CN115869375B - Traditional Chinese medicine composition for clearing heat and dispelling wind as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for clearing heat and dispelling wind as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for clearing heat and dispelling wind, which comprises the following main active components in parts by mass: 10-15 parts of mulberry leaf, 10-15 parts of divaricate saposhnikovia root, 15-20 parts of figwort root, 15-20 parts of weeping forsythia, 15-20 parts of reed rhizome, 10-15 parts of platycodon root, 15-20 parts of radix pseudostellariae and 5-10 parts of liquorice. The traditional Chinese medicine composition for clearing heat and dispelling wind provided by the invention has the effects of dispelling wind and clearing heat, and detoxifying and relieving cough, and can be effectively used for treating symptoms such as fever, headache, sore throat, cough, yellow phlegm, thirst, red tongue with yellow fur, floating and rapid pulse and the like after novel coronavirus infection. In addition, the traditional Chinese medicine composition for clearing heat and dispelling wind provided by the invention has the advantages of taking the lung and spleen into consideration on the basis of dispelling wind, clearing heat, detoxifying and relieving cough, eliminating pathogenic factors without damaging vital qi, strengthening body resistance to assist and eliminating pathogenic factors, and can prevent the spleen and stomach from being damaged and affecting the stomach of a patient due to weakness of spleen and stomach in the south of the Ling area, thereby causing symptoms such as abdominal distention and diarrhea.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for clearing heat and dispelling wind and application thereof.
Background
In the prevention and treatment process of the novel coronavirus, the traditional Chinese medicine shows remarkable advantages. In the current diagnosis and treatment scheme of novel coronavirus infection, the prescription for treating patients with novel coronavirus infection is mostly focused on treating the novel coronavirus infection with symptoms of epidemic toxin exterior syndrome, cold-dampness depressed lung syndrome and damp-heat accumulated lung syndrome, and the prescription for targeted treatment is still lacking at present for patients with symptoms of fever, headache, sore throat, cough, yellow phlegm, thirst, red tongue fur, superficial pulse and the like after the infection of the novel coronavirus.
Therefore, a need still exists for a novel Chinese medicinal composition for treating coronavirus infection with pertinence to the syndrome of wind-heat epidemic toxin attacking lung.
Disclosure of Invention
The first aim of the invention is to provide a traditional Chinese medicine composition for clearing heat and dispelling wind, so as to solve at least one of the technical problems.
The second object of the present invention is to provide a preparation method of the traditional Chinese medicine composition, so as to solve at least one of the above technical problems.
The third object of the present invention is to provide an application of the traditional Chinese medicine composition, so as to solve at least one of the above technical problems.
According to one aspect of the invention, a traditional Chinese medicine composition for clearing heat and dispelling wind is provided, and the main active ingredients of the traditional Chinese medicine composition comprise, by mass: 10-15 parts of mulberry leaf, 10-15 parts of divaricate saposhnikovia root, 15-20 parts of figwort root, 15-20 parts of weeping forsythia, 15-20 parts of reed rhizome, 10-15 parts of platycodon root, 15-20 parts of radix pseudostellariae and 5-10 parts of liquorice.
In the formula, the mulberry leaves are sweet and cold and moist, the wind heat on the surface is slightly cleared and evacuated, and the bitter and cold is used for clearing lung heat, and the sweet and cold is used for moistening lung and dryness to relieve cough; fructus forsythiae is cool and bitter in flavor, and can be used for treating Jiao Zhure with the effect of detoxification, and both are monarch drugs, so that the fructus forsythiae can disperse wind-heat and clear upper-jiao heat. The radix sileris is slightly warm but not dry, and can help fructus forsythiae to strengthen and disperse wind heat; radix scrophulariae is salty, cold, moist and multi-liquid, and has the functions of nourishing yin, reducing pathogenic fire, detoxifying and relieving sore throat; the reed rhizome is sweet and cold in taste, is not greasy in nature, can promote the production of body fluid without loving evil, can clear lung heat, eliminate phlegm and relieve cough, can clear stomach heat and promote the production of body fluid to quench thirst, and the three medicines are ministerial medicines together, so that the drug is used for assisting monarch medicines in dispelling wind and clearing heat, and also detoxifying, relieving sore throat and promoting the production of body fluid to relieve cough. Radix Platycodi and radix Pseudostellariae are used as adjuvant drugs, radix Platycodi has effects of clearing lung-heat and relieving sore throat, and radix Pseudostellariae has effects of invigorating spleen and lung, invigorating qi and promoting fluid production. Licorice root, radix Glycyrrhizae regulates the action of other drugs as a guiding drug. The medicines are combined together to play the roles of dispelling wind, clearing heat, detoxifying and relieving cough.
The traditional Chinese medicine composition for clearing heat and dispelling wind provided by the invention can effectively relieve symptoms such as fever, headache, sore throat, cough, yellow phlegm, thirst, red tongue with yellow fur, floating pulse and the like of patients with symptoms of wind-heat epidemic toxin attacking lung after being infected by novel coronavirus, has obvious curative effects on patients with severe pharyngalgia and thirst and dry throat, does not use cold products in the formula, is used for frigidity and hurting yang qi of spleen and stomach, and is added with radix pseudostellariae and liquorice for tonifying spleen and lung, tonifying qi and promoting the production of body fluid, and simultaneously has the effects of eliminating evil and strengthening body resistance, and can not cause injury to spleen and stomach to influence stomach and cause symptoms such as abdominal distension and diarrhea for patients with weakness of spleen and stomach in the south of Ling. The traditional Chinese medicine composition for clearing heat and dispelling wind provided by the invention can be used for preparing medicines for treating novel coronavirus infection, in particular to medicines for treating patients suffering from novel coronavirus infection with syndrome of wind-heat epidemic toxin attacking lung.
The traditional Chinese medicine composition for clearing heat and dispelling wind provided by the invention closely combines the physique characteristics of the people in the south of the Ling, takes into account the lung and spleen on the basis of dispelling wind, clearing heat, detoxifying and relieving cough, and achieves the effects of eliminating pathogenic factors without damaging vital qi, strengthening body resistance to assist in eliminating pathogenic factors, and is more in accordance with the geographic climate characteristics and the pathogenesis characteristics of the areas in the south of the Ling.
In some embodiments, the traditional Chinese medicine composition for clearing heat and dispelling wind comprises the following main active components in parts by mass: 10 parts of mulberry leaf, 10 parts of divaricate saposhnikovia root, 15 parts of figwort root, 15 parts of weeping forsythiae capsule, 15 parts of reed rhizome, 10 parts of platycodon root, 20 parts of radix pseudostellariae and 5 parts of liquorice.
The traditional Chinese medicine composition for clearing heat and dispelling wind is mainly used for treating symptoms such as fever, headache, sore throat, cough, yellow phlegm, thirst, red tongue with yellow fur, floating and rapid pulse and the like after novel coronavirus infection.
The sources of the raw materials of the method are as follows:
Mulberry leaf: is dry leaf of Morus alba L. Sweet and bitter in taste and cold in nature; it enters lung and liver meridians.
Wind prevention: is root of Ledebouriella plant Ledebouriella Saposhnikovia divaricata (Turcz.) of Umbelliferae. Pungent and sweet in taste and slightly warm in nature; it enters the urinary bladder, lung, spleen and liver meridians.
Radix scrophulariae: is dried root of radix scrophulariae Scrophularia ningpoensis hemsl of Scrophulariaceae, S. buergeriana Miq. [ S. oldhami Oliv ]. Sweet, bitter and salty in taste, slightly cold in nature; it enters lung, stomach and kidney meridians.
Fructus forsythiae: is a dried fruit of fructus forsythiae Forsytniasuspensa (thunder.) Vahl belonging to genus fructus forsythiae of family Oleaceae. Bitter taste and slightly cold nature; enter lung, heart and small intestine meridians.
Reed rhizome: is fresh or dried rhizome of reed PHRAGMITES COMMUNIS Trin. Sweet in taste and cold in nature; enter lung and stomach meridians.
Radix Platycodi: is dry root of radix Platycodi Platycodon grandiflorus (Jacq.) A.DC. Bitter and pungent taste and neutral nature; enter lung meridian.
Radix pseudostellariae: is root tuber of Pseudochickweed plant of Caryophyllaceae, panax ginseng Pseudostellaria heterohylla (Miq) pax ex pax et Hoffm. Sweet and bitter in taste and neutral in nature; enter spleen and lung meridians.
Licorice root: is dry root and rhizome of Glycyrrhiza Glycyrrhiza uralensis Fisch. Glycyrrhiza uralensis Fisch. Glycyrrhiza inflata Bat. Or Glycyrrhiza glabra Glycyrrhiza glabra L. Of Glycyrrhiza of Leguminosae. Sweet in taste and neutral in nature; it enters heart, lung, spleen and stomach meridians.
In some embodiments, the dosage form of the traditional Chinese medicine composition can be decoction, tablets, capsules, granules, oral liquid or powder.
In some embodiments, pharmaceutically acceptable excipients, such as sustained release agents, excipients, fillers, binders, wetting agents, disintegrants, absorption enhancers, adsorption carriers, surfactants, lubricants, and the like, are also included.
When the Chinese medicinal composition is decoction, the preparation method can comprise the following steps:
Mixing the raw materials according to a proportion, adding 8-12 times of water by weight for soaking for 20-40 minutes, then decocting for 1-2 hours, filtering, repeatedly decocting filter residues for 1-2 times, and combining the filtrates to obtain the traditional Chinese medicine. The filtrate can be packaged after cooling, thereby being convenient to carry and distribute.
When in powder form, the preparation method can comprise the following steps:
Respectively pulverizing or shredding the raw materials, sieving the pulverized or shredded raw materials with 10 mesh and 50 mesh sieve, continuously pulverizing or shredding coarse particles which cannot pass through the 10 mesh sieve, taking powder between the 10 mesh sieve and the 50 mesh sieve, uniformly mixing the raw material powder according to a proportion, filling into a sealing bag, and sealing.
In the case of other dosage forms such as tablets, capsules, granules and the like, the preparation method can comprise the following steps:
mixing the raw materials according to a proportion to prepare extract (each 1g of extract is equivalent to 2-5g of the raw materials), adding auxiliary materials, and preparing corresponding dosage forms according to a traditional Chinese medicine conventional preparation process.
Detailed Description
The present invention will be described in further detail with reference to specific examples. The raw materials and reagents used in the present invention are commercially available unless otherwise specified.
Example 1
The traditional Chinese medicine decoction for clearing heat and dispelling wind in the embodiment is prepared from the following raw materials in each dose (about 200 mL): 10g of mulberry leaf, 10g of divaricate saposhnikovia root, 15g of figwort root, 15g of weeping forsythiae capsule, 15g of reed rhizome, 10g of platycodon root, 20g of radix pseudostellariae and 5g of liquorice.
The preparation method comprises the following steps:
Mixing the raw materials according to a certain proportion, soaking in 10 times of water for 30min, heating to boil, keeping micro boiling for 1 hr, and filtering to obtain a first decoction and residue; adding water 8 times of the total weight of the raw materials into the residue obtained after the first decoction, heating to boil, keeping micro-boiling for 1 hour, and separating to obtain a second decoction and residue; and combining the first decoction and the second decoction.
In order to verify the treatment effect of the traditional Chinese medicine composition, the invention develops clinical researches by taking the decoction of the heat-clearing wind-dispelling prescription prepared in the embodiment 1 of the invention as a test medicine, and the research process and the result are as follows:
1. Correlation standard
1.1 Diagnostic criteria
1.1.1 Western medicine disease diagnosis
With reference to the new coronavirus infection diagnosis and treatment protocol (ninth edition of trial), there is epidemiological history and clinical manifestation, which accords with etiology evidence (new coronavirus nucleic acid detection positive or antigen detection positive).
Disease typing refers to the novel diagnosis and treatment scheme for coronavirus infection (ninth edition of trial) and is classified into light, common, heavy and dangerous.
1.1.2 Criteria for diagnosis of waiting for Chinese medical Condition
Exogenous wind-heat syndrome: fever or high fever, no aversion to cold, headache, soreness of muscles, dry throat, dry mouth, bitter taste, cough, red tongue with yellow coating, and superficial and rapid pulse.
1.2 Inclusion criteria
(1) Detecting positive for the novel coronal nucleic acid or antigen;
(2) The classification standard of the novel coronavirus infection diagnosis and treatment scheme (trial ninth edition) is referred to, and the method belongs to light people.
(3) Age 18-65 years (including boundary values);
(4) Signing the informed consent.
Exclusion criteria:
(1) Acute origins of severe basal diseases or chronic diseases, such as acute heart failure, are combined.
(2) Female subjects during pregnancy, lactation or lactation;
(3) The disease affecting the duration of symptoms such as bronchopneumonia, chronic lung abscess, chronic cough for more than 8 weeks, chronic pharyngolaryngitis and cough.
3. Case withdrawal and shedding
Case withdrawal and abscission refers to cases where patients are not willing to continue to participate in clinical trials during the course of the study after entering the group or are unable to complete the full course of treatment as prescribed.
Treatment of withdrawn and exfoliated cases: the researcher should contact the subject by home visit, telephone, letter and the like, record the last treatment time and complete the completed evaluation project. And knows the reason for its exit, as recorded in the case report form. The observation data of all the withdrawn and fallen cases are reserved.
2. Case origin: a new light case of coronavirus infection diagnosed at the febrile clinic in the middle of Guangdong province during the study period.
3. Intervention and grouping:
All patients who incorporate the heat-clearing and wind-dispelling prescription take the heat-clearing and wind-dispelling prescription decoction prepared in the embodiment 1, each dose is 200mL, 1 dose is taken separately in the morning and evening 2 times, each time 100 mL is taken, and the median treatment course is 5 days.
All patients are treated according to the novel pneumonia diagnosis and treatment scheme (trial ninth edition) of coronavirus infection after entering the group, so that the basic treatment of the patients is ensured, but the antiviral treatment is not carried out.
4. Statistical methods:
The measurement data is subjected to normal test, and accords with normal average number +/-standard deviation description, normal distribution using median and quarter bit description, curative effect is successively compared, normal distribution data is subjected to paired t test, and non-normal distribution data is subjected to non-parameter test. The counting data is checked by using a chi-square.
5. Test results
1. Baseline analysis
Baseline data for the patients are shown in table 1:
Table 1 baseline profile for patients
As shown in table 1, the two groups of sex distribution are balanced, and compared with the control group without taking the heat-clearing and wind-dispelling prescription decoction, the patients in the heat-clearing and wind-dispelling prescription group are older; the time from onset to follow-up is obviously shorter than that of a control group, and the control group uses more combined medicines, in particular to cough relieving and phlegm reducing medicines.
2. The symptoms of the patients at the time of disease are shown in Table 2
TABLE 2 patient's onset symptoms form
As shown in table 2, the top four symptoms of the heat-clearing and wind-dispelling prescription group were fever, cough, nasal obstruction/nasal discharge and sore throat; the highest symptom of the prescription with the functions of clearing heat and dispelling wind is fever, the proportion is 89.2 percent, and the cough with the second symptom (76.4 percent) takes advantage of the symptom.
3. Symptom disappearance condition table after patient uses medicine
Table 3 patient symptom disappearance evaluation scale
As shown in table 3, compared with the control group, the heat-clearing and wind-dispelling prescription has better effects on fever, chill/chills, and the difference has statistical significance; the relief effect against shortness of breath/dyspnea was also better than the control group, but the differences had not reached statistically significant levels.
4. Symptom disappearance schedule after administration of the drug to the patient
TABLE 4 evaluation of time to disappearance of symptoms in patients
As shown in table 4, the heat-clearing and wind-dispelling prescription group significantly shortened the fever time of the patient (2 days vs 4 days, p=0.01) relative to the control group, and also had a shortening effect on the tiredness time of the patient (4 days vs7.5 days, p=0.092), but the difference did not reach a statistically significant level.
5. Residual symptom table after treatment of patient
Table 5 table of residual symptoms after patient treatment
As shown in Table 5, the main residual symptoms after the treatment of the heat-clearing and wind-dispelling prescription are cough, the comparison group accounts for 78.7 percent, the heat-clearing and wind-dispelling prescription accounts for 62.2 percent, and the symptoms except cough after the treatment of each group are nasal obstruction/nasal discharge, sore throat and tiredness are all less than 10 percent.
6. Conclusion:
(1) After 5 days of treatment by taking the heat-clearing wind-dispelling prescription, the symptoms of the patients are obviously improved, and the difference has statistical significance.
(2) The formula of clearing heat and dispelling wind can obviously relieve cough and other symptoms of patients, and obviously shorten the disappearance time of various symptoms.
What has been described above is merely some embodiments of the present invention. It will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the spirit of the invention.
Claims (8)
1. The traditional Chinese medicine composition for clearing heat and dispelling wind is characterized by being prepared from the following raw material medicines in parts by mass: 10-15 parts of mulberry leaf, 10-15 parts of divaricate saposhnikovia root, 15-20 parts of figwort root, 15-20 parts of weeping forsythia, 15-20 parts of reed rhizome, 10-15 parts of platycodon root, 15-20 parts of radix pseudostellariae and 5-10 parts of liquorice.
2. The traditional Chinese medicine composition for clearing heat and dispelling wind according to claim 1, which is characterized by being prepared from the following raw materials in parts by mass: 10 parts of mulberry leaf, 10 parts of divaricate saposhnikovia root, 15 parts of figwort root, 15 parts of weeping forsythiae capsule, 15 parts of reed rhizome, 10 parts of platycodon root, 20 parts of radix pseudostellariae and 5 parts of liquorice.
3. The traditional Chinese medicine composition for clearing heat and dispelling wind according to claim 1 or 2, wherein the traditional Chinese medicine composition is in the form of decoction, tablets, capsules, granules, oral liquid or powder.
4. The traditional Chinese medicine composition for clearing heat and dispelling wind according to claim 3, further comprising pharmaceutically acceptable auxiliary materials.
5. The traditional Chinese medicine composition for clearing heat and dispelling wind according to claim 4, wherein the pharmaceutically acceptable auxiliary materials are at least one selected from sustained release agents, filling agents, adhesives, wetting agents, disintegrating agents, absorption promoters, adsorption carriers, surfactants and lubricants.
6. The preparation method of the traditional Chinese medicine composition for clearing heat and dispelling wind as claimed in claim 3, wherein when the traditional Chinese medicine composition is a decoction, the preparation method comprises the following steps:
mixing the raw materials according to a proportion, adding 8-12 times of water by weight for soaking for 20-40 minutes, then decocting for 1-2 hours, filtering, repeatedly decocting filter residues for 1-2 times, and combining the filtrates to obtain the traditional Chinese medicine.
7. The use of a Chinese medicinal composition for clearing heat and dispelling wind as claimed in any one of claims 1-5 in the preparation of a medicament for treating novel coronavirus infection.
8. The use according to claim 7, wherein the novel coronavirus infection is a wind-heat epidemic virus-attacks-lung-syndrome type novel coronavirus infection.
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