CN103356964A

CN103356964A - Medicament for treating ovarian cyst, and preparation method thereof

Info

Publication number: CN103356964A
Application number: CN2013103178745A
Authority: CN
Inventors: 张佳奇
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-07-26
Filing date: 2013-07-26
Publication date: 2013-10-23
Anticipated expiration: 2033-07-26
Also published as: CN103356964B

Abstract

The invention discloses a medicament for treating ovarian cyst, and a preparation method thereof. The medicament is prepared by peach seed, sinapis alba, laminaria japonica aresch, radix astragali, salvia miltiorrhiza, licorice, cassia twig and orange peel according to a certain weight ratio. The medicament has the functions of removing heat, cooling blood, regulating vital energy, alleviating depression, clearing channels, activating collaterals, warming interior and dispersing cold, and has the advantages of being fast in effectiveness, good in curative effect and high in cure rate when used to treat ovarian cyst.

Description

A kind of medicine for the treatment of ovarian cyst and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of ovarian cyst and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Ovarian cyst refers to the benign tumor of ovary, is one of modal gynaecopathia.Can betide any female age, take period of duration as common.How the common non-evident sympton of patient chances on when having a medical check-up.PD is slower clinically, with the slow increase of cyst, the performances such as menoxenia, abdominal distention stomachache is often arranged.If ovarian cyst generation torsion of pedicle then has severe stomachache abdominal distention, dyspnea, appetite depression, feels sick and generates heat etc.After cyst increases gradually, can lay one's hand on and lump in hypogastric region.The thinner cyst of cyst wall under external force can spontaneous breaking, causes the acute situations such as acute pain, breach be hemorrhage, but even threat to life.Larger cyst can cause compressing near internal organs bladder, rectum, the ureter etc., causes frequent micturition, the difficult defecation of urinating, and intestinal obstruction can appear in severe patient, and urine retention, hydronephrosis cause the pathological changes that kidney is more serious then.When these symptoms were more serious, the probability that the women suffers from ovarian cyst was higher, and the pernicious probability of suffering from ovarian cancer of pathological changes and harm are just larger.At present, because Western medicine can't effectively treat ovarian cyst, and the long-term taking Western medicine has more side effect, and therefore, there is very large demand in people to the Chinese medicine of effective treatment ovarian cyst.

Summary of the invention

The inventor has finally found the medicine of effective treatment ovarian cyst, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.

Purpose of the present invention just provides a kind of composition of medicine that can effectively treat ovarian cyst.

Another object of the present invention has just provided the preparation method of this composition of medicine.

Medicine of the present invention selects Semen Persicae, Semen Sinapis Albae, Thallus Laminariae (Thallus Eckloniae), the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Ramulus Cinnamomi, Pericarpium Citri tangerinae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Spica Prunellae, Poria, Rhizoma Cyperi, Semen Persicae, Retinervus Luffae Fructus, Cortex Cinnamomi, Oletum Trogopterori, Rhizoma Curcumae medicine to make up, with these drug regimens so that each efficacy of drugs produces synergism, thereby recurrence that can fast treating ovarian cyst.Wherein select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, blood stasis removing and clots absorbing is arranged, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Semen Sinapis Albae to be because its nature and flavor are hot, temperature enters lung, stomach warp, and the promoting the circulation of QI eliminating phlegm is arranged, warming spleen and stomach for dispelling cold, and the function of removing obstruction in the collateral to relieve pain is controlled the phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, the regurgitation vomiting, aphasia due to apoplexy, the limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Select Thallus Laminariae (Thallus Eckloniae) to be because its nature and flavor are salty, cold, enter the stomach warp, softening the hard mass is arranged, the function of row water is controlled scrofula, and goiter is dysphagic, edema, painful and swollen testis, leukorrhagia.Select the Radix Astragali to be because its nature and flavor are sweet, tepor enters lung, spleen channel, give birth to the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting is controlled spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and hold back for a long time; Process with the function that the invigorating middle warmer benefit is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor enters the heart, Liver Channel, and blood circulation and promoting silt is arranged, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving is controlled angina cordis, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, the overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle is given birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Selecting Ramulus Cinnamomi is that temperature enters bladder, the heart, lung meridian, and the diaphoresis expelling pathogenic factors from muscles is arranged because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation is controlled exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select Pericarpium Citri tangerinae to be because its nature and flavor are arduous, temperature enters spleen, lung meridian, regulate the flow of vital energy, and in the accent, dampness, the function of reducing phlegm is controlled distension and fullness of the chest and abdomen, anorexia, vomiting hiccup, cough with copious phlegm.Selecting Radix Angelicae Sinensis is that temperature enters the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation because of the sweet suffering of its nature and flavor, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after the bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Rhizoma Chuanxiong to be because its nature and flavor are hot, temperature enters liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, and the function of promoting blood circulation and stopping pain is controlled air-cooled headache and is revolved dizzyly, and the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, clearing away heat and cooling blood is arranged, the function of eliminating stasis to stop pain is controlled warm poison and is gone mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass stomachache, injury from falling down, carbuncle skin infection.Select Spica Prunellae to be because its nature and flavor toil is cold, enter liver, gallbladder meridian, liver heat removing is arranged, the function of eliminating stagnation is controlled scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia is shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming is controlled dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Rhizoma Cyperi to be because the hot little hard work of its nature and flavor is flat, enter liver, tri-jiao channel, the resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Select Retinervus Luffae Fructus to be because its nature and flavor are sweet, flat, dredge the meridian passage is arranged, the function of removing heat-phlegm is controlled pain in chest and hypochondrium, stomachache, lumbago, painful and swollen testis, lung-heat productive cough, women's amenorrhea, galactostasis, carbuncle, anal fistula.Selecting Cortex Cinnamomi is that heat enters kidney, spleen, urinary bladder channel because of its property acrid-sweet flavor, the complement sun is arranged, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation is controlled decline of the fire from the gate of life, the cold extremities faint pulse, and the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Selecting Oletum Trogopterori is that temperature enters liver, spleen channel because of its property bitter but sweet flavor, gives birth to the function that the promoting the circulation of blood pain relieving is arranged, and controls all pains of trusted subordinate's vim and vigour, women's amenorrhea, and postnatal blood stasis is had a pain; External treatment Serpentis, scorpion, centipete bite are fried with hemostasis, control metrorrhagia, menorrhagia, and leucorrhea with bloody discharge is without cease.Select Rhizoma Curcumae to be because its nature and flavor are hot, bitter, temperature is returned liver, spleen channel, and the circulation of qi promoting removing blood stasis is arranged, the function ， Zhi mass in the abdomen mass in the abdomen of removing food stagnancy pain relieving, blood stasis amenorrhea, food stagnation anus pain, treating swelling and pain by traumatic injury, early cervical carcinoma.

The specific embodiment

The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope

Semen Persicae 8-15 gram Semen Sinapis Albaes 10-20 gram Thallus Laminariae (Thallus Eckloniae)s 10-20 grams

The Radix Astragali 8-15 gram Radix Salviae Miltiorrhizaes 10-20 gram Radix Glycyrrhizaes 10-20 grams

Ramulus Cinnamomi 8-15 gram Pericarpium Citri tangerinaes 10-20 gram Radix Angelicae Sinensis 15-25 grams

Rhizoma Chuanxiong 15-25 gram Radix Paeoniae Rubra 10-20 gram Spica Prunellaes 15-25 grams

Poria 10-20 gram Rhizoma Cyperis 8-15 gram Retinervus Luffae Fructuss 10-20 grams

Cortex Cinnamomi 8-15 gram Oletum Trogopteroris 8-15 gram Rhizoma Curcumae 10-20 grams

Preferable amount is

Semen Persicae 10 gram Semen Sinapis Albaes 15 gram Thallus Laminariae (Thallus Eckloniae)s 15 grams

The Radix Astragali 10 gram Radix Salviae Miltiorrhizaes 15 gram Radix Glycyrrhizaes 15 grams

Ramulus Cinnamomi 10 gram Pericarpium Citri tangerinaes 15 gram Radix Angelicae Sinensis 20 grams

Rhizoma Chuanxiong 20 gram Radix Paeoniae Rubra 15 gram Spica Prunellaes 20 grams

Poria 15 gram Rhizoma Cyperis 10 gram Retinervus Luffae Fructuss 15 grams

Cortex Cinnamomi 10 gram Oletum Trogopteroris 10 gram Rhizoma Curcumae 15 grams

The preparation method of medicine of the present invention is as follows

One, gets the raw materials ready

1, Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;

2, Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, little have fragrance and get final product;

3, Thallus Laminariae (Thallus Eckloniae): choose decontamination, water rinses, and is cut into wide silk, dries;

4, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

5, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

6, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, airing;

7, Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening is cut into slices to thoroughly, dries, and sieves anti-dandruff;

8, Pericarpium Citri tangerinae: brush away earth, choose clean impurity, the spray clear water, shredding or section are dried behind the moistening;

9, Radix Angelicae Sinensis: choose decontamination, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;

10, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;

11, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping is cleaned, runs through, and shave, drying, sieve removes chip;

12, Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;

13, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

14, Rhizoma Cyperi: choose decontamination, be ground into particle, winnow with a dustpan fine, soft fur and smalls;

15, Retinervus Luffae Fructus: clean and dry cutting;

16, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, infiltrates a moment with warm water, and section is dried;

17, Oletum Trogopterori: choose clean impurity, smash or sieve the dedust bits;

18, Rhizoma Curcumae: get crude drug, remove impurity, big or small stepping is cleaned, and slightly soaks, and takes out, runs through, and shave, drying, sieve removes chip.

Two, preparation

1, Semen Persicae, Semen Sinapis Albae, Thallus Laminariae (Thallus Eckloniae), the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Ramulus Cinnamomi, Pericarpium Citri tangerinae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Spica Prunellae, Poria, Rhizoma Cyperi, Retinervus Luffae Fructus, Cortex Cinnamomi, Oletum Trogopterori, the Rhizoma Curcumae medicine with described weight decocts with water secondary, for the first time adding 6 times of water gagings soaks, soak after 180 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 25 minutes, and filtered to get decoction liquor for the first time.

2, the medicinal residues that filter are added 4 times of amounts of water, intense fire decocts boiling 15 minutes, uses slow fire boiling 15 minutes again, filters to get decoction liquor for the second time.

3, twice decoction liquor merged, intense fire boils, and simmers in water 15 minutes again, decoction liquor is divided into 6 doses takes.

Medicine of the present invention has clearing away heat and cooling blood, the resolving depression of regulating the flow of vital energy, and dredge the meridian passage, removing obstruction in the collateral to relieve pain, the effect of warming spleen and stomach for dispelling cold, treatment ovarian cyst instant effect, short treating period do not recur.

Below further set forth the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 40 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 20 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day 2 times, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 150 examples for medical treatment, 20-30 year 53 examples, 31-40 year 49 examples, 41-50 year 27 examples, 21 examples more than 50 years old.

2, diagnostic criteria

Clinical manifestation: the most incidental ovarian cyst of women of childbearing age is the ovarian function cyst, such as follicular cyst, corpus lutein cyst, leuteivic cyst, polycystic ovary, this is because due to the excessive physiological that endocrine dysfunction imbalance, lutropin hyposecretion, medicine irritation etc. cause reacts.The patient is generally without any sensation or uncomfortable, and a few peoples may have menoxenia, dysmenorrhea, sterile etc., the unexpected discovery during how because of other reason medical check.

Struvite ovarian cyst is because salpingitis tubal ordinary wave and ovary form inflammatory effusion, empyema, closely forms ovarian cyst.Say that exactly it should be inflammatory mass, and be not true gamogenetic egg nest cyst.Miscarriage or puerperium medical history are arranged, heating, lower abdominal pain are often arranged, the unusual discharge opeing of vagina, leucorrhea abnormal and flavor is arranged.

Chocolate cyst of ovary has another name called ovarian endometrial cyst, also is comparatively common ovarian cyst.Be because endometriosis involves ovary, in ovary, form the cyst of chocolate-like thick liquid.Dysmenorrhea, sexual anhedonia, infertile and menoxenia that carrying out property of patient Chang You increases the weight of.

Ovarian cyst in early days may not can symptom occur, but major part is to find when gynecologial examination.The symptom that can occur is as follows: the conscious abdominal circumference of patient increases, and can touch and lower abdomen has enclosed mass, and outstanding morning is clear when suppressing urine, may disappear again after urinating.Frequent micturition can appear in lumbago, abdominal distention once in a while, but without dysurea, urgent micturition, or constipation is arranged.Such as ovarian cyst generation torsion of pedicle, break etc., show as acute abdominal pain, be clinical medical common acute abdomen.

3, Therapeutic Method

Select above-mentioned medicament, take to the patient, each serving with 1 dose, every day early, middle and late respectively the clothes 1 time, 15 days is a course for the treatment of, takes continuously 4 courses for the treatment of.

4, efficacy assessment standard

Produce effects: ovarian cyst is eliminated, and observes after half a year without recurrence;

Take a turn for the better: the ovarian cyst symptom is clearly better;

Invalid: symptom does not reach improvement standard person without improvement.

5, therapeutic outcome

In above-mentioned treatment, with Drug therapy ovarian cyst patient 140 examples of the present invention, produce effects 140 examples as a result, obvious effective rate is 93.33%, 7 examples that take a turn for the better, improvement rate is 4.67%, invalid 3 examples, total effective rate is 98%.

Claims

1. medicine for the treatment of ovarian cyst, it is characterized in that: it is to be made by the crude drug in the following weight range:

Cortex Cinnamomi 8-15 gram Oletum Trogopteroris 8-15 gram Rhizoma Curcumae 10-20 grams.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Poria 15 gram Rhizoma Cyperis 10 gram Retinervus Luffae Fructuss 15 grams

Cortex Cinnamomi 10 gram Oletum Trogopteroris 10 gram Rhizoma Curcumae 15 grams.

3. the preparation method of described medicine according to claim 1 and 2, it comprises the following steps:

(1) gets the raw materials ready

(1) Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;

(2) Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, little have fragrance and get final product;

(3) Thallus Laminariae (Thallus Eckloniae): choose decontamination, water rinses, and is cut into wide silk, dries;

(4) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

(5) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

(6) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, airing;

(7) Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening is cut into slices to thoroughly, dries, and sieves anti-dandruff;

(8) Pericarpium Citri tangerinae: brush away earth, choose clean impurity, the spray clear water, shredding or section are dried behind the moistening;

(9) Radix Angelicae Sinensis: choose decontamination, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;

(10) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;

(11) Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping is cleaned, runs through, and shave, drying, sieve removes chip;

(12) Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;

(13) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

(14) Rhizoma Cyperi: choose decontamination, be ground into particle, winnow with a dustpan fine, soft fur and smalls;

(15) Retinervus Luffae Fructus: clean and dry cutting;

(16) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, infiltrates a moment with warm water, and section is dried;

(17) Oletum Trogopterori: choose clean impurity, smash or sieve the dedust bits;

(18) Rhizoma Curcumae: get crude drug, remove impurity, big or small stepping is cleaned, and slightly soaks, and takes out, runs through, and shave, drying, sieve removes chip;

(2) preparation

(1) Semen Persicae, Semen Sinapis Albae, Thallus Laminariae (Thallus Eckloniae), the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Ramulus Cinnamomi, Pericarpium Citri tangerinae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Spica Prunellae, Poria, Rhizoma Cyperi, Retinervus Luffae Fructus, Cortex Cinnamomi, Oletum Trogopterori, the Rhizoma Curcumae medicine with described weight decocts with water secondary, for the first time adding 6 times of water gagings soaks, soak after 180 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 25 minutes, and filtered to get decoction liquor for the first time;

(2) medicinal residues that filter are added 4 times of amounts of water, intense fire decocts boiling 15 minutes, uses slow fire boiling 15 minutes again, filters to get decoction liquor for the second time;

(3) twice decoction liquor merged, intense fire boils, and simmers in water 15 minutes again, decoction liquor is divided into 6 doses takes.