CN106234699A - The medicated tea of a kind of heat clearing away Xuanhua treatment heating and preparation processing method - Google Patents

The medicated tea of a kind of heat clearing away Xuanhua treatment heating and preparation processing method Download PDF

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CN106234699A
CN106234699A CN201610234278.4A CN201610234278A CN106234699A CN 106234699 A CN106234699 A CN 106234699A CN 201610234278 A CN201610234278 A CN 201610234278A CN 106234699 A CN106234699 A CN 106234699A
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parts
vitis viniferae
semen
fresh
herba dendrobii
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温从字
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Zhejiang Yu Chen Pharmaceutical Co Ltd
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Zhejiang Yu Chen Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23FCOFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00Tea; Tea substitutes; Preparations thereof
    • A23F3/34Tea substitutes, e.g. matè; Extracts or infusions thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/12Magnesium silicate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/60Fish, e.g. seahorses; Fish eggs
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9064Amomum, e.g. round cardamom
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Abstract

The invention discloses the medicated tea of a kind of heat clearing away Xuanhua treatment heating of the present invention, be made up of the raw material of following weight portion: bean curd 5 15 parts, Radix Puerariae 5 12 parts, 5 10 parts of Folium Mori, 10 16 parts of Semen Armeniacae Amarum, KOUREN 25 parts, Semen Coicis 6 15 parts, Herba Eupatorii 5 10 parts, Radix Scutellariae 5 10 parts, the Rhizoma Anemarrhenae 5 10 parts, 5 10 parts of Radix Glycyrrhizae, Semen oryzae sativae 5 10 parts, Cortex Phellodendri 5 10 parts, Herba Menthae 5 10 parts, Rhizoma Imperatae 5 10 parts, 13 parts of Rhizoma Zingiberis Recens, 10 15 parts of Talcum.The invention have the advantage that inventive formulation leads clearly heat, strengthening vital QI to eliminate pathogenic factors, treatment heating off, improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.

Description

The medicated tea of a kind of heat clearing away Xuanhua treatment heating and preparation processing method
Technical field
The present invention relates to the medicated tea of a kind of heat clearing away Xuanhua treatment heating, in particular, relate to a kind of heat clearing away Xuanhua and control The herb tea formula treating heating and preparation method thereof technical field.
Background technology
The symptom of heating performance is: forehead is boiling hot, have a dizzy spell, and general malaise, hypohidrosis xerostomia, mechanism of qi close strongly fragrant, time serious Not only ache all over the body, even burns confusion, twitches, sometimes also has the coldest sensation, fatigue and weak, muscular soreness, skin The phenomenons such as skin is pale, fear of cold or shiver with cold.
The most traditional beverage, only focuses on mouthfeel, is of low nutritive value, do not have lead off clearly heat, strengthening vital QI to eliminate pathogenic factors, treatment heating, carry High body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, drop three-hypers, prevent and treat diabetes and anti-cancer, the merit of the aspect such as anticancer Can, it is impossible to releasing the sufferings of client, and traditional herbal tea is by Traditional medicine infusion, flavour of a drug weight mouthfeel is poor, it is impossible to preserve for a long time.At present Not yet occur a kind of in good taste on market, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen the beverage of body immunity simultaneously.
Summary of the invention
The present invention is directed to the deficiency of existing product, and provide a kind of fresh juice beverage to regulate the effect of human physiological functions, This beverage have be easily absorbed by the human body, medicinal function is notable, delicious flavour, good mouthfeel, improve self and increase the wriggling of the intestines and stomach, Cure the disease and strengthen the medicated tea that a kind of heat clearing away Xuanhua treatment of the advantages such as body immunity is generated heat simultaneously.
The medicated tea of a kind of heat clearing away Xuanhua treatment heating, is made up of the raw material of following weight portion: bean curd 5-15 part, Radix Puerariae 5-12 Part, Folium Mori 5-10 part, Semen Armeniacae Amarum 10-16 part, KOUREN 2-5 part, Semen Coicis 6-15 part, Herba Eupatorii 5-10 part, Radix Scutellariae 5-10 part, Rhizoma Anemarrhenae 5-10 Part, Radix Glycyrrhizae 5-10 part, Semen oryzae sativae 5-10 part, Cortex Phellodendri 5-10 part, Herba Menthae 5-10 part, Rhizoma Imperatae 5-10 part, Rhizoma Zingiberis Recens 1-3 part, Talcum 10- 15 parts, Air Bladder pseudosciaenae seu Acipenser 5-10 part, new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae 10-20 part, Mel, water appropriate.
The preparation processing method of the medicated tea of described a kind of heat clearing away Xuanhua treatment heating, comprises the following steps;
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby;
B, fresh for the Herba Dendrobii cleaned up bar is put into microwave oven, keep temperature 50-60 DEG C, carry out heating 10 minutes, then take Go out to put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time The Chinese liquor of 52-60 DEG C, time 10-15min, the rotating speed of juice extractor is 20~30r/s;After standing 10 minutes, add the fresh bar of Herba Dendrobii The distilled water of weight 2-3 times, for the second time juice extractor time 10-15min, juice extractor rotating speed is 80~100r/s, stands 10min; After carry out third time squeeze the juice, add Herba Dendrobii fresh bar weight 3-5 times distilled water, time 20-30min, juice extractor rotating speed be 100~ 150r/s, separates fresh for Herba Dendrobii bar juice with fiber filter, makes the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, cell damage Rate reaches more than 80%, obtains new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber;The warm water that new fresh grape is put into 50-60 DEG C again cleans dry After Jing, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated stand-by;
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 100-150 in tank Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby;
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 5-10 times of weight, stirring is smashed to 100 mesh, at 30-35 Seal at a temperature of DEG C and preserve 24h, sterilizing, filter, put into unglazed hermetically sealed can, obtain Matrix Solution standby;After extracting Matrix Solution It is the cellulase of 0.5-0.7% that Pericarpium Vitis viniferae and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10, Keep 35 DEG C, water soluble dietary fiber can be extracted further after 24h enzymolysis, water soluble dietary fiber is added Matrix Solution Obtain Matrix Solution II;
E, take mix homogeneously after Radix Puerariae, Semen Armeniacae Amarum, KOUREN and Semen Coicis cleaning and sterilizing, carry with 6 times of weight 85% mol ratio ethanol respectively Taking 2 times, each 2 hours, merge 2 Radix Puerariaes, Semen Armeniacae Amarum, KOUREN and Semen Coicis ethanol extract, stand precipitate with ethanol, filter, filtrate concentrates To without alcohol taste, and to be evaporated to relative density at 40 DEG C be 1.15-1.35, prepared Radix Puerariae, Semen Armeniacae Amarum, KOUREN and the extraction of Semen Coicis Thing is standby;
Herba Menthae, Folium Mori, Talcum mix and blend are put into super micron mill, and super micron mill heating keeps temperature 80 degree 5-6 minute, Carry out micronizing and obtain the ultra micro mixing fine powders of 300-400 mesh;Enter relative to ultra micro mixing fine powders quality 6~the distillation of 8 times Water, first soaks 10min~15min, pours in volatile oil extractor, and the way of distillation extracts volatile oil 2~4h, it is thus achieved that volatile oil is with super Microring array fine powder medicinal residues;
Taking bean curd, Herba Eupatorii, Radix Scutellariae, the Rhizoma Anemarrhenae, Radix Glycyrrhizae, Semen oryzae sativae, Cortex Phellodendri, Herba Menthae, Rhizoma Imperatae, Rhizoma Zingiberis Recens, Air Bladder pseudosciaenae seu Acipenser, mix homogeneously adds 30- 60 DEG C of warm water soaking, after 10 minutes, put into reach in freezer ,-10~-20 DEG C freezing 10-20 minute, form freezing medicine block, by cold Freezing medicine block and ultra micro mixing fine powders medicinal residues boiling is extracted 3 times, add 1-2 times amount water for the first time, temperature keeps 100-120 DEG C, Carry out infusion 10-20 minute;Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes;Third time adds 6-10 times amount water, temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and is concentrated into the 1/2 of original volume, adds Pueraria lobota The extract of root, Semen Armeniacae Amarum, KOUREN and Semen Coicis and volatile oil, obtain Matrix Solution III standby;
F, take Matrix Solution I through instantaneous high-temperature 110-130 DEG C, 1-2 minute, put into material-compound tank;Take Matrix Solution II through mesh Number be 100 mesh fine filter filter after put into material-compound tank;Take Matrix Solution III again to put into after the fine filter filter that mesh number is 60 mesh In material-compound tank;
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae;
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, seal through bottle capper and load in vial, Packaged vial puts into temperature 100~120 DEG C, 1.5MP, sterilization in 15~21 minutes steam ovens, packaging, vanning.
Further: step B) in, after new fresh grape cleans up, put into reach in freezer ,-10~-20 DEG C freezing 5-10 minute, Make Fructus Vitis viniferae freeze, after taking out nature defrosting, then carry out Fructus Vitis viniferae meat and Pericarpium Vitis viniferae detached job.
Further: step H) described in material-compound tank endobasal-body solution I, Matrix Solution II, Matrix Solution III, Oleum Vitis viniferae Weight proportion be 10:0.2~0.8:5~10:0.5.
Bean curd, enters spleen, stomach warp, and expelling pathogenic factors from the exterior induces sweat, eliminating damp-heat.
Radix Puerariae, sweet, pungent, cool.There are expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the merit of yang invigorating antidiarrheal.
Folium Mori, dispelling wind and heat pathogens, lung heat clearing, improving eyesight.Main anemopyretic cold;Pathogenic wind-warm from the beginning of, fever and headache, perspiration and aversion to wind, breast of coughing Bitterly;Or dryness of the lung dry cough without phlegm.
Semen Armeniacae Amarum, bitter, tepor, relieving cough and asthma, loosening bowel to relieve constipation, return lung meridian, wind and cold is violated to the cough with asthma card of lung.
KOUREN, cures mainly the stomachache disease such as abdominal distention, eructation regurgitation.
Semen Coicis, spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.
Herba Eupatorii, appetizing of being amusing, deliver expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer Table disease, feeling of fullness in the head is uncomfortable in chest.
Radix Scutellariae, has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.
The Rhizoma Anemarrhenae, returns lung, stomach, kidney channel.Clearing away heat-fire is nourshing Yin and drynsessmoistening prescription.Calentura excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat disappears Yearningly, dryness of the intestine constipation.
Radix Glycyrrhizae, and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.
Semen oryzae sativae, the crude fibre molecule of Testa oryzae layer, help gastrointestinal peristalsis, to curative effects such as gastropathy, constipation, hemorrhoid.
Cortex Phellodendri, bitter, cold.Return kidney, bladder warp.Heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, Leukorrhagia, pyretic stranguria, tinea pedis, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
Herba Menthae, removing toxic substances relieves inflammation or internal heat, antisepsis and sterilization, diuresis, reduce phlegm, stomach invigorating and the effect such as aid digestion.
Rhizoma Imperatae, returns lung, stomach, bladder warp.Cooling blood for hemostasis, clearing away heat and promoting diuresis.
Rhizoma Zingiberis Recens, seasoning, warming middle-JIAO, also there are fabulous sterilization, antiinflammatory, expelling summer-heat, detoxifying effect.
Talcum, clearing away fire and eliminating phlegm, dampness removing is relieved summer heat, and restores menstrual flow and invigorates blood circulation, and antidiarrheal dysentery is vomitted, consumer edema fire-toxin.
Fructus Vitis viniferae is the most delicious and tasty, and nutritive value is the highest, containing mineral calcium, potassium, phosphorus, ferrum and multiple in Fructus Vitis viniferae Vitamin B1, vitamin B2, vitamin B6, vitamin C and Citrin etc., possibly together with the aminoacid of multiple needed by human body, multiple Fruit acid contributes to digestion, suitably eats a little Fructus Vitis viniferae more, can be good for Pi stomach function regulating, and to neurasthenia, overfatigue is of great advantage and has.
The natural tradition medicinal and edible Chinese medicine above with multiple health care is share, leads clearly heat, strengthening vital QI to eliminate pathogenic factors off, control Treat heating, improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.Each by great many of experiments screening The proportioning of component, scientific and reasonable;And whole preparation technology is rationally and extract drugs rate efficiency is high, can retain in raw material well Effective ingredient, do not bring any impurity, and sweet mouthfeel into, have no side effect.
The invention has the beneficial effects as follows:
1, the formula of the present invention, has promoting the production of body fluid to quench thirst, gastric acid secretion, helps digest, and health body-building has calm nerves and declines Weak, lessen fatigue, containing various trace elements such as calcium, ferrum, zinc, selenium, sodium etc., raising body immunity, defying age, toxin expelling are supported Face, nourish taste, three-hypers drops, to prevent and treat diabetes and anti-cancer, the aspect such as anticancer the most powerful, regulates human physiological functions.
2, the present invention is rich in anthocyanidin, it is possible to protection human body is from the damage of free radical, it is possible to strengthens blood vessel elasticity, relax Blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect;Immune system ability can be strengthened, there is strong anti-oxidation, resist Suddenly change, alleviate the function such as hepatosis, protection cardiovascular;
3, add the Chinese herbal medicine such as bean curd, Herba Eupatorii, Radix Scutellariae, the Rhizoma Anemarrhenae, Radix Glycyrrhizae, Semen oryzae sativae, Cortex Phellodendri, Herba Menthae, Rhizoma Imperatae, Rhizoma Zingiberis Recens and there is clear a surname Expel the heat-evil, strengthening vital QI to eliminate pathogenic factors, treatment heating, improve the function such as body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, resisting fatigue.
4, the products taste that the production technology of the present invention and preparation method draw is sour-sweet tasty and refreshing, rich in dendrobium polysaccharide, has The highest health care and medical value, long-term drink can with YIN nourishing skin care, change skin colour, defying age, life lengthening, and Carrying and drink conveniently, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen the beverage of body immunity simultaneously, the shelf-life is up to 1- 2 years.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about The present invention, but and it is not so limited the present invention.
Embodiment 1
The medicated tea of a kind of heat clearing away Xuanhua treatment heating, is made up of the raw material of following weight portion: bean curd 8 parts, Radix Puerariae 10 parts, Folium Mori 8 Part, 12 parts of Semen Armeniacae Amarum, KOUREN 2 parts, Semen Coicis 8 parts, Herba Eupatorii 8 parts, Radix Scutellariae 8 parts, the Rhizoma Anemarrhenae 8 parts, 8 parts of Radix Glycyrrhizae, Semen oryzae sativae 8 parts, Cortex Phellodendri 8 parts, Herba Menthae 8 parts, Rhizoma Imperatae 8 parts, 2 parts of Rhizoma Zingiberis Recens, 12 parts of Talcum, 8 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
The preparation processing method of the medicated tea of a kind of heat clearing away Xuanhua treatment heating, described preparation method comprises the following steps;
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby;
Fresh for the Herba Dendrobii cleaned up bar is put into microwave oven by B, keeps temperature 50-60 DEG C, carries out heating 10 minutes, further take out Put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content 52 of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time DEG C Chinese liquor, time 15min, the rotating speed of juice extractor is 30r/s;After standing 10 minutes, add the steaming of Herba Dendrobii fresh bar weight 2.5 times Distilled water, for the second time juice extractor time 15min, juice extractor rotating speed is 80r/s, stands 10min;After carry out third time squeeze the juice, add The distilled water of Herba Dendrobii fresh bar weight 3-5 times, time 30min, juice extractor rotating speed is 150r/s, by fresh for Herba Dendrobii bar juice and fiber mistake Filter separate, make the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, broken cell rate reaches more than 80%, obtain new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber;Again new fresh grape is put into after the warm water of 55 DEG C cleans up, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated Stand-by;After new fresh grape cleans up, put into reach in freezer ,-10 ~-20 DEG C of freezings 10 minutes, make Fructus Vitis viniferae freeze, take out certainly After so thawing, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job.
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 120 in tank Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby;
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 6 times of weight, stirring is smashed to 100 mesh, 30-35 DEG C of temperature Degree lower seal preserves 24h, sterilizing, filters, puts into unglazed hermetically sealed can, obtain Matrix Solution standby;Extract the Fructus Vitis viniferae after Matrix Solution It is the cellulase of 0.5-0.7% that skin and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10, keeps 35 DEG C, water soluble dietary fiber can be extracted after 24h enzymolysis further, water soluble dietary fiber is added Matrix Solution and obtains Matrix Solution II;Rich in anthocyanidin in Pericarpium Vitis viniferae, it is possible to protection human body is from the damage of free radical, it is possible to enhancing blood vessel elasticity, Lax blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect;Immune system ability can be strengthened, there is strong antioxygen Change, mutation, alleviate hepatosis, protection function, Pericarpium Vitis viniferae and the Herba Dendrobii fresh bar fiber such as cardiovascular together with stir smash through Anthocyanidin mentioned by hydromel, can protect the quality of anthocyanidin while farthest extracting anthocyanidin.By water solublity meals Food fiber adds Matrix Solution and obtains Matrix Solution II, can increase effect of the wriggling of the intestines and stomach, it is ensured that metabolic waste is normally discharged External;Adsorbing various metabolic waste, be allowed to normally excrete, the comprehensive utilization value improving Herba Dendrobii improves human body centering simultaneously The absorption of medicine composition.
E, take mix homogeneously after Radix Puerariae, Semen Armeniacae Amarum, KOUREN and Semen Coicis cleaning and sterilizing, respectively with 6 times of weight 85% mol ratio second Alcohol extraction 2 times, each 2 hours, merges 2 Radix Puerariaes, Semen Armeniacae Amarum, KOUREN and Semen Coicis ethanol extract, stands precipitate with ethanol, filter, filtrate It is concentrated into without alcohol taste, and to be evaporated to relative density at 40 DEG C be 1.15-1.35, prepare Radix Puerariae, Semen Armeniacae Amarum, KOUREN and Semen Coicis Extract is standby;
Herba Menthae, Folium Mori, Talcum mix and blend are put into super micron mill, and super micron mill heating keeps temperature 80 degree 5-6 minute, Carry out micronizing and obtain the ultra micro mixing fine powders of 300-400 mesh;Enter relative to ultra micro mixing fine powders quality 6~the distillation of 8 times Water, first soaks 10min~15min, pours in volatile oil extractor, and the way of distillation extracts volatile oil 2~4h, it is thus achieved that volatile oil is with super Microring array fine powder medicinal residues;
Taking bean curd, Herba Eupatorii, Radix Scutellariae, the Rhizoma Anemarrhenae, Radix Glycyrrhizae, Semen oryzae sativae, Cortex Phellodendri, Herba Menthae, Rhizoma Imperatae, Rhizoma Zingiberis Recens, Air Bladder pseudosciaenae seu Acipenser, mix homogeneously adds 30- 60 DEG C of warm water soaking, after 10 minutes, put into reach in freezer ,-10~-20 DEG C freezing 10-20 minute, form freezing medicine block, by cold Freezing medicine block and ultra micro mixing fine powders medicinal residues boiling is extracted 3 times, add 1-2 times amount water for the first time, temperature keeps 100-120 DEG C, Carry out infusion 10-20 minute;Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes;Third time adds 6-10 times amount water, temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and is concentrated into the 1/2 of original volume, adds Pueraria lobota The extract of root, Semen Armeniacae Amarum, KOUREN and Semen Coicis and volatile oil, obtain Matrix Solution III standby;
F, take Matrix Solution I through instantaneous high-temperature 120 DEG C, 1-2 minute, put into material-compound tank;Taking Matrix Solution II through mesh number is Material-compound tank is put into after the fine filter filter of 100 mesh;Take Matrix Solution III again and put into dispensing after the fine filter filter that mesh number is 60 mesh In tank;
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae;Supercritical extraction can be Extract under room temperature 37 DEG C and CO2 gas blanket, effectively prevent oxidation and the loss of heat-sensitive substance.Therefore, The effective ingredient of medicinal plants is remain in extract, and can be high boiling point, low volatility, the easy material being pyrolyzed the lowest Extract under its boiling temperature;
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, and described material-compound tank endobasal-body solution I, matrix are molten Liquid II, Matrix Solution III, the weight proportion of Oleum Vitis viniferae are 10:0.5:6:0.5.Sealing through bottle capper loads in vial, Packaged vial puts into temperature 100~120 DEG C, 1.5MP, sterilization in 15~21 minutes steam ovens, packaging, vanning, Carrying and drink conveniently, the shelf-life is up to 1-2.
Embodiment 2
The medicated tea of a kind of heat clearing away Xuanhua treatment heating, is made up of the raw material of following weight portion: bean curd 5 parts, Radix Puerariae 5 parts, Folium Mori 5 Part, 10 parts of Semen Armeniacae Amarum, KOUREN 2 parts, Semen Coicis 6 parts, Herba Eupatorii 5 parts, Radix Scutellariae 5 parts, the Rhizoma Anemarrhenae 5 parts, 5 parts of Radix Glycyrrhizae, Semen oryzae sativae 5 parts, Cortex Phellodendri 5 parts, Herba Menthae 5 parts, Rhizoma Imperatae 5 parts, 1 part of Rhizoma Zingiberis Recens, 10 parts of Talcum, 5 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 10 parts, Fructus Vitis viniferae 10 parts, Mel, water are appropriate. Processing method is with embodiment 1.
Embodiment 3
The medicated tea of a kind of heat clearing away Xuanhua treatment heating, is made up of the raw material of following weight portion: bean curd 15 parts, Radix Puerariae 12 parts, Folium Mori 10 parts, 16 parts of Semen Armeniacae Amarum, KOUREN 5 parts, Semen Coicis 15 parts, Herba Eupatorii 10 parts, Radix Scutellariae 10 parts, the Rhizoma Anemarrhenae 10 parts, 10 parts of Radix Glycyrrhizae, Semen oryzae sativae 10 parts, Cortex Phellodendri 10 parts, Herba Menthae 10 parts, Rhizoma Imperatae 10 parts, 3 parts of Rhizoma Zingiberis Recens, 15 parts of Talcum, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 20 parts, Fructus Vitis viniferae 20 parts, Mel, water are appropriate.Processing method is with embodiment 1.
Clinical experiment divides three parts:
(1) animal acute toxicity and chronic toxicity experiment:
1, animal acute toxicity test
Medicine: the embodiment of the present invention 1, embodiment 2 and embodiment 3 medicated tea add the medicated tea powder paste that rice flour is made.
Experimental animal: regular grade NIH mice, body weight 18g ± 2g, male and female half and half.
Method and result:
By three kinds of each 50g of medicated tea, add rice flour.Experiment mice is randomly divided into three groups of male and female half and half, respectively three kinds of medicated tea of feeding Powder is stuck with paste, volume 1ml/10g body weight, and close observation 8 hours is also noted down, and continues to observe 7 days;In 7 days, mice is without death, OK For vivaciously, food ration is as usual, and hair color light is without loose dirt, without fainting from fear addicted to saliva, and eye, mouth, nose, ear and crissum secretions without exception, Without the rotten toe that docks.5 execution of selection from three groups respectively, finding of naked eye: the important organs such as the heart, liver, lung, gastric and thymus, not See abnormal change, show that two kinds of these nutritive powders are all without acute toxicity.
2, long-term toxicity test for animals
Medicine: the embodiment of the present invention 1, embodiment 2 and embodiment 3 gained medicated tea add the medicated tea powder paste that rice flour is made.
Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.
Method and result:
The configuration that two kinds of medicated tea powder are stuck with paste: be divided into high, medium and low three dosage groups, respectively the 200 of edible for patients amount, 100, 50g;Experimental mouse is randomly divided into two groups, and the medicated tea powder that feeding modulates continuously respectively is stuck with paste, and continuous feeding 40 days observes animal General toxic reaction and the order of severity, place after death by rule of operation check each position, and carry out hematology, ALT, BUN and the heart, The pathological examination of the main organs such as liver, spleen, lung, kidney, stomach;
Through long-term feeding, all there is not toxic reaction in two groups of rats.Growth promoter is good.Macroscopic appearance and main organs have no Abnormal.Peripheral hemogram and Serum ALT, BUN compare with matched group without pathologic change.The pathological replacement heart, liver, spleen, lung, kidney, stomach Deng the most significant change, it is understood that through proved by pathology, two kinds of medicated tea powder are stuck with paste and showed animal without chronic toxicity.
By two above toxicity test, it was demonstrated that the medicated tea that the present invention is made by embodiment 1, embodiment 2 and embodiment 3 is Safety, have no side effect, can be used to clinical patients is carried out clinical trial.
3, the embodiment of the present invention drinks effect research:
(1) investigation method:
1. crowd is drunk: general population
2. Ganderwa: 7 days
3. number is drunk: 50 people
4. drinking method: 800mL for each person every day
5. index: after drinking substantially general malaise, hypohidrosis xerostomia, mechanism of qi close strongly fragrant, dysphoria, lean body mass, tired mind, The transference cures such as inappetence, and mouthfeel is the most sour-sweet for effective;Drink rear general malaise, hypohidrosis xerostomia, mechanism of qi close strongly fragrant, irritated not The remissions such as peace, lean body mass, tired mind, inappetence, and mouthfeel is the most sour-sweet, is designated as effectively.Without substantially relaxing after drinking It is invalid that suitable sense is then designated as.
(2) survey result
Survey result is shown in Table 1.Be test result indicate that by table 1, embodiment 1,2,3 has the respondent of 98% to feel that the present invention is carried The beverage mouthfeel of confession is the most sour-sweet, and above-mentioned clinical symptom disappearance or be eased, the respondent of only 2% drink after without substantially Increase comfort.
The each embodiment of table 1 drinks effect research table
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Embodiment 1 44%(22) 54%(27) 2%(1)
Embodiment 2 42%(21) 56%(28) 2%(1)
Embodiment 3 42%(21) 56%(28) 2%(1)
Embodiment contrast groups A
Comparative example 4,5,6 is added without the nutrition such as new fresh Herba Dendrobii, Fructus Vitis viniferae, Mel, water soluble dietary fiber and Oleum Vitis viniferae and becomes Point, according to the raw material that the Chinese medicine part of embodiment 1,2,3 above is original, preparation for processing is traditional side of boiling Method;The investigation method of using method and using effect is with above.
Table 2 embodiment contrast groups A drinks effect research
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Comparative example 4 36%(18) 40%(20) 24%(12)
Comparative example 5 40%(20) 40%(20) 20%(10)
Comparative example 6 46%(23) 34%(17) 20%(10)
Embodiment contrast groups B
Comparative example 7,8,9 is added without the nutrition such as new fresh Herba Dendrobii, Fructus Vitis viniferae, Mel, water soluble dietary fiber and Oleum Vitis viniferae and becomes Point, according to the raw material that the Chinese medicine part of embodiment 1,2,3 above is original, preparation for processing uses in embodiment 1 The preparation processing method of step E;The investigation method of using method and using effect is with above.
Table 3 embodiment contrast groups B drinks effect research
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Comparative example 7 32%(16) 56%(28) 12%(6)
Comparative example 8 28%(14) 52%(31) 10%(5)
Comparative example 9 36%(18) 52%(26) 12%(6)
Embodiment contrast groups C
The processing method of comparative example 10,11,12 respectively corresponding embodiment 1,2,3 and formula, different be formula in Without Air Bladder pseudosciaenae seu Acipenser composition;The investigation method of using method and using effect is with above.
Table 4 embodiment contrast groups C drinks effect research
Group/effect Obvious effective rate (number) Effective percentage (number) Inefficiency (number)
Comparative example 10 44%(22) 46%(23) 10%(5)
Comparative example 11 38%(19) 50%(25) 12%(6)
Comparative example 12 40%(20) 48%(24) 12%(6)
Conclusion:
Contrasted by table 2 and table 1 and can be seen that
The inefficient number of embodiment contrast groups A is about 10 times of embodiment 1,2,3;This shows Chinese crude drug formula of the present invention And between the nutritional labeling such as water soluble dietary fiber and Oleum Vitis viniferae, creating the most collaborative pharmacological action, aqueous soluble dietary is fine Dimension increases effect of the wriggling of the intestines and stomach and promotes the human body absorption to ingredient, it is ensured that metabolic waste normally excretes, additionally The anthocyanidin that contains in Pericarpium Vitis viniferae, resveratrol, have strong anti-oxidation, mutation, alleviate hepatosis, protection cardiovascular etc. Function, strengthens immune system ability;Associate with Chinese medicine and improve assimilation effect and improve the mouthfeel of Chinese medicine, through the essence of the present invention simultaneously The extraction of heart configuration and at utmost ingredient, Chinese crude drug formula of the present invention and preparation method occur in that beat all technology Effect.
Table 2 and table 3 contrast can be seen that
About inefficient number is embodiment contrast groups B 2 times of embodiment contrast groups A, embodiment contrast groups B and traditional Embodiment contrast groups A of boiling method has compared significant raising at therapeutic effect, and this shows that Chinese crude drug of the present invention is through step The preparation processing method of rapid E has had significant raising than traditional boiling method, the extraction degree of active ingredient.
Table 1 is compared with table 4:
The formula of embodiment contrast groups C does not contains Air Bladder pseudosciaenae seu Acipenser, and the invalid number of embodiment contrast groups C is 5 times of left sides of embodiment 1,2,3 Right;And effective percentage number has and has declined;Show Air Bladder pseudosciaenae seu Acipenser serve in formula collaborative and priming return through effect, Air Bladder pseudosciaenae seu Acipenser should Unexpected technique effect is achieved by effect.
In sum, the medicated tea of a kind of heat clearing away Xuanhua treatment heating that the present invention provides, lead clearly heat, strengthening vital QI to eliminate pathogenic factors off, control Treat heating, there is sour-sweet mouthfeel, improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, fall three-hypers, preventing and treating glycosuria Sick and anti-cancer, the aspect such as anticancer are the most powerful.And all raw materials is all from medicine-food two-purpose natural plants, have no side effect.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (7)

1. the medicated tea of heat clearing away Xuanhua treatment heating, it is characterised in that be made up of the raw material of following weight portion: bean curd 5-15 Part, Radix Puerariae 5-12 part, Folium Mori 5-10 part, Semen Armeniacae Amarum 10-16 part, KOUREN 2-5 part, Semen Coicis 6-15 part, Herba Eupatorii 5-10 part, Radix Scutellariae 5-10 Part, Rhizoma Anemarrhenae 5-10 part, Radix Glycyrrhizae 5-10 part, Semen oryzae sativae 5-10 part, Cortex Phellodendri 5-10 part, Herba Menthae 5-10 part, Rhizoma Imperatae 5-10 part, Rhizoma Zingiberis Recens 1- 3 parts, Talcum 10-15 part, Air Bladder pseudosciaenae seu Acipenser 5-10 part, new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae 10-20 part, Mel, water appropriate.
The medicated tea of a kind of heat clearing away Xuanhua the most according to claim 1 treatment heating, it is characterised in that by following weight portion Raw material is made: bean curd 8 parts, Radix Puerariae 10 parts, 8 parts of Folium Mori, 12 parts of Semen Armeniacae Amarum, KOUREN 2 parts, Semen Coicis 8 parts, Herba Eupatorii 8 parts, Radix Scutellariae 8 parts, know Female 8 parts, 8 parts of Radix Glycyrrhizae, Semen oryzae sativae 8 parts, Cortex Phellodendri 8 parts, Herba Menthae 8 parts, Rhizoma Imperatae 8 parts, 2 parts of Rhizoma Zingiberis Recens, 12 parts of Talcum, 8 parts of Air Bladder pseudosciaenae seu Acipenser, fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
The medicated tea of a kind of heat clearing away Xuanhua the most according to claim 1 treatment heating, it is characterised in that by following weight portion Raw material is made: bean curd 5 parts, Radix Puerariae 5 parts, 5 parts of Folium Mori, 10 parts of Semen Armeniacae Amarum, KOUREN 2 parts, Semen Coicis 6 parts, Herba Eupatorii 5 parts, Radix Scutellariae 5 parts, know Female 5 parts, 5 parts of Radix Glycyrrhizae, Semen oryzae sativae 5 parts, Cortex Phellodendri 5 parts, Herba Menthae 5 parts, Rhizoma Imperatae 5 parts, 1 part of Rhizoma Zingiberis Recens, 10 parts of Talcum, 5 parts of Air Bladder pseudosciaenae seu Acipenser, fresh Herba Dendrobii 10 parts, Fructus Vitis viniferae 10 parts, Mel, water are appropriate.
The medicated tea of a kind of heat clearing away Xuanhua the most according to claim 1 treatment heating, it is characterised in that by following weight portion Raw material is made: bean curd 15 parts, Radix Puerariae 12 parts, 10 parts of Folium Mori, 16 parts of Semen Armeniacae Amarum, KOUREN 5 parts, Semen Coicis 15 parts, Herba Eupatorii 10 parts, Radix Scutellariae 10 Part, the Rhizoma Anemarrhenae 10 parts, 10 parts of Radix Glycyrrhizae, Semen oryzae sativae 10 parts, Cortex Phellodendri 10 parts, Herba Menthae 10 parts, Rhizoma Imperatae 10 parts, 3 parts of Rhizoma Zingiberis Recens, 15 parts of Talcum, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 20 parts, Fructus Vitis viniferae 20 parts, Mel, water are appropriate.
5. the preparation processing method of the medicated tea of heat clearing away Xuanhua treatment heating, it is characterised in that comprise the following steps;
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby;
B, fresh for the Herba Dendrobii cleaned up bar is put into microwave oven, keep temperature 50-60 DEG C, carry out heating 10 minutes, then take Go out to put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time The Chinese liquor of 52-60 DEG C, time 10-15min, the rotating speed of juice extractor is 20~30r/s;After standing 10 minutes, add the fresh bar of Herba Dendrobii The distilled water of weight 2-3 times, for the second time juice extractor time 10-15min, juice extractor rotating speed is 80~100r/s, stands 10min; After carry out third time squeeze the juice, add Herba Dendrobii fresh bar weight 3-5 times distilled water, time 20-30min, juice extractor rotating speed be 100~ 150r/s, separates fresh for Herba Dendrobii bar juice with fiber filter, makes the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, cell damage Rate reaches more than 80%, obtains new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber;The warm water that new fresh grape is put into 50-60 DEG C again cleans dry After Jing, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated stand-by;
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 100-150 in tank Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby;
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 5-10 times of weight, stirring is smashed to 100 mesh, at 30-35 Seal at a temperature of DEG C and preserve 24h, sterilizing, filter, put into unglazed hermetically sealed can, obtain Matrix Solution standby;After extracting Matrix Solution It is the cellulase of 0.5-0.7% that Pericarpium Vitis viniferae and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10, Keep 35 DEG C, water soluble dietary fiber can be extracted further after 24h enzymolysis, water soluble dietary fiber is added Matrix Solution Obtain Matrix Solution II;
E, take mix homogeneously after Radix Puerariae, Semen Armeniacae Amarum, KOUREN and Semen Coicis cleaning and sterilizing, carry with 6 times of weight 85% mol ratio ethanol respectively Taking 2 times, each 2 hours, merge 2 Radix Puerariaes, Semen Armeniacae Amarum, KOUREN and Semen Coicis ethanol extract, stand precipitate with ethanol, filter, filtrate concentrates To without alcohol taste, and to be evaporated to relative density at 40 DEG C be 1.15-1.35, prepared Radix Puerariae, Semen Armeniacae Amarum, KOUREN and the extraction of Semen Coicis Thing is standby;
Herba Menthae, Folium Mori, Talcum mix and blend are put into super micron mill, and super micron mill heating keeps temperature 80 degree 5-6 minute, Carry out micronizing and obtain the ultra micro mixing fine powders of 300-400 mesh;Enter relative to ultra micro mixing fine powders quality 6~the distillation of 8 times Water, first soaks 10min~15min, pours in volatile oil extractor, and the way of distillation extracts volatile oil 2~4h, it is thus achieved that volatile oil is with super Microring array fine powder medicinal residues;
Taking bean curd, Herba Eupatorii, Radix Scutellariae, the Rhizoma Anemarrhenae, Radix Glycyrrhizae, Semen oryzae sativae, Cortex Phellodendri, Herba Menthae, Rhizoma Imperatae, Rhizoma Zingiberis Recens, Air Bladder pseudosciaenae seu Acipenser, mix homogeneously adds 30- 60 DEG C of warm water soaking, after 10 minutes, put into reach in freezer ,-10~-20 DEG C freezing 10-20 minute, form freezing medicine block, by cold Freezing medicine block and ultra micro mixing fine powders medicinal residues boiling is extracted 3 times, add 1-2 times amount water for the first time, temperature keeps 100-120 DEG C, Carry out infusion 10-20 minute;Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes;Third time adds 6-10 times amount water, temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and is concentrated into the 1/2 of original volume, adds Pueraria lobota The extract of root, Semen Armeniacae Amarum, KOUREN and Semen Coicis and volatile oil, obtain Matrix Solution III standby;
F, take Matrix Solution I through instantaneous high-temperature 110-130 DEG C, 1-2 minute, put into material-compound tank;Take Matrix Solution II through mesh Number be 100 mesh fine filter filter after put into material-compound tank;Take Matrix Solution III again to put into after the fine filter filter that mesh number is 60 mesh In material-compound tank;
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is: Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae;
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, seal through bottle capper and load in vial, Packaged vial puts into temperature 100~120 DEG C, 1.5MP, sterilization in 15~21 minutes steam ovens, packaging, vanning.
The preparation processing method of the medicated tea of a kind of heat clearing away Xuanhua the most according to claim 5 treatment heating, it is characterised in that Step B) in, after new fresh grape cleans up, put into reach in freezer ,-10~-20 DEG C freezing 5-10 minute, make Fructus Vitis viniferae freeze, After taking out nature defrosting, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job.
The preparation processing method of the medicated tea of a kind of heat clearing away Xuanhua the most according to claim 5 treatment heating, it is characterised in that Step H) described in material-compound tank endobasal-body solution I, Matrix Solution II, Matrix Solution III, the weight proportion of Oleum Vitis viniferae be 10: 0.2~0.8:5~10:0.5.
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CN106620401A (en) * 2017-03-13 2017-05-10 李耀宗 Medicament for treating fever and preparation method thereof
CN108853304A (en) * 2018-08-20 2018-11-23 陕西必康制药集团控股有限公司 Clearing heat and detoxicating particle and preparation method thereof

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Application publication date: 20161221