CN109692309B - Traditional Chinese medicine for treating non-alcoholic fatty liver disease, eliminating dampness and activating blood - Google Patents

Traditional Chinese medicine for treating non-alcoholic fatty liver disease, eliminating dampness and activating blood Download PDF

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CN109692309B
CN109692309B CN201910189173.5A CN201910189173A CN109692309B CN 109692309 B CN109692309 B CN 109692309B CN 201910189173 A CN201910189173 A CN 201910189173A CN 109692309 B CN109692309 B CN 109692309B
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liver
fatty liver
blood
dampness
rhizoma
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CN109692309A (en
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刘旭东
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RUIKANG HOSPITAL AFFILIATED TO GUANGXI UNIVERSITY OF CHINESE MEDICINE
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RUIKANG HOSPITAL AFFILIATED TO GUANGXI UNIVERSITY OF CHINESE MEDICINE
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention belongs to the field of medicine processing, and particularly relates to a dampness-eliminating and blood-activating formula for treating non-alcoholic fatty liver disease, which mainly adopts lotus leaves, poria cocos, rhizoma atractylodis macrocephalae, semen cassiae, semen coicis, rhizoma alismatis, polyporus umbellatus, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidatum, herba artemisiae scopariae, astragalus mongholicus, liquorice, dried orange peel, radix bupleuri, radix paeoniae rubra, rhizoma zedoariae, salvia miltiorrhiza and wine rheum officinale as main components of the dampness-eliminating and blood-activating formula for treating non; cassia seed, coix seed and alisma orientale liver-soothing to eliminate dampness and activate blood. The prescription takes dampness elimination and blood circulation promotion as main lines, and is assisted by products for soothing the liver and clearing heat, so as to relax the liver and collaterals and clear away stagnated heat. The traditional Chinese medicine has the effects of calming the liver, tonifying the spleen, promoting diuresis, reducing phlegm, removing stagnation, activating blood, regulating blood fat and promoting liver cell repair, has a good effect of treating the non-alcoholic fatty liver and has no toxic or side effect.

Description

Traditional Chinese medicine for treating non-alcoholic fatty liver disease, eliminating dampness and activating blood
[ technical field ] A method for producing a semiconductor device
The invention belongs to the field of medicine processing, and particularly relates to a dampness-eliminating and blood-activating traditional Chinese medicine for treating non-alcoholic fatty liver.
[ background of the invention ]
Non-alcoholic fatty liver disease (NAFLD) refers to the clinical pathological syndrome characterized mainly by excessive fat deposition in liver cells due to the exclusion of alcohol and other definite liver damage factors, and acquired metabolic stress liver damage closely related to insulin resistance and genetic susceptibility. Including Simple Fatty Liver (SFL), non-alcoholic steatohepatitis (NASH) and its associated cirrhosis. With the global epidemic trend of obesity and related metabolic syndrome, the nonalcoholic fatty liver disease becomes an important cause of chronic liver disease in developed countries such as Europe and America and affluent areas of China, the prevalence rate of NAFLD of common adults is 10% -30%, wherein 10% -20% of NASH is NASH, and the incidence rate of cirrhosis of liver in 10 years of NASH is up to 25%.
Non-alcoholic fatty liver disease can directly cause decompensated liver cirrhosis, hepatocellular carcinoma and relapse of transplanted liver, can affect the progress of other chronic liver diseases, and is involved in the onset of type 2 diabetes and atherosclerosis. Malignant tumors related to metabolic syndrome, arteriosclerotic cardiovascular and cerebrovascular diseases and liver cirrhosis are important factors influencing the quality of life and the life expectancy of non-alcoholic fatty liver patients. For this reason, non-alcoholic fatty liver disease is a new challenge in the contemporary medical field, and the harm of non-alcoholic fatty liver disease to human health will continue to increase in the near future.
Non-alcoholic fatty liver disease with abnormal liver function, metabolic syndrome, still ineffective after 3-6 months of basic treatment, and liver biopsy prove that NASH and the course of disease are chronic progressive passers, can adopt the drug-assisted treatment aiming at liver disease, uses oxidation resistance, anti-inflammation and anti-fibrosis, can reasonably select related drugs such as polyene phosphatidylcholine, vitamin E, silymarin, ursodeoxycholic acid and the like according to the drug performance, the disease activity and the disease period, but can not radically cure and has side effects.
[ summary of the invention ]
In view of the problems, the invention provides the traditional Chinese medicine for treating nonalcoholic fatty liver, which is prepared from a plurality of traditional Chinese medicines, can effectively and radically treat nonalcoholic fatty liver, and is free of toxic and side effects.
The technical problem to be solved by the invention is realized by adopting the following technical scheme:
a traditional Chinese medicine for treating non-alcoholic fatty liver disease, which has the effects of eliminating dampness and promoting blood circulation, mainly comprises the following raw materials: lotus leaf, tuckahoe, atractylodes, cassia seed, coix seed, alisma orientale, umbellate pore fungus, gynostemma pentaphylla, pinellia tuber, giant knotweed rhizome, oriental wormwood, astragalus root, licorice, tangerine peel, bupleurum root, red peony root, zedoary, red sage and rhubarb.
Preferably, the dampness-eliminating and blood-activating traditional Chinese medicine for treating the non-alcoholic fatty liver comprises the following materials by weight: 5-20 g of lotus leaf, 12-30 g of poria cocos, 10-20 g of bighead atractylodes rhizome, 20-30 g of cassia seed, 25-35 g of coix seed, 10-20 g of rhizoma alismatis, 5-15 g of polyporus umbellatus, 5-25 g of gynostemma pentaphylla, 10-15 g of rhizoma pinellinae praeparata, 10-18 g of polygonum cuspidatum, 11-16 g of oriental wormwood, 15-30 g of astragalus membranaceus, 5-10 g of liquorice, 6-13 g of dried orange peel, 10-16 g of radix bupleuri, 10-17 g of red peony root, 8-19 g of curcuma zedoary, 11-17 g of salvia miltiorrhiza and 7-20 g.
Preferably, the dampness-eliminating and blood-activating traditional Chinese medicine for treating the non-alcoholic fatty liver disease is mainly prepared from the following materials in parts by weight: the damp-clearing and blood-activating formula for treating the non-alcoholic fatty liver disease also comprises the following materials by weight: 5g of lotus leaf, 12g of tuckahoe, 10g of atractylodes macrocephala, 20g of cassia seed, 25g of coix seed, 10g of rhizoma alismatis, 5g of polyporus, 5g of gynostemma pentaphylla, 10g of rhizoma pinellinae praeparata, 10g of giant knotweed, 11g of oriental wormwood, 15g of astragalus, 5g of liquorice, 6g of dried orange peel, 10g of radix bupleuri, 10g of red peony root, 8g of curcuma zedoary, 11g of salvia miltiorrhiza and 7g of rhubarb with wine.
Preferably, the traditional Chinese medicine for treating the non-alcoholic fatty liver disease, eliminating dampness and activating blood circulation also comprises the following materials by weight: 17g of lotus leaf, 18g of poria cocos, 16g of bighead atractylodes rhizome, 27g of cassia seed, 29g of coix seed, 19g of rhizoma alismatis, 14g of polyporus umbellatus, 21g of gynostemma pentaphylla, 13g of rhizoma pinellinae praeparata, 16g of polygonum cuspidatum, 12g of oriental wormwood, 18g of astragalus membranaceus, 9g of liquorice, 11g of dried orange peel, 13g of radix bupleuri, 14g of red peony root, 17g of curcuma zedoary, 15g of salvia miltiorrhiza and 17 g.
Preferably, the traditional Chinese medicine for treating the non-alcoholic fatty liver disease, eliminating dampness and activating blood circulation also comprises the following materials by weight: 20g of lotus leaf, 30g of poria cocos, 20g of bighead atractylodes rhizome, 30g of cassia seed, 35g of coix seed, 20g of rhizoma alismatis, 15g of polyporus umbellatus, 25g of gynostemma pentaphylla, 15g of rhizoma pinellinae praeparata, 18g of polygonum cuspidatum, 16g of oriental wormwood, 30g of astragalus membranaceus, 10g of liquorice, 13g of dried orange peel, 16g of radix bupleuri, 17g of red paeony root, 19g of curcuma zedoary, 17g of salvia miltiorrhiza and 20.
The preparation method of the damp-clearing and blood-activating formula for treating the non-alcoholic fatty liver disease comprises the following steps:
1) selecting lotus leaves, poria cocos, bighead atractylodes rhizome, cassia seeds, coix seeds, rhizoma alismatis, grifola, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidatum, oriental wormwood and astragalus mongholicus, crushing to obtain powder, adding the powder into water, mixing, putting into a pot, decocting with strong fire for 5-10 minutes, and then decocting with slow fire;
2) putting areca-nut liquorice, dried orange peel, radix bupleuri, red paeony root and curcuma zedoary into a marmite, continuously decocting with slow fire until the mixture is boiled, after the mixture is boiled, continuously decocting with slow fire for 15-30 minutes, adding the salvia miltiorrhiza and the wine rhubarb, decocting with slow fire for half an hour, cooling the liquid medicine, and filtering to obtain the liquid medicine;
3) concentrating the liquid medicine obtained in the step 2), then preparing into granules, and drying and dehydrating to obtain the dampness-eliminating and blood-activating formula for treating the non-alcoholic fatty liver.
Hu Zhang enters liver and spleen meridians and has the action of protecting liver.
Atractylodis rhizoma can prevent and treat liver injury caused by carbon tetrachloride, relieve hepatic glycogen decrease and hepatic cell degeneration necrosis, promote hepatocyte growth, and reduce ALT.
Polyporus umbellatus is sweet and bland in taste, neutral in nature, and capable of excreting dampness and promoting urination. Research shows that polyporus polysaccharide contained in polyporus umbellatus has the functions of increasing liver glycogen accumulation and promoting liver cell regeneration. Polyporus can improve phagocytic activity of cells, promote cellular immunity, and promote the production of hepatitis surface antibody.
The Saviae Miltiorrhizae radix has effects of improving liver microcirculation, inhibiting antibody formation, scavenging oxygen free radicals, improving liver function, reducing transaminase, eliminating jaundice, and promoting liver cell regeneration.
Bupleurum root, radix bupleuri, entering liver and gallbladder meridians, has the actions of soothing liver and relieving depression. Modern pharmacological research also shows that the bupleurum has the functions of resisting hepatitis virus, promoting immunity and protecting liver. The liver protection tablet taking the bupleurum as the main component is also mainly used for reducing transaminase, restoring liver function and reducing liver injury clinically.
The lotus leaf has the functions of protecting liver cells, promoting liver cell regeneration, removing fat and inhibiting liver cell fibrosis, and can resist liver toxicity. Curcumin and volatile oil can promote bile secretion and excretion, and reduce bird gall bladder in urine; the decoction can stimulate gastric acid and duodenal juice to be secreted one by one. The water decoction can reduce whole blood viscosity, inhibit platelet aggregation, and the alcohol extract can reduce plasma fibrin content.
Alismatis rhizoma has antibacterial effect, can inhibit regeneration of gastrointestinal bacteria, and reproduction of liver virus, and has effects of relieving inflammation and protecting liver.
Gynostemma pentaphylla is good at entering liver, removing food retention, resolving hard mass, breaking qi in blood, relieving the adverse side effects of injury, eliminating symptoms and weakness of internal diseases.
Fa ban Xia enters liver and lung meridians. The functions are mainly used for invigorating yang, relieving exterior syndrome, promoting eruption and detoxifying.
Herba Artemisiae Scopariae can promote gastrointestinal peristalsis; anti-ulcer; benefiting gallbladder; relaxing tracheal smooth muscle; has sex hormone-like effect; central paralysis; bacteriostasis; and (3) resisting tumors. The decoction can excite the in vitro rabbit intestine to shrink and promote the in vivo rabbit intestine to peristalsis, the fennel oil and the anethole firstly excite the intestinal canal to strengthen the shrinkage, and the concentration is increased to have spasmolysis; the product can be administered by drenching or by duodenal administration to animals for inhibiting stress gastric ulcer; for rats with partial hepatectomy, the anise oil can increase the liver regeneration degree; the propanol extract has effects of sex hormone-like; in addition, it also has effects of inhibiting central nervous system, resisting coagulation, and resisting fibrinolysis.
Due to the adoption of the technical scheme, the invention has the following beneficial effects: lotus leaf, tuckahoe, atractylodes, cassia seed, coix seed, alisma orientale, polyporus, gynostemma pentaphylla, rhizoma pinellinae praeparata, giant knotweed, oriental wormwood, astragalus, liquorice, dried orange peel, radix bupleuri, red peony root, zedoary, salvia miltiorrhiza and wine rhubarb are mainly used as main components of the prescription for treating nonalcoholic fatty liver, eliminating dampness and activating blood, and the lotus leaf, the tuckahoe and the atractylodes are used for strengthening spleen and eliminating dampness; cassia seed, coix seed and alisma orientale liver-soothing to eliminate dampness and activate blood. The prescription takes dampness elimination and blood circulation promotion as main lines, and is assisted by products for soothing the liver and clearing heat, so as to relax the liver and collaterals and clear away stagnated heat. The traditional Chinese medicine has the effects of calming the liver, tonifying the spleen, promoting diuresis, reducing phlegm, removing stagnation, activating blood, regulating blood fat and promoting liver cell repair, has a good effect of treating the non-alcoholic fatty liver and has no toxic or side effect.
[ detailed description ] embodiments
The following examples may help one skilled in the art to more fully understand the present invention, but are not intended to limit the invention in any way.
Example 1
The traditional Chinese medicine for treating the non-alcoholic fatty liver disease, eliminating dampness and activating blood circulation is mainly prepared from the following materials by weight: 5g of lotus leaf, 12g of tuckahoe, 10g of atractylodes macrocephala, 20g of cassia seed, 25g of coix seed, 10g of rhizoma alismatis, 5g of polyporus, 5g of gynostemma pentaphylla, 10g of rhizoma pinellinae praeparata, 10g of giant knotweed, 11g of oriental wormwood, 15g of astragalus, 5g of liquorice, 6g of dried orange peel, 10g of radix bupleuri, 10g of red peony root, 8g of curcuma zedoary, 11g of salvia miltiorrhiza and 7g of rhubarb with wine.
The preparation method of the traditional Chinese medicine for treating the non-alcoholic fatty liver disease, which has the functions of eliminating dampness and promoting blood circulation, comprises the following steps:
1) selecting lotus leaves, poria cocos, bighead atractylodes rhizome, cassia seeds, coix seeds, rhizoma alismatis, grifola, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidatum, oriental wormwood and astragalus mongholicus, crushing to obtain powder, adding the powder into water, mixing, putting into a pot, decocting with strong fire for 5-10 minutes, and then decocting with slow fire;
2) putting areca-nut liquorice, dried orange peel, radix bupleuri, red paeony root and curcuma zedoary into a marmite, continuously decocting with slow fire until the mixture is boiled, after the mixture is boiled, continuously decocting with slow fire for 15-30 minutes, adding the salvia miltiorrhiza and the wine rhubarb, decocting with slow fire for half an hour, cooling the liquid medicine, and filtering to obtain the liquid medicine;
3) concentrating the liquid medicine obtained in the step 2), then preparing into granules, and drying and dehydrating to obtain the dampness-eliminating and blood-activating formula for treating the non-alcoholic fatty liver.
Example 2
The traditional Chinese medicine for treating the non-alcoholic fatty liver disease, eliminating dampness and activating blood circulation is mainly prepared from the following materials by weight: 17g of lotus leaf, 18g of poria cocos, 16g of bighead atractylodes rhizome, 27g of cassia seed, 29g of coix seed, 19g of rhizoma alismatis, 14g of polyporus umbellatus, 21g of gynostemma pentaphylla, 13g of rhizoma pinellinae praeparata, 16g of polygonum cuspidatum, 12g of oriental wormwood, 18g of astragalus membranaceus, 9g of liquorice, 11g of dried orange peel, 13g of radix bupleuri, 14g of red peony root, 17g of curcuma zedoary, 15g of salvia miltiorrhiza and 17 g.
The preparation method of the traditional Chinese medicine for treating the non-alcoholic fatty liver disease, which has the functions of eliminating dampness and promoting blood circulation, comprises the following steps:
1) selecting lotus leaves, poria cocos, bighead atractylodes rhizome, cassia seeds, coix seeds, rhizoma alismatis, grifola, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidatum, oriental wormwood and astragalus mongholicus, crushing to obtain powder, adding the powder into water, mixing, putting into a pot, decocting with strong fire for 5-10 minutes, and then decocting with slow fire;
2) putting areca-nut liquorice, dried orange peel, radix bupleuri, red paeony root and curcuma zedoary into a marmite, continuously decocting with slow fire until the mixture is boiled, after the mixture is boiled, continuously decocting with slow fire for 15-30 minutes, adding the salvia miltiorrhiza and the wine rhubarb, decocting with slow fire for half an hour, cooling the liquid medicine, and filtering to obtain the liquid medicine;
3) concentrating the liquid medicine obtained in the step 2), then preparing into granules, and drying and dehydrating to obtain the dampness-eliminating and blood-activating formula for treating the non-alcoholic fatty liver.
Example 3
The traditional Chinese medicine for treating the non-alcoholic fatty liver disease, eliminating dampness and activating blood circulation is mainly prepared from the following materials by weight: 20g of lotus leaf, 30g of poria cocos, 20g of bighead atractylodes rhizome, 30g of cassia seed, 35g of coix seed, 20g of rhizoma alismatis, 15g of polyporus umbellatus, 25g of gynostemma pentaphylla, 15g of rhizoma pinellinae praeparata, 18g of polygonum cuspidatum, 16g of oriental wormwood, 30g of astragalus membranaceus, 10g of liquorice, 13g of dried orange peel, 16g of radix bupleuri, 17g of red paeony root, 19g of curcuma zedoary, 17g of salvia miltiorrhiza and 20.
The preparation method of the traditional Chinese medicine for treating the non-alcoholic fatty liver disease, which has the functions of eliminating dampness and promoting blood circulation, comprises the following steps:
1) selecting lotus leaves, poria cocos, bighead atractylodes rhizome, cassia seeds, coix seeds, rhizoma alismatis, grifola, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidatum, oriental wormwood and astragalus mongholicus, crushing to obtain powder, adding the powder into water, mixing, putting into a pot, decocting with strong fire for 5-10 minutes, and then decocting with slow fire;
2) putting areca-nut liquorice, dried orange peel, radix bupleuri, red paeony root and curcuma zedoary into a marmite, continuously decocting with slow fire until the mixture is boiled, after the mixture is boiled, continuously decocting with slow fire for 15-30 minutes, adding the salvia miltiorrhiza and the wine rhubarb, decocting with slow fire for half an hour, cooling the liquid medicine, and filtering to obtain the liquid medicine;
3) concentrating the liquid medicine obtained in the step 2), then preparing into granules, and drying and dehydrating to obtain the dampness-eliminating and blood-activating formula for treating the non-alcoholic fatty liver.
Example 4
The traditional Chinese medicine for treating the non-alcoholic fatty liver disease, eliminating dampness and activating blood circulation is mainly prepared from the following materials: lotus leaf, tuckahoe, atractylodes, cassia seed, coix seed, alisma orientale, umbellate pore fungus, gynostemma pentaphylla, pinellia tuber, giant knotweed rhizome, oriental wormwood, astragalus root, licorice, tangerine peel, bupleurum root, red peony root, zedoary, red sage and rhubarb.
The preparation method of the traditional Chinese medicine for treating the non-alcoholic fatty liver disease, which has the functions of eliminating dampness and promoting blood circulation, comprises the following steps:
1) selecting lotus leaves, poria cocos, bighead atractylodes rhizome, cassia seeds, coix seeds, rhizoma alismatis, grifola, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidatum, oriental wormwood and astragalus mongholicus, crushing to obtain powder, adding the powder into water, mixing, putting into a pot, decocting with strong fire for 5-10 minutes, and then decocting with slow fire;
2) putting areca-nut liquorice, dried orange peel, radix bupleuri, red paeony root and curcuma zedoary into a marmite, continuously decocting with slow fire until the mixture is boiled, after the mixture is boiled, continuously decocting with slow fire for 15-30 minutes, adding the salvia miltiorrhiza and the wine rhubarb, decocting with slow fire for half an hour, cooling the liquid medicine, and filtering to obtain the liquid medicine;
3) concentrating the liquid medicine obtained in the step 2), then preparing into granules, and drying and dehydrating to obtain the dampness-eliminating and blood-activating formula for treating the non-alcoholic fatty liver.
Examples of the experiments
140 patients who are admitted in the hepatology department of the hospital and meet the admission standard are randomly selected, coded according to the hospital order and randomly divided into A, B, C, D, E, F, G7 groups. The group A is treated by the formula for treating the non-alcoholic fatty liver disease, which is prepared in the example 1 and is used for dispelling dampness and activating blood circulation; the group B adopts the formula for treating the non-alcoholic fatty liver disease, which is prepared in the example 2 and is used for eliminating dampness and activating blood; group C was treated with the dampness-eliminating and blood-activating formula for treating non-alcoholic fatty liver disease prepared in example 3; group D is treated by the dampness-eliminating and blood-activating formula for treating the non-alcoholic fatty liver disease, which is prepared by removing lotus leaves, poria cocos, bighead atractylodes rhizome, cassia seeds, coix seeds, rhizoma alismatis and grifola in example 1; group E is treated by the traditional Chinese medicine for treating the nonalcoholic fatty liver, eliminating dampness and activating blood circulation, which is prepared by removing gynostemma pentaphylla, rhizoma pinelliae praeparata, polygonum cuspidatum, oriental wormwood, astragalus mongholicus, liquorice, pericarpium citri reticulatae, radix bupleuri, radix paeoniae rubra, curcuma zedoary, salvia miltiorrhiza and rhubarb wine in example 1; group G adopts polyene phosphatidyl choline capsule (Cenofeirantan Beijing pharmaceuticals, Inc., Chinese medicine standard H20059010, 228 mg/capsule), 2 capsules/time, 3 times/day for treatment; the 7 groups of patients were comparable in age, sex, etiology, course of disease, etc. The other six groups are administered 1 time per day, and the seven groups of treatment course are 30 days as 1 treatment course. The patient's alanine Aminotransferase (ALT), aspartate Aminotransferase (AST), Total Cholesterol (TC), Triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) before and after treatment were measured and compared with each other.
Observing the hepatic fibrosis index change before and after treatment
Figure GDA0003099744660000061
Figure GDA0003099744660000071
TABLE 1 Effect of treatment regimens in each group on non-alcoholic fatty liver disease
As can be seen from Table 1, after 1 treatment course, the ALT/U.L.L-1, TC/mmol.L-1, TG/mmol.L-1, LDL-C/mmol.L-1 contents of A, B, C patients were significantly reduced, which was significantly different from those of the other four groups. The dampness-eliminating and blood-activating formula for treating the non-alcoholic fatty liver disease is proved to have the synergistic effects of reducing fat, protecting the liver and reducing toxicity, has an obvious efficacy of resisting the non-alcoholic fatty liver disease and can obviously improve the indexes of the non-alcoholic fatty liver disease. And the dampness-eliminating and blood-activating formula for treating the non-alcoholic fatty liver disease has the advantages of quick response, high safety, simple and easy technical operation, rich medicine sources, wide application range and the like, and is suitable for popularization and application. And the absence of any one or more of these drugs can greatly reduce the therapeutic efficacy.
The obesity degree is in positive correlation with the incidence of fatty liver, and insulin sensitivity in an obese person is reduced, so that liver fat metabolism disorder is caused, and further, blood fat is increased, and liver cells are damaged.
The pathogenesis of the disease is liver heat and spleen deficiency, phlegm dampness and blood stasis. The location of the disease is mainly in the liver, and it is recorded in ancient and modern medical records that hypochondriac pain or phlegm, which accumulates and flows into the blood, is the disease when it is struggled with the blood; the book of changes states that the accumulation of liver is named as fat and gas; in Ling Jia (a coffin), it is recorded that the pathogenic factors in the liver, pain in the hypochondrium, congestion and blood in the hypochondrium. The local famous medicine Wangjunoquine four-diagnosis combined ginseng is combined with the dietary habits of modern people, and the NAFLD is considered to be mainly caused by the damp-heat stasis of liver channels, the modern people have great working and living pressure to cause the stagnation of liver qi, long-time stasis and heat transformation, and also has the advantages of addiction to fat, sweet, thick and greasy food and hypokinesia to cause spleen deficiency and excessive dampness, disorder of middle-jiao qi activity, dampness and heat accumulation, stagnation in liver channels, obstruction of channels and collaterals into blood stasis, and liver blood collection to generate NAFLD, so the treatment is realized by clearing liver and eliminating dampness, promoting blood circulation and removing obstruction in channels and collaterals, and the non-alcoholic fatty liver dampness eliminating and blood activating formula is self-.
In the formula, the giant knotweed rhizome has the effects of clearing liver and cooling blood, the rhubarb wine has the effects of clearing away liver heat and damp-heat in liver and gallbladder, and the lotus leaf has the effects of soothing liver and activating blood circulation, and are monarch drugs; rhizoma alismatis and grifola umbellata help polygonum cuspidatum to clear liver and cool blood, herba artemisiae scopariae helps sedum sarmentosum to clear liver and gall damp-heat, and radix salviae miltiorrhizae helps lotus leaves to cool blood and activate blood, and nourish heart and soothe nerves, and are used as ministerial drugs together; fennel, cynanchum atratum, scandent hop and corydalis tuber are used as adjuvant drugs for warming the middle-jiao to dispel cold, eliminating dampness and phlegm, preventing cold and cooling stomach. The medicines are combined to play the effects of clearing away damp-heat in liver and gallbladder, promoting blood circulation to remove blood stasis and dissipating stagnation, warming middle energizer to eliminate dampness and reducing phlegm. Modern pharmacological research shows that the giant knotweed contains triterpenes, sterols and other components, has the effects of reducing blood pressure, blood fat and blood sugar, resisting oxidation, resisting free radicals and the like, and the selfheal also has the function of regulating endocrine; herba Sedi has effects of protecting liver and regulating immunity; the folium Nelumbinis has antioxidant, antiinflammatory, and platelet aggregation inhibiting effects.
The clinical treatment of the formula shows obvious advantages. According to previous clinical research, the prescription for treating the non-alcoholic fatty liver by eliminating dampness and activating blood circulation is used for treating the non-alcoholic fatty liver, and a diet exercise control group is used as a control, so that the prescription can obviously reduce the serum glycerol triacetate level of a patient with the non-alcoholic fatty liver and reduce the liver fat deposition degree of the patient.
Typical cases
Mr. alba, 43 years old. The patient was admitted with "fatty liver found by physical examination for more than 2 years and liver function abnormal for 1 week". More than two years ago, the patients find that the fatty liver and the serum triglyceride are slightly increased during physical examination, have no special discomfort and are not paid attention and further diagnosed and treated. Before 1 week, the patients still showed fatty liver when they were again physically examined, with elevated serum transaminase, dyslipidemia and elevated blood uric acid without discomfort. The physician needs to see the physician in this hospital for clear diagnosis and treatment. In the onset of the disease, the patients have normal spirit, stomach and sleep, and defecate and urinate normally. Adopts a prescription for treating the non-alcoholic fatty liver disease by eliminating dampness and activating blood. After a treatment course, the disease condition of a patient is greatly improved, after 3 months, the body weight of the patient is measured again to be 71.1kg, the abdominal circumference is 90cm, and the rechecking biochemical indexes are basically normal; after 6 months, the body weight is measured again to be 67.8kg, the abdominal circumference is 86cm, the biochemical indexes are normal, and the abdominal B-ultrasonic is not obviously abnormal.
Huang, woman, 67 years old disease, history: before 3 months, no obvious inducement appears, and no weakness or anorexia appears at first; the symptoms of hypodynamia, anorexia, no yellow body and eye stain, no nausea, vomiting, no abdominal distension, abdominal pain, diarrhea, no hematemesis, dark stool and no subcutaneous ecchymosis and petechia appear before 1 month; before 4 days, symptoms such as hypodynamia, anorexia and the like are further aggravated, and blood examination in hospitals shows ALT 180U/L, AST 140U/L, TBIL25.57U/L, DBIL7.94U/L and IDBIL17.63U/L, and HBsAg (basic) in two pairs of hepatitis B and B ultrasonic indicates 'fatty liver III degree'; the prescription for treating the non-alcoholic fatty liver by eliminating dampness and activating blood is adopted for treatment; after two courses of treatment, the patient's condition is greatly improved. After the hospital reexamination, the liver function is normal, the GGT is obviously reduced, and the fatty liver disappears.
The preliminary diagnosis of 41-year-old male 5-month-13-year-old man 41-year-old man 5-month-13-year-old man, the patients find fatty liver and other diseases before 4 years of physical examination, and are not systematically treated, the height of the patients is 1.75 meters at present, the weight of the patients is 95 kilograms, the patients are obese, the blood pressure of the patients is 158/100mmHg, the liver function is abnormal, the color ultrasonography examination finds that the patients are moderate fatty liver, and the treatment is carried out by adopting a dampness-eliminating blood-; after a treatment course, the weight is reduced by 12 kg, the blood pressure is reduced to 130/90mmHg, the color Doppler ultrasound shows that the fatty liver disappears and the liver function is normal
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims (4)

1. The traditional Chinese medicine for treating the non-alcoholic fatty liver disease, which is used for clearing damp and activating blood circulation, is characterized by being prepared from the following materials by weight: 5-20 g of lotus leaf, 12-30 g of poria cocos, 10-20 g of bighead atractylodes rhizome, 20-30 g of cassia seed, 25-35 g of coix seed, 10-20 g of rhizoma alismatis, 5-15 g of polyporus umbellatus, 5-25 g of gynostemma pentaphylla, 10-15 g of rhizoma pinellinae praeparata, 10-18 g of polygonum cuspidatum, 11-16 g of oriental wormwood, 15-30 g of astragalus membranaceus, 5-10 g of liquorice, 6-13 g of dried orange peel, 10-16 g of radix bupleuri, 10-17 g of red peony root, 8-19 g of curcuma zedoary, 11-17 g of salvia miltiorrhiza and 7-20 g.
2. The traditional Chinese medicine for treating nonalcoholic fatty liver disease, dispelling dampness and promoting blood circulation according to claim 1, which is prepared from the following materials in parts by weight: 5g of lotus leaf, 12g of tuckahoe, 10g of atractylodes macrocephala, 20g of cassia seed, 25g of coix seed, 10g of rhizoma alismatis, 5g of polyporus, 5g of gynostemma pentaphylla, 10g of rhizoma pinellinae praeparata, 10g of giant knotweed, 11g of oriental wormwood, 15g of astragalus, 5g of liquorice, 6g of dried orange peel, 10g of radix bupleuri, 10g of red peony root, 8g of curcuma zedoary, 11g of salvia miltiorrhiza and 7g of rhubarb with wine.
3. The traditional Chinese medicine for treating nonalcoholic fatty liver disease, dispelling dampness and promoting blood circulation according to claim 1, which is prepared from the following materials in parts by weight: 17g of lotus leaf, 18g of poria cocos, 16g of bighead atractylodes rhizome, 27g of cassia seed, 29g of coix seed, 19g of rhizoma alismatis, 14g of polyporus umbellatus, 21g of gynostemma pentaphylla, 13g of rhizoma pinellinae praeparata, 16g of polygonum cuspidatum, 12g of oriental wormwood, 18g of astragalus membranaceus, 9g of liquorice, 11g of dried orange peel, 13g of radix bupleuri, 14g of red peony root, 17g of curcuma zedoary, 15g of salvia miltiorrhiza and 17 g.
4. The traditional Chinese medicine for treating nonalcoholic fatty liver disease, dispelling dampness and promoting blood circulation according to claim 1, which is prepared from the following materials in parts by weight: 20g of lotus leaf, 30g of poria cocos, 20g of bighead atractylodes rhizome, 30g of cassia seed, 35g of coix seed, 20g of rhizoma alismatis, 15g of polyporus umbellatus, 25g of gynostemma pentaphylla, 15g of rhizoma pinellinae praeparata, 18g of polygonum cuspidatum, 16g of oriental wormwood, 30g of astragalus membranaceus, 10g of liquorice, 13g of dried orange peel, 16g of radix bupleuri, 17g of red paeony root, 19g of curcuma zedoary, 17g of salvia miltiorrhiza and 20.
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