CN103611145B

CN103611145B - Medicament for treating simple struma and preparation method thereof

Info

Publication number: CN103611145B
Application number: CN201310680388.XA
Authority: CN
Inventors: 苏振华
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-12-16
Filing date: 2013-12-16
Publication date: 2015-07-08
Anticipated expiration: 2033-12-16
Also published as: CN103611145A

Abstract

The invention discloses a medicament for treating simple struma and a preparation method thereof. The medicament is mainly prepared from bryozoatum, leech and pangolin in a certain weight ratio. The medicament disclosed by the invention has the functions of depressing qi, warming the middle warmer, warming the kidney, absorbing qi, softening hard mass and treating stranguria, and has the advantages of quick response, good curative effect and no relapse of cured simple struma when being used for treating simple struma.

Description

A kind of medicine for the treatment of simple goiter and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of simple goiter and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Simple goiter is the compensatory thyromegaly caused by the reasons such as iodine deficiency, goitrogen or relevant enzyme defect, without obvious hyperthyroidism or go down, therefore also known as nontoxic goiter, be characterized in distributing in non-Goiter Endemic district, and without tumor and inflammation, course of disease initial stage thyroid mostly is anthorisma, the enlargement of many nodositas can be developed into later, oppression state can be there is to adjacent tissue's organ, as dyspnea, dysphagia etc.Because current Western medicine effectively cannot treat simple goiter, therefore there is great demand in the Chinese medicine of people to rapid, effective treatment simple goiter, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment simple goiter, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment simple goiter.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Pumex, Hirudo, Squama Manis, Flos Carthami, Rhizoma Zingiberis medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat simple goiter.Wherein select Pumex to be because its nature and flavor are salty-cold, enter lung, stomach warp, have lung heat clearing fire, change old expectorant, softening the hard mass, treating stranguria function, control expectorant dyspnea of heat type and cough, old accumulation of phlegm block, goiter, scrofula, hernia, skin ulcer swells, corneal nebula.Select Hirudo to be because the salty hardship of its nature and flavor, flat, poisonous, enter liver, urinary bladder channel, have removing blood stasis, removing blood stasis, the function of stimulating the menstrual flow, control blood-retention ， mass in the abdomen, gather, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, conjunctival congestion with ophthalmalgia, nebula.Select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, have the routed carbuncle of detumescence, search wind active, the function of stimulating milk secretion of stimulating the menstrual flow, control carbuncle skin ulcer and swell, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external is stopped blooding.Select Flos Carthami to be that temperature, enters the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea ， mass in the abdomen because its nature and flavor are pungent, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Rhizoma Zingiberis to be that heat, enters spleen, stomach, lung meridian because its nature and flavor are pungent, have warming middle-JIAO by cold, the function that recuperating depleted YANG is promoted blood circulation, controls trusted subordinate's cold type of pain, vomits and diarrhoea, cold extremities faint pulse, and cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, and yang deficiency is told, be defeated in battle, hematochezia.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight

Pumex 10-20 gram of Hirudo 8-15 gram of Squama Manis 6-12 gram

Flos Carthami 15-25 gram of Rhizoma Zingiberis 10-18 gram

Be preferably

Pumex 15 grams of Hirudos 10 grams of Squama Maniss 10 grams

Flos Carthami 20 grams of Rhizoma Zingiberiss 15 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Pumex: clean and dry, pulverize;

2, Hirudo: clean, vexed soft, cutting, dries;

3, Squama Manis: get the Squama Manis sheet picking clean, separately size, separately puts sand in pot and makes popular, add Squama Manis sheet, frying to heaving in time golden yellow, taking out, and sieve shakeout, cools;

4, Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;

5, Rhizoma Zingiberis: pick clean impurity, is soaked in water 3-6 hours, pulls out, cuts into slices or dices, dry after moistening.

Two, prepare

1, the Pumex of described weight, Hirudo, Squama Manis, Flos Carthami, Rhizoma Zingiberis are decocted with water twice, first time adds water 6 times amount, and intense fire decocts boiling 10 minutes, then uses slow fire boiling 25 minutes, filter first time decoction liquor.

2, add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor.

3, merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into two doses to take.

Medicine of the present invention has sending down the abnormal ascending QI warming middle-JIAO, the function of warming the kidney improving inspiration by invigorating kidney-QI, is used for the treatment of simple goiter instant effect, good effect.Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 100 examples for medical treatment.

2, diagnostic criteria

The course of disease is that diffuse goiter is large in early days, to have a medical check-up visible enlargement thyroid smooth surface, matter is soft, up and down with swallowing, atremia and vascular murmur, along with the development of the course of disease, engender thyroid nodule enlargement, be generally unsymmetry, the multiple tuberosity of many nodositas can flock together, show as neck region lump.Tuberosity differs in size, quality not etc., position differs.Goiter is general without pain, as nodosity internal hemorrhage then can occur pain.As health check-up finds that the hard mobility of thyroid nodule matter is not good enough, the possibility that cancerates should be watched out for.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, every day, potion, 10 days was a course for the treatment of, took 2 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: simple goiter symptom is fully recovered, recover normal;

Take a turn for the better: simple goiter symptom alleviates, and the state of an illness progressively takes a turn for the better;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

In above-mentioned treatment, by Drug therapy simple goiter patient 100 example of the present invention, effective 83 examples of result, obvious effective rate is 83%, and take a turn for the better 5 examples, and improvement rate is 5%, and invalid 12 examples, total effective rate is 88%.

Claims

1. treat a medicine for simple goiter, it is characterized in that: it is made up of the crude drug in following weight range:

Pumex 10-20 gram of Hirudo 8-15 gram of Squama Manis 6-12 gram

Flos Carthami 15-25 gram of Rhizoma Zingiberis 10-18 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Pumex 15 grams of Hirudos 10 grams of Squama Maniss 10 grams

Flos Carthami 20 grams of Rhizoma Zingiberiss 15 grams.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Pumex: clean and dry, pulverize;

(2) Hirudo: clean, vexed soft, cutting, dries;

(3) Squama Manis: get the Squama Manis sheet picking clean, separately size, separately puts sand in pot and makes popular, add Squama Manis sheet, frying to heaving in time golden yellow, taking out, and sieve shakeout, cools;

(4) Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;

(5) Rhizoma Zingiberis: pick clean impurity, is soaked in water 3-6 hours, pulls out, cuts into slices or dices, dry after moistening;

(2) prepare

(1) Pumex of described weight, Hirudo, Squama Manis, Flos Carthami, Rhizoma Zingiberis are decocted with water twice, first time adds water 6 times amount, and intense fire decocts boiling 10 minutes, then uses slow fire boiling 25 minutes, filter first time decoction liquor;

(2) add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor;

(3) merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into two doses to take.