CN103638492B

CN103638492B - Medicine for treating dysmenorrhea and preparation method of medicine

Info

Publication number: CN103638492B
Application number: CN201310661897.8A
Authority: CN
Inventors: 张朝兰
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-12-10
Filing date: 2013-12-10
Publication date: 2015-06-03
Anticipated expiration: 2033-12-10
Also published as: CN103638492A

Abstract

The invention discloses a medicine for treating dysmenorrhea and a preparation method of the medicine. The medicine is mainly prepared from corydalis tuber, scorpion, semen litchi, radix pseudostellariae, alpinia oxyphylla, pericarpium citri reticulatae viride, radix clematidis, cowherb seed, phoenix-tail fern and other medicines in a certain weight ratio. The medicine has the functions of warming middle-jiao, expelling cold, relieving convulsion and dredging collaterals, is quick in response and short in course of treatment when used for treating dysmenorrhea, and prevents relapse after healing.

Description

A kind of medicine for the treatment of dysmenorrhea and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of dysmenorrhea and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Dysmenorrhea is the common symptom of a kind of women, refers to and occurs lower abdomen spasmic pain when menstrual onset.Dysmenorrhea can be divided into again primary dysmenorrhea and secondary dysmenorrhea two kinds, primary dysmenorrhea refers to and all occurs pain repeatedly from there being dysmenorrhea to rise during menarche later at every turn, secondary dysmenorrhea refers to menophania and starts have a stage not feel pain before and after menstrual onset, progressively there is stomachache later, and aggravate gradually.At present, western medicine dysmenorrhea poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand to the Chinese medicine of effectively treating dysmenorrhea in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment dysmenorrhea, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating dysmenorrhea.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Rhizoma Corydalis, Scorpio, Semen Litchi, Radix Pseudostellariae, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae Viride, Radix Clematidis, Semen Vaccariae, Herba Pteridis Multifidae, Caulis Sargentodoxae, Retinervus Luffae Fructus, Fructus Crataegi, Semen Ginkgo, Folium Perillae, Semen Platycladi, the Radix Aucklandiae, Cortex Moutan, Stigma Croci, Oletum Trogopterori, Radix Polygoni Multiflori, Myrrha, Semen Helianthi, Herba Epimedii, Rhizoma Ligustici, Herba Solani Septemlobi, Radix Ophiopogonis, Rhizoma Zingiberis Recens, Fructus Jujubae, Carapax Trionycis, Pedicellus Cucurbitae medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of rapid, effective treatment dysmenorrhea.Rhizoma Corydalis is wherein selected to be that temperature, enter liver, stomach warp, invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, the function of pain relieving, controls all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury because its nature and flavor are worked hard.Selects the scorpion because of their sexual taste salty, flat, toxic, with functions, antispasmodic, t2dm, the function of detoxification, epilepsy, epilepsy, stroke, hemiplegia, mouth askew, migraine, rheumatism bi pain, tetanus, lymph node tuberculosis, measles sore swollen.Select Semen Litchi to be because its property sweet-puckery flavor, temperature, enter liver, kidney channel, have warming middle-JIAO, regulate the flow of vital energy, the function of pain relieving, controls gastric abscess, colicky, women's pricking caused by the stagnation of QI and blood.Radix Pseudostellariae is selected to be that tepor, enters the heart, spleen, lung three warp, have the function of tonifying the lung, spleen invigorating, control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus order antiperspirant, metal fatigue because its nature and flavor sweetness and bitterness.Select Fructus Alpiniae Oxyphyllae be because its nature and flavor pungent, temperature, enter spleen, kidney channel, have warming the spleen, warming the kidney, solid and gas, the function of arresting seminal emission, control cold air stomachache, invasion by pathogenic cold vomit and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine.Select Pericarpium Citri Reticulatae Viride to be that tepor, enters liver, gallbladder meridian, has soothing the liver dispelling the stagnated QI, the function of eliminating stagnation expectorant because its nature and flavor toil, control breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction block.Select Radix Clematidis to be because its nature and flavor are pungent salty, temperature, poisonous, enter urinary bladder channel, have wind-damp dispelling, the meridian dredging, expectorant saliva, the function of the loose hypochondriac lump, controls gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria ， lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select Semen Vaccariae to be because its nature and flavor hardship is flat, enter liver, stomach warp, have promoting the circulation of blood to stimulate the menstrual flow, expedite the emergence of stimulating milk secretion, the function of detumescence sore, controls women's amenorrhea, galactostasis, and difficult labour, stranguria with blood, carbuncle, incised wound is hemorrhage.Herba Pteridis Multifidae is selected to be that cold in nature, enter kidney, stomach two warp, have clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, the function of subduing swelling and detoxicating, controls icterohepatitis because the light micro-hardship of its nature and flavor, enteritis, bacillary dysentery, stranguria with turbid discharge, leukorrhagia, spits blood, epistaxis, have blood in stool, hematuria, tonsillitis, parotitis, carbuncle sore tumefacting virus, eczema.Caulis Sargentodoxae is selected to be that flat, enter liver, large intestine two warp, relieve internal heat eliminating carbuncle, promoting blood circulation to remove obstruction in the collateral, the function of wind dispelling insecticide, controls acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition because its nature and flavor are bitter, worm pain, injury from falling down.Retinervus Luffae Fructus is selected to be that flat, have dredge the meridian passage, the function of removing heat-phlegm, controls pain in chest and hypochondrium because its nature and flavor are sweet, stomachache, lumbago, painful and swollen testis, lung-heat productive cough, women's amenorrhea, galactostasis, carbuncle, anal fistula.Select Fructus Crataegi to be that tepor, enters spleen, stomach, Liver Channel because its nature and flavor acid is sweet, have and help digestion long-pending, dissipating blood stasis blood, drives the function of edge worm, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's also eats stagnation.Semen Ginkgo is selected to be that flat, poisonous, enter lung, kidney channel, gas of astringing the lung, relieving asthma and cough, leukorrhagia stopping is turbid, and the function of urine reducing, controls asthma, phlegmatic cough, leucorrhea, nebulousurine because its nature and flavor sweetness and bitterness is puckery, seminal emission, gonorrhea, frequent micturition.Folium Perillae is selected to be that temperature, enters lung, spleen channel, deliver, cold expelling, regulate the flow of vital energy because its nature and flavor are pungent, and the function of battalion, cure cold wind and cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen, frequent fetal movement, and can solving toxin of fish and crab.Semen Platycladi is selected to be that flat, enter the heart, liver, spleen channel, have tranquilizing by nourishing the heart, the function of loosening bowel to relieve constipation, controls palpitation with fear because its nature and flavor are sweet, insomnia, seminal emission, night sweat, the function of constipation.Select the Radix Aucklandiae to be that temperature, enters lung, liver, spleen channel, have promoting the circulation of QI to relieve pain, the function of warming middle-JIAO for easing the stomach, control the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain because its nature and flavor are worked hard, vomiting, has loose bowels, dysentery tenesmus, colic of cold type.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle ， Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Select Stigma Croci to be that flat, enter the heart, Liver Channel, have blood circulation promoting and blood stasis dispelling, the function of dispersing stagnation and relieving accumulation of pathogens, control troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed because its nature and flavor are sweet, spit blood, typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, postnatal blood stasis is suffered from abdominal pain, tumbling and swelling.Select Oletum Trogopterori to be because its property bitter but sweet flavor, temperature, enters liver, spleen channel, and raw by the function having promoting the circulation of blood pain relieving, control all pains of trusted subordinate's vim and vigour, women's amenorrhea, postnatal blood stasis is had a pain; External treatment Serpentis, scorpion, centipete bite, stir-fry is stopped blooding, and control metrorrhagia, menorrhagia, leucorrhea with bloody discharge is without cease.Radix Polygoni Multiflori is selected to be that tepor, enters liver, kidney channel, have tonifying liver, kidney tonifying, nourish blood, the function of dispeling the wind because its property bitter but sweet flavor is puckery, control hepatic and renal YIN deficiency, sending out must be early white, and blood deficiency is dizzy, and waist knee joint is weak, and muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Myrrha is selected to be that flat, enter Liver Channel, have loose blood blood stasis removing, the function of subduing swelling and relieving pain, controls and fall damage, incised wound, muscles and bones, trusted subordinate all Tong ， mass in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye because its nature and flavor are bitter.Semen Helianthi is selected to be because it controls dysentery, saturating pus of carbuncle.Select Herba Epimedii to be because its property acrid-sweet flavor, temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting, the function of expelling wind and removing dampness, control sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, and hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Rhizoma Ligustici is selected to be that temperature, returns urinary bladder channel, have cold expelling to dispel the wind, the function of removing damp and stopping pain because its nature and flavor are pungent, for anemofrigid cold, top, mountain peak pain.Herba Solani Septemlobi is selected to be because its nature and flavor are bitter, cold in nature, there is the function of heat-clearing and toxic substances removing, control laryngopharynx swelling and pain, blurred vision conjunctival congestion, skin pruritus.Select Radix Ophiopogonis to be because its property sweet and slightly bitter taste, cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, and the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, and clearly yearningly, calentura Tianjin is hindered, dry mouth and throat, constipation.Select Rhizoma Zingiberis Recens to be because its nature and flavor are pungent, temperature, enter lung, stomach, spleen channel, deliver, cold expelling, preventing or arresting vomiting, open the function of expectorant, cure cold wind and cold, vomiting, and phlegm retention, breathes with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Select Fructus Jujubae to be that temperature, enters spleen, stomach warp, have spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid because its nature and flavor are sweet, adjust battalion to defend, separate the function of poison of drug, control insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Carapax Trionycis is selected to be because its nature and flavor are salty, flat, enter liver, spleen channel, have replenishing YIN and removing heat, suppressing the hyperactive liver to relieve the wind syndrome, the function of hard masses softening and resolving, control consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN, malaria with general debility malaria with splenomegaly ， mass in the abdomen mass beside the umbilicus, amenorrhea menometrorrhagia, little Jing Epilepsy.Select Pedicellus Cucurbitae to be because it controls carbuncle and ulcer, furuncle, scald.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Rhizoma Corydalis 5-15 gram of Scorpio 5-15 gram of Semen Litchi 5-15 gram

Radix Pseudostellariae 25-35 gram of Fructus Alpiniae Oxyphyllae 10-20 gram of Pericarpium Citri Reticulatae Viride 15-25 gram

Radix Clematidis 5-15 gram of Semen Vaccariae 10-20 gram of Herba Pteridis Multifidae 10-20 gram

Caulis Sargentodoxae 3-9 gram of Retinervus Luffae Fructus 5-15 Keshan short, bristly hair or beard 5-15 gram

Semen Ginkgo 10-20 gram of Folium Perillae 5-15 gram of Semen Platycladi 5-15 gram

Radix Aucklandiae 5-15 gram of Cortex Moutan 3-9 gram of Stigma Croci 5-15 gram

Oletum Trogopterori 5-15 gram of Radix Polygoni Multiflori 10-20 gram of Myrrha 5-15 gram

Semen Helianthi 3-9 gram of Herba Epimedii 5-15 gram of Rhizoma Ligustici 5-15 gram

Herba Solani Septemlobi 5-15 gram of Radix Ophiopogonis 5-15 gram of Rhizoma Zingiberis Recens 10-20 gram

Fructus Jujubae 5-15 gram of Carapax Trionycis 5-15 gram of Pedicellus Cucurbitae 3-9 gram

Preferable amount is

Rhizoma Corydalis 10 grams of Scorpios 10 grams of Semen Litchis 10 grams

20 grams, Radix Pseudostellariae 30 grams of Fructus Alpiniae Oxyphyllae 15 grams of Pericarpium Citri Reticulatae Virides

Radix Clematidis 10 grams of Semen Vaccariae 15 grams of Herba Pteridis Multifidaes 15 grams

Caulis Sargentodoxae 6 grams of Retinervus Luffae Fructus 10 Keshan short, bristly hair or beards 10 grams

Semen Ginkgo 15 grams of Folium Perillaes 10 grams of Semen Platycladi 10 grams

The Radix Aucklandiae 10 grams of Cortex Moutans 6 grams of Stigma Crocis 10 grams

Oletum Trogopterori 10 grams of Radix Polygoni Multiflori 15 grams of Myrrhas 10 grams

Semen Helianthi 6 grams of Herba Epimedii 10 grams of Rhizoma Ligusticis 10 grams

Herba Solani Septemlobi 10 grams of Radix Ophiopogonis 10 grams of Rhizoma Zingiberis Recens 15 grams

Fructus Jujubae 10 grams of Carapax Trionycis 10 grams of Pedicellus Cucurbitaes 6 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

2, Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;

3, Semen Litchi: get crude drug, removing impurity, the used time smashs to pieces;

4, Radix Pseudostellariae: extract fibrous root, dry;

5, Fructus Alpiniae Oxyphyllae: get Fructus Alpiniae Oxyphyllae and put in pot, fry to shell burned black, take out cold, removing shell, gets core and smashs use to pieces;

6, Pericarpium Citri Reticulatae Viride: pick clean impurity, be soaked in water, pull out, run through, section, dries;

7, Radix Clematidis: pick clean impurity, removes residual stem, is soaked in water, pull out and run through, cutting, dry;

8, Semen Vaccariae: clean impurity of winnowing with a dustpan, puts in pot, takes out, cool when frying to spend six, seventy percent to popping in vain with slow fire;

9, Herba Pteridis Multifidae: the whole year can adopt, picks clean impurity, cutting, dries;

10, Caulis Sargentodoxae: be soaked in water, cleans spare, runs through, and section, dries;

11, Retinervus Luffae Fructus: clean and dry, cutting;

12, Fructus Crataegi: get and pick clean Fructus Crataegi, put in pot scorching stir-fry of useing force to outer wrinkly face brown, inner yellowish-brown is degree, spray clear water, and taking-up, dries;

13, Semen Ginkgo: pick clean impurity, removing duricrust;

14, Folium Perillae: pick clean impurity, dry;

15, Semen Platycladi: pick clean impurity, the shell that removing is residual and seed coat;

16, the Radix Aucklandiae: put by crude drug in whole in clear water and clean, pull out, moistening 12-24 hour makes soft, section, dries;

17, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

18, Stigma Croci: pick decontamination, and remove yellow feeler;

19, Oletum Trogopterori: pick clean impurity, smashes or sieves dedust bits;

20, Radix Polygoni Multiflori: pick decontamination, cleans, saturating with blister to eighty per cant, pulls out, and profit is even to inside and outside humidity, and section or dice, dry;

21, Myrrha: pick decontamination, breaks into fragment;

22, Semen Helianthi: pick decontamination, dries;

23, Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

24, Rhizoma Ligustici: get crude drug, removing impurity, size stepping, wash quickly is clean, runs through, and section, dries;

25, Herba Solani Septemlobi: summer, autumn extract herb, cleans cutting;

26, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;

27, Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;

28, Fructus Jujubae: pick clean impurity, dry;

29, Carapax Trionycis (processed): be soaked in water, removes skin and flesh, cleans, dries;

30, Pedicellus Cucurbitae: adopt aging Fructus Cucurbitae moschatae autumn, cut Pedicellus Melo, dry.

Two, prepare

1, by the Rhizoma Corydalis of described weight, Scorpio, Semen Litchi, Radix Pseudostellariae, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae Viride, Radix Clematidis, Semen Vaccariae, Herba Pteridis Multifidae, Caulis Sargentodoxae, Retinervus Luffae Fructus, Fructus Crataegi, Semen Ginkgo, Folium Perillae, Semen Platycladi, the Radix Aucklandiae, Cortex Moutan, Stigma Croci, Oletum Trogopterori, Radix Polygoni Multiflori, Myrrha, Semen Helianthi, Herba Epimedii, Rhizoma Ligustici, Herba Solani Septemlobi, Radix Ophiopogonis, Rhizoma Zingiberis Recens, Fructus Jujubae, Carapax Trionycis, Pedicellus Cucurbitae medicine decocts with water secondary, add water 8 times amount for the first time, soak after 90 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 35 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.

2, add water the medicinal residues of filtration 6 times amount, first boils with high heat, then use slow fire boiling 40 minutes, filters to obtain second time decoction liquor.

3, by twice decoction liquor mixing and stirring, be divided into 4 doses and take.

Medicine of the present invention has relieving convulsion, dredging collateral, warming middle-JIAO, and cold expelling is regulated the flow of vital energy, and the function of pain relieving, is used for the treatment of dysmenorrhea, short treating period, instant effect, non-relapse after healing, has no side effect.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] Drug therapy dysmenorrhea of the present invention

1, physical data

Accept out-patient's totally 305 examples for medical treatment.

2, diagnostic criteria

Clinical manifestation

Namely primary dysmenorrhea each menstrual onset from menophania feels sagging distention in the smaller abdomen and spasmic pain, and severe patient is with feeling sick and vomiting, and pain district can be radiated to back part and femoribus internus.Pain time continues 48 ~ 72h, need what menorrhagia, after having clot and tissue substance to discharge, pain can be alleviated, the tissue substance pinkiness of general discharge, lamellar, not of uniform size, sometimes this be endometrium is caused by full wafer film falls like leg-of-mutton tube also full wafer, this tissue title uterine decidua cast.This dysmenorrhea is also known as membranous dysmenorrhea.

Primary dysmenorrhea person per anum looks into (unmarried) all without obvious positive sign.If dysmenorrhea medical history for a long time also can find that uterine activity degree is not good enough, bilateral adnexa has enclosed mass to be formed or rear excavated part tuberosity, has tenderness.Endometriosis, chocolate cyst of ovary may be suffered from, often show as secondary dysmenorrhoea.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 7 days, is a course for the treatment of, takes 5 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: transference cure, body constitution recovers normal, observes half a year without recidivist;

Take a turn for the better: symptom is clearly better, and body constitution is progressively recovered;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy dysmenorrhea patient 305 example of the present invention, effective 290 examples of result, obvious effective rate is 95.08%, and take a turn for the better 11 examples, and improvement rate is 3.61%, and invalid 4 examples, total effective rate is 98.69%.

Claims

1. treat a medicine for dysmenorrhea, it is characterized in that: it is made up of the crude drug in following weight range:

Rhizoma Corydalis 5-15 gram of Scorpio 5-15 gram of Semen Litchi 5-15 gram

Radix Aucklandiae 5-15 gram of Cortex Moutan 3-9 gram of Stigma Croci 5-15 gram

Fructus Jujubae 5-15 gram of Carapax Trionycis 5-15 gram of Pedicellus Cucurbitae 3-9 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Rhizoma Corydalis 10 grams of Scorpios 10 grams of Semen Litchis 10 grams

Semen Ginkgo 15 grams of Folium Perillaes 10 grams of Semen Platycladi 10 grams

Fructus Jujubae 10 grams of Carapax Trionycis 10 grams of Pedicellus Cucurbitaes 6 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

(2) Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;

(3) Semen Litchi: get crude drug, removing impurity, the used time smashs to pieces;

(4) Radix Pseudostellariae: extract fibrous root, dry;

(5) Fructus Alpiniae Oxyphyllae: get Fructus Alpiniae Oxyphyllae and put in pot, fry to shell burned black, take out cold, removing shell, gets core and smashs use to pieces;

(6) Pericarpium Citri Reticulatae Viride: pick clean impurity, be soaked in water, pull out, run through, section, dries;

(7) Radix Clematidis: pick clean impurity, removes residual stem, is soaked in water, pull out and run through, cutting, dry;

(8) Semen Vaccariae: clean impurity of winnowing with a dustpan, puts in pot, takes out, cool when frying to spend six, seventy percent to popping in vain with slow fire;

(9) Herba Pteridis Multifidae: the whole year can adopt, picks clean impurity, cutting, dries;

(10) Caulis Sargentodoxae: be soaked in water, cleans spare, runs through, and section, dries;

(11) Retinervus Luffae Fructus: clean and dry, cutting;

(12) Fructus Crataegi: get and pick clean Fructus Crataegi, put in pot scorching stir-fry of useing force to outer wrinkly face brown, inner yellowish-brown is degree, spray clear water, and taking-up, dries;

(13) Semen Ginkgo: pick clean impurity, removing duricrust;

(14) Folium Perillae: pick clean impurity, dry;

(15) Semen Platycladi: pick clean impurity, the shell that removing is residual and seed coat;

(16) Radix Aucklandiae: put by crude drug in whole in clear water and clean, pull out, moistening 12-24 hour makes soft, section, dries;

(17) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

(18) Stigma Croci: pick decontamination, and remove yellow feeler;

(19) Oletum Trogopterori: pick clean impurity, smashes or sieves dedust bits;

(20) Radix Polygoni Multiflori: pick decontamination, cleans, saturating with blister to eighty per cant, pulls out, and profit is even to inside and outside humidity, and section or dice, dry;

(21) Myrrha: pick decontamination, breaks into fragment;

(22) Semen Helianthi: pick decontamination, dries;

(23) Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

(24) Rhizoma Ligustici: get crude drug, removing impurity, size stepping, wash quickly is clean, runs through, and section, dries;

(25) Herba Solani Septemlobi: summer, autumn extract herb, cleans cutting;

(26) Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;

(27) Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;

(28) Fructus Jujubae: pick clean impurity, dry;

(29) Carapax Trionycis (processed): be soaked in water, removes skin and flesh, cleans, dries;

(30) Pedicellus Cucurbitae: adopt aging Fructus Cucurbitae moschatae autumn, cut Pedicellus Melo, dry;

(2) prepare

(1) by the Rhizoma Corydalis of described weight, Scorpio, Semen Litchi, Radix Pseudostellariae, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae Viride, Radix Clematidis, Semen Vaccariae, Herba Pteridis Multifidae, Caulis Sargentodoxae, Retinervus Luffae Fructus, Fructus Crataegi, Semen Ginkgo, Folium Perillae, Semen Platycladi, the Radix Aucklandiae, Cortex Moutan, Stigma Croci, Oletum Trogopterori, Radix Polygoni Multiflori, Myrrha, Semen Helianthi, Herba Epimedii, Rhizoma Ligustici, Herba Solani Septemlobi, Radix Ophiopogonis, Rhizoma Zingiberis Recens, Fructus Jujubae, Carapax Trionycis, Pedicellus Cucurbitae medicine decocts with water secondary, add water 8 times amount for the first time, soak after 90 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 35 minutes, filter first time decoction liquor, first time decoction liquor is poured in container,

(2) add water the medicinal residues of filtration 6 times amount, first boils with high heat, then use slow fire boiling 40 minutes, filters to obtain second time decoction liquor;

(3) by twice decoction liquor mixing and stirring, be divided into 4 doses and take.