CN103877365A - Traditional-Chinese-medicine composition for treating diabetes - Google Patents
Traditional-Chinese-medicine composition for treating diabetes Download PDFInfo
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- CN103877365A CN103877365A CN201410152827.4A CN201410152827A CN103877365A CN 103877365 A CN103877365 A CN 103877365A CN 201410152827 A CN201410152827 A CN 201410152827A CN 103877365 A CN103877365 A CN 103877365A
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Abstract
The invention relates to a medicine for treating the diabetes and particularly relates to traditional-Chinese-medicine composition for treating the diabetes, which is prepared from Chinese herbal medicines as raw materials. The traditional-Chinese-medicine composition is characterized by comprising raw medicinal materials constituting effective ingredients in parts by weight: 5-10 parts of codonopsis pilosula, 10-20 parts of astragalus membranaceus, 10-15 parts of salvia miltiorrhiza, 5-10 parts of Chinese yam, 5-10 parts of rhizoma atractylodis macrocephalae, 5-10 parts of radix ophiopogonis, 5-10 parts of ligusticum wallichii, 10-15 parts of tortoise shell, 5-10 parts of hawthorn, 10-30 parts of mulberry twig, 20-30 parts of radix rehmanniae recen and 5-10 parts of poria cocos. The traditional-Chinese-medicine composition has the advantages that by compatibility, all the medicines bring out the best in each other, so that the effects of tonifying primordial qi, relieving desertion and engendering fluid, clearing heat and removing toxicity, dispelling wind and dredging collaterals, relieving restlessness and quenching thirst, invigorating qi for strengthening superficies, promoting urination and eliminating toxicity, benefiting the stomach and engendering fluid, promoting metabolism and controlling the body weight and the like are achieved; due to the synergistic effect of the pharmaceutical effects, the diabetes is obviously controlled, the urine sugar and the blood sugar reach to be normal, and no toxic and side effects are caused; the economical and practical effects are achieved, and the method is simple and can be operated by self.
Description
Technical field
] the present invention relates to a kind of medicine for the treatment of diabetes, relate in particular to a kind of Chinese medicine composition of the treatment diabetes of making take vegetable Chinese herbal medicine as raw material.
Background technology
Diabetes are modern high morbidities of one, to continue the one chronic general metabolism disease of hyperglycemia as its basic biochemical character.The symptom main manifestations of diabetes is more than three, polyuria, and polydipsia, polyphagia, muscle power and weight loss, skin pruritus, visual deterioration, as numb hand and foot, palpitation and short breath, diarrhoea constipation, urine pool slips and the chronic complicating diseases such as sexual impotence.At present, the medicine that the treatment of diabetes is used is take Western medicine as main substantially, the toxic and side effects of Western medicine own is large, can produce harmful effect to health, the method of Diabetes Mellitus Treated With Traditional Chinese Medicine is also a lot, but effect is not quite similar, so for effective treatment diabetes, the special Chinese medicine composition that further preferably adopts treatment diabetes of the present invention.
Summary of the invention
Object of the present invention is exactly for more effective treatment diabetes, and a kind of Chinese medicine composition for the treatment of diabetes is provided, and can eliminate patient's illness, promotes physical and mental health, has no side effect, and economical and practical, taking convenience, can Self-operating.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition for the treatment of diabetes, it is characterized in that, and the crude drug of making effective ingredient by following weight parts is: Radix Codonopsis 5-10 part, Radix Astragali 10-20 part, Radix Salviae Miltiorrhizae 10-15 part, Rhizoma Dioscoreae 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Radix Ophiopogonis 5-10 part, Rhizoma Chuanxiong 5-10 part, Carapax Et Plastrum Testudinis 10-15 part, Fructus Crataegi 5-10 part, Ramulus Mori 10-30 part, Radix Rehmanniae 20-30 part, Poria 5-10 part.
Usage: be decocted in water for oral dose, patient can take for one day at twice, for the difficult patient that takes traditional Chinese medicine, can be on a small quantity sub-service repeatedly, within one month, be a course for the treatment of.
Pharmaceutical formulation mechanism of the present invention and constituent component analysis are:
Radix Codonopsis: property is flat, sweet in the mouth, micro-acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, promotes the production of body fluid.Control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty.
The Radix Astragali: sweet in the mouth, tepor.Return lung, spleen, liver, kidney channel.Benefiting QI for strengthening the superficies, inducing diuresis to remove edema, arresting sweating is admittedly de-, the effect of quenching one's thirst, for diabetes, the deficiency of vital energy is weak, the interior-heat symptom such as quench one's thirst.
Radix Salviae Miltiorrhizae: bitter in the mouth, flat, tepor, nontoxic.Enter the heart, Liver Channel.There is promoting blood circulation to remove blood stasis, detumescence hemostasis, anti-inflammatory analgetic, coronary artery dilator, improves myocardial ischemia, reduces blood glucose, calming heart and tranquilizing mind, the effect such as antibacterial.
Rhizoma Dioscoreae: sweet in the mouth, property is flat, nontoxic.Return lung, spleen, kidney channel.Spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission, quenches one's thirst and promotes the production of body fluid, and feed desire is controlled in spleen reinforcing nourishing the stomach, for thirsty think of drink, weak, cadiovascular lipidosis.Rhizoma Dioscoreae contains mucus protein, has and falls hypoglycemic effect, can be used for treating diabetes.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Spleen reinforcing stomach reinforcing, dampness and in.The Rhizoma Atractylodis Macrocephalae has and protects the liver, enhancing human body immunity, antioxidation, the functions such as blood sugar lowering.Cure mainly deficient QI of the spleen and stomach, anorexia, asthenia weak breath etc.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, slightly blood sugar lowering.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, heart channel.Activating QI to alleviate the depression, method wind-dryness is wet, nourshing blood and promoting blood circulation, pain relieving.Control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia etc., Rhizoma Chuanxiong and Radix Salviae Miltiorrhizae compatibility, can reduce microdose urine protein effect.
Carapax Et Plastrum Testudinis: salty in the mouth, sweet, cold nature.Return liver, kidney, heart channel.Nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, the reinforcing the heart of nourishing blood.
Fructus Crataegi: stomach invigorating, removing food stagnancyization are stagnant, the dissipating blood stasis of having a respite, phlegm reduction of blood circulation promoting.Fructus Crataegi energy blood vessel dilating, heart tonifying, increase coronary flow, improve heart vigor, stimulating central nervous system system, reduce blood pressure and cholesterol, vessel softening and diuresis and sedation.
Ramulus Mori: micro-hardship, property is flat, nontoxic.Enter Liver Channel.Lung meridian.Wind-damp dispelling, sharp joint, row aqueous vapor; Control anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen.Polyhydroxylated alkaloid, the DNJ etc. containing in Ramulus Mori can make blood glucose reduce, and delays the degradation process of polysaccharide, and enhanced sensitivity insulin, improves Insulin Resistance.
Radix Rehmanniae: sweet in the mouth, cold in nature.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, YIN nourishing yin nourishing, promotes the production of body fluid; For calentura excessive thirst, send out speckle dermexanthesis, yin asthenia generating intrinsic heat, spits blood, epistaxis, diabetes.Flavin in the Radix Rehmanniae can reduce blood glucose.
Poria: sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, strong lean marrow.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.With Rhizoma Dioscoreae partner treatment diabetes.
The invention has the beneficial effects as follows, all medicine compatibilities of the present invention, have invigorating primordial QI, promote the production of body fluid Gu de-, heat-clearing and toxic substances removing, dispelling wind dredging collateral, relieving restlessness is quenched the thirst, invigorating QI to consolidate the body surface resistance, diuresis poison holding, stomach reinforcing the kidney invigorating, pathogenic fire reducing is moisturized, supplementing QI for promoting the production of body fluid, promotes metabolism, controls the effects such as body weight, the synergism of drug effect, effective control diabetes, make glucose in urine blood glucose reach normal, economical and practical, method is simple, can Self-operating.
Below in conjunction with clinical experiment data declaration beneficial effect of the present invention.
Pharmacology's zoopery
Experimental data
Wistar rat, male, body weight 190-250g.Reference medicine is alloxan, concentration 50mg/ml.
Experimental technique
After 40 Wistar rat fasting 16h, lumbar injection alloxan 200 mg/ml, the blood sampling of 48h ophthalmic corner of the eyes venous plexus, with automatic biochemistry analyzer survey serum blood glucose, except 4 death, 36 blood glucose values of remaininging are 21.7-48.3mmol/L, are into mould animal (blood glucose value >=16.05mmol/L).According to blood glucose value height, divide equally to matched group and treatment group.Treatment group every day 2 times, the morning 8:30, afternoon, 2:30 gastric infusion, weighed weekly once; Every each distilled water 10ml that gives of matched group, every each 2.34g crude drug/kg that gives for the treatment of group.Successive administration is fasting feedwater 16h after 2 weeks, and the blood sampling of ophthalmic corner of the eyes venous plexus, with automatic biochemistry analyzer survey serum blood glucose.
Experimental result
Administration first week, contrast combination treatment group has no significant difference (in table 1), all has animal dead (each 3) in one week.Second week control animals occurs that diet reduces, unable few moving, develops into gradually stupor, 8 death; The situation for the treatment of group animal is better, and amount of drinking water increases by 1 times, only has 2 animals to occur unable symptom.The 3rd week control animals is all dead, and treatment group one had 3 death in 3 weeks, through checking, and P<0.05.Alloxan diabetes rats is through this medicine composite for curing after 2 weeks, and with comparison before self administration, hyperglycemia level has remarkable reduction, and P<0.01, with relatively P<0.01 of matched group.Refer to table 2.
Table 1 alloxan Oral Administration in Rats Chinese medicine composition curative effect of the present invention.
Table 1
2 weeks curative effects of table 2 alloxan Oral Administration in Rats Chinese medicine composition of the present invention.
Table 2
Clinical physical data
Diabetics 80 examples, male 40 examples, female's 40 examples; The oldest person 62 years old, reckling 23 years old, wherein 20-30 year person's 21 examples, 31-40 year person's 20 examples, 41-50 year person's 23 examples, 51-60 year person's 16 examples; The shortest person of the course of disease 6 months, elder 6 years, wherein 1 year with interior patient's 27 examples, 1-2 person's 20 examples, 3-4 person's 17 examples, 5-6 person's 16 examples; Merge various syndrome differentiation person 20 examples, retinopathy person 21 examples, patients with coronary heart disease 13 examples, hyperpietic's 11 examples, cerebrovascular patient 15 examples, are divided into four groups by patient, the factor there was no significant difference such as sex between each group, age, course of disease.
Diagnosis basis
Clinical symptoms is with thirsty polydipsia, polyphagia polyphagia, and urinary micturition, emaciated physique is common.Not remarkable from the beginning of " more than three " symptom (outeat, drinks manyly, urine many), sick Chang Bingfa is for a long time dizzy, pulmonary tuberculosis, the thoracic obstruction, apoplexy, nyctalopia etc.
Lab testing: urinary glucose determination is positive.
Blood sugar detection: fasting glucose > 7.2mmol/L, or within 2 hours after the meal, exceed 11.1mmol/L, glucose tolerance singularity in experiment.
Therapeutic Method
Three groups of decoctions that use respectively specific embodiment 1,2,3 Chinese medicine compositions to prepare in four groups are treated, and potion, divided and took for 2 times every day, and treating one month is a course for the treatment of, other one group is matched group, and matched group is taken glyburide, oral, one day twice, a point morning and evening took, and takes 5mg every day.
Efficacy evaluation
Evaluate according to the related standards of the treating diabetes of " traditional Chinese medical science disease Standardization of diagnosis and curative effect " formulated with reference to State Administration of Traditional Chinese Medicine (Chinese Medicine science and technology publishing house, 2012).
Cure: treat one month, main transference cure, the transference cure of holding concurrently, checks that detecting index for 5 times is tending towards normal;
Take a turn for the better: treat one month, primary symptom takes a turn for the better, the disease of holding concurrently is most of to be disappeared, and test rating meets alleviation condition substantially, the stable disease of taking medicine continuously;
Invalid: treat one month, primary symptom, the disease of holding concurrently check unchanged or increase the weight of.
Therapeutic outcome (in table 3)
Table 3
Toxic and side effects
In clinical research, do not find obvious toxic and side effects.
Treatment conclusion
Chinese medicine composition of the present invention can effectively reduce blood glucose, reaches the object of " control sugar ".Meanwhile, patient body is not had to obvious toxic and side effects, evident in efficacy.
Model case is as follows:
Case one: thank certain, man, 57 years old.Patient's pale complexion, myasthenia of limbs, the ill symptomses such as polyphagia polyphagia, urinate as fat, and xerostomia light red tongue is listless.Hospital diagnosis is diabetes, and readme was taken multiple Chinese medicine and western medicine all to no effect, changed and took this Chinese medicine composition after one month, and symptom alleviates to some extent, serve on 6 months transference cures, has rosy cheeks, and pays a return visit, without recurrence after half a year.
Case two: Yao, female, 38 years old.Occur thirsty polydipsia, urine is frequently many, the ill symptomses such as spanomenorrhea.After 2 years, emaciated physique, myasthenia of limbs, menolipsis, deep pulse, red tongue, is hard and dry, and urine is inferior many, is diagnosed as diabetes through hospital.Take Chinese medicine composition of the present invention after 1 month, symptom alleviates to some extent, serve on 3 months, and frequent micturition, thirsty symptom all disappear, and menstruation is risen as scheduled, and extremity are strong.Take again 5 months, through examination in hospital, recover normal.
The specific embodiment
In order to understand better and to implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take 10 parts of Radix Codonopsis, 20 parts of the Radixs Astragali, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Rhizoma Dioscoreaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Ophiopogonis, 10 parts of Rhizoma Chuanxiongs, 15 parts of Carapax Et Plastrum Testudiniss, 10 parts of Fructus Crataegis, 30 parts of Ramulus Moris, 30 parts of Radix Rehmanniae, 10 parts, Poria, makes Chinese medicine decoction according to conventional method.
Embodiment 2
Preferably take 8 parts of Radix Codonopsis, 16 parts of the Radixs Astragali, 13 parts of Radix Salviae Miltiorrhizaes, 8 parts of Rhizoma Dioscoreaes, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Radix Ophiopogonis, 8 parts of Rhizoma Chuanxiongs, 14 parts of Carapax Et Plastrum Testudiniss, 8 parts of Fructus Crataegis, 25 parts of Ramulus Moris, 25 parts of Radix Rehmanniae, 8 parts, Poria, makes Chinese medicine decoction according to conventional method.
Embodiment 3
Further preferably take 5 parts of Radix Codonopsis, 10 parts of the Radixs Astragali, 10 parts of Radix Salviae Miltiorrhizaes, 5 parts of Rhizoma Dioscoreaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Chuanxiongs, 10 parts of Carapax Et Plastrum Testudiniss, 5 parts of Fructus Crataegis, 10 parts of Ramulus Moris, 20 parts of Radix Rehmanniae, 5 parts, Poria,
Make Chinese medicine decoction according to conventional method.
Medicine is washed, with cold water soak 20-30 minute, medicine is flooded completely, be convenient to the dissolving of effective ingredient, then medicine is placed on to marmite, in the vessel of pottery or crock and so on, (cannot use iron pan and aluminum pot), add the water doubly for medicine 5-10, or exceed 2-3 centimetre of left and right than powder, while decocting first pass, after boiled with big fire, endure about 20 minutes all right with little fire again, medicine soup is poured in vessel, decoct again second time, the method of decocting second time is the same with first pass, just the time can be shorter a little, after having decocted, this twice fried medicine soup is mixed and taken, total amount is greatly about 300-500 milliliter, be divided into 2 parts, sooner or later each portion, can make so fully effect between medicine, effective ingredient stripping is thorough, heighten the effect of a treatment.
Claims (4)
1. a Chinese medicine composition for the treatment of diabetes, is characterized in that, the crude drug of making effective ingredient by following weight parts is: Radix Codonopsis 5-10 part, Radix Astragali 10-20 part, Radix Salviae Miltiorrhizae 10-15 part, Rhizoma Dioscoreae 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Radix Ophiopogonis 5-10 part, Rhizoma Chuanxiong 5-10 part, Carapax Et Plastrum Testudinis 10-15 part, Fructus Crataegi 5-10 part, Ramulus Mori 10-30 part, Radix Rehmanniae 20-30 part, Poria 5-10 part.
2. according to the Chinese medicine composition of the treatment diabetes described in claims 1, it is characterized in that, the crude drug of making effective ingredient by following weight parts is: 10 parts of Radix Codonopsis, 20 parts of the Radixs Astragali, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Rhizoma Dioscoreaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Ophiopogonis, 10 parts of Rhizoma Chuanxiongs, 15 parts of Carapax Et Plastrum Testudiniss, 10 parts of Fructus Crataegis, 30 parts of Ramulus Moris, 30 parts of Radix Rehmanniae, 10 parts, Poria.
3. according to the Chinese medicine composition of the treatment diabetes described in claims 1, it is characterized in that, the crude drug of making effective ingredient by following weight parts is: 8 parts of Radix Codonopsis, 16 parts of the Radixs Astragali, 13 parts of Radix Salviae Miltiorrhizaes, 8 parts of Rhizoma Dioscoreaes, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Radix Ophiopogonis, 8 parts of Rhizoma Chuanxiongs, 14 parts of Carapax Et Plastrum Testudiniss, 8 parts of Fructus Crataegis, 25 parts of Ramulus Moris, 25 parts of Radix Rehmanniae, 8 parts, Poria.
4. according to the Chinese medicine composition of the treatment diabetes described in claims 1, it is characterized in that, the crude drug of making effective ingredient is by following weight parts: 5 parts of Radix Codonopsis, 10 parts of the Radixs Astragali, 10 parts of Radix Salviae Miltiorrhizaes, 5 parts of Rhizoma Dioscoreaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Chuanxiongs, 10 parts of Carapax Et Plastrum Testudiniss, 5 parts of Fructus Crataegis, 10 parts of Ramulus Moris, 20 parts of Radix Rehmanniae, 5 parts, Poria.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561059A (en) * | 2016-01-12 | 2016-05-11 | 李莎莎 | Traditional Chinese medicine composition for treating diabetes, applications, and preparation method thereof |
| CN105833019A (en) * | 2016-03-21 | 2016-08-10 | 东莞市东卓中天生物科技有限公司 | Health care product for treatment of diabetes and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626157A (en) * | 2003-12-12 | 2005-06-15 | 郭文轩 | Method for preparing oral liquid for lowering blood sugar |
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2014
- 2014-04-17 CN CN201410152827.4A patent/CN103877365A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626157A (en) * | 2003-12-12 | 2005-06-15 | 郭文轩 | Method for preparing oral liquid for lowering blood sugar |
Non-Patent Citations (1)
| Title |
|---|
| 屠庆祝等: "浅谈中药治疗糖尿病的用药规律", 《中医药临床杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561059A (en) * | 2016-01-12 | 2016-05-11 | 李莎莎 | Traditional Chinese medicine composition for treating diabetes, applications, and preparation method thereof |
| CN105833019A (en) * | 2016-03-21 | 2016-08-10 | 东莞市东卓中天生物科技有限公司 | Health care product for treatment of diabetes and preparation method thereof |
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