CN103736015A - Chinese medicinal preparation for treating virus B hepatitis and preparation method thereof - Google Patents

Abstract

The invention provides a Chinese medicinal preparation for treating virus B hepatitis. The preparation is prepared from the following bulk pharmaceuticals in parts by weight: 10-20 parts of chickenbone herb, 10-20 parts of spreading hedyotis herb, 10-20 parts of fortune eupatorium herb, 10-20 parts of fructus gardenia, 10-20 parts of Chinese thorowax root, 10-20 parts of virgate wormwood herb, 10-20 parts of oriental waterplantain rhizome, 10-20 parts of weeping forsythia, 10-20 parts of isatis root, 10-20 parts of Indian buead, 10-20 parts of common selfheal fruit-spike, 10-20 parts of Chinese magnoliavine fruit, 10-20 parts of immature bitter orange, 10-20 parts of large-head atractylodes rhizome, 10-20 parts of dogwood, 10-20 parts of glossy privet fruit, 10-20 parts of white paeony root, 10-20 parts of baikal skullcap root, 10-20 parts of turmeric root-tuber, 10-20 parts of purple perilla, 10-20 parts of szechwan Chinaberry fruit, 10-20 parts of curcuma zedoary and 10-20 parts of large-leaved gentian. The Chinese medicinal preparation has the effects of soothing the liver, regulating the qi, dispelling the stagnation, promoting blood circulation to dissipate stasis, benefiting qi, reinforcing deficiency, supporting the healthy energy, tonifying liver and kidney, clearing away heat and toxic materials, inducing diuresis, detoxifying, clearing away fire of liver, gallbladder and stomach, protecting liver, lowering transaminase, removing toxins and restoring the body immunity function to normal.

Description

A kind of Chinese medicine preparation for the treatment of hepatitis B and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of Chinese medicine preparation for the treatment of hepatitis B and preparation method thereof.

Background technology

Hepatitis B, is called for short hepatitis B, is a kind of by caused disease after hepatitis B virus (HBV) infection body.Hepatitis B virus is a kind of Hepadna Virus, is mainly present in hepatocyte and damages hepatocyte, causes hepatocyte inflammation, necrosis, fibrosis.Hepatitis B is divided acute and chronic two kinds.Acute hepatitis B 90% can spontaneous recovery in adult, and chronic hepatitis B performance differs, and is divided into HBV chronic carrier, chronic active hepatitis B, hbv-liver cirrhosis etc.The current hepatitis B virus carrying rate of China is 7.18%, and wherein approximately 1/3rd have hepatic injury repeatedly, shows as hepatitis B or the liver cirrhosis of activeness.The survey showed that for the prevalence of hepatitis B virus that China carried out in 2006, China 1-59 year crowd's hepatitis B surface antigen carrying rate is 7.18%, 5 years old following children's HBsAg carrying rate is only 0.96%, calculate accordingly, the existing Patients with Chronic HBV Infection of China approximately 9,300 ten thousand people, wherein have the activeness hepatitis B patient that symptom need to be treated to be about more than 2,000 ten thousand.

Hepatitis B is blood transmissible disease, main menses (as unsafe injection history etc.), mother-to-baby transmission and spread through sex intercourse, mucocutaneous damaged propagation also has certain proportion, as tatoo, Zha Erdong, splanchnoscopy etc., blood products is now strictly controlled, diffusibility greatly reduces, and just has generation during Blood and blood products transfusion lack of standardization.Accidental exposure in medical worker's work also can not be ignored.Along with Hepatitis B virus vaccine wideling popularize in neonate, and other mother and baby blocks the enforcement of measure, and mother-to-baby transmission is greatly controlled.HBV-DNA Positive Mothers childbirth at present approximately has 90 percent by intervening, successfully to block vertical transmission.HBV infects without respiratory tract, transmission, therefore daily study, work or life contact, as same office office appliances such as () shared computers, live a dormitory, same dining room together and have a dinner and embrace, shake hands, share lavatory etc. and can not infect HBV.Epidemiology and experimentation do not find that hepatitis B can be through hematophagus, as mosquito, bedbug bite are propagated.Age during hepatitis b virus infection is the main factor that causes hepatitis B chronicity, in perinatal stage (giving birth in 42 days to baby after being mother's pregnancy) and infantile period, infect in HBV, have respectively 90% and 25%～30% to develop into chronic infection, and with postoperative infection, only have 5%～10% to develop into chronic infection in 5 years old, infantile period becomes chb after infecting hepatitis B, its natural history is generally divided into 4 phases: i.e. immune tolerance, the immune clearance phase, inactive replicative phase and again active stage, each phase feature is: 1. immune tolerance: serum HBsAg, HBeAg, anti-HBC three's positive (being great three positive), HBV-DNA virus load is high, but liver function is normal, liver histological inspection has no obvious hepatic injury, this phase can maintain even many decades of several years.2. the immune clearance phase: this phase serum can be HBsAg, HBeAg, anti-HBC (great three positive), also can be HBsAg, anti-HBe, anti-HBC (small three positive), virus detection by quantitative (HBV-DNA) is generally greater than 2000IU/ml (being equivalent to 104copies/ml), with liver function abnormal (as ALT continues or intermittently raises) repeatedly, liver histological moderate or serious necrosis, hepatic fibrosis etc., repeatedly or serious hepatic injury can cause liver cirrhosis or liver failure.3. inactive replicative phase: show as HBsAg, anti-HBe, anti-HBC (small three positive), HBV-DNA is lower than detecting lower limit, liver function is normal, liver histological is harmless or have a slight infringement, this indicates that hepatitis B obtains the control of body immune system in body, and the risk that liver cirrhosis and hepatocarcinoma occur this phase patient greatly reduces.4. active stage again: hepatitis activity recurrence can again appear in some patient in nonmobile phase under some inducements, showing as DNA sun turns, abnormal liver function, aggravation etc., these inducements comprise fatigue, immunity degradation, use immunosuppressant or cytotoxic drug etc., especially still positive chronic hepatitis B patient of those " small three positive " but HBV-DNA, easily repeatedly occur hepatitis outbreak, progression of disease can develop into even HCC (primary hepatocarcinoma) of hepatic fibrosis, liver cirrhosis.

The feature of hepatitis B is that onset is more slow, more common with Subclinical and chronic type.Primary disease is mainly contacted and propagates with property by blood, mother and baby, is a kind of infectious disease with chronic carrier state.Its clinical manifestation variation, easily develops into chronic hepatitis and liver cirrhosis, and minority case also can change primary hepatoma into.The pathogenesis of hepatitis B is very complicated, and research data is many, but illustrates not yet completely so far.Think that at present its hepatocyte injury is not the result that HBV copies in hepatocyte, but mediated by T cytotoxic reaction.People infects after HBV, can cause cellular immunization and humoral immunoresponse(HI), and excites autoimmune response and immunoloregulation function disorder.The clinical manifestation of these immunoreation to hepatitis B and lapse to significant.

Acute hepatitis normally infects after HBV when immunologic function, and its cytotoxic T cell (Tc cell) is attacked the hepatocyte being contaminted, and is released into the HBV of blood by the hepatocyte of destroying, and by the combination of specific antibody institute, and interferon generates more, is eliminated and cause HBV, recovery from illness after all that sb.'s illness took a favorable turn.Chronic active hepatitis sees immunologic function defectiveness and immunoregulatory disorder person.Infect after HBV, because Tc cell function is undesired, or specific antibody enclosure portion liver cell target antigen and restrict T cytotoxic reaction, cause part of hepatocytes infringement.Interferon produces less, and HBV continues to copy.Specific antibody forms deficiency, and hepatocyte is invaded by HBV repeatedly, forms and infects chronicity.In addition, the special lipoprotein of liver plasma membrane (Lsp) forms autoantigen because HBV infects, stimulate B cell to produce anti-Lsp (IgG type), in suppressor T lymphocyte (Ts cell) activity decreased situation, autoimmunity ADCC effect causes hepatocyte progressive injury.Chronic persistent hepatitis and asymptomatic HBsAg carrier infecting HBV, can not produce effective immunoreation when body's immunity is low, cause hepatocellular damage slightly or do not occur hepatocellular damage.Especially asymptomatic HBeAg carrier, lacks interferon, can not remove virus, so that carries for a long time HBV.The generation of hepatitis gravis acute severe hepatitis, because organism immune response is excessively strong, T cytotoxic reaction in a short time destroys rapidly the hepatocyte of a large amount of HBV of infection; Or forming in a short time a large amount of antigen antibody complexs, activating complement, causes the local allergy (Arthus reaction) that occurs, and causes bulk hepatic necrosis; The endotoxic absorption of intestinal source property, can cause Schwartzman reaction, makes hepatocyte generation ischemic necrosis; In addition the cytokine such as α-tumornecrosisfactor (TNF-α), IL-1 and leukotriene is discharged by mononuclear phagocyte, promotes hepatocyte injury.Subacute severe hepatitis pathogenesis is similar to acute severe hepatitis, but progress is slower.The pathogenesis of chronic severe hepatitis is more complicated, needs further to be studied.Hepatitis B virus carriers be do not exist communicable.Acute viral hepatitis is cured above not yet as reached half a year, can develop into chronic hepatitis, there are part acute hepatitis B and hepatitis C patients, while making a definite diagnosis, are chronic hepatitis, heavy drinking, take the factors such as some drugs, some disease and also can cause chronic hepatitis.If do not taked, treat timely and effectively, easily cause nerve, psychiatric system, blood system, digestive system, heart damage, and causing the multiple diseases that have a strong impact on Health and Living such as primary hepatocellular carcinoma (hcc), myocarditis, aplastic anemia, clinical onset rate has the trend of continuous rising in recent years.

China is viral hepatitis big country, has more than 1.2 hundred million and carries for a long time hepatitis B virus (HBV), dies from every year HBV and infects relevant hepatopathy number approximately 280,000 examples.Viral hepatitis treatment is take antiviral as main, but commonly clinically in chronic course of disease progressive stage, occurs that jaundice do not move back lastingly, and severe patient causes liver cirrhosis, even liver failure, and stripping jaundice can delay the viral liver disease course of disease, improves life in patients.Jaundice eliminating drug main will comprise Western medicine at present: ursodesoxycholic acid, ademetionine, anethol trithione, motassium magnessium aspartate etc., but all because treatment cost is high, curative effect is not remarkable, and side effect is large, can not long-term taking.Chinese medicine has larger advantage in residual jaundice after treatment hepatitis.Clinical cheap in the urgent need to one, toxic and side effects is little, evident in efficacy, and the Chinese medicine preparation of energy long-term taking is treated chronic hepatitis B patient.

Summary of the invention

Technical problem to be solved by this invention is, treats the medicine of hepatitis B in prior art, is mostly to use Western medicine, and its toxic and side effects is large, and chemical composition is larger to human injury; Chinese medicine decoction is oral, although there are some curative effects, curative effect is not good enough, takes effect slow, and drug manufacture cost is higher, and the cycle is longer, so clinical, need a kind of cheap, toxic and side effects is little, evident in efficacy, and the Chinese medicine preparation of energy long-term taking is treated Subtype Patients with Hepatitis Virus B Infection.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of hepatitis B, in described Chinese medicine preparation, the parts by weight of various crude drug are: 10～20 parts of Herba Abris, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Herba Eupatoriis, 10～20 parts of Fructus Gardeniaes, 10～20 parts of Radix Bupleuri, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Rhizoma Alismatis, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Radix Isatidis, 10～20 parts, Poria, 10～20 parts of Spica Prunellaes, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Fructus Aurantii Immaturuss, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Corni, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Curcumaes, 10～20 parts of Folium Perillaes, 10～20 parts of Fructus Toosendans, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Gentianae Macrophyllae.

The Chinese medicine preparation of described treatment hepatitis B, described in it, in Chinese medicine preparation, the parts by weight of various crude drug can be: 10～15 parts of Herba Abris, 10～15 parts of Herba Hedyotidis Diffusaes, 10～15 parts of Herba Eupatoriis, 10～15 parts of Fructus Gardeniaes, 10～15 parts of Radix Bupleuri, 10～15 parts of Herba Artemisiae Scopariaes, 10～15 parts of Rhizoma Alismatis, 10～15 parts of Fructus Forsythiaes, 10～15 parts of Radix Isatidis, 10～15 parts, Poria, 10～15 parts of Spica Prunellaes, 10～15 parts of Fructus Schisandrae Chinensis, 10～20 parts of Fructus Aurantii Immaturuss, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Corni, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Curcumaes, 10～20 parts of Folium Perillaes, 10～20 parts of Fructus Toosendans, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Gentianae Macrophyllae.

The Chinese medicine preparation of described treatment hepatitis B, described in it, in Chinese medicine preparation, the parts by weight of various crude drug can also be: 10～20 parts of Herba Abris, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Herba Eupatoriis, 10～20 parts of Fructus Gardeniaes, 10～20 parts of Radix Bupleuri, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Rhizoma Alismatis, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Radix Isatidis, 10～20 parts, Poria, 10～20 parts of Spica Prunellaes, 10～20 parts of Fructus Schisandrae Chinensis, 10～15 parts of Fructus Aurantii Immaturuss, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Fructus Corni, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Curcumaes, 10～15 parts of Folium Perillaes, 10～15 parts of Fructus Toosendans, 10～15 parts of Rhizoma Curcumae, 10～15 parts of Radix Gentianae Macrophyllae.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine preparation for the treatment of hepatitis B, and the dosage form of described preparation is capsule, and its preparation process comprises:

A. described crude drug is put into pulverizer grinding and sieving;

B. coarse granule remaining after sieving is put into ethanol heating and refluxing extraction 2 times;

C. get again the medicinal residues after above-mentioned ethanol extraction, add water heating and refluxing extraction 2 times;

D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying are dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.

In described step a, described crude drug can be put into after pulverizer is pulverized and cross 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves standby.

In described step b, coarseparticulate remaining after sieving can be put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution be merged standing.

In described step c, the medicinal residues that above-mentioned ethanol extraction can be crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing.

In described steps d, above-mentioned two kinds of extracting solution can be merged to 1.35 filtrate when concentrating under reduced pressure relative density is 80 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 5kg/m ², hothouse hot stream temperature is 100 ℃, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and incapsulated with raw material medicated powder.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method of Chinese medicine preparation for the treatment of hepatitis B again, and the dosage form of described preparation is oral solutions, and its preparation process comprises: get above-mentioned raw materials medicine and clean roguing, dry, be ground into granule, soak 1 hour, put and in multi-function extractor, decoct with water secondary, add up for the first time the water of 10 times of amounts of medical material, decoct 1.5～2 hours, get decocting liquid, filter; Add up for the second time the water of 7 times of amounts of medical material, decoct 1～1.2 hour, get twice decocting liquid and mix, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Add the potassium sorbate that accounts for concentrated solution 0.2% again, then add water, stir, set to 0～5 ℃ of deepfreezes 24 hours, filter cold preservation liquid, and in potting bottle, ultraviolet disinfection, packs and get final product.

The Chinese medicine preparation of described treatment hepatitis B, its dosage form can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, suppository, plaster or cream

The technique effect that the present invention is useful is: energy depressed liver-energy dispersing and QI regulating resolving depression of the present invention; The evil poison of removing summer-heat, invigorating blood circulation addiction; QI invigorating tonify deficiency, strengthening the body resistance, the liver and the kidney tonifying; Liver and kidney tonifying.Advantage of the present invention is: 1, liver heat removing function of gallbladder promoting, diuresis toxin expelling, the fire of removing liver and gall stomach, activating blood circulation to dissipate blood stasis, invigorating spleen to remove dampness; 2, the liver protecting and ALT lowering, the evil poison of removing summer-heat, liver function recovery is normal, removes virus; 3, nourish the day after tomorrow, enhancing human body immunity function, promotes liver cell proliferation.The present invention treats hepatitis B, has good therapeutic effect, and medical expense is low, without obvious toxic-side effects.

The specific embodiment

The liver belonging to wood, main catharsis, the catharsis of hepatopathy mechanism of qi is unfavorable, will gram violate spleen soil, affects transformation and transportation of the spleen and stomach.And the spleen being the foundation of acquired constitution, source of generating QI and blood, the prosperous QI and blood foot of spleen, liver blood is full, contains and holds back liver-yang.Therefore should focus on nursing one's health Central Region, in case edema with the liver involved gram spleen.Be that < < Medical Treasures of the Golden Chamber > > says: see the disease of liver, knowing the liver disease will be transmitted into the spleen, in the ban tonifying the spleen.The spleen has the function to transport and transform nutrients, and water is wet, insufficiency of the spleen transformation failure of spleen, and retention of water-damp in the body, shows as abdominal distention loose stool clinically, fatigue and asthenia, extremity are slack, greasy fur etc.Syndrome Differentiation of Chinese Medicine about hepatitis B is controlled, and clinical report is a lot of, and the different rule treatments such as application supplementing QI and nourishing YIN, nourishing kidney easing the affected liver, removing pathogenic heat from blood and toxic substance from the body, dissipating phlegm and removing blood stasis all have certain effect.Chinese medicine thinks, chronic viral hepatitis B morbidity exopathogenic factor is epidemic disease caused by damp-heat pathogen poison, and endogenous cause of ill is disgruntled checking hyperfunction of the liver, and diet is (clean) joint not, causes visceral dysfunction, yang blood and qi loss.Damp and hot addiction resistance phlegm stagnancy is the source of primary disease, and visceral dysfunction is resembling of primary disease, and yang blood and qi weakness is basis of primary disease.Initial stage mostly is dampness-heat in the liver and gallbladder, stagnation of QI due to depression of the liver; See damp and hot middle Jiao that is detained mid-term, visceral dysfunction, forms stagnated QI transforming into fire, stagnation of liver-QI with deficiency of the spleen; Late period, healthy energy was injured, internal organs weakness, and negative and positive of qi and blood loss, forms the cloudy sound of Liver and kidney, deficiency of spleen-YANG and kidneyYANG, vital QI cannot conquer pathogen, human blood becomes trace.Primary disease is on the basis of violating at positive exogenous pathogen, to form damp and hot, the stagnation of QI, addiction blood, expectorant knot, and yang blood and qi virtual loss, affects the functions such as liver, gallbladder spleen, stomach, kidney.Whole nation viral hepatitis meeting is divided into syndrome of dampness-heat of liver and gallbladder, syndrome of stagnation of liver qi and spleen deficiency, syndrome of yin deficiency of liver and kidney, syndrome of yang deficiency of spleen and kidney and trace blood resistance network card totally five types by chronic hepatitis, except syndrome of dampness-heat of liver and gallbladder, in all the other pattern of syndrome, be all that, deficiency of qi and blood tired take stagnation of liver-QI with deficiency of the spleen, blood is basis, in syndrome, give priority to, therefore treatment is worked as take depressed liver-energy dispersing and QI regulating, invigorating blood circulation addiction, spleen invigorating the liver and the kidney tonifying as principle.

In theory of Chinese medical science, < < Medical Treasures of the Golden Chamber > > says: " yellow family gained, caused by pathogenic dampness ".It is wet that jaundice pathogenesis belongs to, and in the hepatitis later stage, damp major part is by Qinghua, and liver body is gradually multiple, but liver is with not fullying recover from an illness.Lose in catharsis, residual damp multiple abscess, in channels, is stopped up consor heat, therefore stagnant heat is not gone and still had residual Huang.Liver cirrhosis pathogen usually intruding into collateral in protracted disease, stagnant heat is not all right, easily makes humidogene heat, also has and stays for a long time the residual Huang not going, disease and the side of body rib feeling of distension and oppression pain of the dampness such as clinical visible mouth is sticky, yellowish urine, greasy fur, words are purple dark, the card of the not magnificent network stasis of blood of onyx.With the passing of time moist the moon is soft sticky, is difficult to speed clearly, evil stagnant, illegally occupies channels.Network is wet note, can not popular QI and blood, therefore coerce as seen rib feeling of distension and oppression pain, words are purple dark, the card that onyx is not magnificent.Dampness channels, gasifies not all right, therefore the dampness card of visible bitter taste, yellowish urine, greasy fur clinically of easily living again again.According to modern study, why hepatitis B virus can breed existence for a long time in human body, is mainly low with immune function of human body, can not remove due to virus.

Chronic viral hepatitis B belongs to the categories such as the traditional Chinese medical science " hypochondriac pain ", " jaundice ", " tympanites ".How, due to positive QI-insufficiency, in damp and hot malicious heresy, accumulate, the liver failing to maintain the normal flow of QI, with the passing of time injures due to spleen kidney.Therefore treatment chronic viral hepatitis B will be take reinforcing body resistance as main, heat-clearing and toxic substances removing, dampness, promoting flow of QI and blood are auxiliary, and note distinguishing cold and heat and asthenia and sthenia, reinforcement and elimination in combination.

In the present invention Herba Eupatorii QI invigorating consolidate, diuretic, promoting pus discharge and tissue regeneration strengthening; The Rhizoma Atractylodis Macrocephalae, Poria the spleen strengthening and damp drying; Radix Isatidis, Herba Hedyotidis Diffusae, Radix Scutellariae heat-clearing and toxic substances removing; Spica Prunellae blood circulation promoting and blood stasis dispelling, removing heat from blood; YIN nourishing and the production of body fluid promoting; Fructus Schisandrae Chinensis the kidney invigorating is promoted the production of body fluid; And can promote liver blood circulation, be beneficial to liver cell regeneration.Circulation of qi promoting that Radix Bupleuri is soothing the liver; Fructus Corni kidney invigorating and YANG supporting, in case too cold and cool; Herba Abri invigorating the spleen and benefiting QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, the merit that full side plays replenishing QI to invigorate the spleen dehumidifying, heat-clearing and toxic substances removing, promoting flow of QI and blood altogether, promoting blood circulation to remove obstruction in the collateral, the object of drive away blood poison to reach, recovering healthy energy.

Modern study is thought: Herba Eupatorii has enhancing human body immunity, increases human leukocyte inducing interferon and produces; The Rhizoma Atractylodis Macrocephalae can strengthen reticuloendothelial system phagocytic function, the liver protecting; Radix Scutellariae has enhancing leukocytic phagocytosis; The defense function of Fructus Schisandrae Chinensis energy enhancing body to nonspecific stimulation, has protective effect to hepar damnification, ultrastructure of hepatic cell is changed and obviously weaken, and also can make the ALT raising obviously reduce; Herba Abri can enhancing non-specific immunity function; Spica Prunellae grass has promotion liver cell regeneration, prevents hepatocellular degeneration effect.All medicines share, and can strengthen immune function of human body, reduce ALT, the liver protecting.All medicine synergism, make body's immunity recover normal, reach and remove virus, promote the object of rehabilitation.

Herba Abri: latin name Abrus cantoniensis, claim again Guangdong Semen Abri Precatorii, be a kind of plant of pulse family Abrus, be common in South China, the function of tool clearing away heat-damp and promoting diuresis, stomach reinforcing spleen invigorating.Clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.Main icterohepatitis, stomachache, rheumatic ostalgia, traumatic injury stasis of blood pain, mastalgia.< < book on Chinese herbal medicine pushes away old > > and says " have antipyretic diuresis, promoting blood circulation and stopping pain effect." we are equipped with Herba Eupatorii removing dampness by means of aromatics and are amusing, and medicine juice is convenient to into clothes, and except its abnormal flavour.We all have certain curative effect to acute, chronic hepatitis, cirrhotic ascites.But slightly cooler because of its property, insufficiency of the spleen cold syndrome of the stomach, often feels the patient of stomachache with cool feeling, chronic diarrhea, unsuitable long-term taking.

Fructus Toosendan is cold in nature, and bitter in the mouth is the one of qi-activating drug.Mainly enter Liver Channel, catharsis liver-heat, promoting the circulation of QI to relieve pain, have the function except damp and hot, clearing away liver-fire, pain relieving, parasite killing.Except damp and hot, clearing away liver-fire, pain relieving, parasite killing.Control epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.< < herbal classic > >: " main temperature disease, typhoid fever are too hot tired mad, kill three scabies and steal, diuresis water channel.″

Rhizoma Curcumae is pungent, bitter, temperature.Return liver, spleen channel.Cure mainly " lump in the abdomen, gathers for coagulation of QI-blood, trusted subordinate's distending pain, and dyspepsia does not disappear, women's blood stasis amenorrhea, and traumatic injury is had a pain." there are promoting QI circulation for relieving depression, removing blood stasis with potent drugs, the function of pain relieving.The mice alanine aminotransferase (ALT) that curcumenol extract and volatile oil cause carbon tetrachloride (CCI4) thioacetamide (TAA) raises obvious reducing effect, sulfobromophthalein sodium (BSP) retention amount is reduced, and corresponding liver tissue lesions alleviates.

Herba Eupatorii expelling summer-heat and damp, ward off dirty and in.Cure mainly and experience heat-damp in summer; Cold and heat headache; In moistening, accumulate; Gastral cavity painful abdominal mass is not hungry; Nausea and vomiting; Sweet greasy in mouthful; Disappear truly. < < Bencao Jingshu > >: lung governing qi, lung qi pent-up, upper orifices is closed and lower orifices are obstructed, the main Na Shuigu of stomach, stagnation of stomach-QI, water paddy not take time and as accumulation of phlegm in the hypochondrium, Herba Chlorophyti is pungent flat can eliminating stagnation stagnant, fragrance can be disliked by dirt eliminating, come up all cards from recover, mostly appetizing removes and dislikes, lung heat clearing expectorant, and the panacea of Disperse hepatic depression is also.< < key medicine is divided agent > >: Herba Chlorophyti, for expectorant is except the product of the Yu Xiejie that dislikes, falls apart, through the > > treating with Herba EuPatorii of quenching one's thirst, removing the accumulation of stale pathogen also in < <.Lid is quenched one's thirst by pathogenic heat pent-up in stomach, blue can removing the accumulation of stale pathogen.Known Herba Chlorophyti is solid to cleanse as merit, eliminates the intestines and stomach person also.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood.< < Japan hanako materia medica > >: control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, logical month water, brings down a fever, relieving restlessness, QI invigorating, the hot disease of it row, pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage, rush down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Fructus Forsythiae hardship, is slightly cold.Return lung, the heart, small intestine meridian.Function is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, pyretic stranguria urine retention.The medicinal part of Fructus Forsythiae is mainly fruit.Its shell, i.e. " sticking up " in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, Saponin, Citrin etc.There is the effects such as heat clearing away, removing toxic substances, eliminating stagnation evacuation of pus.Cure mainly warm, skin infection, scrofula, erysipelas, class's rash, influenza, be decocted in water for oral dose with fruit, or add in prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter in the mouth, cold nature.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Mongolian medicine bitter in the mouth, cool in nature." association day " clearly, antidiarrheal.Cure mainly: Chinese medicine is controlled calentura from the beginning of, anemopyretic cold, heating is vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.The mongolian medicine subcutaneous ulcer of harnessing the Yellow River, intestinal twinge, " association day " disease, intestinal heat.Sheng Nong's herbal classic > >: main cold and heat, Mus flaccidity, scrofula, carbuncle, malignant boil, goiter, stagnation of pathogenic heat, diseases due to noxious agents produced by various parasites.

The loose poison of Spica Prunellae heat clearing away, < < Compendium of Materia Medica > > carries " Spica Prunellae, is good at removing toxic substances, therefore control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Spica Prunellae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, that Spica Prunellae has is antibacterial, antiviral, antiinflammatory, antipyretic, regulate the effect traditional Chinese medical science such as immunity to think, Spica Prunellae is cold in nature, sweet in the mouth, gas are put down, and has the effect of heat-clearing and toxic substances removing, can treat the diseases such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.Spica Prunellae antipyretic and antidote functions is quite strong.Spica Prunellae can delay the pathological changes effect of Respirovirus to cell, is the representative medicine of heat-clearing and toxic substances removing, and pyretic toxicity essence is except containing multiple pathogenic microorganism, and microbial toxin also accounts for critical positions.Prunella spike lumbar injection can obviously reduce the leukocyte count of rabbit due to the endotoxin of bacillus pyocyaneus and decline, and deviation to the left phenomenon etc. has obvious antagonism.Poisoning symptom and death that Spica Prunellae compatibility Radix Scutellariae is prepared into preparation and can obviously alleviates bacillus pyocyaneus endotoxin caused rabbit.

Herba Hedyotidis Diffusae is again Herba Hedyotidis Diffusae, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia.Mildly bitter flavor, sweet, cold.Enter stomach, large intestine, small intestine meridian, clearing up internal heat by using drugs of bitter in taste and cold in nature removing toxic substances, sweet cold eliminating damp-heat, has stronger removing toxicity for eliminating carbuncles effect to carbuncle, pharyngalgia, snakebite etc.Be generally used for treatment sore, laryngopharynx swelling and pain, abdominalgia with intestinal abscess, venom, also for the puckery pain of pyretic stranguria, dysuria.The good medicine of damp eliminating of drawing out pus by applying a plaster to the affected part.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by Radix Scutellariae extracting solution effect.< < Bencao Jingshu > >: Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from by, source is clearly flowed also clean.The blood person of closing, excess-heat is at blood system, and amenorrhea is made us obstructed in instant heating human blood chamber, damp and hot solution, Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is stayed knot, and is that carbuncle stain is also rotten: acute scleritis person, fire of moxibustion blood trouble also, removing heat from blood heat extraction, spontaneous recovery also.Radix Scutellariae has antiallergic action and antiinflammatory action: the contained baicalin of Radix Scutellariae and baicalin can obviously suppress the anaphylaxis contractile response that sensitized guinea pig rat small intestine in vitro and isolated tracheal produce antigen, passive general allergy to Cavia porcellus and mice and Cavia porcellus passivity skin allergic reaction, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, most evidences, and the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has obvious Detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect of glucuronidase, and due to being combined with multiple poisonous substance.10 milligrams of LD50 that can improve strychnine of baicalin reach 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.

Radix Isatidis has antibiosis and antiviral functions: Radix Isatidis and activity extract thereof all have inhibitory action to hepatitis B virus, influenza virus, mumps virus, herpes simplex virus, hemorrahgic fever with renal syndrome virus, cytomegalovirus, Coxsackie virus etc.Radix Isatidis all has antibacterial action to multiple Gram-positive and negative bacteria, in addition leptospira is had to killing action.Radix Isatidis has anti-endotoxin effect: in the morbidity and evolution of acute infectious diseases, endotoxin has general impact, and test shows that Radix Isatidis endotoxemia mice macrophage membrane fluidity has extremely significant protective effect.Radix Isatidis also has antipyretic and antiinflammatory action.

Herba Artemisiae Scopariae cold nature, acrid in the mouth, painstaking effort can cure mainly clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus, infectious jaundice type hepatitis.The effect of Herba Artemisiae Scopariae.Clearing away heat-damp and promoting diuresis; Jaundice eliminating. cure mainly: jaundice; Dysuria; Eczema pruritus etc. pharmaceutical research has function of gallbladder promoting, and liver function protecting is antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating, certainly, this is that western medicine extracts the research that Herba Artemisiae Scopariae composition is worked it out, the how bad judgement of effect in clinical practice.Herba Artemisiae Scopariae consumption is excessive causes dizziness, feel sick, and diarrhoea, epigastric discomfort, acute Bile duct injury, but also there is ARR report. the Herba Artemisiae Scopariae of therapeutic dose generally can not caused serious damage.Herba Artemisiae Scopariae has significant hepatoprotective effect, to first, and hepatitis B, icterohepatitis, there is significant curative effect. there is function of gallbladder promoting, promote bile secretion, the effect that in increase bile, cholic acid and bilirubin are discharged. can increase heart coronary flow, improve microcirculation, and there is blood pressure lowering, blood fat reducing, anticoagulation, diuresis is antipyretic relievings asthma, and drives away ascarid and suppresses the effect of multiple pathogenic dermatophytes and antibacterial.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also there is remarkable inhibitory action.< < property of medicine opinion > > carries it: monarch, and sweet in the mouth, pungent, nontoxic.The main large migratory arthralgia of energy, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, under stopping, lets out.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in abdomen is vomited and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.

The Radix Curcumae resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.The resolving depression of regulating the flow of vital energy: for the breast side of body and the stomach abdominal distention and pain of depression of liver-QI.< < detailed outline > > carries it: the cold epidemic disease of loose seasonal epidemic pathogens, and sharp three warmers, separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in front puerperal.

Fructus Schisandrae Chinensis temperature; Sour, sweet; Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.Fruit is made Chinese medicine function supplementing QI for promoting the production of body fluid, the nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, is calmed the nerves, and can control the diseases such as chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, seminal emission chronic diarrhea, forgetful insomnia.Schisandra fruit implementation Chinese medicine function supplementing QI for promoting the production of body fluid, the nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, calm the nerves, can control the diseases such as chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, seminal emission chronic diarrhea, forgetful insomnia.Pharmacological testing proves to regulate central nervous system's excitement and process of inhibition, promotes body metabolism, regulates gastric juice and bile secretion, and hepatitis convalescent period transaminase rising person is had to reducing effect.< < book on Chinese herbal medicine converges says > >: Fructus Schisandrae Chinensis, the medicine that astringing QI promotes the production of body fluid also.Therefore the gas of the main convergence deficiency of the lung of < < Tang materia medica > > chronic cough dissipation.All deficiency of vital energy dyspnea with rapid respiration, cough with dyspnea strain, spirit is not enough, arteries and veins gesture inanition, or impairment caused by overstrain yang-energy, limbs are won thin, or empty gas is superior, and spontaneous perspiration comes frequently, or smart first exhaustion, and deficiency of YIN fire is scorching, or exhaustion of YIN YANG-depletion, refreshing scattered pulse is de-, with Fructus Schisandrae Chinensis, controls it, becomes to hold back and promote the production of body fluid with its acid guarantor's reinforcing premodial qi and without spermatorrhea also.So upper enter lung, be lowered to kidney, entering lung has the benefit of the Jiyuan of promoting the production of body fluid, entering kidney has controlling nocturnal emission with astringent drugs to support the merit of marrow.Cruel and the alcohol of Fructus Schisandrae Chinensis main component schizandrin, Fructus Schisandrae Chinensis, its mechanism of action is to suppress the vigor of transaminase in Hepatocyte, induced microparticle body produces cytochrome P-450, the detoxification ability of enhance hepatocyte, and can promote hepatocellular reparation

Fructus Ligustri Lucidi is for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to use, controls early whitening of beard and hair, often joins the same use of Fructus Mori, and fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.Protective effect research to liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, give rat skin lower injection, can reduce serum glutamic pyruvic transminase, the hepatic injury of Carbon Tetrachloride Induced being had to obvious protective effect, and can promote liver cell regeneration. oleanolic acid also can make in liver triglyceride accumulate that minimizings, hepatocellular degeneration necrosis obviously alleviate, glycogen is accumulated increase, serum γglobulin decline; Mitochondrial swelling and the degeneration of endoplasmic reticulum vesicle alleviates, the inflammatory reaction of hepatic tissue interstitial weakens in the visible hepatocyte of ultrastructure.

Radix Bupleuri clearind deficient heat Chinese medicine, for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus come off, menoxenia.Return Liver Channel, gallbladder meridian.Function: evacuate and bring down a fever, yang invigorating soothing liver-QI.Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.Treatment viral hepatitis: injection of Radix Bupleuri (every 1ml containing crude drug 2g) 10～20ml adds quiet of the quiet note of 50% Glucose Liquid or 5% Glucose Liquid 250～500ml, every day 1 time, was for 10 times 1 course for the treatment of, treatment viral hepatitis 120 examples, wherein acute case 97 examples, effective percentage is 98.4%; Chronic case 23 examples, effective percentage is 100%, to improving symptom, retraction liver spleen, recovery liver function and hepatitis B antigen negative conversion rate, all has better effect.

Poria sweet in the mouth, light, property are flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.But deficiency and coldness essence is sliding or collapse of QI person avoids clothes.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels due to insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Fructus Gardeniae is Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, is usually used in treating the diseases such as icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.Cure mainly calentura vexed; Liver-fire conjunctival congestion; Headache; Jaundice due to damp-heat; Stranguria; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.This product has very large curative effect to conjunctival congestion and swelling pain.These product rush down clearly three warmers pathogenic heat, and the conjunctival congestion and swelling pain of attacking on can treating the liver gallbladder burning hot, often joins Radix Et Rhizoma Rhei use, as Fructus Gardeniae soup < < Shengji Zonglu > >.

Rhizoma Alismatis (rhizome) is one of traditional Chinese medicine.Theory of Chinese medical science thinks that it is cold in nature, has the effect of promoting diuresis to eliminate damp pathogen.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma Alismatis and preparation modern times thereof are also used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.The fat-soluble part of Rhizoma Alismatis has obvious cholesterol reducing effect and study of anti-atherogenic effect to experimental hypercholesterolemicrabbits rabbit, by wherein separate Alisol A, B and Alisol A, the acetas of B, C, except alisol B, there is the cholesterol reducing effect showing.With 0.1% content, add in the feedstuff of experimental atherosclerosis rats, can make cholesterolemia decline more than 50%, wherein the strongest with the effect of Alisol A-24-acetas.The ethanol extraction of Rhizoma Alismatis, the ethyl acetate extract of ethanol extract etc., have effect for reducing blood fat to experimental hypercholesterolemicrabbits rabbit and rat.It is the strongest that ethyl acetate extract and its are insoluble to residual fraction effect in acetic acid one water.Ethyl acetate extract oral 1g/kg every day, also has obvious cholesterol reducing effect to raising with the normal rat of normal diet.Prove by coordination list notation method, Alisol A has the ability that suppresses mouse small intestine esterified cholesterol, and can make the absorbance of cholesterol in rat small intestine reduce by 34%, but does not affect linoleic absorption.

Folium Perillae expelling cold and relieving exterior syndrome, regulating the flow of QI to ease the stomach.Cure mainly cold, fever, be afraid of cold, lossless, uncomfortable in chest, cough, separates the poisoning stomachache causing of Eriocheir sinensis, diarrhoea, the diseases such as vomiting.Folium Perillae contains multiple nutritional components, is rich in especially carotene, vitamin C, B2.Abundant carotene, vitamin C contribute to increase by force immune function of human body, strengthen human body defending and fighting against diseases ability.Folium Perillae have deliver, cold expelling, the effect of regulating the flow of vital energy.This dish is applicable to the diseases such as cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen.Healthy People edible can building body, skin care, skin moistening, improving eyesight and fitness.

Fructus Corni, cures mainly pathogen cold and heat under the heart, and warming middle-JIAO, by cold warm numbness, goes three worms, the merit that for a long time clothes have been made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stopped dribbling urination; Take for a long time improving eyesight, brute force all the year round.Fructus Corni, has another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., is the conventional rare Chinese medicine of China, and applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties use that medical science is liked.Zhang Zhongjing has been formulated " JINGUI SHENQI WAN " take Fructus Corni as monarch.According to chemical analysis, Fructus Corni contains the effective ingredient such as cornin, tartaric acid, gallic acid, malic acid, resin, tannin and the multivitamin that physiologically active is stronger, having the immunity, antiinflammatory of enhancing, the pharmacological action such as antibacterial, is Herba indigoferae Pseudotinctoriae conventional in tcm clinical practice.

Fructus Aurantii Immaturus: hardship; Pungent; Cold.Return spleen; Stomach; Liver; Heart channel.Cure mainly: in stagnant, stop; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis; Uterine prolapse; Proctoptosis < < medicineization justice > > carries it: " Fructus Aurantii Immaturus is specially let out excess of the stomach; convince hard knot by patient analysis; therefore the main middle part of gastric cavity is to control blood system; treat the interventral reality of umbilicus full, expectorant addiction, dispels and cut off the water; by dyspepsia; broken blocked-up chest, and relieving constipation is closed, non-this can not be also.If skin pruritus, because of hematocele stagnant in, can not nutrition flesh table, if diet do not think, can not transporting because of spleen pent-up, all get power that its pungent loose hardship rushes down also.For the gas medicine in blood system, only this claims.”

Radix Gentianae Macrophyllae is Gentianaceae herbaceos perennial, is one of principal agent of the diseases such as dispelling the wind and dampness pathogens arthralgia, tuberculosis hectic fever, jaundice.Especially the Radix Gentianae Macrophyllae producing with Huang Nan in Qinghai is the best in quality.It is one of important Chinese medicine of China, begin to be loaded in < < Sheng Nong's herbal classic > >, classify middle product as, " the main cold and heat pathogen of Radix Gentianae Macrophyllae; cold-damp migratory arthralgia, arthrodynia of the extremities, Xia Shui, diuresis.”

The manufacturing process of the present invention's honey refining pill is: by Herba Abri 1000g, Herba Hedyotidis Diffusae 1000g, Herba Eupatorii 1000g, Fructus Gardeniae 1000g, Radix Bupleuri 1000g, Herba Artemisiae Scopariae 1000g, Rhizoma Alismatis 1000g, Fructus Forsythiae 1000g, Radix Isatidis 1000g, Poria 1000g, Spica Prunellae 1000g, Fructus Schisandrae Chinensis 1000g, Fructus Aurantii Immaturus 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Fructus Corni 1000g, Fructus Ligustri Lucidi 1000g, Radix Paeoniae Alba 1000g, Radix Scutellariae 1000g, Radix Curcumae 1000g, Folium Perillae 1000g, Fructus Toosendan 1000g, Rhizoma Curcumae 1000g, Radix Gentianae Macrophyllae 1000g, first described crude drug being dropped into multi-function extractor extracts twice, add for the first time 8-10 times of water gaging and decoct 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge decocting liquid twice, filter to get filtrate, heating is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven coolingly, grinds to form fine powder, calls in Mel and makes honey refining pill.

The manufacturing process of capsule of the present invention is: by Herba Abri 1500g, Herba Hedyotidis Diffusae 1500g, Herba Eupatorii 1500g, Fructus Gardeniae 1500g, Radix Bupleuri 1500g, Herba Artemisiae Scopariae 1500g, Rhizoma Alismatis 1500g, Fructus Forsythiae 1500g, Radix Isatidis 1500g, Poria 1500g, Spica Prunellae 1500g, Fructus Schisandrae Chinensis 1500g, Fructus Aurantii Immaturus 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Fructus Corni 1500g, Fructus Ligustri Lucidi 1500g, Radix Paeoniae Alba 1500g, Radix Scutellariae 1500g, Radix Curcumae 1500g, Folium Perillae 1500g, Fructus Toosendan 1500g, Rhizoma Curcumae 1500g, Radix Gentianae Macrophyllae 1500g, first described crude drug is put into after pulverizer is pulverized and crossed 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collect by the raw material fine powder of 120 mesh sieves standby.Particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing.The medicinal residues that above-mentioned ethanol extraction is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing, above-mentioned two kinds of extracting solution are merged, concentrating under reduced pressure relative density is the filtrate of 1.35 (80 ℃), reclaims ethanol, and gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of crossing spray dryer shower nozzle is 5kg/m ², hothouse hot stream temperature is 100 ℃, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and incapsulated with raw material medicated powder.Incapsulate and be made as capsule.

The preparation method of tablet of the present invention comprises: get Herba Abri 1500g, Herba Hedyotidis Diffusae 1500g, Herba Eupatorii 1500g, Fructus Gardeniae 1500g, Radix Bupleuri 1500g, Herba Artemisiae Scopariae 1500g, Rhizoma Alismatis 1500g, Fructus Forsythiae 1500g, Radix Isatidis 1500g, Poria 1500g, Spica Prunellae 1500g, Fructus Schisandrae Chinensis 1500g, Fructus Aurantii Immaturus 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Fructus Corni 1500g, Fructus Ligustri Lucidi 1500g, Radix Paeoniae Alba 1500g, Radix Scutellariae 1500g, Radix Curcumae 1500g, Folium Perillae 1500g, Fructus Toosendan 1500g, Rhizoma Curcumae 1500g, Radix Gentianae Macrophyllae 1500g, described component mixes by proportioning, drop into pulverizer and be ground into fine powder, after sieving, puts into fine powder acid and alkali-resistance infusion kettle, at normal temperatures, flood 10～20 days with ethanol is common, the liquid having flooded and medicinal residues are carried out to squeeze and filter, after separation, get filtrate, heating is concentrated into pasty state and adds starch mixing, put into baking oven, be controlled at 100 ℃, tabletting is made tablet.

The preparation method of oral solutions of the present invention comprises: get above-mentioned raw materials medicine Herba Abri 1000g, Herba Hedyotidis Diffusae 1000g, Herba Eupatorii 1000g, Fructus Gardeniae 1000g, Radix Bupleuri 1000g, Herba Artemisiae Scopariae 1000g, Rhizoma Alismatis 1000g, Fructus Forsythiae 1000g, Radix Isatidis 1000g, Poria 1000g, Spica Prunellae 1000g, Fructus Schisandrae Chinensis 1000g, Fructus Aurantii Immaturus 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Fructus Corni 1000g, Fructus Ligustri Lucidi 1000g, Radix Paeoniae Alba 1000g, Radix Scutellariae 1000g, Radix Curcumae 1000g, Folium Perillae 1000g, Fructus Toosendan 1000g, Rhizoma Curcumae 1000g, Radix Gentianae Macrophyllae 1000g; Clean roguing, dry, be ground into granule, soak 1 hour, put in multi-function extractor and decoct with water secondary, add up for the first time the water of 10 times of amounts of medical material, decoct 1.5～2 hours, get decocting liquid, filter; Add up for the second time the water of 7 times of amounts of medical material, decoct 1～1.2 hour, get twice decocting liquid and mix, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Add the potassium sorbate that accounts for concentrated solution 0.2% again, then add water, stir, set to 0～5 ℃ of deepfreezes 24 hours, filter cold preservation liquid, and in potting bottle, ultraviolet disinfection, packs and get final product.

Pharmacology's toxicity test

Acute toxicity testing data

Test example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: capsule of the present invention, containing 0.365g crude drug/grain.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, and 10 every group, male and female half and half, tablet adding distil water is dissolved, be made into Cmax, by the administration of the maximum permission capacity of mice, institute is followed successively by 18 to dosage by crude drug amount, 14.4,11.5,9.2,7.4 (g.kg ^-1), in animal fasting (can't help water) after 18 hours, administration at twice (interval half an hour) in a day, each 0.5ml, observes animal dead situation.

2, maximum tolerated dose is measured (MTD value): get 20 of mices, each 10 of male and female.Tablet adding distil water is dissolved, be made into maximum concentration, by the maximum tolerated dose of animal, to inject, fill with hello device and can twitch and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

LD50 calculate in when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, do not measure LD50, ask only maximum tolerated dose, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normally, there are no death.Select 300 times of doses that are equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: long term toxicity test data

Capsule of the present invention is through the gastric infusion long-term toxicity test for animals result of 6 months: SD rat is divided into three groups, 30 every group, male and female half and half (being divided into high, medium and low three dosage groups, 10 every group), wherein first group through gavage to normal saline; Second group is given dosage of the present invention through gavage is 0.25g, 2.5g and 12.5g/kg.d; The 3rd group is 0.5mg, 5.0mg and 50.0mg/kg.d through gavage to the dosage of lovastatin.During administration, observe respectively the indexs such as clinical manifestation, hematology, blood biochemistry, organ coefficient and histopathology after each treated animal administration and carry out the evaluation of drug toxicity.Result of study: main toxic reaction shows lovastatin 50mg/kg.d and 5.0mg group, shows after administration that reaction and the symptoms such as sialorrhea, hair are fluffy, busy, diarrhoea, step have appearred in SD rat, total food ration and losing weight; Blood test shows that total white blood cells increases to some extent, erythrocyte sum, content of hemoglobin and platelet count obviously decline (the equal < 0.05 of P); Blood biochemistry checking shows ALT, AST, ALP and 1～8 times (equal < 0.05 of P) of CK rising, and creatinine and blood urea nitrogen raise (the equal < 0.05 of P) to some extent, but do not cause animal dead; Histopathological analysis result shows that the Liver and kidney pathological change similar to people appearred in lovastatin 50mg/kg.d group.And all there is not similar reaction in tri-dosage groups of normal saline group and 0.25g of the present invention, 2.5g and 12.5g/kg.d and lovastatin 0.5mg/kg.d dosage group during whole administration, at convalescent period viewing duration, the symptom of each treated animal that the occurs reaction recovery normal condition that fades away.Visible the present invention not only can reduce the toxic and side effects of lovastatin, and can make the clinical non-toxic of lovastatin be increased to 5～25 times (the equal < 0.01 of P).

Test example 3: cumulative toxicity experiment:

Traditional Chinese medicine preparation capsule agent of the present invention to mice by 7.69,19.18 and 15 weeks (1.0ml/100g body weight of 43.21g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as the hair of Chinese medicine preparation of the present invention to rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 15 weeks and drug withdrawal are after 3 weeks, and the each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation oral capsule of the present invention is to rat long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Pharmacological experiment explanation:

1 experiment material

1.1 medicine

Positive control drug: liver heat removing capsule, Changchun Overseas Pharmaceutical Group Co, authentication code: the accurate word Z20050091 of traditional Chinese medicines.

1.2 animal Wistar rats, Kunming mouse, ♀ ♂ all uses.

2 impacts on ALT, ET, NO content in hepatic injury mice serum

2.1 groupings: get 105 kunming mices and be divided at random 6 groups, 15 every group, A group is Normal group; B group is model control group; C organizes positive matched group; D1 group is capsule of the present invention (embodiment is obtained) low dose group, and D2 group is dosage group in capsule of the present invention, and D3 group is capsule high dose group of the present invention;

2.2 modeling methods: adopt the method for bacillus calmette-guerin vaccine and lipopolysaccharide associating to set up immunological liver injury in mice model.Each treated animal adaptability is fed after 3d, except Normal group, and 1 tail vein injection bacillus calmette-guerin vaccine 5 × 10 of every mice ⁷individual viable bacteria, after injection of BCG, 12d intravenous injection lipopolysaccharide 7.5 μ g/ Mus are put to death and draw materials after 16h, and Normal group is all injected equivalent normal saline 2 times in the same way.

2.3 administrations and processing: the first day of intravenous injection bacillus calmette-guerin vaccine plays beginning gastric infusion, 1 time/d.Normal group and model control group: normal saline gavage, gavage amount is with the medication capacity of medication therapy groups; Positive control medicine treatment group: liver heat removing capsule, 5.9g/kg dosed administration; The low 3.9g/kg of medication therapy groups of the present invention, middle 7.8g/kg, high 11.7g/kg dosed administration.Normal group is 16h after 12d injecting normal saline, and eyeball rear vein beard is got blood, and puts to death animal and get hepatic tissue censorship; All the other groups are 16h after intravenous injection lipopolysaccharide, and eyeball rear vein beard is got blood, and puts to death animal and get hepatic tissue censorship.

2.4 observation index and detection method: 1. detect glutamate pyruvate transaminase (ALT): adopt chemical colorimetry to measure.2. endogenous nitric oxide (N0) is measured: adopt radioimmunology, cut open and get 0.5g liver and make 10% liver tissue homogenate, and under 4 ℃ of conditions, 3000 turn/min, centrifugal 10min, gets supernatant.3. Endothelin (ET) detects: adopt radiation to exempt from method and directly measure blood plasma ET concentration.

The situation of change comparison of the each group of table 1 Serum ALT, ET, N0

* with model group comparison, * P < 0.05, * * P < 0.01; Δ and positive controls comparison, Δ P < 0.05.

3, the protective effect to chronic hepatic injury

Rat skin lower injection 10%5ml/kg carbon tetrachloride oil solution, 2 times weekly, inject continuously 3 months, cause carbon tetrachloride chronic hepatic injury animal model, observe the protective effect of medicine of the present invention to damage liver.

Normal group and model control group: normal saline gavage, gavage amount is with the medication capacity of medication therapy groups; Positive control medicine treatment group: liver heat removing capsule, 2.7g/kg dosed administration; The present invention's (capsule) medication therapy groups, 2.7g/kg dosed administration.Normal group is 16h after 12d injecting normal saline, and eyeball rear vein beard is got blood, and puts to death animal and get hepatic tissue censorship; All the other groups are 16h after intravenous injection lipopolysaccharide, and eyeball rear vein beard is got blood, and puts to death animal and get hepatic tissue censorship.

The protective effect (X ± SD) of table 2 medicine of the present invention to chronic hepatic injury rat

* with model group comparison, * P < 0.05, * * P < 0.01; Δ and positive controls comparison, Δ P < 0.05.

As can be seen from the above results, detecting qualified medicine of the present invention has significance to improve to ALT, ET, N0 content in hepatic injury mice serum, and chronic hepatic injury is had to obvious protective effect, relatively has significant difference with positive control medicine.

Clinical trial

The clinical trial for the treatment of chronic type B viral hepatitis

One, diagnostic criteria

(1) Western medicine diagnose standard: prevent and treat scheme with reference to nineteen ninety-five Beijing whole nation infectious disease parasitic disease academic conference revision < < viral hepatitis) > > is about the diagnostic criteria of chronic type B viral hepatitis.

(2) tcm diagnosis standard:

1, traditional Chinese medical science disease: dampness network stasis of blood disease

2, dialectical standard: (1) xerostomia hardship is wish drink not; (2) association's rib feeling of distension and oppression pain; (3) onyx is not magnificent; (3) yellowish urine is just not well; (4) words are purple dark; Thin fur or greasy; (5) stringy pulse or carefully puckery.

Two, case inclusive criteria:

(1) clinical trial medication interior indagation in first 2 weeks meets above-mentioned " chronic viral hepatitis B " diagnostic criteria.(2) 1 week interior dialectical above-mentioned " dampness network stasis of blood disease " dialectical standard that meets of clinical trial medication.(3) ALT, AST < are normal below 3 times, 17.1umol/L < TBIL < 51.3umol/L.

(4) age 18-65 year.

(5) test is stopped using and was once adopted other Therapeutic Method for above-mentioned disease in first 2 weeks.

Three, case is rejected standard:

(1) in or 30 days, accept other clinical drug research.(2) patient that can not take medicine on request or be checked.(3) through checking the hepatitis (as drug intoxication, Alcoholic, autoimmunity and other non-hepatitis B etc.) that turns out to be other type.(4) the whole latter stage of serious anaphylaxis and chronic disease or disease.(5) women of gestation and age of sucking.(6) allly cannot judge that curative effect or data are incomplete, be discontented with 1 month person the course for the treatment of, and judgement and safety judgement person affect the treatment.

Four, test method and grouping:

1, method: adopt randomized controlled trial scheme.

2, case source and grouping:

This group case is all inpatient, wherein test group 50 examples, matched group 50 examples.

Five, control drug is selected: select function, cure mainly the ministry standard positive drug liver heat removing capsule substantially similar to this observation new drug.

Six, test medication:

1, observe medicine: the obtained capsule of the embodiment of the present invention, specification: 0.365g/ grain.

2, control drug: liver heat removing capsule, Changchun Overseas Pharmaceutical Group Co, authentication code: the accurate word Z20050091 of traditional Chinese medicines, specification: 0.25g/ grain.

Seven, Random Design: adopt table of random number method.

Eight, administrated method

Dosage: treatment group: 4 tablets/time of capsules of the present invention, every day twice, matched group: 4 tablets/time of liver heat removing capsules, every day twice, the course for the treatment of: 4-8 week.Route of administration: oral.4 weeks TBIL of medication still not descender can stop to change treatment.

Nine, observation item and index

1, safety indexes: respectively look into a kidney merit (BUN, Cr), ECG and blood, urine, feces routine before treatment and when treatment finishes.

2, before treatment and when treatment finishes, look into the ultrasound diagnosis of liver spleen color Doppler.

3, liver function (ALT, AST, TBIL, DBIL, A/G, PT/PA), the lab index such as hepatitis nosetiology are at least respectively looked into once before treatment and while finishing, but liver function can be according to state of an illness periodic review in therapeutic process.

Ten, curative effect

Curative effect determinate standard: with reference to " guideline of clinical investigations of new Chinese medicine treatment hepatitis B, curative effect determinate standard, point recovery from illness, effective, effectively, invalid.

1, recovery from illness: transference cure, skin, yellow sclera and sign disappear, and liver function recovery is normal, and serum total bilirubin is down to below 17umol/L.

2, effective: symptom is obviously improved, skin, yellow sclera and sign take a favorable turn, and serum total bilirubin is down to 17-25.5umol/L.

3, effective: symptom makes moderate progress, skin, yellow sclera and sign take a turn for the better, and serum total bilirubin is down to 25.6-34umol/L.

4, invalid: symptom is without improvement, sign, serum bilirubin are unchanged, even increase the weight of.

11, statistics are learned and are processed:

Adopt the X in SAS software data processing system ²date processing is carried out in check.

12, result:

1, selected number: treatment group 50 examples, matched group 50 examples, male's 32 examples in treatment group, women's 18 examples, 34.8 ± 13.5 years old mean age (18-55 year), matched group male 25 examples, female's 25 examples, 36.9 ± 11.7 years old mean age (19-57 year).Between the front group for the treatment of, state of an illness analysis of comparable is in Table 1

State of an illness distribution situation between table 1, two groups

Through X ²analyze, P > 0.05, treatment group and the matched group state of an illness be there was no significant difference relatively, has comparability.

2, efficacy analysis: total effects relative analysis is in Table 2

Total effects relative analysis situation between table 2, two groups

Through X ²analyze two groups of relatively P > 0.05 of total effects, total effects there was no significant difference compared with matched group for the treatment of group treatment chronic type B viral hepatitis.

The specific embodiment:

Embodiment 1: go into business certain, man, 38 years old, patient began to suffer from acute viral hepatitis (icteric) before 3 years, liver function obvious damage, because of a large amount of then secondary diabetes of input glucose, is in hospital nearly 2 years, and after leaving hospital, liver function fluctuates often, since nearly 1 month, liver function is obviously abnormal, examines front inspection: glutamate pyruvate transaminase 372U, the turbid 18U of Moschus moschiferous, fasting glucose 190mg%, glucose in urine (+++), dry mouth with bitter taste, yellowish urine, two side of body distending pains, time have an epistaxis, yellow fur, limit point is red, stringy and thready pulse.Take the present invention, side uses: Herba Abri 12g, Herba Hedyotidis Diffusae 11g, Herba Eupatorii 12g, Fructus Gardeniae 13g, Radix Bupleuri 12g, Herba Artemisiae Scopariae 13g, Rhizoma Alismatis 12g, Fructus Forsythiae 14g, Radix Isatidis 12g, Poria 11g, Spica Prunellae 12g, Fructus Schisandrae Chinensis 13g, Fructus Aurantii Immaturus 12g, Rhizoma Atractylodis Macrocephalae 12g, Fructus Corni 13g, Fructus Ligustri Lucidi 13g, Radix Paeoniae Alba 12g, Radix Scutellariae 11g, Radix Curcumae 12g, Folium Perillae 13g, Fructus Toosendan 14g, Rhizoma Curcumae 14g, Radix Gentianae Macrophyllae 14g, make capsule, every day 2 times, each 4, after 30 days, check liver function, glutamate pyruvate transaminase 120U, the turbid 6.5U of Moschus moschiferous, Moschus moschiferous wadding (-), cholesterolemia 154mg%, blood glucose 100rng%, glucose in urine (-), recover full-time job, continuous Chinese medicine preparation of the present invention 3 months that take, two side of body distending pains greatly alleviate, conscious good, diet is normal, can adhere to work, take again more than Chinese medicine preparation of the present invention March, symptom all disappears, liver function test: glutamate pyruvate transaminase is normal, Moschus moschiferous is turbid normal, Moschus moschiferous wadding (±), serum albumin/globulin is 4.3/2.7, blood glucose 155mg%, glucose in urine (-).

Embodiment 2: Feng, female, 26 years old.Before 3 years, found glutamate pyruvate transaminase 156U during registration physical examination, the turbid 7U of Moschus moschiferous, Moschus moschiferous wadding (++), be diagnosed as hepatitis, through " protecting the liver " treatment, do not heal always, before examining, look into: glutamate pyruvate transaminase 200U, the turbid 10U of Moschus moschiferous, Moschus moschiferous wadding (+++), patient's anorexia Mental fatigue, gastral cavity costalgia; yellow urine; xerostomia, red tongue with thin fur is greasy, thready and rapid pulse.Side uses: Herba Abri 14g, Herba Hedyotidis Diffusae 11g, Herba Eupatorii 12g, Fructus Gardeniae 13g, Radix Bupleuri 12g, Herba Artemisiae Scopariae 13g, Rhizoma Alismatis 12g, Fructus Forsythiae 14g, Radix Isatidis 12g, Poria 11g, Spica Prunellae 12g, Fructus Schisandrae Chinensis 12g, Fructus Aurantii Immaturus 12g, Rhizoma Atractylodis Macrocephalae 12g, Fructus Corni 13g, Fructus Ligustri Lucidi 13g, Radix Paeoniae Alba 12g, Radix Scutellariae 13g, Radix Curcumae 11g, Folium Perillae 13g, Fructus Toosendan 13g, Rhizoma Curcumae 11g, Radix Gentianae Macrophyllae 12g, make pill, take Chinese medicine preparation of the present invention 15 days, gastral cavity costalgia is day by day alleviated, spirit is gradually shaken, continuous Chinese medicine preparation of the present invention 1 month that takes, urine is normal, check: glutamate pyruvate transaminase 80U, the turbid 8U of Moschus moschiferous, Moschus moschiferous wadding (+), take again more than Chinese medicine preparation of the present invention February, check liver function recovers normal completely.

Embodiment 3: Zhang, man, 31 years old, good tobacco and wine, fatigue weak, hepatalgia is often felt in readme, gastral cavity is swollen abdominal distention, felt sick 2 months.Look into abnormal liver function: thymol turbidity test 12U, TFT (++), glutamate pyruvate transaminase is normal, HBsAg256U, its face is secretly sallow, and pulse condition stringy and thready pulse is slightly several.Make a definite diagnosis chronic hepatitis B.Side uses: Herba Abri 13g, Herba Hedyotidis Diffusae 12g, Herba Eupatorii 12g, Fructus Gardeniae 13g, Radix Bupleuri 12g, Herba Artemisiae Scopariae 13g, Rhizoma Alismatis 12g, Fructus Forsythiae 14g, Radix Isatidis 12g, Poria 11g, Spica Prunellae 12g, Fructus Schisandrae Chinensis 12g, Fructus Aurantii Immaturus 12g, Rhizoma Atractylodis Macrocephalae 12g, Fructus Corni 13g, Fructus Ligustri Lucidi 13g, Radix Paeoniae Alba 12g, Radix Scutellariae 13g, Radix Curcumae 11g, Folium Perillae 11g, Fructus Toosendan 12g, Rhizoma Curcumae 12g, Radix Gentianae Macrophyllae 13g, make oral solutions, take Chinese medicine preparation of the present invention 15 days, gastral cavity costalgia is day by day alleviated, spirit is gradually shaken, continuous Chinese medicine preparation of the present invention 1 month that takes, urine is normal, check: glutamate pyruvate transaminase 80U, the turbid 8U of Moschus moschiferous, Moschus moschiferous wadding (+), take again more than Chinese medicine preparation of the present invention March, check liver function recovers normal completely.

Claims (10)

1. treat the Chinese medicine preparation of hepatitis B for one kind, it is characterized in that, described Chinese medicine preparation comprises the crude drug of following parts by weight: 10～20 parts of Herba Abris, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Herba Eupatoriis, 10～20 parts of Fructus Gardeniaes, 10～20 parts of Radix Bupleuri, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Rhizoma Alismatis, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Radix Isatidis, 10～20 parts, Poria, 10～20 parts of Spica Prunellaes, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Fructus Aurantii Immaturuss, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Corni, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Curcumaes, 10～20 parts of Folium Perillaes, 10～20 parts of Fructus Toosendans, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Gentianae Macrophyllae.

2. treat according to claim 1 the Chinese medicine preparation of hepatitis B, it is characterized in that, in described Chinese medicine preparation, the parts by weight of various crude drug are: 10～15 parts of Herba Abris, 10～15 parts of Herba Hedyotidis Diffusaes, 10～15 parts of Herba Eupatoriis, 10～15 parts of Fructus Gardeniaes, 10～15 parts of Radix Bupleuri, 10～15 parts of Herba Artemisiae Scopariaes, 10～15 parts of Rhizoma Alismatis, 10～15 parts of Fructus Forsythiaes, 10～15 parts of Radix Isatidis, 10～15 parts, Poria, 10～15 parts of Spica Prunellaes, 10～15 parts of Fructus Schisandrae Chinensis, 10～20 parts of Fructus Aurantii Immaturuss, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Corni, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Curcumaes, 10～20 parts of Folium Perillaes, 10～20 parts of Fructus Toosendans, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Gentianae Macrophyllae.

3. treat according to claim 1 the Chinese medicine preparation of hepatitis B, it is characterized in that, in described Chinese medicine preparation, the parts by weight of various crude drug are: 10～20 parts of Herba Abris, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Herba Eupatoriis, 10～20 parts of Fructus Gardeniaes, 10～20 parts of Radix Bupleuri, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Rhizoma Alismatis, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Radix Isatidis, 10～20 parts, Poria, 10～20 parts of Spica Prunellaes, 10～20 parts of Fructus Schisandrae Chinensis, 10～15 parts of Fructus Aurantii Immaturuss, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Fructus Corni, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Curcumaes, 10～15 parts of Folium Perillaes, 10～15 parts of Fructus Toosendans, 10～15 parts of Rhizoma Curcumae, 10～15 parts of Radix Gentianae Macrophyllae.

4. a preparation method for the treatment of the Chinese medicine preparation of hepatitis B as described in any one in claim 1～3, is characterized in that, the dosage form of described preparation is capsule, and its preparation process comprises:

A. described crude drug is put into pulverizer grinding and sieving;

B. coarse granule remaining after sieving is put into ethanol heating and refluxing extraction 2 times;

C. get again the medicinal residues after above-mentioned ethanol extraction, add water heating and refluxing extraction 2 times;

D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying are dry, obtain medicated powder; The raw material fine powder that mixing sieves obtains incapsulates and is made as capsule.

5. treat according to claim 4 the preparation method of hepatitis B capsule, it is characterized in that, in described step a, described crude drug is put into after pulverizer is pulverized and crossed 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves standby.

6. the preparation method for the treatment of according to claim 4 hepatitis B capsule, is characterized in that, in described step b, coarseparticulate remaining after sieving is put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution is merged standing.

7. the preparation method for the treatment of according to claim 4 hepatitis B capsule, is characterized in that, in described step c, the medicinal residues that above-mentioned ethanol extraction is crossed add water heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution is merged standing.

8. treat according to claim 4 the preparation method of hepatitis B capsule, it is characterized in that, in described steps d, above-mentioned two kinds of extracting solution are merged, 1.35 filtrate when concentrating under reduced pressure relative density is 80 ℃, reclaims ethanol, and gained filtrate is adjusted to proportion to 1.60, pass into spray dryer and spray dryly, the compressed air pressure of crossing spray dryer shower nozzle is 5kg/m ², hothouse hot stream temperature is 100 ℃, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and incapsulated with raw material medicated powder.

9. as described in any one in claim 1～3, treat the preparation method of the Chinese medicine preparation of hepatitis B for one kind, it is characterized in that, the dosage form of described preparation is that the preparation process of oral solutions comprises: get above-mentioned raw materials medicine and clean roguing, dry, be ground into granule, soak 1 hour, put and in multi-function extractor, decoct with water secondary; Add up for the first time the water of 10 times of amounts of medical material weight, decoct 1.5～2 hours, get decocting liquid, filter; Add up for the second time the water of 7 times of amounts of medical material weight, decoct 1～1.2 hour, get twice decocting liquid and mix, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Add the potassium sorbate that accounts for concentrated solution 0.2% again, then add water, stir, set to 0～5 ℃ of deepfreezes 24 hours, filter cold preservation liquid, and in potting bottle, ultraviolet disinfection, packs and get final product.

10. according to the Chinese medicine preparation for the treatment of hepatitis B described in claim 1～9, it is characterized in that, the dosage form of described Chinese medicine preparation is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, pill, powder, sublimed preparation, injection, suppository, plaster or cream.