CN104173921A - Traditional Chinese medicine composition as well as preparation and application thereof - Google Patents

Abstract

The invention belongs to the technical field of medicines, and provides a traditional Chinese medicine composition as well as a preparation and an application thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 10 to 30 parts of lysimachia christinae hance, 10 to 30 parts of lygodium japonicum, 10 to 30 parts of capillary artemisia, 10 to 30 parts of radix paeoniae alba, 10 to 30 parts of szechwan chinaberry fruit, 5 to 15 parts of rhizoma pinellinae praeparata, 5 to 15 parts of rheum officinale, 5 to 15 parts of curcuma aromatica, 10 to 30 parts of Chinese thorowax root, 10 to 30 parts of scutellaria baicalensis, 5 to 15 parts of fructus aurantii, 20 to 40 parts of plantain herb and 20 to 40 parts of dandelion. The traditional Chinese medicine composition is obtained by virtue of creative work on the basis of clinical researches over the years, and has good functions of treating cholecystitis and the like.

Description

A kind of Chinese medicine composition and preparation and purposes

Technical field

The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine composition and preparation thereof with the effect for the treatment of cholecystitis.

Background technology

Showing according to Epidemiological study result, there is biliary system calculus in the crowd in the whole world 5%～15%, wherein has every year 1%～3% patient to cause that because of biliary system calculus the biliary system such as acute cholecystitis or acute cholangitis infects.China biliary system calculus patient accounts for 11.5% of total number of hospitalized same period ^[1].According to the cause of disease of acute cholecystitis and prognosis, cholecystitis is divided into acute cholecystitis and chronic cholecystitis, and acute cholecystitis is Acute Chemical and (or) the bacterial inflammation reaction that gallbladder occurs.Wherein 90%～95% patient is associated with cholelithiasis, is called acute calculosis cholecystitis, 5%～10% acute cholecystitis and the intracapsular bile of gallbladder stasis of blood are long-pending, sepsis and mucosa ischemia relevant be acute acalculous cholecystitis.Acute acalculous cholecystitis is a kind of acute cholecystitis of specific type, and onset is serious conventionally, and prognosis is poorer than acute calculosis cholecystitis, and total case fatality rate is 15% ^[2].Acute cholecystitis case accounts for all stomachache patients' 3%～10%.Acute cholecystitis stomachache old people common (50 years old and above patient).Patient shows acute lasting upper right abdomen stomachache, fever, nausea and vomiting mostly; The result that acute cholecystitis is shown effect is repeatedly exactly chronic cholecystitis.Focus mostly on and change in antiinflammatory, calculus, spasmolytic and living habit about the western medical treatment of cholecystitis and cholelithiasis at present, cannot effect a radical cure, only can relief of symptoms.Chinese medicine is with a long history for the diagnosis and treatment of cholecystitis and cholelithiasis, has wide experience, although lack at present large sample clinical experiment, empirical Chinese traditional treatment definite effect ^[3].

Cholecystitis refers to the active chronic inflammation reaction of gallbladder wall.Cholecystitis is one of modal disease of taking as the leading factor with operative treatment, is also one of modal gastroenteropathy.Cholecystitis had once been considered to a kind of disease in west.Research is reported in the U.S., estimates to have influence on 20～250,000 adults.Whether can be divided into calculus bursa propulsoria inflammation and non-calcareous cholecystitis with cholelithiasis according to cholecystitis.Cholecystitis again can be by the anxious course of disease that relaxes of morbidity through being divided into acute cholecystitis and chronic cholecystitis.And be divided into pure and suppurative cholecystitis according to the order of severity that inflammation involves gallbladder.In cholecystitis patient, approximately have 70%～95% to merge cholelithiasis, all the other can be concurrent in chronic hepatitis, alcoholic liver disease, fatty liver diseases.Calcareous cholecystitis is the most common with women and old people, and its sickness rate increases with the rising at age.

Cholelithiasis is modern medicine name of disease, and Chinese medicine is included in it the categories such as " gallbladder-distention ", " distension related to the liver ", " jaundice ", and Thousand Golden Prescriptions is said: " evil in gallbladder, contrary at stomach, upward overflow of bile giving rise to bitter taste in mouth, the contrary vomiting of gastric qi." liver and gallbladder catharsis malfunction be the basic pathogenesis of cholelithiasis.Cholelithiasis is many due to seven emotions pent-up, eating and drinking without temperance etc. because of due to.The gallbladder being attached to the liver, liver and gall are the exterior and the interior each other, and bile is by the vital essence instituteization life of liver.The Zang-Fu relationships such as pathogenesis and liver and gall taste are close, and one of gallbladder is six internal organs, to lead to as suitable, and the liver failing to maintain the normal flow of QI, bile excretion is not smooth, decocts with the passing of time, becomes sandstone.Huang Baixiong said: " liver being bold and firm viscera, has pent-up, and gas fire is all to be risen, upper criminal's stomach warp, and pain connects two sides of body." " evil in gallbladder, contrary at stomach ", therefore control in principle gallbladder and must control stomach, control stomach and also control gallbladder simultaneously.Treatment by Chinese herbs is taking " dredging ", " clearly ", " leading to ", " profit " as main.

Cholecystitis was apt to occur between 20～50 years old.Women is common compared with male, has the feature of outbreak repeatedly.Often because of intemperance of taking food, being invaded by exogenous pathogen, feelings will is unsuccessful, worm stone blocks, overwork etc., and factor is brought out.Though the traditional Chinese medical science, without the name of disease of acute cholecystitis and chronic cholecystitis, just has relevant discussion as far back as "Nei Jing"." Ling Shu Miraculous Pivot or Divine Axis five pathogenic factors " say ": evil in liver, pain in two sides of body." " Plain Questions Miao stings opinion " say ": evil visitor is in the few sun of foot, network, make us hypochondriac pain being unable to breathe freely." " this Tibetan of Ling Shu Miraculous Pivot or Divine Axis " meaning " gallbladder-distention person, fullness in the hypochondrium and pain is drawn lower abdomen." therefore according to clinical manifestation, acute cholecystitis is attributable to " hypochondriac pain " category, chronic cholecystitis belongs to " gallbladder-distention " category.Lose logical falling with gallbladder, " stagnation of QI and blood may bring about pain " be basic pathogenesis, and its sick at gallbladder internal organs, closely related with the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation, stomach-QI being unable to descend normally.

Motherland's medical science can sporadically appear in related contents such as gallbladder-distention, hypochondriac pain, jaundice to the discussion of this disease.To the understanding of its etiology and pathogenesis, mainly contain following several respects: 1. feelings will is unsuccessful: if hinder because of feelings will, rage impairing the liver, depression is not relaxed, and causes depression of liver-QI, and gallbladder loses logical falling, bile stasis, stagnation of QI and blood may bring about pain, sends out as primary disease.2. intemperance of taking food: have a liking for food delicious food savoury, or it is immoderate to be addicted to drink, impairing the spleen and stomach, causes middle burnt transformation failure of spleen, abnormal ascending-descending of QI, soil is stopped up wooden strongly fragrant, and suffocating of liver and gall is not smooth, and gallbladder internal organs is obstructed, sends out as primary disease.3. being invaded by exogenous pathogen: the damp and hot poison of diseases caused by exogenous pathogenic factor is evil, and damp and hot going from the exterior into the interior, inside accumulates middle Jiao, suffocating of liver and gall dereliction of duty, FU QI being obstructed; Or excessive noxious heat, pent up gallbladder internal organs, make blood lose meat corruption, accumulate and form pus, send out as primary disease; Or diseases caused by exogenous pathogenic factor cold-evil, heresy enters few sun, and cold-evil stagnates, suffocating of liver and gall dereliction of duty, gallbladder internal organs stasis.4. worm stone retardance: on ascarid, disturb, dysfunction of acting as a pivot, logical the falling of gallbladder internal organs is obstructed; Or because of retention of damp-heat in the interior, suffocating of liver and gall dereliction of duty, cholestasis, excretion is obstructed, and decocts into stone, and gallbladder internal organs mechanism of qi is obstructed, and stagnation of QI and blood may bring about pain is sent out as primary disease.5. impairment caused by overstrain is excessive: weakness due to chronic disease, and labor is wanted excessively, to make deficiency of YIN-blood, and gallbladder network loses supports, venation contracture, gallbladder loses logical falling, and not Rong Ze pain, sends out as primary disease.

The traditional Chinese medical science thinks that cholecystitis acute cholecystitis is taking excess syndrome as main, and chronic cholecystitis is common with syndrome of intermingled deficiency and excess.How because of due to the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation, stomach-QI being unable to descend normally.The treatment of cholecystitis is according to the principle of " symptomatic treatment in acute condition, relieving the primary symptom in a chronic case ".Principle for the treatment of is: depressed liver-energy dispersing and function of gallbladder promoting.Acute cholecystitis is commonly used clearing away heat and eliminating dampness, purging FU-organs function of gallbladder promoting method, heat-clearing and toxic substances removing, the treatment of removing heat by catharsis purges intense heat method; Chronic cholecystitis is commonly used depressed liver-energy dispersing and function of gallbladder promoting, the resolving depression method of regulating the flow of vital energy, and clearing away heat-damp and promoting diuresis, function of gallbladder promoting purging FU-organs method are dredged sharp liver and gall, the Wen Han method of activating yang, vital energy regualting and blood circulation-promoting, function of gallbladder promoting analgesia, soothing liver and strengthening spleen, easing the affected liver function of gallbladder promoting method, yin nourishing easing the affected liver, the treatment of heat clearing away profit flesh method.

At present, the sickness rate of cholecystitis rises gradually, and the method for the treatment of cholecystitis is both at home and abroad varied, but because of easily outbreak repeatedly of cholecystitis, various Therapeutic Method are still unsatisfactory, and cholecystitis is still one problem to be solved.

Summary of the invention

The object of the invention is to overcome the existing deficiency of prior art, provide a kind of medicine source abundant, cheap, good to cholecystitis action effect a kind of Chinese medicine composition.The present invention, in conjunction with clinical practice, taking depressed liver-energy dispersing and function of gallbladder promoting as base therapy principle, has invented a kind of complex of antiinflammatory function of gallbladder promoting treatment cholecystitis, obtains more satisfied curative effect.

Prescription Prescription analysis

Cholelithiasis is modern medicine name of disease, and Chinese medicine is included in it the categories such as " gallbladder-distention ", " distension related to the liver ", " jaundice ", and Thousand Golden Prescriptions is said: " evil in gallbladder, contrary at stomach, upward overflow of bile giving rise to bitter taste in mouth, the contrary vomiting of gastric qi." liver and gallbladder catharsis malfunction be the basic pathogenesis of cholelithiasis.Cholelithiasis is many due to seven emotions pent-up, eating and drinking without temperance etc. because of due to.The gallbladder being attached to the liver, liver and gall are the exterior and the interior each other, and bile is by the vital essence instituteization life of liver.The Zang-Fu relationships such as pathogenesis and liver and gall taste are close, and one of gallbladder is six internal organs, to lead to as suitable, and the liver failing to maintain the normal flow of QI, bile excretion is not smooth, decocts with the passing of time, becomes sandstone.Huang Baixiong said: " liver being bold and firm viscera, has pent-up, and gas fire is all to be risen, upper criminal's stomach warp, and pain connects two sides of body." " evil in gallbladder, contrary at stomach ", therefore control in principle gallbladder and must control stomach, control stomach and also control gallbladder simultaneously.Treatment by Chinese herbs is taking " dredging ", " clearly ", " leading to ", " profit " as main.This prescription prescription meets Chinese medical theory.

In this prescription, Herba Lysimachiae is sweet light and flat has a depressed liver-energy dispersing and function of gallbladder promoting, effect of regulating QI to relieve pain, dehumidifying jaundice eliminating, inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling.For eliminating damp-heat, the key medicine of fossil, lithodialysis, calculus, contains flavonoid and phenolic compound in Herba Lysimachiae, and they are by promoting bile secretion and gall bladder emptying to reach the effect of function of gallbladder promoting ^[4,5,6], in preparation, monarch drug money Bi can prevent calculus and cholagogic and lithagogue, can assist the detumescence of Spora Lygodii relieving stranguria by diuresis, calculus; Modern study proves: this product can promote hepatocyte secretion of bile, and in hepatic duct, bile increases, intrinsic pressure increasing, and Oddi's sphincter is lax, impels bile to discharge; Spora Lygodii is sweet cold, and its property declines, can tonneau water channel, again can Qinghua damp and hot, calculus; The Radix Paeoniae Alba is cool in nature, and bitter in the mouth acid, is slightly cold, and returns liver, spleen channel, and function has clearing away heat and cooling blood, suppressing the hyperactive liver pain relieving.Can nourishing blood and promoting blood circulation, depressed liver-energy dispersing and QI regulating, suppressing liver-YANG, clearing away heat and promoting diuresis, the circulation of qi promoting of enriching blood, spleen reinforcing antidiarrheal ^[7], that the Radix Paeoniae Alba has is antipyretic, function of gallbladder promoting, antibacterial effect; Radix Scutellariae bitter in the mouth, cold in nature.Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian, function has heat clearing and damp drying, eliminating fire and detoxication has the effect of anti-inflammation, and two medicine compatibilities have strengthened the dampness removing effect that Huang, Tongli capture that disappears and have been our monarch drug.Radix Curcumae, pungent, bitter, cold, enter conscience lung footpath, promoting flow of QI and blood, joins the soothing the liver circulation of qi promoting of Fructus Toosendan, pain relieving function of gallbladder promoting; Fructus Aurantii regulating the flow of Qi and the middle Jiao, makes QI movement being in harmonious way, and taste lifting is normal, and Radix Et Rhizoma Rhei share and can rush down clearly the bright interior-excess of sun; Herba Artemisiae Scopariae is joined Radix Et Rhizoma Rhei clearing away heat-damp and promoting diuresis, and heresy has place to go.Herba Plantaginis picric acid is cool, enters liver and gall kidney, bladder footpath, and joining Herba Taraxaci has clearing away heat and promoting diuresis, and Tonglin Paishi is more than ministerial drug in prescription; The Rhizoma Pinelliae, pungent, temperature.Poisonous.Return spleen, stomach, lung meridian, effect is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass; And supervise Radix Scutellariae, assistant with Radix Et Rhizoma Rhei, effect that purging heat and dredging bowels, removing blood stasis are enriched blood, the heat clearing away of Radix Bupleuri energy depressed liver-energy dispersing and function of gallbladder promoting, yang invigorating, reconciling superficies and interior, regulating QI to relieve pain, and have priming return through effect; So all medicine compatibilities are long memorial liver and qi altogether, clearing away heat-damp and promoting diuresis, effect of cholagogic and lithagogue.Make liver and gall mechanism of qi happy, the stagnation of QI must except, damp and hot clearly, calculus must change, gallbladder network must be logical, sick must controlling and having no side effect, all medicines share and can promote inflammation to absorb, edema extinction reaches the object of antiinflammatory profit flesh.

Particularly, the invention provides:

A kind of Chinese medicine composition, its Chinese medicine composition comprises: Herba Lysimachiae 10-30 weight portion, Spora Lygodii (cloth bag) 10-30 weight portion, Herba Artemisiae Scopariae 10-30 weight portion, Radix Paeoniae Alba 10-30 weight portion, Fructus Toosendan 10-30 weight portion, Rhizoma Pinelliae Preparatum 5-15 is part heavily, Radix Et Rhizoma Rhei (under rear) 5-15 weight portion, Radix Curcumae 5-15 weight portion, Radix Bupleuri 10-30 weight portion, Radix Scutellariae (under rear) 10-30 weight portion, Fructus Aurantii 5-15 weight portion, Herba Plantaginis 20-40 weight portion, Herba Taraxaci 20-40 weight portion.

Wherein preferred Chinese medicine composition comprises: Herba Lysimachiae 15.5 weight portions, Spora Lygodii (cloth bag) 15.5 weight portions, Herba Artemisiae Scopariae 15.5 weight portions, the Radix Paeoniae Alba 15.5 weight portions, Fructus Toosendan 15.5 weight portions, Rhizoma Pinelliae Preparatum 10.5 weight portions, Radix Et Rhizoma Rhei (under rear) 10.5 weight portions, Radix Curcumae 10.5 weight portions, Radix Bupleuri 10.5 weight portions, Radix Scutellariae (under rear) 15.5 weight portions, Fructus Aurantii 10.5 weight portions, Herba Plantaginis 30.5 weight portions, Herba Taraxaci 30.5 weight portions.

Chinese medicine composition described above is prepared into pharmaceutical preparation.

Pharmaceutical preparation described above comprises decoction, tablet, capsule and granule.

A kind of Chinese medicine composition described above application in preparation treatment cholecystitis medicine.

Decoction preparation method described above is:

Get 11 taste medical materials except Radix Et Rhizoma Rhei, Radix Scutellariae and add 10-15 times of water, soak after 20-40 minute, in extraction pot heating extraction twice,, extract 2-4 time, decoct 0.5-2h at every turn; Radix Et Rhizoma Rhei, Radix Scutellariae, in the time extracting for the 2nd time, and add after immersion treatment under condition more than 70 DEG C that to extract 0.5-2h be optimised process, and merge extractive liquid,, filters, and quiescent setting 10 hours is got the fill heat-sealing while being 1.08g/ml of supernatant concentration to density; Be decocted in water for oral dose 1 dose of every day, each 250ml, takes for 2 times sooner or later.Be finished product decoction of the present invention.

Process for producing granula described above is:

Get 11 taste medical materials except Radix Et Rhizoma Rhei, Radix Scutellariae and add 10-15 times of water, soak after 20-40 minute, heating extraction, extract 2-4 time, decoct 0.5-2 hour at every turn, Radix Scutellariae is in the time extracting for the 2nd time, and more than 70 DEG C, under condition, after immersion treatment, add extract 0.5-2h be optimised process, merge extractive liquid,, filters, and is concentrated into the thick paste that 25 DEG C of density are 1.20g/ml for subsequent use; It is for subsequent use that Radix Et Rhizoma Rhei was pulverized 100 mesh sieves, being mixed and made into dried cream powder with 12 kinds of extractum feeds intake, separately getting dextrin and lactose ratio is 1.5: 1, and equivalent incremental method mix homogeneously, adds 0.5% aspartame, by raw material, adjuvant mix homogeneously, ethanol using 75% is as diluent, and thick paste and the adjuvant ratio of 1: 2.5 is mixed, wet granulation, 80 DEG C of oven dry, granulate and get final product.Be finished particle agent of the present invention.

The preparation method of tablet described above is:

Get except Radix Et Rhizoma Rhei, the outer 11 taste medical materials of Radix Scutellariae add 10-15 times of water, soak after 20-40 minute, heating extraction, extract 2-4 time, each 0.5-2 hour that decocts, Radix Scutellariae is in the time extracting for the 2nd time, and more than 70 DEG C, under condition, after immersion treatment, add extract 0.5-2h be optimised process, merge extractive liquid, filter, be concentrated into the thick paste that 25 DEG C of density are 1.20g/ml, it is for subsequent use that Radix Et Rhizoma Rhei was pulverized 100 mesh sieves, being mixed and made into dried cream powder with 12 kinds of extractum feeds intake, separately getting dextrin and lactose ratio is 1.5: 1, equivalent incremental method mix homogeneously, add 0.5% aspartame, by raw material, adjuvant mix homogeneously, ethanol using 75% is as diluent, thick paste and the adjuvant ratio of 1: 2.5 is mixed, wet granulation, 80 DEG C of oven dry, granulate tabletting, both.Be finished tablet of the present invention.。

The preparation method of capsule described above is:

Get except Radix Et Rhizoma Rhei, the outer 11 taste medical materials of Radix Scutellariae add 10-15 times of water, soak after 20-40 minute, heating extraction, extract 2-4 time, each 0.5-2 hour that decocts, Radix Scutellariae is in the time extracting for the 2nd time, and more than 70 DEG C, under condition, after immersion treatment, add extract 0.5-2h be optimised process, merge extractive liquid, filter, be concentrated into the thick paste that 25 DEG C of density are 1.20g/ml, it is for subsequent use that Radix Et Rhizoma Rhei was pulverized 100 mesh sieves, being mixed and made into dried cream powder with 12 kinds of extractum feeds intake, separately getting dextrin and lactose ratio is 1.5: 1, equivalent incremental method mix homogeneously, add 0.5% aspartame, by raw material, adjuvant mix homogeneously, ethanol using 75% is as diluent, thick paste and the adjuvant ratio of 1: 2.5 is mixed, wet granulation, 80 DEG C of oven dry, granulate adds lubricant, encapsulated, both.Be finished capsule product agent of the present invention.。

Detailed description of the invention

Below the invention will be further described for the description by detailed description of the invention, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various amendments or improvement, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.

One, the clinical observation of antiinflammatory cholagogic Chinese medicine compositions treatment cholelithiasis

The present invention has given prominence to the characteristic of western medicines in treatment, and to cholecystitis special effect, curative effect is fast, short treating period, and stable curative effect does not recur, and within 15th, is 1 course for the treatment of, and take altogether and get final product rehabilitation 2～3 courses for the treatment of, and noinvasive is painless, natural Chinese medicines, easy to use, without any side effects.This prescription is applicable to various types of cholecystitis, through clinical 2645 routine patients' clinical verification, and instant effect, determined curative effect, effective percentage is up to 95.77%, and complication is low, and long-term effect is good, has certain science, advance and practicality.Raw material sources of the present invention are extensive, super quality and competitive price, and cost is low.From curative effect, good results, so this therapy has certain promotion value clinically.

1. clinical data: be selected from outpatient service and inpatient's totally 2645 examples year May in January, 2010 to 2014 with complete data.Be divided at random treatment group 1324 examples, matched group 1321 examples.The treatment group age is 18-70 year, course of disease 1-15, and the matched group age is in 21-67 year, course of disease 1.5-13, age and the course of disease are through X 2 test, without statistical significant difference (ρ > 0.05).

2. diagnostic criteria: Most patients has upper right abdomen or epigastrium distending pain, pain and is radiated to right shoulder back, companion feels sick, inappetence, visible biliary tract " triad " (jaundice, shiver with cold, stomachache) while blocking biliary tract.Confirm to be diagnosed as gallbladder, common bile duct and calculus of intrahepatic duct through B ultrasonic.According to the chronic cholecystitis diagnostic criteria in " new Chinese medicine guideline of clinical investigations (trying) ", with reference to the traditional Chinese medical science dependent diagnostic standard of " Chinese Internal Medicine ", in conjunction with country's " the Seventh Five-Year Plan " brainstorm subject " the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs computer system of Professor Deng Jianhua hypochondriac pain " TCM syndrome diagnostic criteria, be divided into 5 kinds of pattern of syndrome.1. irritability stasis type.Primary symptom: distending pain over the hypochondrium, swollen be far more than pain or taking swollen as main, emotional factors often can bring out or increase the weight of.Inferior disease: dysmenorrhea is indefinite, feeling of fullness and disecomfort in the chest and hypochondrium, distending pain of the breast, menoxenia, sighing frequently, happiness belch, vows that gas turns frequently, distention and pain in the lower abdomen.Tongue arteries and veins: thin white fur of tongue, stringy pulse.2. hepatogastric vital energy stagnation type.Primary symptom: distending pain over the hypochondrium, connects and gastral cavilty.Inferior disease: emotional factors often can bring out or increase the weight of, feeling of fullness and disecomfort in the chest and hypochondrium, lack of appetite is indigestion and loss of appetite, and happiness belch, feels sick, and vomiting is noisy, acid regurgitation, sighing frequently, dysmenorrhea is indefinite, distending pain of the breast, menoxenia.Tongue arteries and veins: thin white fur of tongue, white or micro-greasy, wiry and frequent pulse or stringy and rolling pulse.3. syndrome of liver-stomach heat type.Primary symptom: hypochondriac pain is scorching hot, connects and gastral cavilty.Inferior disease: dry mouth with bitter taste, noisy, acid regurgitation, yellowish urine, constipation, halitosis, aphtha, toothache, flushing conjunctival congestion, nausea and vomiting, lack of appetite is indigestion and loss of appetite, susceptible to lose temper due to restlessness, feeling of fullness and disecomfort in the chest and hypochondrium.Tongue arteries and veins: red tongue, yellow fur, wiry and frequent pulse or stringy and rolling pulse.4. liver gallbladder damp-heat type.Primary symptom: bitter taste mouth is sticky, feeling of fullness and disecomfort in the chest and hypochondrium, the vexed abdominal distention of gastral cavity.Inferior disease: nausea and vomiting, body order cadmium yellow, lack of appetite is indigestion and loss of appetite, and xerostomia is wish drink not, skin pruritus, yellowish urine, constipation.Tongue arteries and veins: red tongue, yellow and greasy fur, stringy and rolling pulse.5. deficiecny of liver-YIN type.Primary symptom: side of body rib dull pain, prolong silk floss endlessly, meet labor and increase the weight of.Inferior disease: feverish sensation in the palms and soles, hectic fever night sweat, xerostomia, dizzy, the poor dreaminess of sleeping.Tongue arteries and veins: red tongue, few tongue, stringy,thready and rapid pulse.

3. inclusive criteria: in meeting, the diagnostic criteria of doctor trained in Western medicine chronic cholecystitis.18～70 years old age, male or female.

Clinical treatment

The treatment of Therapeutic Principle's cholecystitis is according to the principle of " symptomatic treatment in acute condition, relieving the primary symptom in a chronic case ".Therapeutic Method is: depressed liver-energy dispersing and function of gallbladder promoting.Acute cholecystitis is commonly used clearing away heat and eliminating dampness, purging FU-organs function of gallbladder promoting method, heat-clearing and toxic substances removing, the treatment of removing heat by catharsis purges intense heat method; Chronic cholecystitis is commonly used depressed liver-energy dispersing and function of gallbladder promoting, the resolving depression method of regulating the flow of vital energy, and clearing away heat-damp and promoting diuresis, function of gallbladder promoting purging FU-organs method are dredged sharp liver and gall, the Wen Han method of activating yang, vital energy regualting and blood circulation-promoting, function of gallbladder promoting analgesia, soothing liver and strengthening spleen, easing the affected liver function of gallbladder promoting method, yin nourishing easing the affected liver, the treatment of clearing heat secreting bile method.Chinese traditional treatment target: 1. control symptom, diminish inflammation; 2. shorten the course of disease, reduce recurrence; 3. reduce complication rate.

4. Therapeutic Method: matched group: adopt conventional oral XIAOYAN LIDAN PIAN, every day 3 times, continuous 30～90 days.Treatment group: the choleretic granules agent of compound recipe gold sand and function of gallbladder promoting decoct clinical experience side medicine composition: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Under rib, pain adds 15 grams of Radix Bupleuri, 10 grams of the Radix Paeoniae Albas; Constipation person adds 5 grams of Radix Et Rhizoma Rhei (taking after mixing it with water); The large person of calculus granule (0.6cm, < 0.5cm) takes Chinese medicine expectant treatment to add each 10 grams of 20 grams of Herba Plantaginiss, Radix Curcumae, Spora Lygodii; Vomiter adds 10 grams of Rhizoma Pinelliae Preparatum.The dialectical typing opinion of controlling 1. acute cholecystitiss is controlled the hot and suffocating card method for the treatment of of (1) gallbladder internal organs: clearing away heat-damp and promoting diuresis, circulation of qi promoting function of gallbladder promoting.With reference to treatise on Febrile Diseases) add herbal medicine: Radix Bupleuri, Radix Scutellariae, Radix Et Rhizoma Rhei (under rear), Fructus Aurantii, Rhizoma Pinelliae Preparatum, Herba Artemisiae Scopariae, Herba Plantaginis.(2) excessive noxious heat card method for the treatment of: heat-clearing and toxic substances removing, removing heat by catharsis purges intense heat person adds and subtracts medicine: Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae, Herba Taraxaci, Herba Plantaginis.The typing opinion of 2 chronic cholecystitiss is controlled (1) QI stagnation of the liver and galibladder card: method for the treatment of: depressed liver-energy dispersing and function of gallbladder promoting, the resolving depression of regulating the flow of vital energy.Add and subtract medicine with reference to Jing-Yue Complete Works: Radix Bupleuri, Fructus Aurantii, the Radix Paeoniae Alba, Radix Scutellariae, Herba Plantaginis, Radix Curcumae.(2) syndrome of dampness-heat of liver and gallbladder: method for the treatment of: clearing away heat-damp and promoting diuresis, function of gallbladder promoting purging FU-organs.Add and subtract medicine with reference to " collection of prescriptions with notes ": Radix Scutellariae, Radix Bupleuri, Herba Plantaginis, Radix Et Rhizoma Rhei (under rear).Be decocted in water for oral dose, every day 2 times, each 150ml, 15 days was 1 course for the treatment of.Treatment cholelithiasis effect is fine;

5. efficacy assessment standard: this efficacy assessment standard is to formulate with reference to " new Chinese medicine guideline of clinical investigations ", specific standards is as follows: 1. recovery from illness: clinical symptoms sign disappears, and liver function is normal, and courage type-B ultrasonic inspection is normal, the emptying of B ultrasonic check calculus, nothing recurrence in 1 year; 2. effective: clinical symptoms sign disappears, and liver function is normal, and courage type-B ultrasonic inspection is normal, discharges calculus in stool, B ultrasonic check calculus significantly reduces, nothing recurrence in half a year; 3. effective: clinical symptoms sign disappears, and total bilirubin increases, courage type-B ultrasonic inspection prompting gallbladder intracystic stones exists, nothing recurrence in March; Invalid: clinical symptoms sign and auxiliary examination are showed no improvement.

6. therapeutic outcome: two groups of therapeutic outcomes are as shown in table 1:

Table 1 liang group cure rate synopsis

Group	Number of cases	Cure number	Cure rate
				Treatment group	1324	1268	95.77％
Matched group	1321	1078	81.60％

Through X 2 test, two groups of effective percentage comparisons, difference has very significant (P < 0.001).In a word, it is to various calculus determined curative effects, and energy fossil, calculus, fundamentally cure lithiasis patient, especially in being suitable for, old age and weak patients, utilize this traditional Chinese medicine composition for treating patient 1324 examples, result is cured 1292 examples, effective 56 examples, total effective rate is up to 100%, cure rate 95.77%.Far above the total effective rate of matched group 81.60%, and have no side effect.

Model case:

1, side so-and-so, female 49 years old, Chuan Baixiu street before the Huang Po of Xian Zhu Hubei Province, previously with " postcholecystectomy 3 years, right hypochondrial region 3 days " 1, main suit, is admitted to hospital on July 21st, 2010.Patient before 3 years because gallbladder and choledocholithiasis are at me institute's row gallbladder removal and Choledocholithotomy, operation smoothly, post-operative recovery is good, before 3 days, (on July 18th, 2010) right Upper abdominal pain happens suddenly, take on back radiation to the right, and the heat that occurs together, detest greasy food, nauseating tending to vomit, abdominal distention poor appetite constipation dark coloured urine.Have a medical check-up: mind is clear, spirit is poor, T:38.8 DEG C, P:82 beat/min, R:20 beat/min, BP:130/90mmHg sanity, upper right abdomen has a stringer operative incision cicatrix that is about 6cm, and without visible peristalsis visible intestinal peristalsis, upper right abdomen has tenderness without rebound tenderness, Fei Shi does not levy feminine gender, borborygmus is normal, routine blood test: WBC15.7X 109L, HGB135g/L, PLT:246X 109L, NEUT%0.739; B ultrasonic shows: choledochectasia, and diameter 1.3cm, the common bile duct exit strong echo of visible about 1.1X0.9 group, Echo heterogenicity, rear accompanying sound shadow, probe promotes can be movable.Diagnosis: 1. choledocholithiasis companion cholangitis; 2. after Cholecystectomy And Common Bile Duct Exploration.Oral administered compound gold sand choleretic granules agent (function of gallbladder promoting decoct) adds taste: prescription consists of: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Be decocted in water for oral dose 1 dose of every day, each 250ml, sooner or later 2 clothes.Give quiet of ampicillin, gentamycin, vitamin K1 3 days simultaneously.Only remission of pain afterwards in 2 days, takes medicine 10 doses, and B ultrasonic shows: hepatic duct is slightly expanded, and the about 1.1cm of Common Bile Duct Diameter, without finding abnormal echo, renews 5 doses to consolidate curative effect.After more than 3 years, follow up a case by regular visits to so far without recurrence.

2, old XX, female, 46 years old, department: outer two sections, entered to examine in 2010-08-24 day.AD: cholelithiasis; Cholecystitis; Choledocholithiasis; Right Knee Trauma is postoperative.The diagnosis and treatment of being admitted to hospital process: patient, because of upper right abdomen discontinuity pain more than 8 years, increases the weight of to be admitted to hospital for two days, PE:T:37.6 DEG C, P:80 beat/min, R:20 beat/min, BP:120/80mmHg sanity, skin, sclera is without xanthochromia, and cardiopulmonary check without special.Abdomen is flat soft, under xiphoid-process and the upper right dark tenderness of abdomen (+), rebound tenderness (-).Hepatic region is without kowtowing pain, and liver dullness circle exists.Borborygmus is normal.Abdominal part color ultrasound examination prompting cholelithiasis; Gallbladder enlargement; Common bile duct broadening; Lower common bile duct calculus, liver function test: glutamate pyruvate transaminase (ALT), 127 ↑ U/L; Glutamic oxaloacetic transaminase, GOT (AST), 64 ↑ U/L; γ glutamyl transpeptidase (GGT), 96 ↑ U/L, T-CHOL (CHOL), 3.38 ↓ mmol/L, ApoA (APOA), 0.98 ↓ g/L.Color ultrasound prompting: gallbladder size 58 × 22mm, cyst wall thickens, and about 6mm is double contour sign sample and changes, and sees a diameter 0.5mm high light group, rear accompanying sound shadow in it.Internal diameter of common bile duct 4mm, has no agglomerate echo in it, in liver, slightly strong echo is considered hemangioma; Gallbladder wall edema, cholelithiasis; Spleen, pancreas and two kidney no abnormality seen.After being admitted to hospital, oral compound Jin sand choleretic granules agent (original name: function of gallbladder promoting decoct) adds taste: prescription consists of: oral administered compound gold sand choleretic granules agent (function of gallbladder promoting decoct) adds taste prescription and consists of: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Be decocted in water for oral dose 1 dose of every day, each 250ml, sooner or later 2 clothes.Given antiinflammatory, hepatoprotective and improved coherence check simultaneously, since taking compound recipe gold sand choleretic granules of the present invention agent (original name: function of gallbladder promoting decoct), after 1 week, patient's clinical symptoms is obviously alleviated, 3 all after date transference cures, continue to take and consolidate curative effect 1 course for the treatment of.After 3 years, follow up a case by regular visits to so far without recurrence.

3, Shen XX, female, 18 years old, department: outer two sections, entered to examine on October 25th, 2010.AD: choledochal cyst, cholecystitis.The diagnosis and treatment of being admitted to hospital process: patient is admitted to hospital because of upper right abdomen discontinuity pain for more than 4 years, PE:T:37 DEG C, P:80 beat/min, R:20 beat/min, BP:120/80mmHg (kpa) haves a medical check-up: sanity, cardiopulmonary check without special.Abdominal muscle is soft, under xiphoid-process and the upper right dark tenderness of abdomen (+), rebound tenderness (-).Hepatic region is without kowtowing pain, and liver dullness circle exists.Borborygmus is normal.Liver function test: γ glutamyl transpeptidase (GGT), 130 ↑ U/L; Uric acid (URCA), 129.10 ↓ umol/L; T-CHOL (CHOL), 2.72 ↓ mmol/L; High density lipoprotein (HDL), 0.79 ↓ mmol/L; Low density lipoprotein, LDL gallbladder (LDL), 1.6 ↓ mmol/L.Color ultrasound prompting: gallbladder size and form is normal, and gallbladder wall is slightly thick, is shown in few hot spot accumulation of being permitted in capsule.Common bile duct goes out the internal diameter 17MM of hepatic portal place, stage casing internal diameter 43MM, and hypomere narrows gradually, and internal diameter 8MM is shown in few hot spot of being permitted, the expansion of common bile duct cryptomere in common bile duct; In gallbladder and common bile duct, finding is considered minute quantity silt calculus or gallbladder mud; Liver, spleen, body of pancreas and two kidney show no obvious abnormalities.After improving coherence check after being admitted to hospital, give antiinflammatory symptomatic treatment, patient clinical symptom is obviously alleviated.Oral administered compound gold sand choleretic granules agent (function of gallbladder promoting decoct): prescription consists of: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Be decocted in water for oral dose 1 dose of every day, each 250ml, sooner or later 2 clothes.Give to giving antiinflammatory, hepatoprotective and improving coherence check, since taking function of gallbladder promoting decoct of the present invention, after 1 week, symptom is alleviated simultaneously, and 3 all after date transference cures continue to take and consolidate curative effect 1 course for the treatment of.After 3 years, follow up a case by regular visits to so far without recurrence.

4. Lee XX, female, 63 years old, department: outer three sections, enter to examine in December in 2011 on the 13rd.AD: cholelithiasis; Chronic cholecystitis.The diagnosis and treatment of being admitted to hospital process: patient was admitted to hospital because of " being interrupted upper right abdominal distention and pain more than 10 years ".Previously body constitution still can, without operation trauma history and susceptibility history.Have a medical check-up: god is clear, spirit can, check cooperation, look natural, active posture, sclera is not yellow, cardiopulmonary are not and obviously abnormal.Abdomen is flat soft, without tenderness, rebound tenderness, under liver spleen rib not and, Shuan Shen district is without kowtowing pain, borborygmus is normal.Extremity activity can.Outpatient service data: I show schistosomicide liver, cholelithiasis by Out-patient Department B ultrasonic.After patient is admitted to hospital, improves and check, in symptomatic treatment on the 14th, conditions of patients was stable, and recovery can.Color ultrasound prompting: gallbladder size and form is normal, is shown in several high light group in capsule, one of them diameter is 0.7cm, and rear accompanying sound shadow is removable with Body Position Change.Common bile duct epimere internal diameter is 0.5cm.Spleen Size form is normal, and essence luminous point is evenly distributed, no abnormality seen agglomerate echo in it.Oral administered compound gold sand choleretic granules agent (original name: function of gallbladder promoting decoct) adds taste prescription and consists of: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, Fructus Toosendan gives 15.5 grams, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Be decocted in water for oral dose 1 dose of every day, each 250ml, sooner or later 2 clothes.Give, to giving antiinflammatory, hepatoprotective and improving coherence check, to take 10 doses of function of gallbladder promoting decocts of the present invention, after 1 week, symptom is alleviated simultaneously, 2 all after date transference cures, continue to take 1 the course for the treatment of 10 doses of function of gallbladder promoting decocts to consolidate curative effect.After 2 years, follow up a case by regular visits to so far without recurrence.

5. Bears XX, man, 63 years old, serious symptom medical science section, entered to examine on April 22nd, 2012.AD: cholelithiasis; Cholecystitis, pulmonary tuberculosis? the diagnosis and treatment of being admitted to hospital process: patient is admitted to hospital because of " cough, the short gas of expectoration occurs together hot 20 days ", does not previously tell special medical history.Have a medical check-up: T38 DEG C of P100 beat/min, R22 beat/min, BP150/80mmhg sanity, breathe slightly rapid, handsome, dicoria Deng great Deng garden, diameter 3mm, to luminous reflectance sensitivity.Be admitted to hospital and improve coherence check, give infection, relieving asthma, eliminate the phlegm, symptomatic treatment.Liver function test: total protein 59.8 ↓ g/L; Albumin 22.6 ↓ g/L; Total bilirubin 72.6 ↑ umol/L; Bilirubin direct 62.5 ↑ umol/L; Glutamate pyruvate transaminase 63 ↑ U/L; Glutamic oxaloacetic transaminase, GOT 92 ↑ U/L; Alkali phosphatase 334 ↑ U/L; γ glutamyl transpeptidase 531 ↑ U/L; TOTAL BILE ACID TBA 63.4 ↑ umol/L; Acetylcholine esterase 1357 ↓ U/L.Color ultrasound prompting: liver section form size is still normal, essence luminous point increases thick, skewness, stones in intrahepatic bile duct has no obvious expansion, and liver blood pipeline distribution is still clear, sees that a size is about the low echo of 10.8 × 7.5cm group in liver, and it is clear that owe on border.Gallbladder size 6.6 × 2.2cm, is shown in several high light group in capsule, one of them diameter is 0.5cm, rear accompanying sound shadow.Spleen Size form is normal, and essence luminous point is evenly distributed, no abnormality seen agglomerate echo in it.Essence occupying lesion in liver; Cholelithiasis; Seroperitoneum.Given antiinflammatory, hepatoprotective and improved coherence check, add taste prescription and consist of since taking oral administered compound gold sand choleretic granules of the present invention agent (function of gallbladder promoting decoct): 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Be decocted in water for oral dose 1 dose of every day, each 250ml, sooner or later 2 clothes.Give to giving antiinflammatory, hepatoprotective and improving coherence check, after 1 week, symptom is alleviated simultaneously, and 3 all after date transference cures continue to take and consolidate curative effect 1 course for the treatment of.After 2 years, follow up a case by regular visits to so far without recurrence.

6. Pei XX, female, 43 years old, address: before yellow pond Chuan Baijin street, suffered from cholecystitis, cholelithiasis more than 5 years, is diagnosed as cholecystitis, cholelithiasis, takes medicine throughout the year, has no improvement.Noon on March 16th, 2011, patient was because " upper abdomen has an intense pain, and the high heat companion that shivers with cold vomits, and yellow sclera is expressed one's feelings painful, medical.Patient's private prosecution, once in morning February 19 in 2011 unexpected upper abdomen have an intense pain, pain is takeed on radiation to the right, the high heat companion's vomiting of shiver with cold, yellow sclera, expression is painful, constipation, yellow and greasy fur, stringy pulse.Take the photograph sheet, ultrasound diagnosis through Wuhan City's one six one hospital's x-ray radiographies and be all diagnosed as cholelithiasis, all 0.6cmX13cm.Liver function test: icteric index 27 units.Glutamate pyruvate transaminase 106 units.Examine card ginseng arteries and veins, this is that dampness-heat in the liver and gallbladder is pented up, and bile is obstructed, and gradually becomes cholelithiasis.Control with depressed liver-energy dispersing and function of gallbladder promoting eliminating heat pathogen by purging the bowels calculus.Oral clinical experience side's compound recipe gold sand choleretic granules agent (original name: function of gallbladder promoting decoct), prescription consists of: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Add and subtract with disease: hypochondriac pain severe one, adds 10 grams of effects with enhancing regulating QI to relieve pain of Fructus Toosendan; Stomach-QI being unable to descend normally, disease sees nausea and vomiting person, our de-etiolation a kind of reed mentioned in ancient books adds Rhizoma Pinelliae Preparatum with stomach function regulating preventing or arresting vomiting.1 dose of every day, decocting 2 times, extracting juice 250ml altogether, point morning and evening 2 clothes, 1 month were 1 course for the treatment of.Serve on 10 pairs, cold and heat are gradually separated, and pain relief is defecated unimpeded, and icteric index reduces.Enter 10 pairs, vomiting stops again, and cold and heat move back, and jaundice is subdued, and tongue fur moves back, and two is just normal.10 pairs of clothes tops, discharge 5 of the large microliths of Semen phaseoli radiati continuously.Again take 15 pairs, through function section, B ultrasonic check prompting is normal, have no cholelithiasis light group, arteries and veins eases up, and all diseases are cured, and adds taste since taking clinical experience side's compound recipe gold sand choleretic granules agent of the present invention (original name: function of gallbladder promoting decoct), give to giving antiinflammatory, hepatoprotective and improving coherence check simultaneously, after taking 1 week of the present invention, symptom is alleviated, and 2 all after date transference cures continue to take and consolidate curative effect 1 course for the treatment of.After 3 years, follow up a case by regular visits to so far without recurrence.

7, Hu XX, female, 58 years old, department: outer three sections, medical on November 18th, 2011.The situation of being admitted to hospital and diagnosis and treatment process: because being interrupted, right Upper abdominal pain is uncomfortable is admitted to hospital patient for approximately 5 days, haves a medical check-up: T:36.3 DEG C, P:80 beat/min, R:19 beat/min, BP:110/70mmHg (kpa) god is clear, looks natural, active posture, the cooperation of having a medical check-up, sclera is not yellow, and abdomen is flat soft, without tenderness, rebound tenderness, under liver spleen rib not and, Shuan Shen district without kowtow pain, borborygmus is normal.After being admitted to hospital, looking into color ultrasound shows: cholelithiasis; Atrophy of gallbladder, is given antiinflammatory, hepatoprotective and is improved coherence check symptomatic treatment.Liver function test: glutamate pyruvate transaminase, 85U/L.Color ultrasound prompting: intraperitoneal is shown in the strong reecho of a large amount of gas, liver partial image shows unclear, remaining liver form normal in size, essence luminous point increases thick, distribution is owed evenly, is ground-glass-like and changes, and in liver, tube structure is out of shape normal, vasoganglion clear display, is shown in liver that a diameter is the high light group of 0.3cm.Gallbladder is about 3.9 × 1.2cm, sees multiple high light group in capsule, and one of them diameter is 0.6cm.Gallbladder wall is slightly thick.Common bile duct epimere internal diameter is 0.5cm.Oral administered compound gold sand choleretic granules agent (original name: function of gallbladder promoting decoct) prescription consists of: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Be decocted in water for oral dose 1 dose of every day, each 250ml, sooner or later 2 clothes.Give to giving antiinflammatory, hepatoprotective and improving coherence check, since taking function of gallbladder promoting decoct of the present invention, after 1 week, symptom is alleviated simultaneously, and 2 all after date transference cures continue to take and consolidate curative effect 1 course for the treatment of.After 2 years, follow up a case by regular visits to so far without recurrence.

8. old XX, female, 59 years old, department: outer three sections, suffer from cholelithiasis more than 12 years, within 8th, go to a doctor in December in 2011.AD: suffer from abdominal pain to be checked: cholelithiasis? pancreatitis? after right nephrostomy.The diagnosis and treatment of being admitted to hospital process: patient has typical clinical symptoms and sign, because " hematuria January more than, companion's right hypochondrial region shoulder release to the right 3 days " is admitted to hospital.Face of acute ill, breathe steadily, abdominal tympanites, soft-fat type, abdomen is soft, upper abdomen tenderness, there is light percussion pain in You Shen district, and right lumbar region has a stoma, inside has the courageous and upright urine of peony, has a little blood clot.Borborygmus is normal.Previously be diagnosed as: bronchitis medical history more than 20 years, there is hypertension history 10 years, there are gallbladder stone disease history 10 years, take medicine throughout the year, have no improvement.There are renal insufficiency, cholelithiasis medical history.Blood examination prompting hepatic and kidney function obstacle.Abdominal part color ultrasound B ultrasonic report prompting cholelithiasis: be right stones in intrahepatic bile duct 0.4～0.6cm calculus, atrophy of gallbladder.After being admitted to hospital, being given antiinflammatory, hepatoprotective and improved coherence check symptomatic treatment.Liver function test: glutamate pyruvate transaminase (ALT), 118 ↑ U/L; Glutamic oxaloacetic transaminase, GOT (AST), 504 ↑ U/L; Alkali phosphatase (ALP), 174 ↑ U/L; γ glutamyl transpeptidase (GGT), 248 ↑ U/L; Blood urea nitrogen (BUN) ↑ 8.8mmol/L; Creatinine (CREA), 227 ↑ umol/L; Sodium (NA), 145.2 ↑ mmol/L; Chlorine (CL), 116.2 ↑ mmol/L.Color ultrasound prompting: gallbladder size is 6.3 × 2.9cm, is shown in several high light group in capsule, rear accompanying sound shadow, and one of them major diameter is 2.4cm, common bile duct epimere internal diameter is 1.4cm.Lower common bile duct shows unclear.Consist of since taking compound recipe gold sand choleretic granules of the present invention agent (function of gallbladder promoting decoct) prescription: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Be decocted in water for oral dose 1 dose of every day, each 250ml, sooner or later 2 clothes.Give to giving antiinflammatory, hepatoprotective and improving coherence check, after 30 days, symptom is alleviated simultaneously, and transference cure after 2 months continues to take and consolidates curative effect 2 courses for the treatment of.2 years afterwards regularly further consultation accuse recovery from illness without recurrence.

9, medical record is wished certain for example, female, 38 years old.Department: an outer section, community, Pan Jia field, Huangpo District, Xian Zhu Wuhan City, long for the court's Nurses of Emergency Department, on February 24th, 2012, patient was admitted to hospital because of " being interrupted pain over the chest and back companion's vomiting in 1 year 1 day ".2. history of present illness: patient told before 1 year and occurs the pain over the chest and back without obvious inducement is paroxysmal pain.Companion's vomiting, vomitus is gastric content and food debris.Without acid regurgitation, belch.Without stomachache, diarrhoea.Without heating, cough, expectoration.Nothing is nervous, uncomfortable in chest, chest pain is uncomfortable.History of past illness: have pain companion abdominal distention while feeling right upper quadrant of the abdomen before half a year, and be radiated to shoulder, more violent when pain outbreak, injection dolantin still can not stop, and accompanies the soreness of waist.Be diagnosed as chronic cholecystitis, gallbladder intracystic stones through the Color B-Type Ultrasonic inspection of function section.Today, right Upper abdominal pain showed effect again, and patient refuses operation, turns the treatment that takes traditional Chinese medicine.Card belongs to damp-heat accumulation, and liver and gall are lost in catharsis, are polymerized to calculus.Control plan depressed liver-energy dispersing and QI regulating, clearing away heat and eliminating dampness function of gallbladder promoting.Starting to take this patent clinical experience side compound recipe gold sand choleretic granules agent (function of gallbladder promoting decoct) prescription consists of: 15 grams of Herba Lysimachiaes, 30 grams of Herba Plantaginiss, 20.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes, 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Be decocted in water for oral dose 1 dose of every day, each 150ml, sooner or later 2 clothes.Give, to giving antiinflammatory, hepatoprotective and improving coherence check, to take after 10 pairs, right Upper abdominal pain removes simultaneously, and stool day row 4 times is half congealed rotten, finds that 3 pieces greatly as the thunder egg of Semen Glycines in stool.Former side removes Radix Et Rhizoma Rhei, continues and takes 5 pairs, and all diseases are all removed, and enter again 15 pairs, as a means of consolidation.The recurrence of following up a case by regular visits to that so far there are no in 2 years.

10, open XX, man, 68 years old, department: an outer section, suffer from cholelithiasis more than 15 years, be diagnosed as cholelithiasis, take medicine throughout the year, have no improvement.Case feature: 1. patient main suit: on December 27th, 2012, because " right Upper abdominal pain more than 7 hours " again recurs and be admitted to hospital, now live three Li Qiaoyandi villages, yellow pond; 2. history of present illness: patient's this morning occurred right Upper abdominal pain on a full stomach about at approximately 3 o'clock in afternoon, companion's vomiting and heating, the uncomfortable in chest and diarrhoea without hematemesis.After morbidity, once checked at Wuhan 161 hospital admission line correlations, not row treatment, its stomachache is without alleviating.Patient is existing to our hospital, and outpatient service is taken in my section's treatment with " acute cholecystitis, cholelithiasis, choledocholithiasis ".3. history of past illness: previously have cholelithiasis, emphysema, the medical histories such as hepatic insufficiency, deny drug allergy history.4. physical examination: 40 DEG C of the body temperature of being admitted to hospital, 98 beats/min, pulse (irregular), breathes 20 beats/min (rule) blood pressure 110/70mmHg.Line correlation inspection after being admitted to hospital, MRI shows: common bile duct stage casing calculus, gallbladder Calculus, cholecystitis (fossa for gallbladder edema) rabat shows: chronic bronchitis, and emphysema, pulmonary function shows: severe is limited in respiratory disorder, row infection, symptomatic treatment, informs family members' risk, and family members require expectant treatment.AD: acute cholecystitis, choledocholithiasis, cholelithiasis, acute cholangitis, emphysema, hepatic insufficiency.5. auxiliary examination: pulmonary function shows: severe obstruction of pulmonary ventilation, rabat shows: chronic bronchitis inflammation, emphysema, aortic knob calcification, biliary tract MRI shows: common bile duct stage casing calculus, gallbladder Calculus, cholecystitis, pulmonary dysfunction at present, modern please the Respiratory Medicine consultation of doctors treatment, treatment is the same.Taking this patent clinical experience side compound recipe gold sand choleretic granules agent (original name: function of gallbladder promoting decoct) prescription consists of: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Be decocted in water for oral dose 1 dose of every day, each 250ml, sooner or later 2 clothes.Giving to giving antiinflammatory, hepatoprotective and improving coherence check simultaneously. color ultrasound shows: liver form is normal, shows no obvious abnormalities signal change in liver parenchyma; Stones in intrahepatic bile duct has no obvious expansion; Common bile duct is expansion slightly, approximately 1.2 × 1.3cm nodositas T2WI low signal of the visible size in common bile duct stage casing; Gallbladder increases, and cyst wall thickens.Common bile duct stage casing calculus; Gallbladder Calculus, cholecystitis (fossa for gallbladder edema).Medication: 27,/12 0.9% sodium chloride pin 250ml, Cefodizime pin skin test, 8/1 compound recipe Spora Lygodii choleretic granules (original name: function of gallbladder promoting decoct) × 15 pairs, 27,/12 0.9% sodium chloride pin 100ml, Cefodizime pin 2.0g, 0.5% first nitre holder pin 200ml, 0.9% sodium chloride pin 100ml, pantoprazole pin 60mg, 0.9% sodium chloride pin 250ml, diammonium glycyrrhizinate pin 150mg, 0.9% sodium chloride pin 100ml, dimension K20mg.Discharge instructions: bland liquid diet, uncomfortable with examining, since take function of gallbladder promoting decoct of the present invention after 15 days symptom alleviated, transference cure after 3 courses for the treatment of, continues to take and consolidates curative effect 3 courses for the treatment of.The recurrence of following up a case by regular visits to afterwards more than a year that so far there are no.

11, stone so-and-so, women, 69 years old, department: an outer section, accounting, health is better.Address: Qian Chuan Jie Shuan Qing Yuan community, Huangpo District, noon on April 26th, 2011 patient " because right side side of body flank pain is radiated to shoulder back, distension and fullness in the abdomen, then send out 1 day " be admitted to hospital.。History of past illness: cholelithiasis cholecystitis 7 years, take compound recipe Fel Ursi acid sheet throughout the year, have no improvement.Within 1 week, come, because of recurrence again after fatigue, food greasy food, to increase the weight of hurt like hell by disease.Sulky rear above-mentioned symptom increases the weight of significantly, and hurt like hell after recurrence, accompanies vexedly, and emotion is not very good, recurs every year 2 times.Have a medical check-up: under right rib, can lay one's hand on and the gallbladder of enlargement, tenderness under the right rib of limitation, without rebound tenderness, side of body flank position, right side percussion pain.Red tongue, yellow fur is slightly greasy, stringy pulse and tight.Color ultrasound ultrasound diagnosis is shown: gallbladder is enlargement slightly, major diameter 8.5cm, and transverse diameter 5cm, is multiple cholelithiasis 0.3～0.5cm, gallbladder wall thickness, crude.Liver function: glutamate pyruvate transaminase 58umol/L, total bilirubin 26umol/L, bilirubin direct 19umol/L, unconjugated bilirubin 9umol/L.Routine blood test: leukocyte 11.3X109/L, neutrality 75.6%, once with cholelithiasis cholecystitis treatment.With 6 grams of intravenous drips of sodium ampicillin, every day 2 times, Anisodamine 10mg, every day 2 times, the symptomatic treatments such as intramuscular injection can only alleviating pain, unstable condition.The traditional Chinese medical science is thought: side of body rib is position, liver and gall place, and the disease of side of body rib, belongs to liver and gall two warps, and this onset of disease mostly is the stagnation of QI, is persistence distending pain, paroxysmal aggravation sometimes.The stagnation of QI is obstructed, consolidates to alter and has a pain, therefore pull and the right side shoulder back of the body.Irritability stasis, affects taste, dysfunction of the spleen in transportation, and, there is distension and fullness in the abdomen in the stomach failing to send downwards, feels sick, poor appetite is weak.Pathogenic fire derived from stagnation of liver-QI, bitter taste, yellowish or reddish urine, the symptoms such as low grade fever, with the passing of time the stagnation of QI, causes blood stasis, occurs that right side side of body flank pain pulls and take on back.Sign: right flank flank has slight percussion pain, can lay one's hand on and the gallbladder of enlargement, and tenderness limitation is fixing.Method for the treatment of: depressed liver-energy dispersing and QI regulating, blood stasis dispelling calculus, removing obstruction in the collateral to relieve pain.Add taste prescription and consist of since taking clinical experience side's compound recipe gold sand choleretic granules agent of the present invention (original name: function of gallbladder promoting decoct): 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 20.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Take 1 dose of every day each 250ml, sooner or later 2 clothes.Serve on 10 pairs.Give to giving antiinflammatory, hepatoprotective and improving coherence check, patient right side side of body flank pain is radiated to shoulder back simultaneously, abdominal distention, and belch, poor appetite is weak, bitter taste, the symptoms such as yellowish or reddish urine subtract greatly, and appetite increases.Not method more of effect, then keep 15 pairs of former sides, right side side of body flank tenderness, percussion pain disappears, gallbladder do not lay one's hand on and, spiritual appetite is good.Routine blood test is normal.B ultrasonic shows: gallbladder normal in size, calculus reduces 70% compared with front.Liver function: glutamate pyruvate transaminase, total bilirubin, bilirubin direct is normal.Given antiinflammatory, hepatoprotective and improve coherence check, since taking compound recipe gold sand choleretic granules of the present invention agent (function of gallbladder promoting decoct), after 1 week, symptom is alleviated, and 3 all after date transference cures continue to take and consolidate curative effect 1 course for the treatment of.After 3 years, follow up a case by regular visits to so far without recurrence.

12, Peng XX, man, 70 years old, department: an outer section, address: yellow Po Qianchuanpeng building village, suffer from cholelithiasis more than 25 years, be diagnosed as cholelithiasis, take medicine throughout the year, have no improvement always.On December 28th, 2013, patient is admitted to hospital because of " the interventral disconnected pain in upper right more than 1 year, then send out 1 day ".Enter gate (urgency) diagnosis: acute episode of chronic cholecystitis, cholelithiasis, acute pancreatitis? hypertension.Have a medical check-up: physical examination: 37 DEG C of body temperature, 82 beats/min, pulse (rule), breathes 20 beats/min (rule) blood pressure 180/100mmHg.Admission date: on December 28th, 2013, leave hospital the date: on 01 02nd, 2014.The diagnosis and treatment of being admitted to hospital process: patient is admitted to hospital because of " the interventral disconnected pain in upper right more than 1 year, then send out 1 day ".Case feature: 1. main suit: the interventral disconnected pain in upper right more than 1 year, then send out 1 day; 2. history of present illness: patient occurred right Upper abdominal pain without obvious inducement before 1 year, and was repeatedly interrupted outbreak.Previously once row Abdominal B type ultrasonography inspection prompting cholelithiasis.When morbidity, give anti-inflammatory analgesic symptomatic treatment, stomachache can take a turn for the better.About approximately 1 o'clock this morning, patient sends out Upper abdominal pain right again without obvious inducement, and acomia vomiting due to heat is told and jaundice, without uncomfortable in chest and suffer from diarrhoea.After morbidity, once at Huang Po belt commune hospital row anti-inflammatory analgesic symptomatic treatment, stomachache is without obviously alleviating.Patient is existing to our hospital, and outpatient service is taken in my section's treatment with " acute episode of chronic cholecystitis, cholelithiasis ".After this time morbidity of patient, spiritual diet and poor sleep, defecation Non Apparent Abnormality.3. history of past illness: previously have hypertension history more than 4 years, once had apoplexy medical history before 2 years.Deny drug allergy history.5. training inspection: god is clear, and sclera is not yellow, cardiopulmonary (-), abdomen is flat soft, right upper abdomen tenderness (+), without rebound tenderness, Fei Shi does not levy (+), under liver spleen rib not and, borborygmus is normal, Shuan Shen district is without kowtowing pain, Yu Zheng.6. auxiliary examination: leave hospital and record 1 part in belt commune hospital, December in 2013 Huangpo District on the 28th.Differential Diagnosis: gastric ulcer: left Upper abdominal pain, there is acid regurgitation situation, gastroscopy can be clear and definite.Diagnosis and treatment plan: prohibit diet, give the anti-inflammatory analgesic blood pressure lowering Supporting Therapy of suiting the medicine to the illness, improve abdominal part color ultrasound and blood biochemical coherence check, observe vital sign and change of illness state.Shown in color ultrasound: approximately 8.1 × 3.2cm of gallbladder size, form is normal, sees diameter 0.5cm high light group in capsule, and rear accompanying sound shadow, is separately shown in sticky thick luminous point in capsule.The about 0.6cm of common bile duct epimere internal diameter.Ultrasonic prompting: a large amount of pneumatosis in abdominal cavity; Cholelithiasis, bile thickness; Two renal calculus.Medication: 2013.12.28 0.9% sodium chloride pin 250ml, Cefodizime pin, 2014.1.1 take clinical experience side's compound recipe gold sand choleretic granules agent of the present invention (original name: function of gallbladder promoting decoct) × 10 pairs, prescription consists of: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis. 30.5 grams of Herba Taraxacis.Take 1 dose of every day each 250ml, sooner or later 2 clothes.Serve on 15 pairs.Give to giving antiinflammatory, hepatoprotective and improving coherence check, discharge instructions simultaneously: take a good rest, low fat diet, uncomfortable with examining.Patient is since taking compound recipe gold sand choleretic granules of the present invention agent (original name: function of gallbladder promoting decoct), and 1 all after date symptom is alleviated, and 2 all after date transference cures continue to take and consolidate curative effect 1 course for the treatment of.After half a year, follow up a case by regular visits to without recurrence

13, open XX, man, 68 years old, department: an outer section, address: three Li Qiaoyandi villages, yellow pond, 1. admission date: on May 27th, 2013, patient is admitted to hospital because of " right Upper abdominal pain more than 7 hours ", door (urgency) diagnosis: acute cholecystitis, choledocholithiasis, cholelithiasis, acute cholangitis, emphysema.Line correlation inspection after being admitted to hospital, 40 DEG C of body temperature, 98 beats/min, pulse (irregular), breathes 20 beats/min (rule) blood pressure 110/70mmHg.MRI shows: common bile duct stage casing calculus, and gallbladder Calculus, cholecystitis (fossa for gallbladder edema) rabat shows: chronic bronchitis, emphysema, pulmonary function shows: severe is limited in respiratory disorder, row infection, symptomatic treatment, informs family members' risk, and family members require expectant treatment.2. history of present illness: patient's this morning occurred right Upper abdominal pain on a full stomach about at approximately 3 o'clock in afternoon, companion's vomiting and heating, the uncomfortable in chest and diarrhoea without hematemesis.After morbidity, once checked at Wuhan 161 hospital admission line correlations, not row treatment, its stomachache is without alleviating.Patient is existing to our hospital, and outpatient service is taken in my section's treatment with " acute cholecystitis, cholelithiasis, choledocholithiasis ".After patient morbidity, spiritual diet and sleep poor, defecation Non Apparent Abnormality.3. history of past illness: previously without special medical history, deny drug allergy history.4. training inspection: god is clear, breathes steadily slightly xanthochromia of skin and sclera, cardiopulmonary (-), abdomen is flat soft, right upper abdomen tenderness (+), and without rebound tenderness, Fei Shi does not levy (+), under liver spleen rib not and, hypoactive bowel sounds, Shuan Shen district without kowtow pain, Yu Zheng.5. auxiliary examination: December in 2013 Wuhan 161 hospital's abdominal CT prompting distal common bile duct calculus on the 27th, choledochectasia, cholecystitis cholelithiasis, the multiple pneumatosis of stones in intrahepatic bile duct, left kidney microlith, two lung emphysema.Previously, without special medical history, deny drug allergy history.Routine blood test prompting WBC12.65 × 10 9./L, N97.0%.Blood amylase and lipase are normal.Diagnosis and treatment plan: prohibit diet, give the anti-inflammatory analgesic hepatoprotective Supporting Therapy of suiting the medicine to the illness of bringing down a fever, improve blood biochemical coherence check, observe vital sign and change of illness state.Pulmonary function shows: severe obstruction of pulmonary ventilation, and rabat shows: chronic bronchitis inflammation, emphysema, aortic knob calcification, biliary tract MRI shows: common bile duct stage casing calculus, gallbladder Calculus, cholecystitis, pulmonary dysfunction at present, modern please treatment by Respiratory Medicine, treatment is the same.Color ultrasound shows: liver form is normal, shows no obvious abnormalities signal change in liver parenchyma; Stones in intrahepatic bile duct has no obvious expansion; Common bile duct is expansion slightly, approximately 1.0 × 0.6cm nodositas T2WI low signal of the visible size in common bile duct stage casing; Gallbladder increases, and cyst wall thickens.Common bile duct stage casing calculus; Gallbladder Calculus, cholecystitis (fossa for gallbladder edema) Western medicine diagnose are calculus of bile duct, and tcm diagnosis is hypochondriac pain, and disease belongs to damp-heat type.Rule for the treatment of heat clearing away is soothing the liver, cholagogic and lithagogue.Medication: 27,/12 0.9% sodium chloride pin 250ml, Cefodizime pin skin test, 8/1 compound recipe Spora Lygodii choleretic granules (original name: function of gallbladder promoting decoct × 15 pair), 27/120.9% sodium chloride pin 100ml, Cefodizime pin 2.0g, 0.5% first nitre holder pin 200ml, 0.9% sodium chloride pin 100ml, pantoprazole pin 60mg, 0.9% sodium chloride pin 250ml, diammonium glycyrrhizinate pin 150mg, 0.9% sodium chloride pin 100ml, dimension K 20mg.(special examined numbering: x-ray number: 1350389 No. CT :/No. WEI: 1317621) discharge instructions: bland liquid diet, uncomfortable with examining, consist of since taking compound recipe Spora Lygodii choleretic granules of the present invention (original name: function of gallbladder promoting decoct) prescription: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Take 1 dose of every day each 250ml, sooner or later 2 clothes.After 15 days, symptom is alleviated, and transference cure after 3 courses for the treatment of continues to take and consolidates curative effect 3 courses for the treatment of.The recurrence of following up a case by regular visits to afterwards more than a year that so far there are no.

14, Wu XX, female, 70 years old, department: an outer section, source village, Huang Po Cai Dian street, Xian Zhu Hubei Province, within on 01 12nd, 2013, patient is because of " epigastrium pain 2 days." be admitted to hospital.1, previously have glaucoma for many years blind, for many years, the trauma history of denying performing the operation, blood transfusion history, medicine food anaphylaxis history, deny hepatitis, schistosomicide medical history to colitis medical history.Row fluid infusion, infection, symptomatic treatment.2., history of present illness: patient is without obvious inducement sense epigastrium pain before 2 days, and companion's vomiting once, is gastric content, non-spurting, companion fear of cold, heating, without stupor, uncomfortable in chest, cough, tachypnea, melena, once at local row infusion treatment, without taking a turn for the better, seek medical advice to my institute, the income to be checked of suffering from abdominal pain institute.Leave hospital the date: on 01 15th, 2014.3, AD: to be checked, the acute cholecystitis of suffering from abdominal pain, acute pancreatitis? left renal calculus.4. physical examination: 36.8 DEG C of body temperature, 86 beats/min, pulse (rule), breathes 20 beats/min (rule), and blood pressure 140/70mmHg god is clear, neck is soft, and cardiopulmonary are without extremely, and abdomen is flat soft, epigastrium tenderness, without rebound tenderness, a little less than borborygmus, two lower limb are without swelling; 5. training inspection: god is clear, and neck is soft, cardiopulmonary are without extremely, epigastrium tenderness, without rebound tenderness, a little less than borborygmus, two lower limb are without swelling.6. auxiliary examination: electrocardio diagram: sinus rhythm, QT interval prolongation, color ultrasound is shown: gallbladder increases, left kidney is slight hydrops, gallbladder is assisted calculus, and ventral aorta color ultrasound is shown: ventral aorta can display segment atherosclerosis plaque forming.7, liver function test: patient tells stomachache and slightly alleviates, vomiting once, is gastric content, non-spurting, health check-up is the same, and routine blood test shows just now: leukocyte etc. show undesired, three of heart infarction, myocardial enzymes is normal.Director Zhu indicates after checking patient: patient exists obstructive jaundice at present, intestinal infection, and liver function damage, hypokalemia, provisional symptomatic treatment, row biliary tract MRCP checks.8, color ultrasound prompting: ventral aorta is can display segment inner membrance rough, and tube wall is slightly thick, and lumen diameter 1.6cm is shown in it that being dispersed in high light speckle adheres to, and color Doppler shows, blood flow continuous whole in tube chamber, regular edges, no abnormality seen blood flow signal.Pneumoperitoneum part sections shows unclear.9, medication: 27,/12 0.9% sodium chloride pin 250ml, Cefodizime pin 1g, 15/1 (skin test is qualified), 8/1 oral administered compound Spora Lygodii choleretic granules (original name: function of gallbladder promoting decoct × 15 pair) prescription consists of: 15.5 grams of Herba Lysimachiaes, 30.5 grams of Herba Plantaginiss, 15.5 grams of Spora Lygodii (cloth bag), 15.5 grams of Herba Artemisiae Scopariaes, 15.5 grams of the Radix Paeoniae Albas, 15.5 grams of Fructus Toosendans, 10.5 grams of Rhizoma Pinelliae Preparatum, 10.5 grams of Radix Et Rhizoma Rhei (under rear), 10.5 grams of Radix Curcumaes, 15.5 grams of Radix Bupleuri, 15.5 grams of Radix Scutellariaes (under rear), 10.5 grams of Fructus Aurantiis, 30.5 grams of Herba Taraxacis.Take 1 dose of every day each 250ml, sooner or later 2 clothes.27/12 0.9% sodium chloride pin 100ml, Cefodizime pin 2.0g, 0.5% first nitre holder pin 200ml, 0.9% sodium chloride pin 100ml, pantoprazole pin 60mg, 0.9% sodium chloride pin 250ml, diammonium glycyrrhizinate pin 150mg, 0.9% sodium chloride pin 100ml, dimension K 20mg.Continue and take 15 doses, all diseases are all removed, and enter again 5 pairs, as a means of consolidation.After taking 35 doses of function of gallbladder promoting decocts of the present invention, symptom is alleviated, and transference cure after 3 courses for the treatment of, continues to take and consolidate curative effect 3 courses for the treatment of.After more than 1 year, follow up a case by regular visits to check abdominal part and urinary system color ultrasound so far there are no recurrence.

Preparation Example is amplified in pilot scale

Embodiment 1: 15.5 kilograms of Herba Lysimachiaes, 30.5 kilograms of Herba Plantaginiss, 15.5 kilograms of Spora Lygodii (cloth bag), 15.5 kilograms of Herba Artemisiae Scopariaes, 15.5 kilograms of the Radix Paeoniae Albas, 155 kilograms of Fructus Toosendans, 10.5 kilograms of Rhizoma Pinelliae Preparatum, 10.5 kilograms of Radix Et Rhizoma Rhei (under rear), 10.5 kilograms of Radix Curcumaes, 15.5 kilograms of Radix Bupleuri, 15.5 kilograms of Radix Scutellariaes (under rear), 10.5 kilograms of Fructus Aurantiis, 30.5 kilograms of Herba Taraxacis; Wherein process for producing granula is:

Get 11 taste medical materials except Radix Et Rhizoma Rhei, Radix Scutellariae, add 10-15 times of water, soak after 20-40 minute, heating extraction, extracts 2-4 time, each 0.5-2 hour that decocts, Radix Scutellariae the 2nd time extract time, and more than 70 DEG C, under condition, after immersion treatment, add extract 0.5-2h be optimised process, merge extractive liquid,, filter, be concentrated into the thick paste that 25 DEG C of density are 1.20g/ml for subsequent use; It is for subsequent use that Radix Et Rhizoma Rhei was pulverized 100 mesh sieves; , be mixed and made into dried cream powder with 12 kinds of extractum and feed intake, separately getting dextrin and lactose ratio is 1.5: 1, equivalent incremental method mix homogeneously, add 0.5% aspartame, by raw material, adjuvant mix homogeneously, make soft material using 75% ethanol as diluent, thick paste and the adjuvant ratio of 1: 2.5 is mixed, and with 12 mesh sieve wet granulations, 80 DEG C following fully dry, granulate, pack and get final product, obtain finished particle agent of the present invention.

Embodiment 2: a kind of Chinese medicine composition according to claim 4, wherein the preparation method of tablet is:

Get 11 taste medical materials except Radix Et Rhizoma Rhei, Radix Scutellariae: 15.5 kilograms of Herba Lysimachiaes, 30.5 kilograms of Herba Plantaginiss, 15.5 kilograms of Spora Lygodii (cloth bag), 15.5 kilograms of Herba Artemisiae Scopariaes, 15.5 kilograms of the Radix Paeoniae Albas, 155 kilograms of Fructus Toosendans, 10.5 kilograms of Rhizoma Pinelliae Preparatum, 10.5 kilograms of Radix Et Rhizoma Rhei (under rear), 10.5 kilograms of Radix Curcumaes, 15.5 kilograms of Radix Bupleuri, 15.5 kilograms of Radix Scutellariaes (under rear), 10.5 kilograms of Fructus Aurantiis, 30.5 kilograms of Herba Taraxacis; Add 10-15 times of water, soak after 20-40 minute, heating extraction, extracts 2-4 time, decocts 0.5-2 hour at every turn, Radix Scutellariae is in the time extracting for the 2nd time, and more than 70 DEG C, under condition, after immersion treatment, add extract 0.5-2h be optimised process, merge extractive liquid,, filter, be concentrated into the thick paste that 25 DEG C of density are 1.20g/ml, it is for subsequent use that Radix Et Rhizoma Rhei was pulverized 100 mesh sieves; , be mixed and made into dried cream powder with 12 kinds of extractum and feed intake, separately getting dextrin and lactose ratio is 1.5: 1, equivalent incremental method mix homogeneously, add 0.5% aspartame, by raw material, adjuvant mix homogeneously, make soft material using 75% ethanol as diluent, thick paste and the adjuvant ratio of 1: 2.5 is mixed, and with 12 mesh sieve wet granulations, 80 DEG C following fully dry, tabletting, had both obtained finished tablet of the present invention.

Embodiment 3: a kind of Chinese medicine composition according to claim 4, wherein the preparation method of capsule is:

Get except Radix Et Rhizoma Rhei, 15 kilograms of the outer 11 taste medical material Herba Lysimachiaes of Radix Scutellariae, 30,000 parts of Herba Plantaginiss, 30 kilograms of Spora Lygodii (cloth bag), 15 kilograms of Herba Artemisiae Scopariaes, 15 kilograms of the Radix Paeoniae Albas, 15 kilograms of Fructus Toosendans, 10 kilograms of Rhizoma Pinelliae Preparatum, 10 kilograms of Radix Et Rhizoma Rhei (under rear), 10 kilograms of Radix Curcumaes, 15 kilograms of Radix Bupleuri, 15 kilograms of Radix Scutellariaes, 10 kilograms of Fructus Aurantiis, 30 kilograms of Herba Taraxacis, add 10-15 times of water, soak after 20-40 minute, heating extraction, extract 2-4 time, each 0.5-2 hour that decocts, Radix Scutellariae is in the time extracting for the 2nd time, and more than 70 DEG C, under condition, after immersion treatment, add extract 0.5-2h be optimised process, merge extractive liquid, filter, be concentrated into the thick paste that 25 DEG C of density are 1.20g/ml, it is for subsequent use that Radix Et Rhizoma Rhei was pulverized 100 mesh sieves, be mixed and made into dried cream powder with 12 kinds of extractum and feed intake, separately getting dextrin and lactose ratio is 1.5: 1, equivalent incremental method mix homogeneously, add 0.5% aspartame, by raw material, adjuvant mix homogeneously,, make soft material using 75% ethanol as diluent, thick paste and the adjuvant ratio of 1: 2.5 is mixed, with 12 mesh sieve granulation wet granulations, 80 DEG C of oven dry, granulate and get final product.

Ethanol using 75% is made soft material as diluent,, thick paste and the adjuvant ratio of 1: 2.5 is mixed, with 12 mesh sieve wet granulations, 80 DEG C are following fully dry, add lubricant, encapsulated, both both must finished capsule product agent of the present invention.

Embodiment 4: get 15 kilograms of Herba Lysimachiaes, 30,000 parts of Herba Plantaginiss, 30 kilograms of Spora Lygodii (cloth bag), 15 kilograms of Herba Artemisiae Scopariaes, 15 kilograms of the Radix Paeoniae Albas, 15 kilograms of Fructus Toosendans, 10 kilograms of Rhizoma Pinelliae Preparatum, 10 kilograms of Radix Et Rhizoma Rhei (under rear), 10 kilograms of Radix Curcumaes, 15 kilograms of Radix Bupleuri, 15 kilograms of Radix Scutellariaes, 10 kilograms of Fructus Aurantiis, 30 kilograms of Herba Taraxacis.Fully mixed Uniform, soaks 45 minutes, and steaming and decocting twice in extraction pot continues steaming and decocting 60 minutes after each boiling, merges twice filtrate, and quiescent setting 10 hours, gets supernatant steaming and decocting and be concentrated into 500L, is distributed into bottle; Then vapor sterilization 30 minutes, is finished product decoct of the present invention.Instructions of taking: every day 500ml, at twice clothes.

Compound recipe Spora Lygodii choleretic granules agent acute toxicity testing and pharmacodynamic study:

A kind of Chinese medicine composition according to claim 4, acute toxicity testing and pharmacodynamic study: be according to process for producing granula wherein, the safety of medicine to be made an appraisal:

Acute toxicity testing and pharmacodynamic study: toxicological study is to make an appraisal for the safety of medicine, is divided into acute toxicity testing and long term toxicity test.The research purpose of animal acute toxicity experiment mainly contain illustrate medicine toxic action, understand the design considerations of dosage and the reference of clinical experiment initial dose with reference to, pharmacodynamic study of its toxicity target organ, long term toxicity test dosage.This chapter by the investigation to acute toxicity testing, observes dealed with medicine went, and provides reference frame for the dosage design of pharmacodynamic experiment.A kind of Chinese medicine composition compound recipe of the present invention Spora Lygodii choleretic granules agent prescription consists of: 15 grams of Herba Lysimachiaes, 30 grams of Herba Plantaginiss, 30 grams of Spora Lygodii, 15 grams of Herba Artemisiae Scopariaes, 15 grams of the Radix Paeoniae Albas, 15 grams of Fructus Toosendans, 10 grams of Rhizoma Pinelliae Preparatum, 10 grams of Radix Et Rhizoma Rhei (under rear), 10 grams of Radix Curcumaes, 15 grams of Radix Bupleuri, 15 grams of Radix Scutellariaes, 10 grams of Fructus Aurantiis, 30 grams of Herba Taraxacis.Get 11 taste medical materials except Radix Et Rhizoma Rhei and add 10-15 times of water, soak after 20-40 minute, heating extraction, extract 2-4 time, decoct 0.5-2 hour at every turn, Radix Scutellariae is in the time extracting for the 2nd time, and more than 70 DEG C, under condition, after immersion treatment, add extract 0.5-2h be optimised process, merge extractive liquid,, filters, and is concentrated into the thick paste that 25 DEG C of density are 1.20g/ml for subsequent use; It is for subsequent use that Radix Et Rhizoma Rhei was pulverized 100 mesh sieves, being mixed and made into dried cream powder with 12 kinds of extractum feeds intake, separately getting dextrin and lactose ratio is 1.5: 1, and equivalent incremental method mix homogeneously, adds 0.5% aspartame, and by raw material, adjuvant mix homogeneously, ethanol using 75% is made soft material as diluent, and thick paste and the adjuvant ratio of 1: 2.5 is mixed, with 12 mesh sieve granulation wet granulations, 80 DEG C of oven dry, granulate and get final product.

This problem prescription is clinical experience side for many years in institute of Huangpo District the People's Hospital, determined curative effect aspect treatment cholelithiasis and cholecystitis.Motherland's medical science thinks, cholelithiasis belongs to the traditional Chinese medical science " hypochondriac pain " " blocked-up chest ", and " jaundice " waits disease category.The formation of cholelithiasis, is because of irritability stasis, and bile loses in catharsis, and shaoyang channel arteries and veins is unfavorable, strongly fragrant and fire-transformation or have a liking for food delicious food, and long-pending humidogene heat, intimately stifling, decoct bile, poly-and calculogenesis, gallbladder network is hindered, stagnation of QI and blood may bring about pain so that hypochondriac pain poor appetite, very person's jaundice.Therefore cholelithiasis be wet, heat, become silted up three heresies interweave for suffer from, disease located in liver gallbladder, the state of an illness belongs to the excess syndrome of depression of liver-QI.Therefore treat with depressed liver-energy dispersing and QI regulating, clearing away heat-damp and promoting diuresis, cholagogic and lithagogue is main.Therefore this chapter investigates compound recipe Spora Lygodii choleretic granules from antiinflammation and choleretic effect.

Compound recipe Spora Lygodii choleretic granules agent acute toxicity testing

1.1 laboratory animal

60 of SPF level Kunming kind healthy mices, male and female half and half, body weight 18-22g, is provided by Animal Experimental Study center, Hubei Province, credit number: SCXK (Hubei Province) 2008-0005, the animal quality certification number: 42000600002761; 42000600002865.Before all zooperies, use after one week in HuaZhong Science University, TongJi medical school, TongJi Hospital Experimental Animal Center adaptability observation.

1.2 experimental technique

1.2.1 tested medicine preparation

Give the thick paste that 20 DEG C of lower densities are 1.20g/ml (recipe quantity crude drug extracts the concentrated 75ml that is about by optimum extraction process) through preliminary experiment by the volume of 0.4ml/10g, finding that thick paste is too dense cannot gastric infusion, therefore preparation prescription amount crude drug extracts and is condensed into 100ml solution as maximum dosage by optimum extraction process, be that concentration is 2.04g/ml (by the maximum volume gastric infusion of mice 0.4ml/10g, concentration is 81.6g/kg).

1.2.2 half fatality rate (LD50) is measured

Get fasting and can't help water 12 hours, 20 of body weight 18-22g mices, male and female half and half, are divided into high dose group (a group) and low dose group (b group) at random, and 10 every group, male and female half and half.Each group is administered once by 0.4ml/10g, and a group gives the compound recipe Spora Lygodii choleretic granules solution that concentration is 81.6g/kg, and b group gives the compound recipe Spora Lygodii choleretic granules solution that concentration is 40.8g/kg.The toxic reaction of Continuous Observation 12 hour record mices after administration, observes in 14 days and records dead mouse situation.

1.2.3 maximum dosage-feeding is measured

Get fasting and can't help water 12 hours, 40 of body weight 18-22g mices, male and female half and half, are divided into administration group (c group) and blank group (d group) at random, and 20 every group, male and female half and half.Each group is administered once by 0.4ml/10g, and c group gives the compound recipe Spora Lygodii choleretic granules solution that concentration is 81.6g/kg, and d group gives distilled water.3 (every minor ticks 6 hours of administration in 24 hours, after administration, give feedstuff, before rear twice administration, fasting be can't help water 3 hours), after administration, Continuous Observation 24 hour records are respectively organized toxic reaction and the death condition of mice, Continuous Observation 7 days, records the weight of animals, appetite, outward appearance, behavioral activity and death condition.Can't help water in experiment fasting last day and put to death mice after 12 hours, dissect, whether the main organs c groups such as observation mouse core, liver, spleen, lung, kidney and d group change, and before and after t inspection comparative test, each Mouse Weight of organizing changes.

1.3 experimental result

1.3.1 half fatality rate (LD50) measurement result

Within the observation period, after the administration of A group mice, show movable minimizing, look asthenia, after administration, after half an hour, this phenomenon fades away; After the administration of B group mice without any extremely.Two groups of mices are all without abnormal jump behavior, non-stimulated responsive sign, mouthful, there is not abnormal secretion thing in eye, nose, diet, drinking-water, defecation are all normal, respiratory activity is normal, has no dead, fails to measure LD ₅₀.The results are shown in Table 4-1.

The table 4-1 compound recipe Spora Lygodii choleretic granules mice oral administration LD of team ₅₀measure

1.3.2 maximum dosage-feeding is measured

Within the observation period, after the administration of administration group mice, show movable minimizing, look asthenia, after administration, after about half an hour, this phenomenon fades away.Without dead mouse, behavior, appetite, outward appearance, excretion are all without abnormal, and administration is Mouse Weight normal growth after 7 days, put to death the major organs such as dissection after mice, its heart of perusal, liver, spleen, lung, kidney and digestive tract and organize no abnormality seen phenomenon.The results are shown in Table 4-2.

Table 4-2 compound recipe Spora Lygodii choleretic granules is measured mice oral administration maximum dosage-feeding

2 compound recipe Spora Lygodii choleretic granules agent antiinflammatory experiments

The multiple oral administered compound gold sand choleretic granules agent (original name: function of gallbladder promoting decoct) of a kind of Chinese medicine composition of the present invention adds taste prescription and consists of: Herba Lysimachiae 15.5g, Spora Lygodii (cloth bag) 15.5g, Herba Artemisiae Scopariae 15.5g, Radix Paeoniae Alba 15.5g, Fructus Toosendan 15.5g, Rhizoma Pinelliae Preparatum 10.5g, Radix Et Rhizoma Rhei (under rear) 10.5g, Radix Curcumae 15.5g, Radix Bupleuri 10.5g, Radix Scutellariae 15.5g, Fructus Aurantii 15.5g, Herba Plantaginis 30.5g, Herba Taraxaci 310.5g.

2.1 experiment material

2.1.1 laboratory animal

50 of SPF level Kunming kind healthy mices, male and female half and half, body weight 18-22g, is provided by Animal Experimental Study center, Hubei Province, credit number: SCXK (Hubei Province) 2008-0005, the animal quality certification number: 42000600002927.Before all zooperies, within 3 days, use in HuaZhong Science University, TongJi medical school, TongJi Hospital Experimental Animal Center adaptability observation.

2.1.2 experimental drug and reagent

XIAOYAN LIDAN PIAN (Guangdong Luofushan Sinopharm Co., Ltd., lot number: L13K195);

Dimethylbenzene is analytical pure

2.2 experimental technique

Get fasting and can't help water 12 hours, 50 of body weight 18-22 mices, are divided into 5 groups at random, and 10 every group, male and female half and half.Gastric infusion, blank group gives 0.616g/kg XIAOYAN LIDAN PIAN and removes coating to 40ml/kg distilled water, low dose group administration 8.16g crude drug/kg, middle dosage group administration 16.32g crude drug/kg, high dose group administration 32.64g crude drug/kg, positive controls.Successive administration 7 days, after administration 1 hour the last time, be close to the left auricle of mice with the circular filter paper sheet that soaks into dimethylbenzene and cause inflammation 15 seconds, after 30 minutes, put to death mice, the card punch that is 9mm with diameter takes off auricle at the same position of mice left and right ear respectively, the weight of precision weighing left and right auricle, of poor quality as swelling using left and right auricle, with the significance of the more each group difference of t method of inspection, calculate inhibitory rate of intumesce: suppression ratio (%)=[1-(administration group two auricles are of poor quality/and blank group two auricles are of poor quality)] × 100%.The results are shown in Table 4-3.

2.3 experimental result

The impact of table 4-3 compound recipe Spora Lygodii choleretic granules xylol induced mice ear swelling

Note: with the comparison of blank group, * P < 0.05; * P < 0.01

Result shows, high, the middle dosage group of compound recipe Spora Lygodii choleretic granules and positive controls all have the effect that suppresses dimethylbenzene induced mice ear swelling, effect is remarkable, relatively has statistical significance (P < 0.05 or P < 0.01) with blank group; Although compound recipe Spora Lygodii choleretic granules low dose group also has the effect that suppresses dimethylbenzene induced mice ear swelling, relatively there is no statistical significance (P > 0.05) with blank group.

3 compound recipe Spora Lygodii choleretic granules agent cholagogic experiments

3.1 experiment material

3.1.1 laboratory animal

10 of SPF level male SD rats, body weight 200-220g, is provided by Animal Experimental Study center, Hubei Province, credit number: SCXK (Hubei Province) 2008-0005, the animal quality certification number: 42000600003193.Before all zooperies, within 3 days, use in HuaZhong Science University, TongJi medical school, TongJi Hospital Experimental Animal Center adaptability observation.

3.1.2 reagent

XIAOYAN LIDAN PIAN (Guangdong Luofushan Sinopharm Co., Ltd., lot number: L13K195);

Urethane is analytical pure

3.2 experimental technique

Get 10 of 200-220g male SD rats, be divided at random 5 groups, before experiment, water 12h is can't help in fasting, lumbar injection urethane (1g/kg) anesthesia, dorsal position is fixed, under xiphoid-process, 3cm opens abdomen, in descendant duodenum mesentery, finds bile duct, separates, duodenum end is entered in ligation, insert PE-10 pipe, see that having faint yellow bile to flow out rear ligation fixes, and manages and collects bile 30min with EP.Respectively organize according to dosage respectively by duodenal administration afterwards, after collect respectively bile in 30min, 60min, 90min, totally 4 times, record the bile flow of each time period.The results are shown in Table 4-4.

3.3 experimental result

The impact of table 4-4 compound recipe Spora Lygodii choleretic granules on bile flow ( n=2)

Result shows, the basic, normal, high dosage group of compound recipe Spora Lygodii choleretic granules and positive controls are compared with blank group, have increase at 30min, 60min, 90min bile flow, show that discharge has facilitation to compound recipe Spora Lygodii choleretic granules to bile, prompting medicine has choleretic effect to rat.

4. analyze and discuss

Compound recipe Spora Lygodii choleretic granules is pure Chinese medicinal preparation, owing to cannot measuring half fatality rate, therefore carry out compound recipe Spora Lygodii choleretic granules solution, the oral maximum dosage-feeding of mice is measured.Test does not have overt toxicity reaction to laboratory animal finally, show that the tolerant maximum dosage-feeding of mice is 244.8g crude drug/kg, for 7.5 times of high dose group in pharmacodynamics in Mice experiment (antiinflammatory experiment high dose group every day take crude drug 32.64g/kg), therefore compound recipe Spora Lygodii choleretic granules oral administration safety.

Gallbladder intracystic stones blocks suddenly or incarceration cystic duct is the common cause that causes acute cholecystitis, and cystic duct reverses, narrow and biliary tract ascarid or tumor of biliary tract block and also can cause acute cholecystitis.And no matter chronic cholecystitis is to have close contact in pathogenesis and disease, it merges the category such as " hypochondriac pain ", " feeling of fullness " that cholelithiasis belongs to the traditional Chinese medical science., at gallbladder, there is close relationship sick position with spleen, liver stomach.Therefore, in treatment, the two complements each other, the combined effect of calculus cholagogue and eliminating inflammation.

Dimethylbenzene, as chemical proinflammatory agent, can cause some inflammatory mediator, as the release of histamine, kassinin kinin and fibrinoclase.The release of these media can cause the increase of local capillary permeability and the infiltration of inflammatory cell, causes the acute exudative inflammatory edema of ear.Therefore acute inflammation model often brings out the swelling of mice auricular concha and verifies the antiinflammatory action of medicine with proinflammatory agent dimethylbenzene.

Result of study shows, compound recipe Spora Lygodii choleretic granules xylol brings out mice ear and has certain inhibitory action, explanation can be played by suppressing dimethylbenzene effect the effect of inflammation-inhibiting, its mechanism may be to suppress the increase of local capillary permeability and the infiltration of inflammatory cell, it may be the effect by suppressing histamine, kassinin kinin and fibrinoclase, also may be the release of promotion histamine, kassinin kinin and fibrinoclase by suppressing dimethylbenzene, thereby inflammation-inhibiting, alleviates inflammatory swelling.

Bile is synthetic in liver, secretes to biliary tract by biliary ductuli, be stored in gallbladder, and process is concentrated in gallbladder.On the feed, under the stimulation of the lipid of especially taking food food, gallbladder contraction, bile excretion to duodenum plays a role.Whether relevant the secretion of bile and the situation of excretion be normally to liver, gallbladder and biliary tract function of patients, and the normal transport of bile can promote the discharge of microlith and inflammatory mediator in biliary tract, plays the effect of common biliary tract, protection biliary tract.Variously cause the disease of bile secretion, acatharsia all can destroy biliary tract normal function, cause various biliary tract.In human body, the flow velocity of bile is relevant to its secretion speed and the mechanism in gallbladder, and rat lacks gallbladder, can be by the function of the flow velocity direct reaction hepatic secretion bile of bile.

The demonstration of this experimental result, compound recipe Spora Lygodii choleretic granules can obviously improve the flow of bile under test dose, accelerates hepatic secretion bile, and prompting compound recipe Spora Lygodii choleretic granules can promote the discharge of bile, plays choleretic effect.But because sample size is few, cannot be from the variable quantity of statistics objective analysis rat bile flow, this experiment is as the preliminary experiment of cholagogic experiment, and the choleretic effect of further studying compound recipe Spora Lygodii choleretic granules for the later stage provides reference and foundation.

Compound recipe Spora Lygodii choleretic granules (former function of gallbladder promoting decoct) be in the institute of Huangpo District, Wuhan City the People's Hospital through proved recipe, calculus cholagogue and eliminating inflammation is had to good curative effect, be the cipher prescription of institute's internal therapy cholecystitis and cholelithiasis.This experiment is to improve on the basis of original dosage form, tests several aspects compound recipe Spora Lygodii choleretic granules is studied from preparation technology, quality control, acute toxicity testing and Pharmacodynamics.

1. the Main Conclusions of this experiment

Compound recipe Spora Lygodii choleretic granules is by the analysis of the pharmacology to each flavour of a drug ingredient, drug effect, physicochemical property, simultaneously in conjunction with clinical practice, investigate through many index comprehensives, designing its preparation technology is: prescription medical material decocts with water except Radix Et Rhizoma Rhei etc., add 12 times of water (extract and supply water absorption for the first time, add 16 times of water, soak 60 minutes) at every turn, extract 2 times, decoct 1 hour at every turn.Radix Et Rhizoma Rhei is put in the time extracting 40 minutes for the second time.Merge extractive liquid,, filters, and the thick paste that under simmer down to room temperature, (25 DEG C) density is 1.20g/ml, adds 0.5% aspartame, and getting dextrin and lactose ratio is 2: 1, and equivalent incremental method mix homogeneously, makes mixed accessories.Thick paste mixes in (1: 1.5) ratio with adjuvant, adds 85% ethanol as diluent, wet granulation, 80 DEG C of bake dryings, granulate and get final product.

In order to obtain safe, effective, stable preparation, this problem is studied qualitative identification and the assay of compound recipe Spora Lygodii choleretic granules.In qualitative identification, determined with thin layer chromatography and differentiated Radix Paeoniae, Radix Scutellariae, 3 kinds of medical materials of Fructus Aurantii in prescription, gained thin layer chromatography speckle separating degree is good, clear spot, and negative sample is noiseless, shows that the method specificity is good.Assay adopts the content of peoniflorin in high effective liquid chromatography for measuring 3 batch samples, measurement result shows, HPLC detection method is easy, favorable reproducibility, highly sensitive, can be used as one of quality control index, according to measurement result, tentative paeoniflorin content must not be less than 0.8mg/g.

In order to inquire into the drug safety of compound recipe Spora Lygodii choleretic granules oral administration, in the situation that cannot measuring the fatality rate of preparation half, this problem has been carried out the mensuration of the maximum dosage-feeding of medicine to mice, test does not have overt toxicity reaction to laboratory animal finally, show that the tolerant maximum dosage-feeding of mice is 244.8g (crude drug)/kg, for 7.5 times of high dose group in pharmacodynamics in Mice experiment (antiinflammatory experiment high dose group every day take crude drug 32.64g/kg), therefore compound recipe Spora Lygodii choleretic granules oral administration safety.Compound recipe Spora Lygodii choleretic granules has been carried out to pharmacodynamics investigation simultaneously, experimental result shows can obviously suppress auricle edema due to mice dimethylbenzene under test dose, and can obviously improve the flow of bile, and accelerate hepatic secretion bile, point out its antiinflammation and choleretic effect.

List of references:

[1] Liu Yafang, the cause of disease, clinical manifestation and diagnosis " the Chinese doctor of community " 47 phases in 2011 of acute and chronic cholecystitis

[2] surgery of Chinese Medical Association branch, the diagnosis that acute biliary tract system infects and Chinese digestive surgery magazine 2011,2 (10) 1:9-13 for the treatment of guide (2011 editions)

[3] Guo Jianguo. brief talk differential diagnosis in tcm opinion and control cholelithiasis [J]. the journal .2003 of Qinghai Medicine College, 3 (24): 182-183.

[4]Bolondi?L，Gaiani?S，Testa?S，Labò?G.Gall?bladder?sludge?formation?during?prolonged?fasting?after?gastrointestinal?tract?surgery.Gut.1985；26：734-8.

[5]Zhao?J，Davis?LC，Verpoorte?R.Elicitor?signal?transduction?leading?to?production?of?plant?secondary?metabolites.Biotechnol?Adv.2005?Jun；23(4)：283-333.

[6]Yeh?TH，Krauland?L，Singh?V，Zou?B，Devaraj?P，Stolz?DB，Franks?J，Monga?SP，Sasatomi?E，Behari?J.Liver-specific?β-catenin?knockout?mice?have?bile?canalicular?abnormalities，bile?secretory?defect，and?intrahepaticcholestasis.Hepatology.2010?Oct；52(4)：1410-9.

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Chinese medicine composition of the present invention and pharmaceutical formulation composition thereof and component source and prescription proportioning are as follows:

Claims (9)

1. a Chinese medicine composition, is characterized in that Chinese medicine composition comprises: Herba Lysimachiae 10-30 weight portion, Spora Lygodii 10-30 weight portion, Herba Artemisiae Scopariae 10-30 weight portion, Radix Paeoniae Alba 10-30 weight portion, Fructus Toosendan 10-30 weight portion, Rhizoma Pinelliae Preparatum 5-15 weight portion, Radix Et Rhizoma Rhei 5-15 weight portion, Radix Curcumae 5-15 weight portion, Radix Bupleuri 10-30 weight portion, Radix Scutellariae 10-30 weight portion, Fructus Aurantii 5-15 weight portion, Herba Plantaginis 20-40 weight portion, Herba Taraxaci 20-40 weight portion.

2. a kind of Chinese medicine composition according to claim 1, wherein Chinese medicine composition comprises: Herba Lysimachiae 15.5 weight portions, Spora Lygodii 15.5 weight portions, Herba Artemisiae Scopariae 15.5 weight portions, the Radix Paeoniae Alba 15.5 weight portions, Fructus Toosendan 15.5 weight portions, Rhizoma Pinelliae Preparatum 10.5 weight portions, Radix Et Rhizoma Rhei 10.5 weight portions, Radix Curcumae 10.5 weight portions, Radix Bupleuri 10.5 weight portions, Radix Scutellariae 15.5 weight portions, Fructus Aurantii 10.5 weight portions, Herba Plantaginis 30.5 weight portions, Herba Taraxaci 30.5 weight portions.

3. a kind of Chinese medicine composition according to claim 1 and 2, is characterized in that Chinese medicine composition is prepared into pharmaceutical preparation.

4. a kind of Chinese medicine composition according to claim 4, wherein pharmaceutical preparation comprises tablet, capsule and granule.

5. the application of a kind of Chinese medicine composition according to claim 1 and 2 in preparation treatment cholecystitis, cholelithiasis medicine.

6. a kind of Chinese medicine composition according to claim 4, wherein process for producing granula is:

Get 11 taste medical materials except Radix Et Rhizoma Rhei, Radix Scutellariae and add 10-15 times of water, soak after 20-40 minute, heating extraction, extract 2-4 time, decoct 0.5-2 hour at every turn, Radix Scutellariae is in the time extracting for the 2nd time, and more than 70 DEG C, under condition, after immersion treatment, add extract 0.5-2h be optimised process, merge extractive liquid,, filters, and is concentrated into the thick paste that 25 DEG C of density are 1.20g/ml for subsequent use; It is for subsequent use that Radix Et Rhizoma Rhei was pulverized 100 mesh sieves, being mixed and made into dried cream powder with 12 kinds of extractum feeds intake, separately getting dextrin and lactose ratio is 1.5: 1, and equivalent incremental method mix homogeneously, adds 0.5% aspartame, by raw material, adjuvant mix homogeneously, ethanol using 75% is as diluent, and thick paste and the adjuvant ratio of 1: 2.5 is mixed, wet granulation, 80 DEG C of oven dry, granulate and get final product.

7. a kind of Chinese medicine composition according to claim 4, wherein the preparation method of tablet is:

Get except Radix Et Rhizoma Rhei, the outer 11 taste medical materials of Radix Scutellariae add 10-15 times of water, soak after 20-40 minute, heating extraction, extract 2-4 time, each 0.5-2 hour that decocts, Radix Scutellariae is in the time extracting for the 2nd time, and more than 70 DEG C, under condition, after immersion treatment, add extract 0.5-2h be optimised process, merge extractive liquid, filter, be concentrated into the thick paste that 25 DEG C of density are 1.20g/ml, it is for subsequent use that Radix Et Rhizoma Rhei was pulverized 100 mesh sieves, being mixed and made into dried cream powder with 12 kinds of extractum feeds intake, separately getting dextrin and lactose ratio is 1.5: 1, equivalent incremental method mix homogeneously, add 0.5% aspartame, by raw material, adjuvant mix homogeneously, ethanol using 75% is as diluent, thick paste and the adjuvant ratio of 1: 2.5 is mixed, wet granulation, 80 DEG C of oven dry, tabletting, both.

8. a kind of Chinese medicine composition according to claim 4, wherein the preparation method of capsule is:

Get except Radix Et Rhizoma Rhei, the outer 11 taste medical materials of Radix Scutellariae add 10-15 times of water, soak after 20-40 minute, heating extraction, extract 2-4 time, each 0.5-2 hour that decocts, Radix Scutellariae is in the time extracting for the 2nd time, and more than 70 DEG C, under condition, after immersion treatment, add extract 0.5-2h be optimised process, merge extractive liquid, filter, be concentrated into the thick paste that 25 DEG C of density are 1.20g/ml, it is for subsequent use that Radix Et Rhizoma Rhei was pulverized 100 mesh sieves, being mixed and made into dried cream powder with 12 kinds of extractum feeds intake, separately getting dextrin and lactose ratio is 1.5: 1, equivalent incremental method mix homogeneously, add 0.5% aspartame, by raw material, adjuvant mix homogeneously, ethanol using 75% is as diluent, thick paste and the adjuvant ratio of 1: 2.5 is mixed, wet granulation, 80 DEG C of oven dry, add lubricant, encapsulated, both.

9. a kind of Chinese medicine composition according to claim 4, wherein the preparation method of decoction is:

Get 11 taste medical materials except Radix Et Rhizoma Rhei, Radix Scutellariae and add 10-15 times of water, soak after 20-40 minute, in extraction pot heating extraction twice, extract 2-4 time, decoct 0.5-2h at every turn; Radix Et Rhizoma Rhei, Radix Scutellariae, in the time extracting for the 2nd time, and add after immersion treatment under condition more than 70 DEG C that to extract 0.5-2h be optimised process, and merge extractive liquid,, filters, and quiescent setting 10 hours is got the fill heat-sealing while being 1.08g/ml of supernatant concentration to density; Be decocted in water for oral dose 1 dose of every day, each 150ml point takes for 2 times sooner or later, is decoction.