CN106177488A - The medicated tea of a kind of benefiting qi and nourishing blood treatment aplastic anemia disease and preparation processing method - Google Patents
The medicated tea of a kind of benefiting qi and nourishing blood treatment aplastic anemia disease and preparation processing method Download PDFInfo
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- CN106177488A CN106177488A CN201610234344.8A CN201610234344A CN106177488A CN 106177488 A CN106177488 A CN 106177488A CN 201610234344 A CN201610234344 A CN 201610234344A CN 106177488 A CN106177488 A CN 106177488A
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- parts
- radix
- vitis viniferae
- herba dendrobii
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Abstract
The invention discloses the medicated tea of a kind of benefiting qi and nourishing blood treatment aplastic anemia disease, be made up of the raw material of following weight portion: RADIX CODONOPSIS PILOSULAE from Northwest of China 10 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 5 15 parts, Radix Astragali Preparata 39 parts, Radix Angelicae Sinensis 5 12 parts, 39 parts of Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata 39 parts, Herba Agrimoniae 5 12 parts, Caulis Spatholobi 5 10 parts, Radix Notoginseng 10 30 parts, Radix Aucklandiae (Radix Vladimiriae) 5 10 parts, 10 16 parts of Colla Corii Asini, Carapax et Plastrum Testudinis 5 15 parts, Cortex Cinnamomi 6 15 parts, Herba Epimedii 5 10 parts, 5 10 parts of Cornu Cervi.The invention have the advantage that inventive formulation benefiting qi and nourishing blood, treat aplastic anemia disease, anorexia, middle gas do not save, and improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.
Description
Technical field
The present invention relates to the medicated tea of a kind of benefiting qi and nourishing blood treatment aplastic anemia disease, in particular, relate to a kind of benefit
Gas nourishes blood herb tea formula and preparation method thereof the technical field for the treatment of aplastic anemia disease.
Background technology
Aplastic anemia is divided into congenital and acquired, it is thus achieved that property is divided into again constitutional and Secondary cases, usual aregeneratory
Property anemia refers to insecondary.Its feature has: hematopoietic stem cell and hematopoieticmicroenviron-ment dysfunction, hemopoietic red pulp is fatty
Substitute, cause pancytopenia, Progressive symmetric erythrokeratodermia anemia, hemorrhage and infection, and liver, spleen, lymph node not enlargement are (with teenager residence
Many, man is more than female).Aplastic anemia disease shows as deficiency of both QI and blood, Yang Yin, and all empty, mesh sticks with paste tinnitus, heart beating is breathed hard, edema of lower limbs is eaten
Long-pending do not disappear, anorexia, the symptom such as middle gas not province, can be treated by benefiting qi and nourishing blood.
The most traditional beverage, only focuses on mouthfeel, is of low nutritive value, and does not have a benefiting qi and nourishing blood, treatment aplastic anemia disease,
Improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, drop three-hypers, prevent and treat diabetes and anti-cancer, the aspect such as anticancer
Function, it is impossible to releasing the sufferings of client, and traditional herbal tea is by Traditional medicine infusion, flavour of a drug weight mouthfeel is poor, it is impossible to preserve for a long time.Mesh
Not yet occur a kind of in good taste on front market, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen the drink of body immunity simultaneously
Material.
Summary of the invention
The present invention is directed to the deficiency of existing product, and provide a kind of fresh juice beverage to regulate the effect of human physiological functions,
This beverage have be easily absorbed by the human body, medicinal function is notable, delicious flavour, good mouthfeel, improve self and increase the wriggling of the intestines and stomach,
Cure the disease the medicated tea of a kind of benefiting qi and nourishing blood treatment aplastic anemia disease simultaneously strengthening the advantage such as body immunity.
The medicated tea of a kind of benefiting qi and nourishing blood treatment aplastic anemia disease, is made up of the raw material of following weight portion: RADIX CODONOPSIS PILOSULAE from Northwest of China 10-30
Part, Rhizoma Atractylodis Macrocephalae (parched) 5-15 part, Radix Astragali Preparata 3-9 part, Radix Angelicae Sinensis 5-12 part, Radix Rehmanniae Preparata 3-9 part, Radix Glycyrrhizae Preparata 3-9 part, Herba Agrimoniae 5-12 part, chicken
Caulis seu Radix Schisandrae Henryi 5-10 part, Radix Notoginseng 10-30 part, Radix Aucklandiae (Radix Vladimiriae) 5-10 part, Colla Corii Asini 10-16 part, Carapax et Plastrum Testudinis 5-15 part, Cortex Cinnamomi 6-15 part, Herba Epimedii
5-10 part, Cornu Cervi 5-10 part, Air Bladder pseudosciaenae seu Acipenser 5-10 part, new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae 10-20 part, Mel, water are appropriate.
The preparation processing method of the medicated tea of described a kind of benefiting qi and nourishing blood treatment aplastic anemia disease, comprises the following steps；
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby；
B, fresh for the Herba Dendrobii cleaned up bar is put into microwave oven, keep temperature 50-60 DEG C, carry out heating 10 minutes, then take
Go out to put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time
The Chinese liquor of 52-60 DEG C, time 10-15min, the rotating speed of juice extractor is 20～30r/s；After standing 10 minutes, add the fresh bar of Herba Dendrobii
The distilled water of weight 2-3 times, for the second time juice extractor time 10-15min, juice extractor rotating speed is 80～100r/s, stands 10min；
After carry out third time squeeze the juice, add Herba Dendrobii fresh bar weight 3-5 times distilled water, time 20-30min, juice extractor rotating speed be 100～
150r/s, separates fresh for Herba Dendrobii bar juice with fiber filter, makes the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, cell damage
Rate reaches more than 80%, obtains new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber；The warm water that new fresh grape is put into 50-60 DEG C again cleans dry
After Jing, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated stand-by；
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 100-150 in tank
Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby；
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh
Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 5-10 times of weight, stirring is smashed to 100 mesh, at 30-35
Seal at a temperature of DEG C and preserve 24h, sterilizing, filter, put into unglazed hermetically sealed can, obtain Matrix Solution standby；After extracting Matrix Solution
It is the cellulase of 0.5-0.7% that Pericarpium Vitis viniferae and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10,
Keep 35 DEG C, water soluble dietary fiber can be extracted further after 24h enzymolysis, water soluble dietary fiber is added Matrix Solution
Obtain Matrix Solution II；
E, take mix homogeneously after Cornu Cervi, Radix Angelicae Sinensis, Radix Notoginseng cleaning and sterilizing, respectively with 6 times of weight 85% mol ratio ethanol extractions 2 times,
Each 2 hours, merge 2 Cornu Cervis, Radix Angelicae Sinensis, Radix Notoginseng ethanol extracts, receive alcohol and be evaporated to relative density at 40 DEG C and be
1.15-1.35, prepare Cornu Cervi, Radix Angelicae Sinensis, Radix Notoginseng extract standby；
RADIX CODONOPSIS PILOSULAE from Northwest of China, Colla Corii Asini, Carapax et Plastrum Testudinis mix and blend are put into super micron mill, carries out micronizing and obtain the ultra micro of 300-400 mesh
Mixing fine powders；
Taking Rhizoma Atractylodis Macrocephalae (parched), Radix Astragali Preparata, Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Caulis Spatholobi, Radix Aucklandiae (Radix Vladimiriae), Cortex Cinnamomi, Herba Epimedii, Air Bladder pseudosciaenae seu Acipenser, mixing is all
Even add 30-60 DEG C of warm water soaking 10 minutes after, put into reach in freezer ,-10～-20 DEG C freezing 10-20 minute, form freezing medicine
Block, extracts freezing medicine block and ultra micro mixing fine powders boiling 3 times, adds 1-2 times amount water for the first time, and temperature keeps 100-120
DEG C, carry out infusion 10-20 minute；Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes；For the third time
Adding 6-10 times amount water, temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and is concentrated into the 1/2 of original volume, adds deer
Angle, Radix Angelicae Sinensis, the extract of Radix Notoginseng, obtain Matrix Solution III standby；
F, take Matrix Solution I through instantaneous high-temperature 110-130 DEG C, 1-2 minute, put into material-compound tank；Take Matrix Solution II through mesh
Number be 100 mesh fine filter filter after put into material-compound tank；Take Matrix Solution III again to put into after the fine filter filter that mesh number is 60 mesh
In material-compound tank；
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is:
Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae；
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, seal through bottle capper and load in vial,
Packaged vial puts into temperature 100～120 DEG C, 1.5MP, sterilization in 15～21 minutes steam ovens, packaging, vanning.
Further: step B) in, after new fresh grape cleans up, put into reach in freezer ,-10～-20 DEG C freezing 5-10 minute,
Make Fructus Vitis viniferae freeze, after taking out nature defrosting, then carry out Fructus Vitis viniferae meat and Pericarpium Vitis viniferae detached job.
Further: step H) described in material-compound tank endobasal-body solution I, Matrix Solution II, Matrix Solution III, Oleum Vitis viniferae
Weight proportion be 10:0.2～0.8:5～10:0.5.
RADIX CODONOPSIS PILOSULAE from Northwest of China, invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat
Quench one's thirst.
The Rhizoma Atractylodis Macrocephalae, bitter in the mouth, sweet, warm in nature;Return spleen, stomach warp;Fragrance matter is soft, can rise and can drop, keep and do not walk to have invigorating the spleen and benefiting QI,
Dampness diuretic, strengthening superficial resistance to stop perspiration.
Radix Astragali Preparata, returns lung, spleen, liver, kidney channel.Enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering
With wide antibacterial action.
Radix Angelicae Sinensis, sweet, pungent, warm, return liver, the heart, spleen channel, enrich blood；Invigorate blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.
Radix Rehmanniae Preparata, sweet, tepor.Returning liver, kidney channel, yin nourishing of enriching blood, life essence-filling, marrow-benefitting, sweet Wen Zhirun, nourishing YIN benefit essence is with hemopoietic.
Radix Glycyrrhizae Preparata, and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Benefiting qi and nourishing yin, spleen reinforcing stomach function regulating, Yiqi and vein recovery.For spleen
Insufficiency of stomach is weak, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse, can solve Radix Aconiti Lateralis Preparata poison.
Herba Agrimoniae is bitter, cool.Return stomach, liver, spleen, lung, large intestine channel.Relieve internal heat anticancer, cooling blood for hemostasis, detumescent of healing the wounds.
Caulis Spatholobi, relaxing muscles and tendons to promote blood circulation；Nourishing blood for regulating menstruation.Main numb hand and foot；Quadriplegia;Rheumatic arthralgia;Women has through uncomfortable;Bitterly
Warp;Amenorrhea.Enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Radix Notoginseng, enriches blood, invigorates blood circulation, for physical weakness, inappetence, neurasthenia, fatigue.
The Radix Aucklandiae, the abdominal distention caused by stagnation of QI in spleen and stomach, lack of appetite vomiting, the hypochondriac pain caused for QI stagnation of the liver and galibladder, spleen invigorating disappears stagnant.
The stagnant gas of adjustable gastrointestinal.
Colla Corii Asini, YIN nourishing of enriching blood, moisturize, hemostasis.For blood deficiency and yellow complexion, dizziness cardiopalmus, dysphoria and insomnia, xeropulmonary cough.
Carapax et Plastrum Testudinis, salty, sweet, flat, enter liver, kidney two warp.Primary efficacy is nourishing YIN for suppressing the hyperactive YANG, replenishing YIN and removing heat, Kidney-invigorating and tendon-reinforcing, only collapses treatment
Leakage, the kidney invigorating benefit heart, eliminating carbuncle control skin ulcer.
Cortex Cinnamomi, complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.
Herba Epimedii, abnormal smells from the patient is pungent, warm, nontoxic.Warm in nature do not tremble with fear, can benefit vital essence.
Cornu Cervi, the effect such as kidney-replenishing, benefiting essence-blood, bone and muscle strengthening, promoting the circulation of blood detumescence.
The natural tradition medicinal and edible Chinese medicine above with multiple health care is share, blood circulation promoting and blood stasis dispelling, treats purpura disease,
Improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.Joining of each component is screened by great many of experiments
Ratio, scientific and reasonable；And whole preparation technology is rationally and extract drugs rate efficiency is high, the effective one-tenth in raw material can be retained well
Point, do not bring any impurity, and sweet mouthfeel into, have no side effect.
The invention has the beneficial effects as follows:
1, the formula of the present invention, has promoting the production of body fluid to quench thirst, gastric acid secretion, helps digest, and health body-building has calm nerves and declines
Weak, lessen fatigue, containing various trace elements such as calcium, ferrum, zinc, selenium, sodium etc., raising body immunity, defying age, toxin expelling are supported
Face, nourish taste, three-hypers drops, to prevent and treat diabetes and anti-cancer, the aspect such as anticancer the most powerful, regulates human physiological functions.
2, the present invention is rich in anthocyanidin, it is possible to protection human body is from the damage of free radical, it is possible to strengthens blood vessel elasticity, relax
Blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect；Immune system ability can be strengthened, there is strong anti-oxidation, resist
Suddenly change, alleviate the function such as hepatosis, protection cardiovascular；
3, the Chinese herbal medicine such as Rhizoma Atractylodis Macrocephalae (parched), Radix Astragali Preparata, Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Caulis Spatholobi, Radix Aucklandiae (Radix Vladimiriae), Cortex Cinnamomi, Herba Epimedii are added
There is benefiting qi and nourishing blood, treat aplastic anemia disease, improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, resisting fatigue
Etc. function.
4, the products taste that the production technology of the present invention and preparation method draw is sour-sweet tasty and refreshing, rich in dendrobium polysaccharide, has
The highest health care and medical value, long-term drink can with YIN nourishing skin care, change skin colour, defying age, life lengthening, and
Carrying and drink conveniently, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen the beverage of body immunity simultaneously, the shelf-life is up to 1-
2 years.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about
The present invention, but and it is not so limited the present invention.
Embodiment 1
The medicated tea of a kind of benefiting qi and nourishing blood treatment aplastic anemia disease, is made up of the raw material of following weight portion: RADIX CODONOPSIS PILOSULAE from Northwest of China 30 parts, stir-fry are in vain
Art 15 parts, Radix Astragali Preparata 9 parts, Radix Angelicae Sinensis 12 parts, 9 parts of Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata 9 parts, Herba Agrimoniae 12 parts, Caulis Spatholobi 10 parts, Radix Notoginseng 30 parts, wide
The Radix Aucklandiae 10 parts, 16 parts of Colla Corii Asini, Carapax et Plastrum Testudinis 15 parts, Cortex Cinnamomi 15 parts, Herba Epimedii 10 parts, 10 parts of Cornu Cervi, 8 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15 parts,
Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
The preparation processing method of the medicated tea of a kind of benefiting qi and nourishing blood treatment aplastic anemia disease, described preparation method includes following
Step；
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby；
Fresh for the Herba Dendrobii cleaned up bar is put into microwave oven by B, keeps temperature 50-60 DEG C, carries out heating 10 minutes, further take out
Put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content 52 of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time
DEG C Chinese liquor, time 15min, the rotating speed of juice extractor is 30r/s；After standing 10 minutes, add the steaming of Herba Dendrobii fresh bar weight 2.5 times
Distilled water, for the second time juice extractor time 15min, juice extractor rotating speed is 80r/s, stands 10min；After carry out third time squeeze the juice, add
The distilled water of Herba Dendrobii fresh bar weight 3-5 times, time 30min, juice extractor rotating speed is 150r/s, by fresh for Herba Dendrobii bar juice and fiber mistake
Filter separate, make the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, broken cell rate reaches more than 80%, obtain new fresh Herba Dendrobii juice and
Herba Dendrobii fresh bar fiber；Again new fresh grape is put into after the warm water of 55 DEG C cleans up, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated
Stand-by；After new fresh grape cleans up, put into reach in freezer ,-10 ~-20 DEG C of freezings 10 minutes, make Fructus Vitis viniferae freeze, take out certainly
After so thawing, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job.
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 120 in tank
Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby；
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh
Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 6 times of weight, stirring is smashed to 100 mesh, 30-35 DEG C of temperature
Degree lower seal preserves 24h, sterilizing, filters, puts into unglazed hermetically sealed can, obtain Matrix Solution standby；Extract the Fructus Vitis viniferae after Matrix Solution
It is the cellulase of 0.5-0.7% that skin and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10, keeps
35 DEG C, water soluble dietary fiber can be extracted after 24h enzymolysis further, water soluble dietary fiber is added Matrix Solution and obtains
Matrix Solution II；；Rich in anthocyanidin in Pericarpium Vitis viniferae, it is possible to protection human body is from the damage of free radical, it is possible to enhancing blood vessel elasticity,
Lax blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect；Immune system ability can be strengthened, there is strong antioxygen
Change, mutation, alleviate hepatosis, protection function, Pericarpium Vitis viniferae and the Herba Dendrobii fresh bar fiber such as cardiovascular together with stir smash through
Anthocyanidin mentioned by hydromel, can protect the quality of anthocyanidin while farthest extracting anthocyanidin.By water solublity meals
Food fiber adds Matrix Solution and obtains Matrix Solution II, can increase effect of the wriggling of the intestines and stomach, it is ensured that metabolic waste is normally discharged
External；Adsorb various metabolic waste, be allowed to normally excrete, improve the comprehensive utilization value of Herba Dendrobii.
E, take mix homogeneously after Cornu Cervi, Radix Angelicae Sinensis, Radix Notoginseng cleaning and sterilizing, respectively with 6 times of weight 85% mol ratio ethanol extractions 2
Secondary, each 2 hours, merge 2 Cornu Cervis, Radix Angelicae Sinensis, Radix Notoginseng ethanol extracts, receive alcohol and be evaporated to relative density at 40 DEG C and be
1.15-1.35, prepare Cornu Cervi, Radix Angelicae Sinensis, Radix Notoginseng extract standby；
RADIX CODONOPSIS PILOSULAE from Northwest of China, Colla Corii Asini, Carapax et Plastrum Testudinis mix and blend are put into super micron mill, carries out micronizing and obtain the ultra micro of 300-400 mesh
Mixing fine powders；
Taking Rhizoma Atractylodis Macrocephalae (parched), Radix Astragali Preparata, Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Caulis Spatholobi, Radix Aucklandiae (Radix Vladimiriae), Cortex Cinnamomi, Herba Epimedii, Air Bladder pseudosciaenae seu Acipenser, mixing is all
Even add 30-60 DEG C of warm water soaking 10 minutes after, put into reach in freezer ,-10～-20 DEG C freezing 10-20 minute, form freezing medicine
Block, extracts freezing medicine block and ultra micro mixing fine powders boiling 3 times, adds 1-2 times amount water for the first time, and temperature keeps 100-120
DEG C, carry out infusion 10-20 minute；Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes；For the third time
Adding 6-10 times amount water, temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and is concentrated into the 1/2 of original volume, adds deer
Angle, Radix Angelicae Sinensis, the extract of Radix Notoginseng, obtain Matrix Solution III standby；
The hard to bear medicine boiled is pulverized and improves its extract drugs efficiency, make whole formula drug effect farthest be utilized.
F, take Matrix Solution I through instantaneous high-temperature 120 DEG C, 1-2 minute, put into material-compound tank；Take Matrix Solution II through mesh
Number be 100 mesh fine filter filter after put into material-compound tank；Take Matrix Solution III again to put into after the fine filter filter that mesh number is 60 mesh
In material-compound tank；
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is:
Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae；Supercritical extraction can be
Extract under room temperature 37 DEG C and CO2 gas blanket, effectively prevent oxidation and the loss of heat-sensitive substance.Therefore,
The effective ingredient of medicinal plants is remain in extract, and can be high boiling point, low volatility, the easy material being pyrolyzed the lowest
Extract under its boiling temperature；
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, and described material-compound tank endobasal-body solution I, matrix are molten
Liquid II, Matrix Solution III, the weight proportion of Oleum Vitis viniferae are 10:0.5:6:0.5., seal through bottle capper and load vial
In, packaged vial puts into temperature 100～120 DEG C, 1.5MP, sterilization in 15～21 minutes steam ovens, packaging, dress
Case, carries and drinks conveniently, and the shelf-life is up to 1-2.
Embodiment 2
The medicated tea of a kind of benefiting qi and nourishing blood treatment aplastic anemia disease, is made up of the raw material of following weight portion: RADIX CODONOPSIS PILOSULAE from Northwest of China 15 parts, stir-fry are in vain
Art 10 parts, Radix Astragali Preparata 8 parts, Radix Angelicae Sinensis 10 parts, 8 parts of Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata 8 parts, Herba Agrimoniae 10 parts, Caulis Spatholobi 8 parts, Radix Notoginseng 15 parts, wide
The Radix Aucklandiae 8 parts, 12 parts of Colla Corii Asini, Carapax et Plastrum Testudinis 10 parts, Cortex Cinnamomi 10 parts, Herba Epimedii 8 parts, 8 parts of Cornu Cervi, 5 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 10 parts, Portugal
10 parts of grape, Mel, water are appropriate.Processing method is with embodiment 1.
Embodiment 3
The medicated tea of a kind of benefiting qi and nourishing blood treatment aplastic anemia disease, is made up of the raw material of following weight portion: RADIX CODONOPSIS PILOSULAE from Northwest of China 10 parts, stir-fry are in vain
Art 5 parts, Radix Astragali Preparata 3 parts, Radix Angelicae Sinensis 5 parts, 3 parts of Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata 3 parts, Herba Agrimoniae 5 parts, Caulis Spatholobi 5 parts, Radix Notoginseng 10 parts, Radix Aucklandiae (Radix Vladimiriae)
5 parts, 10 parts of Colla Corii Asini, Carapax et Plastrum Testudinis 5 parts, Cortex Cinnamomi 6 parts, Herba Epimedii 5 parts, 5 parts of Cornu Cervi, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 20 parts, Fructus Vitis viniferae 20
Part, Mel, water are appropriate.Processing method is with embodiment 1.
Clinical experiment divides three parts:
(1) animal acute toxicity and chronic toxicity experiment:
1, animal acute toxicity test
Medicine: the embodiment of the present invention 1, embodiment 2 and embodiment 3 medicated tea add the medicated tea powder paste that rice flour is made.
Experimental animal: regular grade NIH mice, body weight 18g ± 2g, male and female half and half.
Method and result:
By three kinds of each 50g of medicated tea, add rice flour.Experiment mice is randomly divided into three groups of male and female half and half, respectively three kinds of medicated tea of feeding
Powder is stuck with paste, volume 1ml/10g body weight, and close observation 8 hours is also noted down, and continues to observe 7 days；In 7 days, mice is without death, OK
For vivaciously, food ration is as usual, and hair color light is without loose dirt, without fainting from fear addicted to saliva, and eye, mouth, nose, ear and crissum secretions without exception,
Without the rotten toe that docks.5 execution of selection from three groups respectively, finding of naked eye: the important organs such as the heart, liver, lung, gastric and thymus, not
See abnormal change, show that two kinds of these nutritive powders are all without acute toxicity.
2, long-term toxicity test for animals
Medicine: the embodiment of the present invention 1, embodiment 2 and embodiment 3 gained medicated tea add the medicated tea powder paste that rice flour is made.
Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.
Method and result:
The configuration that three kinds of medicated tea powder are stuck with paste: be divided into high, medium and low three dosage groups, respectively the 200 of edible for patients amount, 100,
50g；Experimental mouse is randomly divided into three groups, and the medicated tea powder that feeding modulates continuously respectively is stuck with paste, and continuous feeding 40 days observes animal
General toxic reaction and the order of severity, place after death by rule of operation check each position, and carry out hematology, ALT, BUN and the heart,
The pathological examination of the main organs such as liver, spleen, lung, kidney, stomach；
Through long-term feeding, all there is not toxic reaction in two groups of rats.Growth promoter is good.Macroscopic appearance and main organs have no
Abnormal.Peripheral hemogram and Serum ALT, BUN compare with matched group without pathologic change.The pathological replacement heart, liver, spleen, lung, kidney, stomach
Deng the most significant change, it is understood that through proved by pathology, three kinds of medicated tea powder are stuck with paste and showed animal without chronic toxicity.
By two above toxicity test, it was demonstrated that the medicated tea that the present invention is made by embodiment 1, embodiment 2 and embodiment 3 is
Safety, have no side effect, can be used to clinical patients is carried out clinical trial.
3, the embodiment of the present invention drinks effect research:
(1) investigation method:
1. crowd is drunk: general population
2. Ganderwa: 30 days
3. number is drunk: 50 people
4. drinking method: 3 times for each person every day, ante cibum each 500mL
5. index: substantially feel after drinking that all empty, mesh sticks with paste tinnitus, heart beating is breathed hard, lower limb float for easy fatigue, deficiency of both QI and blood, Yang Yin
The transference cures such as swollen food stagnation does not disappears, anorexia, middle gas not province, and mouthfeel is the most sour-sweet for effective；After drinking sensation easily tired,
Deficiency of both QI and blood, Yang Yin all empty, mesh stick with paste tinnitus, heart beating is breathed hard, edema of lower limbs, food stagnation do not disappear, anorexia, middle gas do not save symptom and delays
Solve, and mouthfeel is the most sour-sweet, be designated as effectively.It is invalid to be then designated as without obvious comfort after drinking.
(2) survey result
Survey result is shown in Table 1.Be test result indicate that by table 1, embodiment 1,2,3 has the respondent of 98% to feel that the present invention is carried
The beverage mouthfeel of confession is the most sour-sweet, and above-mentioned clinical symptom disappearance or be eased, the respondent of only 2% drink after without substantially
Increase comfort.
The each embodiment of table 1 drinks effect research table
| Group/effect | Obvious effective rate (number) | Effective percentage (number) | Inefficiency (number) |
| Embodiment 1 | 44%(22) | 54%(27) | 2%(1) |
| Embodiment 2 | 42%(21) | 56%(28) | 2%(1) |
| Embodiment 3 | 42%(21) | 56%(28) | 2%(1) |
Embodiment contrast groups A
Comparative example 4,5,6 is added without the nutrition such as new fresh Herba Dendrobii, Fructus Vitis viniferae, Mel, water soluble dietary fiber and Oleum Vitis viniferae and becomes
Point, according to the raw material that the Chinese medicine part of embodiment 1,2,3 above is original, preparation for processing is traditional side of boiling
Method；The investigation method of using method and using effect is with above.
Table 2 embodiment contrast groups A drinks effect research
| Group/effect | Obvious effective rate (number) | Effective percentage (number) | Inefficiency (number) |
| Comparative example 4 | 36%(18) | 40%(20) | 24%(12) |
| Comparative example 5 | 40%(20) | 40%(20) | 20%(10) |
| Comparative example 6 | 46%(23) | 34%(17) | 20%(10) |
Embodiment contrast groups B
Comparative example 7,8,9 is added without the nutrition such as new fresh Herba Dendrobii, Fructus Vitis viniferae, Mel, water soluble dietary fiber and Oleum Vitis viniferae and becomes
Point, according to the raw material that the Chinese medicine part of embodiment 1,2,3 above is original, preparation for processing uses in embodiment 1
The preparation processing method of step E；The investigation method of using method and using effect is with above.
Table 3 embodiment contrast groups B drinks effect research
| Group/effect | Obvious effective rate (number) | Effective percentage (number) | Inefficiency (number) |
| Comparative example 7 | 32%(16) | 56%(28) | 12%(6) |
| Comparative example 8 | 28%(14) | 52%(31) | 10%(5) |
| Comparative example 9 | 36%(18) | 52%(26) | 12%(6) |
Embodiment contrast groups C
The processing method of comparative example 10,11,12 respectively corresponding embodiment 1,2,3 and formula, different be formula in
Without Air Bladder pseudosciaenae seu Acipenser composition；The investigation method of using method and using effect is with above.
Table 4 embodiment contrast groups C drinks effect research
| Group/effect | Obvious effective rate (number) | Effective percentage (number) | Inefficiency (number) |
| Comparative example 10 | 44%(22) | 46%(23) | 10%(5) |
| Comparative example 11 | 38%(19) | 50%(25) | 12%(6) |
| Comparative example 12 | 40%(20) | 48%(24) | 12%(6) |
Conclusion:
Contrasted by table 2 and table 1 and can be seen that
The inefficient number of embodiment contrast groups A is about 10 times of embodiment 1,2,3；This shows Chinese crude drug formula of the present invention
And between the nutritional labeling such as water soluble dietary fiber and Oleum Vitis viniferae, creating the most collaborative pharmacological action, aqueous soluble dietary is fine
Dimension increases effect of the wriggling of the intestines and stomach and promotes the human body absorption to ingredient, it is ensured that metabolic waste normally excretes, additionally
The anthocyanidin that contains in Pericarpium Vitis viniferae, resveratrol, have strong anti-oxidation, mutation, alleviate hepatosis, protection cardiovascular etc.
Function, strengthens immune system ability；Associate with Chinese medicine and improve assimilation effect and improve the mouthfeel of Chinese medicine, through the essence of the present invention simultaneously
The extraction of heart configuration and at utmost ingredient, Chinese crude drug formula of the present invention and preparation method occur in that beat all technology
Effect.
Table 2 and table 3 contrast can be seen that
About inefficient number is embodiment contrast groups B 2 times of embodiment contrast groups A, embodiment contrast groups B and traditional
Embodiment contrast groups A of boiling method has compared significant raising at therapeutic effect, and this shows that Chinese crude drug of the present invention is through step
The preparation processing method of rapid E has had significant raising than traditional boiling method, the extraction degree of active ingredient.
Table 1 is compared with table 4:
The formula of embodiment contrast groups C does not contains Air Bladder pseudosciaenae seu Acipenser, and the invalid number of embodiment contrast groups C is 5 times of left sides of embodiment 1,2,3
Right；And effective percentage number has and has declined；Air Bladder pseudosciaenae seu Acipenser can strengthen gastrointestinal digestive and absorptive functions, improves appetite, is conducive to anti-
Control the diseases such as inappetence, anorexia, dyspepsia, abdominal distention, constipation, show Air Bladder pseudosciaenae seu Acipenser serve in formula collaborative and priming return through
Effect, Air Bladder pseudosciaenae seu Acipenser application effect achieves unexpected technique effect.
In sum, the medicated tea of a kind of benefiting qi and nourishing blood treatment aplastic anemia disease that the present invention provides has sour-sweet mouth
Sense, there is the most again treatment easily fatigue, deficiency of both QI and blood, Yang Yin all empty, mesh paste tinnitus simultaneously, heart beating is breathed hard, edema of lower limbs, food stagnation not
Disappear, merit that anorexia, middle gas do not save, improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, fall three-hypers, preventing and treating
Diabetes and anti-cancer, the aspect such as anticancer are the most powerful.And all raw materials is all from medicine-food two-purpose natural plants, have no side effect.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (7)
1. the medicated tea of a benefiting qi and nourishing blood treatment aplastic anemia disease, it is characterised in that be made up of the raw material of following weight portion: west
Radix Codonopsis 10-30 part, Rhizoma Atractylodis Macrocephalae (parched) 5-15 part, Radix Astragali Preparata 3-9 part, Radix Angelicae Sinensis 5-12 part, Radix Rehmanniae Preparata 3-9 part, Radix Glycyrrhizae Preparata 3-9 part, Herba Agrimoniae
5-12 part, Caulis Spatholobi 5-10 part, Radix Notoginseng 10-30 part, Radix Aucklandiae (Radix Vladimiriae) 5-10 part, Colla Corii Asini 10-16 part, Carapax et Plastrum Testudinis 5-15 part, Cortex Cinnamomi 6-15
Part, Herba Epimedii 5-10 part, Cornu Cervi 5-10 part, Air Bladder pseudosciaenae seu Acipenser 5-10 part, new fresh Herba Dendrobii 10-20 part, Fructus Vitis viniferae 10-20 part, Mel, water are fitted
Amount.
The medicated tea of a kind of benefiting qi and nourishing blood the most according to claim 1 treatment aplastic anemia disease, it is characterised in that by following
The raw material of weight portion is made: RADIX CODONOPSIS PILOSULAE from Northwest of China 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, Radix Astragali Preparata 8 parts, Radix Angelicae Sinensis 10 parts, 8 parts of Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata 8 parts,
Herba Agrimoniae 10 parts, Caulis Spatholobi 8 parts, Radix Notoginseng 15 parts, Radix Aucklandiae (Radix Vladimiriae) 8 parts, 12 parts of Colla Corii Asini, Carapax et Plastrum Testudinis 10 parts, Cortex Cinnamomi 10 parts, Herba Epimedii 8 parts,
8 parts of Cornu Cervi, 8 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
The medicated tea of a kind of benefiting qi and nourishing blood the most according to claim 1 treatment aplastic anemia disease, it is characterised in that by following
The raw material of weight portion is made: RADIX CODONOPSIS PILOSULAE from Northwest of China 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 5 parts, Radix Astragali Preparata 3 parts, Radix Angelicae Sinensis 5 parts, 3 parts of Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata 3 parts, celestial being
Crane grass 5 parts, Caulis Spatholobi 5 parts, Radix Notoginseng 10 parts, Radix Aucklandiae (Radix Vladimiriae) 5 parts, 10 parts of Colla Corii Asini, Carapax et Plastrum Testudinis 5 parts, Cortex Cinnamomi 6 parts, Herba Epimedii 5 parts, Cornu Cervi 5
Part, 5 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 10 parts, Fructus Vitis viniferae 10 parts, Mel, water are appropriate.
The medicated tea of a kind of benefiting qi and nourishing blood the most according to claim 1 treatment aplastic anemia disease, it is characterised in that by following
The raw material of weight portion is made: RADIX CODONOPSIS PILOSULAE from Northwest of China 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Radix Astragali Preparata 9 parts, Radix Angelicae Sinensis 12 parts, 9 parts of Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata 9 parts,
Herba Agrimoniae 12 parts, Caulis Spatholobi 10 parts, Radix Notoginseng 30 parts, Radix Aucklandiae (Radix Vladimiriae) 10 parts, 16 parts of Colla Corii Asini, Carapax et Plastrum Testudinis 15 parts, Cortex Cinnamomi 15 parts, Herba Epimedii 10
Part, 10 parts of Cornu Cervi, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 20 parts, Fructus Vitis viniferae 20 parts, Mel, water are appropriate.
5. the preparation processing method of the medicated tea of a benefiting qi and nourishing blood treatment aplastic anemia disease, it is characterised in that include following step
Suddenly；
A, fresh for Herba Dendrobii bar is put into service sink, remove surface clay stain, the fresh bar of screening high-quality Herba Dendrobii, dry standby；
B, fresh for the Herba Dendrobii cleaned up bar is put into microwave oven, keep temperature 50-60 DEG C, carry out heating 10 minutes, then take
Go out to put into rotating centrifugal juice extractor, carry out three times and squeeze the juice, add the alcohol content of Herba Dendrobii fresh bar weight 0.1-0.5 times for the first time
The Chinese liquor of 52-60 DEG C, time 10-15min, the rotating speed of juice extractor is 20～30r/s；After standing 10 minutes, add the fresh bar of Herba Dendrobii
The distilled water of weight 2-3 times, for the second time juice extractor time 10-15min, juice extractor rotating speed is 80～100r/s, stands 10min；
After carry out third time squeeze the juice, add Herba Dendrobii fresh bar weight 3-5 times distilled water, time 20-30min, juice extractor rotating speed be 100～
150r/s, separates fresh for Herba Dendrobii bar juice with fiber filter, makes the fiber separation rate of the fresh bar of Herba Dendrobii reach more than 95%, cell damage
Rate reaches more than 80%, obtains new fresh Herba Dendrobii juice and Herba Dendrobii fresh bar fiber；The warm water that new fresh grape is put into 50-60 DEG C again cleans dry
After Jing, Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae are separated stand-by；
C, Herba Dendrobii fresh bar juice is put into and is put in pressure pan with Fructus Vitis viniferae meat, keeps pressure 0.5MP, temperature to keep 100-150 in tank
Degree, carries out infusion 10 minutes, obtains Matrix Solution I standby；
D, fresh for the Herba Dendrobii of separation bar fiber and Pericarpium Vitis viniferae are put into unglazed hermetically sealed can, in hermetically sealed can, add that to be equivalent to Herba Dendrobii fresh
Bar fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the distilled water of 5-10 times of weight, stirring is smashed to 100 mesh, at 30-35
Seal at a temperature of DEG C and preserve 24h, sterilizing, filter, put into unglazed hermetically sealed can, obtain Matrix Solution standby；After extracting Matrix Solution
It is the cellulase of 0.5-0.7% that Pericarpium Vitis viniferae and Herba Dendrobii fresh bar fiber add mass volume ratio, adds the water of the mass ratio of 1:10,
Keep 35 DEG C, water soluble dietary fiber can be extracted further after 24h enzymolysis, water soluble dietary fiber is added Matrix Solution
Obtain Matrix Solution II；
E, take mix homogeneously after Cornu Cervi, Radix Angelicae Sinensis, Radix Notoginseng cleaning and sterilizing, respectively with 6 times of weight 85% mol ratio ethanol extractions 2 times,
Each 2 hours, merge 2 Cornu Cervis, Radix Angelicae Sinensis, Radix Notoginseng ethanol extracts, receive alcohol and be evaporated to relative density at 40 DEG C and be
1.15-1.35, prepare Cornu Cervi, Radix Angelicae Sinensis, Radix Notoginseng extract standby；
RADIX CODONOPSIS PILOSULAE from Northwest of China, Colla Corii Asini, Carapax et Plastrum Testudinis mix and blend are put into super micron mill, carries out micronizing and obtain the ultra micro of 300-400 mesh
Mixing fine powders；
Taking Rhizoma Atractylodis Macrocephalae (parched), Radix Astragali Preparata, Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata, Herba Agrimoniae, Caulis Spatholobi, Radix Aucklandiae (Radix Vladimiriae), Cortex Cinnamomi, Herba Epimedii, Air Bladder pseudosciaenae seu Acipenser, mixing is all
Even add 30-60 DEG C of warm water soaking 10 minutes after, put into reach in freezer ,-10～-20 DEG C freezing 10-20 minute, form freezing medicine
Block, extracts freezing medicine block and ultra micro mixing fine powders boiling 3 times, adds 1-2 times amount water for the first time, and temperature keeps 100-120
DEG C, carry out infusion 10-20 minute；Second time adds 4-6 times amount water, and temperature keeps 80-100 DEG C, carries out infusion 10 minutes；For the third time
Adding 6-10 times amount water, temperature keeps 120-150 DEG C, carries out infusion 30 minutes, filters, and is concentrated into the 1/2 of original volume, adds deer
Angle, Radix Angelicae Sinensis, the extract of Radix Notoginseng, obtain Matrix Solution III standby；
F, take Matrix Solution I through instantaneous high-temperature 110-130 DEG C, 1-2 minute, put into material-compound tank；Take Matrix Solution II through mesh
Number be 100 mesh fine filter filter after put into material-compound tank；Take Matrix Solution III again to put into after the fine filter filter that mesh number is 60 mesh
In material-compound tank；
G, by Semen Vitis viniferae through vacuum outgas, then use CO2 supercritical fluid extraction, the condition of CO2 supercritical fluid extraction is:
Extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min, isolated Oleum Vitis viniferae；
H, three kinds of Matrix Solutions are stirring evenly and then adding into Oleum Vitis viniferae at material-compound tank, seal through bottle capper and load in vial,
Packaged vial puts into temperature 100～120 DEG C, 1.5MP, sterilization in 15～21 minutes steam ovens, packaging, vanning.
The preparation processing method of the medicated tea of a kind of benefiting qi and nourishing blood the most according to claim 5 treatment aplastic anemia disease, its
It is characterised by, step B) in, after new fresh grape cleans up, put into reach in freezer ,-10～-20 DEG C freezing 5-10 minute, make
Fructus Vitis viniferae freezes, and after taking out nature defrosting, then carries out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job.
The preparation processing method of the medicated tea of a kind of benefiting qi and nourishing blood the most according to claim 5 treatment aplastic anemia disease, its
Be characterised by, step H) described in material-compound tank endobasal-body solution I, Matrix Solution II, Matrix Solution III, the weight of Oleum Vitis viniferae
Proportioning is 10:0.2～0.8:5～10:0.5.
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| CN103300450A (en) * | 2013-06-14 | 2013-09-18 | 浙江大学 | Preparation method of raw dendrobium officinale pulp beverage |
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|---|---|---|---|---|
| CN103300450A (en) * | 2013-06-14 | 2013-09-18 | 浙江大学 | Preparation method of raw dendrobium officinale pulp beverage |
Non-Patent Citations (2)
| Title |
|---|
| 宋芳等: "超临界二氧化碳萃取葡萄籽油及其脂肪酸的分析", 《中国食品工业》 * |
| 李文亮等: "《千家妙方 上册》", 31 May 1999, 战士出版社 * |
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Application publication date: 20161207 |
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