CN104872680A - Healthcare food composition capable of boosting immunity - Google Patents
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- CN104872680A CN104872680A CN201510353838.3A CN201510353838A CN104872680A CN 104872680 A CN104872680 A CN 104872680A CN 201510353838 A CN201510353838 A CN 201510353838A CN 104872680 A CN104872680 A CN 104872680A
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- 229910052698 phosphorus Inorganic materials 0.000 description 1
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- 238000005498 polishing Methods 0.000 description 1
- 229920001184 polypeptide Chemical class 0.000 description 1
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- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
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- 231100000820 toxicity test Toxicity 0.000 description 1
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- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a healthcare food composition with the immunity boosting function. The composition comprises, by mass, 125-155 parts of ginseng powder, 40-50 parts of poria cocos extract, 34-42 parts of hawthorn extract, 27-33 parts of date extract, 22-28 parts of lotus nut extract, 20-25 parts of lily extract and a proper number of auxiliary materials capable of being accepted in pharmacy. The composition is based on the traditional Chinese medicine theory, in combination with modern science research results, experimental data serve as bases, the components are scientifically compatible, synergistic interaction is achieved, and the healthcare food composition is safe, free of poison and capable of definitely and effectively improving the human immunity function.
Description
Technical field
The present invention relates to a kind of health food for immunocompromised person and preparation method thereof.
Background technology
The health of hypoimmunity is easy to infected or cancer stricken; A variety of causes makes immune system normally can not play protective effect, and in the case, very easily recruit the infection such as malignant bacteria, virus, fungi, therefore hypoimmunity the most directly shows is exactly liable to illness.Because of often ill, increased the weight of the consumption of body, thus generally have a delicate constitution, malnutritive, One's spirits are drooping, fatigue and weak, appetite reduction, the performance such as sleep-disorder, sick, have an injection and take medicine the normal potluck that just gets married.At every turn sickly all to could to recover for a long time, and usually recurrent exerbation.If things go on like this can cause health and intelligence development bad, also easily bring out major disease.
Traditional Chinese medical science immunity one word, though head sees 19th century Li Shi " immune class side " (see " mansion, the Hangzhou will descriptive accounts of books in dynastic histories "), traditional Chinese medical science immunity thought is of long standing and well established.In Huangdi's Internal Classics before more than 2,000 years, just existing discussion, through the supplementary performance of doctor's later age, makes traditional Chinese medical science immunity thought constantly be developed.Medical science monumental work Huangdi's Internal Classics as Ancient Times in China is just pointed out " in healthy tendency deposits, heresy can not be done, gathering of heresy, and its gas must be empty ".Ancients think that disease is the process of human righteousness and this pair contradiction struggle of disease and evil.Be summed up as negative and positive to inside of human body paradoxical movement to be in harmonious proportion, vim and vigour are biochemical, the premunition of human body and naturally repair power, are referred to as healthy tendency, think that it is the comprehensive embodiment of human body disease-resistance substance and resistance against diseases." preventing diseases instead for the treatment of diseases ", " strengthening the body resistance to consolidate the constitution " scheduling theory of the traditional Chinese medical science, all includes immunology thought.
Develop the health food based on Chinese medicine composition, with develop immunitypty.The problems tool responding actively hypoimmunity, social senilization, inferior health etc. and affect human health is of great significance.
Summary of the invention
The object of the invention is to, a kind of health-care food composition with develop immunitypty function is provided, safety non-toxic, definitely effective.The technical solution used in the present invention is, a kind of health-care food composition of develop immunitypty, it is characterized in that, described composition is made up of following component by ratio of quality and the number of copies: ginseng pulverate 125 ~ 155 parts, tuckahoe extracts 40 ~ 50 parts, haw thorn extract 34 ~ 42 parts, Fructus Jujubae extract 27 ~ 33 parts, Semen Nelumbinis extract 22 ~ 28 parts, Bulbus Lilii extract 20 ~ 25 parts, pharmaceutically acceptable appropriate amount of auxiliary materials.
In above-mentioned formula, be can the raw material buied of market for each component, through after the assay was approved, sieve, weigh, fully mix by conventional method by proportioning.Add pharmaceutically acceptable appropriate amount of auxiliary materials such as starch, gelatin etc. and make granule, capsule, tablet etc.States of matter adaptability and user's compliance is improved, preferred capsule in order to improve.
Preferably, in described composition, the ratio of quality and the number of copies of each component is: ginseng pulverate 140 parts, tuckahoe extracts 45 parts, haw thorn extract 38 parts, Fructus Jujubae extract 30 parts, Semen Nelumbinis extract 25 parts, Bulbus Lilii extract 22 parts.
Further, in described composition, the quality of each component is: ginseng pulverate 140 grams, tuckahoe extracts 45 grams, haw thorn extract 38 grams, Fructus Jujubae extract 30 grams, Semen Nelumbinis extract 25 grams, Bulbus Lilii extract 22 grams; Add pharmaceutically acceptable appropriate amount of auxiliary materials and make 1000 seed lac wafers, 0.3 gram/.Guarantee to take safety and health care curative effect.
In technique scheme:
Ginseng is the dry root welding technology of Araliaceae ginseng Panax ginseng C.A.Mey..Sweet, the micro-hardship of taste, slightly warm in nature, returns spleen, lung, the heart, kidney channel, reinforces vital energy, and multiple arteries and veins takes off admittedly, reinforces the spleen to benefit the lung, promotes the production of body fluid and nourish blood, the effect of intelligence development of calming the nerves.Be mainly used in body empty for de-, the cold weak pulse of limb, insufficiency of the spleen food is few, and the deficiency syndrome of the lung is breathed with cough, and Tianjin wound is thirsty, and interior heat is quenched one's thirst, deficiency of qi and blood, and prolonged illness void is thin, palpitation with fear insomnia, impotence Gong Leng etc.Main component contained by ginseng is carbohydrate, saponins, volatile ingredient etc., organic acid and its ester, enzyme, protein, sterol and glycosides thereof, nitrogen-containing compound, polypeptide class, flavonoids, lignin, inorganic elements and vitamins etc.Wherein ginsenoside, panaxan belong to main chemical compositions.Modern study shows, ginseng has and improves central nervous system and to unify cardiovascular function, improves body's immunity, strengthens organism adaptation ability, strengthen memory, increase appetite, antifatigue, anti-ageing peculiar effect of waiting for a long time.The clinical effect of ginseng often has amphicheirality, and it has " adapting to former state (adaptogen) " effect also person.The adaptability of body can be strengthened, make disorderly function be tending towards normal, play ill curing the disease, anosis effect of promoting longevity.
Poria cocos is the dry sclerotia of On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf.Taste is sweet, light, and property is put down, the thoughts of returning home, lung, kidney, the spleen channel, tool clearing damp and promoting diuresis, invigorating the spleen, effect of the peaceful heart.Be mainly used in oedema oliguria, phlegm and retained fluid is dizzy throbs with fear, and insufficiency of the spleen food is few, has loose bowels in loose stool, confused and worried, palpitation with fear insomnia etc.Poria cocos is classified as top grade by Shennong's Herbal.In Poria cocos, pachymose (Pachymose) is main composition, content is 84.2%, hard alkane (albuminoid) is containing 0.68%, content of cellulose 2.84%, triterpene compound pachymic acid (Tumulasie acid), loose Siberian cocklebur acid (Pmicoic acid), in addition, still containing other compositions such as histidine, choline, glucose.Research shows, pachymaran has various biological activity, and it can not only improve non-specific immune systems function, significantly strengthens the phagocytic function of Turnover of Mouse Peritoneal Macrophages, improves NK cell killing activity; And specific immune system function can be improved, strengthen mouse to the humoral immune reaction of sensitized erythrocyte, promote breeder reaction and the mouse mixed lymphocyte reaction (MLP) of mouse spleen lymphocyte, and strengthen mouse delayed allergy etc.
Hawthorn is the dry mature fruit of rosaceous plant large-fruited Chinese hawthorn Crataegus pinnat ifida Bge.Var.Major N.E.Br. or hawthorn Crataegus pinnatifida Bge..Taste is sour, sweet, and slightly warm in nature, returns spleen, stomach, Liver Channel.There is food digesting stomach fortifying, promoting the circulation of qi scattered silt, change effect of turbid lipopenicillinase.Be mainly used in carnivorous stagnant, gastral cavilty turgor, rush down dysentery stomachache, hemostasis through closing, postpartum stasis blocking, trusted subordinate's shouting pain, chest impediment and cardialgia, hernia pain, hyperlipidemia etc.Hawthorn is the fruit that a kind of people extremely like, has the cultivation history of more than 3,000 year in China, and China has the abundantest Hawthorn Resources country in the world.Fructus Crataegi contains abundant crataegolic acid, oleanolic acid, ursolic acid, tartaric acid, citric acid, chlorogenic acid, malic acid, flavonoids, lipolytic enzyme, L-sorbose, Quercetin, rib yellow rope, Hu Luosu, calcium, phosphorus, iron etc. to health benefit materials.Hawthorn is a kind of conventional Chinese medicine, and the name of " hawthorn " is loaded into this, first appeared in Compendium of Material Medica.Modern pharmacological research shows that hawthorn has the effects such as hypotensive, regulating lipid metabolism, anti-oxidant, develop immunitypty.
Date is the dry mature fruit of Rhamnaceae plant jujube Ziziphus jujuba Mill., and taste is sweet, warm in nature, returns spleen, stomach, the heart channel of Hang-Shaoyin.There is tonifying middle-Jiao and Qi, effect of nourishing blood and tranquilization.Be mainly used in insufficiency of the spleen food few, weak loose stool, the diseases such as hysteria of womam." Jia Shi says woods " is said: " former times has people to obtain Anqi's date, boils begin ripe on 3rd in the south in sea, fragrant hear jujube and has tonifying Qi, enriches blood, effect of anti-ageing and develop immunitypty." it is called as " nutrition and health care ball " and " woody grain ".Common saying is said " every solar eclipse three jujube, bears one's age well throughout one's life ".Date chemical composition from plant is more complicated, and since the eighties in 20th century, the compound found from date plant has kind more than 70.The research of date plant chemical ingredient is mainly concentrated on to the compositions such as triterpenic acid, saponin(e, alkaloid, flavones and sugar former times class.Modern medicine study confirms, date have delay senility, anti-oxidant, improve immunologic function, the effect such as antitumor.
Lotus seeds have another name called lotus reality, lotus rice, and be the dry mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn., taste is sweet, puckery, and property is put down, and returns spleen, kidney, the heart channel of Hang-Shaoyin.There is tonifying spleen antidiarrheal, only band, the puckery essence of kidney-nourishing, effect of mental-tranquilization.Be mainly used in splenasthenic diarrhea, under band, seminal emission, the diseases such as palpitation and insomnia.Lotus seeds have the cultivation history of more than 3000 year in China, and it is top grade that lotus seeds are considered to nourishing since ancient times, widely eats among the people.Lotus seeds, not only containing trace elements such as rich in protein, carbohydrate, vitamin and Ca, Fe, Zn, also contain the functional components such as water-soluble polysaccharide, Flavonoid substances, alkaloid and superoxide dismutase.Modern study shows, lotus seeds not only have abundant nutritional labeling, also has special treatment effect, belongs to one of " being food and medicine " plant variety of Ministry of Public Health's approval.Remove the peel when it is used as medicine, remove the heart, therefore be called in tcm prescription " lotus-seed kernel ".Record lotus seeds and enter spleen, kidney, the heart channel of Hang-Shaoyin in Shennong's Herbal medicine ancient books and records, having clears away heart-fire is amusing, mend stomach antidiarrheal, effects such as improving eyesight, antidiarrheal controlling nocturnal emission with astringent drugs, nourishing vigour of reposing of feeling at ease.Modern pharmacological research also confirms that lotus seeds have the multiple efficacies such as calmness, cardiac stimulant, anti-ageing, develop immunitypty.Semen Nelumbinis polysaccharide can improve interleukin 1 α, the Interleukin 2 Activity of immunosuppressed mice peritoneal macrophage and splenocyte secretion, promote the Spleen cell proliferation stimulated through concanavalin A or lipopolysaccharides, and reduce serum soluble interleukin-1 receptor level, have and strengthen immune effect preferably.
Lily begins to be loaded in Shennong's Herbal, and history tree is all on the books thereafter.For the dry meat scale leaf of liliaceous plant tiger lily Lilium lanci folium Thunb., lily Lilium browniiF.E.Brown var.ViridulumBaker or Lilium tenuifolium Lilium pumilum DC..Taste is sweet, cold in nature.The thoughts of returning home, lung channel.There is Yin nourishing and lung moistening, effect of clearing away the heart fire and tranquillizing.Be mainly used in deficiency of Yin cough caused by dryness, labor is coughed spitting of blood, and dysphoria is palpitated with fear, insomnia and dreamful sleep, absent-mindedly waits disease.Lily is that the Ministry of Public Health examines the first batch of medicine-food two-purpose product passed through, and its nutritional labeling mainly contains the number of chemical materials such as Lilium brownie, lily polysaccharide, phenolic acid glyceride, phospholipid, alkaloids, trace element, amino acid.Modern pharmacological research proves that lily has the effects such as antifatigue, antitumor, develop immunitypty.The lily Thick many candies contained in lily has immunologic enhancement, can significantly improve phagocytic percentage and the phagocytic index of hypoimmunity mice peritoneal macrophage, promotes that hemolysin and hemolysis plaque are formed, promotes lymphocyte transformation.
The pharmacological mechanism of technique scheme is: ginseng sweet Wen Yiqi, strengthening spleen and nourishing stomach, promotes the production of body fluid and nourishes blood as monarch; Poria cocos is sweet light, invigorating the spleen excreting dampness, crataegolic acid, Gan Wen, and food digesting stomach fortifyingization is stagnant, and lotus seeds are sweet flat, the puckery intestines of tonifying spleen, and spleen benefiting and stimulating the appetite, improves a poor appetite, and lily is sweet, is slightly cold, Yin nourishing and lung moistening, beneficial stomach, and Poria cocos, hawthorn, lotus seeds, lily are help others ginseng strengthening the spleen and replenishing qi, are minister altogether; The sweet temperature of date, tonifying middle-Jiao and Qi, strengthens the spleen and stomach, coordinating the drug actions of a prescription, is assistant.
Raw material selected by this product is Chinese medicine material and Chinese medical extract, can improve active principle content, heighten the effect of a treatment with extract; Improve stability and the security of preparation; Reduced volume, reduces the advantages such as dose.
Beneficial effect of the present invention is, based on traditional Chinese medical theory, in conjunction with modern scientific research achievement, take experimental data as foundation, each component scientific compatibility, Synergistic, safety non-toxic, strengthens immune function of human body definitely effectively.
Below in conjunction with detailed description of the invention, the present invention will be further described.
Detailed description of the invention
Embodiment 1: in the health-care food composition of described develop immunitypty, the quality of each component is: ginseng pulverate 140 grams, tuckahoe extracts 45 grams, haw thorn extract 38 grams, Fructus Jujubae extract 30 grams, Semen Nelumbinis extract 25 grams, Bulbus Lilii extract 22 grams.Auxiliary material gelatin hollow capsule meets related request under 2010 editions Pharmacopoeias of the People's Republic of China, two " gelatin hollow capsule " items.Adopt the general production technology of hard shell capsules, comprising: sieve, weigh, mix (preferred incorporation time 30min ~ 40min), filling, polishing, select, pressing plate, external packing, inspection, the main technological steps such as warehouse-in.Make 1000 seed lac wafers, 0.3 gram/.
Get above-mentioned capsule sample contents, according to the Ministry of Public Health " health food inspection and assessment technical specification " (version in 2003), carried out safety toxicology test and animal function test to this product, result shows, this product is safe, nontoxic, effective.Concrete Interventions Requested are as follows:
1. Interventions Requested: Ames tests.Assay: negative.
2. mouse marrow cell micro nuclear test.Assay: negative.
3. mouse inbred strain.Assay: negative.
4. acute oral toxicity test.
Assay: female, male mice acute oral MTD is greater than 15000mg/kgbw, and according to acute toxicity dose grading standard, this sample belongs to nontoxic level.
Within 5.30 days, feed experiment.
Assay: actual dose is female is 4.36g/kgbw/d, 2.88g/kgbw/d, 1.34g/kgbw/d (being equivalent to 109 times of human body recommended amounts, 72 times, 34 times), male is 4.39g/kgbw/d, 2.90g/kgbw/d, 1.35g/kgbw/d (being equivalent to 110 times of human body recommended amounts, 73 times, 34 times).Give rat 30 days by above-mentioned dosage, animal subject ordinary circumstance is good, body weight, food utilization.Organ weights.Organ coefficient change all without exception; Hematological indices and the display of biochemical indicator result, indices is all in normal range (NR); Each internal organs histopathologic examination is showed no the pathological change relevant with given the test agent.Do not observe illeffects.
5. develop immunitypty animal function test.
Assay: this test gives mouse one month with 0.20g/kgbw/d, 0.40g/kgbw/d, 1.20g/kgbw/d tri-dosage per os, carries out mouse cell immunologic function, humoral immune function, monocytes/macrophages function and NK cytoactive detection.Result shows, and 1.20g/kgbw/d group adds ConA hole and increases weight higher than 0g/kgbw/d group with the difference and auricular concha not adding ConA hole absorbance; 1.20g/kgbw/d group phagocytic index a is higher than 0g/kgbw/d group; 1.20g/kgbw/d group NK cytoactive is higher than 0g/kgbw/d group; And difference all has statistical significance (P < 0.05).Result according to the develop immunitypty function test of " health food inspection and assessment technical specification " judges, under this experimental condition, sample has develop immunitypty function.
Embodiment 2 ~ 7: be with the difference of embodiment 1, the formula of described composition is different, sees the following form:
The above-mentioned implementation that the present invention describes is only in order to technical scheme of the present invention is clearly described, and can not be interpreted as and make any restriction to the present invention.The present invention has known multiple alternative or distortion in the art, under the prerequisite not departing from essential meaning of the present invention, all falls into protection scope of the present invention.
Claims (4)
1. the health-care food composition of a develop immunitypty, it is characterized in that, described composition is made up of following component by ratio of quality and the number of copies: ginseng pulverate 125 ~ 155 parts, tuckahoe extracts 40 ~ 50 parts, haw thorn extract 34 ~ 42 parts, Fructus Jujubae extract 27 ~ 33 parts, Semen Nelumbinis extract 22 ~ 28 parts, Bulbus Lilii extract 20 ~ 25 parts, pharmaceutically acceptable appropriate amount of auxiliary materials.
2. the health-care food composition of a kind of develop immunitypty as claimed in claim 1, it is characterized in that, in described composition, the ratio of quality and the number of copies of each component is: ginseng pulverate 140 parts, tuckahoe extracts 45 parts, haw thorn extract 38 parts, Fructus Jujubae extract 30 parts, Semen Nelumbinis extract 25 parts, Bulbus Lilii extract 22 parts.
3. the health-care food composition of a kind of develop immunitypty as claimed in claim 1 or 2, it is characterized in that, said composition makes capsule.
4. the health-care food composition of a kind of develop immunitypty as claimed in claim 1 or 2, it is characterized in that, in described composition, the quality of each component is: ginseng pulverate 140 grams, tuckahoe extracts 45 grams, haw thorn extract 38 grams, Fructus Jujubae extract 30 grams, Semen Nelumbinis extract 25 grams, Bulbus Lilii extract 22 grams; Add pharmaceutically acceptable appropriate amount of auxiliary materials and make 1000 seed lac wafers, 0.3 gram/.
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| CN105919112A (en) * | 2016-06-22 | 2016-09-07 | 延边大学 | Ginseng and fritillary bulb health care food, and preparation method and purpose thereof |
| CN109315780A (en) * | 2018-10-12 | 2019-02-12 | 深圳瑞达生物股份有限公司 | Edible composition and its application |
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| KR20120120515A (en) * | 2011-04-22 | 2012-11-02 | 권기식 | Composition and manufacturing method of functional food containing propolis and herbal extract which has antimicrobial, antioxidant, and immunostimulating activity |
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Application publication date: 20150902 |