A kind of medicine for the treatment of hemiplegia and preparation method thereof
The present invention relates to a kind of medicine for the treatment of hemiplegia and preparation method thereof, belong to the field of Chinese medicines.
Hemiplegia is hemiplegia again, and refer to the dyskinesia of side upper and lower extremities, facial muscle and lingualis bottom, it is a common sympton of acute cerebrovascular disease.Although slight hemiplegic patient still can be movable, walk, often upper limb flexing, lower limb stretch, and the lower limb of paralysis make a move and draw half circle, and we, this special walking posture, are called hemiplegic gait.Severe patient is often unable to leave the bed, and loses viability.Modern medicine is thought, hemiplegia is many because of caused by cerebrovascular disease, the symptom such as even to go into a coma as rupture of blood vessel in brain, thromboembolism, spasm etc. cause central nervous system pathological change and dizziness, headache, vomiting, numb limbs and tense tendons, tic, paralysis, unconsciousness occur, some patients are dead immediately.Because current Western medicine effectively cannot treat hemiplegia, therefore there is great demand in the Chinese medicine of people to rapid, effective treatment hemiplegia, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment hemiplegia, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment hemiplegia.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Radix Glycyrrhizae, Concretio Silicea Bambusae, Radix Rehmanniae, Arisaema Cum Bile, Bombyx Batryticatus, the Rhizoma Pinelliae, Radix Gentianae, Fructus Crataegi, Cortex Moutan, Rhizoma Polygonati Odorati, Fructus Tribuli, Herba Lycopodii, Caulis Spatholobi, Radix Paeoniae Rubra, Flos Chrysanthemi, Concha Haliotidis, Rhizoma Gastrodiae, Flos Carthami, Scolopendra, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Semen Persicae, Lumbricus, Agkistrodon, Cornu Saigae Tataricae, the Cortex Eucommiae, Hirudo, Scorpio, Herb Gynostemmae Pentaphylli medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat hemiplegia.Wherein select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Concretio Silicea Bambusae to be that GUIXIN, Liver Channel, have clear heat and eliminate phlegm because its nature and flavor are sweet, the function of cool heart arresting convulsion, controls calentura coma, middle wind-phlegm fan, the hot infantile convulsion of children's's expectorant, twitches, night cry.Select Radix Rehmanniae to be that cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid, and controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, and interior-heat is quenched one's thirst because its nature and flavor are sweet, spit blood, epistaxis, sends out speckle dermexanthesis.Arisaema Cum Bile is selected to be that cool in nature, enter the heart, liver, lung three warp, have clearing away fire and eliminating phlegm, relieving convulsion Epilepsy of Dinging, phlegm-fire is breathed heavily and coughed, phlegm-accumulating vertigo because its nature and flavor are bitter.Bombyx Batryticatus is selected to be because its nature and flavor are pungent salty, flat, enter liver, lung, stomach warp, have expelling wind to relieve convulsion, the function of dissipating phlegm and resolving masses, control apoplectic aphasia ， Jing Epilepsy, wind syndrome of head, acute throat trouble, sore throat, scrofula tuberculosis, wind skin ulcer urticaria, erysipelas, mastitis.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, outer subduing inflammation.Select Radix Gentianae to be that cold, enter liver, gallbladder meridian, have eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B because its nature and flavor are bitter, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Select Fructus Crataegi be because its nature and flavor acid sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle ， Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Select Rhizoma Polygonati Odorati to be that flat, enter lung, stomach warp, has yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst because its nature and flavor are sweet, control calentura sun wound, cough, excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.Select Fructus Tribuli to be because its nature and flavor toil, temperature, enter liver, lung meridian, have loose wind, improving eyesight, the therapeutic method to keep the adverse QI flowing downwards, the function of promoting the circulation of blood, controls headache, itching over the body, and conjunctival congestion swells nebula, and fullness in the chest, cough with dyspnea ， mass in the abdomen, breast is difficult, carbuncle, scrofula.Select Herba Lycopodii to be because its nature and flavor toil, temperature, enters liver, stomach, kidney three warp, has expelling wind and cold, and dehumidifying detumescence, the function of relaxing muscles and tendons to promote blood circulation, controls anemofrigid-damp arthralgia, joint aches, skin numbness, tetraparesis, edema, traumatic injury.Select Caulis Spatholobi to be because its property bitter but sweet flavor, temperature, enters the heart, spleen two warp, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, control warm poison and go mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Flos Chrysanthemi is selected to be that cool, enter lung, Liver Channel, have dispelling wind, disappear heat, improving eyesight, and the function of removing toxic substances, controls headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling because its nature and flavor sweetness and bitterness.Select Concha Haliotidis to be because its nature and flavor are salty, flat, enter liver, kidney channel, have suppressing the hyperactive liver and subsiding YANG, heat extraction, the function of improving eyesight, controls wind-yang and up-boring, has a headache dizzy, shies and jerks, hectic fever due to YIN-deficiency consumptive fever, optic atrophy.Select Rhizoma Gastrodiae to be because its nature and flavor are sweet, flat, enter Liver Channel, have endogenous wind stopping, the function of arresting convulsion, control dizzy pupil, wind syndrome of head is had a headache, numb limbs and tense tendons, hemiplegia, aphasia, little Jing Epilepsy wind symptom.Select Flos Carthami to be that temperature, enters the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea ， mass in the abdomen because its nature and flavor are pungent, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Scolopendra to be because its nature and flavor are pungent, temperature, poisonous, enter Liver Channel, dispel the wind, arresting convulsion, counteracting toxic substances, the function of eliminating stagnation, controls apoplexy ， Jing Epilepsy, tetanus, pertussis, Ji scrofula, tuberculosis ， mass in the abdomen tumor block, sore swollen toxin, and tinea corporis is bald in vain, anal fistula, scalds.Select Ramulus Uncariae Cum Uncis to be because its nature and flavor are bitter, cool, enter liver, heart channel, have heat clearing away suppressing the hyperactive liver, the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., controls little Jing Epilepsy Chi Zong, adult's slight Hypertension, dizzy, dizzy, married woman's eclampsia.Radix Salviae Miltiorrhizae is selected to be that tepor, enters the heart, Liver Channel, have blood circulation and promoting silt, calming heart and tranquilizing mind, evacuation of pus, and the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, and to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia because its nature and flavor are bitter, palpitation with fear sleeplessness, malignant boil toxic swelling.Semen Persicae is selected to be because its property bitter but sweet flavor, flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Lumbricus is selected to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, have heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control high fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Agkistrodon to be because its property sweet-salty, temperature, poisonous, enter liver, spleen channel, have wind-damp dispelling, saturating muscles and bones, the function of jerking of calming the frightened, dispelling the wind and dampness pathogens is paralysed, and arthralgia, leprosy, mange, infantile convulsion is twitched, tetanus, syphilitic skin lesion, scrofula malignant boil.Select Cornu Saigae Tataricae to be because its nature and flavor are salty, cold, enter liver, heart channel, have suppressing the hyperactive liver to relieve the wind syndrome, heat clearing away is relieving convulsion, the function of removing toxic substances, and control calentura coma convulsion and faint, delirium is gone mad, and dizzy ， Jing Epilepsy of having a headache is twitched, conjunctivitis.Select the Cortex Eucommiae be because its nature and flavor sweet micro-pungent, temperature, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, antiabortive function, control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, hypertension.Select Hirudo to be because the salty hardship of its nature and flavor, flat, poisonous, enter liver, urinary bladder channel, have removing blood stasis, removing blood stasis, the function of stimulating the menstrual flow, control blood-retention ， mass in the abdomen, gather, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, conjunctival congestion with ophthalmalgia, nebula.Select Scorpio to be because its nature and flavor are salty pungent, flat, poisonous, enter meridian of Foot-JUE YIN, dispel the wind, relieving convulsion, dredging collateral, the function of removing toxic substances, control convulsion with spasms ， epilepsy, apoplexy, hemiplegia, deviation of the eye and mouth, migraine, rheumatic arthralgia, tetanus, tuberculous lymphadenitis, rubella skin ulcer swells.Herb Gynostemmae Pentaphylli is selected to be that cold, return lung, spleen, kidney channel, have heat-clearing and toxic substances removing, eliminating phlegm and stopping cough, the function of promoting the production of body fluid and inducing sedation of the mind, controls chronic bronchitis, infectious hepatitis, pyelonephritis, gastroenteritis, cardiovascular diseases because its nature and flavor are bitter.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following dosage
Radix Glycyrrhizae 5-10 gram of Concretio Silicea Bambusae 8-18 gram of Radix Rehmanniae 10-20 gram
Arisaema Cum Bile 8-18 gram of Bombyx Batryticatus 12-22 gram of Rhizoma Pinelliae 10-20 gram
Radix Gentianae 5-10 Keshan short, bristly hair or beard 25-35 gram of Cortex Moutan 12-22 gram
Rhizoma Polygonati Odorati 10-18 gram of Fructus Tribuli 18-25 gram of Herba Lycopodii 12-22 gram
Caulis Spatholobi 10-20 gram of Radix Paeoniae Rubra 20-30 gram of Flos Chrysanthemi 25-35 gram
Concha Haliotidis 25-35 gram of Rhizoma Gastrodiae 15-25 gram of Flos Carthami 4-12 gram
Scolopendra 2-4 bar Ramulus Uncariae Cum Uncis 25-35 gram of Radix Salviae Miltiorrhizae 12-20 gram
Semen Persicae 12-22 gram of Lumbricus 10-20 gram of Agkistrodon 1-2 bar
Cornu Saigae Tataricae 2-4 gram Cortex Eucommiae 10-18 gram Hirudo 5-10 gram
Scorpio 2-4 bar Herb Gynostemmae Pentaphylli 12-22 gram
Radix Glycyrrhizae 6 grams of Concretio Silicea Bambusaes 10 grams of Radix Rehmanniae 15 grams
Arisaema Cum Bile 10 grams of Bombyx Batryticatus 15 grams of Rhizoma Pinelliaes 12 grams
Radix Gentianae 6 Keshan short, bristly hair or beard 30 grams of Cortex Moutans 15 grams
Rhizoma Polygonati Odorati 15 grams of Fructus Tribulis 20 grams of Herba Lycopodiis 15 grams
Caulis Spatholobi 15 grams of Radix Paeoniae Rubra 24 grams of Flos Chrysanthemis 30 grams
5 grams, Concha Haliotidis 30 grams of Rhizoma Gastrodiaes 20 grams of Flos Carthamis
Scolopendra 3 Ramulus Uncariae Cum Uncis 30 grams of Radix Salviae Miltiorrhizaes 15 grams
Semen Persicae 15 grams of Lumbricuss 15 grams of Agkistrodons 1
Cornu Saigae Tataricae 3 grams of Cortexs Eucommiae 15 grams of Hirudos 6 grams
Scorpio 3 Herb Gynostemmae Pentaphylli 15 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
2, Concretio Silicea Bambusae: get crude drug, removing impurity, ash bits;
3, Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;
4, Arisaema Cum Bile: get crude drug, picks decontamination;
5, Bombyx Batryticatus: pick silk hair, cleans dirt, dries;
6, the Rhizoma Pinelliae: pick decontamination, sieve dedust bits;
7, Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;
8, Fructus Crataegi: pick clean impurity, sieve enucleation;
9, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;
10, Rhizoma Polygonati Odorati: removing impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;
11, Fructus Tribuli: silt is removed in drift, the hard thorn that Ex-all is residual;
12, Herba Lycopodii: sieve dedust bits, pick clean impurity, be cut into segment;
13, Caulis Spatholobi: run through with water, section, or steam soft after cut into slices while hot, dry;
14, Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;
15, Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;
16, Concha Haliotidis: clean and dry, knock fragment;
17, Rhizoma Gastrodiae: pick decontamination, size stepping, be soaked in water to seventy percent thoroughly, pull out, slightly dry in the air, then moisten to internal and external temperature even, section, dries;
18, Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
19, Scolopendra: wipe clean, removing cephalopodium, cuts off use;
20, Ramulus Uncariae Cum Uncis: pick old stalk, impurity, cleans, dries;
21, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
22, Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;
23, Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;
24, Agkistrodon: strike off end to end, warm water softens, dice dries;
25, Cornu Saigae Tataricae: except plug of boning, enter in water after dipping, pull muscle out, pound becomes longitudinal thin slice, dries;
26, the Cortex Eucommiae: removing rough bark, clean, run through, dice or strand, dry;
27, Hirudo: clean, vexed soft, cutting, dries;
28, Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;
29, Herb Gynostemmae Pentaphylli: get crude drug, removing impurity, cleans, slightly dries in the air, cutting, dry.
1, the Radix Glycyrrhizae of described weight, Concretio Silicea Bambusae, Radix Rehmanniae, Arisaema Cum Bile, Bombyx Batryticatus, the Rhizoma Pinelliae, Radix Gentianae, Fructus Crataegi, Cortex Moutan, Rhizoma Polygonati Odorati, Fructus Tribuli, Herba Lycopodii, Caulis Spatholobi, Radix Paeoniae Rubra, Flos Chrysanthemi, Concha Haliotidis, Rhizoma Gastrodiae, Flos Carthami, Scolopendra, Ramulus Uncariae Cum Uncis, Radix Salviae Miltiorrhizae, Semen Persicae, Lumbricus, Agkistrodon, Cornu Saigae Tataricae, the Cortex Eucommiae, Hirudo, Scorpio, Herb Gynostemmae Pentaphylli are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor.
2, add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor.
3, merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into 4 doses to take.
Medicine of the present invention has the function that expelling wind to relieve convulsion and blood repercussive, relaxing muscles and tendons stimulate the menstrual flow, and is used for the treatment of hemiplegia instant effect, good effect.Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 100 examples for medical treatment.
2, diagnostic criteria
According to the degree of hemiplegia, paresis, paresis and panplegia can be divided into.Paresis: show as muscular strength and weaken, muscular strength, in 4-5 level, does not generally affect daily life, and imperfection paralysis is paresis weight comparatively, and scope is comparatively large, muscular strength 2-4 level, panplegia: muscular strength 0-1 level, paralyzed limbs is completely stiff.According to the degree of hemiplegia, paresis, paresis and panplegia can be divided into.Paresis: show as muscular strength and weaken, muscular strength, at 4 ~ 5 grades, does not generally affect daily life, and imperfection paralysis is paresis weight comparatively, and scope is comparatively large, muscular strength 2 ~ 4 grades, panplegia: muscular strength 0 ~ 1 grade, paralyzed limbs is completely stiff.
3, Therapeutic Method
Selecting above-mentioned medicament, take to patient, every day 2 times, each 1 dose, 30 days is a course for the treatment of, takes 3-4 the course for the treatment of continuously.
4, efficacy assessment standard
Effective: the hemiplegia state of an illness is controlled, the function of hemiplegia is recovered, and observes half a year without recidivist.
Take a turn for the better: hemiplegia disease states alleviates, and patient sign improves, and the state of an illness progressively takes a turn for the better.
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by Drug therapy hemiplegia patient 100 example of the present invention, effective 70 examples of result, obvious effective rate is 70%, and take a turn for the better 12 examples, and improvement rate is 12%, and invalid 18 examples, total effective rate is 82%.