KR20080105825A - Herb composition useful for arthritis treatment or prevention and preparation thereof - Google Patents

Abstract

A herb medicine composition for treating and preventing arthritis, and a method for preparing the herb medicine composition are provided to reduce side effect and to improve the convenience and safety of medicine taking. A herb medicine composition for treating and preventing arthritis is prepared by extracting 20 wt% of Eucommiae cortex, 20 wt% of Angelica gigas Nakai, 15 wt% of Achyrantis Radix, 15 wt% of Atractyodis Rhizoma, 10 wt% of Clematidis Radis, 5 wt% of Commiphora myrrha ENGL., 5 wt% of Kalopanax ricinifolium, 5 wt% of Angelica pubescens MAXIM. and 5 wt% of the bark of a willow, and fermenting the extracted one.

Description

Herb composition useful for arthritis treatment or prevention and preparation

The present invention relates to a method for extracting and fermenting an active ingredient from a complex herbal medicine showing an excellent effect on preventing and treating arthritis, a herbal composition containing the extract, and a method for preventing and treating arthritis using the same. More specifically, nine herbal medicines such as hyssop, creation, donkey, tofu, gastrointestinal tract, myrrh, and poisonous extract are mixed at an appropriate ratio, extracted with hot water or alcoholic aqueous solution, filtered, fermented with Acetobacter fungus, or yeast, and concentrated. It relates to a pharmaceutical composition for treating arthritis having a joint protective effect as a composition of the obtained fermentation product and a method for producing the same.

In general, arthritis is largely divided into osteoarthritis (Osteoarthritis) and rheumatoid arthritis, arthritis and joint inflammation-related diseases occur in various forms.

Arthritis is a chronic polyarthritis characterized by inflammatory changes, especially in the synovial membrane of the lining of the articular capsule. It is a chronically advanced disease that causes swelling and pain in the joints of the whole body and, in severe cases, can cause disability. Arthritis diseases, such as rheumatoid arthritis, are also progressive and develop joint disorders such as deformation and joint instability, often causing physical disability with severe pain due to lack of effective treatment and continued exacerbation.

The direct cause of arthritis is not clear yet, and research on this is ongoing. Effective prevention of arthritis such as rheumatoid arthritis has not been known until now. There are many points left.

Traditionally, these arthritis treatments include steroid crabs, such as cortisone and other corticosteroids, nonsteroidal anti-inflammatory agents, such as aspirin, pyroxam, and indomethacin, gold agonists, such as orothioactive acid, chloroquinones, and D-penny Chemotherapy has been treated with various agents including antirheumatic agents such as silamine, gout inhibitors such as colchicine, and immunosuppressants such as cyclophosphamide, azathioprine, methotrexate, and levamisol.

The treatments mentioned above are not a fundamental treatment, and steroid hormones have been widely used as arthritis treatments, but as the side effects become obvious, their use has become difficult.

In addition, since arthritis, especially chronic rheumatoid arthritis, causes severe pain in patients, it is necessary to take anti-inflammatory drugs, etc. Until now, aspirin and betazoline drugs have been used for a long time to alleviate such pain or to remove joint swelling. Has been used. However, aspirin and the like have a fatal effect on the stomach, so it is difficult to continue taking the amount needed to treat arthritis.

Existing chemotherapeutic agents have drawbacks such as side effects that hinder the long-term use of the drugs, lack of anti-inflammatory effects, and lack of efficacy against arthritis that has already occurred, and indomethacin, which is currently effective in treating arthritis. And furphenic acid and various non-steroidal anti-inflammatory agents are used in preparation.

Thus, there is a need for solutions to these problems and the development of arthritis medications that have symptomatic effects on acute inflammatory symptoms and pain, and most of the arthritis medications currently in use are somewhat different, but all have some side effects. In order to treat rheumatoid arthritis, especially since it is necessary to take a long time, it is very important to develop a medicine with less side effects.

In addition, some of the medicine may be administered by intravenous injection or intraperitoneal injection, in which case it is not only cumbersome but repeated intravenous injection may cause allergy, shock as well as hygiene problems. Therefore, there is a need for a simple and safe treatment.

Accordingly, an object of the present invention is to provide a herbal composition for treating arthritis and a method of preparing the same, which have fewer side effects and are easy to take.

In the study of the present inventors to achieve the above object, to maximize the characteristics and efficacy of each of the nine herbal medicines, such as worms, hyssop, Angelica, creation, gastric, myrrh, poisonous activity and to treat arthritis, in particular, through the fermentation process It maximizes cartilage protection by maximizing absorption of cartilage, and it can be used as a general food because it has the least toxicity among various kinds of herbal medicines based on the principle of herbal medicine, hard muscle bone, blood circulation and tissue regeneration. Those who have almost no side effects are also selected, and through the fermentation process of the herbal medicine raw materials through a test experiment for the treatment of arthritis to select satisfactory herbal medicine that is effective in the treatment and prevention of arthritis to complete the present invention through the fermentation method.

According to the present invention 20% by weight bark bark, 20% by weight of Angelica root, 15% by weight of root, 15% by weight of root generation, 15% by weight of roots, 5% by weight of myrrh root, 5% by weight of myrrh stem, 5% by weight of oak stem, poison 5 Provided is a herbal composition for treating and preventing arthritis, which is simultaneously extracted or 5% by weight of willow bark is extracted or fermented, respectively.

In addition, according to the present invention, 20% by weight of bark larvae, 20% by weight of Angelica root, 15% by weight of roots, 15% by weight of rhizome stems, 10% by weight of lichen roots, 5% by weight of myrrh, 5% by weight of the bark of the oak stem, poisonous Provided is a method for producing a herbal composition for the treatment and prevention of arthritis, including a herbal extract step of simultaneously extracting 5% by weight and 5% by weight of willow bark, or by separately extracting and fermenting the obtained extract.

In addition, according to the present invention there is provided a method for producing a herbal composition further comprising the step of concentrating the extract fermented in the fermentation step.

Hereinafter, the present invention will be described in detail.

Nine herbal medicines, including the main components used in the present invention, such as tofu, dew, donkey, creation, gastric, myrrh, poison, etc., are generally well known in oriental medicine and have almost no side effects such as toxicity through fermentation. .

The characteristics and specific actions of each of these herbs are as follows.

It refers to dried root of Angelica gigas NAKAI of Dong quai or Umbelliferae. In China, dried root of Angelica sinensis DIELS is used. In Japan, Angelica acutiloba is used. KITAGAWA) roots have been used to dry. Angelica is effective in the treatment of women's postpartum disease, anemia, headache, etc. as a summary of blood clots, as a supplement to the effects and heuristic of blood and blood. (Commercial Plant Book, Jong-Hee Park, Jung-Kyu Lee, Shin Il-Sang, pp409- 411, 2000; Chinese Herbal Medicine, Health Newspaper, pp684-686, 1998).

Hardy Rubber Tree is a deciduous broad-leaved (Eucommia ulmoides) plant of the dicotyledonous rose family, which is a plant native to China. Promotes bone formation while strengthening. The bark is used as a medicine and tonic, strengthens the cerebrum, and manages lung and knee ailments and groin. In the private sector, the leaves are used for neuralgia and hypertension, and they are also taken as tea. (Chang Chang-min et al., Primary Herbal Medicine Book, Academic Book, 190p, 2001; Modern Pharmacy, Hakchangsa. 1991; Ahn Deokgyun, Primary Korean Color Book. , Korean Color Book of Korean Plants and Teachers, 1996; Lee Woo-Chul, Color Book of Korean Standard Plants, Academy Books 1996; Lee Chang-bok, Korean Flower Books, Hyangmunsa, 1979; Jeong Tae-hyun, Korean Flower Books, Shinjisa 1958; Notes, Korean Medical Index, 489p, 1998; Ahn Deok-gyun, Korea Herbal Book, Kyohaksa, 670p, 2000; Hong Won-sik, Ingredients and Utilization of Medicinal Herbs, Ilwol Seokje, 177p, 1999).

Japanese Achyranthes refers to the roots of Achyranthes japonica Nakai or Acyranthes bidentata Blume (牛膝) in Korea, and in Japan, Acyranthes bidentata Blume (牛膝) and hairy knee (털) in Japan. Achyranthes fauriei H. Lev. & Vaniot). China recognizes only Acyranthes bidentata Blume. In oriental medicine and private medicine, it is used for medicines such as blood, bowel, arthritis, gout, diuresis, canine pain, pain, and blood. It is effective for gonorrhea, hematuria, abolition of menstruation, abdominal pain due to postpartum blood, pain in the knee, and bruises. Alcohol and water extracts from the roots have pronounced uterine contractions in animal experiments. Its action is particularly intense in the late conception and in the uterus. (Hong Won-sik, Ingredients and Utilization of Herbs, Ilwol Seokgak, 222p, 1999; Lee Young-no, Korea Book of Plants, Kyohaksa, 434p, 1998; Doosan World Daebaekwa encyber; Studies on the range of animals and plants that can be used as raw materials for processed foods, Korea Food Industry Korean Food Research Institute, 323p, 1994; Kim, Tae-Jung, Wildflowers, Kyohaksa, 336p, 2001).

It is a perennial plant of Atractylodes japonica, a dicotyledon of the Atractylodes japonica, and it is effective for sweating, diuresis, analgesia, dryness, etc. World Encyclopaedia encyber; Park Jong-Hee et al., Commercial Medicinal Plants Book, Shinil Corporation, 208p, 2000).

Clematidis Radix is a vine perennial herb of Clematis mandshurica var. Koreana, which removes customs and soothes pains. It is used to relieve pain and muscle paralysis of legs, and also when pain persists due to bruises. (Hyung-Joon Ji, Herbal Medicine (Medicinal Herbs) Standard Collection), Korea Medical Index, 290p, 1998; Hong Won-sik, Ingredients and Utilization of Herbs, Ilwol Seokgak, 281p, 1999; http://www.tradimed.co.kr/htrad/drug.asp; HK Do, Shin Rhong Bon Cho Kyung, 452).

Myrrh (沒 藥, myrrh) is also called myrrha. It is also called a lotus flower to distinguish it from the hay flock used in dyes. It is a natural rubber resin obtained by wounding bark such as C. myrrha or C. abyssinica, an olive and plant native to Africa and Arabia.血) to treat dysmenorrhea, amenorrhea, postpartum abdominal pain, abdominal pain due to congestion. The bruise causes the blood to linger and relieve the symptoms of persistent pain. It is widely used for quadriplegia pain and arthritis due to the custom. Treats skin ulcers that do not heal for a long time. (Andeokgyun, Korea Herbal Painting, Kyohaksa, 568p, 2000; Kim, Changmin et al. 2, Primary Color Herbal Medicine, Academy Book, 307p, 2001; A Study, Korea Food Research Institute, Korea Food Research Institute, 144p, 1994; co-authored by Jang Sang-moon et al. Medicinal Herbal Botanicals, Academic Publishing, 523p, 1996; ).

The moss (Caster Aralia) is a deciduous tree of the dicotyledon of the Kalopanax pictus. Peel off the outer skin of the stem in spring and summer, peel off the inner skin and dry it in the sun to use as a medicinal herb. In Chinese medicine, bark, root bark is used as medicine for expectoration, pain, etc. In civilian use, peels and leaves are used for skin diseases, ulcers, and infectious wounds. It was used as a medicine for treating quadriplegia and lesions. (Potonic Taxonomic Study of Korean Elmaceae, Journal of Plant Classification, 19: 103-121, 1989,; Color Book of Korean Standard Plants, Academy Book, 1996; Color Book of Korean Plants, Kyohaksa, 1996 ; Primary Color Book of Korea, Teaching History, 1998; Korean Tree Culture, Book of Art, 1996; Primary Color Book, Academy Book, 197, 2001).

Medicinal herbs (Korea) made from the roots of the poisonous leaf (Aralia continentalis Kitagawa). China wears Angelica pubescens Maxim.f.biserrata Shan et Yuan (Japan). The root stem of Aralia cordata Thunb.) Is used as a poison, and is used for myalgia, arthritis, low back pain, pain and weakness of the knee and lower limb caused by abundant humidity, and itching and skin itching. It is widely used in fever, chills, headache, limb pain due to externality, and it treats boils due to acidic effect. (Kim Chang-min, primary color map, 34p, academy book, 2001; 33p, 2000; Kim, Tae-Jung, Korean Herb, Easily Finding, Hyeonamsa, 100p, 2001; Koh Jun-jun, Medicinal Herbs (Medicinal Herbs) Standard, Korea Medical Index, 185p, 1998).

Willow is a deciduous tree of the salix koreensis Anderss. It has a good effect on mild symptoms such as cold body pain and fever caused by headaches and inflammation of acute rheumatism and mild symptoms (Lee Young-no, Color Book of Korea Botany, Kyohaksa, 51p, 1998; Doosan World White Encyclopedia; http://www.herbnhealth.co.kr/herbindex/willow.html).

As mentioned above, each of these herbal medicines is composed of herbal medicines commonly used in various wounds or boils, pancreatitis and anemia, headache, cold and neuralgia, arthritis and bruise, and each herbal medicine has unique pharmacological action and main effect. It has However, until now, each of these herbal medicines has been studied only for its efficacy as a one-way herbal medicine and for the method of separating and preparing the active ingredients, and in some cases, some herbal medicines have been mixed and used to obtain a therapeutic effect on arthritis. The efficacy was not scientifically proven and the effect was insignificant. Moreover, the focus was not on protecting and regenerating the cartilage and tissue of the joints, which are the core of arthritis treatment.

The herbal medicines used in the present invention are the bark of the larvae, the root of the Angelica, the root of the dew, the rhizome of the creation, the root of the lichen, the myrrh, the bark of the oak stem, the poisonous tree and the willow bark.

The ratio of the herbal medicine used in the present invention is 20% by weight of dried medicinal herb bark, 20% by weight of Angelica root, 20% by weight of root, 15% by weight of root, 15% by weight of rhizome, 10% by weight of lichen root, 5% by weight of myrrh, 5% by weight of the bark of the oak stem, 5% by weight of poison and 5% by weight of the bark of willow. The above weight ratios are based on dried herbal medicines with a water content of 15% or less.

 Preferably, the herbal medicines are 5 to 10 times, more preferably 10 to 15 times volume / weight of distilled water, lower alcohols such as ethanol, or a mixed solvent thereof, preferably distilled water alone or a mixed solvent of 30 to 50% water and ethanol. Was added and cooled to 12 hours to 24 hours, preferably 24 hours to 36 hours at 15 ° C. or lower to room temperature, and then 8 to 12 hours at 90 to 100 ° C., preferably 12 to 24 hours at 80 to 90 ° C. Extraction by reduced pressure extraction yields a complex herbal extract available in a polar solvent.

In addition, since the fermentation conditions of the present invention are less than 20 ℃ and 50 ℃ or more fermentation efficiency, 15 to 20 days is preferable at 25 ℃ to 40 ℃.

After filtering the fermentation broth obtained from the fermentation step, it can be obtained from the manufacturing process X obtained by concentration under reduced pressure at 60 to 80 ℃.

In the present invention, the herbal medicines may be mixed and extracted at the same time or may be separately extracted and mixed.

The herbal composition of the present invention may further include conventionally used excipients, disintegrants, sweeteners, lubricants, flavoring agents, etc., tablets, capsules, granules, suspensions, emulsifiers, syrups, solutions Or in dosage unit or multiple dose pharmaceutical formulations, such as parenteral formulations.

In the herbal composition of the present invention, the dosage level for a particular patient may vary depending on the weight, age, sex, health condition, diet, time of administration, administration method, excretion rate, severity of disease, and the like of the patient.

In the present invention, arthritis means all kinds of arthritis, and among them, especially means bruising arthritis, rheumatoid arthritis, degenerative arthritis, gouty arthritis, purulent arthritis and tuberculosis arthritis that are pulp by bacteria.

Other compositions of the present invention are also effective in autoimmune diseases such as systemic lupus erythematosus and amyloidosis.

In the preparation of the herbal composition of the present invention, in the fermentation step, the herbal extract may be fermented using rice and koji or alcohol and acetic acid bacteria, etc., and the obtained fermentation broth may be concentrated under reduced pressure if desired.

In another aspect, the present invention includes a concentrated extract extracting a compound herbal, such as tofu, pull, creation, dew, gas, etc. with a lower alcohol having 1 to 4 carbon atoms to remove the residual solvent, and can also be applied to the extract prepared so fermentation process have.

The types of koji (koji) raw materials are wheat and rice coated with wheat flour, and mung bean, glutinous rice and barley are also used. Yeast sources include air, dogweed, barley straw, rice straw, mulberry, wormwood, resident, lotus, young leaves of pine needles and pine needles. Non-raw stocks include roasted, steamed, steamed, and wheat flour, and the raw material has a particle size from 12% to fine powder. Types of raw materials include mulberry leaves, mugwort, lactation decoction, peach seed powder, apricot seed powder, melon powder and the like, which are prepared by treating coenzyme. Coenzyme enhances glycation by cultivating bacteria such as Rhyzopus, Usami and Oryzae, which are the main strains of conventional Nuruk, and simultaneously pursues the complex taste and saccharification of natural Nuruk.

The following examples are merely to illustrate the invention, but the content of the invention is not limited to the examples and experimental examples.

Example 1

To the herbal medicines purchased at Gyeongdong Market, namely tofu, 40g each of mulberry, 40g of dew, 30g of each generation, 10g of lichen, 10g of myrrh, myrrh, oak tree, poisonous tree, 10g of each of willow tree, add 2L of distilled water and maintain 90-95 ℃. The filtrate was separated by filtration under reduced pressure and the filtrate was separated. The filtrate was collected and cooled twice in the same manner. 5% of fermented alcohol and 3% of Acetobacter aceti were added to the filtrate. After fermentation for 1 day, the mixture was filtered, the filtrate was heated up to 75-85 ° C, concentrated under reduced pressure, and the solvent was evaporated to obtain 87 g of a fluid extract having a solid content of 63%.

Example 2

A mixed solvent of distilled water and 1 liter of alcohol was added to the mixed herbal medicine of Example 1, and the filtrate was separated by filtration under reduced pressure for 8 hours, maintained at 90 to 95 ° C., and the filtrate was collected twice. Concentrated under reduced pressure at ℃ and evaporated to cool the alcohol, 5% fermented alcohol and acetic acid bacterium (Acetobacter aceti) was added to the filtrate and mixed well, fermented at 30-35 ℃ for 15 days, and filtered and the filtrate was 75-85 ℃ The mixture was heated up to, concentrated under reduced pressure, and the solvent was evaporated to obtain 94 g of a fluid extract having a solid content of 63%.

Example 3

2 liters of distilled water was added to the mixed herbal medicine of Example 1, and the filtrate was separated by filtration under reduced pressure for 8 hours, maintained at 90 to 95 ° C., and the filtrate was collected and cooled twice in the same manner. In addition, add koji rice 70 and yeast 0.2% purchased from traditional market, mix well, cover with air-clean cloth, ferment for 36 hours at 25 ℃, and invert once and grow yellow green spores. Was dried at 50-60 ° C. 10% dried grains were added to the extract, mixed well, fermented at 30-35 ° C. for 15 days, filtered and filtered. The filtrate was heated to 75-85 ° C., concentrated under reduced pressure, and the solvent was evaporated. Got.

Example 4

A mixed solvent of 1 liter of distilled water and 1 liter of alcohol was added to the mixed herbal medicine of Example 1, and the filtrate was separated by filtration under reduced pressure for 8 hours, maintained at 90 to 95 ° C., and the filtrate was collected and cooled twice in the same manner. Yeast purchased from traditional market 30: Add 70% of soybean rice and 0.2% of yeast, mix well, cover with airy clean cloth and ferment for 36 hours at 25 ℃. Dried at -60 ° C. 10% dried grains were added to the extract, mixed well, fermented at 30-35 ° C. for 15 days, filtered and filtered. The filtrate was heated to 75-85 ° C., concentrated under reduced pressure, and the solvent was evaporated. Thus, 91 g of liquid extract having a solid content of 91 g was extracted. Got.

The herbal composition of the present invention is effective in treating and preventing arthritis, and in particular, products such as fermentation thereof are more effective in treating arthritis, and thus, as an alternative to conventional chemotherapeutic treatments, can be used as a preventive and therapeutic agent for arthritis with excellent efficacy without side effects. It can be prepared by the X, liquid, pills, powder, tablets, granules, capsules and the like can be usefully used as health functional foods and medicines.

Claims (3)

20% by weight bark bark, 20% by weight of Angelica root, 15% by weight of root root, 15% by weight of rhizome root, 10% by weight of lichen root, 5% by weight of myrrh, 5% by weight of bark of oak stem, 5% by weight of poison and bud Herbal composition for the treatment and prevention of arthritis, characterized in that the fermented by simultaneously extracting or 5% by weight of the bark of each tree. 20% by weight bark bark, 20% by weight of Angelica root, 15% by weight of root root, 15% by weight of rhizome root, 10% by weight of lichen root, 5% by weight of myrrh, 5% by weight of bark of oak stem, 5% by weight of poison and bud A method of producing a herbal composition for treating and preventing arthritis, comprising extracting the herbal bark at the same time or extracting and mixing 5% by weight of bark at the same time. The method of claim 2, further comprising the step of concentrating the extract fermented in the fermentation step.