CN104352758A - Medicine for treating hypertension and preparation method thereof - Google Patents

Medicine for treating hypertension and preparation method thereof Download PDF

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Publication number
CN104352758A
CN104352758A CN201410703844.2A CN201410703844A CN104352758A CN 104352758 A CN104352758 A CN 104352758A CN 201410703844 A CN201410703844 A CN 201410703844A CN 104352758 A CN104352758 A CN 104352758A
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radix
semen
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侯德润
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侯德润
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533Leonurus (motherwort)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536Prunella or Brunella (selfheal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/13Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a medicine for treating hypertension and a preparation method thereof. The medicine is mainly prepared from folium mori, chrysanthemum, semen cassiae, radix puerariae, fructus crataegi, black sesame, herba leonuri, selfheal, radix salviae miltiorrhizae, radix achyranthis bidentatae and the root bark of white mulberry according to a certain weight ratio. The medicine disclosed by the invention has the functions of invigorating splenic yang, relieving muscles, soothing nerves, promoting blood circulation, removing stasis, dispelling wind and arresting convulsion, is used for treating the hypertension and short in course of treatment, becomes effective rapidly and causes no toxic or side effects.

Description

One treats hypertensive medicine and preparation method thereof
Technical field
The present invention relates to one and treat hypertensive medicine and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Hypertension is a kind of clinical common syndrome increased based on systemic arterial blood pressure, and be also the topmost high-risk disease of cardiovascular and cerebrovascular disease, apoplexy, myocardial infarction, heart failure and chronic kidney disease are its major complications.Prevalence of Hypertension increases with the age and raises; Women's prevalence before climacteric, a little less than male, but to raise rapidly, even higher than male after climacteric; High latitude cold district prevalence is higher than the warm area of low latitudes, and high altitude localities is higher than low altitude area; Relevant with dietary habit, salt and saturated fat are taken in higher, and mean blood pressure level and prevalence are also higher.Population of China hypertension is popular has two to compare outstanding feature: from south to the north, Prevalence of Hypertension is increasing trend; At present, western medicine antihypertensive effect is not good, and long-term taking Western medicine has more side effect, therefore, and the demand that people are very large to effectively treatment hypertensive Chinese medicine existence.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the effectively hypertensive medicine for the treatment of, thus completes the present invention.
Object of the present invention is just to provide one can effectively treat hypertensive composition of medicine.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Folium Mori, Flos Chrysanthemi, Semen Cassiae, Radix Puerariae, Fructus Crataegi, Semen Sesami Nigrum, Herba Leonuri, Spica Prunellae, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Cortex Mori, Rhizoma Cyperi, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Herba Taxilli, Semen Plantaginis, Ramulus Uncariae Cum Uncis, Lumbricus, Cortex Eucommiae medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus can effectively treat hypertensive recurrence.Wherein select Folium Mori to be because its property bitter but sweet flavor, cold, enter lung, Liver Channel, have expelling wind and clearing away heat, the function of cooling blood for improving eyesight, dispelling the wind and dampness pathogens generates heat, headache, and conjunctival congestion is thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.Flos Chrysanthemi is selected to be that cool, enter lung, Liver Channel, have dispelling wind, disappear heat, improving eyesight, and the function of removing toxic substances, controls headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling because its nature and flavor sweetness and bitterness.Semen Cassiae is selected to be because its property bitter but sweet flavor, cool, enter liver, kidney channel, have liver heat removing, improving eyesight, diuretic, the function of relieving constipation, control wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, liver cirrhosis abdomen, habitual constipation.Select Radix Puerariae to be that flat, enter spleen, stomach warp, have yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, the function that relieving restlessness is only drunk, cure the wound cold, cure the wound cold, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery because its nature and flavor are sweet pungent, skin eruption is not saturating, hypertension, and angina pectoris is deaf.Select Fructus Crataegi be because its nature and flavor acid sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function, controls meat Ji , mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate.Semen Sesami Nigrum is selected to be because its nature and flavor are sweet, flat, return liver, kidney, large intestine channel, have invigorating the liver and kidney, benefiting essence-blood, the function that intestine moistening is dry, control and feel dizzy, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.Select Herba Leonuri to be that cool, enter pericardium, Liver Channel, invigorate blood circulation, blood stasis dispelling, regulating menstruation, the function of the water that disappears, controls menoxenia because its nature and flavor are worked hard, control and Lou have difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Select Spica Prunellae to be because its nature and flavor toil, cold, enter liver, gallbladder meridian, have liver heat removing, the function of eliminating stagnation, controls scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia is shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.Radix Salviae Miltiorrhizae is selected to be that tepor, enters the heart, Liver Channel, have blood circulation and promoting silt, calming heart and tranquilizing mind, evacuation of pus, and the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, and to close, metrorrhagia leukorrhagia , mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia because its nature and flavor are bitter, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid, flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea , mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury, ripe invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Select Cortex Mori to be that cold, enter lung, spleen channel, have eliminating pathogen from the lung for relieving asthma, the function of line water detumescence, controls dyspnea and cough due to lung-heat because its nature and flavor are sweet, spit blood, edema, beriberi, dysuria.Rhizoma Cyperi is selected to be because the pungent micro-hard work of its nature and flavor, flat, enter liver, tri-jiao channel, resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Select Radix Ophiopogonis to be because its property sweet and slightly bitter taste, cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, and the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, and clearly yearningly, calentura Tianjin is hindered, dry mouth and throat, constipation.Radix Et Rhizoma Rhei is selected to be that enter stomach, large intestine, liver footpath, have the poison that purges heat, removing mass is stagnant because its nature and flavor are bitter, cold, the function of clots absorbing blood, control excess-heat constipation, delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi , lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Select Herba Taxilli to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive function, controls soreness of waist and knee joint, and muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Semen Plantaginis is selected to be that cold, enter kidney, urinary bladder channel, have diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, and arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view because its nature and flavor are sweet.Select Ramulus Uncariae Cum Uncis to be because its nature and flavor are bitter, cool, enter liver, heart channel, have heat clearing away suppressing the hyperactive liver, the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., controls little Jing Epilepsy Chi Zong, adult's slight Hypertension, dizzy, dizzy, married woman's eclampsia.Lumbricus is selected to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, have heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control high fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select the Cortex Eucommiae be because its nature and flavor sweet micro-pungent, temperature, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, antiabortive function, control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, hypertension.
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight:
Folium Mori 20-25 grams of Flos Chrysanthemis 20-25 grams of Semen Cassiaes 10-15 grams
Radix Puerariae 10-15 Keshan short, bristly hair or beard 10-15 grams of Semen Sesami Nigrums 10-15 grams
Herba Leonuri 10-15 grams of Spica Prunellaes 15-20 grams of Radix Salviae Miltiorrhizaes 15-20 grams
Radix Achyranthis Bidentatae 15-20 grams of Cortex Mori 15-20 grams of Rhizoma Cyperis 15-20 grams
Radix Ophiopogonis 15-20 grams of Radix Et Rhizoma Rhei 5-8 grams of Herba Taxillis 5-8 grams
Semen Plantaginis 5-8 grams of Ramulus Uncariae Cum Uncis 5-8 grams of Lumbricuss 5-8 grams
The Cortex Eucommiae 5-8 grams
Preferable amount is:
Folium Mori 23 grams of Flos Chrysanthemis 23 grams of Semen Cassiaes 13 grams
Radix Puerariae 13 Keshan short, bristly hair or beard 13 grams of Semen Sesami Nigrums 13 grams
Herba Leonuri 13 grams of Spica Prunellaes 17 grams of Radix Salviae Miltiorrhizaes 17 grams
Radix Achyranthis Bidentatae 17 grams of Cortex Mori 17 grams of Rhizoma Cyperis 17 grams
Radix Ophiopogonis 17 grams of Radix Et Rhizoma Rhei 6 grams of Herba Taxillis 6 grams
Semen Plantaginis 6 grams of Ramulus Uncariae Cum Uncis 6 grams of Lumbricuss 6 grams
The Cortex Eucommiae 6 grams
The preparation method of medicine of the present invention is as follows:
One, get the raw materials ready
1, Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;
2, Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;
3, Semen Cassiae: get clean Semen Cassiae, putting in pot to fry has fragrance to micro-, takes out, cools;
4, Radix Puerariae: pick decontamination, cleans, is soaked in water, pulls out, run through, cut into slices in time, dry;
5, Fructus Crataegi: pick clean impurity, sieve enucleation;
6, Semen Sesami Nigrum: get crude drug, removing impurity, sieve removes chip;
7, Herba Leonuri: pick decontamination, cleans, runs through, cutting, dry;
8, Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;
9, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
10, Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;
11, Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;
12, fry Rhizoma Cyperi: the Rhizoma Cyperi of pulverizing is put into cylinder, mixes thoroughly with yellow wine and rice vinegar, then add water with Saccharum Sinensis Roxb. and fry melt in right amount, then Rhizoma Cyperi is poured in pot, fully mix fried dry with Saccharum Sinensis Roxb. water, every Rhizoma Cyperi grain 100 jin, with each 20 jin of yellow wine, rice vinegar, Saccharum Sinensis Roxb. 6 jin.
13, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;
14, Radix Et Rhizoma Rhei: pick clean impurity, size stepping, stews to moisten to inside and outside humidity even, cuts into slices or is cut into small pieces, dries;
15, Herba Taxilli: wash, runs through, and cutting is dried;
16, Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
17, Ramulus Uncariae Cum Uncis: pick old stalk, impurity, cleans, dries;
18, Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;
19, the Cortex Eucommiae: removing rough bark, clean, run through, dice or strand, dry.
Two, prepare
1, by the Folium Mori of described weight, Flos Chrysanthemi, Semen Cassiae, Radix Puerariae, Fructus Crataegi, Semen Sesami Nigrum, Herba Leonuri, Spica Prunellae, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Cortex Mori, stir-fry Rhizoma Cyperi, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Herba Taxilli, Semen Plantaginis, Ramulus Uncariae Cum Uncis, Lumbricus, Cortex Eucommiae medicine, decoct with water secondary, add water 6 times amount for the first time, soak after 90 minutes, intense fire decocts boiling 10 minutes, again with slow fire boiling within 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.
2, by filtering medicinal residues add water 4 times amount, first boiling with high heat, then using slow fire boiling 30 minutes, second time decoction liquor is poured in container.
3, twice decoction liquor is carried out mixing and stirring, obtain medicinal liquid, medicinal liquid is divided into 3 doses and takes.
The present invention selects Radix Salviae Miltiorrhizae to be monarch drug, and Ramulus Uncariae Cum Uncis, the Cortex Eucommiae are ministerial drug, and Semen Cassiae is assistant, and said medicine and all medicines, for making, are combined the medicine made and treat renal calculus by Spica Prunellae.
Medicine of the present invention has yang invigorating expelling pathogenic factors from muscles, calming heart and tranquilizing mind, blood circulation promoting and blood stasis dispelling, and the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., is used for the treatment of hypertension, short treating period, instant effect, non-relapse after healing, has no side effect.
Detailed description of the invention:
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] hypertension therapy of the present invention:
1, physical data
Accept out-patient's totally 38 examples for medical treatment.
2, diagnostic criteria
Clinical manifestation: hypertensive symptom varies with each individual.Early stage possibility is asymptomatic or symptom is not obvious, blood pressure only can occur after fatigue, psychentonia, anxious state of mind and raise, and recover normal after rest.Along with the course of disease extends, blood pressure significantly continues to raise, and there will be various symptom gradually.Now be called as benign hypertension.Benign hypertension common clinical symptoms has headache, dizziness, absent minded, hypomnesis, numb limbs and tense tendons, nocturia increase, cardiopalmus, uncomfortable in chest, weak etc.Even there will be severe headache, vomiting, cardiopalmus, the symptom such as dizzy when blood pressure is elevated to a certain degree suddenly, time serious, obnubilation, tic can occur.This just belongs to accelerated hypertension and hypertension critical illness, how infringement and the pathological changes of the organs such as the serious heart, brain, kidney can occur in a short time, as apoplexy, heart infarction, renal failure etc.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 10 days, is a course for the treatment of, takes 6 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: transference cure, blood pressure recovers normal, observes half a year without recidivist;
Take a turn for the better: symptom is clearly better, headache, vertigo symptoms alleviates, and nocturia reduces, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by hypertension therapy patient 38 example of the present invention, effective 29 examples of result, obvious effective rate is 76.31%, and take a turn for the better 6 examples, and improvement rate is 15.8%, and invalid 3 examples, total effective rate is 92.11%.

Claims (3)

1. treat a hypertensive medicine, it is characterized in that: it is made up of the crude drug in following weight range:
Folium Mori 20-25 grams of Flos Chrysanthemis 20-25 grams of Semen Cassiaes 10-15 grams
Radix Puerariae 10-15 Keshan short, bristly hair or beard 10-15 grams of Semen Sesami Nigrums 10-15 grams
Herba Leonuri 10-15 grams of Spica Prunellaes 15-20 grams of Radix Salviae Miltiorrhizaes 15-20 grams
Radix Achyranthis Bidentatae 15-20 grams of Cortex Mori 15-20 grams of Rhizoma Cyperis 15-20 grams
Radix Ophiopogonis 15-20 grams of Radix Et Rhizoma Rhei 5-8 grams of Herba Taxillis 5-8 grams
Semen Plantaginis 5-8 grams of Ramulus Uncariae Cum Uncis 5-8 grams of Lumbricuss 5-8 grams
The Cortex Eucommiae 5-8 grams.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Folium Mori 23 grams of Flos Chrysanthemis 23 grams of Semen Cassiaes 13 grams
Radix Puerariae 13 Keshan short, bristly hair or beard 13 grams of Semen Sesami Nigrums 13 grams
Herba Leonuri 13 grams of Spica Prunellaes 17 grams of Radix Salviae Miltiorrhizaes 17 grams
Radix Achyranthis Bidentatae 17 grams of Cortex Mori 17 grams of Rhizoma Cyperis 17 grams
Radix Ophiopogonis 17 grams of Radix Et Rhizoma Rhei 6 grams of Herba Taxillis 6 grams
Semen Plantaginis 6 grams of Ramulus Uncariae Cum Uncis 6 grams of Lumbricuss 6 grams
The Cortex Eucommiae 6 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
One, get the raw materials ready
1, Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;
2, Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;
3, Semen Cassiae: get clean Semen Cassiae, putting in pot to fry has fragrance to micro-, takes out, cools;
4, Radix Puerariae: pick decontamination, cleans, is soaked in water, pulls out, run through, cut into slices in time, dry;
5, Fructus Crataegi: pick clean impurity, sieve enucleation;
6, Semen Sesami Nigrum: get crude drug, removing impurity, sieve removes chip;
7, Herba Leonuri: pick decontamination, cleans, runs through, cutting, dry;
8, Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;
9, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
10, Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;
11, Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;
12, fry Rhizoma Cyperi: the Rhizoma Cyperi of pulverizing is put into cylinder, mixes thoroughly with yellow wine and rice vinegar, then add water with Saccharum Sinensis Roxb. and fry melt in right amount, then Rhizoma Cyperi is poured in pot, fully mix fried dry with Saccharum Sinensis Roxb. water, every Rhizoma Cyperi grain 100 jin, with each 20 jin of yellow wine, rice vinegar, Saccharum Sinensis Roxb. 6 jin;
13, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;
14, Radix Et Rhizoma Rhei: pick clean impurity, size stepping, stews to moisten to inside and outside humidity even, cuts into slices or is cut into small pieces, dries;
15, Herba Taxilli: wash, runs through, and cutting is dried;
16, Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
17, Ramulus Uncariae Cum Uncis: pick old stalk, impurity, cleans, dries;
18, Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;
19, the Cortex Eucommiae: removing rough bark, clean, run through, dice or strand, dry,
Two, prepare
1, by the Folium Mori of described weight, Flos Chrysanthemi, Semen Cassiae, Radix Puerariae, Fructus Crataegi, Semen Sesami Nigrum, Herba Leonuri, Spica Prunellae, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Cortex Mori, stir-fry Rhizoma Cyperi, Radix Ophiopogonis, Radix Et Rhizoma Rhei, Herba Taxilli, Semen Plantaginis, Ramulus Uncariae Cum Uncis, Lumbricus, Cortex Eucommiae medicine, decoct with water secondary, add water 6 times amount for the first time, soak after 90 minutes, intense fire decocts boiling 10 minutes, again with slow fire boiling within 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container
2, by filtering medicinal residues add water 4 times amount, first boiling with high heat, then using slow fire boiling 30 minutes, second time decoction liquor is poured in container,
3, twice decoction liquor is carried out mixing and stirring, obtain medicinal liquid.
CN201410703844.2A 2014-11-30 2014-11-30 Medicine for treating hypertension and preparation method thereof Pending CN104352758A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104815192A (en) * 2015-04-30 2015-08-05 青岛市市立医院 Pharmaceutical composition for treating hypertension and application of pharmaceutical composition
CN105169034A (en) * 2015-09-10 2015-12-23 曾丽 Traditional Chinese medicine composition for treating hypertension and preparation method thereof
CN107551135A (en) * 2017-08-27 2018-01-09 方建秀 A kind of mulberry leaf disappear lipoid and reducing blood pressure tea and preparation method thereof

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CN104042936A (en) * 2014-07-07 2014-09-17 蚌埠火鹤制药有限公司 Traditional Chinese medicinal hypertension pill

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Publication number Priority date Publication date Assignee Title
CN104042936A (en) * 2014-07-07 2014-09-17 蚌埠火鹤制药有限公司 Traditional Chinese medicinal hypertension pill

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104815192A (en) * 2015-04-30 2015-08-05 青岛市市立医院 Pharmaceutical composition for treating hypertension and application of pharmaceutical composition
CN105169034A (en) * 2015-09-10 2015-12-23 曾丽 Traditional Chinese medicine composition for treating hypertension and preparation method thereof
CN107551135A (en) * 2017-08-27 2018-01-09 方建秀 A kind of mulberry leaf disappear lipoid and reducing blood pressure tea and preparation method thereof

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