CN105963533A

CN105963533A - Preparation method of traditional Chinese medicine for treating chronic pharyngitis and traditional Chinese medicine buccal tablet

Info

Publication number: CN105963533A
Application number: CN201610547828.8A
Authority: CN
Inventors: 杨高林
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-07-12
Filing date: 2016-07-12
Publication date: 2016-09-28

Abstract

The invention discloses a preparation method of a traditional Chinese medicine buccal tablet for treating chronic pharyngitis. The preparation method comprises the following steps: a, vaporizing radix angelicae, bletilla striata, mint, borneol and notopterygium roots by a distillation method to obtain crystal serving as a component 1; b, extracting the other raw materials, except watermelon frost, with ethanol to obtain a component 2; c, decocting the dregs extracted with ethanol in water twice, and mixing and concentrating the extracting solutions to obtain a component 3; and d, mixing the component 2 and the component 3, then concentrating the mixture, adding the watermelon frost and the component 1 and blending the mixture, sterilizing the mixture, and adding fructose or sweetening agent to obtain the buccal tablet. In the step a, the raw medicines, namely the radix angelicae, bletilla striata, mint, borneol and notopterygium roots, are firstly vaporized by the distillation method to obtain the crystal, then the crystal is crushed, and the powder is sieved with a 100-120-mesh sieve to obtain the component 1 for later use. The traditional Chinese medicine buccal tablet is capable of soothing the liver and promoting the circulation of qi, removing blood stasis and eliminating stagnation, regulating the flow of qi and strengthening the spleen as well as tonifying the kidneys and moistening the lung, is capable of treating both symptoms and root causes, is convenient to use and can directly act on the focus.

Description

The Chinese medicinal preparation method for the treatment of chronic pharyngitis and buccal tablet thereof

Technical field

The present invention relates to containing the pharmaceutical product deriving from plant, animal or mineral component, particularly to a kind of Traditional Chinese medicine lozenge treating chronic pharyngitis and preparation method thereof.

Background technology

Chronic pharyngitis, belongs to the traditional Chinese medical science " chronic throat obstruction, chronic pharyngitis " category.Because of hub cavity on throat, lower even lung stomach, is again the communications centre of running course of channel, in close relations with the vital organs of the human body by the contact of meridians, constitutes throat and interdepends in terms of physiology with internal organs, interactional whole relation in terms of pathological change.

It is considered that its paathogenic factor can be summarized as heresy, void, the stasis of blood three kinds, it is possessed based on ailment said due to cold or exposure, pathogenic fire.And pathogenic fire have excess-fire, asthenic fire point.Empty based on the deficiency of YIN, the deficiency of vital energy.The stasis of blood is based on the stagnation of QI, expectorant knot, blood stasis.Pathogenesis shows as heresy, void, the stasis of blood three heresy mingle, so that disorder of QI movement, qi depression to blood stasis, expectorant coagulates fire stagnation, sends out and is disease ....When patients with chronic pharyngitis is gone to a doctor, the usually pharyngeal discomfort of main suit, itching throat cough, pharyngeal if any thing resistance, that tells does not goes out, and can not swallow, and the most frequently sends the sound of " noise made in coughing or vomiting of uttering a sound or a word ".Here it is the disease of the traditional Chinese medical science referred to as " chronic throat obstruction, chronic pharyngitis ".This disease mostly occurs in middle age, and the course of disease is long, and symptom is more, recurrent exerbation, is difficult to cure.

The traditional Chinese medical science thinks the door that throat is lung stomach, if any accumulated heat in the lung and stomach, and burning hot upper inflammation, stifling throat；Or because of deficiency of kidney-YIN, hyperactivity of deficient fire, decoct the body fluid that burns, all can cause pharyngeal chronic congestion, mucosa is dried, and throat loses supports and fall ill.Chronic pharyngitis is often belonged to motherland's medical science " hypopyretic laryngalgia " category by ancient Chinese medicine doctor, it is believed that internal organs are deficient, and consumption impairment of YIN is divided, hyperactivity of deficient fire causes in throat, or because of acute pharyngitis due to wind-heat recurrent exerbation, remaining evil delay, or dust foul smell stimulates, hobby tobacco and wine are pungent, and impairment caused by overstrain excessively etc. causes.Deficiency of lung-YIN then deficiency of body fluid, throat loses in moistening foster, and furthermore asthenic fire is followed through upper inflammation；Deficiency of the kidney yin, on the passages through which vital energy circulates of kidney, network is in lung, and deficiency of the kidney yin often causes the lung also deficiency of YIN, and hyperactivity of deficient fire, then to sore throat.Clinic shows themselves in that pharyngeal discomfort, bitterly gesture are indistinct more, has foreign body sensation, and night, more so the micro-redness of pharyngeal cavity was swollen, and viscous amount of expectoration is few, and weary Tianjin is dried, the few expectorant of dry cough, soreness of the waist and knees, feverish sensation in the palms and soles；The few tongue of red tongue, thready and rapid pulse.Atrophic pharyngitis described in doctor trained in Western medicine and pharyngitis sicca i.e. YIN-deficiency type of the lung and kidney, this kind of deficiency of YIN is heavier.This type of patient has endocrine disturbance, autonomic nervous dysfunction more.Control suitable nourishing YIN to lower pathogenic fire, moisturize sore-throat relieving.

Chronic pharyngitis can be individually present, it is possible to is secondary to other the most general diseases of position inflammation of upper respiratory tract.Chronic pharyngitis is controlled not in time, also can cause general malaise, even hoarseness.Therefore must promptly treat.The traditional Chinese medical science can be divided into accumulated heat in the lung and stomach, phlegm stagnation heat, YIN-deficiency of the lung and kidney etc. dissimilar according to its clinical manifestation.

Chronic simple pharyngitis can be alleviated until curing after controlling various paathogenic factors, keeping good living habit and apply various treatment, otherwise delay may become chronic hypertrophic pharyngitis；The therapeutic effect of chronic hypertrophic pharyngitis and atrophic or chronic pharyngitis sicca is not good enough, and symptom is the most repeatedly；After chronic anaphylaxis pharyngitis departs from sensitinogen, symptom can be alleviated to disappearance；After chronic reflux pharyngitis controls gastroesophageal reflux, symptom can substantially be alleviated until curing.

Summary of the invention

The technical problem to be solved is, chronic pharyngitis clinic shows themselves in that pharyngeal discomfort, bitterly gesture are indistinct more, has foreign body sensation, and night, more so the micro-redness of pharyngeal cavity was swollen, and viscous amount of expectoration is few, and weary Tianjin is dried, the few expectorant of dry cough, soreness of the waist and knees, feverish sensation in the palms and soles；The few tongue of red tongue, thready and rapid pulse.Doctor trained in Western medicine typically solves with chemicals, though there being certain curative effect, and instant effect, but easily have side effect in various degree or cause some complication；Chinese medicine product then because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical efficacy is good and enjoys favor.But existing prescription specific aim is poor, it is impossible to fundamentally alleviate the symptom of chronic pharyngitis, and the most certain side effect.Therefore, find the Traditional Chinese medicine lozenge of a kind of highly effective and safe and can go directly focus, become the urgent needs of people.

nullFor solving these technical barriers，The invention provides a kind of Traditional Chinese medicine lozenge treating chronic pharyngitis，Its described Traditional Chinese medicine lozenge can include the crude drug of following parts by weight: Cortex Moutan 10～20 parts，Exocarpium Citri Rubrum 10～20 parts，Caulis Perillae 10～20 parts，Fructus Gardeniae 10～20 parts，Radix Platycodonis 10～20 parts，Semen Oroxyli 10～20 parts，Bulbus Fritillariae Thunbergii 10～20 parts，Radix Puerariae 10～20 parts，Folium Eriobotryae 10～20 parts，Herba Andrographis 10～20 parts，Rhizoma Belamcandae 10～20 parts，Radix Scutellariae 10～20 parts，Fructus Forsythiae 10～20 parts，Flos Lonicerae 10～20 parts，Watermelon crystal 10～20 parts，The Radix Angelicae Dahuricae 10～20 parts，The Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts，Herba Menthae 10～20 parts，Borneolum Syntheticum 10～20 parts，Bombyx Batryticatus 10～20 parts，Fructus Momordicae 10～20 parts，Rhizoma Et Radix Notopterygii 10～20 parts，Indigo Naturalis 10～20 parts.

The Traditional Chinese medicine lozenge of described treatment chronic pharyngitis, its described Traditional Chinese medicine lozenge can also include the crude drug of following parts by weight: Cortex Moutan 10～15 parts, Exocarpium Citri Rubrum 10～15 parts, Caulis Perillae 10～15 parts, Fructus Gardeniae 10～15 parts, Radix Platycodonis 10～15 parts, Semen Oroxyli 10～15 parts, Bulbus Fritillariae Thunbergii 10～15 parts, Radix Puerariae 10～15 parts, Folium Eriobotryae 10～15 parts, Herba Andrographis 10～15 parts, Rhizoma Belamcandae 10～15 parts, Radix Scutellariae 10～15 parts, Fructus Forsythiae 10～20 parts, Flos Lonicerae 10～20 parts, watermelon crystal 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Menthae 10～20 parts, Borneolum Syntheticum 10～20 parts, Bombyx Batryticatus 10～20 parts, Fructus Momordicae 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Indigo Naturalis 10～20 parts.

The Traditional Chinese medicine lozenge of described treatment chronic pharyngitis, its described Traditional Chinese medicine lozenge can also include the crude drug of following parts by weight: Cortex Moutan 10～20 parts, Exocarpium Citri Rubrum 10～20 parts, Caulis Perillae 10～20 parts, Fructus Gardeniae 10～20 parts, Radix Platycodonis 10～20 parts, Semen Oroxyli 10～20 parts, Bulbus Fritillariae Thunbergii 10～20 parts, Radix Puerariae 10～20 parts, Folium Eriobotryae 10～20 parts, Herba Andrographis 10～20 parts, Rhizoma Belamcandae 10～20 parts, Radix Scutellariae 10～20 parts, Fructus Forsythiae 10～15 parts, Flos Lonicerae 10～15 parts, watermelon crystal 10～15 parts, the Radix Angelicae Dahuricae 10～15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 parts, Herba Menthae 10～15 parts, Borneolum Syntheticum 10～15 parts, Bombyx Batryticatus 10～15 parts, Fructus Momordicae 10～15 parts, Rhizoma Et Radix Notopterygii 10～15 parts, Indigo Naturalis 10～15 parts.

For solving above-mentioned technical problem, the present invention also provides for a kind of preparation method treating chronic pharyngitis Traditional Chinese medicine lozenge, and its described process for preparing buccal lozenge comprises the following steps:

A. take the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Borneolum Syntheticum and the Rhizoma Et Radix Notopterygii way of distillation and be vaporized into crystallization, as component 1；

B. remaining raw material is extracted except watermelon crystal external ethanol, as component 2；

C. by stripped for ethanol medicinal residues soak by water 2 times, concentrated extracting solution is merged, as component 3；

D. after component 2 and component 3 being mixed, concentrate, then watermelon crystal and component 1 are added mediation, sterilization, add fructose or sweeting agent makes tablet buccal tablet.

In described step a, first the crude drug Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Borneolum Syntheticum and Rhizoma Et Radix Notopterygii steam method can be distilled, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1.

In described step b, can remove the surplus stock chopping beyond watermelon crystal, be soaked and be placed in lid stainless steel cask, add 70% ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow per minute 2～3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container；Being merged by percolate and stand, stand for standby use, as component 2.

In described step c, can above-mentioned stripped raw material residue be put in 10 times amount water, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, take supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 3.

In described step c, component 2 can be merged with component 3, put in economic benefits and social benefits vacuum concentrator and mix, first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml extractum Han 0.1g, then adds component 1 and watermelon crystal, is in harmonious proportion, and sterilization adds fructose or sweeting agent makes tablet buccal tablet.

For solving above-mentioned technical problem, the present invention reoffers a kind of preparation method treating chronic pharyngitis Traditional Chinese medicine lozenge, and described Traditional Chinese medicine lozenge its preparation method can also be:

A. take the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Borneolum Syntheticum and the Rhizoma Et Radix Notopterygii way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 1；

B. by surplus stock except watermelon crystal external ethanol extraction, concentrate, as component 2；

C. sterilize after watermelon crystal being mixed with component 1 component 2, add fructose or sweeting agent makes tablet buccal tablet.

In described step b, can soak putting in 10 times amount ethanol except the surplus stock medicine of watermelon crystal 1-2 hour, heating extraction 2 times, 1-2 hour every time, taking supernatant, united extraction liquid, 100-120 mesh filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming again, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component, as component 2.

Chronic pharyngitis is a kind of commonly encountered diseases, and chronic pharyngitis is more common in adult, and child also may occur in which.General Symptoms is the most inconspicuous, based on local symptom.Various chronic pharyngitis symptom is substantially similar and varied, as pharyngeal sense of discomfort, foreign body sensation, pharyngeal secretions be difficult to bring up, pharyngeal gargalesthesia, burn feeling, dry sensation or excitement, also can have hypodynia sense.Doctor trained in Western medicine typically solves with chemicals, though there being certain curative effect, and instant effect, but easily have side effect in various degree or cause some complication；Chinese medicine product then because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical efficacy is good and enjoys favor.The present invention goes directly focus, acts at sufferer, and effect is striking.Radix Curcumae, Caulis Perillae, Exocarpium Citri Rubrum dispersing the stagnated live-QI to relieve the stagnation of QI in side, relieving distension by promoting circulation of QI, drying dampness to eliminate phlegm, regulating qi-flowing for strengthening spleen, with the trouble of eliminating phlegm-retention condensation；Folium Eriobotryae, Radix Scutellariae clearing away lung-heat and moistening for dryness, preventing phlegm from forming and stopping coughing, purge heat pathogenic fire reducing, with the lung-fire of the clear part of the body cavity above the diaphragm housing the heart and lungs；Rhizoma Belamcandae kidney tonifying yin nourishing, alleviating distention in middle-JIAO regulates the flow of vital energy, the raw gold of lung moistening, with mutual generation between metal and water, is linked up up and down by lung kidney；Cortex Moutan, Bulbus Fritillariae Thunbergii blood circulation promoting and blood stasis dispelling, relieving restlessness calms the nerves, heat clearing away eliminating stagnation, with stasis in the pharynx that disappears；Rhizoma Belamcandae, Fructus Gardeniae, the Bombyx Batryticatus pharyngeal follicle hypertrophy of dissipation；Radix Platycodonis, Semen Oroxyli, mint phlegm and relieving cough, lung qi dispersing sore-throat relieving, with the up throat of priming.Entirely can soothing the liver circulation of qi promoting, eliminating stasis and resolving masses, regulating qi-flowing for strengthening spleen, kidney tonifying lung moistening, so, then treating both the principal and secondary aspects of a disease, therefore clinical with it, control repeatly and imitate repeatly, this product is easy to carry, uses simple, and focus of going directly is the thing of the indispensability travelled in house.

Detailed description of the invention

Chronic pharyngitis is for swallowing under mucosa, mucosa and adenoid chronic inflammatory disease.Diffusivity pharyngeal inflammation is often a part for upper respiratory tract chronic inflammatory disease；Limitation pharyngeal inflammation mostly then is pharynx lymphoid tissue inflammation.Primary disease is common in clinic, and the course of disease is long, the easy recurrent exerbation of symptom.From pathology, chronic pharyngitis can be divided into following 5 classes:

1. chronic simple pharyngitis

This type more typically, shows as pharyngeal mucosa chronic congestion.Pathological changes is concentrated mainly on pharyngeal mucous layer, has more lymphoid tissue to infiltrate, it is possible to see leukocyte and plasmocyte infiltrating around its blood vessel.Connective tissue proliferation under mucosa and mucosa, can be loose with mucous gland, and glandular secretion hyperfunctioning, mucilage secretion increases and more sticky.

2. chronic hypertrophic pharyngitis

Also known as chronic particulate-pharyngitis and lateral pharyngitis, chronic simple pharyngitis protracted course of disease can form chronic hypertrophic pharyngitis, and this type is the most common in clinic.Pharyngeal mucous layer hyperemia thickens, connective tissue and lymphadenosis widely is had under mucosa and mucosa, the lymphadenosis projection around mucous gland, performance pharynx rear wall multiple graininess lymph follicle, also can combine together by multiple lymph follicles in chronic congestion shape.Inflammatory exudate in mucous gland can be closed wherein, forms cryptomere white point, visible yellow-white exudate during ulceration at the top of lymph granule protuberance.This kind of chronic pharyngitis often involves lateral pharyngeal band lymphoid tissue so that it is hypertrophy is plump, in streak.

3. atrophic and pharyngitis sicca

In clinic more rare.Their early stage mucous gland secretion reduce, secretions stiff and be dried.Continue because of Submucosa chronic inflammatory disease, gradually send out vitalization and contraction, compressing body of gland and blood vessel, make glandular secretion minimizing and malnutrition, cause the gradually atrophy of mucosa and Submucosa thinning.Can there be dry crusts or pus crusts attachment on pharynx rear wall, generally entail stink.

4. chronic anaphylaxis pharyngitis

Also known as chronic allergia pharyngitis.For betiding the I allergic reaction type mediated by IgE of pharyngeal mucosa.Allergen stimulates pharyngeal mucosa, makes the plasma cell of synthesis IgM be converted into the plasma cell of synthesis IgE, and IgE is attached to again mastocyte, basophil cellular surface, makes pharyngeal mucosa be in sensitization.After identical allergen contacts body again, allergen is combined with the IgE of medium cell surface, cause medium cell degranulation, release includes the multiple inflammatory mediator such as histamine, synthesis of prostaglandins, telangiectasis, vascular permeability increase, glandular secretion can be caused to increase, cause allergic reaction.And related allergy is former is mainly caused allergic reaction by Complement C_3, C4 approach.Chronic anaphylaxis pharyngitis occurs together in whole body allergic disease or allergic rhinitis more, also can individually fall ill.Seasonal chronic anaphylaxis pharyngitis, its symptom can have seasonal variety.As to food anaphylaxis, the related symptoms of chronic pharyngitis can occur on the feed after sensitization food.

5. chronic reflux pharyngitis

Relevant to gastroesophageal reflux.Gastric juice due to the pharyngeal mucosa of gastroesophageal reflux coup injury or causes the chronic inflammatory disease under pharyngeal mucosa and mucosa by neural reflex.

Chronic pharyngitis is more common in adult, and child also may occur in which.General Symptoms is the most inconspicuous, based on local symptom.Various chronic pharyngitis symptom is substantially similar and varied, as pharyngeal sense of discomfort, foreign body sensation, pharyngeal secretions be difficult to bring up, pharyngeal gargalesthesia, burn feeling, dry sensation or excitement, also can have hypodynia sense.Owing to pharynx rear wall generally causes more sticky secretions to adhere to because of pharyngeal chronic inflammatory disease, and owing to nose, nasal sinuses, nasopharynx pathological changes cause mouth breathing at night, irritable cough occurs when Chang Chen rises and feels sick.Owing to foreign body in pharynx sense can behave as frequently swallowing.Pharyngeal secretions is few and is difficult to expectoration person and often shows as habitually dry cough and expectoration action of clearing one's throat, and can cause pharyngeal mucosa hemorrhage if firmly coughing or clearing one's throat, cause band blood in secretions.

Radix Curcumae, Caulis Perillae, Exocarpium Citri Rubrum dispersing the stagnated live-QI to relieve the stagnation of QI in side, relieving distension by promoting circulation of QI, drying dampness to eliminate phlegm, regulating qi-flowing for strengthening spleen, with the trouble of eliminating phlegm-retention condensation；Folium Eriobotryae, Radix Scutellariae clearing away lung-heat and moistening for dryness, preventing phlegm from forming and stopping coughing, purge heat pathogenic fire reducing, with the lung-fire of the clear part of the body cavity above the diaphragm housing the heart and lungs；Rhizoma Belamcandae kidney tonifying yin nourishing, alleviating distention in middle-JIAO regulates the flow of vital energy, the raw gold of lung moistening, with mutual generation between metal and water, is linked up up and down by lung kidney；Cortex Moutan, Bulbus Fritillariae Thunbergii blood circulation promoting and blood stasis dispelling, relieving restlessness calms the nerves, heat clearing away eliminating stagnation, with stasis in the pharynx that disappears；Rhizoma Belamcandae, Fructus Gardeniae, the Bombyx Batryticatus pharyngeal follicle hypertrophy of dissipation；Radix Platycodonis, Semen Oroxyli, mint phlegm and relieving cough, lung qi dispersing sore-throat relieving, with the up throat of priming.Entirely can soothing the liver circulation of qi promoting, eliminating stasis and resolving masses, regulating qi-flowing for strengthening spleen, kidney tonifying lung moistening, so, then treating both the principal and secondary aspects of a disease, therefore clinical with it, control repeatly and imitate repeatly.

Pseudobulbus Bletillae (Rhizoma Bletillae) property is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin；Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "；Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Folium Eriobotryae all can be gathered the whole year.Its cold nature, bitter in the mouth, have effect of clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI, is usually used in treating cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastric heat vomiting, the diseases such as dysphoria with smothery sensation is thirsty.Clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.Cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastropyretic vomiting, hiccup.Xerostomia can be treated quench one's thirst, lung-wind syndrome acne vulgaris, acne." not Lu ": " main soldier is more than, the therapeutic method to keep the adverse QI flowing downwards." " Treatise on Dietetic Therapy ": " liquor is drunk, main thirsty disease, controls lung qi cough due to heat and lung-wind syndrome skin ulcer, skin ulcer on breast, face." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cough-relieving is coughed, and sputum eliminating to stop asthma, can break expectorant silk, changes pertinacious phlegm, dissipates to shout and breathes heavily, only tachypnea.″

Rhizoma Et Radix Notopterygii, another name Qiang is blue or green, protect Qiang envoy, recklessly king envoy, Qiang is sliding, move back wind envoy, black powder, Latin literary fame Notopterygium incisum. Umbelliferae, Notopterygium plant, and Chinese medicine cures mainly: warm in nature, dispelling cold and dampness, for affection of exogenous wind-cold, have a headache lossless, cold-damp numbness, upper limb rheumatalgia.Dissipate exterior cold；Wind-damp dispelling；Profit joint；Pain relieving.Main affection of exogenous wind-cold；Have a headache lossless；Edema due to wind pathogen edema；Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea；External curing vitiligo, alopecia areata.Relieving exterior syndrome and dispelling cold, expelling wind and dampness, pain relieving.Property of medicine opinion ": " control harmful wind, aphonia in silence, blood leprosy of itching more, hands and feet caused by paralysis, the askew heresy of actinal surface, insensitive impediment all over." " Japan hanako materia medica ": " controls a wind cutting gas, muscles and bones fist contraction, and extremity are thin bad, the head rotation red pain of eyes and fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times aqueous vapor, five kinds of strain and seven kinds of impairment, deficient cold air, joint ache, tonneau the five internal organs.″

Indigo Naturalis, Chinese medicine name.For rank of nobility dinner party section plant Acanthaceous indigo, polygonaceae plant polygonum tinctorium ait., the leaf of cruciferae isatis or the processed prepared dried powder of stem and leaf, agglomerate or granule.Tool heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, pathogenic fire purging arresting convulsion etc. acts on, the effects such as nature and flavor are salty-cold, have heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, pathogenic fire purging arresting convulsion.It is mainly used in epidemic febrile disease intenseness of heat, macule, spits blood, spits blood, pharyngalgia aphtha, pediatric epilepsy scared, and skin ulcer swells, erysipelas, snake bite and insect sting etc..Supplement to the Herbal: " removing toxic substances.Children's Dan Re, and water takes it." " Kaibao Bencao ": " all poison of drug of principal solution, infantile pyretic diseases, heating of fainting from fear, pestilent headache cold and heat, pan-fried water grinds and takes it.Also rub deposited herpes simplex, dislike the poison such as swollen, incised wound, hematochezia, Serpentis dog." " book on Chinese herbal medicine covers bamboo fish trap ": " eliminating pathogen in the liver, only spouting diarrhea, expectorant water on the diaphragm that disappears, drive epidemic disease headache, hold back the red speckle of typhoid fever, and water is taken after mixing with liquid it.”

Radix Puerariae, Chinese medicine name.For the dry root of legume pueraria lobata, practise and claim Herba Gelsemii Elegantis.Autumn, season in winter two excavate, and take advantage of fresh-cut and become sheet or fritter；It is dried.Sweet, pungent, cool.There are expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the merit of yang invigorating antidiarrheal.Being usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.

Fructus Forsythiae is bitter, cool.Enter the heart, liver, gallbladder meridian.Function cures mainly heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction." herbal classic ": main cold and heat, Mus flaccidity, scrofula, carbuncle malignant boil, goiter, stagnation of pathogenic heat.

Cortex Moutan, has another name called Cortex Moutan, Chinese medicine name.It is dried root bark for ranunculaceae peony.Originate in the ground such as Anhui, Shandong.Excavate root autumn, remove radicula, strip root bark, dry.Life is used or is fried and uses.Compendium of Material Medica: " nourishing YIN to lower pathogenic fire solves speckle poison, throat, diuresis stasis.Descendant is specially to control fire mutually with yellow tiller, does not knows that the merit of Cortex Moutan more wins also.Red colored person profit, the person of spending in vain mends, and people the most seldom realizes, and preferably distinguishes it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action；The methanolic extract of Cortex Moutan has suppression Platelet；Paeonol has the effects such as central inhibitory action and atherosclerosis, diuresis, antiulcer such as calmness, cooling, antipyretic, analgesia, spasmolytic.

Its root of Radix Platycodonis can be used as medicine, and has the effects such as eliminating phlegm and stopping cough, lung qi dispersing, evacuation of pus, traditional Chinese medical science common medicine.Often pickled in Northeast Area of China as brined vegetable, be used in the Korea peninsula make Pickles.Lung qi dispersing, sore-throat relieving, eliminate the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection pus becomes.Antiinflammatory action: thick kikyosaponin has antiinflammatory action, the dosage gavaging 1/10～1/5 median lethal dose(LD 50) all has antiphlogistic effects to rat hindlimb chondrus ocellatus Holmes colloidality swelling of the feet and acetic acid swelling.Gavage, less than the dosage of 1/10 median lethal dose(LD 50), every day 1 time, successive administration, also has significant inhibitory action to rat granuloma is swollen, and the most effective to rat assist agent arthritis.This kind of preparation can also reduce anaphylaxis, the capillary permeability of mice.The mouse writhing that lumbar injection kikyosaponin causes reacts and Abdominal effusion, and the same Saponin of gavage can produce suppression.Radix Platycodonis is without direct antibacterial action, but its water extract can strengthen macrophage phagocytic function, strengthens the sterilizing power of neutrophilic leukocyte.Improve the activity of lysozyme.

Fructus Gardeniae (formal name used at school: Gardenia jasminoides Ellis) is called: Yellow Fructus Gardeniae, Fructus Gardeniae, white toad, be the fruit of Maguireothamnus speciosus Fructus Gardeniae.The fruit of Fructus Gardeniae is Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, have hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, stop blooding, the effect such as detumescence.It is usually used in treating the diseases such as icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.

Radix Glycyrrhizae is used for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc..The former, normal and Ramulus Cinnamomi compatibility, such as Ramuli Cinnamomi and Glycyrrhizae Decoction, zhigancao decoction.The latter, is often equal to use with Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, such as ball etc. in decoction of four noble drugs, reason.For ulcer sores, laryngopharynx swelling and pain etc..Can be alone, for oral administration or external application, or compatibility application.Ulcer sores, is often equal to use with Flos Lonicerae, Fructus Forsythiae, plays the merit of heat-clearing and toxic substances removing altogether, such as Xian fang Huoming Yin.Laryngopharynx swelling and pain, the normal and same use of Radix Platycodonis, such as Radix Platycodonis decoction.If pesticide, alimentary toxicosis, often join Semen phaseoli radiati or be decocted in water for oral dose with Radix Saposhnikoviae.For asthma and cough.Can be alone, also can the application of compatibility other drug.As controlled the ERCHEN TANG of cough due to damp-phlegm；Control the Linggan Wuwei Jiangxin Tang of cold-phlegm cough with asthma；Control the sangxing decoction of dry stool phlegm cough；Control pyretic toxicity and cause lung abscess cough and spit and smell as of rotten fish the Radix Platycodonis decoction of purulent sputum；Control the Gancao Ganjiang soup etc. of cough and spit saliva foam.Another cough due to pathogenic wind-heat, cough due to wind and cold, phlegm heat cough also Chang Peiwu application.For having a stomachache, suffer from abdominal pain and gastrocnemius contraction urgency pain etc..For being in harmonious proportion the strong of some drugs.As seasoning CHENGQI TANG this product relaxes Radix Et Rhizoma Rhei, the discharge function of Natrii Sulfas and stimulates gastrointestinal.It addition, also commonly use this product coordinating the actions of various ingredients in a prescription in many prescriptions.

Semen Oroxyli sore-throat relieving lung moistening；Dispersing the stagnated liver-QI for regulating the stomach；Expelling pus and promoting granulation.Cure mainly: pharyngalgia sore throat；Hoarseness；Cough；Stomachache due to hyperactive liver-QI attacking the stomach；Skin infection is burst for a long time and is not held back；Acute eczema.Effect is classified: antitussive；The lung moistening medicine；And stomach medicine.Medical material Ji Yuan: for the mature seed of Bignoniaceae plant oroxylum indicum.Come from supplementary Amplifications of the Compendium of Materia Medica seed, peel of stem contains baicaligenin, has antiinflammatory, antiallergic action, diuresis, function of gallbladder promoting, the effect of cholesterol reducing.

Exocarpium Citri Rubrum, Chinese medicine name.For rutaceae orange Citrus reticulata Blanco and the dry outside rind of variety thereof.Gather after time of the year when autumn changes into winter fruit maturation, cut lower outer peel with cutter, dry or dry in the shade.Acrid in the mouth, hardship, warm in nature.Return lung, spleen channel.Effect regulating the flow of QI to ease the stomach, drying dampness to eliminate phlegm.Curing mainly for cough with copious phlegm, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.Compendium of Material Medica: therapeutic method to keep the adverse QI flowing downwards expectorant." herbal classic is met former ": the special main lung cold cough excessive phlegm of Exocarpium Citri Rubrum, deficient side multiplex it, right chronic cough diarrhea due to stagnation of QI, the most non-preferably." medicineization justice ": Exocarpium Citri Rubrum, pungent eliminating stagnation of walking crosswise, bitter decline of keeping straight on, for promoting the circulation of QI key medicine.Lid is controlled expectorant and must be regulated the flow of vital energy, diarrhea due to disorder of QI expectorant spontaneous recovery, therefore with entering lung spleen, all expectorant main are sick, and merit occupies on all expectorant medicines.Assistant Caulis Bambusae In Taenia to treat heat-hiccup, help Pericarpium Citri Reticulatae Viride with intestinal stasis relieving gas, real in the flat stomach of same Rhizoma Atractylodis, Cortex Magnoliae Officinalis, close the heresy that Bulbus Allii Fistulosi, Herba Ephedrae exterior cold are wet, rapid digestion of food gas, alcoholic intoxication, anti-nausea, open chest and diaphragm painful abdominal mass plug, Chen Zhixin can be pushed away, the power of the most pungent scattered hardship fall is also.

Poria sweet in the mouth, light, property is put down.GUIXIN, lung, spleen, kidney channel.Effect promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.Curing mainly for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool has loose bowels, irritability, palpitation with fear insomnia.Compendium of Material Medica: Poria abnormal smells from the patient is light and oozes, and its property is up, born fluid, loosing the interspaces of skin and muscles, grows water source and declines, diuresis, therefore Zhang Jiegu calls its genus sun, floats and rises, says its property also；Dong Yuan call its for the YIN aspect of YANG, fall and under, Yan Qigong is also.Amplification on Canon of Materia Medica: Poria, Poria cum Radix Pini, the merit of row water is many, heart-spleen boosting can not fault also.

Rhizoma Belamcandae root stock is medicinal, bitter in the mouth, poison cold in nature, micro-.Energy heat-clearing and toxic substances removing, eliminating stagnation antiinflammatory, reducing swelling and alleviating pain, relieving cough and resolving phlegm, be used for treating tonsillitis and lumbago.For experiencing wind heat, or expectorant heat stops up the diseases such as the laryngopharynx swelling and pain caused by containing.For diseases such as accumulation and obstruction of sputum, cough and asthmas.Laryngopharynx swelling and pain, sore throat is obstructed, constipation and anuresis, and all medicines are not imitated, abdominal part hydrops, skin turn black, acute mastitis from the beginning of.This product is poisonous, extracts it is noted that reduce toxicity.

Borneolum Syntheticum acrid in the mouth, hardship, be slightly cold；GUIXIN, liver, lung meridian；Delicate fragrance a surname dissipate, and has refreshment of having one's ideas straightened out, and heat clearing away dissipates poison, effect of improving acuity of vision and removing nebula, cures mainly calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, and heat-damp in summer blinds clear key, and sore throat is deaf, and aphtha tooth swells, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain, pterygium.Logical all keys, dissipate stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain, and heat clearing away dissipates poison, dissipates fire removing toxic substances.Control mammary gland caking, apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, mesh also nebula film, enterobiasis." not Lu ": " married woman has difficult labour, and takes Borneolum Syntheticum and grinds into powder a little, is taken after mixing with liquid newly to draw water." Tang Materia Medica: " main trusted subordinate pathogen, rheumatism is gathered, deaf.Improving eyesight, goes conjunctival congestion skin nebula.External oculopathy eye in " " Haiyao Bencao, Oversea Materia Medica ": " is main, three worms, control five hemorrhoid, improving eyesight, relieving palpitation, secret essence.″

Caulis Perillae, another name: Folium Perillae stem, Caulis Perillae, Folium Perillae bar.Latin literary fame Perilla frutescens (L.) Britton. is a kind of Chinese medicine title.This product is the dry stem of labiate Folium Perillae Perillafrutescens (L.) Britt..Autumn taps after fruit maturation, removes impurity, dries, or take advantage of fresh slices, dry.Folium Perillae pungent temperature row dissipates, and leaf is gently such as lung, energy dispersing wind-cold, lung qi dispersing cough-relieving；Stalk such as taste, be good at circulation of qi promoting with in, regulate the flow of vital energy antiabortive.Therefore commonly used by cough due to wind and cold, stagnation of QI in spleen and stomach, additionally, solve again the poison of fish Eriocheir sinensis.Relieving the exterior syndrome by diaphoresis (Folium Perillae is preferable): for anemofrigid cold, cough with copious phlegm.Curing mainly anemofrigid cold, aversion to cold is lossless；Wind and cold violates lung, cough with copious phlegm；Affection of exogenous wind-cold, interior double stagnation of QI person's use better.Promoting the circulation of QI to alleviate the stagnation in middle-JIAO (Caulis Perillae, Soviet Union's pocket are preferable): for stagnation of QI in spleen and stomach, vomiting uncomfortable in chest.This product is promoting the circulation of QI to alleviate the stagnation in middle-JIAO, and activating QI to stop vomiting good medicine has antiabortive merit of regulating the flow of vital energy concurrently.

Fructus Gardeniae hardship pungent, micro-, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.Curing mainly for stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea." Amplification on Materia Medica addendum ": Fructus Gardeniae, must soak with urine of baby boys, and all vim and vigour medicines must cause edema caused by disorder of QI and hemopoietic with it, and the justice of this Yin grows while yang is generating is also.Zhu Zhenheng: Fructus Gardeniae, " herbal " does not say benefit, and the Fan family says in old man useful, and here meaning deposits, and is placed in row and has benefit reason.

The pungent one-tenth of Bombyx Batryticatus is flat.Enter liver, lung, stomach warp.Function cures mainly expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Control apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble.Sore throat, scrofula tuberculosis.Wind skin ulcer urticaria, erysipelas, mastitis." herbal classic ": main pediatric epilepsy scared night cry, goes three worms, goes out black, and man's the moon infections is sick." not Lu ": woman's metrorrhagia is red in vain, puerperal remaining pain, all skin ulcer cicatrixs of going out.

Fructus Momordicae, the fruit of the perennial liana of Cucurbitaceae.Fruits nutrition is worth the highest, containing abundant vitamin C (containing 400 milligrams～500 milligrams in every 100 grams of fresh fruits) and glucoside, fructose, glucose, protein, lipid etc..Fructus Momordicae sweet in the mouth is cool in nature, returns lung, large intestine channel, has nourishing the lung to arrest cough, effect of promoting the production of body fluid to quench thirst, is applicable to lung-heat or xeropulmonary cough, pertussis and summer-heat impairment of body fluid are thirsty etc., in addition with effect of loosening bowel to relieve constipation.

Herba Menthae is one of China's conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc..Usually with Herba Menthae for tea, clear away heart-fire improving eyesight.

The root of Radix Scutellariae is used as medicine, bitter in the mouth, cold in nature, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical antibiotic property of Radix Scutellariae is better than Rhizoma Coptidis, and does not develops immunity to drugs.

Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and do not injure one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, be also apt to removing summer-heat blood poison, for various febrile diseases, such as fever of the body, dermexanthesis, send out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal effect is notable.

Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Uninbracteatae, river person's sweet in the mouth is optimal: western person's taste is thin to take second place, and the micro-hardship of Xiangshan person is taken second place again, and one is big and hardship person is only capable of removing toxic substances.And go the heart to use.All lung meridian medicines are all when removing the heart, and not only Bulbus Fritillariae Uninbracteatae is also.Successive dynasties document in the past, the special bar of the most discrete Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii, Rhizoma Bolbostematis, after starting from Bulbus Fritillariae Uninbracteatae bar to bright " book on Chinese herbal medicine is just ", Li not go up Bulbus Fritillariae Uninbracteatae one, indication is i.e. this product.Removing heat-phlegm, powder detoxifcation.Control cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin." book on Chinese herbal medicine is just ": " control greatly lung abscess lung to wither, cough with asthma, spit blood, epistaxis, most mental disorder drops, and kind relieving stagnation, relieve the pain pain, and relieving distension is full, clearing away liver-fire, bright knowledge, except seasonal epidemic pathogens dysphoria with smothery sensation, jaundice stranguria with urinary obstruction, hematuria of having blood in stool；Relieving heat toxin, kills parasites and treats sore throat, scrofula, acute mastitis carbuncle on the back, all carbuncle and ulcer toxic swellings, damp and hot malignant boil, anal fistula, and incised wound is hemorrhage, burn pain, and than Bulbus Fritillariae Cirrhosae, the merit of clear fall, not less than several times.

Herba Andrographis has eliminating inflammation and expelling toxin effect, the most once multi-infection disease it was applied to, including trauma infection contamination, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infection, endometritis, pelvic inflammatory disease, otitis media, periodontitis etc., all there is curative effect in various degree.

Specific embodiment 1

The preparation of buccal tablet of the present invention:

nullBy Radix Angelicae Dahuricae 1200g、Pseudobulbus Bletillae (Rhizoma Bletillae) 1400g、Herba Menthae 1300g、Borneolum Syntheticum 1200g and the Rhizoma Et Radix Notopterygii 1200g way of distillation are vaporized into crystallization，Pulverize stand-by，For component 1，Again by Cortex Moutan 1200g，Exocarpium Citri Rubrum 1300g，Caulis Perillae 1200g，Fructus Gardeniae 1200g，Radix Platycodonis 1100g，Semen Oroxyli 1200g，Bulbus Fritillariae Thunbergii 1300g，Radix Puerariae 1200g，Folium Eriobotryae 1100g，Herba Andrographis 1200g，Rhizoma Belamcandae 1100g，Radix Scutellariae 1100g，Fructus Forsythiae 1200g，Flos Lonicerae 1200g，Bombyx Batryticatus 1200g，Fructus Momordicae 1200g，Indigo Naturalis 1200g，Add soak with ethanol 2-3 hour accounting for its quality 7-10 times，Heating extraction 2 times，1-2 hour every time，United extraction liquid，Supernatant is taken after standing，Then 100-120 mesh filters，The ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming again，The filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C.The medicinal residues of the crude drug crossed by above-mentioned ethanol extraction again add 10 times amount water, heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged and stands, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, mix two kinds and extract filtrate, as component 2, being put in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g, adds component 1 and watermelon crystal 1200g, sterilization, adds fructose or sweeting agent makes tablet buccal tablet.

Specific embodiment 2

nullBy Radix Angelicae Dahuricae 1200g、Pseudobulbus Bletillae (Rhizoma Bletillae) 1300g、Herba Menthae 1300g、Borneolum Syntheticum 1200g and the Rhizoma Et Radix Notopterygii 1200g way of distillation are vaporized into crystallization，Pulverize stand-by，For component 1，Again by Cortex Moutan 1200g，Exocarpium Citri Rubrum 1300g，Caulis Perillae 1200g，Fructus Gardeniae 1200g，Radix Platycodonis 1100g，Semen Oroxyli 1200g，Bulbus Fritillariae Thunbergii 1300g，Radix Puerariae 1200g，Folium Eriobotryae 1100g，Herba Andrographis 1200g，Rhizoma Belamcandae 1100g，Radix Scutellariae 1100g，Fructus Forsythiae 1200g，Flos Lonicerae 1200g，Bombyx Batryticatus 1200g，Fructus Momordicae 1200g，The chopping of Indigo Naturalis 1200g is soaked to be placed in lid stainless steel cask，Add 70% ethanol，Quality is coarse grained 0.8-1 times，Stir，Moistening airtight placement more than 1 hour，Make fully to expand；By bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow per minute 2～3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container；Being merged by percolate and stand, stand for standby use, as component 2；Again stripped raw material residue is put in 10 times amount water, soak 1-2 hour, heating extraction 2 times, 1-2 hour every time, take supernatant, united extraction liquid, 100-120 mesh filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming again, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 3, component 2 is merged with component 3, putting in economic benefits and social benefits vacuum concentrator and mix, first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml extractum Han 0.1g, then adds component 1 and watermelon crystal, is in harmonious proportion, and sterilization adds fructose or sweeting agent makes tablet buccal tablet.

Specific embodiment 3

By Radix Angelicae Dahuricae 1200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1300g, Herba Menthae 1300g, Borneolum Syntheticum 1200g and the Rhizoma Et Radix Notopterygii 1200g way of distillation are vaporized into crystallization, pulverize stand-by, for component 1, again by Cortex Moutan 1200g, Exocarpium Citri Rubrum 1300g, Caulis Perillae 1200g, Fructus Gardeniae 1200g, Radix Platycodonis 1100g, Semen Oroxyli 1200g, Bulbus Fritillariae Thunbergii 1300g, Radix Puerariae 1200g, Folium Eriobotryae 1100g, Herba Andrographis 1200g, Rhizoma Belamcandae 1100g, Radix Scutellariae 1100g, Fructus Forsythiae 1200g, Flos Lonicerae 1200g, Bombyx Batryticatus 1200g, Fructus Momordicae 1200g, Indigo Naturalis 1200g chopping soak with ethanol, heated and boiled 3 times, 1-2 hour every time, filter, filtrate is standby；By in the filtrate suction concentrating under reduced pressure tank merging latter 3 times, being evaporated to relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C；Become component 2, blending ingredients 1 and component 2, then add watermelon crystal 1000g, sterilization, add fructose or sweeting agent makes tablet buccal tablet.

Toxicology test:

Test example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 20-23g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention sucks agent.

Two, method:

1, LD50 calculates: use improvement karber's method, mice is randomly divided into 5 groups, often group 10, male and female half and half, dissolve suppository, are made into Cmax, being administered by the maximum allowable capacity of mice, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), after animal fasting (can't help water) 18 hours, it is administered (interval half an hour), each 0.5ml in one day at twice, treats animal dead situation.

2, maximum tolerated dose measures (MTD value): take mice 20, each 10 of male and female.Suppository adds distilled water dissolve, be made into maximum concentration, by the maximum tolerated dose of animal, can twitch with injection filling hello device and be as the criterion.After animal fasting (can't help water) 18 hours, (interval half an hour) it is administered at twice in one day, 0.5ml (every ml 0.36g Han crude drug) every time, total dose is 18g crude drug/kg.d, 300 times of quite clinical adult's 50Kg body weight consumption.Treat 7 days continuously after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum allowable capacity (18g/Kg.d), have no dead mouse, i.e. do not measure LD50, seek maximum tolerated dose only, interim treatment in 7 days, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.I.e. select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD ＞ 18g/Kg.d.

Test example 2: acute skin irritation test of the present invention is reported

1, experiment purpose: the detection present invention sucks agent to the stimulation/corrosiveness of laboratory animal skin and intensity

2, material and method:

2.1. tested material: title: the present invention sucks agent (embodiment 2 method prepares)

2.2. laboratory animal: one grade of big ear white race rabbit, 10, female, body weight 2.2-2.4kg；Thered is provided by Affiliated Hospital of Qingdao University biology department Experimental Animal Center；

2.3. test method:

Select the healthy rabbits 10 that skin is intact, its spinal column both sides, back were cut by hair in first 24 hours in test, remove the left and right each about 4cm × 4cm of gross area.Taking tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm × 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.After closing 4 hours, dismantling, and go to remain tested material with warm water cleaning, position dermoreaction is smeared in the treatments in 1,24 and 48 hours after removing tested material, and marks.

3, experimental result: any erythema does not occurs in laboratory animal skin, red and swollen, inflammation phenomenon.

4, brief summary: judging according to skin wound repair standards of grading in " disinfection technology standard " (1999), the present invention belongs to nonirritant to animal skin stimulus intensity.

Pharmacological experiment

Chronic pharyngitis is common clinical, frequently-occurring disease, how by the chronic inflammatory disease in acute pharyngitis recurrent exerbation, adjacent tissue, or is induced by pessimal stimulations such as cigarette, wine, climatic factor, and digestive disorders for a long time；Clinical with pharyngalgia, itching throat, hawk cough, and foreign body in pharynx sense is main performance.This disease often makes patient's feelings will not relax, state of an illness performance multiterminal, and recurrent exerbation, touching difficulty more, is treated the most thorny.Chronic pharyngitis refers to by the pharyngeal pathological changes of the diffusivity caused by chronic infection, multiple it is born in adult, it is often accompanied by other upper respiratory diseases, often stimulates pharyngeal because of the pus of acute pharyngitis recurrent exerbation, rhinitis, sinusitis, or nasal obstruction and mouth breathing etc. cause the generation of chronic pharyngitis.In Decembers, 2014～in December, 2015 use buccal tablet of the present invention treatment chronic pharyngitis 130 example, obtain good therapeutic effect, and existing report is as follows.

1 clinical data

1.1 physical data 130 examples are hospital outpatient patient, meet chronic pharyngitis diagnostic criteria, are randomly divided into 2 groups.Treatment group 65 example, age 19～65 years old.Matched group 65 example, age 19～66 years old；The equal ＞ of the course of disease 6 months.The no significant difference (P ＞ 0.05) such as 2 groups of ages, sex, state of an illness, have comparability.

1.2 diagnostic criteria

1) medical history: often have acute pharyngitis history of repeated attack, or have the long-term mouth breathing of cacorhinia, the inducement that tobacco and wine are excessively, surrounding air is dried, dust and irritative gas pollute.2) symptom: pharyngeal discomfort, or pain or itch or have dry sensation, burning sensation, sootiness sense, foreign body sensation etc.；Irritable cough, plays firmly expectoration secretions morning, even feel sick.The course of disease more than 2 months, Chang Yin suffers from cold, catches a cold, the reason such as fatigue, polylogia causes.3) checking: pharyngeal chronic congestion, increase the weight of, in kermesinus, or dendroid is congested；Retropharyneal folliculosis, or lateral pharyngeal band enlargement；Pharynx mucosa hypertrophy is plump, or be dried, atrophy, thinning, have secretions to adhere to.Possess above-mentioned symptom and 1 or more than 1 check finding, the most diagnosable.Syndrome to be met: pharyngeal dry pain is uncomfortable, burning sensation, foreign body sensation, or itching throat expectorant less, heavy towards light dusk, can check see that pharyngeal mucosa is dark red, dry with diseases such as hectic fever in the afternoon, fidgets due to deficiency insomnia, soreness of the waist and knees.Belong to YIN-deficiency type of the lung and kidney chronic pharyngitis.

2 Therapeutic Method

2.1 treatment groups employing buccal tablets of the present invention, Fang Yong: Cortex Moutan 12g, Exocarpium Citri Rubrum 11g, Caulis Perillae 13g, Fructus Gardeniae 12g, Radix Platycodonis 12g, Semen Oroxyli 13g, Bulbus Fritillariae Thunbergii 12g, Radix Puerariae 12g, Folium Eriobotryae 12g, Herba Andrographis 13g, Rhizoma Belamcandae 102g, Radix Scutellariae 12g, Fructus Forsythiae 13g, Flos Lonicerae 12g, watermelon crystal 12g, Radix Angelicae Dahuricae 12g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Herba Menthae 12g, Borneolum Syntheticum 13g, Bombyx Batryticatus 12g, Fructus Momordicae 13g, Rhizoma Et Radix Notopterygii 10g, Indigo Naturalis 10g.Be prepared as buccal tablet by embodiment 2 method, every day 5-7 sheet.

Matched group: LIUSHEN WAN (Shanghai Leiyun Pharmaceutical Industry Co., Ltd.) is administered orally, and three times a day, warm water is swallowed, grows up and often takes 10.External watermelon crystal buccal tablet (Sanjin Pharmaceutical Co., Ltd., Guilin), external is sucked, every day is for several times, gentamycin 80,000 U (Tianjin Pharmaceutical Jiaozuo Co., Ltd.) and 20mL normal saline carry out ultrasonic atomizatio (Omron nebulizer NE-c29) Inhalation in Treating, the each 20min of respiratory time, every day 1 time.All 5d are 1 course for the treatment of, continuously 3 courses for the treatment of of treatment.Observe 2 groups of patient's pharyngeal pain, silent, mucosa is dry and congestion and edema transference cure and alleviate the time.

3 criterions of therapeutical effect and result

Criterion of therapeutical effect is drafted with reference to " hals,Nasen und Ohrenheilkunde diagnostics " criterion of therapeutical effect.Treatment group 65 example, effective 40 examples, effective 17 examples, invalid 8 examples, total effective rate is 87.69%；Matched group 65 example, effective 31 examples, effective 12 examples, invalid 22 examples, total effective rate is 66.15%.2 groups of comparing differences statistically significant (P ＜ 0.05).

Chronic pharyngitis is the most multiple, and symptom stubbornness is difficult to cure.Pharyngeal sense of discomfort easily makes patient heart the best, suspicious, the state of an illness, the interaction of both moods, makes state of an illness stubbornness complicated, is also one of refractory reason.Primary disease belongs to Chinese medicine " sore throat " category.<Huang di's Canon of Medicine>is loaded with " spleen is too late, then nine orifices is different ".Holy Benevolent Prescriptions is said: " pharynx person swallows also, and sky can swallow thing, the again choke of meaning, main tonneau water paddy, the path of gastric qi." say again: " also, speech is wherein hollow, can lead in QI and blood, breathe the circulation into lung qi for throat person's inanition." " Plain Questions passages through which vital energy circulates another matter " say: " spleen-QI transporting the essence to the whole body, is above attributed to edema caused by the lung disorder essence four cloth, and the Five Classics is parallel." say again: " kidney meridian of Foot-SHAO YIN is main kidney disease of viscera connecting with this channel person, the hot dry tongue of mouth, gas on pharyngeal swelling, dry sensation in the pharynx and pain." as can be seen here, throat and lung, spleen, kidney relation are the closest.The passages through which vital energy circulates " cloth side of body rib, after following throat, above enter neck forehead " " Plain Questions QI and blood shape will " of liver is pointed out: " excessive physical exertion and mental depression, diease occurrence is in pharynx." liver controlling conveyance and dispersion, happiness bar reaches and depressed.The liver failing to maintain the normal flow of QI, depression of liver-QI, perverse and unreasonable manner criminal's spleen, insufficiency of the spleen dry phlegm-syndrome, mental disorder is handed over and is hindered in throat generation sore throat；The stagnation of QI with the passing of time, then must blood stasis, " prolonged illness must the stasis of blood ", stagnation of blood stasis be in throat, and sore throat is the most touching.Visible, feelings will Nervous and Mental Factors cause the liver failing to maintain the normal flow of QI be primary disease morbidity because of, gas, blood, expectorant, the stasis of blood are the major pathologic features of primary disease, and lung, spleen, renal function are not normal is only primary disease pathogenesis basis.The traditional Chinese medical science thinks that chronic pharyngitis is many by ferritic YIN-deficiency of the lung and kidney, or acute pharyngitis due to wind-heat recurrent exerbation, and remaining heresy is detained unclear, impairment of body fluid consumption liquid, causes consumption of YIN-fluid, and throat loses in moistening foster, furthermore disturbs in asthenic fire, sends out as primary disease.Therefore YIN-deficiency type of the lung and kidney chronic pharyngitis is more common type, its disease, pathogenesis, method for the treatment of, side's medicine are as follows.

Radix Curcumae, Caulis Perillae, Exocarpium Citri Rubrum dispersing the stagnated live-QI to relieve the stagnation of QI in side, relieving distension by promoting circulation of QI, drying dampness to eliminate phlegm, regulating qi-flowing for strengthening spleen, with the trouble of eliminating phlegm-retention condensation；Folium Eriobotryae, Radix Scutellariae clearing away lung-heat and moistening for dryness, preventing phlegm from forming and stopping coughing, purge heat pathogenic fire reducing, with the lung-fire of the clear part of the body cavity above the diaphragm housing the heart and lungs；Fructus Trichosanthis, Radix Trichosanthis kidney tonifying yin nourishing, alleviating distention in middle-JIAO regulates the flow of vital energy, the raw gold of lung moistening, with mutual generation between metal and water, is linked up up and down by lung kidney；Cortex Moutan, Bulbus Fritillariae Thunbergii blood circulation promoting and blood stasis dispelling, relieving restlessness calms the nerves, heat clearing away eliminating stagnation, with stasis in the pharynx that disappears；Rhizoma Belamcandae, Fructus Gardeniae, the Bombyx Batryticatus pharyngeal follicle hypertrophy of dissipation；Radix Platycodonis, Semen Oroxyli, mint phlegm and relieving cough, lung qi dispersing sore-throat relieving, with the up throat of priming.Entirely can soothing the liver circulation of qi promoting, eliminating stasis and resolving masses, regulating qi-flowing for strengthening spleen, kidney tonifying lung moistening, so, then treating both the principal and secondary aspects of a disease, therefore clinical with it, control repeatly and imitate repeatly.This product is easy to carry, uses simple, and focus of going directly is the thing of the indispensability of travelling at home.

Claims

1. the preparation method of the Traditional Chinese medicine lozenge treating chronic pharyngitis, it is characterised in that include following Step:

The most according to claim 1, treat the preparation method of the Traditional Chinese medicine lozenge of chronic pharyngitis, its feature exists In, in described step a, first by the crude drug Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Borneolum Syntheticum and Rhizoma Et Radix Notopterygii steam method Distillation, obtains crystal, then pulverizes, and crosses 100-120 mesh sieve, standby as component 1.

The most according to claim 1, treat the preparation method of the Traditional Chinese medicine lozenge of chronic pharyngitis, its feature exists In, in described step b, the surplus stock chopping beyond watermelon crystal will be removed, and be soaked and be placed in lid not In rust steel drum, adding 70% ethanol, quality is coarse grained 0.8-1 times, stirs, and moistens airtight putting Put more than 1 hour, make fully to expand；Filter plate gauze bag bottom percolator is wrapped up after paving again by wet Drug sample after profit expansion is mixed pine and is done to dissipate, and then with rustless steel spoon Sheng powder, loads percolator uniformly, Dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, and loading in layer, suitably pressurize, Medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens percolation Cylinder baiting valve below, and put a container, then it is slowly added into 70% ethanol；Medicated powder powder to be discharged Between air, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 little Time, then open baiting valve and carry out percolation, control percolation speed be generally 1000g medical material outflow per minute 2～ 3ml, filtrate is put into liquid container, and is poured ethanol during emptying into liquid container；Percolate is merged Standing, stand for standby use, as component 2.

The most according to claim 1, treat the preparation method of the Traditional Chinese medicine lozenge of chronic pharyngitis, its feature exists In, in described step c, above-mentioned stripped raw material residue is put in 10 times amount water, soaks 1-2 hour, Heating extraction 2 times, each 1-2 hour, takes supernatant, united extraction liquid, and 100-120 mesh filters, then warp The molecular weight that dams is the ultrafiltration post ultrafiltration of 5000-10000, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C The filtrate of 1.05, as component 3.

The most according to claim 1, treat the preparation method of the Traditional Chinese medicine lozenge of chronic pharyngitis, its feature exists In, in described step c, component 2 is merged with component 3, put in economic benefits and social benefits vacuum concentrator and mix, first Concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours； The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, dense It is reduced to every 1ml extractum Han 0.1g, then adds component 1 and watermelon crystal, be in harmonious proportion, sterilization, add fructose or sweet taste Tablet buccal tablet is made in agent.

6. the preparation method of the Traditional Chinese medicine lozenge treating chronic pharyngitis, it is characterised in that include following Step:

Treat the most according to claim 6 chronic pharyngitis Traditional Chinese medicine lozenge preparation method, its feature It is, in described step b, will put in 10 times amount ethanol except the surplus stock medicine of watermelon crystal, soak 1-2 Hour, heating extraction 2 times, each 1-2 hour, take supernatant, united extraction liquid, 100-120 mesh filters, The ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming again, ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C time 1.05 filtrate, as component, as component 2.

8. the Traditional Chinese medicine lozenge treating chronic pharyngitis, it is characterised in that include following parts by weight Crude drug: Cortex Moutan 10～20 parts, Exocarpium Citri Rubrum 10～20 parts, Caulis Perillae 10～20 parts, Fructus Gardeniae 10～20 parts, Radix Platycodonis 10～20 parts, Semen Oroxyli 10～20 parts, Bulbus Fritillariae Thunbergii 10～20 parts, Radix Puerariae 10～20 parts, Folium Eriobotryae 10～20 parts, Herba Andrographis 10～20 parts, Rhizoma Belamcandae 10～20 parts, Radix Scutellariae 10～20 parts, Fructus Forsythiae 10～20 parts, Flos Lonicerae 10～20 parts, watermelon crystal 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Menthae 10～ 20 parts, Borneolum Syntheticum 10～20 parts, Bombyx Batryticatus 10～20 parts, Fructus Momordicae 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Indigo Naturalis 10～20 parts.

Treat the Traditional Chinese medicine lozenge of chronic pharyngitis the most according to claim 8, it is characterised in that in described Medicine buccal tablet includes the crude drug of following parts by weight: Cortex Moutan 10～15 parts, Exocarpium Citri Rubrum 10～15 parts, Caulis Perillae 10～15 parts, Fructus Gardeniae 10～15 parts, Radix Platycodonis 10～15 parts, Semen Oroxyli 10～15 parts, Bulbus Fritillariae Thunbergii 10～15 Part, Radix Puerariae 10～15 parts, Folium Eriobotryae 10～15 parts, Herba Andrographis 10～15 parts, Rhizoma Belamcandae 10～15 parts, yellow A kind of reed mentioned in ancient books 10～15 parts, Fructus Forsythiae 10～20 parts, Flos Lonicerae 10～20 parts, watermelon crystal 10～20 parts, the Radix Angelicae Dahuricae 10～ 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Menthae 10～20 parts, Borneolum Syntheticum 10～20 parts, Bombyx Batryticatus 10～20 parts, sieve Chinese fruit 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Indigo Naturalis 10～20 parts.

Treat the Traditional Chinese medicine lozenge of chronic pharyngitis the most according to claim 8, it is characterised in that described Traditional Chinese medicine lozenge includes the crude drug of following parts by weight: Cortex Moutan 10～20 parts, Exocarpium Citri Rubrum 10～20 parts, Folium Perillae Obstruct 10～20 parts, Fructus Gardeniae 10～20 parts, Radix Platycodonis 10～20 parts, Semen Oroxyli 10～20 parts, Bulbus Fritillariae Thunbergii 10～ 20 parts, Radix Puerariae 10～20 parts, Folium Eriobotryae 10～20 parts, Herba Andrographis 10～20 parts, Rhizoma Belamcandae 10～20 parts, Radix Scutellariae 10～20 parts, Fructus Forsythiae 10～15 parts, Flos Lonicerae 10～15 parts, watermelon crystal 10～15 parts, the Radix Angelicae Dahuricae 10～ 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 parts, Herba Menthae 10～15 parts, Borneolum Syntheticum 10～15 parts, Bombyx Batryticatus 10～15 parts, sieve Chinese fruit 10～15 parts, Rhizoma Et Radix Notopterygii 10～15 parts, Indigo Naturalis 10～15 parts.