CN103446522B

CN103446522B - Medicine for treating acid regurgitation and preparation method of medicine

Info

Publication number: CN103446522B
Application number: CN201310387670.9A
Authority: CN
Inventors: 周海侠
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-08-31
Filing date: 2013-08-31
Publication date: 2015-07-01
Anticipated expiration: 2033-08-31
Also published as: CN103446522A

Abstract

The invention discloses a medicine for treating acid regurgitation and a preparation method of medicine. The medicine is mainly prepared from fructus amomi, myristica, hawthorn, medicated leaven, fructus aurantii and areca-nut according to a certain weight ratio. The medicine disclosed by the invention has the functions of tonifying spleen and harmonizing stomach, helping digestion and regulating middle energizer, relaxing muscle and clearing heat, and is used for treating acid regurgitation with fast effect and high cure rate.

Description

A kind of medicine for the treatment of acid regurgitation and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of acid regurgitation and preparation method thereof, belong to the field of Chinese medicines.

Technical background

All sour waters all by upper general in stomach, if do not swallow person immediately, are called acid regurgitation; Do not swallow and the person of spuing, then claim acid regurgitation.In general, acid regurgitation is the symptom of general acid regurgitation water, often sees with stomachache is double, but also can occur separately.Be common in the peptic ulcer disease of doctor trained in Western medicine, chronic gastritis and dyspepsia etc.Because Western medicine effectively cannot treat acid regurgitation, and long-term taking Western medicine has more side effect, and therefore, the Chinese medicine of people to effectively treatment acid regurgitation exists very large demand.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment acid regurgitation, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating acid regurgitation.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Fructus Amomi, Rou Dou Kou, Fructus Crataegi, Massa Medicata Fermentata, Fructus Aurantii, Semen Arecae, Radix Platycodonis, Rhizoma Atractylodis, Cortex Cinnamomi, Rhizoma Coptidis, Radix Glycyrrhizae, Gypsum Fibrosum medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of acid regurgitation.Wherein select Fructus Amomi to be that temperature, enters spleen, stomach warp because its nature and flavor are pungent, in having circulation of qi promoting to adjust, stomach function regulating, the function of being amusing, control stomachache painful abdominal mass swollen, anorexia dyspepsia, chokes every vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.Select meat bean Kou to be that temperature, enters spleen, large intestine channel, have warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, help digestion, Gu the function of intestinal, control trusted subordinate's distending pain, diarrhea of deficiency type cold-dysentery because its nature and flavor are pungent, vomiting, dyspepsia does not disappear.Select Fructus Crataegi be because its nature and flavor acid sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate.Select Massa Medicata Fermentata to be because its nature and flavor sweet, acrid, warm, enter upright stone tablet, stomach warp, have invigorating the spleen and regulating the stomach, the function helped digestion in adjusting, controls retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, and postnatal blood stasis is suffered from abdominal pain, and children's's enlarged abdomen heavily fortified point is long-pending.Fructus Aurantii is selected to be because its nature and flavor toil, cool, enter lung, spleen, large intestine channel, have dispelling the stagnated QI, row expectorant, the function of removing food stagnancy, control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Select Semen Arecae to be because its nature and flavor toil, temperature, enters spleen, stomach, large intestine channel, has parasite killing, removing mass, the therapeutic method to keep the adverse QI flowing downwards, the function of row water, control malnutrition due to parasitic infestation, dyspepsia, abdominal distention, and heavy after dysentery, malaria, edema, beriberi, accumulation of phlegm in the hypochondrium ， Disorder ties.Select Radix Platycodonis to be because its nature and flavor toil, flat, enter lung, stomach warp, have out lung qi dispersing gas, the function of evacuation of pus of eliminating the phlegm, controls exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, and dysentery is suffered from abdominal pain.Rhizoma Atractylodis are selected to be that temperature, enters spleen, stomach warp, have spleen invigorating, dampness, resolving depression, ward off dirty function because its nature and flavor are worked hard, control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Select Cortex Cinnamomi to be because its property acrid-sweet flavor, heat, enters kidney, spleen, urinary bladder channel, has complement sun, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation, controls decline of the fire from the gate of life, cold extremities faint pulse, and YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Rhizoma Coptidis is selected to be because its nature and flavor are bitter, cold, enter the heart, liver, stomach, large intestine channel, have pathogenic fire purging, dampness, removing toxic substances, the function of parasite killing, row pyretic toxicity, typhoid fever when controlling, intenseness of heat is vexed, feeling of fullness vomiting, bacillary dysentery, and diarrhea of heat type is suffered from abdominal pain, pulmonary tuberculosis, tells, is defeated in battle, hematochezia, quenches one's thirst, infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.Select Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, processs use, controls weakness of the spleen and stomach, lack of appetite, stomachache loose stool, and overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus ， Jing Epilepsy; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Gypsum Fibrosum is selected to be because its property acrid-sweet flavor, cold, enter lung, stomach warp, raw with there being expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst, controls calentura high fever and does not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue, forges deposited promoting tissue regeneration and ulcer healing, external treatment ulcer sores, bursts and does not regain, the burning hot wound of soup.

Detailed description of the invention

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Fructus Amomi 8-15 gram of Rou Dou Kou 8-15 Keshan short, bristly hair or beard 8-15 gram

Massa Medicata Fermentata 8-15 gram of Fructus Aurantii 8-15 gram of Semen Arecae 8-15 gram

Radix Platycodonis 8-15 gram of Rhizoma Atractylodis 8-15 gram of Cortex Cinnamomi 10-20 gram

Rhizoma Coptidis 8-15 gram of Radix Glycyrrhizae 10-20 gram of Gypsum Fibrosum 8-15 gram

Preferable amount is

Fructus Amomi 10 grams of Rou Dou Kou 10 Keshan short, bristly hair or beards 10 grams

Massa Medicata Fermentata 10 grams of Fructus Aurantiis 10 grams of Semen Arecaes 10 grams

Radix Platycodonis 10 grams of Rhizoma Atractylodis 10 grams of Cortex Cinnamomis 15 grams

10 grams, Rhizoma Coptidis 10 grams of Radix Glycyrrhizaes 15 grams of Gypsum Fibrosum

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Fructus Amomi: pick decontamination and shell, smash to pieces;

2, meat bean Kou: get crude drug, removing impurity, the used time smashs to pieces;

3, Fructus Crataegi: pick clean impurity, sieve enucleation;

4, Massa Medicata Fermentata: get wheat bran and sprinkle evenly in hot pot, treated cigarette, Massa Medicata Fermentata is poured into, fry to yellow, take out, sieve removes wheat bran, cools;

5, Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and cuts into slices, dry when can pinch doubling with hands;

6, Semen Arecae: pick decontamination, soaks with clear water, changes water, to soaking, pick up by temperature situation, and section, dries;

7, Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;

8, Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;

9, Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, infiltrates a moment by warm water, and section, dries;

10, Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;

11, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;

12, Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter.

Two, prepare

1, the Fructus Amomi of described weight, Rou Dou Kou, Fructus Crataegi, Massa Medicata Fermentata, Fructus Aurantii, Semen Arecae, Radix Platycodonis, Rhizoma Atractylodis, Cortex Cinnamomi, Rhizoma Coptidis, Radix Glycyrrhizae, Gypsum Fibrosum are decocted with water, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.

2, add water medicinal residues after first time filtration 4 times amount, decocts boiling, then use slow fire boiling 20 minutes, filter and to obtain second time decoction liquor.

3, by twice decoction liquor mix homogeneously, 3 doses are divided into take.

Medicine of the present invention has invigorating the spleen and regulating the stomach, helps digestion in adjusting, the therapeutic method to keep the adverse QI flowing downwards, the effect helped digestion, and treatment acid regurgitation instant effect, short treating period, do not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.3kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient 200 example for medical treatment.

2, diagnostic criteria

Acid regurgitation water by upper general in stomach, or is swallowed immediately, or is feature by the symptom such as to spue in mouth.Often see with stomachache, heating installation etc. are double.Assertive evidence is many by depression of liver-QI, disorder of stomach-QI and sending out, and this is pathogenetic emphasis.Wherein there is difference that is partially cold, partial heat.Belong to hot person, how to be caused by depressed liver and heat transmission; Belong to cold person, stomach can be violated by cold-evil, or ferritic Deficiency and coldness of spleen and stomach forms; The rotten person of pantothenic acid of retention of food and drink is by the event of intemperance in eating damaging the spleen and stomach.

(1) cold syndrome: when doing during acid regurgitation only, breast gastral cavity feeling of distension and oppression, the smelly corruption of belch, spitting repeatedly saliva foam, diet happiness heat, extremity are not warm, lassitude and weak, and large loose stool is thin, light red tongue, white and thin fur, the many stringy and rolling pulse of arteries and veins.Control suitable warming spleen and stomach for dispelling cold, stomach function regulating antacid, replenishing vital QI with drugs of warm nature taste.White snail shell, Concha Arcae etc. can be added with acid suppression stomach function regulating.

(2) heat syndrome: do during acid regurgitation, smelly rotten gas, gastral cavilty is satisfied vexed, defecates smelly dirty, thirsty, or susceptible to lose temper due to restlessness, and two side of body distending pains, red tongue, yellow fur is thick, the many stringy and rapid pulse of arteries and veins.Control and should let out liver stomach function regulating, dispersing the stagnated pathogen with pungent drugs and lowering the adverse QI with bitter drugs.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 5 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: acid regurgitation is eliminated, without recurring after observing half a year;

Take a turn for the better: acid regurgitation symptom is clearly better;

Invalid: symptom, without improvement, does not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, by Drug therapy acid regurgitation patient 200 example of the present invention, effective 192 examples of result, obvious effective rate is 96%, and take a turn for the better 5 examples, and improvement rate is 2.5%, and invalid 3 examples, total effective rate is 98.5%.

Claims

1. treat a medicine for acid regurgitation, it is characterized in that: it is made up of the crude drug in following weight range:

Rhizoma Coptidis 8-15 gram of Radix Glycyrrhizae 10-20 gram of Gypsum Fibrosum 8-15 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

10 grams, Rhizoma Coptidis 10 grams of Radix Glycyrrhizaes 15 grams of Gypsum Fibrosum.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Fructus Amomi: pick decontamination and shell, smash to pieces;

(2) meat bean Kou: get crude drug, removing impurity, the used time smashs to pieces;

(3) Fructus Crataegi: pick clean impurity, sieve enucleation;

(4) Massa Medicata Fermentata: get wheat bran and sprinkle evenly in hot pot, treated cigarette, Massa Medicata Fermentata is poured into, fry to yellow, take out, sieve removes wheat bran, cools;

(5) Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and cuts into slices, dry when can pinch doubling with hands;

(6) Semen Arecae: pick decontamination, soaks with clear water, changes water, to soaking, pick up by temperature situation, and section, dries;

(7) Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;

(8) Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;

(9) Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, infiltrates a moment by warm water, and section, dries;

(10) Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;

(11) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;

(12) Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter;

(2) prepare

(1) Fructus Amomi of described weight, Rou Dou Kou, Fructus Crataegi, Massa Medicata Fermentata, Fructus Aurantii, Semen Arecae, Radix Platycodonis, Rhizoma Atractylodis, Cortex Cinnamomi, Rhizoma Coptidis, Radix Glycyrrhizae, Gypsum Fibrosum are decocted with water, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;

(2) add water medicinal residues after first time filtration 4 times amount, decocts boiling, then use slow fire boiling 20 minutes, filter and to obtain second time decoction liquor;

(3) by twice decoction liquor mix homogeneously, 3 doses are divided into take.