CN114224948A - A Chinese medicinal composition for treating new coronavirus, and its preparation method - Google Patents
A Chinese medicinal composition for treating new coronavirus, and its preparation method Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
A Chinese medicinal composition with therapeutic effect on new coronavirus and its preparation method, its technical scheme is as follows: comprises the following components: dahurian angelica root oil, magnolia flower oil, magnolia bark oil, tangerine peel oil, isatis root, cimicifuga rhizome, patchouli oil and coptis root. The invention relates to a traditional Chinese medicine composition with curative effect on new coronavirus, which adopts angelica dahurica oil, magnolia flower oil, magnolia bark oil, tangerine peel oil, isatis root, cimicifuga foetida, patchouli oil and coptis as main components, and one or more of forsythia suspensa oil, sandalwood oil, notopterygium oil and argy wormwood leaf oil as auxiliary components, wherein the components interact with one another, so that the traditional Chinese medicine composition is nontoxic and safe, and the active pharmacodynamic components have obvious killing effect on SARS-CoV-2 coronavirus, so that the traditional Chinese medicine composition has good effect when used for preparing a medicine for preventing or treating coronavirus diseases, can effectively prevent the existing new coronavirus from invading and relieve infection symptoms.
Description
[ technical field ] A method for producing a semiconductor device
The invention belongs to the field of traditional Chinese medicine application, and particularly relates to a traditional Chinese medicine composition with curative effect on new coronavirus and a preparation method thereof.
[ background of the invention ]
Novel coronaviruses, in particular SARS-CoV-2, are found, which are known as infectious acute respiratory syndrome (TARS coronavirus), clustered acute respiratory syndrome coronavirus (CARS coronavirus), or rapidly spreading respiratory syndrome coronavirus (RARS-COV)), and are persistently epidemic, and infections of which are mostly without significant clinical symptoms or exhibit common cold-like symptoms, and a minority can develop into pneumonia. The novel coronavirus (SARS-CoV-2) belongs to the beta genus coronavirus in the family Coronaviridae, and the gene characteristics are obviously different from those of SARSr-CoV and MERSR-CoV. The virus is sensitive to ultraviolet rays and heat, and can be effectively inactivated by lipid solvents such as 75% ethanol, chlorine-containing disinfectants, peracetic acid, chloroform and the like. Based on the current epidemiological investigation and research results, the infection source is mainly a patient infected by the novel coronavirus, and asymptomatic infectors can also become the infection source; the main transmission route is via respiratory droplets and contact transmission, the possibility of aerosol transmission exists under the condition of long-time exposure to high-concentration aerosol in a relatively closed environment, and other transmission routes are yet to be determined. In terms of treatment, common pneumonia mostly has high fever as a main symptom, so the used traditional Chinese medicines mostly have large dose of heat-clearing and toxicity-removing medicines as main medicines. The new coronary pneumonia is mainly low-grade fever, the lung fails to disperse and descend, and belongs to deficiency syndrome, so the new coronary pneumonia is not suitable for large-dose cold and cool medicines. Therefore, the traditional Chinese medicine treatment scheme for common pneumonia is not suitable for treating the new coronary pneumonia.
[ summary of the invention ]
The invention discloses a traditional Chinese medicine composition with curative effect on new coronavirus, which can effectively prevent the existing new coronavirus from invading and relieve infection symptoms.
The invention discloses a preparation method of a traditional Chinese medicine composition with a curative effect on new coronavirus.
A Chinese medicinal composition with therapeutic effect on new coronavirus comprises the following components: dahurian angelica root oil, magnolia flower oil, magnolia bark oil, tangerine peel oil, isatis root, cimicifuga rhizome, patchouli oil and coptis root.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 8-30 parts of angelica dahurica oil, 8-30 parts of magnolia flower oil, 8-30 parts of magnolia bark oil, 8-30 parts of tangerine peel oil, 8-12 parts of isatis root, 10-14 parts of cimicifuga foetida, 8-10 parts of patchouli oil and 7-11 parts of coptis chinensis.
Preferably, the traditional Chinese medicine composition also comprises the following components: at least one of weeping Forsythia oil, Sandalwood oil, Notopterygii rhizoma oil and folium Artemisiae Argyi oil.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: comprises the following components: 8-30 parts of angelica dahurica oil, 8-30 parts of magnolia flower oil, 8-30 parts of magnolia bark oil, 8-30 parts of tangerine peel oil, 8-12 parts of isatis root, 10-14 parts of cimicifuga foetida, 8-10 parts of patchouli oil, 7-11 parts of coptis chinensis, 8-12 parts of forsythia suspense oil and 6-9 parts of sandalwood oil.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 8-30 parts of angelica dahurica oil, 8-30 parts of magnolia flower oil, 8-30 parts of magnolia bark oil, 8-30 parts of tangerine peel oil, 8-12 parts of isatis root, 10-14 parts of cimicifuga foetida, 8-10 parts of patchouli oil, 7-11 parts of coptis chinensis and 6-9 parts of notopterygium oil.
Preferably, the radix Angelicae Dahuricae oil is volatile oil extracted from root of Angelica dahurica of Angelica of Umbelliferae;
the flos Magnoliae oil is volatile oil extracted from dried flower bud of Magnolia biondii, Magnolia denudata or Magnolia wudangensis of Magnolia of Magnoliaceae;
the Magnolia officinalis oil is volatile oil extracted from dried bark, root bark and branch bark of Magnolia officinalis or Magnolia obovata Thunb of Magnoliaceae;
the tangerine peel oil is volatile oil extracted from dried mature pericarp of Citrus reticulata and its cultivar of Rutaceae;
the oleum forsythiae is volatile oil extracted from dried fruit of Forsythia suspensa (Thunb.) Vahl of Oleaceae;
the oleum herba Pogostemonis is volatile oil extracted from dried stem and leaf of herba Pogostemonis of Labiatae;
the oleum folium Artemisiae Argyi is volatile oil extracted from dry leaf or fresh leaf of Artemisia princeps Pampanini of Compositae, and its main effective components are typhinol-4 and alpha-terpinenol. The blumea oil is a natural antibacterial agent, has a wide antibacterial spectrum, and has antibacterial activity on bacteria, fungi and viruses. The blumea oil has the effects of clearing away heat and toxic materials, resisting allergy, eliminating dampness, treating eczema and the like.
The notopterygium oil is volatile oil extracted from rhizome and root of Notopterygium incisum or Notopterygium forbesii of Notopterygium of Umbelliferae. The notopterygium oil is one of the effective components of traditional Chinese medicine notopterygium, has wide pharmacological activity, and has the effects of resisting inflammation, relieving pain, relieving fever, inhibiting bacteria, resisting allergy and the like.
The sandalwood oil is volatile oil obtained by distilling heartwood of Santalum album of Santalaceae.
Preferably, the volatile oil extraction method comprises the following steps:
(1) raw material treatment: chopping the dried raw materials in the shade and putting into an extraction tank;
the concrete operation of the steps is as follows: drying the raw materials in the shade, air drying until the water content is less than 10%, chopping the dried raw materials in the shade to keep the size of the leaves at 2-3cm, and putting the chopped raw materials into an extraction tank;
(2) direct steam: opening a straight-through steam valve of the extraction tank, introducing steam into the extraction tank, adjusting the steam pressure, and controlling the straight-through heating time and the tank body extraction temperature;
the steam pressure regulation comprises a first steam pressure regulation and a second steam pressure regulation, in the step (2), a straight-through steam valve of the extraction tank is opened, after steam is introduced into the extraction tank, the steam pressure is regulated for the first time, and after an oil-water mixture comes out, the steam pressure is regulated for the second time, wherein the steam pressure for the second steam pressure regulation is smaller than the steam pressure for the first steam pressure regulation, the first steam pressure regulation is used for evaporating the oil-water mixture in the ginger raw material, the quality of the extracted volatile oil is better, the second steam pressure regulation can fully evaporate the raw material, the product yield is improved, and the content of the volatile oil reaches 0.7%;
preferably, the steam pressure of the regulated steam pressure in the step (2) is 0.02-0.03MPa, the straight-through heating time is 1-2h, and the tank body extraction temperature is 90-100 ℃;
(3) separation: and condensing the oil-water mixture steamed by the steam, and separating in an oil-water separator to collect an oil layer. In the method, when the raw material is treated, the raw material is dried in the shade until the water content is lower than 10 percent and the chopped blades are kept at 3-5cm, so that the raw material can be fully evaporated in the direct steam treatment, and the product yield is favorably improved.
A preparation method of a traditional Chinese medicine composition with curative effect on new coronavirus comprises the following steps: accurately weighing radix Isatidis, cimicifugae rhizoma, Coptidis rhizoma, pulverizing, mixing with radix Angelicae Dahuricae oil, flos Magnoliae oil, cortex Magnolia officinalis oil, pericarpium Citri Tangerinae oil, radix Isatidis, and oleum herba Pogostemonis, or fructus forsythiae oil, lignum Santali albi oil, Notopterygii rhizoma oil and folium Artemisiae Argyi oil, mixing at a certain weight ratio, and making into corresponding preparations in the form of dripping pill, injection, unguent, mixture, gel, tablet, granule, pellet, aerosol, emulsion, microsphere, nanosphere, oral liquid, suspension or suppository.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine composition with curative effect on the new corona virus adopts angelica dahurica oil, magnolia flower oil, magnolia bark oil, tangerine peel oil, isatis root, cimicifuga foetida, patchouli oil and coptis as main components and one or more of forsythia suspensa oil, sandalwood oil, notopterygium oil and argy wormwood leaf oil as auxiliary components, and the components interact with each other, so that the traditional Chinese medicine composition is nontoxic and safe, and the active drug effect components have obvious killing effect on SARS-CoV-2 coronavirus, the compound has good effect when being used for preparing the medicine for preventing or treating the coronavirus diseases, and can be used for preparing the medicine products for treating or preventing new coronary pneumonia, complications and sequelae of the new coronary pneumonia, preventing or treating interstitial pneumonia, preventing or treating pulmonary fibrosis caused by the new coronary pneumonia, and promoting the pulmonary function recovery of patients with the new coronary pneumonia or/and promoting the pulmonary inflammation absorption of the patients with the new coronary pneumonia.
[ detailed description ] embodiments
The preparation and use of a Chinese medicinal composition having therapeutic effects on new coronavirus according to the present invention are described with reference to specific examples 1-5.
Examples 1 to 5:
a Chinese medicinal composition with therapeutic effect on new coronavirus is prepared by the following steps:
selecting traditional Chinese medicine raw materials, and collecting volatile oil by a steam purification method, wherein the specific raw materials are as follows:
selecting root of Angelica dahurica of Angelica of Umbelliferae as raw material for extracting radix Angelicae Dahuricae oil, selecting dried flower bud of Magnolia of Magnoliaceae, Magnolia or Magnolia wushuensis as raw material for extracting Magnolia oil, selecting dried bark, root bark and branch bark of Magnolia officinalis or Magnolia biloba of Magnoliaceae as raw material for extracting Magnolia oil, selecting dried mature pericarp of Citrus reticulata of Rutaceae and its cultivar as raw material for extracting pericarpium Citri Tangerinae oil;
or selecting dry fruit of Forsythia suspensa of Oleaceae as Forsythia suspensa oil extraction raw material, selecting dry stem and leaf of Pogostemon cablin of Labiatae as Pogostemon cablin oil extraction raw material, selecting dry leaf or fresh leaf of Artemisia argyi of Compositae as Artemisia argyi oil extraction raw material, selecting rhizome and root of Notopterygium incisum or Notopterygium forbesii of Notopterygium of Umbelliferae as notopterygium root oil extraction raw material;
the volatile oil is extracted from the raw materials by the following steps:
(1) raw material treatment: chopping the dried raw materials in the shade and putting into an extraction tank;
the concrete operation of the steps is as follows: drying the raw materials in the shade, air drying until the water content is less than 10%, chopping the dried raw materials in the shade to keep the size of the leaves at 2-3cm, and putting the chopped raw materials into an extraction tank;
(2) direct steam: opening a straight-through steam valve of the extraction tank, introducing steam into the extraction tank, adjusting the steam pressure, and controlling the straight-through heating time and the tank body extraction temperature;
the steam pressure regulation comprises a first steam pressure regulation and a second steam pressure regulation, in the step (2), a straight-through steam valve of the extraction tank is opened, after steam is introduced into the extraction tank, the steam pressure is regulated for the first time, and after an oil-water mixture comes out, the steam pressure is regulated for the second time, wherein the steam pressure for the second steam pressure regulation is smaller than the steam pressure for the first steam pressure regulation, the first steam pressure regulation is used for evaporating the oil-water mixture in the ginger raw material, the quality of the extracted volatile oil is better, the second steam pressure regulation can fully evaporate the raw material, the product yield is improved, and the content of the volatile oil reaches 0.7%;
preferably, the steam pressure of the regulated steam pressure in the step (2) is 0.02-0.03MPa, the straight-through heating time is 1-2h, and the tank body extraction temperature is 90-100 ℃;
(3) separation: condensing the oil-water mixture evaporated by the steam, and separating in an oil-water separator to collect an oil layer;
table 1: the raw material compositions described in examples 1 to 5 are as follows
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | |
| Angelica dahurica oil | 25 portions of | 17 portions of | 19 portions of | 22 portions of | 20 portions of |
| Magnolia flower oil | 20 portions of | 15 portions of | 28 portions of | 22 portions of | 18 portions of |
| Magnolia bark oil | 22 portions of | 20 portions of | 15 portions of | 12 portions of | 25 portions of |
| Tangerine peel oil | 12 portions of | 13 portions of | 13 portions of | 15 portions of | 20 portions of |
| Radix Isatidis | 10 portions of | 10 portions of | 15 portions of | 12 portions of | 8 portions of |
| Cimicifugae foetidae | 14 portions of | 12 portions of | 12 portions of | 10 portions of | 10 portions of |
| Patchouli oil | 12 portions of | 11 portions of | 10 portions of | 15 portions of | 12 portions of |
| Coptis chinensis | 10 portions of | 7 portions of | 8 portions of | 11 portions of | 9 portions of |
| Forsythia oil | 12 portions of | 8 portions of | 0 portion of | 12 portions of | 10 portions of |
| Sandalwood oil | 8 portions of | 7 portions of | 0 portion of | 6 portions of | 9 portions of |
| Qiang Huo oil | 0 portion of | 0 portion of | 11 portions of | 7 portions of | 0 portion of |
| Folium Artemisiae Argyi oil | 0 portion of | 5 portions of | 0 portion of | 12 portions of | 8 portions of |
Accurately weighing radix Isatidis, cimicifugae rhizoma, Coptidis rhizoma, pulverizing, mixing with radix Angelicae Dahuricae oil, flos Magnoliae oil, cortex Magnolia officinalis oil, pericarpium Citri Tangerinae oil, radix Isatidis, and oleum herba Pogostemonis, or fructus forsythiae oil, lignum Santali albi oil, Notopterygii rhizoma oil and folium Artemisiae Argyi oil, mixing at a certain weight ratio, and making into corresponding preparations in the form of dripping pill, injection, unguent, mixture, gel, tablet, granule, pellet, aerosol, emulsion, microsphere, nanosphere, oral liquid, suspension or suppository.
The application provides the effect record of the traditional Chinese medicine composition for treating the new coronary pneumonia, which has the curative effect on the new coronary viruses, on the actual patient.
Typical cases are:
1. patient lithe, male, age 47, symptoms: after the traditional Chinese medicine combined dripping pill provided by the embodiment 1 of the invention is taken for two doses every day, the body temperature is reduced to normal 7 days later, and the symptoms related to the new coronary pneumonia are obviously weakened; after the application is continued for 7 days, the virus nucleic acid detection is negative, and the new coronary pneumonia is not shown in the chest imaging;
2. patient Zhangyi, female, age 37, symptoms: continuous cough and repeated fever are caused, two doses of the traditional Chinese medicine combined dripping pill medicine provided by the embodiment 3 of the invention are taken every day, after 5 days, the body temperature is reduced to normal, and the symptoms related to the new coronary pneumonia are eliminated; after the application is continued for 7 days, the virus nucleic acid detection is negative, and the new coronary pneumonia is not shown in the chest imaging;
3. patient wangzhi, male, age 33, symptoms: after 4 days, the body temperature is reduced to normal, and the symptoms related to the new coronary pneumonia are relieved; after the application for 7 days, the virus nucleic acid detection is negative, and no new coronary pneumonia is shown in the chest imaging.
The traditional Chinese medicine composition with curative effect on the new coronavirus adopts angelica dahurica oil, magnolia flower oil, magnolia bark oil, tangerine peel oil, isatis root, cimicifuga foetida, patchouli oil and coptis as main components, and one or more of forsythia oil, sandalwood oil, notopterygium oil and argy wormwood leaf oil as auxiliary components, and the components interact with each other, so that the traditional Chinese medicine composition is nontoxic and safe, and the active pharmacodynamic components have obvious killing effect on SARS-CoV-2 coronavirus, and have good effect when being used for preparing the medicine for preventing or treating coronavirus diseases. The above results demonstrate that the Chinese medicinal composition of the present invention can effectively treat neocoronavirus infection.
Claims (9)
1. A traditional Chinese medicine composition with curative effect on new coronavirus is characterized by comprising the following components: dahurian angelica root oil, magnolia flower oil, magnolia bark oil, tangerine peel oil, isatis root, cimicifuga rhizome, patchouli oil and coptis root.
2. The traditional Chinese medicine composition with curative effect on the new coronavirus according to claim 1, which is characterized by comprising the following components in parts by weight: 12-25 parts of angelica dahurica oil, 15-28 parts of magnolia flower oil, 12-25 parts of magnolia bark oil, 10-20 parts of tangerine peel oil, 8-15 parts of isatis root, 10-14 parts of cimicifuga foetida, 10-15 parts of patchouli oil and 7-11 parts of coptis chinensis.
3. The Chinese medicinal composition for treating new coronavirus according to claim 1, further comprising the following components: at least one of weeping Forsythia oil, Sandalwood oil, Notopterygii rhizoma oil and folium Artemisiae Argyi oil.
4. The traditional Chinese medicine composition with curative effect on the new coronavirus according to claim 3, which is characterized by comprising the following components in parts by weight: 8-30 parts of angelica dahurica oil, 8-30 parts of magnolia flower oil, 8-30 parts of magnolia bark oil, 8-30 parts of tangerine peel oil, 8-12 parts of isatis root, 10-14 parts of cimicifuga foetida, 8-10 parts of patchouli oil, 7-11 parts of coptis chinensis, 8-12 parts of forsythia suspense oil and 6-9 parts of sandalwood oil.
5. The traditional Chinese medicine composition with curative effect on the new coronavirus according to claim 3, which is characterized by comprising the following components in parts by weight: 8-30 parts of angelica dahurica oil, 8-30 parts of magnolia flower oil, 8-30 parts of magnolia bark oil, 8-30 parts of tangerine peel oil, 8-12 parts of isatis root, 10-14 parts of cimicifuga foetida, 8-10 parts of patchouli oil, 7-11 parts of coptis chinensis and 6-9 parts of notopterygium oil.
6. The Chinese medicinal composition for treating new coronavirus according to claim 1, wherein the angelica dahurica oil is volatile oil extracted from the root of angelica dahurica of angelica of family Umbelliferae;
the flos Magnoliae oil is volatile oil extracted from dried flower bud of Magnolia biondii, Magnolia denudata or Magnolia wudangensis of Magnolia of Magnoliaceae;
the Magnolia officinalis oil is volatile oil extracted from dried bark, root bark and branch bark of Magnolia officinalis or Magnolia obovata Thunb of Magnoliaceae;
the tangerine peel oil is volatile oil extracted from dried mature pericarp of Citrus reticulata and its cultivar of Rutaceae,
the oleum herba Pogostemonis is volatile oil extracted from dried stem and leaf of herba Pogostemonis of Labiatae.
7. The Chinese medicinal composition for treating a neocoronaviruse according to claim 3, wherein the forsythia oil is volatile oil extracted from dried fruits of forsythia suspense belonging to the family of Oleaceae;
the sandalwood oil is volatile oil obtained by distilling heartwood of Santalum album of Santalaceae;
the oleum folium Artemisiae Argyi is volatile oil extracted from dry leaf or fresh leaf of Artemisia princeps Pampanini of Compositae;
the notopterygium oil is volatile oil extracted from rhizome and root of Notopterygium incisum or Notopterygium forbesii of Notopterygium of Umbelliferae.
8. The herbal composition of claim 6 or 7, wherein the method for extracting essential oil comprises the steps of:
(1) raw material treatment: chopping the dried raw materials in the shade and putting into an extraction tank;
the concrete operation of the steps is as follows: drying the raw materials in the shade, air drying until the water content is less than 10%, chopping the dried raw materials in the shade to keep the size of the leaves at 2-3cm, and putting the chopped raw materials into an extraction tank;
(2) direct steam: opening a straight-through steam valve of the extraction tank, introducing steam into the extraction tank, adjusting the steam pressure, and controlling the straight-through heating time and the tank body extraction temperature;
the steam pressure regulation comprises a first steam pressure regulation and a second steam pressure regulation, in the step (2), a straight-through steam valve of the extraction tank is opened, after steam is introduced into the extraction tank, the steam pressure is regulated for the first time, and after an oil-water mixture comes out, the steam pressure is regulated for the second time, wherein the steam pressure for the second steam pressure regulation is smaller than the steam pressure for the first steam pressure regulation, the first steam pressure regulation is used for evaporating the oil-water mixture in the ginger raw material, the quality of the extracted volatile oil is better, the second steam pressure regulation can fully evaporate the raw material, the product yield is improved, and the content of the volatile oil reaches 0.7%;
preferably, the steam pressure of the regulated steam pressure in the step (2) is 0.02-0.03MPa, the straight-through heating time is 1-2h, and the tank body extraction temperature is 90-100 ℃;
(3) separation: and condensing the oil-water mixture steamed by the steam, and separating in an oil-water separator to collect an oil layer.
9. A preparation method of a traditional Chinese medicine composition with curative effect on new coronavirus is characterized by comprising the following steps: accurately weighing radix Isatidis, cimicifugae rhizoma, Coptidis rhizoma, pulverizing, mixing with radix Angelicae Dahuricae oil, flos Magnoliae oil, cortex Magnolia officinalis oil, pericarpium Citri Tangerinae oil, radix Isatidis, and oleum herba Pogostemonis, or fructus forsythiae oil, lignum Santali albi oil, Notopterygii rhizoma oil and folium Artemisiae Argyi oil, mixing at a certain weight ratio, and making into corresponding preparations in the form of dripping pill, injection, unguent, mixture, gel, tablet, granule, pellet, aerosol, emulsion, microsphere, nanosphere, oral liquid, suspension or suppository.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107663475A (en) * | 2017-09-28 | 2018-02-06 | 江永百润福天然植物科技发展有限公司 | A kind of preparation method and ginger essential oil that ginger essential oil is extracted from ginger |
| CN111569010A (en) * | 2020-05-06 | 2020-08-25 | 石家庄市第五医院 | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating neocoronary pneumonia |
| CN112205430A (en) * | 2020-09-07 | 2021-01-12 | 恩民医药科技有限公司 | Traditional Chinese medicine extract composition and preparation method and application thereof |
| CN113279146A (en) * | 2020-09-30 | 2021-08-20 | 石家庄以岭药业股份有限公司 | Preparation process and application of spunbonded non-woven fabric containing honeysuckle antipyretic extract |
| CN113768984A (en) * | 2021-09-13 | 2021-12-10 | 澳门科技大学 | Traditional Chinese medicine composition and preparation method and application thereof |
-
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107663475A (en) * | 2017-09-28 | 2018-02-06 | 江永百润福天然植物科技发展有限公司 | A kind of preparation method and ginger essential oil that ginger essential oil is extracted from ginger |
| CN111569010A (en) * | 2020-05-06 | 2020-08-25 | 石家庄市第五医院 | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating neocoronary pneumonia |
| CN112205430A (en) * | 2020-09-07 | 2021-01-12 | 恩民医药科技有限公司 | Traditional Chinese medicine extract composition and preparation method and application thereof |
| CN113279146A (en) * | 2020-09-30 | 2021-08-20 | 石家庄以岭药业股份有限公司 | Preparation process and application of spunbonded non-woven fabric containing honeysuckle antipyretic extract |
| CN113768984A (en) * | 2021-09-13 | 2021-12-10 | 澳门科技大学 | Traditional Chinese medicine composition and preparation method and application thereof |
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