CN105435186A - Medicine for treating pediatric pertussis and preparation method of medicine - Google Patents

Abstract

The invention discloses a medicine for treating pediatric pertussis and a preparation method of the medicine. The medicine is mainly prepared from cacumen biotae, semen lepidii, duckweed, pericarpium citri reticulatae viride, pericarpium citri reticulatae, semen arecae, rheum officinale, ginger, ephedra, apricot kernels, gypsum and liquorice at a certain weight ratio. The medicine has the functions of expelling phlegm to arrest coughing, relieving asthma and clearing heat, and is fast to take effect, good in curative and free of relapse when being applied to treatment of the pediatric pertussis.

Description

A kind of medicine for the treatment of infantile pertussis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of infantile pertussis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Infantile pertussis is a kind of by the microbial Acute respiratory infectious disease of infantile pertussis bar, Clinical symptoms increases the weight of gradually for cough, and in typical paroxysmal, spasmodic cough, cough eventually end occurs that profound chicken crows sample inspiratory croup, the course of disease reaches 2 ~ 3 months, therefore has the title of infantile pertussis.At present, because Western medicine effectively cannot treat infantile pertussis, therefore there is great demand to the Chinese medicine of effectively treating infantile pertussis in people, up to now, also do not find the relevant report about medicine of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally successfully have found the medicine of effectively treatment infantile pertussis, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment infantile pertussis.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Cacumen Platycladi selected by medicine of the present invention, Semen Lepidii (Semen Descurainiae), Herba Spirodelae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Semen Arecae, Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Herba Asari, Fructus Perillae, Semen Sinapis Albae, Fructus Arctii, Pericarpium Trichosanthis, Rhizoma Belamcandae, Indigo Naturalis, Concha Meretricis seu Cyclinae, Radix Trichosanthis, Fructus Gardeniae, Rhizoma Cynanchi Stauntonii, Radix Peucedani, Radix Asteris, Cortex Magnoliae Officinalis, Fructus Mume, Folium Eriobotryae, the Radix Stemonae, Cortex Mori, Radix Asparagi, the Rhizoma Anemarrhenae, Radix Platycodonis, Caulis Bambusae In Taenia, Herba Gnaphalii Affinis, Poria, Radix Polygoni Multiflori, Pumex medicine carries out combination preparation, each efficacy of drugs is made by these drug regimens to produce synergism, thus effectively can treat the recurrence of infantile pertussis.Wherein, Cacumen Platycladi is selected to be because its nature and flavor are pained, cold, enter the heart, liver, large intestine channel, have removing heat from blood, hemostasis, wind-damp dispelling, the function of loose toxic swelling, controls haematemesis, epistaxis, hematuria, dysentery, hemorrhoidal hamorrhage, metrorrhagia, rheumatic arthralgia, bacillary dysentery, hypertension, cough, erysipelas, mumps, scalds.Select Semen Lepidii (Semen Descurainiae) to be because its nature and flavor are pungent, bitter, in Great Cold, return lung, urinary bladder channel, have eliminating pathogen from the lung for relieving asthma, the function of inducing diuresis to remove edema, control sputum and stop up lung, cough with asthma abundant expectoration, fullness and distention in the chest and hypochondrium, ascites pleural fluid swells, dysuria and pulmonary heart disease edema.Select Herba Spirodelae to be because its nature and flavor are pungent, cold, enter lung meridian, have diaphoresis, dispel the wind, row water, heat clearing away, the function of removing toxic substances, row calentura when controlling, macule is not saturating, wind heat urticaria, skin pruritus, edema, the difficulty in urination, skin ulcer tinea, and erysipelas is scalded.Select Pericarpium Citri Reticulatae Viride to be that tepor, enters liver, gallbladder meridian, has soothing the liver dispelling the stagnated QI, the function of eliminating stagnation expectorant because its nature and flavor toil, control breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction block.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Select Semen Arecae to be because its nature and flavor toil, temperature, enters spleen, stomach, large intestine channel, has parasite killing, removing mass, the therapeutic method to keep the adverse QI flowing downwards, the function of row water, control malnutrition due to parasitic infestation, dyspepsia, abdominal distention, and heavy after dysentery, malaria, edema, beriberi, accumulation of phlegm in the hypochondrium ， Disorder ties.Radix Et Rhizoma Rhei is selected to be that enter stomach, large intestine, liver footpath, have the poison that purges heat, removing mass is stagnant because its nature and flavor are bitter, cold, the function of clots absorbing blood, control excess-heat constipation, delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Select Rhizoma Zingiberis Recens to be because its nature and flavor are pungent, temperature, enter lung, stomach, spleen channel, deliver, cold expelling, preventing or arresting vomiting, open the function of expectorant, cure cold wind and cold, vomiting, and phlegm retention, breathes with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Herba Ephedrae is selected to be that temperature, enters lung, urinary bladder channel, have diaphoresis, relieving asthma because its nature and flavor are worked hard, the function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache nasal obstruction, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Semen Armeniacae Amarum is selected to be that temperature, poisonous, enter lung, large intestine channel, have expelling phlegm for arresting cough, relieving asthma, the function of intestine moistening, controls exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation because its nature and flavor are bitter.Gypsum Fibrosum is selected to be because its property acrid-sweet flavor, cold, enter lung, stomach warp, raw with there being expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst, controls calentura high fever and does not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue, forges deposited promoting tissue regeneration and ulcer healing, external treatment ulcer sores, bursts and does not regain, the burning hot wound of soup.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Herba Asari to be that temperature, enters lung, kidney channel, dispel the wind, cold expelling, row water because its nature and flavor are pungent, open the function of stealing, control air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Fructus Perillae is selected to be that temperature, enter lung, large intestine channel, have the therapeutic method to keep the adverse QI flowing downwards, expectorant, lung moistening, the function of wide intestinal, controls cough with dyspnea, phlegm dyspnea, the stagnation of QI, constipation because its nature and flavor are pungent.Select Semen Sinapis Albae to be that temperature, enters lung, stomach warp, have promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, the function of removing obstruction in the collateral to relieve pain, control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain because its nature and flavor are pungent, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Select Fructus Arctii to be that cool, enter lung, stomach warp, have dispelling wind and heat pathogens, lung qi dispersing rash, the function of subduing swelling and detoxicating, controls cough due to pathogenic wind-heat, laryngopharynx swelling and pain because its nature and flavor are worked hard, macule is not saturating, and rubella is had an itch, carbuncle sore tumefacting virus.Pericarpium Trichosanthis is selected to be that cold, attach to the lung and stomach meridians, have removing heat-phlegm, the function of promoting the circulation of QI the chest stuffiness relieving, controls phlegm-heat cough, hypochondriac pain uncomfortable in chest because its nature and flavor are sweet.Select Rhizoma Belamcandae to be because its nature and flavor are bitter, cold, poisonous, enter lung, Liver Channel, have pathogenic fire reducing, removing toxic substances, loose blood, the function of expectorant, controls sore throat pharyngalgia, cough with dyspnea, accumulation and obstruction of sputum, scrofula tuberculosis, malaria with splenomegaly, women's amenorrhea, carbuncle sore tumefacting virus.Select Indigo Naturalis to be because its nature and flavor are salty, cold, enter liver, lung, stomach warp, have heat clearing away, removing heat from blood, the function of removing toxic substances, control epidemic febrile disease intenseness of heat, macule, spit blood, spit blood, little Jing Epilepsy, skin ulcer swells, erysipelas, snake bite and insect sting.Select Concha Meretricis seu Cyclinae to be because its nature and flavor are salty, flat, enter brothers' sun, Yangming Channel, have heat clearing away, diuretic, reduce phlegm, the function of softening the hard mass, control heat-phlegm and breathe heavily and cough, edema, gonorrhea, wart, tumor, gather, blood agglomeration chest pain, dysentery, hemorrhoid, metrorrhagia, leukorrhagia.Radix Trichosanthis is selected to be that cool, enter lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturize, evacuation of pus, the function of detumescence, controls calentura thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula because its nature and flavor sweetness and bitterness acid.Select Fructus Gardeniae to be because its nature and flavor are bitter, cold, enter the heart, liver, lung, stomach warp, have heat clearing away, pathogenic fire purging, the function of removing heat from blood, control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Rhizoma Cynanchi Stauntonii is selected to be that tepor, returns lung meridian, has eliminating the pathogens from the lung sending down the abnormal ascending QI, and the function of lower phlegm and relieving cough, controls excess of the lung dyspnea with fullness of the chest because its property acrid-sweet flavor, cough, excessive phlegm, gastralgia.Select Radix Peucedani to be that be slightly cold, return lung meridian, have loose wind heat clearing away, the function of lowering the adverse-rising QI to resolve phlegm, controls cough due to pathogenic wind-heat, abundant expectoration because its nature and flavor are pungent, bitter, expectorant dyspnea of heat type is full, coughs up phlegm yellow thick.Select Radix Asteris to be because its nature and flavor are bitter, temperature, enter lung meridian, have warming the lung, the therapeutic method to keep the adverse QI flowing downwards, water expectorant, the function of cough-relieving, controls wind and cold, and cough, Zhichuan, asthenia coughs vomiting bloody pus.Select Cortex Magnoliae Officinalis to be because its nature and flavor toil, temperature, enter spleen, stomach, large intestine channel, have warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, the function of expectorant, control breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, cold-damp dysentery.Fructus Mume is selected to be that temperature, enter liver, spleen, lung, large intestine channel, have convergence to promote the production of body fluid, the function of relieving colic caused by ascaris anthelmintic, controls chronic cough, deficiency-heat excessive thirst, chronic malaria, and dysentery, has blood in stool, hematuria, metrorrhagia, and the ascariasis of biliary tract is suffered from abdominal pain, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp because its nature and flavor acid.Select Folium Eriobotryae to be because its nature and flavor are bitter, cool, attach to the lung and stomach meridians, have lung heat clearing stomach function regulating, lowering the adverse-rising QI to resolve phlegm, control lung-heat phlegmatic cough, hemoptysis, epistaxis, gastric heat is vomitted the sound of vomiting.The Radix Stemonae is selected to be that tepor, enters lung meridian, has gentle lung qi, cough-relieving, and the function of parasite killing, controls cough due to wind and cold, infantile pertussis, pulmonary tuberculosis, old cough with asthma, ascarid, enterobiasis, skin scabies, eczema because its nature and flavor sweetness and bitterness.Select Cortex Mori to be that cold, enter lung, spleen channel, have eliminating pathogen from the lung for relieving asthma, the function of line water detumescence, controls dyspnea and cough due to lung-heat because its nature and flavor are sweet, spit blood, edema, beriberi, dysuria.Select Radix Asparagi to be because its nature and flavor sweetness and bitterness, cold, enter lung, kidney channel, have YIN nourishing, moisturize, lung heat clearing, the function of pathogenic fire reducing, controls fever due to yin deficiency, and cough is spitted blood, and consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.The Rhizoma Anemarrhenae is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Radix Platycodonis to be because its nature and flavor toil, flat, enter lung, stomach warp, have out lung qi dispersing gas, the function of evacuation of pus of eliminating the phlegm, controls exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, and dysentery is suffered from abdominal pain.Select Caulis Bambusae In Taenia to be because its nature and flavor are sweet, cool, enter stomach, gallbladder meridian, have heat clearing away, removing heat from blood, reduce phlegm, the function of emesis, control dysphoria with smothery sensation vomiting, singultus, expectorant heat syndrome cough is breathed heavily, and spits blood, epistaxis, metrorrhagia, malignant histocytosis, fetal movement ， Jing Epilepsy.Herba Gnaphalii Affinis is selected to be that flat, enter lung meridian, have and reduce phlegm, cough-relieving, the function of cold-dispelling, controls cough with copious phlegm because its nature and flavor are sweet, asthma, cold, favism, bones and muscles pain, leucorrhea, carbuncle and ulcer.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Radix Polygoni Multiflori is selected to be that tepor, enters liver, kidney channel, have tonifying liver, kidney tonifying, nourish blood, the function of dispeling the wind because its property bitter but sweet flavor is puckery, control hepatic and renal YIN deficiency, sending out must be early white, and blood deficiency is dizzy, and waist knee joint is weak, and muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Select Pumex to be because its nature and flavor are salty-cold, enter lung, stomach warp, have lung heat clearing fire, change old expectorant, softening the hard mass, treating stranguria function, control expectorant dyspnea of heat type and cough, old accumulation of phlegm block, goiter, scrofula, hernia, skin ulcer swells, corneal nebula.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:

Cacumen Platycladi 40-50 gram, Semen Lepidii (Semen Descurainiae) 30-40 gram, Herba Spirodelae 40-60 gram, Pericarpium Citri Reticulatae Viride 35-45 gram, Pericarpium Citri Reticulatae 30-50 gram, Semen Arecae 5-8 gram, Radix Et Rhizoma Rhei 10-20 gram, Rhizoma Zingiberis Recens 8-12 gram, Herba Ephedrae 4-6 gram, Semen Armeniacae Amarum 40-60 gram, Gypsum Fibrosum 20-30 gram, Radix Glycyrrhizae 8-12 gram, Herba Asari 4-6 gram, Fructus Perillae 30-40 gram, Semen Sinapis Albae 8-12 gram, Fructus Arctii 10-15 gram, Pericarpium Trichosanthis 20-30 gram, Rhizoma Belamcandae 15-20 gram, Indigo Naturalis 8-10 gram, Concha Meretricis seu Cyclinae 15-20 gram, Radix Trichosanthis 10-15 gram, Fructus Gardeniae 10-20 gram, Rhizoma Cynanchi Stauntonii 10-20 gram, Radix Peucedani 12-16 gram, Radix Asteris 14-18 gram, Cortex Magnoliae Officinalis 5-8 gram, Fructus Mume 10-20 gram, Folium Eriobotryae 20-30 gram, Radix Stemonae 10-15 gram, Cortex Mori 10-15 gram, Radix Asparagi 8-12 gram, Rhizoma Anemarrhenae 6-12 gram, Radix Platycodonis 10-20 gram, Caulis Bambusae In Taenia 6-10 gram, Herba Gnaphalii Affinis 10-20 gram, Poria 6-10 gram, Radix Polygoni Multiflori 15-25 gram, Pumex 6-10 gram.

Be preferably:

Cacumen Platycladi 45 grams, Semen Lepidii (Semen Descurainiae) 35 grams, 50 grams, Herba Spirodelae, 40 grams, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae 40 grams, Semen Arecae 6 grams, Radix Et Rhizoma Rhei 15 grams, 10 grams, Rhizoma Zingiberis Recens, 4 grams, Herba Ephedrae, 50 grams, Semen Armeniacae Amarum, 25 grams, Gypsum Fibrosum, 10 grams, Radix Glycyrrhizae, Herba Asari 4 grams, Fructus Perillae 30 grams, Semen Sinapis Albae 10 grams, Fructus Arctii 12 grams, Pericarpium Trichosanthis 25 grams, Rhizoma Belamcandae 16 grams, Indigo Naturalis 9 grams, Concha Meretricis seu Cyclinae 16 grams, Radix Trichosanthis 12 grams, Fructus Gardeniae 15 grams, Rhizoma Cynanchi Stauntonii 15 grams, Radix Peucedani 14 grams, Radix Asteris 16 grams, Cortex Magnoliae Officinalis 6 grams, Fructus Mume 15 grams, Folium Eriobotryae 25 grams, the Radix Stemonae 12 grams, Cortex Mori 12 grams, Radix Asparagi 10 grams, the Rhizoma Anemarrhenae 8 grams, Radix Platycodonis 15 grams, Caulis Bambusae In Taenia 8 grams, Herba Gnaphalii Affinis 15 grams, 8 grams, Poria, Radix Polygoni Multiflori 20 grams, Pumex 8 grams.

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Cacumen Platycladi: pick clean impurity, rubs broken destemming, well sifted ash bits;

2, Semen Lepidii (Semen Descurainiae): get crude drug, removing impurity

3, Herba Spirodelae: 6-9 fishes between the month, dries;

4, Pericarpium Citri Reticulatae Viride: pick clean impurity, be soaked in water, pull out, run through, section, dries;

5, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

6, Semen Arecae: pick decontamination, soaks with clear water, changes water, to soaking, pick up by temperature situation, and section, dries;

7, Radix Et Rhizoma Rhei: pick clean impurity, size stepping, moistening is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;

8, Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;

9, Herba Ephedrae: pick decontamination, removes most woody stems and undesirable root, washes, cutting after micro-profit, dry;

10, Semen Armeniacae Amarum: pick clean impurity, put in boiling water and slightly boil, pulls out when crust micro-wrinkle, in leaching cold water, sloughs seed coat, dries, and winnows with a dustpan clean;

11, Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter;

12, Radix Glycyrrhizae: extracting liquorice sheet, the Mel and the boiled water that add refining heat are a little, mix thoroughly, slightly vexed, and put in pot and fry to deepening yellow with slow fire, till tack-free, taking-up cools, 100 jin, every Radix Glycyrrhizae, with cooked Mel 25-30 jin;

13, Herba Asari: Ex-all impurity, by water spray profit, timely cutting, dries;

14, Fructus Perillae: dedust of winnowing with a dustpan is considered to be worth doing, cleans, dries;

15, Semen Sinapis Albae: former medicine is winnowed with a dustpan most impurity, and fry to buff, micro-have fragrance and get final product;

16, Fructus Arctii: pick decontamination, sieve removes spare;

17, Pericarpium Trichosanthis: get crude drug, removing fruit stem and impurity, wash quickly is clean, runs through, shredding, dry, and sieve removes chip;

18, Rhizoma Belamcandae: pick decontamination, water is cleaned, and slightly soaks, pulls out, run through, and section, dries, and sieve goes must, consider to be worth doing;

19, Indigo Naturalis: pick decontamination, crosses square-bottomed bamboo basket;

20, Concha Meretricis seu Cyclinae: clean, dry, be ground into fragment;

21, Radix Trichosanthis: pick decontamination, size block is separately, saturating with blister about sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, pull out, shine extremely dry, be pounded fritter;

22, Fructus Gardeniae: sieve dedust bits, pick decontamination, pulverize and sieve or cut off two ends;

23, Rhizoma Cynanchi Stauntonii: pick decontamination, cleans earth, pulls out, run through, cutting, dry after slightly soaking;

24, Radix Peucedani: get crude drug, removing impurity, cleans, runs through, shave, dry or cold drying, and sieve removes chip;

25, Radix Asteris: pick decontamination, removes residual stem, and clean, slightly moistening, is cut into segment, dries;

26, Cortex Magnoliae Officinalis: be soaked in water and pull out, scrapes off rough bark after running through, and clean, shredding, dries;

27, Fructus Mume: pick clean impurity, sieve dedust bits, clean, dry;

28, Folium Eriobotryae: brush away fine hair, washes, and slightly moistens, and shredding is dried;

29, the Radix Stemonae: pick clean impurity, removing fibrous root, cleans, runs through rear cutting, dry;

30, Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;

31, Radix Asparagi: pick decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, drying;

32, the Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

33, Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;

34, Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting

35, Herba Gnaphalii Affinis: gather when blooming, dries, and removes most impurity;

36, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;

37, Radix Polygoni Multiflori: pick decontamination, cleans, saturating with blister to eighty per cant, pulls out, and profit is even to inside and outside humidity, and section or dice, dry;

38, Pumex: clean and dry, smash;

Two, prepare

Preparation method: the Cacumen Platycladi that (1) will cook, Semen Lepidii (Semen Descurainiae), Herba Spirodelae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Semen Arecae, Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Herba Asari, Fructus Perillae, Semen Sinapis Albae, Fructus Arctii, Pericarpium Trichosanthis, Rhizoma Belamcandae, Indigo Naturalis, Concha Meretricis seu Cyclinae, Radix Trichosanthis, Fructus Gardeniae, Rhizoma Cynanchi Stauntonii, Radix Peucedani, Radix Asteris, Cortex Magnoliae Officinalis, Fructus Mume, Folium Eriobotryae, the Radix Stemonae, Cortex Mori, Radix Asparagi, the Rhizoma Anemarrhenae, Radix Platycodonis, Caulis Bambusae In Taenia, Herba Gnaphalii Affinis, Poria, Radix Polygoni Multiflori, Pumex grinds as fine powder mixing and stirring crosses 200 order dusting covers; (2) Mel is refined into the tender honey of 110-115 DEG C; (3) by grind for fine powder spice by weight the ratio of 1:1 add mixing system in Mel and stick together, then rubbing pill, 3 grams, every ball.

Medicine of the present invention has expelling phlegm for arresting cough, the function of heat clearing away of relievining asthma, and is used for the treatment of infantile pertussis instant effect, good effect, does not recur.

In prescription, Semen Lepidii (Semen Descurainiae) has eliminating pathogen from the lung for relieving asthma, and inducing diuresis to remove edema is monarch drug, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, and Semen Armeniacae Amarum expelling phlegm for arresting cough, relievings asthma, intestine moistening, and the two is ministerial drug; Three taste medicines play the effect of heat-clearing and toxic substances removing, lung moistening, pathogenic fire reducing jointly, and with lung heat clearing stomach function regulating, drying dampness to eliminate phlegm, cough-relieving is that master can be effected a permanent cure; Rhizoma Zingiberis Recens is delivered, cold expelling, preventing or arresting vomiting, and opening expectorant is adjuvant drug, Radix Glycyrrhizae has and middle emergency, lung moistening, removing toxic substances, and coordinating the actions of various ingredients in a prescription is for making medicine, all medicines take stopgap measures with being left, and said medicine combined, and makes it efficacy of drugs and produce synergism, thus effectively can treat the recurrence of infantile pertussis.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, be divided into two groups, wherein one group is overdose, and another group is normal amount, take pill overdose group 0.25g/kg, normal amount group 0.15g/kg, adopts the administration of dilution administration by gavage, every twice-daily, take 7 days continuously, observation administration is reacted, and result shows that rabbit is movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept children in out-patient clinic patient totally 30 examples for medical treatment.

2, diagnostic criteria

Have in 1 ~ 2 week before onset and infantile pertussis infant contact history, child is common.Fall ill more slow, sick just have low grade fever and cold symptoms, and cough increases the weight of gradually, and night be acute, occurs a succession of paroxysmal spasmodic cough of paroxysmal and with inspiratory croup, recurrent exerbation, though cough weighs and the many absence of signs of pulmonary after 1 week.Leukocyte showed increased, often reach (30 ~ 50) × 10 [9]/L, lymphocyte is up to more than 0.50 ~ 0.70.

3, Therapeutic Method

Every day respectively takes 1 ball, 7 days courses for the treatment of sooner or later, serve on 2 courses for the treatment of.

4, efficacy assessment standard

Effective: infantile pertussis transference cure, recovery from illness.

Take a turn for the better: infantile pertussis symptom alleviates, and fever and cough progressively takes a turn for the better.

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

In above-mentioned treatment, by Drug therapy later stage infantile pertussis patient 30 example of the present invention, effective 25 examples of result, obvious effective rate is 83.33%, and total effective rate is 93.33%.

Claims (3)

1. treat the medicine of infantile pertussis for one kind, it is characterized in that: it is made up of the crude drug in following weight range: Cacumen Platycladi 40-50 gram, Semen Lepidii (Semen Descurainiae) 30-40 gram, Herba Spirodelae 40-60 gram, Pericarpium Citri Reticulatae Viride 35-45 gram, Pericarpium Citri Reticulatae 30-50 gram, Semen Arecae 5-8 gram, Radix Et Rhizoma Rhei 10-20 gram, Rhizoma Zingiberis Recens 8-12 gram, Herba Ephedrae 4-6 gram, Semen Armeniacae Amarum 40-60 gram, Gypsum Fibrosum 20-30 gram, Radix Glycyrrhizae 8-12 gram, Herba Asari 4-6 gram, Fructus Perillae 30-40 gram, Semen Sinapis Albae 8-12 gram, Fructus Arctii 10-15 gram, Pericarpium Trichosanthis 20-30 gram, Rhizoma Belamcandae 15-20 gram, Indigo Naturalis 8-10 gram, Concha Meretricis seu Cyclinae 15-20 gram, Radix Trichosanthis 10-15 gram, Fructus Gardeniae 10-20 gram, Rhizoma Cynanchi Stauntonii 10-20 gram, Radix Peucedani 12-16 gram, Radix Asteris 14-18 gram, Cortex Magnoliae Officinalis 5-8 gram, Fructus Mume 10-20 gram, Folium Eriobotryae 20-30 gram, Radix Stemonae 10-15 gram, Cortex Mori 10-15 gram, Radix Asparagi 8-12 gram, Rhizoma Anemarrhenae 6-12 gram, Radix Platycodonis 10-20 gram, Caulis Bambusae In Taenia 6-10 gram, Herba Gnaphalii Affinis 10-20 gram, Poria 6-10 gram, Radix Polygoni Multiflori 15-25 gram, Pumex 6-10 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Cacumen Platycladi 45 grams, Semen Lepidii (Semen Descurainiae) 35 grams, 50 grams, Herba Spirodelae, 40 grams, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae 40 grams, Semen Arecae 6 grams, Radix Et Rhizoma Rhei 15 grams, 10 grams, Rhizoma Zingiberis Recens, 4 grams, Herba Ephedrae, 50 grams, Semen Armeniacae Amarum, 25 grams, Gypsum Fibrosum, 10 grams, Radix Glycyrrhizae, Herba Asari 4 grams, Fructus Perillae 30 grams, Semen Sinapis Albae 10 grams, Fructus Arctii 12 grams, Pericarpium Trichosanthis 25 grams, Rhizoma Belamcandae 16 grams, Indigo Naturalis 9 grams, Concha Meretricis seu Cyclinae 16 grams, Radix Trichosanthis 12 grams, Fructus Gardeniae 15 grams, Rhizoma Cynanchi Stauntonii 15 grams, Radix Peucedani 14 grams, Radix Asteris 16 grams, Cortex Magnoliae Officinalis 6 grams, Fructus Mume 15 grams, Folium Eriobotryae 25 grams, the Radix Stemonae 12 grams, Cortex Mori 12 grams, Radix Asparagi 10 grams, the Rhizoma Anemarrhenae 8 grams, Radix Platycodonis 15 grams, Caulis Bambusae In Taenia 8 grams, Herba Gnaphalii Affinis 15 grams, 8 grams, Poria, Radix Polygoni Multiflori 20 grams, Pumex 8 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Cacumen Platycladi: pick clean impurity, rubs broken destemming, well sifted ash bits;

(2) Semen Lepidii (Semen Descurainiae): get crude drug, removing impurity

(3) Herba Spirodelae: 6-9 fishes between the month, dries;

(4) Pericarpium Citri Reticulatae Viride: pick clean impurity, be soaked in water, pull out, run through, section, dries;

(5) Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

(6) Semen Arecae: pick decontamination, soaks with clear water, changes water, to soaking, pick up by temperature situation, and section, dries;

(7) Radix Et Rhizoma Rhei: pick clean impurity, size stepping, moistening is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;

(8) Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;

(9) Herba Ephedrae: pick decontamination, removes most woody stems and undesirable root, washes, cutting after micro-profit, dry;

(10) Semen Armeniacae Amarum: pick clean impurity, put in boiling water and slightly boil, pulls out when crust micro-wrinkle, in leaching cold water, sloughs seed coat, dries, and winnows with a dustpan clean;

(11) Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter;

(12) Radix Glycyrrhizae: extracting liquorice sheet, the Mel and the boiled water that add refining heat are a little, mix thoroughly, slightly vexed, and put in pot and fry to deepening yellow with slow fire, till tack-free, taking-up cools, 100 jin, every Radix Glycyrrhizae, with cooked Mel 25-30 jin;

(13) Herba Asari: Ex-all impurity, by water spray profit, timely cutting, dries;

(14) Fructus Perillae: dedust of winnowing with a dustpan is considered to be worth doing, cleans, dries;

(15) Semen Sinapis Albae: former medicine is winnowed with a dustpan most impurity, and fry to buff, micro-have fragrance and get final product;

(16) Fructus Arctii: pick decontamination, sieve removes spare;

(17) Pericarpium Trichosanthis: get crude drug, removing fruit stem and impurity, wash quickly is clean, runs through, shredding, dry, and sieve removes chip;

(18) Rhizoma Belamcandae: pick decontamination, water is cleaned, and slightly soaks, pulls out, run through, and section, dries, and sieve goes must, consider to be worth doing;

(19) Indigo Naturalis: pick decontamination, crosses square-bottomed bamboo basket;

(20) Concha Meretricis seu Cyclinae: clean, dry, be ground into fragment;

(21) Radix Trichosanthis: pick decontamination, size block is separately, saturating with blister about sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, pull out, shine extremely dry, be pounded fritter;

(22) Fructus Gardeniae: sieve dedust bits, pick decontamination, pulverize and sieve or cut off two ends;

(23) Rhizoma Cynanchi Stauntonii: pick decontamination, cleans earth, pulls out, run through, cutting, dry after slightly soaking;

(24) Radix Peucedani: get crude drug, removing impurity, cleans, runs through, shave, dry or cold drying, and sieve removes chip;

(25) Radix Asteris: pick decontamination, removes residual stem, and clean, slightly moistening, is cut into segment, dries;

(26) Cortex Magnoliae Officinalis: be soaked in water and pull out, scrapes off rough bark after running through, and clean, shredding, dries;

(27) Fructus Mume: pick clean impurity, sieve dedust bits, clean, dry;

(28) Folium Eriobotryae: brush away fine hair, washes, and slightly moistens, and shredding is dried;

(29) Radix Stemonae: pick clean impurity, removing fibrous root, cleans, runs through rear cutting, dry;

(30) Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;

(31) Radix Asparagi: pick decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, drying;

(32) Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

(33) Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;

(34) Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting

(35) Herba Gnaphalii Affinis: gather when blooming, dries, and removes most impurity;

(36) Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;

(37) Radix Polygoni Multiflori: pick decontamination, cleans, saturating with blister to eighty per cant, pulls out, and profit is even to inside and outside humidity, and section or dice, dry;

(38) Pumex: clean and dry, smash;

(2) prepare

Preparation method: the Cacumen Platycladi that (1) will cook, Semen Lepidii (Semen Descurainiae), Herba Spirodelae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Semen Arecae, Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Herba Asari, Fructus Perillae, Semen Sinapis Albae, Fructus Arctii, Pericarpium Trichosanthis, Rhizoma Belamcandae, Indigo Naturalis, Concha Meretricis seu Cyclinae, Radix Trichosanthis, Fructus Gardeniae, Rhizoma Cynanchi Stauntonii, Radix Peucedani, Radix Asteris, Cortex Magnoliae Officinalis, Fructus Mume, Folium Eriobotryae, the Radix Stemonae, Cortex Mori, Radix Asparagi, the Rhizoma Anemarrhenae, Radix Platycodonis, Caulis Bambusae In Taenia, Herba Gnaphalii Affinis, Poria, Radix Polygoni Multiflori, Pumex grinds as fine powder mixing and stirring crosses 200 order dusting covers; (2) Mel is refined into the tender honey of 110-115 DEG C; (3) by grind for fine powder spice by weight the ratio of 1:1 add mixing system in Mel and stick together, then rubbing pill, 3 grams, every ball.