CN109692309A - Treat nonalcoholic fatty liver eliminating toxic dampness and heat side - Google Patents
Treat nonalcoholic fatty liver eliminating toxic dampness and heat side Download PDFInfo
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Abstract
The invention belongs to drug manufacture fields, more particularly to treatment nonalcoholic fatty liver eliminating toxic dampness and heat side, the main main component using lotus leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae, cassia seed, semen coicis, rhizoma alismatis, umbellate pore furgus, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidate, oriental wormwood, Radix Astragali, Radix Glycyrrhizae, dried orange peel, radix bupleuri, radix paeoniae rubra, curcuma zedoary, Radix Salviae Miltiorrhizae, Rheum palmatum (processed with wine) as treatment nonalcoholic fatty liver eliminating toxic dampness and heat side, lotus leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae invigorating the spleen excreting dampness；Cassia seed, semen coicis, rhizoma alismatis are soothing the liver in favor of eliminating toxic dampness and heat.Prescription is served as theme with eliminating toxic dampness and heat, is helped with soothing the liver, heat-clearing product, happy liver network, removing summer-heat is hot and suffocating.The calming the liver invigorating the spleen, dampness removing resolving sputum, promoting promoting blood circulation have adjustment blood lipid, promote the function of liver cell reparation, and treatment nonalcoholic fatty liver effect is good, has no toxic side effect.
Description
[technical field]
The invention belongs to drug manufacture fields, and in particular to treatment nonalcoholic fatty liver eliminating toxic dampness and heat side.
[background technique]
Alcohol and liver cell caused by other specific damage liver factors except non-alcohol fatty liver (NAFLD) refers to
Interior fat over-deposit is the clinical pathology syndrome of main feature, and insulin resistance and genetic predisposition are closely related obtains
Obtain property metabolic stress hepatic injury.Including simple fatty liver (SFL), nonalcoholic fatty liver disease (NASH) and its related liver
Hardening.With the fashion trend of fat and its associated metabolic syndrome globalization, non-alcohol fatty liver has become Europe
The Important cause of disease of Mei Deng developed country and China areas of well-being chronic liver disease, average adult NAFLD illness rate 10%~30%,
In 10%~20% be NASH, cirrhosis incidence is up to 25% in the latter 10 years.
Non-alcohol fatty liver in addition to it can directly result in decompensated liver cirrhosis, hepatocellular carcinoma and liver transplantation recur,
The progress of other chronic liver diseases can be also influenced, and participates in the morbidity of diabetes B and atherosclerosis.Metabolic syndrome is related
Malignant tumour, arteriosclerotic cardiovascular and cerebrovascular disease and cirrhosis are to influence patients with nonalcoholic fatty liver disease quality of life
And an important factor for life expectancy.For this purpose, non-alcohol fatty liver is the new challenge in contemporary medical science field, non-wine at no distant date
Essence fatty liver disease will be continuously increased the harm of human health.
It is non-alcohol fatty liver accompanied with abnormal hepatic function, metabolic syndrome, still invalid through Primary Care 3~6 months, with
And liver biopsy turns out to be NASH and the course of disease in Chronic Progressive by person, the drug auxiliary that can be used for hepatopathy is controlled
It treats, it, can be according to pharmaceutical properties and disease activity and stadium reasonable selection polyenoid phosphatide phthalein with anti-oxidant, anti-inflammatory, anti-fibrosis
The related drugs such as choline, vitamin E, silymarin and ursodesoxycholic acid, but cannot mostly eradicate and have side effect.
[summary of the invention]
In view of problem above, the present invention provides treatment nonalcoholic fatty liver eliminating toxic dampness and heat side, the treatment non-alcoholics
Fatty liver eliminating toxic dampness and heat side is made of plurality of Chinese, effectively eradicates nonalcoholic fatty liver and without any toxicity and side effects.
The technical problems to be solved by the invention are implemented with the following technical solutions:
A kind of to treat nonalcoholic fatty liver eliminating toxic dampness and heat side, mainly include the following raw material: lotus leaf, Rhizoma Atractylodis Macrocephalae, is determined at Poria cocos
Pine torch, semen coicis, rhizoma alismatis, umbellate pore furgus, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidate, oriental wormwood, Radix Astragali, Radix Glycyrrhizae, dried orange peel, radix bupleuri, radix paeoniae rubra, curcuma zedoary,
Radix Salviae Miltiorrhizae, Rheum palmatum (processed with wine).
Preferably, treatment nonalcoholic fatty liver eliminating toxic dampness and heat side includes the material of following weight: 5~20g of lotus leaf, Fu
12~30g of Siberian cocklebur, 10~20g of Rhizoma Atractylodis Macrocephalae, 20~30g of cassia seed, 25~35g of semen coicis, 10~20g of rhizoma alismatis, 5~15g of umbellate pore furgus, strand
5~25g of indigo plant, 10~15g of rhizoma pinellinae praeparata, 10~18g of polygonum cuspidate, 11~16g of oriental wormwood, 15~30g of Radix Astragali, 5~10g of Radix Glycyrrhizae, dried orange peel 6~
13g, 10~16g of radix bupleuri, 10~17g of radix paeoniae rubra, 8~19g of curcuma zedoary, 11~17g of Radix Salviae Miltiorrhizae, 7~20g of Rheum palmatum (processed with wine).
Preferably, treatment nonalcoholic fatty liver eliminating toxic dampness and heat side is mainly made of the material of following weight: treating non-wine
Essence fatty liver eliminating toxic dampness and heat side further includes the material for having following weight: lotus leaf 5g, Poria cocos 12g, Rhizoma Atractylodis Macrocephalae 10g, cassia seed 20g,
It is semen coicis 25g, rhizoma alismatis 10g, umbellate pore furgus 5g, gynostemma pentaphylla 5g, rhizoma pinellinae praeparata 10g, polygonum cuspidate 10g, oriental wormwood 11g, Radix Astragali 15g, Radix Glycyrrhizae 5g, old
Skin 6g, radix bupleuri 10g, radix paeoniae rubra 10g, curcuma zedoary 8g, Radix Salviae Miltiorrhizae 11g, Rheum palmatum (processed with wine) 7g.
Preferably, treatment nonalcoholic fatty liver eliminating toxic dampness and heat side further includes the material for having following weight: lotus leaf 17g, Fu
Siberian cocklebur 18g, Rhizoma Atractylodis Macrocephalae 16g, cassia seed 27g, semen coicis 29g, rhizoma alismatis 19g, umbellate pore furgus 14g, gynostemma pentaphylla 21g, rhizoma pinellinae praeparata 13g, polygonum cuspidate
16g, oriental wormwood 12g, Radix Astragali 18g, Radix Glycyrrhizae 9g, dried orange peel 11g, radix bupleuri 13g, radix paeoniae rubra 14g, curcuma zedoary 17g, Radix Salviae Miltiorrhizae 15g, Rheum palmatum (processed with wine) 17g.
Preferably, treatment nonalcoholic fatty liver eliminating toxic dampness and heat side further includes the material for having following weight: lotus leaf 20g, Fu
Siberian cocklebur 30g, Rhizoma Atractylodis Macrocephalae 20g, cassia seed 30g, semen coicis 35g, rhizoma alismatis 20g, umbellate pore furgus 15g, gynostemma pentaphylla 25g, rhizoma pinellinae praeparata 15g, polygonum cuspidate
18g, oriental wormwood 16g, Radix Astragali 30g, Radix Glycyrrhizae 10g, dried orange peel 13g, radix bupleuri 16g, radix paeoniae rubra 17g, curcuma zedoary 19g, Radix Salviae Miltiorrhizae 17g, Rheum palmatum (processed with wine)
20g。
The production method for treating nonalcoholic fatty liver eliminating toxic dampness and heat side, comprising the following steps:
1) choose lotus leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae, cassia seed, semen coicis, rhizoma alismatis, umbellate pore furgus, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidate, oriental wormwood,
Radix Astragali crushes to obtain powder, and powder addition water is carried out mixing and is put into pot, and the weight of water and the proportion of powder are 2: 1, intense fire
Then mild fire tanning is used in tanning 5~10 minutes instead；
2) betel nut Radix Glycyrrhizae, dried orange peel, radix bupleuri, radix paeoniae rubra, curcuma zedoary are put into casserole continuation mild fire to boil to boiling, are boiled subsequent
Continuous mild fire is put into Radix Salviae Miltiorrhizae, Rheum palmatum (processed with wine) after boiling 15~30 minutes, boils half an hour with mild fire, then cools down to medical fluid,
Medical fluid is obtained after filtering；
3) the resulting medical fluid of step 2) is concentrated, then particle is made, non-alcoholic fatty must be treated after dry water removal
Liver eliminating toxic dampness and heat side.
Polygonum cuspidate returns liver, the spleen channel, has hepatoprotective effect.
Rhizoma Atractylodis Macrocephalae can prevent and treat hepatic injury caused by carbon tetrachloride, mitigate hepatic glycogen reduction and degeneration of liver cells necrosis, promote
Liver cell increases, and declines raised ALT.
Umbellate pore furgus is sweet in flavor, light, mild-natured, can excreting dampness diuresis.Studies have shown that contained grifola polysaccharide in umbellate pore furgus, there is increase hepatic glycogen
Accumulation, promote liver cell regeneration effect.Umbellate pore furgus can improve the phagocytic activity to cell, promote the immune of cell, and have
Promote the generation effect of hepatitis surface antibody.
Radix Salviae Miltiorrhizae can improve Microcirculation of Liver, and antibody is inhibited to be formed, scavenging activated oxygen, improve liver function, and drop enzyme is dispelled Huang,
Promote liver cell regeneration.
Radix bupleuri returns liver, gallbladder channel, there is soothing liver-qi stagnation.And modern pharmacological research also indicates that, radix bupleuri has anti-hepatitis
Virus promotes immune function, the effect of liver protection.And clinically also it is mainly used for reducing with radix bupleuri liver-protecting tablet as main component
Transaminase restores liver function, reduces hepatic injury.
Lotus leaf plays the role of protecting liver cell, promote liver cell regeneration, degreasing and inhibiting liver cell fibrosis, can fight liver
One property of dysentery, one lesion.Curcumin and volatile oil can promote bile point one to secrete and arrange one to let out, it is first to reduce bird gallbladder in urinating；Decoction can pierce
Swash gastric acid and duodenal juice point one is secreted.Water decoction can reduce whole blood viscosity, inhibit platelet aggregation, and alcohol extract can reduce blood plasma
Fiber protein content.
Rhizoma alismatis has antibacterial action, is able to suppress the regeneration of gastrointestinal bacteria, moreover it is possible to inhibit the breeding of the duplication of liver virus, rise
To the effect of anti-inflammatory protect liver.
Though flat grams of gas for capable of grinding that product assaults fortified position that is apt in blood-breaking to enter liver of gynostemma pentaphylla taste cuts and relatively hurts positive eliminating mass
Void in addiction also diseases prevention.
Rhizoma pinellinae praeparata enters liver, lung two passes through.Major function rising Yang, is delivered, promoting eruption, removing toxic substances.
Oriental wormwood can promote gastrointestinal peristalsis；Antiulcer；Cholagogue；Relaxation tracheal smooth muscle；There is gonadotropic Effect；Maincenter fiber crops
Numbness；It is antibacterial；It is antitumor.The excited isolated rabbit intestines of decoction energy are shunk and are promoted in body rabbit enterocinesia, the first excitement of fennel oil, anethole
Intestinal tube is reinforced shrinking, and concentration, which increases, spasmolysis occurs；It is gavaged to animal or duodenal administration, irritability stomach can be inhibited to burst
Ulcer；To partially hepatectomized rat, fennel oil can be such that its liver regeneration degree increases；Propyl alcohol extract has gonadotropic Effect；In addition,
Also have the effects that CNS inhibition, anticoagulant anti-fibrinolytic.
By adopting the above-described technical solution, the invention has the following advantages: mainly using lotus leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae,
Cassia seed, semen coicis, rhizoma alismatis, umbellate pore furgus, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidate, oriental wormwood, Radix Astragali, Radix Glycyrrhizae, dried orange peel, radix bupleuri, radix paeoniae rubra, cowherb
The main component of art, Radix Salviae Miltiorrhizae, Rheum palmatum (processed with wine) as treatment nonalcoholic fatty liver eliminating toxic dampness and heat side, lotus leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae invigorating the spleen are seeped
It is wet；Cassia seed, semen coicis, rhizoma alismatis are soothing the liver in favor of eliminating toxic dampness and heat.Prescription is served as theme with eliminating toxic dampness and heat, assistant with soothing the liver, heat-clearing it
Product, happy liver network, removing summer-heat are hot and suffocating.The calming the liver invigorating the spleen, dampness removing resolving sputum, promoting promoting blood circulation have adjustment blood lipid, liver cell are promoted to repair
Function, treatment nonalcoholic fatty liver effect it is good, have no toxic side effect.
[specific embodiment]
The following examples can help those skilled in the art that the present invention is more fully understood, but cannot be with any
Mode limits the present invention.
Embodiment 1
Nonalcoholic fatty liver eliminating toxic dampness and heat side is treated mainly to be made of the material of following weight: lotus leaf 5g, Poria cocos 12g,
Rhizoma Atractylodis Macrocephalae 10g, cassia seed 20g, semen coicis 25g, rhizoma alismatis 10g, umbellate pore furgus 5g, gynostemma pentaphylla 5g, rhizoma pinellinae praeparata 10g, polygonum cuspidate 10g, oriental wormwood
11g, Radix Astragali 15g, Radix Glycyrrhizae 5g, dried orange peel 6g, radix bupleuri 10g, radix paeoniae rubra 10g, curcuma zedoary 8g, Radix Salviae Miltiorrhizae 11g, Rheum palmatum (processed with wine) 7g.
The production method for treating nonalcoholic fatty liver eliminating toxic dampness and heat side, comprising the following steps:
1) choose lotus leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae, cassia seed, semen coicis, rhizoma alismatis, umbellate pore furgus, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidate, oriental wormwood,
Radix Astragali crushes to obtain powder, and powder addition water is carried out mixing and is put into pot, and the weight of water and the proportion of powder are 2: 1, intense fire
Then mild fire tanning is used in tanning 5~10 minutes instead；
2) betel nut Radix Glycyrrhizae, dried orange peel, radix bupleuri, radix paeoniae rubra, curcuma zedoary are put into casserole continuation mild fire to boil to boiling, are boiled subsequent
Continuous mild fire is put into Radix Salviae Miltiorrhizae, Rheum palmatum (processed with wine) after boiling 15~30 minutes, boils half an hour with mild fire, then cools down to medical fluid,
Medical fluid is obtained after filtering；
3) the resulting medical fluid of step 2) is concentrated, then particle is made, non-alcoholic fatty must be treated after dry water removal
Liver eliminating toxic dampness and heat side.
Embodiment 2
Nonalcoholic fatty liver eliminating toxic dampness and heat side is treated mainly to be made of the material of following weight: lotus leaf 17g, Poria cocos 18g,
Rhizoma Atractylodis Macrocephalae 16g, cassia seed 27g, semen coicis 29g, rhizoma alismatis 19g, umbellate pore furgus 14g, gynostemma pentaphylla 21g, rhizoma pinellinae praeparata 13g, polygonum cuspidate 16g, oriental wormwood
12g, Radix Astragali 18g, Radix Glycyrrhizae 9g, dried orange peel 11g, radix bupleuri 13g, radix paeoniae rubra 14g, curcuma zedoary 17g, Radix Salviae Miltiorrhizae 15g, Rheum palmatum (processed with wine) 17g.
The production method for treating nonalcoholic fatty liver eliminating toxic dampness and heat side, comprising the following steps:
1) choose lotus leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae, cassia seed, semen coicis, rhizoma alismatis, umbellate pore furgus, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidate, oriental wormwood,
Radix Astragali crushes to obtain powder, and powder addition water is carried out mixing and is put into pot, and the weight of water and the proportion of powder are 2: 1, intense fire
Then mild fire tanning is used in tanning 5~10 minutes instead；
2) betel nut Radix Glycyrrhizae, dried orange peel, radix bupleuri, radix paeoniae rubra, curcuma zedoary are put into casserole continuation mild fire to boil to boiling, are boiled subsequent
Continuous mild fire is put into Radix Salviae Miltiorrhizae, Rheum palmatum (processed with wine) after boiling 15~30 minutes, boils half an hour with mild fire, then cools down to medical fluid,
Medical fluid is obtained after filtering；
3) the resulting medical fluid of step 2) is concentrated, then particle is made, non-alcoholic fatty must be treated after dry water removal
Liver eliminating toxic dampness and heat side.
Embodiment 3
Nonalcoholic fatty liver eliminating toxic dampness and heat side is treated mainly to be made of the material of following weight: lotus leaf 20g, Poria cocos 30g,
Rhizoma Atractylodis Macrocephalae 20g, cassia seed 30g, semen coicis 35g, rhizoma alismatis 20g, umbellate pore furgus 15g, gynostemma pentaphylla 25g, rhizoma pinellinae praeparata 15g, polygonum cuspidate 18g, oriental wormwood
16g, Radix Astragali 30g, Radix Glycyrrhizae 10g, dried orange peel 13g, radix bupleuri 16g, radix paeoniae rubra 17g, curcuma zedoary 19g, Radix Salviae Miltiorrhizae 17g, Rheum palmatum (processed with wine) 20g.
The production method for treating nonalcoholic fatty liver eliminating toxic dampness and heat side, comprising the following steps:
1) choose lotus leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae, cassia seed, semen coicis, rhizoma alismatis, umbellate pore furgus, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidate, oriental wormwood,
Radix Astragali crushes to obtain powder, and powder addition water is carried out mixing and is put into pot, and the weight of water and the proportion of powder are 2: 1, intense fire
Then mild fire tanning is used in tanning 5~10 minutes instead；
2) betel nut Radix Glycyrrhizae, dried orange peel, radix bupleuri, radix paeoniae rubra, curcuma zedoary are put into casserole continuation mild fire to boil to boiling, are boiled subsequent
Continuous mild fire is put into Radix Salviae Miltiorrhizae, Rheum palmatum (processed with wine) after boiling 15~30 minutes, boils half an hour with mild fire, then cools down to medical fluid,
Medical fluid is obtained after filtering；
3) the resulting medical fluid of step 2) is concentrated, then particle is made, non-alcoholic fatty must be treated after dry water removal
Liver eliminating toxic dampness and heat side.
Embodiment 4
Treatment nonalcoholic fatty liver eliminating toxic dampness and heat side be mainly made of following material: lotus leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae, cassia seed,
Semen coicis, rhizoma alismatis, umbellate pore furgus, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidate, oriental wormwood, Radix Astragali, Radix Glycyrrhizae, dried orange peel, radix bupleuri, radix paeoniae rubra, curcuma zedoary, Radix Salviae Miltiorrhizae,
Rheum palmatum (processed with wine).
The production method for treating nonalcoholic fatty liver eliminating toxic dampness and heat side, comprising the following steps:
1) choose lotus leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae, cassia seed, semen coicis, rhizoma alismatis, umbellate pore furgus, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidate, oriental wormwood,
Radix Astragali crushes to obtain powder, and powder addition water is carried out mixing and is put into pot, and the weight of water and the proportion of powder are 2: 1, intense fire
Then mild fire tanning is used in tanning 5~10 minutes instead；
2) betel nut Radix Glycyrrhizae, dried orange peel, radix bupleuri, radix paeoniae rubra, curcuma zedoary are put into casserole continuation mild fire to boil to boiling, are boiled subsequent
Continuous mild fire is put into Radix Salviae Miltiorrhizae, Rheum palmatum (processed with wine) after boiling 15~30 minutes, boils half an hour with mild fire, then cools down to medical fluid,
Medical fluid is obtained after filtering；
3) the resulting medical fluid of step 2) is concentrated, then particle is made, non-alcoholic fatty must be treated after dry water removal
Liver eliminating toxic dampness and heat side.
Experimental example
Random selection hospital's hepatopathy section is hospitalized and meets patient 140 of the standard of being included in, by successively coding of being hospitalized, random point
For A, B, C, D, E, F, G7 group.A group is treated using treatment nonalcoholic fatty liver eliminating toxic dampness and heat side made of embodiment 1；B
Group is treated using treatment nonalcoholic fatty liver eliminating toxic dampness and heat side made of embodiment 2；C group is using made of embodiment 3
Treatment nonalcoholic fatty liver eliminating toxic dampness and heat side is treated；D group is using removal lotus leaf, Poria cocos, Rhizoma Atractylodis Macrocephalae, Cassia in embodiment 1
Son, semen coicis, rhizoma alismatis, umbellate pore furgus, rear manufactured treatment nonalcoholic fatty liver eliminating toxic dampness and heat side are treated；E group is using implementation
After removing gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidate, oriental wormwood, Radix Astragali, Radix Glycyrrhizae, dried orange peel, radix bupleuri, radix paeoniae rubra, curcuma zedoary, Radix Salviae Miltiorrhizae, Rheum palmatum (processed with wine) in example 1
Manufactured treatment nonalcoholic fatty liver eliminating toxic dampness and heat side is treated；G group uses Western medicine Polyene Phosphatidylcholine capsule (Sino
The Beijing Fei Anwante pharmaceutical Co. Ltd, national drug standard H20059010,228mg/), 2 tablets/time, 3 times/day are treated；7
Group patient has comparativity in age, gender, the cause of disease, course of disease etc..Remaining six groups carry out medication 1 time daily, and seven groups of the course for the treatment of is equal
For 30 days for a course for the treatment of.Glutamic-pyruvic transaminase (ALT), the glutamic-oxalacetic transaminease (AST), total cholesterol of detection patient before and after treatment
(TC), triglycerides (TG), low density lipoprotein cholesterol (LDL~C) and the above index is compared.
Observe pretherapy and post-treatment hepatic fibrosis index variation comparison
Influence of the 1 each group therapeutic scheme of table to nonalcoholic fatty liver
Seen from table 1, after treating 1 course for the treatment of, ALT/ULL~1, TC/mmolL~1, TC/ of A, B, C group patient
MmolL~1, TG/mmolL~1, the content of LDL~C/mmolL~1 are decreased obviously, and have conspicuousness poor compared with other four groups
It is different.Prove that present invention treatment nonalcoholic fatty liver eliminating toxic dampness and heat side has lipid-loweringing, liver protection, protect liver and the work for subtracting " poison " synergy
With having apparent anti-nonalcoholic fatty liver effect, nonalcoholic fatty liver index can be made to be obviously improved.And treatment non-alcoholic
Fatty liver eliminating toxic dampness and heat side has that rapid-action, highly-safe, technical operation is simple, medicament sources are abundant, applied widely etc. excellent
Point is suitable for promoting and applying.And lacked it is any simply or multi-flavor medicine will be greatly reduced therapeutic effect.
Obese degree is positively correlated with pathogenesis of fatty liver rate, and insulin sensitivity reduces in overweight people's body, leads to liver rouge
Fat metabolism disorder, further causes blood lipid raising, and liver cell is impaired.
This interpretation of the cause, onset and process of an illness is the hot spleen deficiency of liver, phlegm wet stasis.It is mainly recorded in liver, " doctor's mirror at all times " its sick position: " hypochondriac pain or phlegm,
Product streamer mutually fights with blood in blood and is left disease "；It is recorded in Difficult Classic: " product of liver, name say fat gas "；Record in " bier ": " heresy exists
Liver, pain in two sides of body, in plug, including extravesated blood." close and join when place name doctor's Wang Jun quinoline four methods of diagnosis, and combine Modern human populations eating habit, it is believed that
NAFLD is mainly caused by dampness-heat of liver channel stasis blocking, and modern works, life stress leads to greatly stagnation of liver qi, long Yu Huare, and and thermophilic
It eats fatness, sweet, thick and oily and moves cause the insufficiency of the spleen with overabundance of dampness less, middle coke Qi dysfunction, wet and hot knot, strongly fragrant in Liver Channel, blockage of main and collateral channels turns to hemostasis, liver
Store blood is sent out as NAFLD, therefore treats and work as clearing liver clearing damp, promoting blood circulation and removing obstruction in channels, in accordance with the law from quasi- treatment nonalcoholic fatty liver eliminating toxic dampness and heat
Side.
Polygonum cuspidate clearing liver cool blood in we, Rheum palmatum (processed with wine) removing damp-heat from the liver and the gallbladder, lotus leaf dispersing liver and promoting blood circulation are altogether monarch drug in a prescription；Rhizoma alismatis, umbellate pore furgus
Polygonum cuspidate clearing liver cool blood is helped, oriental wormwood helps the clear liver and gallbladder damp-heat of stringy stonecrop, and it is altogether ministerial drug that Radix Salviae Miltiorrhizae, which helps lotus leaf cooling and activating blood, and mental-tranquilization,；
It is fennel, radix cynanchi atrati, humulus grass, rhizoma corydalis warming spleen and stomach for dispelling cold, eliminating dampness and eliminating phlegm, prevent it is cold and cool injure one's stomach, be adjutant.All medicines share plays clear sharp liver altogether
Gallbladder is damp and hot, activating microcirculation and removing stasis medicinal dissipating bind, the function that middle benefit gas is eliminating dampness and eliminating phlegm.Modern pharmacological studies have shown that polygonum cuspidate contains triterpenes, sterols etc.
Ingredient has the effects of lowering blood pressure and blood fat, hypoglycemic, anti-oxidant, free radical resisting, and in addition Prunella vulgaris is also adjusted endocrine
Function；Stringy stonecrop has the effects that liver protection, immunological regulation；Lotus leaf has the function of anti-oxidant, anti-inflammatory, platelet aggregation-against.
Party's clinical treatment shows apparent advantage.Our previous clinical researches, with treatment nonalcoholic fatty liver
Nonalcoholic fatty liver is treated by eliminating toxic dampness and heat side, and using diet motion control group as control, discovery we be can obviously reduce
Nonalcoholic fatty liver disease serum triglyceride is horizontal, mitigates patient's Liver fatty deposition degree.
Typical case
Mr. Bai, 43 years old.Because " physical examination discovery fatty liver more than 2 years, dysfunction of liver 1 week " is admitted to hospital.Two Nian Duoqian, Huan Zheti
It finds that fatty liver and serum triglyceride slightly increase when inspection, without special discomfort, does not give attention and further diagnosis and treatment.Before 1 week, suffer from
Person again physical examination when still show fatty liver, increased with serum transaminase, dyslipidemia and blood uric acid increase, no discomfort.It is clear
It is medical that diagnosis and treatment come the court.Onset is come, patient mental, stomach receive, sleep can, stool and urine is normal.Using treatment nonalcoholic fatty liver
The treatment of eliminating toxic dampness and heat side.By the treatment of a course for the treatment of, patient treats the state of an illness and improves significantly, repetition measurement weight 71.1kg after 3 months,
Abdominal circumference 90cm, check biochemical indicator are normal；Repetition measurement weight 67.8kg after 6 months, abdominal circumference 86cm, biochemical indicator is normal, abdomen
Portion's B ultrasound is shown no obvious abnormalities.
Huang, female, illness in 67 years old, medical history: without obvious inducement occurred starting occurring before March it is thin, originally without it is out of strength, receive
Difference；Started to occur before January it is out of strength, receive difference, no body mesh xanthochromia, no Nausea and vomiting, no abdominal distension, abdominal pain, diarrhea are no spitting blood, black
Just, no ecchymosis petechia；Out of strength before the 4 days, symptoms such as difference of receiving are further aggravated, in hospital have a blood test biochemistry show ALT 180U/L,
AST 140U/L, TBIL25.57U/L, DBIL7.94U/L, IDBIL17.63U/L, Hepatitis B virus show HBsAg (~), and B ultrasound mentions
Show " III degree of fatty liver "；Using the treatment for the treatment of nonalcoholic fatty liver eliminating toxic dampness and heat side；By the treatment of two courses for the treatment of, Huan Zhezhi
The state of an illness is treated to improve significantly.It is checked through hospital, liver function is normal, and GGT is significantly reduced, and fatty liver has disappeared.
Zhu, male tentative diagnosis on May 13 in 2017 41 years old, patient had found the illnesss such as fatty liver before 4 years when physical examination, not
Give the treatment of system, 1.75 meters of modern height, 95 kilograms of weight, figure is fat, blood pressure 158/100mmHg, dysfunction of liver, color
Super inspection is found to be moderate fatty liver, using the treatment for the treatment of nonalcoholic fatty liver eliminating toxic dampness and heat side；By controlling for course for the treatment of
It treats, 12 kilograms of weight loss, blood pressure is reduced to 130/90mmHg, and color ultrasound shows that fatty liver disappears, and liver function is normal
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, fall within the scope of the claimed invention without departing from theon the basis of the spirit of the present invention.
Claims (5)
1. a kind of treat nonalcoholic fatty liver eliminating toxic dampness and heat side, which is characterized in that mainly include the following raw material: lotus leaf, Fu
Siberian cocklebur, Rhizoma Atractylodis Macrocephalae, cassia seed, semen coicis, rhizoma alismatis, umbellate pore furgus, gynostemma pentaphylla, rhizoma pinellinae praeparata, polygonum cuspidate, oriental wormwood, Radix Astragali, Radix Glycyrrhizae, dried orange peel, radix bupleuri,
Radix paeoniae rubra, curcuma zedoary, Radix Salviae Miltiorrhizae, Rheum palmatum (processed with wine).
2. treatment nonalcoholic fatty liver eliminating toxic dampness and heat side according to claim 1, which is characterized in that the non-wine for the treatment of
Essence fatty liver eliminating toxic dampness and heat side includes the material of following weight: 5~20g of lotus leaf, 12~30g of Poria cocos, 10~20g of Rhizoma Atractylodis Macrocephalae,
20~30g of cassia seed, 25~35g of semen coicis, 10~20g of rhizoma alismatis, 5~15g of umbellate pore furgus, 5~25g of gynostemma pentaphylla, rhizoma pinellinae praeparata 10~
It is 15g, 10~18g of polygonum cuspidate, 11~16g of oriental wormwood, 15~30g of Radix Astragali, 5~10g of Radix Glycyrrhizae, 6~13g of dried orange peel, 10~16g of radix bupleuri, red
10~17g of Chinese herbaceous peony, 8~19g of curcuma zedoary, 11~17g of Radix Salviae Miltiorrhizae, 7~20g of Rheum palmatum (processed with wine).
3. treatment nonalcoholic fatty liver eliminating toxic dampness and heat side according to claim 2, which is characterized in that the non-wine for the treatment of
Essence fatty liver eliminating toxic dampness and heat side further includes the material for having following weight: lotus leaf 5g, Poria cocos 12g, Rhizoma Atractylodis Macrocephalae 10g, cassia seed 20g,
It is semen coicis 25g, rhizoma alismatis 10g, umbellate pore furgus 5g, gynostemma pentaphylla 5g, rhizoma pinellinae praeparata 10g, polygonum cuspidate 10g, oriental wormwood 11g, Radix Astragali 15g, Radix Glycyrrhizae 5g, old
Skin 6g, radix bupleuri 10g, radix paeoniae rubra 10g, curcuma zedoary 8g, Radix Salviae Miltiorrhizae 11g, Rheum palmatum (processed with wine) 7g.
4. treatment nonalcoholic fatty liver eliminating toxic dampness and heat side according to claim 2, which is characterized in that the non-wine for the treatment of
Essence fatty liver eliminating toxic dampness and heat side further includes the material for having following weight: lotus leaf 17g, Poria cocos 18g, Rhizoma Atractylodis Macrocephalae 16g, cassia seed 27g,
Semen coicis 29g, rhizoma alismatis 19g, umbellate pore furgus 14g, gynostemma pentaphylla 21g, rhizoma pinellinae praeparata 13g, polygonum cuspidate 16g, oriental wormwood 12g, Radix Astragali 18g, Radix Glycyrrhizae 9g,
Dried orange peel 11g, radix bupleuri 13g, radix paeoniae rubra 14g, curcuma zedoary 17g, Radix Salviae Miltiorrhizae 15g, Rheum palmatum (processed with wine) 17g.
5. treatment nonalcoholic fatty liver eliminating toxic dampness and heat side according to claim 2, which is characterized in that the non-wine for the treatment of
Essence fatty liver eliminating toxic dampness and heat side further includes the material for having following weight: lotus leaf 20g, Poria cocos 30g, Rhizoma Atractylodis Macrocephalae 20g, cassia seed 30g,
Semen coicis 35g, rhizoma alismatis 20g, umbellate pore furgus 15g, gynostemma pentaphylla 25g, rhizoma pinellinae praeparata 15g, polygonum cuspidate 18g, oriental wormwood 16g, Radix Astragali 30g, Radix Glycyrrhizae
10g, dried orange peel 13g, radix bupleuri 16g, radix paeoniae rubra 17g, curcuma zedoary 19g, Radix Salviae Miltiorrhizae 17g, Rheum palmatum (processed with wine) 20g.
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| CN111375004A (en) * | 2020-04-18 | 2020-07-07 | 黑龙江省医院 | Traditional Chinese medicine enema for treating non-alcoholic steatohepatitis and preparation method and application method thereof |
| CN113171415A (en) * | 2021-06-01 | 2021-07-27 | 李帅 | Traditional Chinese medicine composition for treating non-alcoholic fatty liver disease |
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| KR20150105616A (en) * | 2014-03-07 | 2015-09-17 | 동의대학교 산학협력단 | Composition comprising herbal extract for preventing or treating fatty liver disease |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111375004A (en) * | 2020-04-18 | 2020-07-07 | 黑龙江省医院 | Traditional Chinese medicine enema for treating non-alcoholic steatohepatitis and preparation method and application method thereof |
| CN111375004B (en) * | 2020-04-18 | 2021-10-26 | 黑龙江省医院 | Traditional Chinese medicine enema for treating non-alcoholic steatohepatitis and preparation method and application method thereof |
| CN113171415A (en) * | 2021-06-01 | 2021-07-27 | 李帅 | Traditional Chinese medicine composition for treating non-alcoholic fatty liver disease |
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