CN102335243B

CN102335243B - Chinese medicinal composition for treating icteric hepatitis

Info

Publication number: CN102335243B
Application number: CN 201110313320
Authority: CN
Inventors: 潘月玲; 战祥峰; 潘月娜
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-10-17
Filing date: 2011-10-17
Publication date: 2013-01-16
Anticipated expiration: 2031-10-17
Also published as: CN102335243A

Abstract

The invention discloses a Chinese medicinal composition for treating icteric hepatitis. The composition consists of virgate wormwood herb, Chinese rhubarb, ageratum, fortune eupatorium herb, Chinese angelica, the rhizome of Chinese atractylode, bighead atractylodes rhizome, prepared common monkshood daughter root and liquorice, has the efficacies of clearing away heat and expelling toxic materials, drying dampness and strengthening spleen, and has a short course of treatment, a remarkable curative effect and no toxic or side effect. According to the statistics on observation to 125 clinical patients, the total effective rate of the patients taking the medicament for one course of treatment is 86.4 percent, while the total effective rate of the patients taking the medicament for two courses of treatment is 94.4 percent.

Description

A kind of Chinese medicine composition for the treatment of icterohepatitis

Technical field

The present invention relates to a kind of Chinese medicine composition, especially a kind of Chinese medicine composition for the treatment of icterohepatitis.

Background technology

The traditional Chinese medical science thinks, jaundice is to be obstructed by the liver and gall mechanism of qi, and catharsis is not normal.Bile is excessive, the disease of liver-gallbladder take icteric sclera, yellowish body, yellowish urine as main manifestations.Its cause of disease has the seasonal pathogen of impression epidemic disease poison, or is injury due to diet, or is weakness of the spleen and stomach, and it is suffered from inside and outside often occuring mutually each other.Mainly be damp from pathogenic factor, such as " Medical Treasures of the Golden Chamber, Shanghai: jaundice abnormal pulse card is also controlled " " yellow family gained, caused by pathogenic dampness " arranged.And among the internal organs, the transporting that taste master water is wet is therefore the prosperity and decline of the morbidity of jaundice and spleen and stomach function has close relationship.At present, the Western medicine for the treatment of icterohepatitis class is mainly and suppresses viral the liver protecting and ALT lowering, and from current, these medicines are scarcely desirable, middle medical drugs is uneven again, mix the genuine with the fictitious, be difficult to gather effect, delay the state of an illness, in the course of time become chronic hepatitis, the criminal controls for a long time for a long time, obstinate, even be converted into liver cirrhosis so that canceration.

Summary of the invention

Main task of the present invention provides a kind of Chinese medicine composition for the treatment of icterohepatitis, and this medicine has heat-clearing and toxic substances removing, drying damp and strengthening spleen effect.

The present invention selects Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Herba Pogostemonis, Herba Eupatorii, Radix Angelicae Sinensis, the Rhizoma Atractylodis Rhizoma Atractylodis Macrocephalae, Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae to make up, with these drug regimens so that each efficacy of drugs produces synergism, make it to have heat-clearing and toxic substances removing, drying damp and strengthening spleen effect, thereby can effectively treat icterohepatitis.

Wherein, Herba Artemisiae Scopariae: be the seedling of feverfew Herba Artemisiae Scopariae Artemisia capillaris Thunb..Cold nature, acrid in the mouth, hardship.Return spleen, stomach, liver, gallbladder meridian.Has clearing away damp-heat, the effect of jaundice eliminating subcutaneous ulcer.Be used for jaundice oliguria, infectious jaundice type hepatitis.Herba Artemisiae Scopariae has significant hepatoprotective effect, to first, and hepatitis B, icterohepatitis has significant curative effect.Function of gallbladder promoting is arranged, promote bile secretion, the effect that cholic acid and bilirubin are discharged in the increase bile.

Radix Et Rhizoma Rhei: be root and the rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Nature and flavor, hardship, cold.Return stomach, Liver Channel, spleen channel.Has clearing away damp-heat, removing heat from blood, the effect of detoxifcation.

Herba Pogostemonis: be the labiate Herba Pogostemonis Agastache rugosaThe aerial parts of (Fisch. et Mey.) O. Ktze..Acrid in the mouth; Slightly warm in nature.Return lung; Spleen; The stomach warp.Effect with dispelling summer-heat from superficies of the body, removing dampness to restore normal function of the stomach.

Herba Eupatorii: be the aerial parts of feverfew Herba Eupatorii (Herba Chlorophyti) Eupatorium fortunei Turcz..Nature and flavor are hot, and are flat.Return spleen, stomach, lung meridian.Effect with clearing away heat and eliminating dampness, anti inflammatory detoxication.

Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Warm in nature, sweet in the mouth, suffering.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, the effect of loosening bowel to relieve constipation.Hepatic injury there is protective effect, and can promotes liver cell regeneration and the effect that recovers some function of liver.

Rhizoma Atractylodis: be the Compositae herbaceos perennial, the rhizome of Atractylodes lancea (Thunb.) DC. (RHIZOMA ATRACTYLODIS IANCEAE) or Atractylis chinensis.Nature and flavor are hot, bitter, temperature.Return spleen, stomach, Liver Channel.Have drying damp and strengthening spleen, the effect of expelling wind and cold.

The Rhizoma Atractylodis Macrocephalae: be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor are bitter, sweet, temperature.Return spleen, stomach warp.Effect with invigorating the spleen and benefiting QI, dampness diuretic.

Radix Aconiti Lateralis Preparata: be the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. aconitum carmichaeli debx..Nature and flavor are hot, sweet, large heat; Poisonous.GUIXIN, kidney, spleen channel.

Radix Glycyrrhizae: be dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensisFisch., Glycyrrhiza inflata Bat. G. inflataOr Glycyrrhiza glabra L. Bat., G. glabraL. root and rhizome.Property is put down, and sweet in the mouth is returned 12 warps.Has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, the effect of coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness has antiinflammatory, antiviral, and the effects such as protecting liver and detoxication and enhancing immunologic function.Because glycyrrhizic acid has the pharmacological action of glucocorticoid sample and without serious adverse reaction, clinically be widely used in treating the functions such as various acute, chronic hepatitis, interferon inducer and cell immunomodulator.

Medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each material medicine consumption all has preferably therapeutic effect in the scope of following weight parts: 10-20 parts of Herba Artemisiae Scopariaes, 5-15 parts of Radix Et Rhizoma Rhei, 10-20 parts of Herba Pogostemoniss, 10-20 parts of Herba Eupatoriis, 10-20 parts of Radix Angelicae Sinensis, 10-20 parts of Rhizoma Atractylodis, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 3-8 parts of Radix Aconiti Lateralis Preparatas, 1-5 parts in Radix Glycyrrhizae.

It is preferably: 15 parts of Herba Artemisiae Scopariaes, 9 parts of Radix Et Rhizoma Rhei, 15 parts of Herba Pogostemoniss, 15 parts of Herba Eupatoriis, 15 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Atractylodis, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Radix Aconiti Lateralis Preparatas, 3 parts in Radix Glycyrrhizae.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, such as pill, powder, tablet, capsule, oral liquid etc.For example, these medicine material grind into powder mix homogeneously can be made powder takes after mixing it with water; Can use decocting, get after filtration filtrate, add antiseptic and make oral liquid; Also can directly take decoction in case of necessity.

The specific embodiment

Embodiment one, 10 parts of Herba Artemisiae Scopariaes, 5 parts of Radix Et Rhizoma Rhei, 10 parts of Herba Pogostemoniss, 10 parts of Herba Eupatoriis, 10 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Atractylodis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts of Radix Aconiti Lateralis Preparatas, 1 part in Radix Glycyrrhizae.

Embodiment two, 15 parts of Herba Artemisiae Scopariaes, 9 parts of Radix Et Rhizoma Rhei, 15 parts of Herba Pogostemoniss, 15 parts of Herba Eupatoriis, 15 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Atractylodis, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Radix Aconiti Lateralis Preparatas, 3 parts in Radix Glycyrrhizae.

Embodiment three, 20 parts of Herba Artemisiae Scopariaes, 15 parts of Radix Et Rhizoma Rhei, 20 parts of Herba Pogostemoniss, 20 parts of Herba Eupatoriis, 20 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Atractylodis, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Radix Aconiti Lateralis Preparatas, 5 parts in Radix Glycyrrhizae.

The below is the clinical statistics data that the patient uses medicine of the present invention:

One, physical data

Accept 125 examples for medical treatment and be in hospital and the out-patient, wherein, male's 78 examples, women's 47 examples, 36 years old mean age, all cases all meets the icterohepatitis diagnostic criteria of nineteen ninety-five infectious disease parasitic disease association formulation.

Two, diagnostic criteria

Fear of cold, heating, weak, loss of appetite, nausea and vomiting, detest oil, pale tongue with thin fur is white and slide thready and moderate pulse.There are in various degree skin yellow sclera, urine buff, most of case to have liver pain and percussion pain, hepatomegaly, liver function test to show that the some patients were routine blood test is unusual significantly unusually within one week.

Three, Therapeutic Method

Take embodiment two as example, according to the drug weight part weighting raw materials (daily dose) among the embodiment two, carry out decocting with the decocting method of Chinese medicine decoction routine, filter and remove residue is taken at twice, sooner or later each once, seven is a course for the treatment of.

Four, efficacy assessment standard

Produce effects: patient's fear of cold, weak, poor appetite, feel sick, clinical fundamental symptoms and the sign complete obiteration such as yellowish urine, observing jaundice disappears, bilirubin, transaminase level all recover normally substantially;

Effectively: patient's fear of cold, weak, poor appetite, feel sick, the clinical fundamental symptoms such as yellowish urine alleviates to some extent with sign, observes jaundice to shoal to some extent, bilirubin, transaminase level all have obvious decline before the treatment but recover normally;

Invalid: patient's clinical fundamental symptoms and sign, the performance of observation jaundice, bilirubin level, transaminase level are treated front nothing significantly improvement or to some extent deterioration.

Five, treatment statistical result

Figure 2011103133209100002DEST_PATH_IMAGE001

Total effective rate=(produce effects+effectively)/total routine number * 100%.

Model case:

1, Chen, woman, people from Juxian County, 42 years old, because the unable 1 week companion xanthochromia of anorexia occurred together hot 3 days, medical on June 8th, 2010, the patient is medical doctor trained in Western medicine internal clinic first, and through the liver function chemical examination, the result shows icterohepatitis, change the treatment of my section over to, the patient except above-mentioned symptom, the time have right flank section dull pain uncomfortable, nauseating nausea, yellow urine, stool is normal, the red tongue tongue is greasy in vain, slippery and rapid pulse.Tcm diagnosis is jaundice (damp and hot laying equal stress on), uses prescription of the present invention, minute morning, late twice decoction being taken warmly behind 2 mixings of decocting, 1 day 1 dose, after taking medicine 3 days, sclera, xanthochromia is clearly better, symptom also has and alleviates, after taking 3 doses, xanthochromia and transference cure, the blood test liver function is normal, the patient disease recovery from illness is gone back with satisfaction.

2, Zhang, man, people from Juxian County, 35 years old, because of xanthochromia, enter the treatment of my section, fear of cold, heating, weak, loss of appetite, nausea and vomiting are arranged, detest the wet goods symptom, pale tongue with thin fur is slided in vain, and thready and moderate pulse, tcm diagnosis are jaundice (damp and hot laying equal stress on), use prescription of the present invention, behind 2 mixings of decocting minute early, late twice decoction being taken warmly, 1 day 1 dose, xanthochromia is clearly better after taking medicine 7, and symptom also alleviates to some extent, after taking 3 doses, xanthochromia and transference cure, the blood test liver function is normal, the patient disease recovery from illness.

Claims

1. a Chinese medicine composition for the treatment of icterohepatitis is characterized in that being comprised of the crude drug of following weight portion: 10-20 parts of Herba Artemisiae Scopariaes, 5-15 parts of Radix Et Rhizoma Rhei, 10-20 parts of Herba Pogostemoniss, 10-20 parts of Herba Eupatoriis, 10-20 parts of Radix Angelicae Sinensis, 10-20 parts of Rhizoma Atractylodis, 10-20 parts of the Rhizoma Atractylodis Macrocephalaes, 3-8 parts of Radix Aconiti Lateralis Preparatas, 1-5 parts in Radix Glycyrrhizae.

2. the Chinese medicine composition for the treatment of icterohepatitis according to claim 1, the weight portion that it is characterized in that each crude drug is 15 parts of Herba Artemisiae Scopariaes, 9 parts of Radix Et Rhizoma Rhei, 15 parts of Herba Pogostemoniss, 15 parts of Herba Eupatoriis, 15 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Atractylodis, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Radix Aconiti Lateralis Preparatas, 3 parts in Radix Glycyrrhizae.