A kind of medicine for the treatment of cholecystitis and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of cholecystitis and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Cholecystitis is more common disease, and sickness rate is higher, and normal and cholelithiasis merges and exists.During outbreak, upper right abdomen severe pain or angor, mostly be calculus or parasite incarceration and block acute cholecystitis caused by neck of gallbladder, pain often breaks out, and very acutely, or presents angor sample.During cystic duct non-obstructivity acute cholecystitis, right Upper abdominal pain is general inviolent, and mostly be persistence distending pain, along with the progress of gallbladder inflammation, pain also can increase the weight of, and pain presents radioactivity, and modal radiation position is the place such as right shoulder and right inferior angle of scapula.Because current Western medicine effectively cannot treat cholecystitis, therefore there is great demand in the Chinese medicine of people to rapid, effective treatment cholecystitis, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment cholecystitis, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment cholecystitis.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Radix Scutellariae, Herba Lysimachiae, the Radix Paeoniae Alba, Fructus Crataegi, Radix Glycyrrhizae, Herba Artemisiae Scopariae, Fructus Gardeniae, Fructus Toosendan, Semen Plantaginis, Massa Medicata Fermentata, Endothelium Corneum Gigeriae Galli, Fructus Aurantii Immaturus, Rhizoma Corydalis, Rhizoma Alismatis, Fructus Hordei Germinatus, Radix Curcumae, Radix Et Rhizoma Rhei, Radix Bupleuri, the Radix Aucklandiae, Fructus Citri Sarcodactylis, Herba Taraxaci, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Spora Lygodii medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat cholecystitis.Wherein select Radix Scutellariae to be because its nature and flavor bitter cold, enter cardiopulmonary, gallbladder, large intestine channel, have removing the relative excess fire, except damp and hot, the function of arresting bleeding and miscarriage prevention, controls high fever excessive thirst, cough due to lung-heat.Herba Lysimachiae is selected to be because its nature and flavor toil, cool, there is heat clearing away, diuresis, antitussive, detumescence, the function of removing toxic substances, subcutaneous ulcer of harnessing the Yellow River, edema, vesical calculus, malaria, lung abscess, cough, spit blood, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, infantile malnutrition , Jing Epilepsy, carbuncle, skin ulcer tinea, eczema.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Fructus Crataegi be because its nature and flavor acid sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function, controls meat Ji , mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate.Radix Glycyrrhizae is selected to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription; Process use, control taste lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus , Jing Epilepsy; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, carbuncle subcutaneous ulcer skin infection, separates poison of drug and alimentary toxicosis.Herba Artemisiae Scopariae is selected to be because its nature and flavor toil, cool, enter liver, spleen, urinary bladder channel, have the function of clearing away heat-damp and promoting diuresis, control jaundice due to damp-heat, dysuria, pruritus due to wind pathogen skin ulcer scabies.Select Fructus Gardeniae to be because its nature and flavor are bitter, cold, enter the heart, liver, lung, stomach warp, have heat clearing away, pathogenic fire purging, the function of removing heat from blood, control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Select Fructus Toosendan to be because its nature and flavor are bitter, cold, poisonous, enter liver, stomach, small intestine meridian, have wet down heat, clearing away liver-fire, pain relieving, the function of parasite killing, controls epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.Semen Plantaginis is selected to be that cold, enter kidney, urinary bladder channel, have diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, and arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view because its nature and flavor are sweet.Select Massa Medicata Fermentata to be that warm, have strengthening the spleen to promote digestion, regulating QI to expel dampness, the function of inducing sweat, cure the wound the food feeling of stuffiness in chest because its nature and flavor are bitter, stomachache is vomited and diarrhoea, dysentery, headache due to common cold, and children's hinders hungry mistake and satisfies.Select Endothelium Corneum Gigeriae Galli to be because its nature and flavor are sweet, flat, enter spleen, stomach warp, control stagnant, the function of strengthening the spleen and stomach, control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.Select Fructus Aurantii Immaturus to be because its nature and flavor are bitter, cold, enter spleen, stomach warp, have dispelling the stagnated QI, loose painful abdominal mass, rush down expectorant, the function of removing food stagnancy, controls chest and abdomen swelling and pain, the thoracic obstruction, painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse, proctoptosis.Rhizoma Corydalis is selected to be that temperature, enter liver, stomach warp, invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, the function of pain relieving, controls all pains of trusted subordinate's waist knee joint, menoxenia , mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury because its nature and flavor are worked hard.Select Rhizoma Alismatis to be that cold, enter urinary bladder channel, have diuretic, eliminating dampness by diuresis, the function expelled the heat-evil, controls dysuria because its nature and flavor are sweet, edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Fructus Hordei Germinatus is selected to be that tepor, enters spleen, stomach warp, have and help digestion because its nature and flavor are sweet, and in, the function of the therapeutic method to keep the adverse QI flowing downwards, controls food stagnation and does not disappear, swollen distention and fullness in the abdomen, inappetence, and vomiting is had loose bowels, and mammary swelling does not disappear.Radix Curcumae is selected to be because its nature and flavor are worked hard, cool, enter the heart, lung, Liver Channel, have circulation of qi promoting solution with, the function of removing heat from blood removing blood stasis with potent drugs, control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Radix Et Rhizoma Rhei is selected to be that enter stomach, large intestine, liver footpath, have the poison that purges heat, removing mass is stagnant because its nature and flavor are bitter, cold, the function of clots absorbing blood, control excess-heat constipation, delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi , lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Select Radix Bupleuri to be that cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain because its nature and flavor are bitter, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Select the Radix Aucklandiae to be that temperature, enters lung, liver, spleen channel, have promoting the circulation of QI to relieve pain, the function of warming middle-JIAO for easing the stomach, control the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain because its nature and flavor are worked hard, vomiting, has loose bowels, dysentery tenesmus, colic of cold type.Selecting Fructus Citri Sarcodactylis, different name Fructus Citri Sarcodactylis, Bergamot, is that temperature, enter liver, stomach warp, regulate the flow of vital energy, the function of reducing phlegm, treats for stomachache, and coerces swollen, vomiting, dysphagic, phlegm retention cough with asthma, and can relieve the effect of alcohol because the arduous acid of its nature and flavor.Select Herba Taraxaci to be because its property bitter but sweet flavor, cold, enter liver, stomach warp, have heat-clearing and toxic substances removing, the function of diuresis eliminating stagnation, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Select Pericarpium Citri Reticulatae Viride to be that tepor, enters liver, gallbladder meridian, has soothing the liver dispelling the stagnated QI, the function of eliminating stagnation expectorant because its nature and flavor toil, control breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction block.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Select Spora Lygodii to be because its property slightly sweet flavor, cold, enter small intestinal, urinary bladder channel, have heat-clearing and toxic substances removing, the function of relieving stranguria by diuresis, controls urinary tract infection, lithangiuria, nebulousurine, leucorrhea, hepatitis, oedema due to nephritis, laryngopharynx swelling and pain, mumps, enteritis, dysentery, skin eczema, herpes zoster.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight
Radix Scutellariae 10-20 gram of Herba Lysimachiae 10-20 gram of Radix Paeoniae Alba 10-20 gram
Fructus Crataegi 10-20 gram of Radix Glycyrrhizae 10-20 gram of Herba Artemisiae Scopariae 10-20 gram
Fructus Gardeniae 8-15 gram of Fructus Toosendan 8-15 gram of Semen Plantaginis 10-20 gram
Massa Medicata Fermentata 10-20 gram of Endothelium Corneum Gigeriae Galli 8-15 gram of Fructus Aurantii Immaturus 10-20 gram
Rhizoma Corydalis 10-20 gram of Rhizoma Alismatis 8-15 gram of Fructus Hordei Germinatus 8-15 gram
Radix Curcumae 10-20 gram of Radix Et Rhizoma Rhei 8-15 gram of Radix Bupleuri 8-15 gram
Radix Aucklandiae 8-15 gram of Fructus Citri Sarcodactylis 8-15 gram of Herba Taraxaci 8-15 gram
Pericarpium Citri Reticulatae Viride 8-15 gram of Pericarpium Citri Reticulatae 8-15 gram of Spora Lygodii 10-20 gram
Be preferably
Radix Scutellariae 15 grams of Herba Lysimachiaes 15 grams of Radix Paeoniae Albas 15 grams
Fructus Crataegi 15 grams of Radix Glycyrrhizaes 15 grams of Herba Artemisiae Scopariae 15 grams
Fructus Gardeniae 10 grams of Fructus Toosendans 10 grams of Semen Plantaginiss 15 grams
Massa Medicata Fermentata 15 grams of Endothelium Corneum Gigeriae Galli 10 grams of Fructus Aurantii Immaturuss 15 grams
10 grams, Rhizoma Corydalis 15 grams of Rhizoma Alismatis 10 grams of Fructus Hordei Germinatus
Radix Curcumae 15 grams of Radix Et Rhizoma Rhei 10 grams of Radix Bupleuri 10 grams
The Radix Aucklandiae 10 grams of Fructus Citri Sarcodactyliss 10 grams of Herba Taraxacis 10 grams
Pericarpium Citri Reticulatae Viride 10 grams of Pericarpium Citri Reticulataes 12 grams of Spora Lygodii 15 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;
2, Herba Lysimachiae: pick clean impurity, sieve dedust bits, dry;
3, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
4, Fructus Crataegi: pick clean impurity, sieve enucleation;
5, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;
6, Herba Artemisiae Scopariae: sieve, picks decontamination, and removing undesirable root, pulverizes, remove spare after sieve;
7, Fructus Gardeniae: sieve dedust bits, pick decontamination, pulverize and sieve or cut off two ends;
8, Fructus Toosendan: pick decontamination, cleans, and dries, grating or cleave in two;
9, Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
10, Massa Medicata Fermentata: original is used as medicine;
11, Endothelium Corneum Gigeriae Galli: pick decontamination, rinses and dries;
12, Fructus Aurantii Immaturus: pick clean impurity, be soaked in water to eighty per cant thoroughly, pull out, profit, to interior without hard-core, cut into slices, is dried;
13, Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
14, Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;
15, Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put micro-stir-fry extremely yellow in pot, taking-up cools;
16, Radix Curcumae: be soaked in water, cleans, pulls solarization out and dry in the air, run through, and section, dries;
17, Radix Et Rhizoma Rhei: pick clean impurity, size stepping, stews to moisten to inside and outside humidity even, cuts into slices or is cut into small pieces, dries;
18, Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry;
19, the Radix Aucklandiae: put by crude drug in whole in clear water and clean, pull out, moistening makes soft for 12-24 hours, section, dries;
20, Fructus Citri Sarcodactylis: pick decontamination, after water spray profit, chopping, dries;
21, Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
22, Pericarpium Citri Reticulatae Viride: pick clean impurity, be soaked in water, pull out, run through, section, dries;
23, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
24, Spora Lygodii: get crude drug, crosses dusting cover, and sieve gets spore, removing impurity.
Two, prepare
1, the Radix Scutellariae of described weight, Herba Lysimachiae, the Radix Paeoniae Alba, Fructus Crataegi, Radix Glycyrrhizae, Herba Artemisiae Scopariae, Fructus Gardeniae, Fructus Toosendan, Semen Plantaginis, Massa Medicata Fermentata, Endothelium Corneum Gigeriae Galli, Fructus Aurantii Immaturus, Rhizoma Corydalis, Rhizoma Alismatis, Fructus Hordei Germinatus, Radix Curcumae, Radix Et Rhizoma Rhei, Radix Bupleuri, the Radix Aucklandiae, Fructus Citri Sarcodactylis, Herba Taraxaci, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Spora Lygodii are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor.
2, add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor.
3, merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into 3 doses to take.
Medicine of the present invention has heat-clearing and toxic substances removing, the function of regulating QI to relieve pain, is used for the treatment of cholecystitis instant effect, good effect.Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 100 examples for medical treatment.
2, diagnostic criteria
1. be inducement mainly with edible greasy food.2. the upper right abdomen persistence that happens suddenly has an intense pain and accompanies paroxysmal to increase the weight of, and can radiate by scapular region to the right, often have Nausea and vomiting, heating.3. upper right abdomen has tenderness, muscle tonus, and Murphy sign is positive, the visible jaundice of minority.4. leukocyte and neutrophil count increase, and serum icterus index and bilirubin may increase.5. the visible gollbladder dilation of B ultrasonic, thickening of capsule wall of gallbladder or crude, has flying-spot in capsule, with calculus image visible during calculus.6. x-ray inspection: gallbladder area plain abdominal radiograph can have gallbladder to increase shade.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, every day 2 times, each 1 dose, sooner or later service once, within 7 days, be 1 course for the treatment of, take 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: cholecystitis symptom is fully recovered, recover normal.
Take a turn for the better: cholecystitis symptom alleviates, and progressively takes a turn for the better.
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by Drug therapy cholecystitis 100 example of the present invention, effective 79 examples of result, obvious effective rate is 79%, and take a turn for the better 5 examples, and improvement rate is 5%, and invalid 16 examples, total effective rate is 84%.