 Preparation method of raw dendrobium officinale pulp beverage

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