CN1064247C - Chinese drug for treating chronic bronchitis and its preparing process - Google Patents
Chinese drug for treating chronic bronchitis and its preparing process Download PDFInfo
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- CN1064247C CN1064247C CN96113159A CN96113159A CN1064247C CN 1064247 C CN1064247 C CN 1064247C CN 96113159 A CN96113159 A CN 96113159A CN 96113159 A CN96113159 A CN 96113159A CN 1064247 C CN1064247 C CN 1064247C
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- extractum
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- ethanol
- bulbus fritillariae
- chronic bronchitis
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Abstract
The present invention relates to a traditional Chinese medicine for treating chronic bronchitis, and a preparation method thereof. Ten kinds of traditional Chinese medicines comprising thunberg fritillary bulb, honeysuckle, etc., are proportionally mixed; some of thunberg fritillary bulb and squeezed bitter apricot kernels are extracted into an extract A by ethanol refluxing; hemlock parsley and radix peucedani are made into an extracting solution; residual herb residues and six kinds of traditional Chinese medicines comprising lonicera, etc., are decocted by adding water to obtain filtrate concentrated into an extract E; the extract A is mixed with the extract E, and is proportionally mixed with the residual thunberg fritillary bulb, sucrose and starch; the mixtures are pelletized, dried, bagged and made into finished products. The total effective rate is 96.00% and the obvious effective rate is 79.7%. The traditional Chinese medicine has the advantages of no toxic or side effects and stable performances, simultaneously has the functions of improving symptoms comprising cough, asthma, expectoration, etc., and is suitable for treating chronic bronchitis.
Description
The present invention relates to a kind of Chinese medicine and method for making thereof for the treatment of chronic bronchitis.
Chronic bronchitis is one of common high morbidity in the Northeast, it shows effect repeatedly, usually become the main reason of chronic obstructive emphysema and chronic pulmonary heart disease and people ' s health in serious threat, therefore ancient Chinese medicine doctor is all at the active drug of chronic bronchitis that seeks treatment, acute attack stage safe and effective medicine that particularly should disease.
The Chinese medicine that the purpose of this invention is to provide a kind of eutherapeutic treatment chronic bronchitis, its stable curative effect, and without any side effects.
Goal of the invention of the present invention also is to provide a kind of extraction ratio height, and can better guarantee the Chinese medicine and the method for making of the treatment chronic bronchitis of the property of medicine.
Goal of the invention of the present invention is achieved in that
The present invention selects medicine by following prescription:
Bulbus Fritillariae Thunbergii 3000-3700g Flos Lonicerae 1800-2200g
Radix Peucedani 1800-2200g Cortex Mori 1500-1850g
Semen Armeniacae Amarum 1500-1850g Radix Platycodonis 900-1100g
Rhizoma Belamcandae 900-1100g Herba Ephedrae 600-750g
Rhizoma Chuanxiong 150-200g Radix Glycyrrhizae 150-200g
The method for making of the Chinese medicine of treatment chronic bronchitis of the present invention is:
A gets the raw materials ready according to the composition of raw materials that claim 1 provides, and the Semen Armeniacae Amarum after the oil removing is packed in the extraction pot with a part of Bulbus Fritillariae Thunbergii after the fragmentation and squeezing, with 95% alcohol reflux three times, filter, three filtrates are merged, reclaim ethanol, concentrated filtrate is 1.30 extractum A to relative density;
B gets Rhizoma Chuanxiong and Radix Peucedani decoction pieces, puts in the reflux, extract, jar, adds 3 times of amount 95% alcohol reflux 3 hours, filters, and gets ethanol extract B and medicinal residues C;
C places extraction pot to decoct with water respectively three times medicinal residues C and Flos Lonicerae, Cortex Mori, Radix Platycodonis, Herba Ephedrae, Radix Glycyrrhizae, Rhizoma Belamcandae, and collecting decoction, filtration get filtrate D;
It is 1.15 that d is concentrated into proportion with filtrate D, puts cold back and stirs and add triplication 95% ethanol down, places to filter, and 60% ethanol stirs precipitate, filters, and merging filtrate and washing liquid, concentrate decompression recycling ethanol, relative density is 1.30 extractum E;
E gets extractum F with extractum A and extractum E mix homogeneously;
F becomes fine powder with remainder Bulbus Fritillariae Thunbergii powder, and by Bulbus Fritillariae Thunbergii: extractum F: starch: cane sugar powder is 1: 1: 0.5: 2 mixed is even;
G makes granule with an amount of ethanol extract B with the mixture of Bulbus Fritillariae Thunbergii extractum F and starch, sucrose, treats that granule will remain ethanol extract B after dried slightly and be sprayed on the granule, is mixed, and carries out cold drying behind the covered and enclosed again, and the granulate packing promptly.
The present invention is the anxious medicine of sending out the phase of treatment chronic bronchitis.The acute episode of chronic bronchitis phase is main pathology link with deficiency syndrome mingling with excess syndrome, and insufficiency of QI of the lung and kidney is it, and strongly fragrant in the expectorant heat is its mark, the principle of this photograph symptomatic treatment in acute condition, and when with clearing away lung-heat to relieve cough, resolving phlegm and relieving asthma is the main rule of treatment.The present invention is monarch with Flos Lonicerae, Bulbus Fritillariae Thunbergii clearing heat, eliminating phlegm, relieving cough, and Semen Armeniacae Amarum, Radix Peucedani, Cortex Mori, Rhizoma Belamcandae are minister, and auxiliary monarch drug strengthens to be dredged a surname's the strongly fragrant of sharp lung key and hold back, unobstructed lung qi and receive the merit of relieving cough and resolving phlegm.The closing that assistant is opened lung qi with Rhizoma Chuanxiong, Herba Ephedrae, Radix Platycodonis, medicine carrying power and up makes with the invigorating middle warmer of Radix Glycyrrhizae QI invigorating, and coordinating the actions of various ingredients in a prescription is played the effect of clearing away lung-heat to relieve cough, resolving phlegm and relieving asthma altogether.Medicine of the present invention carries out acute and chronic evidence avirulence through the Jilin Province academy of traditional Chinese medicine, stability observing through 1 year shows its character, identification, moisture content, granularity and assay, health examination is every to have no significant change, and the stable performance of this medicine is described.The first clinical hospital, Changchun institute of traditional Chinese medicine, Changchun central hospital, Jilin Renmin Hospital, Attached Hospital, Changchun Chinese Medicinal College are from April, 1994 to 1994 year clinical observation acute episode of chronic bronchitis phases 400 in July example through the Norman Bethune Medical University, wherein use Drug therapy 300 examples of the present invention, the result shows, the total obvious effective rate of the present invention is 79.7%, and total effective rate is 96.00%.Show through clinical observation, the present invention coughs in improvement, breathes heavily, expectorant, in the time of primary symptoms such as wheezing sound, rale, thirsty, pharyngalgia, heating and sign, chest x-ray sign has clear improvement, reduce the body temperature and the leukocyte that raise, improve pulmonary function, reduce partial pressure of carbon dioxide, rising partial pressure of oxygen and the effect that expectorant cultivation the moon is changeed, each is organized data and all is better than matched group.The present invention does not have toxic and side effects such as liver, renal function injury, really for the anxious active drug of sending out phase heat-phlegm, dyspnea of heat type sign of treatment chronic bronchitis, fabulous popularization and using value is arranged.
Method of the present invention is effectively come out required extract drugs, and has fully guaranteed curative effect of the present invention.Bulbus Fritillariae Thunbergii is monarch drug among the present invention, and its important active ingredient is the Bulbus Fritillariae Uninbracteatae alkaloid, and the present invention's extracting method makes in the extractum active drug content the highest.Bulbus Fritillariae Thunbergii contains a large amount of starch, high mealiness in addition, it is fabulous way that Bulbus Fritillariae Thunbergii is used as medicine with fine powder, both can reduce supplementary product consumption, can improve the electuary quality again, so adopt a part of Bulbus Fritillariae Thunbergii to extract the flow process that the direct powder of another part Bulbus Fritillariae Thunbergii becomes fine powder to be used as medicine in the technology.Volatile oil is all arranged in Radix Peucedani and the Rhizoma Chuanxiong, adopt ethanol extraction, medicinal residues close with all the other medicines and fry in shallow oil, and gained extractum is granulated with Radix Peucedani, Rhizoma Chuanxiong ethanol extract after the precipitate with ethanol removal of impurity, and cold drying can keep the unlikely loss of volatile component.Because the long-time decocting meeting of amygdalin decomposes is so use ethanol extraction after selecting oil removing for use.Medical materials such as Flos Lonicerae, Cortex Mori, Radix Platycodonis, Rhizoma Belamcandae, Radix Glycyrrhizae mainly contain glycoside, not only water soluble but also be dissolved in alcohol of compositions such as flavonoid glycoside, Saponin, triterpenoid saponin wherein, ephedrine in the Herba Ephedrae many forms with salt in plant exist, also water soluble and alcohol, therefore the medicinal residues after this Six-element medicine and Rhizoma Chuanxiong, decursinol extract adopt decoction alcohol precipitation method to extract, can improve active ingredient, improve the ratio of live part, reduce patient's dose.
The invention will be further described below in conjunction with embodiment.
Get the raw materials ready by following prescription:
Bulbus Fritillariae Thunbergii 3500g Flos Lonicerae 2100g
Radix Peucedani 2100g Cortex Mori 1700g
Semen Armeniacae Amarum 1700g Radix Platycodonis 1050g
Rhizoma Belamcandae 990g Herba Ephedrae 690g
Rhizoma Chuanxiong 175g Radix Glycyrrhizae 175g
The method for making of the Chinese medicine of treatment chronic bronchitis of the present invention is:
Bulbus Fritillariae Thunbergii 1650g and Semen Armeniacae Amarum squeezing oil removing after of the raw material gram number that a is provided according to the above-mentioned raw materials prescription after with fragmentation packed in the extraction pot, use 95% alcohol reflux 2 hours, 1.5 hours, 1.5 hours of 5 times, 3 times, 3 times amounts successively, filter, three filtrates are merged, reclaim ethanol, concentrated filtrate to relative density is 1.30 extractum A, and temperature is 80 ℃;
B gets Rhizoma Chuanxiong and Radix Peucedani decoction pieces, puts in the reflux, extract, jar, adds 3 times of amount 95% alcohol reflux 3 hours, filters, and gets ethanol extract B and medicinal residues C;
C places extraction pot with medicinal residues C and Flos Lonicerae, Cortex Mori, Radix Platycodonis, Herba Ephedrae, Radix Glycyrrhizae, Rhizoma Belamcandae, adds 10 times, 7 times, 5 times water gagings successively, decocts respectively 2 hours, 1.5 hours, 1.5 hours, and collecting decoction, filtration get filtrate D;
It is 1.15 that d is concentrated into proportion with filtrate D, and temperature is 50 ℃, puts cold back and stirs adding triplication 95% ethanol down, places to filter, stir precipitate with 60% ethanol, filter merging filtrate and washing liquid, decompression recycling ethanol, concentrate, relative density is 1.30 extractum E, temperature is 80 ℃;
E gets extractum F with extractum A and extractum E mix homogeneously;
F becomes fine powder with remainder Bulbus Fritillariae Thunbergii powder, and by Bulbus Fritillariae Thunbergii: stain cream F: starch: cane sugar powder is 1: 1: 0.5: 2 mixed is even;
G makes granule with an amount of ethanol extract B with the mixture that Bulbus Fritillariae Thunbergii floods cream F and starch, sucrose, treats that granule will remain ethanol extract B after dried slightly and be sprayed on the granule, be mixed, and covered and enclosed 2 hours, cold drying, the granulate packing, every 7g gets final product for one bag.
Claims (2)
1, a kind of Chinese medicine for the treatment of chronic bronchitis, it is characterized in that: the composition of raw materials of this medicine is:
Bulbus Fritillariae Thunbergii 3000-3700g Flos Lonicerae 1800-2200g
Radix Peucedani 1800-2200g Cortex Mori 1500-1850g
Semen Armeniacae Amarum 1500-1850g Radix Platycodonis 900-1100g
Rhizoma Belamcandae 900-1100g Herba Ephedrae 600-750g
Rhizoma Chuanxiong 150-200g Radix Glycyrrhizae 150-200g
2, a kind of method for making of Chinese medicine of treatment chronic bronchitis as claimed in claim 1 is characterized in that:
A gets the raw materials ready according to the composition of raw materials that claim 1 provides, and the Semen Armeniacae Amarum after the oil removing is packed in the extraction pot with a part of Bulbus Fritillariae Thunbergii after the fragmentation and squeezing, with 95% alcohol reflux three times, filter, three filtrates are merged, reclaim ethanol, concentrated filtrate is 1.30 extractum A to relative density;
B gets Rhizoma Chuanxiong and Radix Peucedani decoction pieces, puts in the reflux, extract, jar, adds 3 times of amount 95% alcohol reflux 3 hours, filters, and gets ethanol extract B and medicinal residues C;
C places extraction pot to decoct with water respectively three times medicinal residues C and Flos Lonicerae, Cortex Mori, Radix Platycodonis, Herba Ephedrae, Radix Glycyrrhizae, Rhizoma Belamcandae, and collecting decoction, filtration get filtrate D;
It is 1.15 that d is concentrated into proportion with filtrate D, puts cold back and stirs and add triplication 95% ethanol down, places to filter, and 60% ethanol stirs precipitate, filters, and merging filtrate and washing liquid, concentrate decompression recycling ethanol, relative density is 1.30 extractum E;
E gets extractum F with extractum A and extractum E mix homogeneously;
F becomes fine powder with remainder Bulbus Fritillariae Thunbergii powder, and by Bulbus Fritillariae Thunbergii: stain cream F: starch: cane sugar powder is 1: 1: 0.5: 2 mixed is even;
G makes granule with an amount of ethanol extract B with the mixture of Bulbus Fritillariae Thunbergii extractum F and starch, sucrose, treats that granule will remain ethanol extract B after dried slightly and be sprayed on the granule, is mixed, and carries out cold drying behind the covered and enclosed again, and the granulate packing promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96113159A CN1064247C (en) | 1996-10-17 | 1996-10-17 | Chinese drug for treating chronic bronchitis and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96113159A CN1064247C (en) | 1996-10-17 | 1996-10-17 | Chinese drug for treating chronic bronchitis and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1167625A CN1167625A (en) | 1997-12-17 |
| CN1064247C true CN1064247C (en) | 2001-04-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96113159A Expired - Fee Related CN1064247C (en) | 1996-10-17 | 1996-10-17 | Chinese drug for treating chronic bronchitis and its preparing process |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049424B (en) * | 2006-04-03 | 2012-01-18 | 湖南中达骛马制药有限责任公司 | Medication for treating infection in respiratory system |
| CN102526606A (en) * | 2010-12-16 | 2012-07-04 | 天津中敖生物科技有限公司 | Traditional Chinese medicine composition with cough-relieving and phlegm-resolving function and preparation method thereof |
| CN102499977B (en) * | 2011-11-28 | 2013-07-17 | 薛洁 | Traditional Chinese medicine preparation for treating children bronchopneumonia |
| CN104225564A (en) * | 2014-10-06 | 2014-12-24 | 李先强 | Traditional Chinese medicinal pill for treating chronic cough induced tracheitis |
| CN108743856A (en) * | 2018-08-29 | 2018-11-06 | 贵州盘州阿卡迪亚医疗管理有限公司 | A kind of Chinese medicine composition that treating bronchitis and its application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1018190B (en) * | 1988-05-19 | 1992-09-09 | 巴马格股份公司 | Spinning apparatus |
| CN1018348B (en) * | 1990-03-16 | 1992-09-23 | 李本茂 | Oxygen lance method for punching and cutting concrete and the apparatus thereof |
-
1996
- 1996-10-17 CN CN96113159A patent/CN1064247C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1018190B (en) * | 1988-05-19 | 1992-09-09 | 巴马格股份公司 | Spinning apparatus |
| CN1018348B (en) * | 1990-03-16 | 1992-09-23 | 李本茂 | Oxygen lance method for punching and cutting concrete and the apparatus thereof |
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| Publication number | Publication date |
|---|---|
| CN1167625A (en) | 1997-12-17 |
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