CN103055176B - Traditional Chinese medicine for treating diabetes mellitus and preparation method thereof - Google Patents
Traditional Chinese medicine for treating diabetes mellitus and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating diabetes mellitus. The traditional Chinese medicine comprises capillary wormwood herb, white mulberry root-bark, corn stigma, gizzard pepsin, semen sesami nigrum, dried sophora flower, trogopterus dung, liquorice, purslane and the like. The traditional Chinese medicine has the advantages that the medicine can treat both symptoms and root causes, has little side effects and a wide application range, and is obvious in blood sugar reducing effect, long in efficacy lasting effect and capable of stabilizing the blood sugar level of a diabetic.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, relate to a kind of Chinese medicine for the treatment of diabetes.
Background technology
Diabetes are by inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, the various virulence factors of Nervous and Mental Factors etc. act on body and cause hypoinsulinism, insulin resistant etc. and cause sugar, protein, fat, a series of metabolism disorder syndromes such as power and water Xie Zhi, clinically taking hyperglycemia as main feature, can there is polyuria in model case, polydipsia, polyphagia, the performance such as become thin, i.e. " three-many-one-little " symptom, diabetes (blood glucose) cause complication once control bad meeting, cause kidney, eye, the exhaustion pathological changes at the positions such as foot, and cannot cure.So, carry out suitable treatment at the initial stage of diabetes, can prevent further developing of the state of an illness.
The early symptom of diabetes is:
1. thirsty, polydipsia: because large quantity of moisture is discharged from urine with glucose, thus cause excess moisture to be lost, thus thirsty, great quantity of water drinking caused.
2. fatigue and weak: fatigue and weak is the symptom that diabetes the most often show.
3. eyestrain, visual deterioration; Eyes are easily tired, and vision sharply declines;
4. hunger and polyphagia: because the sugar part in body excretes out as glucose in urine, absorb the primary demand that maintains health less than enough heats, can usually feel abnormal hunger, appetite increases, but remain unchanged hunger as before;
The diabetes of diabetes (Diabetes) point type 1 diabetes, type 2 diabetes mellitus, gestational diabetes and other specific types.In diabetics, the shared ratio of type 2 diabetes mellitus is about 95%.
Type 1 diabetes (Type1diabetes) is a kind of autoimmune disease.Autoimmune disease is because the immune system of self forms self making attacking.The immune system of diabetics is made and is attacked and cause islet cells considerable damage the islet cells of self excreting insulin, and result pancreas can not be secreted enough insulins.The multiple teenager of being born in of type 1 diabetes, because insulin secretion lacks, relies on exogenous insulin and supplements to sustain life.
Insulin synthesis cell (β cell) in human pancreas is destroyed will initiation type diabetes.Although this paradiabetes is common in child and young patient, it can infect the crowd of any age bracket, and the prevalence of this paradiabetes accounts for 10% of total diabetes cases
Type 2 diabetes mellitus is adult's morbidity type diabetes, how after 35～40 years old, to fall ill, and accounts for diabetics more than 90%.The ability that produces insulin in patient body not completely loses, and in some patient bodies, insulin even produces too much, but the action effect of insulin has a greatly reduced quality, and therefore the insulin in patient body is a kind of shortage relatively.
Type 2 diabetes mellitus has stronger heritability and environmental factors, and is significant heterogeneity.Think that at present pathogenic factor is that (main manifestations is hyperinsulinemia to insulin resistant, glucose utilization rate reduces) and the merging existence of hypoinsulinism, its performance is inhomogenous, have taking insulin resistant as main with hypoinsulinism, have be with hypoinsulinism with or without insulin resistant.Insulin is the interior unique blood sugar lowering hormone of the health of human pancreas β emiocytosis.Insulin resistant refers to the Reduced susceptibility of surrounding tissue to insulin in body, and peripheral tissues promotes absorption, conversion, the utilization of glucose that opposing has occurred to insulin as muscle, fat.
Clinical observation insulin resistant is prevalent in type 2 diabetes mellitus, up to 90% left and right.Diabetes can cause infection, heart change, cerebrovascular disease, renal failure, lose the sight of both eyes, lower limb gangrene etc. and become the lethal main cause disabling.
Gestational diabetes refers to the diabetes that women suffers from phenolics.Clinical data shows that nearly 2～3% women, at phenolics, diabetes can occur, and patient's diabetes after gestation disappear automatically.
Gestational diabetes more easily occurs in obesity and lying-in woman advanced in years.There is 30% gestational diabetes women nearly may develop into type 2 diabetes mellitus later.
Because the causers such as pancreatitis, cancer, the excision of the large portion of pancreas should be considered in conjunction with medical history analysis.Patient has pigmentation, hepatosplenomegaly, and diabetes and Iron metabolism disorder evidence, should note differentiating, but more rare.Other endocrinopathys all respectively have feature, can be general without difficulty in conjunction with illness analysis when discriminating.Stress hyperglycemia or gestational diabetes should be followed up a case by regular visits to and be differentiated.Generally within 2 weeks after stress disappearing, can recover, or distinguish in following up a case by regular visits in a point puerperium.
The understanding of diabetes is focused on forming the root of diabetes from traditional Chinese medical science field, the traditional Chinese medical science thinks that leading diabetogenic reason has:
(1) congenital defect refers to due to parent fetal cultivation deficiency;
(2) day after tomorrow, loss was excessive: infringement as evil in poison, the cloudy Tianjin of loss;
(3) change source deficiency: the internal organs of giving birth to cloudy Tianjin as changed are impaired, and cloudy having no way of of essence is raw, suffers from a deficiency of the kidney;
(4) negative and positive relation imbalance between internal organs, causes cloudy damage too much eventually, and sun must be contained partially, and Yang Taisheng causes " disappearing ";
(5) eating and drinking without temperance, obesity;
(6) disorder of emotion, depression of liver-QI be because long-term feelings will is not relaxed, stasis heat-dissipating, injuring YIN due to production of dryness; Or because of rage, cause liver to lose bar and reach; Mechanism of qi retardance, also can heat-dissipating dryness-transformation, and cloudy Tianjin of the bright lung stomach that can disappear, causes lung dryness of the stomach heat, and thirsty polydipsia occurs, rapid digestion of food and polyorexia.With the passing of time the deficiency of YIN scorching, must cause deficiency of both QI and YIN.Deficiency of YIN affecting YANG and occur deficiency of QI and declination of YANG phenomenon, because lung, stomach, kidney three are through the cloudy deficiency of vital energy, the deficiency of both YIN and YANG disease that yang-energy is held back and occur;
(7) diseases caused by exogenous pathogenic factor six climate exopathogens, the evil infringement of poison diseases caused by exogenous pathogenic factor six climate exopathogens, invade loose cream (pancreas) in dryness-fire wind heat poison heresy, take up internal organs, and, also can there is diabetes in dryness-transformation impairment of body fluid.
At present, for the treatment of diabetes, main method has: diet control, exercise therapy, oral antidiabetic drug treatment and insulinize, but these methods are all cured the symptoms, not the disease.
Wherein, oral antidiabetic drug has: Drugs Promoting Insulin Secretion, biguanides, AGI etc., but when with this type of medicine,
(1) type 1 diabetes people (insulin-dependent);
(2) pregnant woman;
(3) obvious liver, the bad patient of renal function;
(4) take a large amount of blood sugar lowering person that still cannot well control blood glucose;
(5) serious whole body or local infection disease;
(6) significant stress situation, as capital operation, severe trauma, prohibit trencherman for a long time;
(7) take medicine allergy or be impatient at its side effect patient of boil on the nape opposite the mouth;
Above-mentioned seven class crowds can not take above-mentioned orally-taken blood sugar reducing medicine, so Drug therapy has significant limitation.
The symptom that insulinize adapts to is:
(1) type 1 diabetes patient, because self islet beta cell function is impaired, insulin secretion is definitely not enough, just needs insulinize in the time of morbidity, and needs lifelong insulin substitution to treat to sustain life and live.Account for diabetes total number of persons 5%;
(2) type 2 diabetes mellitus patient, on the basis of life style and Combined with Oral Antidiabetic Agents, if blood glucose does not still reach control target, can start the therapeutic alliance of oral drugs and insulin.When generally HbA1c is still greater than 7.0% after the multiple oral drugs therapeutic alliance of larger dose, just can consider to start insulinize, visible insulinize also has larger limitation.
Recently,, along with the popularization of Chinese medicine, increasing diabetics selects to take Chinese medicine and treats and control the state of an illness of diabetes.But the effect for the treatment of is all not obvious, cause most diabetics still in the torment in disease.
Summary of the invention
The technical problem to be solved in the present invention is to overcome above-mentioned defect, and a kind of Chinese medicine for the treatment of diabetes is provided, and the side effect in the process for the treatment of diabetes of this Chinese medicine is little, but therapeutic effect is obvious, and the preparation method of this Chinese medicine is also provided simultaneously.
For addressing the above problem, the technical solution adopted in the present invention is:
A Chinese medicine for the treatment of diabetes, is characterized in that, described Chinese medicine gram is made up of by weight following raw materials according:
10～20 grams of Herba Artemisiae Scopariaes, 5～10 grams of Cortex Mori, 1～3 gram of Stigma Maydis, 10～20 grams of 5～15 grams of Semen Sesami Nigrums of Endothelium Corneum Gigeriae Galli, 1～5 gram, dry Flos Sophorae, 10～20 grams of Oletum Trogopteroris, 5～20 grams of Radix Glycyrrhizae 10～20 Rana nigromaculata bitterroots, 10～30 grams of Fructus Lycii, 5～15 grams of Herba Agrimoniaes, 5～10 grams, 10～20 grams of Bombyx Batryticatus powder of Poria, 1～5 gram of Cortex Lycii, 10～30 grams of Radix Ginsengs, 5～15 grams of Radix Scrophulariaes, 10～20 grams of Radix Puerariaes, 5～10 grams of Rhizoma Coptidis, 5～20 grams of Cortex Moutans, 10～15 grams of Pericarpium Citri Reticulataes, 10～20 grams of Fructus Ligustri Lucidi, 5～15 grams of Flos Chrysanthemi Indicis, 10～20 grams of Ganoderma sinense Zhao Xu et Zhang, 5～15 grams of Fructus Schisandrae Chinensis.
Improve as one:
Described Chinese medicine is made up of by weight following raw materials according:
15 grams of Herba Artemisiae Scopariaes, 8 grams of Cortex Mori, 2 grams of Stigma Maydis, 10 grams of Endothelium Corneum Gigeriae Galli, 15 grams of Semen Sesami Nigrums, 3 grams, dry Flos Sophorae, 15 grams of Oletum Trogopteroris, 15 grams, Radix Glycyrrhizae, 12 grams of Herba Portulacaes, 20 grams of Fructus Lycii, 10 grams of Herba Agrimoniaes, 15 grams, Poria, 8 grams, Bombyx Batryticatus powder, 3 grams of Cortex Lycii, 20 grams of Radix Ginsengs, 10 grams of Radix Scrophulariaes, 15 grams of Radix Puerariaes, 7 grams of Rhizoma Coptidis, 15 grams of Cortex Moutans, 12 grams of Pericarpium Citri Reticulataes, 15 grams of Fructus Ligustri Lucidi, 10 grams of Flos Chrysanthemi Indicis, 15 grams of Ganoderma sinense Zhao Xu et Zhang, 10 grams of Fructus Schisandrae Chinensis.
As further improvement:
Described Chinese medicine is made up of by weight following raw materials according:
10 grams of Herba Artemisiae Scopariaes, 5 grams of Cortex Mori, 1 gram of Stigma Maydis, 5 grams of Endothelium Corneum Gigeriae Galli, 10 grams of Semen Sesami Nigrums, 1 gram, dry Flos Sophorae, 10 grams of Oletum Trogopteroris, 10 grams, Radix Glycyrrhizae, 5 grams of Herba Portulacaes, 10 grams of Fructus Lycii, 5 grams of Herba Agrimoniaes, 10 grams, Poria, 5 grams, Bombyx Batryticatus powder, 1 gram of Cortex Lycii, 10 grams of Radix Ginsengs, 5 grams of Radix Scrophulariaes, 10 grams of Radix Puerariaes, 5 grams of Rhizoma Coptidis, 5 grams of Cortex Moutans, 10 grams of Pericarpium Citri Reticulataes, 10 grams of Fructus Ligustri Lucidi, 5 grams of Flos Chrysanthemi Indicis, 10 grams of Ganoderma sinense Zhao Xu et Zhang, 5 grams of Fructus Schisandrae Chinensis.
As further improving:
Described Chinese medicine is made up of by weight following raw materials according:
20 grams of Herba Artemisiae Scopariaes, 10 grams of Cortex Mori, 3 grams of Stigma Maydis, 15 grams of Endothelium Corneum Gigeriae Galli, 20 grams of Semen Sesami Nigrums, 5 grams, dry Flos Sophorae, 20 grams of Oletum Trogopteroris, 20 grams, Radix Glycyrrhizae, 20 grams of Herba Portulacaes, 30 grams of Fructus Lycii, 15 grams of Herba Agrimoniaes, 20 grams, Poria, 10 grams, Bombyx Batryticatus powder, 5 grams of Cortex Lycii, 30 grams of Radix Ginsengs, 15 grams of Radix Scrophulariaes, 20 grams of Radix Puerariaes, 10 grams of Rhizoma Coptidis, 20 grams of Cortex Moutans, 15 grams of Pericarpium Citri Reticulataes, 20 grams of Fructus Ligustri Lucidi, 15 grams of Flos Chrysanthemi Indicis, 20 grams of Ganoderma sinense Zhao Xu et Zhang, 15 grams of Fructus Schisandrae Chinensis.
As further improving:
A preparation method for the treatment of the Chinese medicine of diabetes, is characterized in that: described method has following steps:
A, get the raw materials ready, be on the waiting list each Chinese herb by above-mentioned weight;
B, immersion, soak half an hour after Chinese herb is mixed;
C, decoction, first put into crucible very hot oven and decoct half an hour, then temperature fire decocts 45 minutes, and after elimination medicinal residues, then temperature fire decocts half an hour, just medicinal liquid.
Every part of Chinese medicine gained medicinal liquid is taken at twice, and sooner or later respectively once, drink ante cibum, and ten days courses for the treatment of, be a stage three courses for the treatment of, and the two weeks of stopping using, carries out second stage, three phases altogether, interval two weeks of each stage, four months total used times of three phases.
Herba Artemisiae Scopariae has blood fat reducing, coronary artery dilating and fibrinolysis activity, hypotensive activity and antibacterial, antiinflammation.Mainly utilize in the present invention the blood fat reducing of Herba Artemisiae Scopariae, the effect of blood pressure lowering, be about to eliminate the disease of the diabetes head that rises.
Cortex Mori has eliminating pathogen from the lung for relieving asthma, effect of inducing diuresis to remove edema.Mainly utilize in the present invention effect of Cortex Mori inducing diuresis to remove edema, for diseases such as the dysuria of diabetes.
Stigma Maydis has diuresis, expels the heat-evil, and suppressing the hyperactive liver, effect of function of gallbladder promoting, is used for the treatment of oedema due to nephritis, beriberi, icterohepatitis, hypertension, cholecystitis, cholelithiasis, diabetes, hematemesis and epistaxis, nasal sinusitis, the symptoms such as acute mastitis, and the main diuresis of Stigma Maydis, effect of function of gallbladder promoting utilized in the present invention, for reducing blood glucose, treatment diabetes.
Endothelium Corneum Gigeriae Galli has effect of promoting digestion and invigorating the stomach, and after the oral Endothelium Corneum Gigeriae Galli of people, gastric secretion, acidity and eupepsy all have and increase, and gastric motor function obviously strengthens, and shows the prolongation of stomach moving period and the enhancing of peristalsis.Due to the enhancing of stomach motion, therefore, gastric emptying rate is also accelerated greatly, mainly utilizes effect of Endothelium Corneum Gigeriae Galli promoting digestion and invigorating the stomach in the present invention, to regulate the diet of diabetics, prevents immune system disorder.
Semen Sesami Nigrum has invigorating the liver and kidney, benefiting essence-blood, and effect that intestine moistening is dry, and in to the blood sugar test of rat, Oral Administration in Rats Semen Sesami Nigrum seed extract, can make its blood glucose reduce, and can increase glycogen content in its liver and muscle, but reduce glycogen content in a large number.
Dry Flos Sophorae has the effect of blood fat reducing, can effectively reduce cholesterol level, and increases the stability of cholesterol-albumen composition.
Oletum Trogopterori is sweet in flavor and warm in property, nontoxic, enters Liver Channel, has dredging blood vessel, and effect of eliminating stasis to stop pain is mainly utilized effect of Oletum Trogopterori dredging blood vessel in the present invention, regulate the immune system of diabetics.
Herba Portulacae has heat-clearing and toxic substances removing, and diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, effect of hemostasis removing heat from blood.Cure mainly the symptoms such as nephritis, in the present invention, mainly utilize effect of Herba Portulacae inducing diuresis to remove edema, because it contains abundant norepinephrine, can promote pancreas islet gland excreting insulin, regulate human body carbohydrate metabolism process, reduce blood sugar concentration, keep blood glucose constant, so diabetes are had to certain therapeutical effect.
Fructus Lycii has nourishing the liver and kidney, effect of replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.Wolfberry fruit extract can significantly and lastingly reduce rat blood sugar, increase carbohydrate tolerance, and toxicity is less.
Herba Agrimoniae has heart tonifying, rises blood pressure, blood coagulation, hemostasis, removing heat from blood, the effect such as antibacterial, for regulating patient's immune system.
Poria can spleen invigorating, again can eliminating dampness by diuresis, and can also enhancing human body immunity function.
Bombyx Batryticatus has expelling wind for relieving convulsion, effect of dissipating phlegm and resolving masses, and Bombyx Batryticatus powder has hypoglycemic effect.
The hyperglycemia that Cortex Lycii causes for Injection of Adrenaline there is no obvious antagonism, holds time but can shorten hyperglycemia.Rabbit subcutaneous injection Cortex Lycii extractum, also can make blood glucose reduce.Cortex Lycii water decoction has certain effect that alleviates to the morphosis infringement of alloxan diabetes mouse islets B cell.Cortex Lycii extractum gavage, can make Experimental Rabbit serum total cholesterol content decline, but little on content of triglyceride impact, and hepatic fat content is also had no significant effect.Betanin in Cortex Lycii has lipotropy, mainly utilizes in the present invention Cortex Lycii blood sugar lowering and effect for reducing blood fat.
The hyperglycemia that Radix Ginseng causes to euglycemia and because of Injection of Adrenaline and hypertonic glucose all has inhibitory action, to the alloxan diabetes of male rat, there is the effect of controlling blood sugar level, to Canis familiaris L. artificial diabetes hyperglycemia, there is certain inhibitory action, the different Saponin monomers of Radix Ginseng can strengthen insulin to glycometabolic impact to the effect of antiadrenergic drug, ACTH and glucagon, Radix Ginseng total saponins can stimulate the rat Langerhans islet uelralante of separation, and can promote the insulin that glucose causes to discharge.Give normal person and decoction being taken at a draught red ginseng powder 3～6g of diabetes patient or saponin component, there is reduction trend in blood glucose, in blood, gastrin increases, cortex acetone number diabetes patient have decline and on the rise normal person, catechol amine number has downward trend, adenyl cyclase on catecholaminergic active cell film, cAMP is raise, promote gluconeogenesis, Radix Ginseng Rubra can make changes of Catecholamine Content reduce, thereby limit gluconeogenesis, cause glycometabolic adjusting, Radix Ginseng has dual regulation to carbohydrate metabolism, can make the blood glucose of the hyperglycemia of glucose reduce, can make again the blood sugar increasing of the hypoglycemia that insulin causes.
Radix Scrophulariae has clearing away heat and cooling blood, effect of eliminating fire and detoxication, and the fluid extract of Radix Scrophulariae, to normal rabbits subcutaneous injection, can make Rabbits ' Blood Sugar reduce, therefore Radix Scrophulariae has the effect of blood glucose.
Radix Puerariae in Radix Puerariae have and significantly falls hypoglycemic effect, and the contained flavone compound of Radix Puerariae has effect for reducing blood fat, can reduce serum cholesterol, reduces oily three esters, is used for the treatment of hyperglycemia, and hyperlipidemia disease, has significant curative effect.
Berberine in Rhizoma Coptidis has hypotensive effect, and the diabetes that cause for hypertension can be eliminated source of disease.
Effective ingredient in Cortex Moutan all has potentiation to body fluid and cellular immunization as paeonol, paeoniflorin, oxypaeoniflorin etc., and paeonol, paeoniflorin have inhibitory action to the steatolysis of the lipocyte due to epinephrine; Cortex Moutan water extract can increase glucose in lipocyte and generate fat, and the glucose obviously increasing due to insulin generates fat.
Pericarpium Citri Reticulatae has effect of regulating qi-flowing for strengthening spleen, antiinflammatory function of gallbladder promoting.
Fructus Ligustri Lucidi tonifying liver kidney yin, the improving eyesight of crow palpus, for the hepatic and renal YIN deficiency, soreness of waist tinnitus, the red Alto symptom of order.
Flos Chrysanthemi Indici has efficacy in lowering high blood pressure by antiadrenergic drug and expansion peripheral blood vessel, the diabetes successful causing for hypertension.
Ganoderma sinense Zhao Xu et Zhang not only has direct hypoglycemic activity, and share and can increase curative effect with the hypoglycemic drug of former use, prevent or alleviate complication, in the situation that blood glucose remains normal and stable, the former dosage with blood sugar lowering that can cut down according to the circumstance as the case may be, to reduce adverse effect.The hepatoprotective effect that Ganoderma sinense Zhao Xu et Zhang itself has also can alleviate or prevent some oral hypoglycemic thing infringements to liver, and the principle of Ganoderma sinense Zhao Xu et Zhang blood sugar lowering is owing to promoting tissue to sugared utilization.After taking Ganoderma, disengaging of insulin inhibition fatty acid can be replaced, the symptom such as blood glucose, glucose in urine can be improved.Blood glucose is down to 116 by 173, and cholesterol is down to 179 by 233, and beta-protein is down to 465 by 580.Water soluble polysaccharide in Ganoderma, can alleviate the occurring degree of non-insulin-dependent diabetes mellitus.
Fructus Schisandrae Chinensis can promote the synthetic of hepatic glycogen, and carbohydrate metabolism is strengthened, and can increase again the synthetic of Hepatocyte matter, can the defence capability of enhancing body to nonspecific stimulation.
Radix Glycyrrhizae has antiinflammatory, antiviral, and protecting liver and detoxication and strengthen the effect such as immunologic function, mainly utilizes Radix Glycyrrhizae to strengthen the immunologic function of diabetics in the present invention.
In sum, in the present invention, taking Stigma Maydis, Herba Portulacae, Fructus Lycii, Semen Sesami Nigrum, Cortex Lycii, Bombyx Batryticatus powder, Radix Ginseng, Radix Scrophulariae, Radix Puerariae, Ganoderma sinense Zhao Xu et Zhang as monarch drug, for reducing blood glucose, taking Endothelium Corneum Gigeriae Galli, Oletum Trogopterori, Herba Agrimoniae, Poria, Cortex Moutan, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Radix Glycyrrhizae as ministerial drug, for regulating the immune system of human body, taking Flos Chrysanthemi Indici, Rhizoma Coptidis as adjuvant drug, for reducing hypertension, with Herba Artemisiae Scopariae, Cortex Mori, Pericarpium Citri Reticulatae for making medicine, for suppressing the hyperactive liver function of gallbladder promoting, protect the liver and protect kidney.Be monarch, the minister said in the traditional Chinese medical science, help, make, so, after above-mentioned Chinese medicine ingredients is mixed, both can bring into play the effect of self, also can with other components matching, complement each other, learn from other's strong points to offset one's weaknesses, make whole medicine perform to maximum effect, be convenient to treatment and control to diabetes.
In order further to verify the property of medicine of the present invention and drug effect, utilize white mice to carry out drug test, select diabetics to carry out the test of pesticide effectiveness.
Drug test:
Choose three groups of white mice, five every group, make three groups of white mice be hyperglycemia test body by anthropic factor, wherein first group as a control group, second group of injecting normal saline, the 3rd group pours into the medicinal liquid after decoction of the present invention, press 10g/Kg consumption, once a day, continuous ten days, after ten days, again three groups of white mice are checked UP, find, the blood glucose amount of first group and second group white mice is substantially constant, and vital sign declines, the 3rd group of blood glucose obviously declines, vital signs stable.As can be seen here, medicine of the present invention has no side effect to human body, and blood sugar decreasing effect is obvious.
Effect experiment:
Choose 100 diabeticss, wherein type 1 diabetes patient 12 people, type 2 diabetes mellitus patient 78 people, patients with gestational diabetes 10 people, all take medicine of the present invention, once-a-day, drink ante cibum, ten days courses for the treatment of, be a stage three courses for the treatment of, the two weeks of stopping using, carry out second stage, three phases altogether, interval two weeks of each stage, four months total used times of three phases.After four months, glycolated hemoglobin (Alc) to above-mentioned 100 diabeticss, fasting glucose (FPG), oral glucose tolerance (2h sugar amount) check UP, wherein be defined as on an empty stomach at least interior empty calory of 8h and take in *, * when without clear and definite hyperglycemia, should carry out confirmation standard 1～3 by duplicate detection.The result of health check-up as shown in Table 1.
Table one
As can be seen from Table I, the present invention has effect significantly to the treatment of diabetics, and can stablize indices, has reduced the misery of diabetics, has improved the quality of life of diabetics.
In process of the test, above-mentioned diabetics has been carried out to all-the-way tracking record, particular content is as shown in Table 2.
Table two
Owing to having adopted technique scheme, the present invention has the following advantages:
(1) the present invention starts with from root, treating both the principal and secondary aspects of a disease, and blood sugar decreasing effect is obvious;
(2) side effect is little;
(3) scope of application is wide, is suitable for all kinds of diabeticss, comprises anemia of pregnant woman;
(4) efficacy of a drug persistent period long, can stablize the blood glucose amount of diabetics.
Below in conjunction with detailed description of the invention, the present invention will be further described.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine for the treatment of diabetes, choose 15 grams of Herba Artemisiae Scopariaes, 8 grams of Cortex Mori, 2 grams of Stigma Maydis, 10 grams of Endothelium Corneum Gigeriae Galli, 15 grams of Semen Sesami Nigrums, 3 grams, dry Flos Sophorae, 15 grams of Oletum Trogopteroris, 15 grams, Radix Glycyrrhizae, 12 grams of Herba Portulacaes, 20 grams of Fructus Lycii, 10 grams of Herba Agrimoniaes, 15 grams, Poria, 8 grams, Bombyx Batryticatus powder, 3 grams of Cortex Lycii, 20 grams of Radix Ginsengs, 10 grams of Radix Scrophulariaes, 15 grams of Radix Puerariaes, 7 grams of Rhizoma Coptidis, 15 grams of Cortex Moutans, 12 grams of Pericarpium Citri Reticulataes, 15 grams of Fructus Ligustri Lucidi, 10 grams of Flos Chrysanthemi Indicis, 15 grams of Ganoderma sinense Zhao Xu et Zhang, 10 grams of mixing of Fructus Schisandrae Chinensis, decoct, first put into crucible very hot oven and decoct half an hour, temperature fire decocts 45 minutes again, after elimination medicinal residues, temperature fire decocts half an hour again, just obtain medicinal liquid, every part of Chinese medicine gained medicinal liquid is taken at twice, sooner or later respectively once, drink ante cibum.
Above-mentioned dosage is applicable to the general patient of diabetes.
Embodiment 2: a kind of Chinese medicine for the treatment of diabetes, choose 10 grams of Herba Artemisiae Scopariaes, 5 grams of Cortex Mori, 1 gram of Stigma Maydis, 5 grams of Endothelium Corneum Gigeriae Galli, 10 grams of Semen Sesami Nigrums, 1 gram, dry Flos Sophorae, 10 grams of Oletum Trogopteroris, 10 grams, Radix Glycyrrhizae, 5 grams of Herba Portulacaes, 10 grams of Fructus Lycii, 5 grams of Herba Agrimoniaes, 10 grams, Poria, 5 grams, Bombyx Batryticatus powder, 1 gram of Cortex Lycii, 10 grams of Radix Ginsengs, 5 grams of Radix Scrophulariaes, 10 grams of Radix Puerariaes, 5 grams of Rhizoma Coptidis, 5 grams of Cortex Moutans, 10 grams of Pericarpium Citri Reticulataes, 10 grams of Fructus Ligustri Lucidi, 5 grams of Flos Chrysanthemi Indicis, 10 grams of Ganoderma sinense Zhao Xu et Zhang, 5 grams of mixing of Fructus Schisandrae Chinensis, decoct, first put into crucible very hot oven and decoct half an hour, temperature fire decocts 45 minutes again, after elimination medicinal residues, temperature fire decocts half an hour again, just obtain medicinal liquid, every part of Chinese medicine gained medicinal liquid is taken at twice, sooner or later respectively once, drink ante cibum.
Above-mentioned dosage is applicable to the lighter patient of the diabetes state of an illness.
Embodiment 3: a kind of Chinese medicine for the treatment of diabetes, choose 20 grams of Herba Artemisiae Scopariaes, 10 grams of Cortex Mori, 3 grams of Stigma Maydis, 15 grams of Endothelium Corneum Gigeriae Galli, 20 grams of Semen Sesami Nigrums, 5 grams, dry Flos Sophorae, 20 grams of Oletum Trogopteroris, 20 grams, Radix Glycyrrhizae, 20 grams of Herba Portulacaes, 30 grams of Fructus Lycii, 15 grams of Herba Agrimoniaes, 20 grams, Poria, 10 grams, Bombyx Batryticatus powder, 5 grams of Cortex Lycii, 30 grams of Radix Ginsengs, 15 grams of Radix Scrophulariaes, 20 grams of Radix Puerariaes, 10 grams of Rhizoma Coptidis, 20 grams of Cortex Moutans, 15 grams of Pericarpium Citri Reticulataes, 20 grams of Fructus Ligustri Lucidi, 15 grams of Flos Chrysanthemi Indicis, 20 grams of Ganoderma sinense Zhao Xu et Zhang, 15 grams of mixing of Fructus Schisandrae Chinensis, decoct, first put into crucible very hot oven and decoct half an hour, temperature fire decocts 45 minutes again, after elimination medicinal residues, temperature fire decocts half an hour again, just obtain medicinal liquid, every part of Chinese medicine gained medicinal liquid is taken at twice, sooner or later respectively once, drink ante cibum.
Ten days courses for the treatment of, be a stage three courses for the treatment of, and three phases just can effectively reduce and control blood glucose altogether.
Above-mentioned dosage is applicable to the heavier patient of the diabetes state of an illness.
The classical case of part:
Case 1: Wang, female, 56 years old, suffer from type 2 diabetes mellitus and have 5 years, its random blood sugar, up to 15.0mmol/L, sustains life by insulin injection, patient starts to take Chinese medicine of the present invention from August, 2011, and after first quarter moon, blood glucose starts steady decline, and after one month, glucose in urine transfers feminine gender to, health approaches normal condition, blood sugar recovery is normal after two months, and liver function, renal function improve, and islet function impaired after four months is restored, patient is energetic, and blood fat, blood pressure become stable.
Case 2: summer, man, 65 years old, suffer from type 2 diabetes mellitus and have 7 years, vision degradation, almost blind, other complication is also very serious, sustain life by insulin injection, patient starts to take medicine of the present invention from JIUYUE, 2011, after first quarter moon, blood glucose starts steady decline, after one month, glycemic control is in more satisfactory scope, thirsty polydipsia, frequent micturition, hungry, the situations such as tired weakness are all alleviated to some extent, blood sugar recovery is normal after two months, along with the raising of body immunity, patient is energetic, full of physical strength, islet function impaired after four months is restored, patient is energetic, blood fat, it is stable that blood pressure becomes, patient reduces hypoglycemic medicine gradually.
Case 3: Lee, man, 32 years old, find the year before and suffer from type 1 diabetes, with thirsty polydipsia, frequent micturition, hungry, tired weak, patient starts to take medicine of the present invention from JIUYUE, 2011, after first quarter moon, blood glucose starts steady decline, thirsty polydipsia after one month, frequent micturition, hungry, the symptoms such as tired weakness are alleviated to some extent, blood sugar recovery is normal after two months, subjective symptoms disappears, liver function, renal function be improved significantly, the raising of body immunity after three months, quality of life obviously improves, patient is energetic, full of physical strength, impaired islet function is restored.
Case 4: high certain, female, 28 years old, the blood glucose of having a medical check-up conceived seven months time was low, after suffer from gestational diabetes, start to take medicine of the present invention from October, 2011, after one month, blood glucose recovers normal substantially, patient is energetic after two months, full of physical strength, and the islet function of damage is restored.
Case 5: Cai, female, 60 years old, there is diabetic history 4 years, and with multiple complications, sustain life by insulin, patient starts to take medicine of the present invention from JIUYUE, 2011, after one month, blood glucose starts steady decline, and complication is alleviated to some extent, and blood sugar recovery is normal after two months, impaired islet function is restored, patient is energetic, and blood fat, blood pressure become stable, and patient reduces hypoglycemic medicine gradually.
Claims (5)
1. a Chinese medicine for the treatment of diabetes, is characterized in that, described Chinese medicine gram is made up of by weight following raw materials according:
10～20 grams of Herba Artemisiae Scopariaes, 5～10 grams of Cortex Mori, 1～3 gram of Stigma Maydis, 5～15 grams of Endothelium Corneum Gigeriae Galli, 10～20 grams of Semen Sesami Nigrums, 1～5 gram, dry Flos Sophorae, 10～20 grams of Oletum Trogopteroris, 10～20 grams, Radix Glycyrrhizae, 5～20 grams of Herba Portulacaes, 10～30 grams of Fructus Lycii, 5～15 grams of Herba Agrimoniaes, 10～20 grams, Poria, 5～10 grams, Bombyx Batryticatus powder, 1～5 gram of Cortex Lycii, 10～30 grams of Radix Ginsengs, 5～15 grams of Radix Scrophulariaes, 10～20 grams of Radix Puerariaes, 5～10 grams of Rhizoma Coptidis, 5～20 grams of Cortex Moutans, 10～15 grams of Pericarpium Citri Reticulataes, 10～20 grams of Fructus Ligustri Lucidi, 5～15 grams of Flos Chrysanthemi Indicis, 10～20 grams of Ganoderma sinense Zhao Xu et Zhang, 5～15 grams of Fructus Schisandrae Chinensis.
2. a kind of Chinese medicine for the treatment of diabetes according to claim 1, is characterized in that, described Chinese medicine is made up of by weight following raw materials according:
15 grams of Herba Artemisiae Scopariaes, 8 grams of Cortex Mori, 2 grams of Stigma Maydis, 10 grams of Endothelium Corneum Gigeriae Galli, 15 grams of Semen Sesami Nigrums, 3 grams, dry Flos Sophorae, 15 grams of Oletum Trogopteroris, 15 grams, Radix Glycyrrhizae, 12 grams of Herba Portulacaes, 20 grams of Fructus Lycii, 10 grams of Herba Agrimoniaes, 15 grams, Poria, 8 grams, Bombyx Batryticatus powder, 3 grams of Cortex Lycii, 20 grams of Radix Ginsengs, 10 grams of Radix Scrophulariaes, 15 grams of Radix Puerariaes, 7 grams of Rhizoma Coptidis, 15 grams of Cortex Moutans, 12 grams of Pericarpium Citri Reticulataes, 15 grams of Fructus Ligustri Lucidi, 10 grams of Flos Chrysanthemi Indicis, 15 grams of Ganoderma sinense Zhao Xu et Zhang, 10 grams of Fructus Schisandrae Chinensis.
3. a kind of Chinese medicine for the treatment of diabetes according to claim 1, is characterized in that, described Chinese medicine is made up of by weight following raw materials according:
10 grams of Herba Artemisiae Scopariaes, 5 grams of Cortex Mori, 1 gram of Stigma Maydis, 5 grams of Endothelium Corneum Gigeriae Galli, 10 grams of Semen Sesami Nigrums, 1 gram, dry Flos Sophorae, 10 grams of Oletum Trogopteroris, 10 grams, Radix Glycyrrhizae, 5 grams of Herba Portulacaes, 10 grams of Fructus Lycii, 5 grams of Herba Agrimoniaes, 10 grams, Poria, 5 grams, Bombyx Batryticatus powder, 1 gram of Cortex Lycii, 10 grams of Radix Ginsengs, 5 grams of Radix Scrophulariaes, 10 grams of Radix Puerariaes, 5 grams of Rhizoma Coptidis, 5 grams of Cortex Moutans, 10 grams of Pericarpium Citri Reticulataes, 10 grams of Fructus Ligustri Lucidi, 5 grams of Flos Chrysanthemi Indicis, 10 grams of Ganoderma sinense Zhao Xu et Zhang, 5 grams of Fructus Schisandrae Chinensis.
4. a kind of Chinese medicine for the treatment of diabetes according to claim 1, is characterized in that, described Chinese medicine is made up of by weight following raw materials according:
20 grams of Herba Artemisiae Scopariaes, 10 grams of Cortex Mori, 3 grams of Stigma Maydis, 15 grams of Endothelium Corneum Gigeriae Galli, 20 grams of Semen Sesami Nigrums, 5 grams, dry Flos Sophorae, 20 grams of Oletum Trogopteroris, 20 grams, Radix Glycyrrhizae, 20 grams of Herba Portulacaes, 30 grams of Fructus Lycii, 15 grams of Herba Agrimoniaes, 20 grams, Poria, 10 grams, Bombyx Batryticatus powder, 5 grams of Cortex Lycii, 30 grams of Radix Ginsengs, 15 grams of Radix Scrophulariaes, 20 grams of Radix Puerariaes, 10 grams of Rhizoma Coptidis, 20 grams of Cortex Moutans, 15 grams of Pericarpium Citri Reticulataes, 20 grams of Fructus Ligustri Lucidi, 15 grams of Flos Chrysanthemi Indicis, 20 grams of Ganoderma sinense Zhao Xu et Zhang, 15 grams of Fructus Schisandrae Chinensis.
5. the preparation method of a kind of Chinese medicine for the treatment of diabetes described in one of them according to claim 1 to 4, is characterized in that: described method has following steps:
A, get the raw materials ready, be on the waiting list each Chinese herb by above-mentioned weight;
B, immersion, soak half an hour after Chinese herb is mixed;
C, decoction, first put into crucible very hot oven and decoct half an hour, then temperature fire decocts 45 minutes, and after elimination medicinal residues, then temperature fire decocts half an hour, just medicinal liquid.
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