CN111773336A - Traditional Chinese medicine composition for treating common neocoronary pneumonia and preparation and application thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition of ephedra, apricot and stephania sinica for treating common type new coronary pneumonia, and a preparation method and an application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 5-20 parts of mix-fried herba ephedrae, 10-30 parts of almond, 10-30 parts of gypsum, 10-30 parts of rhizoma anemarrhenae, 10-30 parts of rhizoma smilacis glabrae, 10-30 parts of fresh rhizoma phragmitis, 10-30 parts of raw semen coicis, 10-30 parts of semen benincasae, 10-30 parts of peach kernel, 10-30 parts of wild buckwheat root, 10-30 parts of fried radix scutellariae, 10-30 parts of platycodon grandiflorum, 10-30 parts of ginger processed pinellia tuber, 10-30 parts of caulis perillae and 10-30 parts of sappan wood. The traditional Chinese medicine composition obviously improves respiratory symptoms and shortens the isolation time, and the traditional Chinese medicine composition is a medicine prescription selected by taking heat clearing and phlegm reducing as a treatment principle under the guidance of the theory of traditional Chinese medicine, has no obvious toxic or side effect in treatment, can be taken for a long time, and has wide application range.

Description

Traditional Chinese medicine composition for treating common neocoronary pneumonia and preparation and application thereof

(I) technical field

The invention relates to a ephedra, apricot and stephania sinica diels traditional Chinese medicine composition for treating common type new coronary pneumonia and preparation and application thereof.

(II) background of the invention

Since 12 months in 2019, only six kinds of coronavirus which can infect human are known, wherein only two kinds of SARS-CoV and MERS-CoV can kill pneumonia together, and the other four kinds of HcoV-229E, HcoV-NL63, HcoV-HKU1 and HcoV-OC43 coronavirus can only cause mild respiratory tract infection. This new coronavirus pneumonia seems to cause symptoms similar to SARS, and a recent clinical study from china released by Lancet showed that 41 patients with 2019-nCoV infection who had been diagnosed in the laboratory, 1/3 needed intensive care, 6 deaths, and 5 patients with acute cardiac injury, and the latter study of concurrent epidemics reported clinical and microbiological data from six families, confirming the possibility of interpersonal spread. The situation of epidemic is severe, the propagation path is unknown at present, and no specific therapeutic drug is available, so that in view of the actual combat experience during the SARS epidemic period in 2003, the unique advantages of the traditional Chinese medicine in the epidemic prevention and treatment process need to be brought into play at present.

Respiratory tract infection caused by the respiratory tract virus has the characteristics of seasonality, epidemic, infectivity and the like, and the respiratory tract infection belongs to the category of warm diseases in traditional Chinese medicine, and can be called as exhaling according to different seasons such as wet temperature, spring temperature, wind temperature, winter temperature and the like. In thousands of years of clinical practice, ancient physicians accumulated valuable experience in the treatment of seasonal disorders. As early as in Su Wen & Ci Fang Lun, we propose to avoid its toxic pathogen. Emphasizes the idea that the pestilence needs to be prevented before the disease is caused, and inspires the epidemic prevention nowadays. The "Shanghai treatise on the clinical experience of ancient physicians in treating the acute infectious disease" Shanghai "represented by Zhang Zhongjing was recorded in the Shanghai treatise on the typhoid. The prescriptions of ephedra decoction, small bupleurum decoction, large chengqi decoction, white tiger decoction, Sini decoction and the like are always the main prescriptions for treating seasonal infectious diseases by the later-aged doctors. In the period of Song Jinyuan and in the beginning of Ming dynasty, the pestilence in China is rampant, doctors and families use the classics in the Shang Han Lun, and the doctors and the families have innovation in combination with clinical practice, thereby creating the epidemic febrile disease and making a lot of contribution which cannot be killed.

The pathogenesis of the disease is that pathogenic factors of pestilence enter from mouth to nose, firstly invade the lung, the lung qi is damaged, and the lung qi fails to clear and descend, so that cough, dispersion and descent disorder, dyspnea and tachypnea, chest distress and dyspnea occur. The middle stage of the disease is usually syndrome of accumulated dampness-heat.

Disclosure of the invention

The invention aims to provide a traditional Chinese medicine composition for treating common type neocoronary pneumonia and application thereof, under the guidance of traditional Chinese medicine theory, aiming at the pathogenesis characteristics of the common type neocoronary pneumonia, the traditional Chinese medicine composition capable of clearly improving the disease is obtained by screening traditional Chinese medicine raw materials through reasonable proportioning and synergistic effect of all medicinal materials, and the prepared traditional Chinese medicine composition can achieve the purposes of treating patients with the new type coronary pneumonia and reducing severe symptoms of the patients with mild symptoms, has no toxic or side effect, is suitable for being taken by people, and has a clear effect on treating the common type neocoronary pneumonia.

The technical scheme adopted by the invention is as follows:

the invention provides a traditional Chinese medicine composition for treating common neocoronary pneumonia, which is prepared from the following raw materials in parts by mass: 5-20 parts of mix-fried ephedra herb, 10-30 parts of almond, 10-30 parts of gypsum, 10-30 parts of rhizoma anemarrhenae, 10-30 parts of rhizoma smilacis glabrae, 10-30 parts of fresh rhizoma phragmitis, 10-30 parts of raw semen coicis, 10-30 parts of white gourd seed, 10-30 parts of peach kernel, 10-30 parts of wild buckwheat root, 10-30 parts of fried radix scutellariae, 5-30 parts of platycodon grandiflorum, 5-30 parts of rhizoma zingiberis semipinellia, 10-30 parts of caulis perillae and 10-30 parts of sappan wood.

Further, preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 9 parts of mix-fried ephedra herb, 10 parts of almond, 30 parts of gypsum, 12 parts of rhizoma anemarrhenae, 10 parts of glabrous greenbrier rhizome, 30 parts of fresh reed rhizome, 30 parts of raw coix seed, 30 parts of white gourd seed, 12 parts of peach kernel, 30 parts of wild buckwheat root, 12 parts of fried baical skullcap root, 9 parts of platycodon root, 9 parts of ginger processed pinellia tuber, 12 parts of caulis perllae and 12 parts of sappan wood.

Further, the traditional Chinese medicine composition also comprises a pharmaceutically acceptable carrier, and is prepared into granules, decoction or oral liquid which are well known in the art.

The common traditional Chinese medicine composition for treating the Xinguan pneumonia is prepared by selecting roasted ephedra, almond, gypsum (decocted first), rhizoma anemarrhenae, rhizoma smilacis glabrae, rhizoma phragmitis (particularly preferred fresh rhizoma phragmitis), raw coix seed, wax gourd seed, peach kernel, wild buckwheat root, fried scutellaria baicalensis, platycodon grandiflorum, ginger processed pinellia ternate, caulis perllae and sappan wood to prepare active components; has the effects of pungent and cool nature, dispersing and purging, clearing lung-heat and relieving asthma, clearing lung-heat and eliminating phlegm, removing blood stasis and expelling pus.

The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: weighing mix-fried ephedra herb, almond, gypsum, rhizoma anemarrhenae, glabrous greenbrier rhizome, fresh reed rhizome, raw coix seed, white gourd seed, peach seed, wild buckwheat root, fried baical skullcap root, platycodon root, ginger processed pinellia tuber, perilla stem and sappan wood according to the formula amount, mixing, adding water which is 5 times of the total weight of the medicinal materials, soaking for 1 hour, heating and decocting for 20 minutes, boiling and filtering; and adding 3 times of water into the medicine residues, heating to boil, filtering after boiling, combining the filtrates, and concentrating until the density is 1.02-1.2 to obtain decoction.

The invention also relates to application of the traditional Chinese medicine composition in preparing a medicine for treating common neocoronary pneumonia.

The general type new coronary pneumonia of the invention: meets the diagnosis standard, has fever and respiratory tract symptoms, and has the manifestation of pneumonia in imaging.

Common type Xinguan pneumonia is characterized by internal heat transpiration and heat-induced fluid damage. Gypsum Fibrosum is used in the prescription for treating diseases due to its reasonable constitution. Gypsum, gypsum, pungent in flavor and cold in property, enters the lung and stomach meridians, pungent in property and capable of ventilating, cold in property and clearing heat, can clear heat from the muscles and muscles, and can remove qi and remove high fever. Matching with heat-clearing and detoxifying drugs, and selecting the scutellaria baicalensis and the tartarian buckwheat root which enter the lung meridian at the same time to clear and purge lung heat. Herba Ephedrae and semen Armeniacae amarum may be added for the purpose of preventing heat and clearing lung qi. The Qianjin Phragmites communis stem decoction is a moistening and descending product, with Phragmites communis root passing through and clearing the upper heat, sweet and cold in nature, clearing lung-heat and stomach-heat, and promoting the production of body fluid, and wax gourd seed is sweet and cold in nature, clearing heat and resolving phlegm, especially good at promoting diuresis and expelling pus; semen coicis is sweet, bland and slightly cold, can clear heat, discharge pus, invigorate spleen, promote diuresis, excrete dampness, and help to remove phlegm-dampness in lung; peach kernel, semen Persicae is pungent and bitter in flavor and neutral in nature, has the actions of activating blood and resolving phlegm, relieving cough and asthma, and its action of removing blood stasis and resolving phlegm is true without being lost.

Compared with the prior art, the invention has the following beneficial effects: the traditional Chinese medicine composition obviously improves respiratory symptoms and shortens the isolation time, and the traditional Chinese medicine composition is a medicine formula selected based on the principle of clearing heat and reducing phlegm under the guidance of the theory of traditional Chinese medicine, has no obvious toxic or side effect in treatment, can be taken for a long time, and has wide application range.

(IV) detailed description of the preferred embodiments

The invention will be further described with reference to specific examples, but the scope of the invention is not limited thereto:

the raw materials used in the embodiment of the invention are all collected and prepared according to the 'Chinese pharmacopoeia' 2015 edition.

EXAMPLE 1 Chinese medicinal composition

1. The formula is as follows: the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 9 parts of mix-fried ephedra herb, 10 parts of almond, 30 parts of gypsum, 12 parts of rhizoma anemarrhenae, 10 parts of glabrous greenbrier rhizome, 30 parts of fresh reed rhizome, 30 parts of raw coix seed, 30 parts of white gourd seed, 12 parts of peach kernel, 30 parts of wild buckwheat root, 12 parts of fried baical skullcap root, 9 parts of platycodon root, 9 parts of ginger processed pinellia tuber, 12 parts of caulis perllae and 12 parts of sappan wood.

2. Preparation:

weighing 9g of mix-fried ephedra herb, 10g of almond, 30g of gypsum, 12g of rhizoma anemarrhenae, 10g of glabrous greenbrier rhizome, 30g of fresh reed rhizome, 30g of raw coix seed, 30g of white gourd seed, 12g of peach seed, 30g of wild buckwheat root, 12g of fried baical skullcap root, 9g of platycodon root, 9g of ginger processed pinellia tuber, 12g of perilla stem and 12g of sappan wood according to the formula amount, adding 5 times of water by the total weight of the medicinal materials, soaking for 1 hour, heating and decocting for 20 minutes, boiling and filtering; and adding 3 times of water into the medicine residues, heating the medicine residues to boil, filtering the medicine residues after boiling, combining the filtrate, and concentrating the filtrate until the density is 1.02-1.2 to obtain decoction.

Example 2 general clinical observations of the Chinese medicinal composition of the invention for treating New coronary pneumonia

63 patients were from Wenzhou Central Hospital, Taizhou Enze Hospital, and Wenling first-person Hospital, 15, 46, and 2 patients, respectively. The research adopts a queue research method, mainly observes the case evaluation curative effect summary, and observes the condition of the patient. Dividing into a control group and an observation group according to whether the patients take the traditional Chinese medicine orally or not, naturally grouping according to the clinical treatment condition, and not limiting the number of each group.

Inclusion criteria were: firstly, a patient with the novel coronavirus pneumonia is diagnosed; ② the clinical typing belongs to the novel common type of coronavirus pneumonia; age 18-85 years old; fourthly, the informed consent is signed.

Exclusion criteria: firstly, patients with relatively serious primary diseases such as heart, lung, liver, kidney, brain, hematopoietic system and the like are combined; ② pregnant or lactating women; ③ psychiatric patients; and fourthly, the Chinese herbal medicines are participating in other clinical testers or taking other Chinese herbal medicines.

The method comprises the following steps: whether to apply the traditional Chinese medicine treatment is determined according to the will of a patient, and the traditional Chinese medicine treatment is divided into a control group and an observation group according to the application condition of the traditional Chinese medicine.

Control group: conventional western medicine treatment (refer to the fifth edition of trial run of 'diagnosis and treatment plan for pneumonia infected by novel coronavirus' issued by national Weijian Commission and national Central office).

Observation group: the decoction prepared by the method of the invention example 1 is added on the basis of western medicine treatment according to the fifth edition of diagnosis and treatment plan for pneumonia infected by novel coronavirus for patients with definite diagnosis of common type novel coronavirus pneumonia, twice a day with 100ml each time, and the treatment course is 14 days.

Observation contents and evaluation index

The observation includes the following aspects:

(1) changes of disease (body temperature, clinical manifestations, outcome, degree of disease and prognosis)

(2) Laboratory examinations (blood routine + CRP, procalcitonin, Lung CT, etc.)

Evaluation indexes are as follows:

(1) the main indexes are as follows: the disease condition is classified into

(2) Secondary indexes are as follows: pathogenic negative conversion rate and duration, and complication rate

And (3) performing data statistical analysis after the treatment course is finished:

each index and data are standardized and processed using SPSS software. All statistical tests used a two-sided test, with differences of less than or equal to 0.05 being statistically significant. The results are shown in tables 1 to 3, and the safety evaluation is shown in table 4, and only 3 of 63 patients showed abnormal liver function, intestinal dysbacteriosis, and hypokalemia, respectively. However, the above complications are closely related to the disease itself, and are not completely drug-related.

TABLE 1 improvement of major clinical symptoms

TABLE 2 Return to Condition

TABLE 3 duration of negative conversion of pathogenic nucleic acids

Claims (5)

1. A traditional Chinese medicine composition for treating common neocoronary pneumonia is characterized by being prepared from the following raw materials in parts by mass: 5-20 parts of mix-fried ephedra herb, 10-30 parts of almond, 10-30 parts of gypsum, 10-30 parts of rhizoma anemarrhenae, 10-30 parts of rhizoma smilacis glabrae, 10-30 parts of fresh rhizoma phragmitis, 10-30 parts of raw semen coicis, 10-30 parts of white gourd seed, 10-30 parts of peach kernel, 10-30 parts of wild buckwheat root, 10-30 parts of fried radix scutellariae, 5-30 parts of platycodon grandiflorum, 5-30 parts of ginger processed pinellia tuber, 10-30 parts of caulis perllae and 10-30 parts of sappan wood.

2. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 9 parts of mix-fried ephedra herb, 10 parts of almond, 30 parts of gypsum, 12 parts of rhizoma anemarrhenae, 10 parts of glabrous greenbrier rhizome, 30 parts of fresh reed rhizome, 30 parts of raw coix seed, 30 parts of white gourd seed, 12 parts of peach kernel, 30 parts of wild buckwheat root, 12 parts of fried baical skullcap root, 9 parts of platycodon root, 9 parts of ginger processed pinellia tuber, 12 parts of caulis perllae and 12 parts of sappan wood.

3. The Chinese medicinal composition of claim 1, wherein the Chinese medicinal composition further comprises a pharmaceutically acceptable carrier, and is prepared into granules, decoction or oral liquid.

4. A method for preparing the traditional Chinese medicine composition of claim 1, which is characterized by comprising the following steps: weighing mix-fried ephedra herb, almond, gypsum, rhizoma anemarrhenae, glabrous greenbrier rhizome, fresh reed rhizome, raw coix seed, white gourd seed, peach seed, wild buckwheat root, fried baical skullcap root, platycodon root, ginger processed pinellia tuber, perilla stem and sappan wood according to the formula amount, mixing, adding water which is 5 times of the total weight of the medicinal materials, soaking for 1 hour, heating and decocting for 20 minutes, boiling and filtering; and adding 3 times of water into the medicine residues, heating to boil, filtering after boiling, combining the filtrates, and concentrating until the density is 1.02-1.2 to obtain decoction.

5. An application of the Chinese medicinal composition of claim 1 in preparing a medicament for treating common neocoronary pneumonia.