CN104173921B - A kind of Chinese medicine composition and its preparation and purposes - Google Patents

Abstract

The invention belongs to pharmaceutical technology field, and the invention provides a kind of Chinese medicine composition and its preparation and purposes, Chinese medicine composition of the present invention includes：The parts by weight of desmodium 10 30, the parts by weight of Lygodium japonicum 10 30, the parts by weight of oriental wormwood 10 30, the parts by weight of the root of herbaceous peony 10 30, the parts by weight of Fructus meliae toosendan 10 30, the parts by weight of rhizoma pinellinae praeparata 5 15, the parts by weight of rheum officinale 5 15, the parts by weight of root tuber of aromatic turmeric 5 15, the parts by weight of radix bupleuri 10 30, the parts by weight of radix scutellariae 10 30, the parts by weight of Fructus Aurantii 5 15, the parts by weight of Asiatic plantain 20 40, the parts by weight of dandelion 20 40.Chinese medicine composition of the present invention is on the basis of clinical research for many years, is obtained by creative work, has the effect such as treatment cholecystitis well.

Description

A kind of Chinese medicine composition and its preparation and purposes

Technical field

The invention belongs to pharmaceutical technology field, and in particular to it is a kind of have treatment cholecystitis effect Chinese medicine composition and its Preparation.

Background technology

Shown according to epidemiology survey result, the crowd in the whole world 5%~15% has biliary system calculus, wherein every year The patient for having 1%~3% causes the biliary systems such as acute cholecystitis or acute cholangitis to infect because of biliary system calculus.I State biliary system calculus patient accounts for the 11.5% of the same period total number of hospitalized^[1].According to the cause of disease of acute cholecystitis and prognosis, courage Capsulitis is divided into acute cholecystitis and chronic cholecystitis, and acute cholecystitis is the acute chemical and (or) bacterial inflammation that gall-bladder occurs Disease is reacted.Wherein 90%~95% patient is associated with cholecystolithiasis, referred to as acute calculosis cholecystitis, 5%~10% urgency Property cholecystitis and intracapsular bile of gallbladder stasis of blood product, pyemia and mucous membrane ischemic it is relevant be acute acalculous cholecystitis.Acute non-calculus Property cholecystitis be a kind of acute cholecystitis of specific type, usual onset is serious, and prognosis is poorer than acute calculosis cholecystitis, total disease Dead rate is 15%^[2].Acute cholecystitis case accounts for the 3%~10% of all stomachache patients.Acute cholecystitis stomachache the elderly is common (50 years old and above patient).Patient shows acute lasting upper right abdomen stomachache, fever, nausea and vomiting mostly；Acute gall-bladder The result of scorching recurrent exerbation is exactly chronic cholecystitis.The western medical treatment on cholecystitis and cholecystolithiasis focuses mostly in anti-at present Scorching, row's stone, spasmolysis and habits and customs change, and can not effect a radical cure, be only capable of relief of symptoms.Traditional Chinese medicine is for cholecystitis and gall-bladder The diagnosis and treatment of calculus are with a long history, have wide experience, although lacking large sample clinical trial, empirical Chinese traditional treatment effect at present Definitely^[3]。

Cholecystitis refers to the active chronic inflammation reaction of gallbladder wall.Cholecystitis is most common using operative treatment as leading disease One of disease, and one of most common enterogastric diseases.Cholecystitis had been considered as once a kind of disease in west.Research is reported in The U.S., estimation have influence on 20~250,000 adults.According to cholecystitis whether with cholecystolithiasis can be divided into calculous cholecystitis and Non- calculous cholecystitis.Cholecystitis again can be by the anxious course of disease that relaxes of morbidity by being divided into acute cholecystitis and chronic cholecystitis.And root The order of severity for involving gall-bladder according to inflammation is divided into pure and suppurative cholecystitis.70%~95% conjunction is there are about in cholecystitis And cholecystolithiasis, remaining can be concurrently in chronic hepatitis, AML, fatty liver diseases.Calculous cholecystitis with women and The elderly is the most common, and its incidence of disease increases with the rise at age.

Cholelithiasis is modern medicine name of disease, and it is included in the models such as " courage is swollen ", " liver is swollen ", " jaundice " by traditional Chinese medicine Farmland,《Qianjin Yao Fang》Say：" evil in courage, inverse in stomach, upward overflow of bile giving rise to bitter taste in mouth, stomach Qi is inverse then to vomit." liver and courage catharsis malfunction It is the basic pathogenesis of gall stone.Cholelithiasis is more because seven feelings pent-ups, eating and drinking without temperance etc. are caused by.The gallbladder being attached to the liver, liver and gall table each other In, bile by liver vital essence institute metaplasia.The Zang-Fu relationships such as pathogenesis and liver and gall taste are close, and courage is one of six internal organs, is to lead to Suitable, liver dysfunction, bile excretion is not smooth, decocts with the passing of time, turns into sandstone.Huang Baixiong was said：" liver being bold and firm viscera, there is pent-up, gas fire is all Rise, upper criminal's stomach, connect two sides of body bitterly." " evil courage, inverse in stomach ", therefore control courage in principle and must control stomach, control stomach also while control courage. Treatment by Chinese herbs is based on " thin ", " clear ", " logical ", " profit ".

Cholecystitis was apt to occur between 20~50 years old.Women is common compared with male, has the characteristics of recurrent exerbation.Often because diet loses The factors such as section, being invaded by exogenous pathogen,invasion of exogenous pathogen, feelings will are unsuccessful, worm stone blocks, overworked induce.Though the traditional Chinese medical science is without acute cholecystitis and chronic gall-bladder Scorching name of disease, but early in《Interior warp》Just there is related discussion.《Ling Shu Miraculous Pivot or Divine Axis five is evil》Say ":It is evil in liver, then pain in two sides of body.”《Plain Questions Miao Ci is discussed》Say ":Evil visitor in few sun enough, network, make us hypochondriac pain and be unable to breathe freely.”《This Tibetan of Ling Shu Miraculous Pivot or Divine Axis》Meaning " courage is swollen person, hypochondrium fullness and pain Draw underbelly." therefore according to clinical manifestation, acute cholecystitis is attributable to " hypochondriac pain " category, and chronic cholecystitis belongs to " courage is swollen " category. Logical drop is lost with courage, " not general rule pain " be basic pathogenesis, and its sick position is in courage internal organs, with the liver dysfunction, dysfunction of the spleen in transport, stomach Qi rising close It is related.

Discussion of motherland's medical science to the disease can sporadically appear in related contents such as courage is swollen, hypochondriac pain, jaundice.Its etiology and pathogenesis is recognized Know, mainly there are following several respects：1. feelings will is unsuccessful：If because feelings will is hindered, the violent rage impariment of the liver, depression is not relaxed, and causes stagnation of liver qi, and courage loses Logical drop, bile stasis, general rule pain, does not send out as this disease.2. intemperance of taking food：Addiction delicious food savoury, or immoderate, impairing the spleen and stomach of being addicted to drink, Burnt transformation failure of spleen in cause, disturbance in ascending and descending, soil heap soil or fertilizer over and around the roots wood is strongly fragrant, and suffocating of liver and gall is not smooth, and courage internal organs is obstructed, sends out as this disease.3. being invaded by exogenous pathogen,invasion of exogenous pathogen：Outside Feel Shi Re Bing Pian, it is damp and hot to from superficies to interior, inside accumulate middle Jiao, suffocating of liver and gall dereliction of duty, FU QI being obstructed；Or excessive noxious heat, courage internal organs is pented up, is made Blood loses meat corruption, accumulate into purulence, sends out as this disease；Or diseases caused by external factors cold-evil, heresy enter few sun, cold-evil stagnates, suffocating of liver and gall dereliction of duty, and courage internal organs is strongly fragrant It is stagnant.4. worm stone blocks：Disturbed on roundworm, dysfunction of acting as a pivot, courage internal organs leads to drop and is obstructed；Or because retention of damp-heat in the interior, suffocating of liver and gall dereliction of duty, bile are strongly fragrant Product, excretion are obstructed, and decoct into stone, and courage internal organs mechanism of qi is obstructed, and general rule pain, does not send out as this disease.5. internal lesion caused by overexertion is excessive：Weakness due to chronic disease, labor are intended to Excessively so that deficiency of YIN-blood, courage network, which loses, supports, and train of thought arrested anxious, courage loses logical drop, and Rong Ze pains, do not send out as this disease.

The traditional Chinese medical science thinks cholecystitis acute cholecystitis based on real example, and chronic cholecystitis is common with syndrome of intermingled deficiency and excess.More because of liver Lose catharsis, the dysfunction of the spleen in transport, it is stomach Qi rising caused by.The treatment of cholecystitis according to " symptomatic treatment in acute condition, radical treatment in chronic case " principle.Treatment is big Method is：Soothing liver-gallbladder.Acute cholecystitis is often with clearing away heat and eliminating dampeness, logical internal organs cholagogic method, clearing heat and detoxicating, removing heat by catharsis purges intense heat method treatment；It is chronic Cholecystitis often leads to internal organs method with soothing liver-gallbladder, regulating the flow of vital energy Xie Yu method, clearing heat and promoting diuresis, cholagogic, dredges sharp liver and gall, Wen Han activates yang method, and qi-regulating is lived Blood, cholagogic analgesia, soothing liver and strengthening spleen, soft liver cholagogic method, Yangyin Rougan liver, the treatment of clearing heat secreting bile method.

At present, the incidence of disease of cholecystitis is gradually increasing, and the method for treating cholecystitis both at home and abroad is varied, but because of courage The easy recurrent exerbation of capsulitis, various treatment methods are still unsatisfactory, and cholecystitis, which is still one, the problem of to be solved.

The content of the invention

The purpose of the present invention is to overcome the shortcomings of present in prior art, there is provided a kind of medicine source is enriched, cheap, to courage A kind of good Chinese medicine composition of capsulitis action effect.The present invention combines clinical practice, using soothing liver-gallbladder as base therapy principle, hair Understand a kind of compound of anti-inflammatory cholagogic treatment cholecystitis, obtain the effect of relatively satisfactory.

Prescription Prescription analysis

Cholelithiasis is modern medicine name of disease, and it is included in the models such as " courage is swollen ", " liver is swollen ", " jaundice " by traditional Chinese medicine Farmland,《Qianjin Yao Fang》Say：" evil in courage, inverse in stomach, upward overflow of bile giving rise to bitter taste in mouth, stomach Qi is inverse then to vomit." liver and courage catharsis malfunction It is the basic pathogenesis of gall stone.Cholelithiasis is more because seven feelings pent-ups, eating and drinking without temperance etc. are caused by.The gallbladder being attached to the liver, liver and gall table each other In, bile by liver vital essence institute metaplasia.The Zang-Fu relationships such as pathogenesis and liver and gall taste are close, and courage is one of six internal organs, is to lead to Suitable, liver dysfunction, bile excretion is not smooth, decocts with the passing of time, turns into sandstone.Huang Baixiong was said：" liver being bold and firm viscera, there is pent-up, gas fire is all Rise, upper criminal's stomach, connect two sides of body bitterly." " evil courage, inverse in stomach ", therefore control courage in principle and must control stomach, control stomach also while control courage. Treatment by Chinese herbs is based on " thin ", " clear ", " logical ", " profit ".This prescription prescription meets traditional Chinese medical theory.

In the prescription desmodium it is sweet it is light and flat there is soothing liver-gallbladder, regulating qi-flowing for relieving pain, dehumidifying removing jaundice, inducing diuresis for treating strangurtia, removing toxic substances disappear The effect of swollen.For eliminating dampness and heat, fossil, dissolve stone, the key medicine for arranging stone, contain flavonoids and phenolic compound in desmodium, they By promoting choleresis and gall bladder emptying to have the function that cholagogic^[4,5,6], monarch drug in a prescription desmodium can prevent calculus in preparation And invigorating gallbladder and removing gall-stone, the detumescence of Lygodium japonicum promoting diuresis for stranguria, row's stone can be assisted；Modern study proves：This product can promote hepatocytes secrete courage Juice, bile increases in hepatic duct, and internal pressure increases, and Oddi's sphincter relaxation, promotes bile to discharge；Lygodium japonicum is sweet cold, under its property Drop, can tonneau water channel, and can Qinghua is damp and hot, row's stone；The root of herbaceous peony is cool in nature, bitter acid, is slightly cold, Return liver, the spleen channel, function have heat-clearing Cool blood, smooth liver and relieve pain.Can be with nourishing blood and promoting blood circulation, dispersing stagnated hepatoqi, suppressing liver-YANG, reducing fever and causing diuresis, promoting the circulation of qi of enriching blood, tonifying spleen and stopping diarrhea^[7], in vain Chinese herbaceous peony plays the role of antipyretic, cholagogic, antibacterial；Radix scutellariae bitter, it is cold in nature.Return lung, courage, spleen, stomach, large intestine, small intestinl channel, function have heat-clearing Eliminating dampness, purging intense heat and detonicating play the role of anti-inflammation, and it is we that two medicine compatibilities, which enhance the dampness removing yellow, effect of dredging intestines that disappears, Monarch drug in a prescription.Root tuber of aromatic turmeric, it is pungent, bitter, cold, enter conscience lung footpath, the promoting flow of qi and blood circulation, with the soothing the liver promoting the circulation of qi of Fructus meliae toosendan, analgesic cholagogic；Fructus Aurantii qi-regulating and In, make QI movement being in harmonious way, taste lifting is normal, and rheum officinale share can rush down clearly sun it is bright in it is real；Oriental wormwood matches somebody with somebody rheum officinale clearing heat and promoting diuresis, and heresy has Place to go.Asiatic plantain picric acid is cool, enters liver and gall kidney, bladder footpath, has clearing away heat and promoting diuresis with dandelion, Tonglin Paishi, be in prescription above Ministerial drug；The tuber of pinellia, pungent, temperature.It is poisonous.Returns spleen, stomach, lung channel, effect are eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass；And supervise Huang A kind of reed mentioned in ancient books, assistant are with rheum officinale, and the logical intestines that purge heat, the effect of being enriched blood by the stasis of blood, radix bupleuri energy soothing liver-gallbladder heat-clearing, in rising Yang, and inducing diaphoresis, qi-regulating stops Bitterly, and there is priming channel tropism；So all medicine compatibilities long memorial liver and qi altogether, clearing heat and promoting diuresis, the effect of invigorating gallbladder and removing gall-stone.So that liver Courage machine is happy, the stagnation of the circulation of vital energy must remove, it is damp and hot clearly, calculus must change, courage network must be logical, sick must control and have no side effect, all medicines share can promote Enter inflammation to absorb, edema extinction, reach the purpose of anti-inflammatory and choleretic.

Specifically, the invention provides：

A kind of Chinese medicine composition, its Chinese medicine composition include：Desmodium 10-30 parts by weight, Lygodium japonicum (cloth bag) 10-30 weights Measure part, oriental wormwood 10-30 parts by weight, root of herbaceous peony 10-30 parts by weight, Fructus meliae toosendan 10-30 parts by weight, rhizoma pinellinae praeparata 5-15 parts by weight, rheum officinale (under rear) 5-15 parts by weight, root tuber of aromatic turmeric 5-15 parts by weight, radix bupleuri 10-30 parts by weight, radix scutellariae (under rear) 10-30 parts by weight, Fructus Aurantii 5- 15 parts by weight, Asiatic plantain 20-40 parts by weight, dandelion 20-40 parts by weight.

Wherein preferable Chinese medicine composition includes：The parts by weight of desmodium 15.5, the parts by weight of Lygodium japonicum (cloth bag) 15.5, oriental wormwood 15.5 parts by weight, the parts by weight of the root of herbaceous peony 15.5, the parts by weight of Fructus meliae toosendan 15.5, the parts by weight of rhizoma pinellinae praeparata 10.5, rheum officinale (under rear) 10.5 weights Measure part, the parts by weight of root tuber of aromatic turmeric 10.5, the parts by weight of radix bupleuri 10.5, radix scutellariae (under rear) 15.5 parts by weight, the parts by weight of Fructus Aurantii 10.5, Asiatic plantain 30.5 parts by weight, the parts by weight of dandelion 30.5.

Chinese medicine composition described above is prepared into pharmaceutical preparation.

Pharmaceutical preparation described above includes decoction, tablet, capsule and granule.

A kind of Chinese medicine composition described above is preparing the application in treating cholecystitis medicine.

Decoction preparation method described above is：

Remove the outer 11 taste medicinal materials of rheum officinale, radix scutellariae and add 10-15 times of water, after soaking 20-40 minutes, carried in extractor heating Take twice, extract 2-4 times, decoct 0.5-2h every time；Rheum officinale, radix scutellariae soak when extracting for the 2nd time under 70 DEG C of conditions above It is optimised process that extraction 0.5-2h is added after processing, merges extract solution, filtration, quiescent setting 10 hours, takes supernatant concentration extremely Filling heat-sealing when density is 1.08g/ml；Daily 1 dose is decocted in water for oral dose, each 250ml, takes for 2 times sooner or later.Finished product soup as of the present invention Agent.

Process for producing granula described above is：

Remove the outer 11 taste medicinal materials of rheum officinale, radix scutellariae and add 10-15 times of water, after soaking 20-40 minutes, heating extraction, extract 2-4 It is secondary, decoct every time 0.5-2 hours, radix scutellariae adds extraction when extracting for the 2nd time under 70 DEG C of conditions above after immersion treatment 0.5-2h is optimised process, merges extract solution, filtration, it is standby to be concentrated into the thick paste that 25 DEG C of density are 1.20g/ml；Rheum officinale crushes It is standby to cross 100 mesh sieves, being mixed and made into dried cream powder with 12 kinds of medicinal extract feeds intake, and it is 1.5 separately to take dextrin and galactose ratio:1, equal increments Method is well mixed, and adds 0.5% Aspartame, raw material, auxiliary material are well mixed, using 75% ethanol as diluent, thick paste With auxiliary material 1:2.5 ratio mixing, wet granulation, 80 DEG C of drying, whole grain produce.Finished particle agent as of the present invention.

The preparation method of tablet described above is：

Remove the outer 11 taste medicinal materials of rheum officinale, radix scutellariae and add 10-15 times of water, after soaking 20-40 minutes, heating extraction, extract 2-4 It is secondary, decoct every time 0.5-2 hours, radix scutellariae adds extraction when extracting for the 2nd time under 70 DEG C of conditions above after immersion treatment 0.5-2h is optimised process, merges extract solution, and filtration is concentrated into the thick paste that 25 DEG C of density are 1.20g/ml, and rheum officinale crushed 100 Mesh sieve is standby, and being mixed and made into dried cream powder with 12 kinds of medicinal extract feeds intake, and it is 1.5 separately to take dextrin and galactose ratio:1, equal increments method is mixed Close uniform, add 0.5% Aspartame, raw material, auxiliary material are well mixed, using 75% ethanol as diluent, thick paste with it is auxiliary Material 1:2.5 ratio mixing, wet granulation, 80 DEG C of drying, whole grain tabletting, is produced.Finished tablet as of the present invention.

The preparation method of capsule described above is：

Remove the outer 11 taste medicinal materials of rheum officinale, radix scutellariae and add 10-15 times of water, after soaking 20-40 minutes, heating extraction, extract 2-4 It is secondary, decoct every time 0.5-2 hours, radix scutellariae adds extraction when extracting for the 2nd time under 70 DEG C of conditions above after immersion treatment 0.5-2h is optimised process, merges extract solution, and filtration is concentrated into the thick paste that 25 DEG C of density are 1.20g/ml, and rheum officinale crushed 100 Mesh sieve is standby, and being mixed and made into dried cream powder with 12 kinds of medicinal extract feeds intake, and it is 1.5 separately to take dextrin and galactose ratio:1, equal increments method is mixed Close uniform, add 0.5% Aspartame, raw material, auxiliary material are well mixed, using 75% ethanol as diluent, thick paste with it is auxiliary Material 1:2.5 ratio mixing, wet granulation, 80 DEG C of drying, whole grain adds lubricant, encapsulated, produces.Finished product as of the present invention Capsule.

Embodiment

Below by way of the description of embodiment, the invention will be further described, but this is not the limit to the present invention System, those skilled in the art according to the present invention basic thought, various modifications may be made or improve, but without departing from this The basic thought of invention, within the scope of the present invention.

First, the clinical observation of anti-inflammatory cholagogic Chinese medicine composition treatment cholelithiasis

The present invention highlights the characteristic of western medicines in treatment, and to cholecystitis special effect, curative effect is fast, short treating period, and curative effect is stable Do not recur, 15 are 1 course for the treatment of, take altogether 2~3 courses for the treatment of can rehabilitation, and noninvasive painless, natural Chinese traditional medicines are easy to use, without appointing What toxic side effect.This prescription is applied to various types of cholecystitis, the clinical verification through clinical 2645 patients, quick, treats Effect is definite, and effective percentage up to 95.77%, complication is low, and long-term effect is good, has certain science, advance and practicality. The raw material sources of the present invention are extensive, super quality and competitive price, and cost is low.In terms of curative effect, good results, so this therapy clinically has one Determine promotional value.

1. clinical data：There is outpatient service and the inpatient totally 2645 of complete data selected from January, 2010 in May, 2014 Example.It is randomly divided into treatment group 1324, control group 1321.Treatment group's age is 18-70 year, course of disease 1-15, control group year Age, age and the course of disease were through Chi-square Test, no statistical significant difference (ρ 21-67 year, course of disease 1.5-13>0.05).

2. diagnostic criteria：Most patients have upper right abdomen or upper abdomen distending pain, pain and are radiated to right shoulder back, with evil The heart, poor appetite, visible biliary tract " triad " (jaundice, shiver with cold, stomachache) when blocking biliary tract.Confirm to be diagnosed as gall-bladder, courage through B ultrasound House steward and calculus of intrahepatic duct.Foundation《New Chinese medicine guideline of clinical investigations (tentative)》In chronic cholecystitis diagnosis mark Standard, reference《Chinese Internal Medicine》Traditional Chinese medical science dependent diagnostic standard, with reference to national " the Seventh Five-Year Plan " brainstorm subject " Professor Deng Jianhua hypochondriac pain Diagnosis and treatment computer system " TCM syndrome diagnostic criteria, it is divided into 5 kinds of card types.1. irritability stasis type.Primary symptom：The distending pain in hypochondrium, it is swollen very In pain or based on swollen, emotional factors are every can be induced or aggravate.Secondary disease：Dysmenorrhoea is indefinite, fullness and discomfort in chest and hypochondrium, swollen breasts, and menstruation is not Adjust, sighing frequently, like belch, fart frequency turns, distention and pain in the lower abdomen.Tongue vein：Thin white fur of tongue, veins string.2. hepatogastric vital energy stagnation type.Primary symptom：Side of body rib Distending pain, company and gastral cavilty.Secondary disease：Emotional factors are per that can induce or aggravate, and fullness and discomfort in chest and hypochondrium, deficiency of food is indigestion and loss of appetite, like belch, nausea, vomit, Noisy, sour regurgitation, sighing frequently, dysmenorrhoea is indefinite, swollen breasts, irregular menstruation.Tongue vein：Thin white fur of tongue, white or micro- greasy, wiry and frequent pulse or string It is sliding.3. liver stomach wind-cold type.Primary symptom：Hypochondriac pain is scorching hot, company and gastral cavilty.Secondary disease：Dry mouth with bitter taste, noisy, sour regurgitation, yellow urine, constipation, mouth Smelly, aphtha, toothache, flushing hot eyes, nausea and vomiting, deficiency of food is indigestion and loss of appetite, dysphoria, fullness and discomfort in chest and hypochondrium.Tongue vein：Tongue is red, yellow tongue fur, veins string Number or string are slided.4. liver gallbladder damp-heat type.Primary symptom：Bitter taste mouth glues, fullness and discomfort in chest and hypochondrium, the vexed abdominal distension of gastral cavity.Secondary disease：Nausea and vomiting, body mesh cadmium yellow, Deficiency of food is indigestion and loss of appetite, and dry is not intended to drink, skin itch, yellow urine, constipation.Tongue vein：Red tongue body, yellow and greasy fur, wiry and rolling pulse.5. liver-yin is not Sufficient type.Primary symptom：Side of body rib secret anguish, prolong silk floss endlessly, meet labor and aggravate.Secondary disease：Feverishness in palms and soles, hectic fever night sweat, dry, dizziness, difference of sleeping are more Dream.Tongue vein：Red tongue body, few tongue, stringy,thready and rapid pulse.

3. inclusive criteria：In meeting, the diagnostic criteria of doctor trained in Western medicine chronic cholecystitis.18~70 years old age, male or female.

Clinical treatment

The treatment of principle of reatment cholecystitis according to " symptomatic treatment in acute condition, radical treatment in chronic case " principle.Treatment method is：Soothing the liver profit Courage.Acute cholecystitis is often with clearing away heat and eliminating dampeness, logical internal organs cholagogic method, clearing heat and detoxicating, removing heat by catharsis purges intense heat method treatment；Chronic cholecystitis is conventional to dredge Liver cholagogic, regulating the flow of vital energy Xie Yu method, clearing heat and promoting diuresis, cholagogic lead to internal organs method, dredge sharp liver and gall, Wen Han activates yang method, vital energy regualting and blood circulation-promoting, cholagogic analgesic Method, soothing liver and strengthening spleen, soft liver cholagogic method, Yangyin Rougan liver, the treatment of clearing heat secreting bile method.Chinese traditional treatment target：1. controlling symptom, eliminate scorching Disease；2. shortening the course of disease, recurrence is reduced；3. reduce complication rate.

4. treatment method：Control group：Using traditional oral XIAOYAN LIDAN PIAN, 3 times a day, continuous 30~90 days.Treatment group： Compound Jinsha choleretic granules agent and cholagogic decoction clinical experience prescription composition：15.5 grams of desmodium, 30.5 grams of Asiatic plantain, Lygodium japonicum 15.5 grams of (cloth bag), 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, 15.5 grams of Fructus meliae toosendan, 10.5 grams of rhizoma pinellinae praeparata, rheum officinale (under rear) 10.5 Gram, 10.5 grams of root tuber of aromatic turmeric, 15.5 grams of radix bupleuri, 15.5 grams of radix scutellariae (under rear), 10.5 grams of Fructus Aurantii, 30.5 grams of dandelion.Pain adds under rib 15 grams of radix bupleuri, 10 grams of the root of herbaceous peony；Constipation person increases yellow 5 grams (taking after mixing it with water)；The big person of calculus particle (0.6cm,<In 0.5cm) taking Medicine expectant treatment adds each 10 grams of 20 grams of Asiatic plantain, root tuber of aromatic turmeric, Lygodium japonicum；10 grams of vomiter's addition tuber of pinellia.It is dialectical to control 1. acute gall-bladders Scorching parting opinion controls the hot and suffocating card therapy of (1) courage internal organs：Clearing heat and promoting diuresis, promoting the circulation of qi cholagogic.With reference to《The Treatise on Fevrile Diseases》) plus herbal medicine：Radix bupleuri, it is yellow A kind of reed mentioned in ancient books, rheum officinale (under rear), Fructus Aurantii, rhizoma pinellinae praeparata, oriental wormwood, Asiatic plantain.(2) excessive noxious heat card therapy：Clearing heat and detoxicating, removing heat by catharsis purges intense heat person adds Subtract medicine：Oriental wormwood, rheum officinale, radix scutellariae, dandelion, Asiatic plantain.The parting opinion of 2 chronic cholecystitis controls (1) QI stagnation of the liver and gallbladder card:Therapy： Soothing liver-gallbladder, regulating the flow of vital energy Xie Yu.With reference to《Jing Yue's complete work》Add and subtract medicine：Radix bupleuri, Fructus Aurantii, the root of herbaceous peony, radix scutellariae, Asiatic plantain, root tuber of aromatic turmeric.(2) Syndrome of dampness-heat of liver and gallbladder:Therapy：Clearing heat and promoting diuresis, cholagogic lead to internal organs.With reference to《The collection of prescriptions with notes》Add and subtract medicine：Radix scutellariae, radix bupleuri, Asiatic plantain, greatly Yellow (under rear).It is decocted in water for oral dose, 2 times a day, each 150ml, 15 days are 1 course for the treatment of.It is fine to treat gall stone effect；

5. efficacy assessment standard：This efficacy assessment standard is reference《New Chinese medicine guideline of clinical investigations》Formulate, Specific standards are as follows：1. fully recover：Clinical symptom and sign disappears, and liver function is normal, and courage type-B ultrasonic checks normal, B ultrasound check calculus row Only, without recurrence in 1 year；It is 2. effective：Clinical symptom and sign disappears, and liver function is normal, and courage type-B ultrasonic checks normally, is discharged in stool Calculus, B ultrasound check calculus substantially reduces, without recurrence in half a year；It is 3. effective：Clinical symptom and sign disappears, and total bilirubin increases, liver Courage ultrasound diagnosis prompting courage intracystic stones are present, without recurrence in March；It is invalid：Clinical symptom and sign and auxiliary examination are showed no Turn.

6. treatment results：Two groups for the treatment of results are as shown in table 1：

1 two groups of cure rate tables of comparisons of table

Group	Number of cases	Cure number	Cure rate
				Treatment group	1324	1268	95.77%
Control group	1321	1078	81.60%

Through Chi-square Test, relatively, difference has very significant (P to two groups of effective percentage<0.001).In a word, it is to various calculus Disease is curative for effect, can fossil, row's stone, fundamentally cure lithiasis patient, in especially suitable, old and weak patients, utilize Traditional Chinese medicine composition for treating patient 1324,1292 are as a result cured, effective 56, total effective rate is up to 100%, cure rate 95.77%.Far above the total effective rate of control group 81.60%, and have no toxic side effect.

Model case：

1st, side so-and-so, female 49 years old, Chuan Baixiu streets before Xian Zhu Hubei Province Huang Po, previously with " postcholecystectomy 3 years, upper right Stomachache 3 days " 1, main suit, were admitted to hospital on July 21st, 2010.Patient is before 3 years because gall-bladder and choledocholithiasis are in our hospital's row gall-bladder Excision and Choledocholithotomy, operation is smooth, and post-operative recovery is good, (on July 18th, 2010) burst upper right abdomen pain before 3 days Bitterly, shoulder back is radiated to the right, and the heat that occurs together detests greasy food, and nausea is intended to tell, and it is red that abdominal distension receives poor constipation urine.Have a medical check-up：Mind is clear, Poor, the T of spirit：38.8 DEG C, P：82 beats/min, R：20 beats/min, BP：130/90mmHg sanities, upper right abdomen have one to be about 6cm's Stringer operative incision scar, no visible peristalsis visible intestinal peristalsis, upper right abdomen have tenderness without Blumberg's sign, and Fei Shi signs are not negative, and gurgling sound is normal, blood routine: WBC15.7X 109L,HGB135g/L,PLT：246X 109L, NEUT%0.739；B ultrasound shows：Choledochectasia, diameter is about 1.3cm, the strong echo groups of about 1.1X0.9 of choledochus exit visible one, Echo heterogenicity, rear accompanying sound shadow, probe promotion can activities. Diagnosis：1. choledocholithiasis is with cholangitis；2. after Cholecystectomy And Common Bile Duct Exploration.Oral administered compound Jinsha choleretic granules agent (profit Courage decoction) plus taste：Composition is:15.5 grams of desmodium, 30.5 grams of Asiatic plantain, 15.5 grams of Lygodium japonicum (cloth bag), oriental wormwood 15.5 Gram, 15.5 grams of the root of herbaceous peony, 15.5 grams of Fructus meliae toosendan, 10.5 grams of rhizoma pinellinae praeparata, 10.5 grams of rheum officinale (under rear), 10.5 grams of root tuber of aromatic turmeric, radix bupleuri 15.5 Gram, 15.5 grams of radix scutellariae (under rear), 10.5 grams of Fructus Aurantii, 30.5 grams of dandelion.Daily 1 dose is decocted in water for oral dose, each 250ml, 2 times sooner or later Clothes.Ampicillin, gentamicin, vitamin K1 intravenous infusion 3 days are given simultaneously.Stop remission after 2 days bitterly, take medicine 10 doses, B ultrasound Show：Hepatic duct is slightly expanded, Common Bile Duct Diameter about 1.1cm, without the echo that notes abnormalities, renews 5 doses to consolidate curative effect.After more than 3 years Follow-up is so far without recurrence.

2nd, old XX, female, 46 years old, department：Outer two section, enters to examine in 2010-08-24 days.Admission diagnosis：Cholecystolithiasis；Gall-bladder It is scorching；Choledocholithiasis；Right Knee Trauma is postoperative.Diagnosis and treatment of being admitted to hospital are passed through：Patient aggravated because of upper right abdomen discontinuity pain more than 8 years It is admitted to hospital within two days, PE：T：37.6 DEG C, P：80 beats/min, R：20 beats/min, BP：120/80mmHg sanities, skin, sclera is without Huang Dye, cardiopulmonary inspection is without special.Abdomen put down it is soft, under xiphoid-process and upper right abdomen depth tenderness (+), Blumberg's sign (-).Hepatic region without kowtow pain, liver dullness Boundary is present.Gurgling sound is normal.Cholecystolithiasis is prompted in belly color ultrasound inspection；Gollbladder dilation；Choledochus is broadening；Lower common bile duct knot Stone, liver function test：Glutamic-pyruvic transaminase (ALT), 127 ↑ U/L；Glutamic-oxalacetic transaminease (AST), 64 ↑ U/L；γ glutamyl transpeptidases (GGT), 96 ↑ U/L, T-CHOL (CHOL), 3.38 ↓ mmol/L, aPoA (APOA), 0.98 ↓ g/L.Color ultrasound is prompted：Courage Capsule 58 × 22mm of size, cyst wall thicken, about 6mm, change in double contour sign sample, see the strong light blobs of diameter 0.5mm, rear accompanying sound in it Shadow.Internal diameter of common bile duct 4mm, has no agglomerate echo in it, and slightly strong echo considers hemangioma in liver；Gallbladder wall oedema, cholecystolithiasis； Spleen, pancreas and double kidney no abnormality seens.Oral compound Jin sand choleretic granules agent (original name after being admitted to hospital:Cholagogic decoction) plus taste：Prescription group Turn into:Oral administered compound Jinsha choleretic granules agent (cholagogic decoction) plus taste composition are:15.5 grams of desmodium, Asiatic plantain 30.5 Gram, 15.5 grams of Lygodium japonicum (cloth bag), 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, 15.5 grams of Fructus meliae toosendan, 10.5 grams of rhizoma pinellinae praeparata, rheum officinale (after Under) 10.5 grams, 10.5 grams of root tuber of aromatic turmeric, 15.5 grams of radix bupleuri, 15.5 grams of radix scutellariae (under rear), 10.5 grams of Fructus Aurantii, 30.5 grams of dandelion.Daily 1 dose is decocted in water for oral dose, each 250ml, sooner or later 2 clothes.Simultaneously to giving anti-inflammatory, protect liver and improve coherence check, since taking this hair Bright compound Jinsha choleretic granules agent (original name:Cholagogic decoction) patient's clinical symptoms are relieved after 1 week, symptom after 3 cycles Disappear, continue to take 1 course for the treatment of and consolidate curative effect.Follow-up is so far without recurrence after 3 years.

3rd, Shen XX, female, 18 years old, department：Outer two section, enter to examine on October 25th, 2010.Admission diagnosis：Choledochocyst, Cholecystitis.Diagnosis and treatment of being admitted to hospital are passed through：Patient is admitted to hospital for more than 4 years because of upper right abdomen discontinuity pain, PE：T：37 DEG C, P：80 beats/min, R：20 Beat/min, BP：120/80mmHg (kpa) haves a medical check-up：Sanity, cardiopulmonary inspection is without special.Abdominal muscle is soft, and under xiphoid-process and upper right abdomen is deep Tenderness (+), Blumberg's sign (-).Hepatic region exists without pain, liver dullness circle is kowtowed.Gurgling sound is normal.Liver function test：γ glutamy turns peptide Enzyme (GGT), 130 ↑ U/L；Uric acid (URCA), 129.10 ↓ umol/L；T-CHOL (CHOL), 2.72 ↓ mmol/L；High density fat Albumen (HDL), 0.79 ↓ mmol/L；Low-density lipoprotein courage (LDL), 1.6 ↓ mmol/L.Color ultrasound is prompted：Gallbladder volume form is just Often, gallbladder wall is slightly thick, intracapsular to see that seldom being permitted hot spot accumulates.Choledochus goes out internal diameter 17MM at hepatic portal, stage casing internal diameter 43MM, hypomere Become narrow gradually, internal diameter 8MM, see in choledochus and seldom permitted hot spot, Cystic dilatation bile duct；Finding considers in gall-bladder and choledochus Very small amount silt calculus or courage mud；Liver, spleen, body of pancreas and double kidneys are shown no obvious abnormalities.Given after coherence check is improved after being admitted to hospital With anti-inflammatory symptomatic treatment, patient clinical symptom is relieved.Oral administered compound Jinsha choleretic granules agent (cholagogic decoction)：Composition For:15.5 grams of desmodium, 30.5 grams of Asiatic plantain, 15.5 grams of Lygodium japonicum (cloth bag), 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, Fructus meliae toosendan 15.5 grams, 10.5 grams of rhizoma pinellinae praeparata, 10.5 grams of rheum officinale (under rear), 10.5 grams of root tuber of aromatic turmeric, 15.5 grams of radix bupleuri, 15.5 grams of radix scutellariae (under rear), 10.5 grams of Fructus Aurantii, 30.5 grams of dandelion.Daily 1 dose is decocted in water for oral dose, each 250ml, sooner or later 2 clothes.Simultaneously give to give anti-inflammatory, Protect liver and coherence check is improved, since taking cholagogic decoction of the present invention, symptom is alleviated after 1 week, and symptom disappears after 3 cycles Lose, continue to take 1 course for the treatment of and consolidate curative effect.Follow-up is so far without recurrence after 3 years.

4. Lee XX, female, 63 years old, department：Outer three section, enter to examine on December 13rd, 2011.Admission diagnosis：Cholecystolithiasis；Slowly Property cholecystitis.Diagnosis and treatment of being admitted to hospital are passed through：Patient is admitted to hospital because of " interruption upper right abdominal distention and pain more than 10 years ".The past constitution is fine, and no operation is outer Hinder history and susceptibility history.Have a medical check-up：It is refreshing clear, spirit can, check cooperation, look natural, active posture, sclera is not yellow, and cardiopulmonary are not and bright It is aobvious abnormal.Abdomen equals soft, no tenderness, Blumberg's sign, under liver and spleen rib not and, without pain is kowtowed, gurgling sound is normal in Shuan Shen areas.Four limbs activity can. Outpatient service data：Our hospital's outpatient service B ultrasound shows snail fever liver, cholecystolithiasis.Patient improves after being admitted to hospital and checked, in symptomatic treatment on the 14th, Patient experiences stable disease, recovery can.Color ultrasound is prompted：Gallbladder volume form is normal, and intracapsular to see several strong light blobs, one of them is a diameter of 0.7cm, rear accompanying sound shadow, may move with Body Position Change.Choledochus epimere internal diameter is 0.5cm.Spleen Size form is normal, substantive light Point is evenly distributed, its interior no abnormality seen agglomerate echo.Oral administered compound Jinsha choleretic granules agent (original name:Cholagogic decoction) plus taste prescription Form and be:15.5 grams of desmodium, 30.5 grams of Asiatic plantain, 15.5 grams of Lygodium japonicum (cloth bag), 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, river 15.5 grams of chinaberry, 10.5 grams of rhizoma pinellinae praeparata, 10.5 grams of rheum officinale (under rear), 10.5 grams of root tuber of aromatic turmeric, 15.5 grams of radix bupleuri, radix scutellariae (under rear) 15.5 Gram, 10.5 grams of Fructus Aurantii, 30.5 grams of dandelion.Daily 1 dose is decocted in water for oral dose, each 250ml, sooner or later 2 clothes.Give simultaneously to being resisted Scorching, protect liver and coherence check is improved, take 10 doses of cholagogic decoction of the present invention, symptom is alleviated after 1 week, disease after 2 cycles Shape disappears, and continues to take 10 doses of 1 course for the treatment of cholagogic decoction to consolidate curative effect.Follow-up is so far without recurrence after 2 years.

5. bear XX, man, 63 years old, severe medical science section, entered to examine on April 22nd, 2012.Admission diagnosis：Cholecystolithiasis；Gall-bladder Inflammation, pulmonary tuberculosisDiagnosis and treatment of being admitted to hospital are passed through：Patient does not previously tell specific disease because " cough, expectoration rush gas occur together hot 20 days " is admitted to hospital History.Have a medical check-up：T38 DEG C P100 beats/min, R22 beats/min, BP150/80mmhg sanities, breathe slightly rapid, handsome, double vision Kong Deng great Deng gardens, diameter about 3mm, to light reflection sensitive.Be admitted to hospital and improve coherence check, give it is anti-infective, relieving asthma, eliminating the phlegm, suit the medicine to the illness Treatment.Liver function test：59.8 ↓ g/L of total protein；22.6 ↓ g/L of albumin；72.6 ↑ umol/L of total bilirubin；Bilirubin direct 62.5↑umol/L；63 ↑ U/L of glutamic-pyruvic transaminase；92 ↑ U/L of glutamic-oxalacetic transaminease；334 ↑ U/L of alkaline phosphatase；γ glutamy turns peptide 531 ↑ U/L of enzyme；63.4 ↑ umol/L of total bile acid；1357 ↓ U/L of cholinesterase.Color ultrasound is prompted：Liver section form size is still just Often, substantive luminous point thickening, skewness, stones in intrahepatic bile duct have no obvious expansion, and liver blood pipeline distribution is still clear, see that one is big in liver The small about low echo groups of 10.8 × 7.5cm, border owe clear.Gallbladder volume 6.6 × 2.2cm, it is intracapsular to see several strong light blobs, wherein One a diameter of 0.5cm, rear accompanying sound shadow.Spleen Size form is normal, and substantive luminous point is evenly distributed, and its interior no abnormality seen agglomerate returns Sound.Substantive occupying lesion in liver；Cholecystolithiasis；Seroperitoneum.To giving anti-inflammatory, protect liver and improve coherence check, since clothes It is with oral administered compound Jinsha choleretic granules agent (cholagogic decoction) of the present invention plus taste composition:15.5 grams of desmodium, Asiatic plantain 30.5 grams, 15.5 grams of Lygodium japonicum (cloth bag), 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, 15.5 grams of Fructus meliae toosendan, 10.5 grams of rhizoma pinellinae praeparata, greatly 10.5 grams of yellow (under rear), 10.5 grams of root tuber of aromatic turmeric, 15.5 grams of radix bupleuri, 15.5 grams of radix scutellariae (under rear), 10.5 grams of Fructus Aurantii, dandelion 30.5 Gram.Daily 1 dose is decocted in water for oral dose, each 250ml, sooner or later 2 clothes.Give simultaneously to giving anti-inflammatory, protect liver and improve coherence check, 1 Symptom is alleviated after individual week, and symptom disappears after 3 cycles, continues to take 1 course for the treatment of and consolidates curative effect.After 2 years follow-up so far without Recurrence.

6. Pei XX, female, 43 years old, address：Chuan Baijin streets before yellow pond, suffer from cholecystitis, cholelithiasis more than 5 years, are diagnosed as gall-bladder Scorching, cholelithiasis, medication, does not improve throughout the year.On March 16th, 2011, noon patient was because " upper abdomen has an intense pain, and shiver with cold high fever companion vomits Tell, icteric sclera, expression pain, go to a doctor.Patient's private prosecution, once in the unexpected upper abdomen severe pain of 2 months 19 mornings in 2011, pain Shoulder radiates to the right, and shiver with cold high fever is with vomiting, icteric sclera, expression pain, constipation, yellow and greasy fur, veins string.Cured through Wuhan City 1 Institute's x-ray radiography takes the photograph piece, ultrasound diagnosis is diagnosed as cholecystolithiasis, equal 0.6cmX 13cm.Liver function test：Icterus index 27 is single Position.The unit of glutamic-pyruvic transaminase 106.Card ginseng arteries and veins is examined, this is that liver and gallbladder damp-heat is pented up, and bile is obstructed, gradually into cholelith.Control with soothing the liver profit Courage, logical internal organs, which expels the heat-evil, arranges stone.Oral clinical experience side compound Jinsha choleretic granules agent (original name:Cholagogic decoction), composition is：Gold 15.5 grams of money grass, 30.5 grams of Asiatic plantain, 15.5 grams of Lygodium japonicum (cloth bag), 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, Fructus meliae toosendan 15.5 Gram, 10.5 grams of rhizoma pinellinae praeparata, 10.5 grams of rheum officinale (under rear), 10.5 grams of root tuber of aromatic turmeric, 15.5 grams of radix bupleuri, 15.5 grams of radix scutellariae (under rear), Fructus Aurantii 10.5 grams, 30.5 grams of dandelion.Added and subtracted with disease：Hypochondriac pain severe one, add 10 grams of Fructus meliae toosendan to strengthen the effect of regulating qi-flowing for relieving pain；Stomach is become estranged Drop, symptoms include nausea and vomiting person, we remove the radix scutellariae addition tuber of pinellia with anti-vomiting.Daily 1 dose, decocting 2 times, juice 250ml is taken altogether, point Sooner or later 2 clothes, 1 month is 1 course for the treatment of.10 pairs are even served, fever and chills gradually solve, pain relief, and stool is unimpeded, and icterus index reduces.Enter again 10 pairs, vomiting has stopped, and fever and chills have moved back, and jaundice abatement, tongue fur has moved back, and two is just normal.Continuous 10 pairs of clothes top, discharges mung bean size 5, calculus.15 pairs are taken again, it is normal through the check prompting of function section B ultrasound, have no cholelith light blob, arteries and veins eases up, and all diseases are cured, Since taking clinical experience side's compound Jinsha choleretic granules agent (original name of the present invention:Cholagogic decoction) plus taste, while give to giving Anti-inflammatory, protect liver and coherence check is improved, symptom is alleviated after 1 week of the invention is taken, and symptom disappears after 2 cycles, Continue to take 1 course for the treatment of and consolidate curative effect.Follow-up is so far without recurrence after 3 years.

7th, Hu XX, female, 58 years old, department：Outer three section, it is medical on November 18th, 2011.Situation of being admitted to hospital and diagnosis and treatment are passed through：Suffer from Person is admitted to hospital for about 5 days because being interrupted right Upper abdominal pain discomfort, haves a medical check-up：T：36.3 DEG C, P：80 beats/min, R：19 beats/min, BP：110/ 70mmHg (kpa) god is clear, looks natural, active posture, cooperation of having a medical check-up, sclera is not yellow, and abdomen puts down soft, no tenderness, Blumberg's sign, liver and spleen Under rib not and, without pain is kowtowed, gurgling sound is normal in Shuan Shen areas.Color ultrasound is looked into after being admitted to hospital to show：Cholecystolithiasis；Atrophy of gallbladder, to give anti-inflammatory, Protect liver and improve coherence check symptomatic treatment.Liver function test：Glutamic-pyruvic transaminase, 85U/L.Color ultrasound is prompted：It is intraperitoneal to see largely The strong reecho of gas, hepatic portion image show unclear, remaining liver morphology normal in size, substantive luminous point thickening, are distributed and owe equal It is even, change in ground-glass-like, tube structure is out of shape normal in liver, and rete vasculosum is shown clearly, sees that an a diameter of 0.3cm's is strong in liver Light blob.Gall-bladder is about 3.9 × 1.2cm, intracapsular to see multiple strong light blobs, one of them a diameter of 0.6cm.Gallbladder wall is slightly thick.Courage is total Pipe epimere internal diameter is 0.5cm.Oral administered compound Jinsha choleretic granules agent (original name:Cholagogic decoction) composition is：Desmodium 15.5 Gram, 30.5 grams of Asiatic plantain, 15.5 grams of Lygodium japonicum (cloth bag), 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, 15.5 grams of Fructus meliae toosendan, rhizoma pinellinae praeparata 10.5 grams, 10.5 grams of rheum officinale (under rear), 10.5 grams of root tuber of aromatic turmeric, 15.5 grams of radix bupleuri, 15.5 grams of radix scutellariae (under rear), 10.5 grams of Fructus Aurantii, Pu Public 30.5 grams of English.Daily 1 dose is decocted in water for oral dose, each 250ml, sooner or later 2 clothes.Give simultaneously to giving anti-inflammatory, protect liver and improve phase Close and check, since taking cholagogic decoction of the present invention, symptom is alleviated after 1 week, and symptom disappears after 2 cycles, continues to take 1 The individual course for the treatment of consolidates curative effect.Follow-up is so far without recurrence after 2 years.

8. old XX, female, 59 years old, department：Outer three section, suffers from cholelithiasis more than 12 years, medical on December 8th, 2011.It is admitted to hospital and examines It is disconnected：Suffer from abdominal pain to be checked：CholelithiasisPancreatitisAfter right nephrostomy.Diagnosis and treatment of being admitted to hospital are passed through：Patient has typical clinical symptoms and body Sign, because " more than January, shoulder discharges 3 days intersexuality blood urine to the right with right hypochondrial region " is admitted to hospital.Face of acute ill, breathing are steady, and belly is swollen Grand, soft-fat type, abdomen is soft, upper abdomen tenderness, and there is light percussion pain in You Shen areas, and right lumbar region has a stoma, inside there is the courageous and upright urine of peony Liquid, there is a little blood clot.Gurgling sound is normal.Previously it is diagnosed as：Bronchitis medical history more than 20 years, has hypertension history 10 years, has Gall-bladder stone disease history 10 years, medication, does not improve throughout the year.There are renal insufficiency, cholelithiasis medical history.Blood examination prompting hepatic and renal function is not Entirely.Belly color ultrasound B ultrasound report prompting cholecystolithiasis：For right 0.4~0.6cm of stones in intrahepatic bile duct calculus, atrophy of gallbladder.Given after being admitted to hospital With anti-inflammatory, protect liver and improve coherence check symptomatic treatment.Liver function test：Glutamic-pyruvic transaminase (ALT), 118 ↑ U/L；Millet straw turns ammonia Enzyme (AST), 504 ↑ U/L；Alkaline phosphatase (ALP), 174 ↑ U/L；γ glutamyl transpeptidases (GGT), 248 ↑ U/L；Urea nitrogen (BUN)↑8.8mmol/L；Creatinine (CREA), 227 ↑ umol/L；Sodium (NA), 145.2 ↑ mmol/L；Chlorine (CL), 116.2 ↑ mmol/ L.Color ultrasound is prompted：Gallbladder volume is 6.3 × 2.9cm, intracapsular to see several strong light blobs, rear accompanying sound shadow, and one of major diameter is 2.4cm, choledochus epimere internal diameter are 1.4cm.Lower common bile duct shows unclear.Since taking compound Jinsha choleretic granules of the present invention Agent (cholagogic decoction) composition is：15.5 grams of desmodium, 30.5 grams of Asiatic plantain, 15.5 grams of Lygodium japonicum (cloth bag), oriental wormwood 15.5 Gram, 15.5 grams of the root of herbaceous peony, 15.5 grams of Fructus meliae toosendan, 10.5 grams of rhizoma pinellinae praeparata, 10.5 grams of rheum officinale (under rear), 10.5 grams of root tuber of aromatic turmeric, radix bupleuri 15.5 Gram, 15.5 grams of radix scutellariae (under rear), 10.5 grams of Fructus Aurantii, 30.5 grams of dandelion.Daily 1 dose is decocted in water for oral dose, each 250ml, 2 times sooner or later Clothes.Give simultaneously to giving anti-inflammatory, protect liver and improve coherence check, symptom is alleviated after 30 days, and symptom disappears after 2 months, Continue to take 2 courses for the treatment of and consolidate curative effect.Regular further consultation accuses recovery from illness without recurrence after 2 years.

9th, medical record citing wishes certain, female, 38 years old.Department：An outer section, now firmly Wuhan economic cycle Pan Jia fields cell, is the court Nurses of Emergency Department is grown, and on 2 24th, 2012 patients are admitted to hospital because of " interruption pain over the chest and back companion's vomiting in 1 year 1 day ".2. present illness history：Patient tells 1 There is pain over the chest and back in the obvious inducements of Nian Qianwu, are paroxysmal pain.With vomiting, vomitus is gastric content and swill.Without sour regurgitation, Belch.Without stomachache, diarrhoea.Without heating, cough, expectoration.Nothing is nervous, uncomfortable in chest, pectoralgia is uncomfortable.Past medical history：Upper right abdomen was felt before half a year There is pain during portion with abdominal distension, and be radiated to shoulder, more violent during panic attacks, injection Sauteralgyl can not still stop, and with the soreness of waist.Through The Color B-Type Ultrasonic inspection of function section is diagnosed as chronic cholecystitis, courage intracystic stones.Today, right Upper abdominal pain broke out again, and patient refuses hand Art, turn the treatment that takes traditional Chinese medicine.Card category damp-heat accumulation, liver and gall are lost in catharsis, are polymerized to calculus.Control plan dispersing stagnated hepatoqi, clearing away heat and eliminating dampeness cholagogic. Start to take this patent clinical experience side the agent of compound Jinsha choleretic granules (cholagogic decoction) composition be：15 grams of desmodium, car First careless 30 grams, 20.5 grams of Lygodium japonicum (cloth bag), 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, 15.5 grams of Fructus meliae toosendan, 10.5 grams of rhizoma pinellinae praeparata, 10.5 grams of rheum officinale (under rear), 10.5 grams of root tuber of aromatic turmeric, 15.5 grams of radix bupleuri, 15.5 grams of radix scutellariae, 10.5 grams of Fructus Aurantii, 30.5 grams of dandelion.Often 1 dose of day is decocted in water for oral dose, each 150ml, sooner or later 2 clothes.Give simultaneously to giving anti-inflammatory, protect liver and improve coherence check, take 10 Fu Hou, right Upper abdominal pain have been removed, stool day row 4 times, half congealed rotten, and 3 pieces of thunder eggs as large as soya bean are found in stool.Original side is gone Except rheum officinale, continuous to take 5 pairs, all diseases are removed, and enter 15 pairs again, as a means of consolidation.Follow-up so far there are no within 2 years recurrence.

10th, XX is opened, man, 68 years old, department：An outer section, suffers from cholelithiasis more than 15 years, is diagnosed as cholelithiasis, and medication, has no throughout the year Take a turn for the better.Pathological characteristics：1. patient main suit：On December 27th, 2012, because of " Upper abdominal pain more than 7 hours in right ", recurrence is admitted to hospital again, Now live the yellow Li Qiaoyandi villages of pond three；2. present illness history：There is Upper abdominal pain in the right side, companion about being satiated with food when afternoon about 3 in patient's this morning Vomiting and heating, no spitting blood is uncomfortable in chest and suffers from diarrhoea.Once in the hospital admission row coherence check of Wuhan 161, not row treatment, its abdomen after morbidity Pain is without alleviation.Patient is existing to our hospital, and outpatient service is taken in me with " acute cholecystitis, cholecystolithiasis, choledocholithiasis " and section treated. 3. past medical history：Previously there are the medical histories such as cholecystolithiasis, pulmonary emphysema, dyshepatia, deny drug allergy history.4. physical examination：Enter 40 DEG C of institute's body temperature, pulse 98 beats/min (irregular), breathe 20 beats/min (rules), blood pressure 110/70mmHg.Row is related after being admitted to hospital Check, MRI shows：Choledochus stage casing calculus, gall-bladder Calculus, cholecystitis (fossa of gallbladder oedema) rabat show：Chronic bronchitis, Pulmonary emphysema, PFT show：Severe is limited in respiratory disorder, and anti-infective, the symptomatic treatment of row informs family members' risk, and family members require to protect Keep treatment.Admission diagnosis：Acute cholecystitis, choledocholithiasis, cholecystolithiasis, acute cholangitis, pulmonary emphysema, dyshepatia. 5. auxiliary examination：PFT shows：Severe obstruction of pulmonary ventilation, rabat show：Slow Zhi Yan, pulmonary emphysema, aortic knob calcification, biliary tract MRI shows：Choledochus stage casing calculus, gall-bladder Calculus, cholecystitis, pulmonary dysfunction, modern to ask Respiratory Medicine consultation of doctors treatment at present, Treatment is the same.Take this patent clinical experience side compound Jinsha choleretic granules agent (original name:Cholagogic decoction) composition is：Money 15.5 grams of grass, 30.5 grams of Asiatic plantain, 15.5 grams of Lygodium japonicum (cloth bag), 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, 15.5 grams of Fructus meliae toosendan, 10.5 grams of rhizoma pinellinae praeparata, 10.5 grams of rheum officinale (under rear), 10.5 grams of root tuber of aromatic turmeric, 15.5 grams of radix bupleuri, 15.5 grams of radix scutellariae (under rear), Fructus Aurantii 10.5 Gram, 30.5 grams of dandelion.Daily 1 dose is decocted in water for oral dose, each 250ml, sooner or later 2 clothes.Give simultaneously to giving anti-inflammatory, protect liver and complete Kind coherence check color ultrasounds are shown：Liver morphology is normal, and signal change is shown no obvious abnormalities in liver parenchyma；Stones in intrahepatic bile duct has no bright Aobvious expansion；Choledochus is slightly expanded, the visible size in choledochus stage casing about 1.2 × 1.3cm nodositas T2WI low signals；Gall-bladder increases, Cyst wall thickens.Choledochus stage casing calculus；Gall-bladder Calculus, cholecystitis (fossa of gallbladder oedema).Medication：27/12 0.9% chlorination Sodium pin 250ml, Cefodizime pin skin test, 8/1 compound Jinsha choleretic granules (original name：Cholagogic decoction) × 15 pairs, 27,/12 0.9% Sodium chloride pin 100ml, Cefodizime pin 2.0g, 0.5% first nitre support pin 200ml, 0.9% sodium chloride pin 100ml, Pantoprazole pin 60mg, 0.9% sodium chloride pin 250ml, diammonium glycyrrhizinate pin 150mg, 0.9% sodium chloride pin 100ml, dimension K 20mg.Discharge instructions：Clearly Light liquid diet, uncomfortable follow-up, symptom is alleviated after cholagogic decoction of the present invention 15 days is taken, and symptom disappears after 3 courses for the treatment of Lose, continue to take 3 courses for the treatment of and consolidate curative effect.More than a year after follow-up so far there are no recurrence.

11st, Shi, women, 69 years old, department：An outer section, accounting, body are preferable.Address：The double Qing in Huangpo District Qian Chuan streets Garden cell, on April 26th, 2011 noon patient " be radiated to shoulder back, abdominal fullness and distention because of right side side of body rib portion pain, then send out 1 day " enter Institute.Past medical history：Cholecystolithiasis and cholecystitis 7 years, take compound bear gall acid piece, do not improve throughout the year.Come within 1 week because of tired, edible oil Recur after greasy food, aggravated by disease again, it is in great pain.Above-mentioned symptom significantly aggravates after sulky, in great pain after recurrence, companion Vexed, mood is not very good, annual to recur 2 times.Have a medical check-up：It can be laid one's hand under right rib and the gall-bladder of enlargement, tenderness under the right rib of limitation, without anti- Jump pain, right side side of body rib position percussion pain.Red tongue body, yellow tongue fur is slightly greasy, veins string and it is tight.Color ultrasound ultrasound diagnosis is shown：Gall-bladder slightly enlargement, it is long Footpath 8.5cm, transverse diameter 5cm, it is gall-bladder wall thickness, crude in multiple 0.3~0.5cm of gall stone.Liver function：Glutamic-pyruvic transaminase 58umol/ L, total bilirubin 26umol/L, bilirubin direct 19umol/L, indirect bilirubin 9umol/L.Blood routine：Leucocyte 11.3X109/L, neutrality 75.6%, once treated with gall stone and cholecystitis.With 6 grams of drip-feeds of ampicillin sodium, daily 2 It is secondary, anisodamine 10mg, 2 times a day, the symptomatic treatment such as intramuscular injection can only pain of alleviation, unstable condition.The traditional Chinese medical science thinks：Side of body rib is Position where liver and gall, the disease of side of body rib, category liver and gall two pass through, and this onset of disease is mostly the stagnation of the circulation of vital energy, and in continuation distending pain, paroxysmal adds sometimes It is acute.The stagnation of the circulation of vital energy is obstructed, and Gong, which is altered, has a pain, therefore tug and the right side shoulder back of the body.Irritability stasis, influences taste, the dysfunction of the spleen in transport, and stomach loses logical drop, occurred Abdominal fullness and distention, nausea, difference of receiving are weak.With the passing of time symptom, the stagnation of the circulation of vital energys such as liver depression forming fire, then bitter taste, dark urine, low-heat, cause blood stasis, There is the pain tug of right side side of body rib portion and shoulder back.Sign：Right flank flank has slight percussion pain, can lay one's hand on and the gall-bladder of enlargement, tenderness Limitation is fixed.Therapy：Dispersing stagnated hepatoqi, stagnation resolvation row's stone, removes obstruction in channels to relieve pain.Since taking compound Jinsha cholagogic in clinical experience side's of the present invention Granule (original name:Cholagogic decoction) plus taste composition be:15.5 grams of desmodium, 30.5 grams of Asiatic plantain, Lygodium japonicum (cloth bag) 20.5 grams, 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, 15.5 grams of Fructus meliae toosendan, 10.5 grams of rhizoma pinellinae praeparata, 10.5 grams of rheum officinale (under rear), root tuber of aromatic turmeric 10.5 grams, 15.5 grams of radix bupleuri, 15.5 grams of radix scutellariae (under rear), 10.5 grams of Fructus Aurantii, 30.5 grams of dandelion.Daily 1 dose is taken, every time 250ml, 2 clothes of morning and evening.It even served 10 pairs.Give simultaneously to giving anti-inflammatory, protect liver and improve coherence check, side of body rib portion on the right side of patient Pain is radiated to shoulder back, abdominal distension, belch, and the poor symptom such as weak, bitter taste, dark urine of receiving subtracts greatly, appetite increase.Imitate not more Method, then keep 15 pairs of original side, right side side of body rib portion tenderness, percussion pain disappear, gall-bladder do not lay one's hand on and, spiritual appetite is good.Blood routine is normal.B It is super to show：Gallbladder volume is normal, and calculus reduces 70% compared with preceding.Liver function：Glutamic-pyruvic transaminase, total bilirubin, bilirubin direct Normally.To giving anti-inflammatory, protect liver and improve coherence check, since taking compound Jinsha choleretic granules agent of the present invention, (cholagogic is decocted Agent), symptom is alleviated after 1 week, and symptom disappears after 3 cycles, continues to take 1 course for the treatment of and consolidates curative effect.Follow-up is extremely after 3 years The present is without recurrence.

12nd, Peng XX, man, 70 years old, department：An outer section, address：Yellow Po Qianchuanpeng buildings village, suffers from cholelithiasis more than 25 years, diagnosis For cholelithiasis, medication, does not improve always throughout the year.On December 28th, 2013, patient is because of " the interventral disconnected pain of upper right more than 1 year, then send out 1 day " it is admitted to hospital.Enter gate (urgency) diagnosis：Acute episode of chronic cholecystitis, cholecystolithiasis, acute pancreatitisHigh blood pressure.Look into Body：Physical examination：37 DEG C of body temperature, pulse 82 beats/min (rules), breathe 20 beats/min (rules), blood pressure 180/100mmHg.It is admitted to hospital Date：On December 28th, 2013, leave hospital the date：On 01 02nd, 2014.Diagnosis and treatment of being admitted to hospital are passed through：Patient is because of " the interventral disconnected pain of upper right More than 1 year bitterly, then send out 1 day " be admitted to hospital.Pathological characteristics：1. main suit：The interventral disconnected pain of upper right more than 1 year, then send out 1 day；2. present illness history：Suffer from There is right Upper abdominal pain, and interruption breaking-out repeatedly before 1 year without obvious inducement in person.Previously once row abdominal B-scan ultrasonography inspection prompting gall-bladder knot Stone.Give anti-inflammatory analgesic symptomatic treatment during morbidity, stomachache can take a turn for the better.Patient sends out the right side again without obvious inducement about during this morning about 1 Upper abdominal pain, no heating vomiting and jaundice, without uncomfortable in chest and diarrhoea.Once in Huang Po belts commune hospital, row anti-inflammatory analgesic is suited the medicine to the illness after morbidity Treatment, stomachache are not relieved.Patient is existing to our hospital, and outpatient service is taken in " acute episode of chronic cholecystitis, cholecystolithiasis " My section treats.After patient this time falls ill, spiritual diet and poor sleep, stool and urine Non Apparent Abnormality.3. past medical history：Previously there is height Blood pressure medical history once has stroke history before more than 4 years, 2 years.Deny drug allergy history.5. training inspection：Refreshing clear, sclera is not yellow, the heart Lung (-), abdomen put down it is soft, it is right in upper abdomen tenderness (+), no Blumberg's sign, not Fei Shi levy (+), under liver and spleen rib not and, gurgling sound is normal, double Kidney area without kowtow pain, Yu Zheng.6. auxiliary examination：1 part of the belt commune hospital of Huangpo District on December 28 in 2013 discharge record.Discriminating is examined It is disconnected：Gastric ulcer：Left Upper abdominal pain, there is sour regurgitation situation, and gastrocopy can be clear and definite.Diagnosis and treatment plan：Prohibit diet, give anti-inflammatory analgesic Supportive treatment of suiting the medicine to the illness is depressured, improves belly color ultrasound and blood biochemical coherence check, observes vital sign and change of illness state.Color ultrasound institute Show：Gallbladder volume about 8.1 × 3.2cm, form is normal, intracapsular to see the strong light blobs of diameter about 0.5cm, rear accompanying sound shadow, intracapsular see also glutinous Thick thick luminous point.Choledochus epimere internal diameter about 0.6cm.Ultrasound prompting：The a large amount of pneumatosis in abdominal cavity；Cholecystolithiasis, bile are sticky；Double kidney knots Stone.Medication：2013.12.28 0.9% sodium chloride pin 250ml, Cefodizime pin, 2014.1.1 take clinical experience side of the present invention Compound Jinsha choleretic granules agent (original name:Cholagogic decoction) × 10 pairs, composition is:15.5 grams of desmodium, 30.5 grams of Asiatic plantain, 15.5 grams of Lygodium japonicum (cloth bag), 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, 15.5 grams of Fructus meliae toosendan, 10.5 grams of rhizoma pinellinae praeparata, rheum officinale (under rear) 10.5 grams, 10.5 grams of root tuber of aromatic turmeric, 15.5 grams of radix bupleuri, 15.5 grams of radix scutellariae (under rear), 10.5 grams of Fructus Aurantii, 30.5 grams of dandelion.Daily 1 dose Take, each 250ml, sooner or later 2 clothes.It even served 15 pairs.Give to giving anti-inflammatory, protect liver and improve coherence check, leave hospital simultaneously Doctor's advice：Take a good rest, low fat diet, uncomfortable follow-up.Patient is since taking compound Jinsha choleretic granules agent (original name of the present invention:Profit Courage decoction), symptom is alleviated after 1 cycle, and symptom disappears after 2 cycles, continues to take 1 course for the treatment of and consolidates curative effect.Half a year Follow-up is without recurrence afterwards.

13rd, XX is opened, man, 68 years old, department：An outer section, address：The yellow Li Qiaoyandi villages of pond three, 1. admission dates：2013 May 27, patient is because " Upper abdominal pain more than 7 hours in right " is admitted to hospital, door (urgency) diagnosis：Acute cholecystitis, choledocholithiasis, courage Capsule calculus, acute cholangitis, pulmonary emphysema.Row coherence check after being admitted to hospital, 40 DEG C of body temperature, pulse 98 beats/min (irregular), breathing 20 Beat/min (rule), blood pressure 110/70mmHg.MRI shows：Choledochus stage casing calculus, gall-bladder Calculus, cholecystitis (fossa of gallbladder water It is swollen) rabat shows：Chronic bronchitis, pulmonary emphysema, PFT show：Severe is limited in respiratory disorder, anti-infective, the symptomatic treatment of row, Family members' risk is informed, family members require expectant treatment.2. present illness history：Patient's this morning occurs about being satiated with food when afternoon about 3 in the right side Abdomen pain, with vomiting and heating, no spitting blood is uncomfortable in chest and suffers from diarrhoea.Once do not gone in the hospital admission row coherence check of Wuhan 161 after morbidity Treatment, it is suffered from abdominal pain without alleviation.Patient is existing to our hospital, and outpatient service is taken in " acute cholecystitis, cholecystolithiasis, choledocholithiasis " My section treats.After morbidity, spiritual diet and poor, stool and urine Non Apparent Abnormality of sleeping.3. past medical history：Previously without specific disease History, deny drug allergy history.4. training inspection：Refreshing clear, breathing is steady, skin and sclera slightly xanthochromia, cardiopulmonary (-), abdomen put down it is soft, Upper abdomen tenderness (+) in the right side, no Blumberg's sign, not Fei Shi levy (+), under liver and spleen rib not and, hypoactive bowel sounds, Shuan Shen areas are remaining without kowtowing pain Just.5. auxiliary examination：On December 27th, 2013 161 hospital abdominal CT prompting distal common bile duct calculus of Wuhan, choledochectasia, courage Capsulitis and cholecystolithiasis, the multiple pneumatosis of stones in intrahepatic bile duct, left kidney microlith, double lung pulmonary emphysema.Previously without special medical history, deny medicine Allergies.Blood routine prompting WBC12.65 × 10 9./L, N97.0%.Blood amylase and lipase are normal.Diagnosis and treatment plan：Prohibit drink Food, give anti-inflammatory analgesic protect liver of bringing down a fever and suit the medicine to the illness supportive treatment, improve blood biochemical coherence check, observe vital sign and the state of an illness becomes Change.PFT shows：Severe obstruction of pulmonary ventilation, rabat show：Slow Zhi Yan, pulmonary emphysema, aortic knob calcification, biliary tract MRI show：Courage House steward stage casing calculus, gall-bladder Calculus, cholecystitis, pulmonary dysfunction, modern to ask Respiratory Medicine treatment at present, treats the same.It is color Super display：Liver morphology is normal, and signal change is shown no obvious abnormalities in liver parenchyma；Stones in intrahepatic bile duct has no obvious expansion；Choledochus Slightly expand, the visible size in choledochus stage casing about 1.0 × 0.6cm nodositas T2WI low signals；Gall-bladder increases, and cyst wall thickens.Courage is total Pipe stage casing calculus；Gall-bladder Calculus, cholecystitis (fossa of gallbladder oedema) doctor trained in Western medicine are diagnosed as calculus of bile duct, and tcm diagnosis is hypochondriac pain, Disease belongs to damp-heat type.Rules for the treatment of heat-clearing is soothing the liver, invigorating gallbladder and removing gall-stone.Medication：27/12 0.9% sodium chloride pin 250ml, Cefodizime pin skin Examination, 8/1 compound Jinsha choleretic granules (original name：Cholagogic decoction × 15 pair), 27/120.9% sodium chloride pin 100ml, Cefodizime Pin 2.0g, 0.5% first nitre support pin 200ml, 0.9% sodium chloride pin 100ml, Pantoprazole pin 60mg, 0.9% sodium chloride pin 250ml, diammonium glycyrrhizinate pin 150mg, 0.9% sodium chloride pin 100ml, dimension K 20mg.(special examined is numbered：X-ray number：1350389CT Number：/ No. WEI：1317621) discharge instructions：Bland liquid diet, uncomfortable follow-up, since taking compound Jinsha cholagogic of the present invention Grain (original name：Cholagogic decoction) composition is：15.5 grams of desmodium, 30.5 grams of Asiatic plantain, 15.5 grams of Lygodium japonicum (cloth bag), oriental wormwood 15.5 grams, 15.5 grams of the root of herbaceous peony, 15.5 grams of Fructus meliae toosendan, 10.5 grams of rhizoma pinellinae praeparata, 10.5 grams of rheum officinale (under rear), 10.5 grams of root tuber of aromatic turmeric, radix bupleuri 15.5 grams, 15.5 grams of radix scutellariae (under rear), 10.5 grams of Fructus Aurantii, 30.5 grams of dandelion.Daily 1 dose is taken, each 250ml, 2 times sooner or later Clothes.Symptom is alleviated after 15 days, and symptom disappears after 3 courses for the treatment of, continues to take 3 courses for the treatment of and consolidates curative effect.Follow-up after more than a year Recurrence that so far there are no.

14th, Wu XX, female, 70 years old, department：An outer section, Xian Zhu Hubei Province Huang Po Cai Dian streets source village, on 01 12nd, 2013 Patient is because of " upper abdomen pain 2 days." be admitted to hospital.1st, previously there is glaucoma and blind for many years, colitis medical history for many years, denies that operation is outer Hinder history, blood transfusion history, medicine food hypersenstivity history, deny hepatitis, blood fluke medical history.Row fluid infusion, anti-infective, symptomatic treatment.2nd, existing disease History：Patient, without obvious inducement sense upper abdomen pain, with vomiting once, was gastric content, and non-ejection shape, with chilly, sent out before 2 days Heat, without stupor, uncomfortable in chest, cough, shortness of breath, melena, once in local row infusion treatment, no improvement, sought medical advice to our hospital, suffer from abdominal pain and wait to check and accept It is admitted to hospital.Leave hospital the date：On 01 15th, 2014.3rd, admission diagnosis：Suffer from abdominal pain to be checked, acute cholecystitis, acute pancreatitisLeft kidney knot Stone.4. physical examination：36.8 DEG C of body temperature, pulse 86 beats/min (rules), breathe 20 beats/min (rules), blood pressure 140/70mmHg god Clearly, neck is soft, and cardiopulmonary are without exception, and abdomen is put down soft, and upper abdomen tenderness, no Blumberg's sign, gurgling sound is weak, and double lower limb is without swelling；5. training is examined Look into：Refreshing clear, neck is soft, and cardiopulmonary are without exception, and upper abdomen tenderness, no Blumberg's sign, gurgling sound is weak, and double lower limb is without swelling.6. auxiliary examination： Electrocardio illustrates：Sinus rhythm, QT interval prolongations, color ultrasound are shown：Gall-bladder increases, the left slight hydrops of kidney, and courage assists calculus, abdominal aorta coloured silk It is super to show：Abdominal aorta can display segment atherosclerosis plaque forming.7th, liver function test：Patient tells that stomachache slightly mitigates, and vomiting is stomach once Content, non-ejection shape, physical examination is the same, and blood routine shows just now：Leucocyte etc. shows abnormal, and heart infarction three, myocardial enzymes are normal. Director Zhu indicates after checking patient：Patient presently, there are obstructive jaundice, enteric infection, liver function damage, and hypopotassaemia is provisional Symptomatic treatment, row biliary tract MRCP are checked.8th, color ultrasound is prompted：Abdominal aorta can display segment inner membrance it is rough, tube wall is slightly thick, in tube chamber Footpath 1.6cm, see and be dispersed in strong hot spot attachment, color Doppler shows that blood flow is continuous whole in tube chamber, regular edges, had no in it Abnormal blood flow signal.Pneumoperitoneum portion segment shows unclear.9th, medication：27/12 0.9% sodium chloride pin 250ml, cephalo Piperazine pin 1g, 15/1 (skin test is qualified), 8/1 oral administered compound Jinsha choleretic granules (original name：Cholagogic decoction × 15 pair) composition is： 15.5 grams of desmodium, 30.5 grams of Asiatic plantain, 15.5 grams of Lygodium japonicum (cloth bag), 15.5 grams of oriental wormwood, 15.5 grams of the root of herbaceous peony, Fructus meliae toosendan 15.5 Gram, 10.5 grams of rhizoma pinellinae praeparata, 10.5 grams of rheum officinale (under rear), 10.5 grams of root tuber of aromatic turmeric, 15.5 grams of radix bupleuri, 15.5 grams of radix scutellariae (under rear), Fructus Aurantii 10.5 grams, 30.5 grams of dandelion.Daily 1 dose is taken, each 250ml, sooner or later 2 clothes.27/12 0.9% sodium chloride pin 100ml, Cefodizime pin 2.0g, 0.5% first nitre support pin 200ml, 0.9% sodium chloride pin 100ml, Pantoprazole pin 60mg, 0.9% chlorination Sodium pin 250ml, diammonium glycyrrhizinate pin 150mg, 0.9% sodium chloride pin 100ml, dimension K 20mg.Continuous to take 15 doses, all diseases are removed, and enter 5 again Pay, as a means of consolidation.Symptom is alleviated after 35 doses of cholagogic decoction of the present invention is taken, and symptom disappears after 3 courses for the treatment of, continues to take Consolidate curative effect with 3 courses for the treatment of.More than 1 year after follow-up check belly and urinary system color ultrasound so far there are no recurrence.

Enlarged experiment prepares embodiment

Embodiment 1：15.5 kilograms of desmodium, 30.5 kilograms of Asiatic plantain, 15.5 kilograms of Lygodium japonicum (cloth bag), oriental wormwood 15.5 thousand Gram, 15.5 kilograms of the root of herbaceous peony, 155 kilograms of Fructus meliae toosendan, 10.5 kilograms of rhizoma pinellinae praeparata, 10.5 kilograms of rheum officinale (under rear), 10.5 kilograms of root tuber of aromatic turmeric, 15.5 kilograms of radix bupleuri, 15.5 kilograms of radix scutellariae (under rear), 10.5 kilograms of Fructus Aurantii, 30.5 kilograms of dandelion；Wherein granule preparation side Method is：

The outer 11 taste medicinal materials of rheum officinale, radix scutellariae are removed, add 10-15 times of water, after soaking 20-40 minutes, heating extraction, extract 2-4 It is secondary, decoct every time 0.5-2 hours, radix scutellariae adds extraction when extracting for the 2nd time under 70 DEG C of conditions above after immersion treatment 0.5-2h is optimised process, merges extract solution, filtration, it is standby to be concentrated into the thick paste that 25 DEG C of density are 1.20g/ml；Rheum officinale crushes It is standby to cross 100 mesh sieves；Dried cream powder is mixed and made into 12 kinds of medicinal extract to feed intake, it is 1.5 separately to take dextrin and galactose ratio:1, equal increments Method is well mixed, and adds 0.5% Aspartame, raw material, auxiliary material are well mixed, are made using 75% ethanol as diluent soft Material, thick paste and auxiliary material 1:2.5 ratio mixing, with 12 mesh sieve wet granulations, less than 80 DEG C fully dryings, whole grain, pack and produce, Produce finished particle agent of the present invention.

Embodiment 2：The preparation method of tablet is：

Remove the outer 11 taste medicinal materials of rheum officinale, radix scutellariae:15.5 kilograms of desmodium, 30.5 kilograms of Asiatic plantain, Lygodium japonicum (cloth bag) 15.5 kilograms, 15.5 kilograms of oriental wormwood, 15.5 kilograms of the root of herbaceous peony, 155 kilograms of Fructus meliae toosendan, 10.5 kilograms of rhizoma pinellinae praeparata, rheum officinale (under rear) 10.5 kilograms, 10.5 kilograms of root tuber of aromatic turmeric, 15.5 kilograms of radix bupleuri, 15.5 kilograms of radix scutellariae (under rear), 10.5 kilograms of Fructus Aurantii, dandelion 30.5 Kilogram；Add 10-15 times of water, after soaking 20-40 minutes, heating extraction, extract 2-4 times, decoct 0.5-2 hours every time, radix scutellariae exists It is optimised process that extraction 0.5-2h is added during the 2nd extraction, and under 70 DEG C of conditions above after immersion treatment, merges extract solution, Filtration, the thick paste that 25 DEG C of density are 1.20g/ml is concentrated into, it is standby that rheum officinale crushed 100 mesh sieves；It is mixed with 12 kinds of medicinal extract Dried cream powder feeds intake, and it is 1.5 separately to take dextrin and galactose ratio:1, equal increments method is well mixed, and adds 0.5% Aspartame, will Raw material, auxiliary material are well mixed, and softwood, thick paste and auxiliary material 1 are made using 75% ethanol as diluent:2.5 ratio mixing, is used 12 mesh sieve wet granulations, less than 80 DEG C are fully dried, and tabletting, produce finished tablet of the present invention.

Embodiment 3：The preparation method of capsule is：

Remove outer 11 15 kilograms of the taste medicinal material desmodiums of rheum officinale, radix scutellariae, 30 kilograms of Asiatic plantain, 30 kilograms of Lygodium japonicum (cloth bag), 15 kilograms of oriental wormwood, 15 kilograms of the root of herbaceous peony, 15 kilograms of Fructus meliae toosendan, 10 kilograms of rhizoma pinellinae praeparata, 10 kilograms of rheum officinale (under rear), 10 kilograms of root tuber of aromatic turmeric, 15 kilograms of radix bupleuri, 15 kilograms of radix scutellariae, 10 kilograms of Fructus Aurantii, 30 kilograms of dandelion, add 10-15 times of water, after soaking 20-40 minutes, add Heat extraction, is extracted 2-4 time, is decocted every time 0.5-2 hours, and radix scutellariae is in the 2nd extraction, and under 70 DEG C of conditions above at immersion It is optimised process that extraction 0.5-2h is added after reason, merges extract solution, filtration, is concentrated into the thick paste that 25 DEG C of density are 1.20g/ml, It is standby that rheum officinale crushed 100 mesh sieves；Dried cream powder is mixed and made into 12 kinds of medicinal extract to feed intake, it is 1.5 separately to take dextrin and galactose ratio:1, Equal increments method is well mixed, and adds 0.5% Aspartame, raw material, auxiliary material are well mixed, and dilution is used as using 75% ethanol Softwood, thick paste and auxiliary material 1 is made in agent:2.5 ratio mixing, with 12 mesh sieves granulation wet granulation, 80 DEG C of drying, whole grain, add Lubricant, it is encapsulated, produce finished capsule product agent of the present invention.

Embodiment 4：Take 15 kilograms of desmodium, 30 kilograms of Asiatic plantain, 30 kilograms of Lygodium japonicum (cloth bag), 15 kilograms of oriental wormwood, in vain 15 kilograms of Chinese herbaceous peony, 15 kilograms of Fructus meliae toosendan, 10 kilograms of rhizoma pinellinae praeparata, 10 kilograms of rheum officinale (under rear), 10 kilograms of root tuber of aromatic turmeric, 15 kilograms of radix bupleuri are yellow 15 kilograms of a kind of reed mentioned in ancient books, 10 kilograms of Fructus Aurantii, 30 kilograms of dandelion.Fully mix, soak 45 minutes, in extractor boiling twice, Continue boiling 60 minutes after boiling every time, merge filtrate twice, quiescent setting 10 hours, take supernatant boiling to be concentrated into 500L, It is distributed into bottle；Then moise-heat sterilization 30 minutes, finished product decoction as of the present invention.Instructions of taking：Daily 500ml, takes at twice.

Compound Jinsha choleretic granules agent acute toxicity testing and pharmacodynamic study:

Drug safety is made an appraisal according to wherein process for producing granula：

Acute toxicity testing and pharmacodynamic study:Toxicological study is made an appraisal for Drug safety, is divided into acute Toxicity test and long term toxicity test.The research purpose of animal acute toxicity experiment mainly have illustrate medicine toxic action, Solve its toxicity target organ, long term toxicity test dosage refers to, the design considerations of the dosage of pharmacodynamic study and clinical trial originate The reference of dosage.This chapter observes dealed with medicine went, and be the agent of pharmacodynamic experiment by the investigation to acute toxicity testing Amount design provides reference frame.A kind of Chinese medicine composition compound Jinsha choleretic granules agent composition of the present invention is:Desmodium 15 Gram, 30 grams of Asiatic plantain, 30 grams of Lygodium japonicum, 15 grams of oriental wormwood, 15 grams of the root of herbaceous peony, 15 grams of Fructus meliae toosendan, 10 grams of rhizoma pinellinae praeparata, rheum officinale (under rear) 10 Gram, 10 grams of root tuber of aromatic turmeric, 15 grams of radix bupleuri, 15 grams of radix scutellariae, 10 grams of Fructus Aurantii, 30 grams of dandelion.Remove the outer 11 taste medicinal materials of rheum officinale and add 10-15 times Water, soak 20-40 minutes after, heating extraction, extract 2-4 time, every time decoct 0.5-2 hours, radix scutellariae the 2nd time extraction when, and It is optimised process to add extraction 0.5-2h after immersion treatment under 70 DEG C of conditions above, merges extract solution, filtration, is concentrated into 25 DEG C Density is that 1.20g/ml thick paste is standby；It is standby that rheum officinale crushed 100 mesh sieves, is mixed and made into dried cream powder with 12 kinds of medicinal extract and feeds intake, It is another to take dextrin and galactose ratio as 1.5:1, equal increments method is well mixed, and adds 0.5% Aspartame, and by raw material, auxiliary material It is well mixed, softwood, thick paste and auxiliary material 1 are made using 75% ethanol as diluent:2.5 ratio mixing, with 12 mesh sieve series Grain wet granulation, 80 DEG C of drying, whole grain produce.

This problem prescription is clinical experience side for many years in institute of Huangpo District the People's Hospital, in terms for the treatment of cholelithiasis and cholecystitis It is curative for effect.Motherland's medical science thinks that cholelithiasis belongs to the traditional Chinese medical science " hypochondriac pain " " accumulation of pathogens in chest ", and " jaundice " waits disease category.The formation of cholelithiasis, It is because of irritability stasis, bile is lost in catharsis, and shaoyang channel arteries and veins is unfavorable, strongly fragrant and change fire or addiction delicious food, and product humidogene heat is burning hot stifling, Bile is decocted, poly- and give birth to stone, courage network is hindered, and general rule pain is not so that hypochondriac pain receives difference, notably jaundice.Therefore cholelithiasis is with wet, hot, silt Three evil intertextures is suffer from, disease located in liver courage, the real example of state of an illness category stagnation of liver qi.Therefore treatment is with dispersing stagnated hepatoqi, clearing heat and promoting diuresis, cholagogic Arrange based on stone.Therefore this chapter investigates from antiinflammation and choleretic effect to compound Jinsha choleretic granules.

Compound Jinsha choleretic granules agent acute toxicity testing

1.1 experimental animal

SPF levels Kunming kind healthy mice 60, male and female half and half, body weight 18-22g, by Hubei Province Animal Experimental Study center There is provided, credit number：SCXK (Hubei Province) 2008-0005, animal quality certification number：42000600002761；42000600002865.Institute Have before zoopery after HuaZhong Science University, TongJi medical school, TongJi Hospital Experimental Animal Center adaptability observation one week Use.

1.2 experimental method

1.2.1 prepared by test medicine

Through preliminary experiment by 0.4ml/10g volume give 20 DEG C of lower densities be 1.20g/ml thick paste (recipe quantity crude drug is pressed The extraction concentration of optimal extraction process is about 75ml), find thick paste too it is dense can not gastric infusion, therefore preparation prescription amount crude drug is by optimal Extraction process extraction is condensed into 100ml solution as maximum dosage, i.e. concentration is that 2.04g/ml (presses mouse 0.4ml/10g Maximum volume gastric infusion, concentration 81.6g/kg).

1.2.2 median lethal rate (LD50) determines

Take fasting to can't help water 12 hours, body weight 18-22g mouse 20, male and female half and half, be randomly divided into high dose group (a groups) With low dose group (b groups), every group 10, male and female half and half.Each group is administered once by 0.4ml/10g, and it is 81.6g/ that a groups, which give concentration, Kg compound Jinsha choleretic granules solution, b groups give the compound Jinsha choleretic granules solution that concentration is 40.8g/kg.Connect after administration The toxic reaction of 12 hour record mouse of continuous observation, observation record dead mouse situation in 14 days.

1.2.3 maximum dosage-feeding determines

Take fasting to can't help water 12 hours, body weight 18-22g mouse 40, male and female half and half, be randomly divided into administration group (c groups) and Blank group (d groups), every group 20, male and female half and half.Each group is administered once by 0.4ml/10g, and it is 81.6g/kg's that c groups, which give concentration, Compound Jinsha choleretic granules solution, d groups give distilled water.3 (every minor ticks 6 hours, to feeding after administration are administered in 24 hours Material, after twice be administered before fasting can't help water 3 hours), after administration the toxic reaction of the hour record each group mouse of Continuous Observation 24 and Death condition, Continuous Observation 7 days, record the weight of animals, appetite, outward appearance, behavioral activity and death condition.In experiment last day Mouse is put to death in fasting after can't help water 12 hours, dissection, and whether observation mouse core, liver, spleen, lung, the main organs c groups such as kidney and d groups Change, each group mouse weight changes before and after t examines comparative test.

1.3 experimental result

1.3.1 median lethal rate (LD50) measurement result

Within the observation period, movable reduction is shown after the administration of A groups mouse, look burnout, this phenomenon after half an hour after is administered Fade away；Without any exception after the administration of B groups mouse.The jump behavior without exception of two groups of mouse, non-stimulated sensitive sign, mouth, Eye, nose do not occur abnormal secretion, and diet, drinking-water, defecation are normal, and respiratory activity is normal, have no dead, fail to measure LD₅₀。 It the results are shown in Table 2.

The compound Jinsha choleretic granules team Mouse oral administration LD of table 2₅₀Measure

1.3.2 maximum dosage-feeding determines

Within the observation period, movable reduction is shown after the administration of administration group mouse, look burnout, after administration about after half an hour this Phenomenon fades away.Without dead mouse, behavior, appetite, outward appearance, excretion are without exception, and mouse weight normally increases after being administered 7 days It is long, dissected after execution mouse, visually observe the major organs such as its heart, liver, spleen, lung, kidney and alimentary canal and organize no abnormality seen to show As.It the results are shown in Table 3.

The compound Jinsha choleretic granules of table 3 are to Mouse oral administration maximum dosage-feeding measure

2 compound Jinsha choleretic granules agent anti-inflammatories are tested

A kind of multiple oral administered compound Jinsha choleretic granules agent (original name of Chinese medicine composition of the present invention:Cholagogic decoction) plus taste prescription group Turn into:Desmodium 15.5g, Lygodium japonicum (cloth bag) 15.5g, oriental wormwood 15.5g, root of herbaceous peony 15.5g, Fructus meliae toosendan 15.5g, rhizoma pinellinae praeparata 10.5g, rheum officinale (under rear) 10.5g, root tuber of aromatic turmeric 15.5g, radix bupleuri 10.5g, radix scutellariae 15.5g, Fructus Aurantii 15.5g, Asiatic plantain 30.5g, Pu Public English 3l0.5g.

2.1 experiment material

2.1.1 experimental animal

SPF levels Kunming kind healthy mice 50, male and female half and half, body weight 18-22g, by Hubei Province Animal Experimental Study center There is provided, credit number：SCXK (Hubei Province) 2008-0005, animal quality certification number：42000600002927.Before all zooperies in HuaZhong Science University, TongJi medical school, TongJi Hospital Experimental Animal Center adaptability observation uses for 3 days.

2.1.2 experimental drug and reagent

XIAOYAN LIDAN PIAN (Guangdong Luofushan Sinopharm Co., Ltd., lot number：L13K195)；

Dimethylbenzene is pure to analyze

2.2 experimental method

Fasting is taken to can't help water 12 hours, body weight 18-22 mouse 50 are randomly divided into 5 groups, every group 10, male and female half and half.Fill Stomach is administered, i.e., blank control group is to 40ml/kg distilled water, low dose group administration 8.16g crude drugs/kg, middle dose group administration 16.32g crude drugs/kg, high dose group administration 32.64g crude drugs/kg, positive controls give 0.616g/kg XIAOYAN LIDAN PIANs and go to wrap Clothing.Successive administration 7 days, 1 hour after last time is administered, it is close to the left auricle 15 of mouse with the circular filter paper piece for being impregnated with dimethylbenzene Second cause scorching, put to death mouse after 30 minutes, ear is removed at the same position of mouse or so ear respectively with a diameter of 9mm card punch The weight of piece, precision weighing or so auricle, it is of poor quality as swelling using left and right auricle, with more each group difference of t methods of inspection Conspicuousness, calculate swelling inhibiting rate：Inhibiting rate (%)=[1- (auricle of administration group two is of poor quality/the auricle quality of blank group two Difference)] × 100%.It the results are shown in Table 4.

2.3 experimental result

The influence of the compound Jinsha choleretic granules paraxylene induced mice ear swelling of table 4

Note：Compared with blank control group, * P<0.05；**P<0.01

As a result show, compound Jinsha choleretic granules are high, middle dose group and positive controls have and suppress small caused by dimethylbenzene The effect of mouse ear swelling, significant effect, with the more statistically significant (P of blank control group<0.05 or P<0.01)；Compound Jinsha Although choleretic granules low dose group also plays the role of to suppress dimethylbenzene induced mice ear swelling, relatively do not have with blank control group Statistical significance (P>0.05).

3 compound Jinsha choleretic granules agent cholagogic experiments

3.1 experiment material

3.1.1 experimental animal

SPF levels male SD rat 10, body weight 200-220g, provided by Hubei Province Animal Experimental Study center, licensing Number：SCXK (Hubei Province) 2008-0005, animal quality certification number：42000600003193.In the Central China University of Science and Technology before all zooperies Attached hospital of the Tongji University Experimental Animal Center adaptability observation of Tongji Medical Institute uses for 3 days.

3.1.2 reagent

XIAOYAN LIDAN PIAN (Guangdong Luofushan Sinopharm Co., Ltd., lot number：L13K195)；

Urethane is pure to analyze

3.2 experimental method

Take 200-220g male SD rats 10, be randomly divided into 5 groups, before experiment fasting can't help water 12h, crow is injected intraperitoneally and draws Smooth (1g/kg) is anaesthetized, and dorsal position is fixed, and 3cm opens abdomen under xiphoid-process, and bile duct is found in descendant duodenum mesenterium, separation, Ligature into duodenum end, insertion PE-10 pipes, seeing, which has faint yellow bile to be ligatured after flowing out, is fixed, and bile is collected with EP pipes 30min.Each group collects bile respectively according to dosage respectively by duodenal administration after 30min, 60min, 90min afterwards, totally 4 times, Record the bile flow of each period.It the results are shown in Table 5.

3.3 experimental result

The compound Jinsha choleretic granules of table 5 to bile flow influence (N=2)

As a result show, the basic, normal, high dosage group of compound Jinsha choleretic granules and positive controls are compared with blank control group Compared with, have increase in 30min, 60min, 90min bile flow, show compound Jinsha choleretic granules to bile discharge have promotion make With prompting medicine has choleretic effect to rat.

4. analysis and discussion

Compound Jinsha choleretic granules are pure Chinese medicinal preparation, due to that can not determine median lethal rate, therefore carry out compound Jinsha profit Courage particle solution determines to Mouse oral maximum dosage-feeding.Finally test does not have overt toxicity reaction to experimental animal, Show that the maximum dosage-feeding that mouse is resistant to is 244.8g crude drugs/kg, be 7.5 times of high dose group in mouse pharmacodynamic experiment (anti-inflammatory tests high dose group daily crude drug 32.64g/kg), therefore safety is administered orally in compound Jinsha choleretic granules.

Obstruction or incarceration cystic duct are the common causes for causing acute cholecystitis to courage intracystic stones suddenly, gall-bladder tubotorsion, Narrow and ascarid of biliary tract or biliary tract neoplasm obstruction can also cause acute cholecystitis.And chronic cholecystitis is either in the interpretation of the cause, onset and process of an illness and disease On have close contact, its merge gall stone belong to the categories such as " hypochondriac pain " of the traditional Chinese medical science, " feeling of fullness ".Sick position is in courage, with spleen, liver stomach There is close relationship.Therefore, the two complements each other in the treatment, arranges stone cholagogue and eliminating inflammation collective effect.

Dimethylbenzene can cause some inflammatory mediators, such as histamine, kassinin kinin and fibrinoclase as chemical proinflammatory agent Release.The release of these media can cause the increase of local capillary permeability and the infiltration of inflammatory cell, cause ear anxious The exudative inflammatory edema of property.Therefore acute inflammation model often induces mouse auricular concha swelling to verify medicine with proinflammatory agent dimethylbenzene Antiinflammatory action.

Result of study shows that compound Jinsha choleretic granules paraxylene induces mice ear, and there is certain suppression to make With illustrating to play a part of suppressing inflammation by suppressing dimethylbenzene effect, its mechanism is probably to suppress local capillary The increase of permeability and the infiltration of inflammatory cell, it may be possible to by suppressing histamine, kassinin kinin and the effect of fibrinoclase, It may be by suppressing the release for promoting histamine, kassinin kinin and fibrinoclase of dimethylbenzene, so as to suppress inflammation, alleviate scorching Property swelling.

Bile synthesizes in liver, is secreted to biliary tract, is stored in gall-bladder by cholangiole, and passed through in gall-bladder Concentration.On the feed, especially feed under the stimulation of lipid food, gallbladder contraction, bile excretion to duodenum plays a role.Courage Whether normal the situation of secretion and the excretion of juice is related to liver, gall-bladder and biliary tract function of patients, and the normal transport of bile can promote Enter the discharge of microlith and inflammatory mediator in biliary tract, play a part of usual biliary tract, protection biliary tract.It is various cause choleresis, The disease of acatharsia can destroy biliary tract normal function, cause various disease of biliary tract.The flow velocity of bile is secreted with it in human body Speed and the mechanism correlation in gall-bladder, and rat lacks gall-bladder, can directly react hepatic secretion by the flow velocity of bile The function of bile.

This experimental result shows that compound Jinsha choleretic granules can significantly improve the flow of bile under test dose, Accelerate hepatic secretion bile, prompt compound Jinsha choleretic granules to promote the discharge of bile, play choleretic effect.But due to Sample size is few, can not be from the variable quantity of statistics objective analysis rat bile flow, and this tests the pre- reality as cholagogic experiment Test, the choleretic effect that compound Jinsha choleretic granules are further studied for the later stage provides reference and foundation.

Compound Jinsha choleretic granules (former cholagogic decoction) are Empirical formulas in the institute of Wuhan economic cycle the People's Hospital, to arranging stone Cholagogue and eliminating inflammation has the effect of fine, is the cipher prescription that cholecystitis and cholelithiasis are treated in institute.This experiment is in original formulation On the basis of be improved, to multiple in terms of the experiment of preparation technology, quality control, acute toxicity testing and Pharmacodynamics is several Fang Jinsha choleretic granules are studied.

1. the Main Conclusions of an experiment

Compound Jinsha choleretic granules are by the analysis of pharmacology, drug effect, physicochemical property to each flavour of a drug ingredient, simultaneously With reference to clinical practice, investigated through comprehensive multi-index, designing its preparation technology is：Prescription medicine material is waited to add water to cook in addition to rheum officinale, often Secondary plus 12 times of water (water absorption is supplied in extraction for the first time, adds 16 times of water, is soaked 60 minutes), extract 2 times, decoct 1 hour every time.Greatly It is yellow to be put into when extracting 40 minutes for second.Merge extract solution, filtration, it is 1.20g/ml's to concentrate as (25 DEG C) density under normal temperature Thick paste, 0.5% Aspartame is added, it is 2 to take dextrin and galactose ratio:1, equal increments method is well mixed, and mixed accessories are made. Thick paste presses (1 with auxiliary material:1.5) ratio mix, add 85% ethanol be used as diluent, wet granulation, 80 DEG C dry dryings, it is whole Grain produces.

In order to obtain preparation safely, effectively, stable, Qualitive test and content of this problem to compound Jinsha choleretic granules Measure is studied.Determined in Qualitive test and 3 kinds of Chinese herbaceous peony, radix scutellariae, Fructus Aurantii medicinal materials in prescription differentiated with thin layer chromatography, Gained thin-layer chromatography spot separating degree is good, and clear spot, negative sample is noiseless, shows that this method specificity is good.Assay Using the content of Paeoniflorin in 3 batches of samples of high effective liquid chromatography for measuring, measurement result shows, HPLC detection methods are easy, again Existing property is good, high sensitivity, can be used as one of quality control index, according to measurement result, tentative paeoniflorin content must not be less than 0.8mg/g。

In order to inquire into the drug safety of compound Jinsha choleretic granules oral administration, preparation median lethal rate can not measured In the case of, this problem has carried out measure of the medicine to the maximum dosage-feeding of mouse, finally tests not to experimental animal There is overt toxicity reaction, show that the maximum dosage-feeding that mouse is resistant to is 244.8g (crude drug)/kg, be mouse pharmacodynamic experiment 7.5 times (anti-inflammatory tests high dose group daily crude drug 32.64g/kg) of middle high dose group, therefore compound Jinsha choleretic granules mouth Clothes administration safety.Pharmacodynamics investigation is carried out to compound Jinsha choleretic granules simultaneously, test result indicates that the energy under test dose Obvious auricle edema caused by suppressing mouse dimethylbenzene, and the flow of bile can be significantly improved, that is, accelerate hepatic secretion bile, Its antiinflammation and choleretic effect are prompted.

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6 Chinese medicine composition of the present invention of table and its pharmaceutical formulation composition and Component Source and prescription proportioning are as follows:

Claims (4)

1. a kind of Chinese medicine composition for treating cholecystitis, cholelithiasis, it is characterised in that Chinese medicine composition, which forms, is：Desmodium 10- 30 parts by weight, Lygodium japonicum 10-30 parts by weight, oriental wormwood 10-30 parts by weight, root of herbaceous peony 10-30 parts by weight, Fructus meliae toosendan 10-30 parts by weight, Rhizoma pinellinae praeparata 5-15 parts by weight, rheum officinale 5-15 parts by weight, root tuber of aromatic turmeric 5-15 parts by weight, radix bupleuri 10-30 parts by weight, radix scutellariae 10-30 weight Part, Fructus Aurantii 5-15 parts by weight, Asiatic plantain 20-40 parts by weight, dandelion 20-40 parts by weight.

2. Chinese medicine composition according to claim 1, wherein Chinese medicine composition composition are：The parts by weight of desmodium 15.5, sea The parts by weight of Jinsha 15.5, the parts by weight of oriental wormwood 15.5, the parts by weight of the root of herbaceous peony 15.5, the parts by weight of Fructus meliae toosendan 15.5, the weight of rhizoma pinellinae praeparata 10.5 Part, the parts by weight of rheum officinale 10.5, the parts by weight of root tuber of aromatic turmeric 10.5, the parts by weight of radix bupleuri 10.5, the parts by weight of radix scutellariae 15.5, the weight of Fructus Aurantii 10.5 Part, the parts by weight of Asiatic plantain 30.5, the parts by weight of dandelion 30.5.

3. Chinese medicine composition according to claim 1 or 2, it is characterised in that Chinese medicine composition prepares piece agent, capsule And granule.

4. application of the Chinese medicine composition according to claim 1 or 2 in treatment cholecystitis, cholelith disease drug is prepared.