CN105687338A

CN105687338A - Drug for treating simple goiter

Info

Publication number: CN105687338A
Application number: CN201610139967.7A
Authority: CN
Inventors: 庄甲菁
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-03-11
Filing date: 2016-03-11
Publication date: 2016-06-22

Abstract

The invention relates to a drug for treating simple goiter. The drug is prepared from raw materials in parts by weight as follows: 6 parts of Cinnamomum subavenium, 13 parts of stems and leaves of Yunnan Sabia, 15 parts of all-grass of Chinese Ixeris, 13 parts of roots of Oblique Rhychoglossum, 9 parts of kadsura pepper stems, 12 parts of milky-white anaphalis, 9 parts of pumice and 1 part of oleander. The bark of Cinnamomum subavenium has effects of warming the spleen and the stomach, dispelling cold, regulating qi, alleviating pain, activating blood circulation and freeing vessels; the stems and leaves of Yunnan Sabia have effects of dispelling wind, easing pain, eliminating dampness and removing toxins; the all-grass of Chinese Ixeris has the effects of clearing heat, removing toxins, diminishing swelling, expelling pus, cooling blood and stopping bleeding; the roots of Oblique Rhychoglossum have effects of softening hardness and dissipating stagnation; the kadsura pepper stems have effects of expelling wind-dampness, freeing channels, regulating qi and alleviating pain; the milky-white anaphalis have effects of clearing heat, relieving coughs, dissipating blood stasis and stopping bleeding; the pumice has effects of clearing the lung, eliminating phlegm, softening hardness and dissipating stagnation; the oleander has effects of strengthening the heart, promoting diuresis, eliminating phlegm, relieving asthma, easing pain and removing blood stasis. The medicines are combined for use and have effects of soothing the liver, regulating qi, softening hardness, dissipating stagnation, relieving sore throats, restoring voice, tonifying the spleen and checking diarrhea. Clinical tests prove that the drug can treat the simple goiter safely and effectively.

Description

A kind of medicine for treating simple goiter

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine for treating simple goiter。

Background technology

Simple goiter is the goiter of euthyroidism, is with the compensatory thyromegaly caused by the reasons such as iodine deficiency, goitrogen or relevant enzyme defect, without obvious hyperthyroidism or go down, therefore also known as nontoxic goiter。Simple goiter, is characterized in distributing in non-Goiter Endemic district, and without tumor and inflammation, course of disease initial stage thyroid mostly is anthorisma, can develop into the enlargement of many nodositas later。Primary disease is more common in women, point endemic goiter and sporadic goiter two types。The former be mainly seen in live in off sea farther out, the crowd in mountain area that height above sea level is higher, have substantial connection with region iodine deficiency, often affect crowd's intelligent development；The latter be mainly seen in adolescence, trimester of pregnancy, cold, infection and direct stimulation etc. stress situation, the physiological need amount increase with thyroxin is relevant, most prognosis bona。Especially adolescent goiter, disappears comparatively fast through suitably adjusting。

Simple goiter belongs to the traditional Chinese medical science " gas is thin " category。If thyromegaly is more very, compressing Cervical Vessels and cause shallow jugular vein and telangiectasis and fill, then be equivalent to " muscle wart " and " hemangioma of the neck " category。

The cause of disease

Most of simple goiter patients do not have the obvious cause of disease, and the morbidity of some patients is likely to relevant with following factors:

1. iodine deficiency

Iodine is the necessary element of synthetic thyroid hormone, and I is not enough, and body can not synthesize enough thyroxins, and feedback Stimulation of Pituitary Gland TSH raises, and the TSH of rising promotes thyroid hyperplasia, causes goiter。China is the country that iodine deficiency is serious, country-driven " whole people's iodized salt " policy is to prevent the maximally effective measure of iodine deficiency。

2. enzyme defect

In thyroxin building-up process, the birth defect of some enzyme or acquired defect can cause simple goiter, as iodide transport enzyme defect, peroxide enzyme defect, go chlB4 defect, iodotyrosine to couple enzyme defect etc.。

3. medicine

The medicines such as iodide, fluoride, lithium salts, aminophenazone, aminoglutethimide, sulfonamides, Phenylbutazone, amiodarone, invenol, thiamazole, propylthiouracil can cause simple goiter。These medicines, by different mechanism, interference or the links in suppression thyroxin building-up process, finally affect thyroxin synthesis, and feedback causes TSH to raise, and causes goiter。

4. smoking

Smoking can cause simple goiter, because thiocyanate in inhalation (inhalatio), this is a kind of goitrogen, and smoker's Serum Thyroglobulin is higher than non smoker。

5. inherited genetic factors

The 5000 many cases monozygotic twins in non-Goiter Endemic area and the same sex twin children of binovular twin were once studied by Brix (1999), find that the genetic predisposition of simple goiter accounts for 82%, 18% owing to environmental factors, and this result of study is the important evidence that sporadic goiter can be caused by inherited genetic factors。Have now been found that the inherited genetic factors relevant with sporadic goiter morbidity has 14q, multinodular goiter gene-1,3q26, Xp22, Thyroglobulin etc.。Epidemiologic data shows, goiter usually has familial aggregation。

6. other diseases

Simple goiter can be there is in hypercortisolism, acromegaly and end stage renal disease。

Clinical manifestation

1. thyromegaly or neck region lump

Thyromegaly is the distinctive clinical manifestation of nontoxic goiter, and patient normal main suit cervical region is thicker or collar is felt nervous。Thyroid is positioned at throat portion, once enlargement is easily found by sufferers themselves or household, goiter can down along extending into thoracic cavity sometimes, and this is likely due in thorax negative pressure and caused by tumor weight tenesmus；Accidental goiter betides aberrant thyroid tissue。

Course of disease early stage is diffusivity thyromegaly, have a medical check-up visible enlargement thyroid smooth surface, matter is soft, up and down with swallowing, atremia and vascular murmur, along with the development of the course of disease, engender thyroid nodule enlargement, be generally unsymmetry, the multiple tuberosity of many nodositas can flock together, and shows as neck region lump。Tuberosity differs in size, quality not etc., position differs。Goiter is general without pain, as nodosity internal hemorrhage then may occur in which pain。As health check-up finds that the hard mobility of thyroid nodule matter is not good enough, the possibility that cancerates should be watched out for。

2. pressure symptom

Pressure symptom is the most important clinical manifestation of nontoxic goiter, and pressure symptom occurs the course of disease late period, but namely retrosternal goiter early stage may occur in which pressure symptom。

Tracheas suppressed: slight tracheal compression is generally asymptomatic, pressurized is heavier cause stridulate, dyspnea, cough。What retrosternal goiter caused stridulate and dyspnea is everlasting, and night occurs, and (as lifted on patient's upper limb) can occur with Body Position Change。

Compressing esophagus: esophagus position more rearward, generally not easily pressurized, grow backward such as goiter and hold esophagus, can oppress esophagus cause swallow not smooth or difficult。

Compressing recurrent laryngeal nerve: simple goiter seldom oppresses recurrent laryngeal nerve, unless merged thyroid malignancy, tumor-infiltrated unilateral recurrent laryngeal nerve can cause vocal cord paralysis, hoarseness, bilateral recurrent laryngeal nerve to get involved also can cause dyspnea。When recurrent laryngeal nerve pressurized symptom occurs, highly vigilant of to cancerate possibility。

Vascular compression: huge goiter, especially retrosternal goiter can oppress jugular vein, subclavian vein even superior vena cava, cause facial edema, cervical region and the expansion of upper breast superficial vein

Compressing phrenic nerves: retrosternal goiter can oppress phrenic nerves, causes singultus, the swollen liter of diaphragm。Phrenic nerves pressurized is more rare。

Compressing cervical sympathetic nerve chain: retrosternal goiter can oppress cervical sympathetic nerve chain, causes Horners syndrome。

Drug therapy

1. TSH suppression therapy

The pathogenesis of part simple goiter is relevant with the stimulation of TSH, can suppress the secretion of endogenous TSH with exogenous thyroxin, thus preventing and treating growth strumous, TSH suppression therapy has been widely used in the treatment of simple goiter。

Before TSH suppression therapy, serum TSH level should be detected, if serum TSH level is normal, then can carry out TSH suppression therapy, if < 0.1mU/L, then prompting has subclinical hyperthyroidism to serum TSH, should row TSH suppression therapy。Serum TSH level should be detected during TSH suppression therapy or Thyroid Intaking I leads (RAIU), it is considered that < 0.1mU/L or RAIU < 5%, for suppress completely, is that part suppresses higher than this level to serum TSH。It is generally believed that serum TSH level is suppressed to the threshold level of normal range。Effectiveness for TSH Suppressive therapy is a controversial problem, needs to be suppressed to TSH below normal value, and note the long-term side effect suppressing TSH treatment to be likely to result in heart and skeleton during treatment。

2. radioactivity iodine 131 treatment

Radioactivity iodine 131 has been widely used in the treatment of toxic goiter, not yet extensive use in the treatment of nontoxic goiter。Situation changes in recent years, and iodine 131 treatment simple goiter is more and more paid attention to。Over nearly 10 years, there are many sections of reported literatures to adopt disposable heavy dose of I to treat simple goiter and achieve good curative effect, the thyroid volume of the patient of 80%～100% can be made to reduce 40%～60%。

3. treatment by Chinese herbs

Chinese traditional treatment is started with marrow, whole body therapeutic, makes disease start to take a turn for the better, and human body recovers normal physiological function。

Medical material involved in the present invention is all recorded in " China's book on Chinese herbal medicine " as seen。

Summary of the invention

It is desirable to provide a kind of medicine for treating simple goiter, by selecting suitable medical material and proportioning thereof, reach safely and effectively to cure the purpose of simple goiter。

In order to achieve the above object, the present invention is by the following technical solutions:

A kind of medicine for treating simple goiter, it is characterized in that, it is to be prepared from by the raw medicinal material of following weight proportion: fragrant 6 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis et Folium Sabiae yunnanensis 13 parts, Herba Ixeritis chinensis 15 parts, Radix Rhynchoglossi Obliqui 13 parts, Caulis Piperis Kadsurae 9 parts, Herba Anaphalidis Lacteae 12 parts, Pumex 9 parts, Folium seu Cortex Nerii 1 part。

Illustrate the method have the benefit that below in conjunction with theories of Chinese materia medica

It has been recognised by the inventors that the thyroid cause of disease of pure to be mainly feelings will internal injury, diet and water and soil inappropriate etc., and make dry phlegm-syndrome stasis of blood three stop up knot throat and send out as goiter。Pathological change is long-term troubled thoughts anxiety or strongly fragrant angry angry, often makes the liver failing to maintain the normal flow of QI, depression and stagnation of QI, and body fluid is cloth not, is condensed into expectorant, mental disorder pent-up, stops up knot throat, then becomes goiter。Diet and water and soil are inappropriate, affect spleen and stomach function, and board loses strong fortune, it is impossible to transmitting and distributing the fluids, the poly-expectorant that forms, mental disorder knot, with the passing of time become the stasis of blood to make goiter enlargement or nodosity, therefore gas, expectorant, stasis of blood three stop up the main pathogenesis that knot throat is thyromegaly。Therefore resolving depression of regulating the flow of vital energy then is taked in treatment, reduce phlegm dispersing tumor, movable blood soft hard。

The present invention uses: fragrant Cortex cinnamomi japonici (Ramulus Cinnamomi) warming spleen and stomach for dispelling cold, regulating QI to relieve pain, blood circulation and channel invigorating；Caulis et Folium Sabiae yunnanensis dispels the wind analgesia, removing dampness and detoxicating；Herba Ixeritis chinensis heat-clearing and toxic substances removing, detumescence and apocenosis, cooling blood for hemostasis；Radix Rhynchoglossi Obliqui hard masses softening and resolving；Caulis Piperis Kadsurae wind-damp dispelling, the meridian dredging, regulating QI to relieve pain；Herba Anaphalidis Lacteae clearing and antitussive, dissipating blood stasis stops blooding；Pumex removing heat from the lung and dissipating phlegm, hard masses softening and resolving；Folium seu Cortex Nerii heart tonifying diuresis, eliminating phlegm relieving asthma, ease pain blood stasis dispelling。All medicines share, and reach effect of depressed liver-energy dispersing and QI regulating, hard masses softening and resolving, relieving sore throat to recover voice, invigorating the spleen to arrest diarrhea。

Below in conjunction with clinical laboratory data, beneficial effects of the present invention is described:

1, physical data

Inventor collects 65 example simple goiter patients altogether between in July ,-2015 in January, 2013。It is randomly divided into: treatment group 33 example, matched group 32 example。Male 6 examples of wherein treatment group, female 27 example, 25～67 years old age, the course of disease 3 months～4 years；Matched group man 7 examples, female 25 example, between 23～64 years old age, the course of disease 5 months～4 years。The data such as two groups of sexes, age, courses of disease there was no significant difference, and has comparability。

Diagnostic criteria

1. cervical region both sides or side are anthorisma, diffusivity goiter, cervical region Zygomorphy anthorisma；Simple node goiter poke side is notable, it is possible to one or more tuberositys differed in size, and tuberosity cyst sample becomes, and if hair follicle internal hemorrhage, tuberosity can increase in a short time。

2. thyroid body performance is flatter, matter is soft, and body of gland can move up and down with swallowing；Color of the leather is as usual。

3. as swelling is excessive, can tracheas suppressed, esophagus, blood vessel, nerve and cause following symptoms。

Tracheas suppressed: relatively common, owing to tracheal compression is compeled, trachea inner chamber narrows, then dyspnea occur, and tracheal wall is pressurized over a long time, it is possible to softening, causes and suffocates。

Compressing esophagus: relatively rare。Only retrosternal goiter is likely to compressing esophagus, causes dysphagia or swallows sense of discomfort。But obstruction will not be caused。

, there is the obvious expansion of cervical region and front superficial vein simultaneously in the big vein in compressing throat depth portion: due to incidence blood backflow difficulty, patient facial region is livid purple color edema。

Compressing recurrent laryngeal nerve: vocal cord paralysis (mostly being side), patient's hoarseness can be caused。

Compressing cervical sympathetic nerve pitch chain: bernard's syndrome can be caused。This kind of situation is extremely rare。

Inclusive criteria

1. diagnostic criteria is met；2. age 18～70 years old；3. compliance is good；4. Informed Consent Form is signed voluntarily。

Exclusion standard

1. pregnant, women breast-feeding their children；2. suffer from severe cardiac, lung, liver, renal disease patient；3. spiritedness systemic disease, it is impossible to partner treatment person；4. through the patient of other drug treatment after morbidity。

2, Therapeutic Method

The capsule that the oral present invention specific embodiment 3 for the treatment of group prepares, every day 3 times。Treat 1 month。

Matched group oral thyroid sheet, each 30mg, every day 3 times。Treat 1 month。

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterions of therapeutical effect

1. recovery from illness: thyromegaly disappears, and various functions inspection is in normal range；

2. effective: thyromegaly is obviously reduced, observe without substantially development through long-term；

3. invalid: symptom and Index for examination are without improvement。

3.2 treatment statistical results are in Table 1。

1 liang of table group comparitive study

Visible, simple goiter can safely and effectively be treated by the medicine that the present invention prepares, and cure rate is high。

Detailed description of the invention

In order to be more fully understood that and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment。

Embodiment 1

Weigh: fragrant 6 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis et Folium Sabiae yunnanensis 13 grams, Herba Ixeritis chinensis 15 grams, Radix Rhynchoglossi Obliqui 13 grams, Caulis Piperis Kadsurae 9 grams, Herba Anaphalidis Lacteae 12 grams, Pumex 9 grams, Folium seu Cortex Nerii 1 gram；Add 8 times amount water, decoct 1.5 hours, filter；Filtering residue adds 6 times amount water, decocts 1 hour, filters；Merging filtrate, is concentrated into 120 grams, must meet the decoct of one day consumption of adult normal。

For treating simple goiter。Oral, daily once。

Embodiment 2

Weigh: fragrant 6 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis et Folium Sabiae yunnanensis 13 grams, Herba Ixeritis chinensis 15 grams, Radix Rhynchoglossi Obliqui 13 grams, Caulis Piperis Kadsurae 9 grams, Herba Anaphalidis Lacteae 12 grams, Pumex 9 grams, Folium seu Cortex Nerii 1 gram；Add 10 times amount water, decoct 2 hours, filter；Filtering residue adds 8 times amount water, decocts 1.5 hours, filters；Merging filtrate, concentration, dry, packaging, the powder of one day consumption of adult normal must be met。

For treating simple goiter。Oral, every bu is taken for twice sooner or later。

Embodiment 3

Weigh: fragrant 6 grams of Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis et Folium Sabiae yunnanensis 13 grams, Herba Ixeritis chinensis 15 grams, Radix Rhynchoglossi Obliqui 13 grams, Caulis Piperis Kadsurae 9 grams, Herba Anaphalidis Lacteae 12 grams, Pumex 9 grams, Folium seu Cortex Nerii 1 gram；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentration, dry, load capsule shells, the capsule of one day consumption of adult normal must be met。

For treating simple goiter。Oral, every bu morning, noon and afternoon take for three times。

Claims

1. the medicine being used for treating simple goiter, it is characterized in that, it is to be prepared from by the raw medicinal material of following weight proportion: fragrant 6 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis et Folium Sabiae yunnanensis 13 parts, Herba Ixeritis chinensis 15 parts, Radix Rhynchoglossi Obliqui 13 parts, Caulis Piperis Kadsurae 9 parts, Herba Anaphalidis Lacteae 12 parts, Pumex 9 parts, Folium seu Cortex Nerii 1 part。

2. a kind of medicine for treating simple goiter as claimed in claim 1, it is characterized in that, its preparation method is: weigh: fragrant 6 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis et Folium Sabiae yunnanensis 13 parts, Herba Ixeritis chinensis 15 parts, Radix Rhynchoglossi Obliqui 13 parts, Caulis Piperis Kadsurae 9 parts, Herba Anaphalidis Lacteae 12 parts, Pumex 9 parts, Folium seu Cortex Nerii 1 part；Add 8 times amount water, decoct 1.5 hours, filter；Filtering residue adds 6 times amount water, decocts 1 hour, filters；Merging filtrate, is concentrated into 120 parts, obtains decoct；Above-mentioned part each means weight portion。

3. a kind of medicine for treating simple goiter as claimed in claim 1, it is characterized in that, its preparation method is: weigh: fragrant 6 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis et Folium Sabiae yunnanensis 13 parts, Herba Ixeritis chinensis 15 parts, Radix Rhynchoglossi Obliqui 13 parts, Caulis Piperis Kadsurae 9 parts, Herba Anaphalidis Lacteae 12 parts, Pumex 9 parts, Folium seu Cortex Nerii 1 part；Add 10 times amount water, decoct 2 hours, filter；Filtering residue adds 8 times amount water, decocts 1.5 hours, filters；Merging filtrate, concentration, dry, packaging, obtain powder；Above-mentioned part each means weight portion。

4. a kind of medicine for treating simple goiter as claimed in claim 1, it is characterized in that, its preparation method is: weigh: fragrant 6 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis et Folium Sabiae yunnanensis 13 parts, Herba Ixeritis chinensis 15 parts, Radix Rhynchoglossi Obliqui 13 parts, Caulis Piperis Kadsurae 9 parts, Herba Anaphalidis Lacteae 12 parts, Pumex 9 parts, Folium seu Cortex Nerii 1 part；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentration, dry, load capsule shells, obtain capsule；Above-mentioned part each means weight portion。