CN106822786A - Treat the Chinese herbal granules of non-alcoholic fatty liver disease - Google Patents
Treat the Chinese herbal granules of non-alcoholic fatty liver disease Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/884—Alismataceae (Water-plantain family)
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- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The invention discloses a kind of Chinese herbal granules for treating non-alcoholic fatty liver disease, its raw material such as including the red sage root, rhizoma alismatis, radix bupleuri, gynostemma pentaphylla, turmeric, raw hawthorn, the vine of multiflower knotweed, fructus polygoni orientalis, cassia seed, Semen Leonuri, traditional Chinese medicinal components compatibility is reasonable, patient's slight illness can effectively be relieved, had no toxic side effect, instant effect, present invention also offers the preparation method of the granule, method is simple, easily controllable, the present invention is applied to treatment non-alcoholic fatty liver disease.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of Chinese herbal granules for treating non-alcoholic fatty liver disease.
Background technology
Non-alcoholic fatty liver disease（non-alcoholic fatty liver disease, NAFLD）, also known as non-alcohol
Property fatty liver（NAFL）, including simple fatty liver（simple fatty liver, SFL）, nonalcoholic fatty liver disease
（non-alcoholic steatohepatitis, NASH）, non-alcoholic correlation liver fibrosis and its related liver cirrhosis, refer to
Except alcohol and other clearly damage liver factors caused by, the clinic with diffusivity liver cell Macrovesicular steatosis as principal character
Pathological syndrome, the acquired metabolic stress hepatic injury closely related with insulin resistance and genetic predisposition.
The mechanism of non-alcoholic fatty liver disease potentially includes two strikes.First strike is steatosis, second
Individual strike is oxidative stress and peroxidatic reaction of lipid.Mainly include：External fat acid is mobilized and increased, and liver synthetic fatty acid increases
Plus, the function of liver catabolism aliphatic acid is damaged, and liver and is damaged into secretion VLDL ability, gangrenous inflammation
Change.SFL such as active treatments, can recover completely.NASH more than discovery early, active treatment if can recover.Recent years abroad is several
Perspective study to NASH shows that part NASH can develop into cirrhosis, it is taken as that NASH is to be only second to alcohol and virus
Property hepatitis causes the third-largest cause of disease of cirrhosis.
There is no " non-alcoholic fatty liver disease " this name of disease in traditional Chinese medicine, according to its clinical symptoms, numerous scholars are by non-wine
Essence fatty liver hepatopathy belongs to the categories such as " accumulation ", " hypochondriac pain ", " feeling of fullness ", " the phlegm addiction " of the traditional Chinese medical science.Its cardinal symptom is the side of body
Bitterly, swollen, gastral cavity abdomen ruffian is swollen is coerced, lassitude hypodynamia, poor, apocleisis of receiving are greasy, dry mouth with bitter taste, greasy fur on tongue etc..Its cause of disease mainly has diet not
Section, emotional maladjustment, weakness due to chronic disease.《Plain Questions numbness opinion》Say：" eating twice as usual, stomach is wound." overfeeding delicious food, eating and drinking without temperance, spleen
Gastric injury, the dysfunction of the spleen in transport, it is impossible to ascending the clear and descending the turbid, cause raw in phlegm wet；Disorder of emotion, liver dysfunction, then depression and stagnation of QI, three Jiao Shui
Road is obstructed, and aqueous metabolic disorder, phlegm wet is mutually tied and caused in liver；Weakness due to chronic disease, transporting and transforming function of the spleen and stomach is powerless, and water paddy can not change essence, gathers wet
Raw phlegm, phlegm wet resistance network, hematogenous blockage, phlegm and blood stasis are in liver.Its main pathogenesis can be attributed to liver dysfunction, and the dysfunction of the spleen in transport is wet poly-
It is phlegm, the stagnant passages through which vital energy circulates of phlegm, QI-blood circulation is not smooth, causes stagnation of blood stasis liver arteries and veins to form.It is worth mentioning that phlegm, drink, the stasis of blood, heat etc. it is tangible it
Heresy, is the pathological product of all cause of disease interactions, and the visceral-qi function such as liver,spleen,kidney is caused as the new cause of disease again after formation
Power is unequal to heresy, further empty tired, and with the passing of time, vicious circle, stage develops into various critical syndromes such as cirrhosis for delay.
With the improvement of living standards, dietary structure changes and prevention and health care measure relatively lags behind, China's non-alcoholic fat
The fat liver incidence of disease rises year by year, and it has turned into the second largest chronic liver disease for being only second to virus hepatitis.NASH
Sick onset concealment, morbidity is slow, and often asymptomatic, NAFLD is to cause the elevated primary cause of disease of asymptomatic transaminase, it is considered to be
One of common disease factor of cryptogenic cirrhosis.
Recent years abroad research display, part NAFLD can develop into cirrhosis, as causing " the 3rd killer " of cirrhosis,
In terms for the treatment of, the aggregate measures such as many use in conjunction dietary therapies of preventing and treating, exercise therapy, behavior amendment treatment of existing fatty liver,
Cause of disease inducement is wherein removed, actively controls primary basis sick mostly important, the medicine of current clinical practice mainly has pancreas islet
Plain sensitizer, but the Western medicine of routine has certain adverse reaction.
The content of the invention
The technical problems to be solved by the invention are, in order to overcome the deficiencies in the prior art, there is provided one kind treats non-wine
The Chinese herbal granules of essence fatty liver, traditional Chinese medicinal components compatibility rationally, can effectively relieve patient's slight illness, have no toxic side effect, and see
Effect is fast；
Present invention also offers the preparation method of above-mentioned Chinese herbal granules, the method is simple, it is easy to control.
In order to solve the above technical problems, the technical scheme that the present invention is provided is as follows：
A kind of Chinese herbal granules for treating non-alcoholic fatty liver disease, it is characterised in that in parts by weight, it includes as follows
Component：
It is 13 parts of the red sage root, 10 parts of rhizoma alismatis, 15 parts of radix bupleuri, 15 parts of gynostemma pentaphylla, 9 parts of turmeric, 12 parts of raw hawthorn, 10 parts of the vine of multiflower knotweed, bright pink
10 parts of beggar, 15 parts of cassia seed, 15 parts of Semen Leonuri.
The pharmacological effect of each taste medicine is as follows in said components：
The red sage root, rhizoma alismatis：The promoting blood circulation and removing blood stasis, Li Shui that expels the heat-evil is monarch, directs at that NASH basic pathology feature is wet, hot, the stasis of blood；
Radix bupleuri, gynostemma pentaphylla, turmeric：Profit liver and gall are dredged, Qinghua is damp and hot, assist monarch drug in a prescription degraded fat, be altogether ministerial drug；
Raw hawthorn, the vine of multiflower knotweed, fructus polygoni orientalis：Enter Liver Channel altogether, play the effect of lipid-loweringing promoting blood circulation and removing blood stasis, be adjutant；
Cassia seed, Semen Leonuri clear liver, to make medicine.
Above-mentioned all medicines share, plays clearing liver of purging heat, the work(of blood activating and fat reducing altogether.
Present invention also offers the preparation method of the Chinese herbal granules granule of above-mentioned treatment non-alcoholic fatty liver disease,
（1）All of Chinese medicine material adds the decocting of raw material three times weight to boil twice, and 1h is decocted every time, merges decocting liquid twice, filters,
Filtrate is concentrated into relative density and is about 1.08（90-95℃）, room temperature to be cooled to, plus the ethanol of equivalent precipitates it, stands；
（2）Above-mentioned steps supernatant concentration is taken to relative density to 1.20（60-65℃）, plus equivalent water stirring, stand 8h, take
Supernatant concentration is to relative density 1.38-1.40（60-65℃）Clear cream.
（3）2 parts of 1 part of qinghuo reagent, 3 parts of cane sugar powder, 1.25 parts of dextrin and ethanol, are made particle, after drying, obtain final product.
Collaboration effect has been played between the Chinese herbal granules for the treatment of non-alcoholic fatty liver disease provided by the present invention, drug component
Should, the Chinese medicine can effectively relieve patient's slight illness, have no toxic side effect, instant effect, effect is significant.
The present invention is applied to treatment non-alcoholic fatty liver disease.
Specific embodiment
The present invention is further described with reference to specific embodiment.Unless stated otherwise, the present invention use reagent,
Apparatus and method are the art reagent routinely purchased in market, equipment and conventional use of method.
Embodiment 1 is a kind of to treat Chinese herbal granules of non-alcoholic fatty liver disease and preparation method thereof
The present embodiment be a kind of Chinese herbal granules for treating non-alcoholic fatty liver disease it include following components：
Red sage root 13g, the g of rhizoma alismatis 10, the g of radix bupleuri 15, the g of gynostemma pentaphylla 15, the g of turmeric 9, the g of raw hawthorn 12, the g of the vine of multiflower knotweed 10, prince ' s-feather
10 g of son, the g of cassia seed 15, the g of Semen Leonuri 15.
The Chinese herbal granules are prepared according to following preparation method：
（1）All of Chinese medicine material adds the decocting of raw material three times weight to boil twice, and 1h is decocted every time, merges decocting liquid twice, filters,
Filtrate is concentrated into relative density and is about 1.08（90-95℃）, room temperature to be cooled to, plus the ethanol of equivalent precipitates it, stands；
（2）Above-mentioned steps supernatant concentration is taken to relative density to 1.20（60-65℃）, plus equivalent water stirring, stand 8h, take
Supernatant concentration is to relative density 1.38-1.40（60-65℃）Clear cream.
（3）Qinghuo reagent 1g, cane sugar powder 3g, dextrin 1.25g and ethanol 2g, are made particle, after drying, obtain final product.
Instructions of taking：One week is a course for the treatment of, is taken twice within one day, one every time（Above-mentioned gained granule is one）,
After one course for the treatment of, illness has been alleviated, after general three courses for the treatment of, recovery from illness.
The model case of embodiment 2：
（1）, patient poplar, man, 50 years old.
Existing primary symptom：, with gastral cavilty turgor, again and again, mood is impatient, distending pain in the head for belch, receives less, and appetite is not good enough, sleeps for right flank rib secret anguish
Feel unwell, defecate disturbance of defecation with either dry or loose stool, thin white fur of tongue, veins string.Physical examination fat of having a blood test shows：CHOL5.7mmol/L, TG2.01mmol/L, HDL-
C2.16mmol/L.Liver and gall pancreas spleen color ultrasound is shown：Mild fatty liver.
Doctor trained in Western medicine is diagnosed as fatty liver（Slightly）, combined hyperlipidemia familial.
Tcm diagnosis are hypochondriac pain disease Liver depression and Qi stagnation.
After 7 doses of the granule of embodiment 1 of taking medicine, all diseases alleviates, and food of receiving increases, when have headache, Charred Triplet, plus the root of Dahurain angelica are removed in front
Only have a headache, 14 doses of following the service does not tell hypochondriac pain again, and mood is gentle, fat of having a blood test is normal, and liver and gall pancreas spleen color ultrasound is shown：Have no obvious occupancy
Lesion.
（2）, patient when so-and-so, female, 49 years old.
Patient's gastral cavilty turgor, belch is indigestion and loss of appetite, sleeps and feels unwell, difficulty falling asleep, and stool is uncommon half congealed, and indented tongue margin, matter is light, and tongue is thin white,
Arteries and veins is thin and delicate.Doctor trained in Western medicine is diagnosed as hypercholesterolemia.
Tcm diagnosis are stomach ruffian disease, syndrome of deficiency of both heart and spleen.Control with blood-enrich, invigorating spleen and nourishing heart.
7 doses of the granule that embodiment 1 is provided is taken, gasteremphraxis mitigates, receives to sleep and take a turn for the better, and big loose stool is thin, and pink tongue, tongue is thin
In vain, arteries and veins is thin.
5. patient in certain, female, 56 years old.
The right distending pain in hypochondrium of main cause 3 months.Occurs the right distending pain in hypochondrium after patient's temperament and interest is not smooth before March, existing patient's right flank rib is swollen
Bitterly, substantially bitter taste from morning, without heartburn sour regurgitation, receives deficiency of food, and apocleisis is greasy night, night sleep can, stool matter still, day a line.Tongue is red
Yellow,greasy and thin fur, wiry and rolling pulse.Auxiliary examination：Blood fat：CHOL6.1mmol/L, LDL-C5.0mmol/L.Liver and gall pancreas spleen color ultrasound is looked into show：
Moderate fatty liver, gall-bladder muddy stone.
Doctor trained in Western medicine is diagnosed as：Moderate fatty liver hypercholesterolemia gall stone（Silt sample）.
Tcm diagnosis are：Hypochondriac pain disease liver and gallbladder damp-heat.Control with dispersing stagnated hepatoqi, disappear esterified stone.Side's bupleurum powder for relieving liver-qi is puted the palms together before one taste
Lipid-regulating grain is added and subtracted.
After taking 14 doses of the medicine that the present embodiment 1 is provided, patient's right flank distending pain mitigates, and occasionally has bitter taste, receives improvement, and night sleeps peace,
Stool matter can.Red tongue with thin fur yellow greasy, veins is sliding.
Above-described embodiment, is only presently preferred embodiments of the present invention, is not other forms made for the present invention
Limit, any those skilled in the art are changed as enlightenment possibly also with above-mentioned technology contents or are modified as equivalent
The Equivalent embodiments of change.In every case it is the technical spirit without departing from the claims in the present invention, to the letter done by above example
Single modification, equivalent variations and remodeling, still fall within the scope of the claims in the present invention protection.
Claims (2)
1. a kind of Chinese herbal granules for treating non-alcoholic fatty liver disease, it is characterised in that in parts by weight, it is included such as
Lower component：
It is 13 parts of the red sage root, 10 parts of rhizoma alismatis, 15 parts of radix bupleuri, 15 parts of gynostemma pentaphylla, 9 parts of turmeric, 12 parts of raw hawthorn, 10 parts of the vine of multiflower knotweed, bright pink
10 parts of beggar, 15 parts of cassia seed, 15 parts of Semen Leonuri.
2. the preparation method of the Chinese herbal granules for the treatment of non-alcoholic fatty liver disease according to claim 1, its feature exists
Carried out successively according to steps order in it：
（1）All of Chinese medicine material adds the decocting of raw material three times weight to boil twice, and 1h is decocted every time, merges decocting liquid twice, filters,
Filtrate is concentrated into relative density and is about 1.08, and room temperature to be cooled to, plus the ethanol of equivalent precipitates it, stands；
（2）Above-mentioned steps supernatant concentration is taken to relative density to 1.20, plus equivalent water stirring, stand 8h, take supernatant dense
It is reduced to the clear cream of relative density 1.38-1.40；
（3）2 parts of 1 part of qinghuo reagent, 3 parts of cane sugar powder, 1.25 parts of dextrin and ethanol, are made particle, after drying, obtain final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116370592A (en) * | 2023-02-20 | 2023-07-04 | 黑龙江省中医药科学院 | Traditional Chinese medicine composition for treating non-alcoholic fatty liver fibrosis as well as preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1520833A (en) * | 2003-01-28 | 2004-08-18 | 王淑月 | Composition for alcohol type fatty liver |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1520833A (en) * | 2003-01-28 | 2004-08-18 | 王淑月 | Composition for alcohol type fatty liver |
| CN1246020C (en) * | 2003-01-28 | 2006-03-22 | 王淑月 | Composition for alcohol type fatty liver |
Non-Patent Citations (1)
| Title |
|---|
| 张娜: "十味调脂方对非酒精性脂肪肝病大鼠SREBP-1c mRNA表达的实验研究", 《万方数据》 * |
Cited By (1)
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|---|---|---|---|---|
| CN116370592A (en) * | 2023-02-20 | 2023-07-04 | 黑龙江省中医药科学院 | Traditional Chinese medicine composition for treating non-alcoholic fatty liver fibrosis as well as preparation method and application thereof |
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Application publication date: 20170613 |