CN104027643A - Traditional Chinese medicine composition for treating diabetes - Google Patents
Traditional Chinese medicine composition for treating diabetes Download PDFInfo
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- CN104027643A CN104027643A CN201410258992.8A CN201410258992A CN104027643A CN 104027643 A CN104027643 A CN 104027643A CN 201410258992 A CN201410258992 A CN 201410258992A CN 104027643 A CN104027643 A CN 104027643A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating diabetes. The traditional Chinese medicine composition comprises 10-20g of fragrant solomonseal rhizome, 10-20g of glossy privet fruit, 10-20g of glutinous rice, 10-20g of gypsum, 10-20g of heterophylly falsestarwort root, 10-20g of costustoot, 5-10g of oriental waterplantain rhizome, 5-10g of mongolian dandelion herb and 5-10g of dendrobium. The traditional Chinese medicine composition disclosed by the invention has the fasting blood-glucose curative effect significant efficiency of 32.1-53.5% and the postprandial blood sugar significant efficiency of 38.2-63.2% after treating diabetes on the basis of the principle of resolving the current problems and eliminating the root causes in traditional Chinese medicines, has a certain repairing effect on pancreatic tissue damages caused by tetraoxypyrimidine, has a certain increase tread on insulin release of diabetic patients after treatment, has significantly-increased postprandial serum insulin, and obviously improves the diabetes symptoms. Clinical experiments show that the traditional Chinese medicine composition disclosed by the invention is safe in taking and reliable in curative effect, and can not cause abnormal influences and other adverse reactions and side or toxic effects on the heart, liver and kidney functions and blood systems.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine composition that can treat diabetes.
Background technology
Diabetes are one group of metabolic diseases taking hyperglycemia as feature, hyperglycemia be due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause.The long-standing hyperglycemia of diabetes, cause various tissues, particularly chronic lesion, the dysfunction of eye, kidney, heart, blood vessel, nerve, have a strong impact on patient's physical and mental health, and bring serious burden to individual, family and society, day by day become the important Chronic Non-Communicable Diseases of serious harm people ' s health.
Diabetes are to act on that body causes hypoinsulinism, insulin resistant etc. and a series of metabolism disorder syndromes such as the sugar that causes, protein, fat, power and water Xie Zhi by the various virulence factors such as inherited genetic factors, immunologic function disorder, classical symptom is mainly three-many-one-little symptom clinically, be polyuria, polydipsia, polyphagia and become thin, often occur multiple acute and chronic complication simultaneously.
Western medical treatment diabetes are mainly to promote the secretion of insulin to reach hypoglycemic object with medicine at present; Reduce glucose in the infiltration rate of enteral, increase the utilization of in-vivo tissue to glucose and promote the synthetic of hepatic glycogen, or direct injection exogenous insulin etc., hypoglycemic activity is quick and effect is strong, and can prevent and treat the acute and chronic complication of diabetes.But western medical treatment disadvantage is that effect is single, unidirectional, holds time short, and likely injures the internal organs such as Liver and kidney, and side effect is larger.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned defect, provides a kind of and treats that diabetes are rapid-action, the Chinese medicine composition of good effect and few side effects.
For addressing the above problem, the invention provides a kind of Chinese medicine composition that is used for the treatment of diabetes, the weight portion of said composition crude drug is:
Rhizoma Polygonati Odorati 10-20 gram, Fructus Ligustri Lucidi 10-20 gram, Oryza glutinosa 10-20 gram, Gypsum Fibrosum 10-20 gram, Radix Pseudostellariae 10-20 gram, Radix Aucklandiae 10-20 gram, Rhizoma Alismatis 5-10 gram, Herba Taraxaci 5-10 gram, Herba Dendrobii 5-10 gram.
As this kind of prioritization scheme:
Described prescription is the medicament that following raw material of Chinese medicine is made by weight ratio:
10 grams of Rhizoma Polygonati Odorati, 10 grams of Fructus Ligustri Lucidi, 10 grams, Oryza glutinosa, 10 grams, Gypsum Fibrosum, 10 grams of Radix Pseudostellariaes, 10 grams of the Radix Aucklandiae, 5 grams of Rhizoma Alismatis, 5 grams of Herba Taraxacis, 5 grams of Herba Dendrobiis.
As this kind of prioritization scheme:
Described prescription is the medicament that following raw material of Chinese medicine is made by weight ratio:
15 grams of Rhizoma Polygonati Odorati, 15 grams of Fructus Ligustri Lucidi, 15 grams, Oryza glutinosa, 15 grams, Gypsum Fibrosum, 15 grams of Radix Pseudostellariaes, 15 grams of the Radix Aucklandiae, 8 grams of Rhizoma Alismatis, 8 grams of Herba Taraxacis, 8 grams of Herba Dendrobiis.
As this kind of prioritization scheme:
Described prescription is the medicament that following raw material of Chinese medicine is made by weight ratio:
20 grams of Rhizoma Polygonati Odorati, 20 grams of Fructus Ligustri Lucidi, 20 grams, Oryza glutinosa, 20 grams, Gypsum Fibrosum, 20 grams of Radix Pseudostellariaes, 20 grams of the Radix Aucklandiae, 10 grams of Rhizoma Alismatis, 10 grams of Herba Taraxacis, 10 grams of Herba Dendrobiis.
Wherein: Rhizoma Polygonati Odorati sweet in the mouth greasiness, matter is soft and moisten, and YIN nourishing and the production of body fluid promoting is had to very large curative effect; It has very important regulating action to heart, blood pressure, blood glucose etc.There is blood sugar lowering simultaneously, adjust blood fat and lipoid peroxidization resistant, can obviously improve the glycolipid metabolism disorder of diabetes.The hyperglycemia that glucose, alloxan are caused also has inhibitory action.
Fructus Ligustri Lucidi mainly contains effects such as " yin nourishing gas, suppressing the hyperactive liver fire stop sweating due to debility, quench one's thirst ", energy liver and kidney tonifying, and clearind deficient heat, tomorrow, is mainly tonifying kidney-yin, realizes treatment and the control to diabetes by supplementing QI and nourishing YIN.According to modern pharmacological research, Fructus Ligustri Lucidi has hypoglycemic effect, and the blood sugar increasing that antagonism glucose causes, has preventive and therapeutic effect to diabetes.
Oryza glutinosa: have tonify deficiency, enrich blood, the effect such as spleen invigorating warming the stomach.Be applicable to regurgitation, poor appetite due to Deficiency and coldness of spleen and stomach, have loose bowels and the diseases such as unable, pregnant abdomen falling inflation of breathing hard that the deficiency of vital energy causes.There is astringent therapy effect, frequent micturition, spontaneous perspiration are had to good food therapy effect, in the present invention, mainly utilize the promoting blood circulation to remove obstruction in the collateral of Oryza glutinosa to realize treatment and the control to diabetes.
Gypsum Fibrosum acrid-sweet flavor, cold, there is clearing away heat-fire, relieving restlessness effect such as quench the thirst, can clearing away heat and promoting production of body fluid.The diseases such as the thirsty polydipsia that causes for diabetes clinically, polyphagia polyphagia, scorching inclined to one side victory, Gypsum Fibrosum can effectively get its heat and Tianjin from increasing, sugar falls thereupon, reaches therapeutic purposes.
Radix Pseudostellariae is called again Radix Ginseng, Tong Can, is the one of Radix Ginseng.The property of medicine is gentle, sweet in the mouth, has the effect of tonifying QI to produce body fluid.Be usually used in weakness of the spleen and stomach, the few expectorant of fatigue and weakness, inappetence, dry cough, after being ill body void, night sweat, night frightenedly cry, Infantile Summer Fever etc., Radix Pseudostellariae plays effect of Jiangtang Bushen in the present invention.Experimentation confirmation, Radix Pseudostellariae can improve immunologic function, improves cardiac function.Radix Pseudostellariae polysaccharide can improve the situation that diabetes occur, delays weight loss, reduces fasting glucose, reduces triglyceride (TG) and T-CHOL (TC) level, but does not affect insulin level, and diabetes are had to remarkable therapeutical effect.
Radix Aucklandiae acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian.In the water decoction of the Radix Aucklandiae, main active costunolide and dehydrocostuslactone have obvious hypoglycemic activity, possess antioxidation simultaneously, thereby effectively inhibited oxidation stress alleviate insulin resistant.
Rhizoma Alismatis property is sweet, cold, and effect is diuresis, clearing away damp-heat.For dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.Fatty contents in the water decoction of Rhizoma Alismatis has obvious cholesterol reducing effect and arteriosclerosis effect to Experimental Hyperlipemia hypercholesterolemia rabbit, by disturbing absorption, decomposition and the excretion of cholesterol, suppress the absorption of cholesterol and glycerol three fingers in food, affect the metabolism of body inner cholesterol, the hydrolysis of acceleration triglyceride or inhibition liver are synthetic to its, and performance reduces the effect of serum cholesterol, triglyceride.Be Rhizoma Alismatis can inducing diuresis for treating stranguria syndrome, clearing away heat and promoting production of body fluid, fundamentally treat diabetes.
The flat sweet and slightly bitter taste of Herba Taraxaci, can heat-clearing and toxic substances removing, and dispersing swelling and dissipating binds, has extraordinary effect for diuresis, and it has abundant vitamin A and C and mineral, the effect that dyspepsia, constipation are all improved.The flavone containing in the water decoction of Herba Taraxaci has a lot of biological activitys, blood fat reducing, blood sugar lowering, antibacterial, blood vessel dilating, function of gallbladder promoting hepatoprotective, anticancer etc., and especially rutin and Quercetin have the effect of remarkable inhibition acetylcholine esterase.
The yin nourishing of Herba Dendrobii function, clearing heat and moistening dryness, be exactly the medicine dedicated for the treatment of diabetes since ancient times, and it is Jiangtang Bushen effectively.Clinical research shows, the water decoction of Herba Dendrobii not only can strengthen insulin active, can significantly reduce blood sugar level simultaneously, makes blood sugar recovery normal.Diabetes basic pathogenesis is that the deficiency of YIN is scorching, internal organs are impaired.Herba Dendrobii is by nourishing the vital organs of the human body, and building body, strengthens immunity, generation that can complication prevention.In addition, dendrobine is that islets of langerhans supplements enough nutrition, activates rapidly insulin β cell, secrete a large amount of insulins, reduce blood glucose, the while receptor on active cell surface again, make the sugar in blood enter smoothly cell and be used, solve insulin resistant problem.
Diabetes spp is in Chinese medicine diabetes category, and head sees Huangdi's Internal Classics.The traditional Chinese medical science thinks, the factors such as eating and drinking without temperance, disorder of emotion, labor are wanted excessively, physical weakness all can be led diabetogenic generation.TCM treatment of diabetes is taking organic conception, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs as main, adopts and has clinically the blood sugar level of the controlled diabetes processed of many medicines, but have defect improving aspect diabetes " three-many-one-little " symptom.
The TCM treatment of diabetes experience of existing more than 2000 year, it is advantageous that entirety adjustment, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.The Therapeutic Principle such as equilibrium between yin and yang, integrally-regulated, supplementing QI and nourishing YIN, heat clearing and blood circulation promoting are focused in Chinese traditional treatment, adjust inside of human body environment, human endocrine metabolic function is played to dual regulation, can effectively improve patient's metabolism status, complication, and non-evident effect.But TCM treatment of diabetes is with clearly defined objective unlike doctor trained in Western medicine, how there is certain defect improving aspect diabetes " three-many-one-little " symptom.
Between every taste Chinese medicine in the present invention, by drawing after clinical prescription compatibility for several times, its manufacture method is simple, can be made into as required tablet, pill, the dosage form such as powder or oral liquid, after taking, medicine is totally started with from people's, treating both the principal and secondary aspects of a disease, wherein, Rhizoma Polygonati Odorati and Fructus Ligustri Lucidi supplementing QI and nourishing YIN, Oryza glutinosa promoting blood circulation to remove obstruction in the collateral, Gypsum Fibrosum, Rhizoma Alismatis can inducing diuresis for treating stranguria syndrome, clearing away heat and promoting production of body fluid, Radix Pseudostellariae, the Radix Aucklandiae, Herba Taraxaci and Herba Dendrobii, can Jiangtang Bushen, strengthen immunity and defying age ability, repair blood vessel comprehensively, neural, metabolism, the system pathological changes such as immunity, eliminate malaise, skin pruritus, numbness of hands and feet, blurred vision, insomnia, constipation, hypertension, hyperlipidemia, the various complication such as coronary heart disease.Because of the smart effect of distinctive yin nourishing benefit, often take three courses for the treatment of, each course for the treatment of 5-7 days, diabetics complication will correspondingly reduce, until make blood sugar recovery to normal condition.
Manufacture method of the present invention:
After above-mentioned Chinese medicine is mixed by weight, decoct with water 45 minutes, filtering medicinal residues, obtain oral liquid.Make after tablet, powder, pill or capsule can mix above-mentioned Chinese medicine by weight and be ground into end as need, make tablet, powder, pill or capsule.
Instructions of taking: every day potion, every day three times, bfore meals, within ten days, be a course for the treatment of.
The present invention is according to the pharmacology of above-mentioned Chinese medicine, and clinical trial for several times, to blue or green, in, old all ages and classes section gently, in, severe and neuropathy modification, tremulous pulse ischemic-type, mixed type diabetics all have obvious therapeutic effect.
For further investigating clinical efficacy and the safety of medicine of the present invention, we have selected 200 examples diabetics in various degree to carry out clinical trial to the treatment curative effect of medicine of the present invention.
200 routine diabeticss are divided into two groups at random, every group of 100 examples.In matched group, male's 62 examples, women's 38 examples; 30～40 years old age, 28 examples, 41～50 years old 32 example, 51～60 years old 24 example, 61～70 years old 14 example, 70 years old above 2 example; The course of disease 3 months to 3 years; In treatment group, male's 55 examples, women's 45 examples; 30～40 years old age, 18 examples, 41～50 years old 25 example, 51～60 years old 29 example, 61～70 years old 23 example, 70 years old above 5 example; The course of disease 4 months～4 years.
Two groups of cases, at aspect Epidemiological Analysis by statistics such as sex, age, the courses of disease, have comparability.All cases are all diagnosed with reference to the diagnostic criteria of diabetes in " internal medicine ".
Matched group adopts appropriate exercise, rational diet, and gourmet's luck gliclazide (diamicron, first sulphur adjoins the cheek), every day three times; The oral medicine of the present invention for the treatment of group is decocted rear oral administration solution, potion on the one, and each 500ml, three times on the one, treatment time is one month.
According to diabetes curative effect evaluation criteria:
Cure: transference cure, fasting glucose < 6.0mmol/L, (120mg/dl), 2 hours blood glucose < 6.3mmol/L (125mg/dl) after the meal, twenty-four-hour urine sugar total amount < 8.0g, or blood glucose, twenty-four-hour urine sugar total amount are treated front decline more than 50%.
Effective: after treatment, symptom disappears substantially, fasting glucose < 7.2mmol/L, (130mg/dl), 2 hours blood glucose < 8.3mmol/L (150mg/dl) after the meal, twenty-four-hour urine sugar total amount < 10.0g, or blood glucose, twenty-four-hour urine sugar total amount are treated front decline more than 30%.
Effective: after treatment, symptom is obviously improved, fasting glucose < 8.3mmol/L (150mg/dl), 2 hours blood glucose < 10.0mmol/L (180mg/dl) after the meal, twenty-four-hour urine sugar total amount < 25.0g, or blood glucose, twenty-four-hour urine sugar total amount are treated front decline more than 10%.
Invalid: after treatment, symptom is not improved, blood glucose, glucose in urine decline and do not reach above-mentioned standard.
Curative effect comparision result after two groups of case treatments is as table one.
Table one
| Group | Number of cases | Cure n (%) | Effective n (%) | Effectively n (%) | Invalid n (%) | Relapse rate n (%) |
| Matched group | 100 | 6(6.0) | 77(77.0) | 95(95) | 5(5) | 85(85) |
| Treatment group | 100 | 80(80.0) | 91(91) | 99(99) | 1(1) | 7(7) |
By above-mentioned contrast, not only the kind of required Chinese medicine is few can to find out prescription of the present invention, and cost is low, and therapeutic effect is remarkable, compared with taking Western medicine, aspect treatment diabetes, be all better than Western medicine, to cloudy disease, scorching, the diabetes cure rate of the five internal organs interior-deficiency is high, and total effective rate can reach 99%, in eliminating clinical symptoms, has also significantly reduced complication, really accomplishing takes stopgap measures effects a permanent cure, cure rate is high, good stability, and relapse rate is low.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine composition for the treatment of diabetes, choose 10 grams of Rhizoma Polygonati Odorati, 10 grams of Fructus Ligustri Lucidi, 10 grams, Oryza glutinosa, 10 grams, Gypsum Fibrosum, 10 grams of Radix Pseudostellariaes, 10 grams of the Radix Aucklandiae, 5 grams of Rhizoma Alismatis, 5 grams of Herba Taraxacis, 5 grams of Herba Dendrobiis, after mixing, decoct with water 45 minutes, filtering medicinal residues just obtain medicinal liquid, every day, potion, every day three times, bfore meals, within ten days, be a course for the treatment of, general three to five the course for the treatment of blood glucose just can recover normal.
Embodiment 2: a kind of Chinese medicine composition for the treatment of diabetes, choose 15 grams of Rhizoma Polygonati Odorati, 15 grams of Fructus Ligustri Lucidi, 15 grams, Oryza glutinosa, 15 grams, Gypsum Fibrosum, 15 grams of Radix Pseudostellariaes, 15 grams of the Radix Aucklandiae, 8 grams of Rhizoma Alismatis, 8 grams of Herba Taraxacis, 8 grams of Herba Dendrobiis, after mixing, decoct with water 45 minutes, filtering medicinal residues just obtain medicinal liquid, every day, potion, every day three times, bfore meals, within ten days, be a course for the treatment of, general four to six the course for the treatment of blood glucose can recover normal.
Embodiment 3: a kind of Chinese medicine composition for the treatment of diabetes, choose 20 grams of Rhizoma Polygonati Odorati, 20 grams of Fructus Ligustri Lucidi, 20 grams, Oryza glutinosa, 20 grams, Gypsum Fibrosum, 20 grams of Radix Pseudostellariaes, 20 grams of the Radix Aucklandiae, 10 grams of Rhizoma Alismatis, 10 grams of Herba Taraxacis, 10 grams of Herba Dendrobiis, after mixing, decoct with water 45 minutes, filtering medicinal residues just obtain medicinal liquid, every day, potion, every day three times, bfore meals, within five days, be a course for the treatment of, general five the course for the treatment of blood glucose can recover normal.
Some patients were healing case is as follows:
XX, man, 52 years old, suffer from diabetes more than ten years, long-term taking Western medicine, though can temporarily control, blood glucose is shakiness always, and has irregular pain when heart district, left side, with the symptom such as having a dizzy spell.Before taking prescription of the present invention, patient's fasting glucose > 9mmol/L, 2 hours blood glucose > 11mmol/L after the meal, twenty-four-hour urine sugar total amount > 26.0g, after taking 5 courses for the treatment of of prescription of the present invention, symptom is obviously improved, fasting glucose < 8.3mmol/L, 2 hours blood glucose < 10.0mmol/L after the meal, twenty-four-hour urine sugar total amount < 25.0g.
Lee XX, female, 63 years old, suffers from diabetes 5 years, take Western medicine, but blood glucose is always higher, twenty-four-hour urine sugar total amount is often closed on 28.0g always, after taking 3 courses for the treatment of of prescription of the present invention, blood glucose recovers normally gradually, continues to take to 64 courses for the treatment of, on an empty stomach and all obviously reductions of post-prandial glycemia index.
High mountain XX, man, 40 years old, suffer from diabetes 3 years, successively medical in this locality and People's Hospital of Weifang City etc. during one's sickness, take multi-medicament medicine, but blood glucose is always higher, fasting glucose often reaches 10.9mmol/L, and Gao Jing took after 2 courses for the treatment of of prescription of the present invention, blood glucose obviously improves, and twenty-four-hour urine sugar total amount is treated front decline more than 6%
Merchant XX, female, 65 years old, suffer from diabetes 12 years, successively taking during one's sickness multiple Western medicine and external insulin injection, although take effect for the moment, relapse rate is high, occurs the complication such as hypertension, cataract.Clinical diagnosis: fasting glucose is up to 11.2mmol/L, twenty-four-hour urine sugar total amount > 25.6g.Take after 8 courses for the treatment of of prescription of the present invention, blood glucose target effectively improves, and vision takes a turn for the better, and blood pressure is down to, and three-many-one-little symptom is obviously improved.
Claims (5)
1. a Chinese medicine composition for the treatment of diabetes, is characterized in that, described Chinese medicine composition is made up of the raw material of following weight portion:
Rhizoma Polygonati Odorati 10-20 gram, Fructus Ligustri Lucidi 10-20 gram, Oryza glutinosa 10-20 gram, Gypsum Fibrosum 10-20 gram, Radix Pseudostellariae 10-20 gram, Radix Aucklandiae 10-20 gram, Rhizoma Alismatis 5-10 gram, Herba Taraxaci 5-10 gram, Herba Dendrobii 5-10 gram.
2. Chinese medicine composition according to claim 1, is characterized in that: described prescription is the medicament that following raw material of Chinese medicine is made by weight ratio:
10 grams of Rhizoma Polygonati Odorati, 10 grams of Fructus Ligustri Lucidi, 10 grams, Oryza glutinosa, 10 grams, Gypsum Fibrosum, 10 grams of Radix Pseudostellariaes, 10 grams of the Radix Aucklandiae, 5 grams of Rhizoma Alismatis, 5 grams of Herba Taraxacis, 5 grams of Herba Dendrobiis.
3. Chinese medicine composition according to claim 1, is characterized in that: described prescription is the medicament that following raw material of Chinese medicine is made by weight ratio:
15 grams of Rhizoma Polygonati Odorati, 15 grams of Fructus Ligustri Lucidi, 15 grams, Oryza glutinosa, 15 grams, Gypsum Fibrosum, 15 grams of Radix Pseudostellariaes, 15 grams of the Radix Aucklandiae, 8 grams of Rhizoma Alismatis, 8 grams of Herba Taraxacis, 8 grams of Herba Dendrobiis.
4. Chinese medicine composition according to claim 1, is characterized in that: described prescription is the medicament that following raw material of Chinese medicine is made by weight ratio:
20 grams of Rhizoma Polygonati Odorati, 20 grams of Fructus Ligustri Lucidi, 20 grams, Oryza glutinosa, 15 grams, Gypsum Fibrosum, 15 grams of Radix Pseudostellariaes, 15 grams of the Radix Aucklandiae, 5 grams of Rhizoma Alismatis, 5 grams of Herba Taraxacis, 5 grams of Herba Dendrobiis.
5. Chinese medicine composition according to claim 1, is characterized in that: described prescription is the medicament that following raw material of Chinese medicine is made by weight ratio:
20 grams of Rhizoma Polygonati Odorati, 20 grams of Fructus Ligustri Lucidi, 20 grams, Oryza glutinosa, 20 grams, Gypsum Fibrosum, 20 grams of Radix Pseudostellariaes, 20 grams of the Radix Aucklandiae, 10 grams of Rhizoma Alismatis, 10 grams of Herba Taraxacis, 10 grams of Herba Dendrobiis.
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| CN106177507A (en) * | 2016-09-04 | 2016-12-07 | 佛山市顺德区宝铜金属科技有限公司 | The Chinese medicine composition for the treatment of diabetes and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106177507A (en) * | 2016-09-04 | 2016-12-07 | 佛山市顺德区宝铜金属科技有限公司 | The Chinese medicine composition for the treatment of diabetes and preparation method |
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