CN103611145A

CN103611145A - Medicament for treating simple struma and preparation method thereof

Info

Publication number: CN103611145A
Application number: CN201310680388.XA
Authority: CN
Inventors: 苏振华
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-12-16
Filing date: 2013-12-16
Publication date: 2014-03-05
Anticipated expiration: 2033-12-16
Also published as: CN103611145B

Abstract

The invention discloses a medicament for treating simple struma and a preparation method thereof. The medicament is mainly prepared from bryozoatum, leech and pangolin in a certain weight ratio. The medicament disclosed by the invention has the functions of depressing qi, warming the middle warmer, warming the kidney, absorbing qi, softening hard mass and treating stranguria, and has the advantages of quick response, good curative effect and no relapse of cured simple struma when being used for treating simple struma.

Description

A kind of medicine for the treatment of simple goiter and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of simple goiter and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Simple goiter is due to the compensatory thyromegaly due to the reasons such as iodine deficiency, goitrogen or relevant enzyme defect, without obvious hyperthyroidism or go down, therefore claim again nontoxic goiter, be characterized in distributing Yu Fei Goiter Endemic district, and without tumor and inflammation, course of disease initial stage thyroid mostly is anthorisma, can develop into the enlargement of many nodositas later, there is oppression state in Ke Dui adjacent tissue organ, as dyspnea, and dysphagia etc.Because current Western medicine cannot effectively be treated simple goiter, so there is great demand to the Chinese medicine of rapid, effective treatment simple goiter in people, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, has finally found the medicine of effective treatment simple goiter, thereby has completed the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment simple goiter.

Another object of the present invention has just been to provide the preparation method of this Chinese medicine composition.

Medicine of the present invention is to select Pumex, Hirudo, Squama Manis, Flos Carthami, Rhizoma Zingiberis medicine to combine preparation, makes each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat simple goiter.Wherein select Pumex to be because its nature and flavor are salty-cold, enter lung, stomach warp, have lung heat clearing fire, change old expectorant, softening the hard mass, treating stranguria function, controls expectorant dyspnea of heat type and coughs, old accumulation of phlegm piece, goiter, scrofula, hernia, skin ulcer is swollen, corneal nebula.Select Hirudo to be because the salty hardship of its nature and flavor is flat, poisonous, enter liver, urinary bladder channel, have removing blood stasis, removing blood stasis, the function of stimulating the menstrual flow, controls blood-retention ， mass in the abdomen, gathers, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, conjunctival congestion with ophthalmalgia, nebula.Select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, have the routed carbuncle of detumescence, search wind active, the function of the stimulating milk secretion of stimulating the menstrual flow, controls carbuncle skin ulcer swollen, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external hemostasis.Select Flos Carthami to be because its nature and flavor are pungent, temperature, enters the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Rhizoma Zingiberis to be because its nature and flavor are pungent, heat, enters spleen, stomach, lung meridian, has warming middle-JIAO by cold, and the function that recuperating depleted YANG is promoted blood circulation, controls trusted subordinate's cold type of pain, vomit and diarrhoea, and cold extremities faint pulse, cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, yang deficiency is told, nosebleed, hematochezia.

The specific embodiment

The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight

Pumex 10-20 gram of Hirudo 8-15 gram of Squama Manis 6-12 gram

Flos Carthami 15-25 gram of Rhizoma Zingiberis 10-18 gram

Be preferably

10 grams of 10 grams of Squama Maniss of 15 grams of Hirudos of Pumex

15 grams of 20 grams of Rhizoma Zingiberiss of Flos Carthami

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Pumex: clean and dry, pulverize;

2, Hirudo: clean, vexed soft, cutting, dries;

3, Squama Manis: get the Squama Manis sheet of choosing clean, separately size, separately puts sand in pot and make popular, adds Squama Manis sheet, fries to heaving while being golden yellow, takes out, and sieve shakeout, cools;

4, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

5, Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices after moistening or dice, dry.

Two, preparation

1, the Pumex of described weight, Hirudo, Squama Manis, Flos Carthami, Rhizoma Zingiberis are decocted with water to twice, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, then uses slow fire boiling 25 minutes, filters to obtain decoction liquor for the first time.

2, the medicinal residues after filtering are for the first time added to 4 times of amounts of water, intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters to obtain decoction liquor for the second time.

3, merge decoction liquor twice, intense fire boils, then uses slow fire boiling 10 minutes, is divided into two doses and takes.

Medicine of the present invention has sending down the abnormal ascending QI warming middle-JIAO, and the function of warming the kidney improving inspiration by invigorating kidney-QI is used for the treatment of simple goiter instant effect, good effect.By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get 30 of West Germany rabbits, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 100 examples for medical treatment.

2, diagnostic criteria

The course of disease is that diffuse goiter is large in early days, the visible enlargement thyroid smooth surface of having a medical check-up, matter is soft, up and down with swallowing, atremia and vascular murmur, along with the development of the course of disease, engender thyroid nodule enlargement, be generally unsymmetry, a plurality of tuberositys of many nodositas can flock together, and show as neck region lump.Tuberosity differs in size, quality not etc., position differs.Goiter is generally without pain, as nodosity internal hemorrhage can occur pain.As health check-up, find that the hard mobility of thyroid nodule matter is not good enough, should watch out for the possibility that cancerates.

3, Therapeutic Method

Select above-mentioned medicament, to patient, take, every day, potion, 10 days was a course for the treatment of, took continuously 2 courses for the treatment of.

4, efficacy assessment standard

Effective: the recovery from illness of simple goiter symptom, recovers normal;

Take a turn for the better: simple goiter symptom alleviates, and the state of an illness progressively takes a turn for the better;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

In above-mentioned treatment, by Drug therapy simple goiter patient of the present invention 100 examples, effective 83 examples of result, obvious effective rate is 83%, 5 examples that take a turn for the better, and improvement rate is 5%, invalid 12 examples, total effective rate is 88%.

Claims

1. a medicine for the treatment of simple goiter, is characterized in that: it is to be made by the crude drug in following weight range:

Pumex 10-20 gram of Hirudo 8-15 gram of Squama Manis 6-12 gram

Flos Carthami 15-25 gram of Rhizoma Zingiberis 10-18 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

10 grams of 10 grams of Squama Maniss of 15 grams of Hirudos of Pumex

15 grams of 20 grams of Rhizoma Zingiberiss of Flos Carthami.

3. according to the preparation method of medicine described in claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Pumex: clean and dry, pulverize;

(2) Hirudo: clean, vexed soft, cutting, dries;

(3) Squama Manis: get the Squama Manis sheet of choosing clean, separately size, separately puts sand in pot and make popular, adds Squama Manis sheet, fries to heaving while being golden yellow, takes out, and sieve shakeout, cools;

(4) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

(5) Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices after moistening or dice, dry;

(2) preparation

(1) Pumex of described weight, Hirudo, Squama Manis, Flos Carthami, Rhizoma Zingiberis are decocted with water to twice, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, then uses slow fire boiling 25 minutes, filters to obtain decoction liquor for the first time;

(2) medicinal residues after filtering are for the first time added to 4 times of amounts of water, intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters to obtain decoction liquor for the second time;

(3) merge decoction liquor twice, intense fire boils, then uses slow fire boiling 10 minutes, is divided into two doses and takes.