CN105031102A - Medicine for treating hypertension and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating hypertension and a preparation method thereof. The medicine is mainly prepared by scutellaria baicalensis, cape jasmine, gentian, akebia stems, semen plantaginis, Chinese angelica, dried rehamnnia roots, rhizoma alismatis, Chinese thorowax roots, licorice, uncaria, selfheal, chrysanthemums, mulberry leaves and white paeony roots according to the weight proportion. The medicine for treating the hypertension has the functions of clearing heat-fire, promoting blood circulation to remove blood stasis and promoting blood circulation, is used for treating the hypertension and is fast in effect and good in treating effect, and the hypertension does not relapse.

Description

One treats hypertensive medicine and preparation method thereof

Technical field

The present invention relates to one and treat hypertensive medicine and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Hypertension refers to regulating blood pressure obstacle, makes systemic arterial blood pressure continue the pathological process raised.It is modal chronic disease, and be also the topmost risk factor of cardiovascular and cerebrovascular disease, long-term hypertension affects important organ, and especially the function of the heart, brain, kidney, finally causes Organ Failure.The traditional Chinese medical science is then thought due to liver, kidney, the heart, dys-splenism, cause negative and positive in body, QI and blood unbalance caused by.Because the side effect of western medicine hypertension is large, therefore there is great demand to effectively treating hypertensive Chinese medicine in people, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the effectively hypertensive medicine for the treatment of, thus completes the present invention.

Object of the present invention is just to provide the hypertensive Chinese medicine composition of a kind of effectively treatment.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Radix Scutellariae, Fructus Gardeniae, Radix Gentianae, Caulis Akebiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Rehmanniae, Rhizoma Alismatis, Radix Bupleuri, Radix Glycyrrhizae, Ramulus Uncariae Cum Uncis, Spica Prunellae, Flos Chrysanthemi, Folium Mori, the Radix Paeoniae Alba, Lumbricus, Cortex Moutan medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat hypertension.Wherein select Radix Scutellariae to be because its nature and flavor bitter cold, enter cardiopulmonary, gallbladder, large intestine channel, have removing the relative excess fire, except damp and hot, the function of arresting bleeding and miscarriage prevention, controls high fever excessive thirst, cough due to lung-heat.Select Fructus Gardeniae to be because its nature and flavor are bitter, cold, enter the heart, liver, lung, stomach warp, have heat clearing away, pathogenic fire purging, the function of removing heat from blood, control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Select Radix Gentianae to be that cold, enter liver, gallbladder meridian, have eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B because its nature and flavor are bitter, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Caulis Akebiae is selected to be that cool, enter the heart, small intestinal, urinary bladder channel, have pathogenic fire purging row water, the function of promoting blood circulation, controls hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis because its nature and flavor are bitter.Semen Plantaginis is selected to be that cold, enter kidney, urinary bladder channel, have diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, and arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view because its nature and flavor are sweet.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Radix Rehmanniae to be that cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid, and controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, and interior-heat is quenched one's thirst because its nature and flavor are sweet, spit blood, epistaxis, sends out speckle dermexanthesis.Select Rhizoma Alismatis to be that cold, enter urinary bladder channel, have diuretic, eliminating dampness by diuresis, the function expelled the heat-evil, controls dysuria because its nature and flavor are sweet, edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Radix Bupleuri to be that cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain because its nature and flavor are bitter, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Select Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, processs use, controls weakness of the spleen and stomach, lack of appetite, stomachache loose stool, and overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus ， Jing Epilepsy; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Ramulus Uncariae Cum Uncis to be because its nature and flavor are bitter, cool, enter liver, heart channel, have heat clearing away suppressing the hyperactive liver, the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., controls little Jing Epilepsy Chi Zong, adult's slight Hypertension, dizzy, dizzy, married woman's eclampsia.Select Spica Prunellae to be because its nature and flavor toil, cold, enter liver, gallbladder meridian, have liver heat removing, the function of eliminating stagnation, controls scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia is shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.Flos Chrysanthemi is selected to be that cool, enter lung, Liver Channel, have dispelling wind, disappear heat, improving eyesight, and the function of removing toxic substances, controls headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling because its nature and flavor sweetness and bitterness.Select Folium Mori to be because its property bitter but sweet flavor, cold, enter lung, Liver Channel, have expelling wind and clearing away heat, the function of cooling blood for improving eyesight, dispelling the wind and dampness pathogens generates heat, headache, and conjunctival congestion is thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Lumbricus is selected to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, have heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control high fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle ， Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:

Radix Scutellariae 120-180 gram, Fructus Gardeniae 120-180 gram, Radix Gentianae 50-80 gram, Caulis Akebiae 50-70 gram, Semen Plantaginis 120-180 gram, Radix Angelicae Sinensis 120-180 gram, Radix Rehmanniae 120-160 gram, Rhizoma Alismatis 120-160 gram, Radix Bupleuri 100-150 gram, Radix Glycyrrhizae 100-150 gram, Ramulus Uncariae Cum Uncis 120-160 gram, Spica Prunellae 120-180 gram, Flos Chrysanthemi 120-180 gram, Folium Mori 120-160 gram, Radix Paeoniae Alba 120-180 gram, Lumbricus 120-160 gram, Cortex Moutan 120-160 gram.

Be preferably:

Radix Scutellariae 150 grams, Fructus Gardeniae 150 grams, Radix Gentianae 60 grams, Caulis Akebiae 60 grams, Semen Plantaginis 150 grams, Radix Angelicae Sinensis 150 grams, Radix Rehmanniae 150 grams, Rhizoma Alismatis 150 grams, Radix Bupleuri 120 grams, 120 grams, Radix Glycyrrhizae, Ramulus Uncariae Cum Uncis 150 grams, Spica Prunellae 150 grams, Flos Chrysanthemi 150 grams, 150 grams, Folium Mori, the Radix Paeoniae Alba 150 grams, Lumbricus 150 grams, Cortex Moutan 150 grams.

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;

2, Fructus Gardeniae: sieve dedust bits, pick decontamination, pulverize and sieve or cut off two ends;

3, Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;

4, Caulis Akebiae: slightly soak with water, moistening, to thoroughly, is cut into slices, is dried;

5, Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;

6, Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;

7, Radix Rehmanniae: removing impurity, cleans, slightly moistens, cut sheet, and dry, sieve removes chip;

8, Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;

9, Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry;

10, Radix Glycyrrhizae: extracting liquorice sheet, adds the ripe Mel of white silk and boiled water is a little, mixes thoroughly, slightly vexed, and put in pot and fry to becoming buff with slow fire, till tack-free, taking-up cools, and 100 jin, every Radix Glycyrrhizae is with practicing ripe Mel 25-30 jin;

11, Ramulus Uncariae Cum Uncis: pick old stalk, impurity, cleans, dries;

12, Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;

13, Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;

14, Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;

15, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;

16, Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;

17, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries.

Two, prepare

1, the preparation of medicament capsule of the present invention:

(1) Radix Scutellariae cooked, Fructus Gardeniae, Radix Gentianae, Caulis Akebiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Rehmanniae, Rhizoma Alismatis, Radix Bupleuri, Radix Glycyrrhizae, Ramulus Uncariae Cum Uncis, Spica Prunellae, Flos Chrysanthemi, Folium Mori, the Radix Paeoniae Alba, Lumbricus, Cortex Moutan are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

(3) dry extract is broken into powder, incapsulates, every 0.5g.

2, the preparation of medicinal granule of the present invention:

(1) Radix Scutellariae cooked, Fructus Gardeniae, Radix Gentianae, Caulis Akebiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Rehmanniae, Rhizoma Alismatis, Radix Bupleuri, Radix Glycyrrhizae, Ramulus Uncariae Cum Uncis, Spica Prunellae, Flos Chrysanthemi, Folium Mori, the Radix Paeoniae Alba, Lumbricus, Cortex Moutan are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

(3) dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule.

3, the preparation of medicinal tablet of the present invention:

(1) Radix Scutellariae cooked, Fructus Gardeniae, Radix Gentianae, Caulis Akebiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Rehmanniae, Rhizoma Alismatis, Radix Bupleuri, Radix Glycyrrhizae, Ramulus Uncariae Cum Uncis, Spica Prunellae, Flos Chrysanthemi, Folium Mori, the Radix Paeoniae Alba, Lumbricus, Cortex Moutan are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

(3) dry extract is broken into fine powder, adds adjuvant and make granule, tabletted, every section of 0.5g.

4, the preparation of medicine honeyed pill of the present invention:

(1) by cook Radix Scutellariae, Fructus Gardeniae, Radix Gentianae, Caulis Akebiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Rehmanniae, Rhizoma Alismatis, Radix Bupleuri, Radix Glycyrrhizae, Ramulus Uncariae Cum Uncis, Spica Prunellae, Flos Chrysanthemi, Folium Mori, the Radix Paeoniae Alba, Lumbricus, Cortex Moutan mixing and stirring, porphyrize powder crosses 200 order dusting covers;

(2) Mel is refined into the tender honey of 110-115 DEG C;

(3) by grind for fine powder spice by weight the ratio of 1:1 add mixing system in Mel and stick together, then rubbing pill, 1.5 grams, every ball.

Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver in prescription, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. is for monarch drug; Cortex Moutan heat clearing away, removing heat from blood, and blood, repercussive; Fructus Gardeniae has heat clearing away, pathogenic fire purging, the function of removing heat from blood, and the two is ministerial drug, three taste medicines play heat clearing away, removing heat from blood jointly, and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion, the effect of repercussive, treatment hypertension effect is comprehensive, and with clearing away heat-fire, be that master can be effected a permanent cure with blood blood stasis dispelling, Radix Rehmanniae has clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid is adjuvant drug, Radix Glycyrrhizae and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription is for making medicine, and all medicines take stopgap measures with being left.

Medicine of the present invention has clearing away heat-fire, and blood blood stasis dispelling, and the function of promoting blood circulation, is used for the treatment of hypertension, short treating period, instant effect, non-relapse after healing.

Detailed description of the invention:

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention:

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group oral capsule, a kind of dosage form in granule or tablet is 0.2g/kg, and normal amount is 0.1g/kg, administering mode is the administration of dilution administration by gavage, twice daily, serve on 7 days, observe administration reaction every day, result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept Hypertension Clinic patient totally 60 examples for medical treatment.

2, diagnostic criteria

Hypertensive early symptom is not obvious, blood pressure only can occur after fatigue, psychentonia, anxious state of mind and raise, and recover normal after rest.Along with the course of disease extends, blood pressure significantly continues to raise, and there will be various symptom, as headache, dizzy, absent minded, hypomnesis, numb limbs and tense tendons, nocturia increase, cardiopalmus, uncomfortable in chest, weak etc.When blood pressure is elevated to a certain degree suddenly, even there will be severe headache, vomiting, cardiopalmus, the symptom such as dizzy, obnubilation, tic can be there is time serious, how infringement and the pathological changes of the organs such as the serious heart, brain, kidney can occur in a short time, as apoplexy, heart infarction, renal failure etc.

The standard of current domestic hypertensive diagnosis employing Chinese Treatment Guidelines for Hypertension suggestion in 2000:

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with capsule or granule or 4 grams, tablet, or honeyed pill 6 ball, every day is early, middle and late respectively takes 1 time, within 10 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: hypertension symptom disappears, blood pressure recovers normal value, and recovery from illness, follows up a case by regular visits to and do not recur half a year;

Take a turn for the better: patient, headache, dizzy phenomenon alleviate, and three grades of hypertension reduce to secondary by three grades, and secondary hypertension reduces to one-level by secondary;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, with Drug therapy one-level hyperpietic 26 people of the present invention, effective 23 people of result, take a turn for the better 3 people, and obvious effective rate is 88.46%, and total effective rate is 100%; Treatment secondary hyperpietic 18 people, effective 12 people of result, take a turn for the better 5 people, invalid 1 people, and obvious effective rate is 66.67%, and total effective rate is 94.45%; Treat three grades of hyperpietic 16 people, effective 12 people, take a turn for the better 3 people, invalid 1 people, and obvious effective rate is 75%, total effective rate 93.75%.

Claims (3)

1. treat a hypertensive medicine, it is characterized in that: it is made up of the crude drug in following weight range:

Radix Scutellariae 120-180 gram, Fructus Gardeniae 100-200 gram, Radix Gentianae 50-80 gram, Caulis Akebiae 50-100 gram, Semen Plantaginis 120-180 gram, Radix Angelicae Sinensis 100-180 gram, Radix Rehmanniae 120-150 gram, Rhizoma Alismatis 100-200 gram, Radix Bupleuri 100-150 gram, Radix Glycyrrhizae 100-160 gram, Ramulus Uncariae Cum Uncis 120-160 gram, Spica Prunellae 120-180 gram, Flos Chrysanthemi 100-200 gram, Folium Mori 100-160 gram, Radix Paeoniae Alba 120-180 gram, Lumbricus 120-150 gram, Cortex Moutan 100-150 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Radix Scutellariae 150 grams, Fructus Gardeniae 150 grams, Radix Gentianae 60 grams, Caulis Akebiae 60 grams, Semen Plantaginis 150 grams, Radix Angelicae Sinensis 150 grams, Radix Rehmanniae 150 grams, Rhizoma Alismatis 150 grams, Radix Bupleuri 120 grams, 120 grams, Radix Glycyrrhizae, Ramulus Uncariae Cum Uncis 150 grams, Spica Prunellae 150 grams, Flos Chrysanthemi 150 grams, 150 grams, Folium Mori, the Radix Paeoniae Alba 150 grams, Lumbricus 150 grams, Cortex Moutan 150 grams.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;

(2) Fructus Gardeniae: sieve dedust bits, pick decontamination, pulverize and sieve or cut off two ends;

(3) Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;

(4) Caulis Akebiae: slightly soak with water, moistening, to thoroughly, is cut into slices, is dried;

(5) Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;

(6) Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;

(7) Radix Rehmanniae: removing impurity, cleans, slightly moistens, cut sheet, and dry, sieve removes chip;

(8) Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;

(9) Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry;

(10) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;

(11) Ramulus Uncariae Cum Uncis: pick old stalk, impurity, cleans, dries;

(12) Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;

(13) Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;

(14) Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;

(15) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;

(16) Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;

(17) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

(2) prepare

(1) preparation of medicament capsule of the present invention:

1. the Radix Scutellariae cooked, Fructus Gardeniae, Radix Gentianae, Caulis Akebiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Rehmanniae, Rhizoma Alismatis, Radix Bupleuri, Radix Glycyrrhizae, Ramulus Uncariae Cum Uncis, Spica Prunellae, Flos Chrysanthemi, Folium Mori, the Radix Paeoniae Alba, Lumbricus, Cortex Moutan are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

3. dry extract is broken into powder, incapsulates;

(2) preparation of medicinal granule of the present invention:

1. the Radix Scutellariae cooked, Fructus Gardeniae, Radix Gentianae, Caulis Akebiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Rehmanniae, Rhizoma Alismatis, Radix Bupleuri, Radix Glycyrrhizae, Ramulus Uncariae Cum Uncis, Spica Prunellae, Flos Chrysanthemi, Folium Mori, the Radix Paeoniae Alba, Lumbricus, Cortex Moutan are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

3. dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule;

(3) preparation of medicinal tablet of the present invention:

1. the Radix Scutellariae cooked, Fructus Gardeniae, Radix Gentianae, Caulis Akebiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Rehmanniae, Rhizoma Alismatis, Radix Bupleuri, Radix Glycyrrhizae, Ramulus Uncariae Cum Uncis, Spica Prunellae, Flos Chrysanthemi, Folium Mori, the Radix Paeoniae Alba, Lumbricus, Cortex Moutan are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

3. dry extract is broken into fine powder, adds adjuvant and make granule, tabletted.