CN101214296A - Hypertension-treating medicine and preparation thereof - Google Patents

Abstract

The present invention relates to a Chinese patent medicine for curing hypertensive disease, including the components of salvia miltiorrhiza, Herba Cephalanoploris, herba gynostemae, cassia seed, ginkgo biloba, common selfheal, hawkthorn, honey and dogbane leaf. Herba Cephalanoploris and hawkthorn are cleaned and decontaminated, then milled and filtered after dipping in water, and the drug liquid is for standby; danshen, herba gynostemae, ginkgo biloba, common selfheal, dogbane leaf and cassia seed are cleaned and decontaminated, decocted for twice and filter; the filtrate mixed with the drug liquid and added with honey is decompressed and condensed to 1/3 of the original volume; the drug liquid is placed until the temperature decreases to less than 40 DEG C and then added with ethanol for 24-hour settlement; the supernatant is filtered so as to recover ethanol. pH value is adjusted to 5.5 to 6.5 and water is added to 10,000ml. After shaking, standing, filtering, filling and sterilizing, the Chinese patent medicine is obtained. According to clinical observation, the present invention has the effect of reducing hypertension and hyperlipemia, softening blood vessels, and seeking both temporary and permanent solutions.

Description

Hypertensive medicine of a kind of treatment and preparation method thereof

Technical field.

The present invention relates to a kind of medicine, be specifically related to hypertensive medicine of a kind of treatment and preparation method thereof.

Background technology

Hypertension is a kind of commonly encountered diseases frequently-occurring disease, the Chang Keyin rupture of blood vessel in brain and cause Hemorrhagic strokes or because of the supply heart coronary thrombosis cause serious consequences such as cardiac dysfunction, myocardial infarction, coronary heart disease, cerebral thrombosis.China's hypertension prevalence obviously rises, estimate according to relevant department, China more than 15 years old the hypertension number of patients reached more than 9,000 ten thousand, estimated also can increase more than 60% by 2010, according to present fashion trend investigation, the control form allows of no optimist, and China has become one of the most serious country of hypertension harm in the world.

Though the hypertensive method of treatment is a lot of at present, but because this disease pathogeny is comparatively complicated, great majority adopt medicine, massage, acupuncture-moxibustion, spirit etc. are carried out comprehensive therapy, blood vessel dilating when hypertension, to reduce the pressure of blood to blood vessel wall, though obtained curative effect preferably, but blood vessel be have chemical sproof, be expanded to a certain degree just not further expansion, so, the phenomenon that patient's depressor is eaten more and more has just appearred, though hypertensive complication has been played the better controlled effect, certain dependency is arranged, will rebound after discontinuing medication, take and make sclerosis of blood vessels for a long time, bring a lot of complication, have a variety ofly, certain curative effect is also all arranged in clinical use though be used for the treatment of hypertensive medicine at present, but all in various degree exist side effect big, curative effect is definite inadequately, can not treating both the principal and secondary aspects of a disease, also be unfavorable for fundamentally eliminating disease.

Summary of the invention

The objective of the invention is deficiency, a kind of hypertensive medicine of treatment that can reduce hypertension, hyperlipidemia, vessel softening, treating both the principal and secondary aspects of a disease is provided at the prior art problem.

Another goal of the invention of the present invention provides the preparation method of this medicine.

The present invention is a kind of, and to treat hypertensive medicine be the medicament of being made by the following materials based on weight medicine:

Radix Salviae Miltiorrhizae 10～20 Herba Cirsiis 15～25 Herb Gynostemmae Pentaphylli 5～10 Semen Cassiaes 5～10

Folium Ginkgo 10～20 Spica Prunellaes 5～10 Fructus Crataegis 5～15 Mel 3～6

Folium Apocyni Veneti 10～20.

Above-mentioned each component can be made said dosage form on any pharmaceutics, and as decoction, tablet, powder, capsule, electuary, oral liquid etc., the preferred dosage form of the present invention is an oral liquid.

Treat the preparation method of hypertensive medicine: a, Herba Cirsii, Fructus Crataegi are cleaned roguing, add 5 times of water gagings and soak, soak making beating filtration after 6 hours, medicinal liquid is standby; B, Radix Salviae Miltiorrhizae, Herb Gynostemmae Pentaphylli, Folium Ginkgo, Spica Prunellae, Folium Apocyni Veneti, Semen Cassiae are cleaned roguing, decoct secondary, each 1 hour, add 5 times of water gagings at every turn, filter, filtrate and the merging of above-mentioned filtrate add Mel, are evaporated to 1/3rd of original volume; C, placement when treating that fluid temperature is reduced to below 40 ℃, add 2 times of amounts, 95% ethanol sedimentation 24 hours, get supernatant and filter, and reclaim ethanol.Regulate pH value to 5.5～6.5, add water to 10000ml, shake up, leave standstill, filter, fill, sterilization is promptly.

In the prescription of the present invention: Radix Salviae Miltiorrhizae has function of promoting blood circulation to disperse blood clots, and platelet aggregation is had obvious inhibitory action, improves cerebral ischemia district blood flow, improve cerebral hypoxia, obviously improve the high viscous state of blood, reduce blood viscosity, the blood fat reducing peroxidization is eliminated oxygen-derived free radicals, reduces TXB ₂Discharge EDRF and PGI ₂Lax blood vessel, microcirculation improvement, renal blood flow increasing, protection renal tissue and function.Herba Cirsii has cooling blood for hemostasis, and removing toxicity for eliminating carbuncles is changed the silt effect of stimulating the menstrual flow, and treatment heat in blood, spitting of blood, hematuria, hot carbuncle toxin etc. are arranged.Herb Gynostemmae Pentaphylli foster the spirit of nobility spleen invigorating, QI invigorating and blood regulating, to hyperlipemia, heart deficiency of spleen-QI such as arteriosclerosis, distention and fullness in the abdomen and stagnation of phlegm blood stasis etc. have better curative effect.Semen Cassiae can be treated the many tears of conjunctival congestion and swelling pain, photophobia of liver-heat or wind-heat of liver channel, headache, hypertension and constipation with heat retention, and research recently has certain blood fat reducing and suppresses the atherosclerosis effect.Folium Ginkgo can extract acid in flavonoid and the Semen Ginkgo, and its composition removes has the coronary artery dilator blood vessel, the cerebral blood flow increasing amount, improves outside brain nutrition and the antibacterial action, also has stronger platelet, the inhibitory action of activation factor.Spica Prunellae liver heat removing and eyesight improving, heat clearing away are loose and are separated.Cure mainly liver-fire conjunctival congestion and swelling pain, headache, phlegm-fire smoulders and hypertension.Hawthorn digesting eliminate indigestion, regulating qi to disperse stagnation.Cure mainly meat stagnation, glutted stomachache, the dysentery of having loose bowels expectorant, hyperlipemia, blood pressure lowering etc.Folium Apocyni Veneti has blood pressure lowering, calmness, defying age, radioprotective, effects such as enhancing immunity.Chemical research composition to Herba Apocyni veneti only limits to Ye Hegen at present.Mel main component flavonoid and phenols studies show that, have multiple efficacies such as antibiotic, antiviral, antitumor, antioxidation, anti-inflammatory analgesic, anti-corrosive fresh-keeping, can enhancing human body immunity power, promote tissue regeneration.But all medicine compatible combination balance liver YANG hyperactivity suppressing, activating blood circulation to dissipate blood stasis, supplementing QI and nourishing YIN have the effect that reduces hypertension, hyperlipidemia, vessel softening, treating both the principal and secondary aspects of a disease.

For showing that medicine of the present invention is to hypertensive therapeutic effect, the present invention has carried out clinical observation on the therapeutic effect to 60 routine hyperpietics, and 60 routine hypertension experimenters (systolic pressure 〉=140mmHg, diastolic pressure 〉=90mmHg), age is 18-65 year, complication persons such as no severe cardiac Liver and kidney.60 routine experimenters are divided into test group and matched group (matched group, male 10 examples, women 20 examples; Test group, male 7 examples, women 23 examples).Each group adopts the own control design, is control design between group between two groups.Matched group and test group be former take the medicine kind and dosage constant, test group adds the holy recovery oral liquid of drink, every day 3 times, each 1 is flat 2, drank continuously 30 days.

The holy recovery oral liquid of table 1 to the influence of experimenter's systolic pressure (x ± SD, mmHg)

Group	Number	In the test-meal			After the test-meal
								Systolic pressure	P value (self)	The decline difference	Systolic pressure	P value (self)	The decline difference
		Matched group	30	150.73±10.64	0.22 2	-2.17±9.50	149.17±12.60							0.095	-3.73±12.41
Test group	30							137.93± 14.52**	0.00 0	-16.70±13.12##	140.10± 13.35**	0.000	-14.53±14.39##
		P value (between group)				0.000	0.002

* represents that self P＜0.01 ## represents between group relatively P＜0.01

In the test and after the test, test group and matched group and test be preceding self relatively to have systolic pressure all to reduce and difference has significance (P＜0.05); The systolic pressure decline difference of test group has significance (P＜0.05) greater than matched group and difference.

The holy recovery oral liquid of table 2 to the influence of experimenter's diastolic pressure (x ± SD, mmHg)

Group	Number	In the test-meal			After the test-meal
								Diastolic pressure	P value (self)	The decline difference	Diastolic pressure	P value (self)	The decline difference
		Matched group	30	95.47±7.88	0.14 7	-1.20±4.41	93.47±8.32**							0.001	-3.20±7.54

Test group	30	86.50±11.68**	0.00 0	-9.0±10.94##	88.67±6.94**	0.001	-6.83±10.38##
								P value (between group)		0.001			0.009

* represents that self P＜0.01 ## represents P＜0.01 between group

In the test and after the test, test group and matched group and test be preceding self relatively to have systolic pressure all to reduce and difference has significance (P＜0.05); The systolic pressure decline difference of test group has significance (P＜0.05) greater than matched group and difference.

The holy recovery oral liquid of table 3 is to the improvement situation of experimenter's clinical symptoms

	Matched group			Test group
							Project	Number	Effective number	Improvement rate (%)	Number	Effective number	Improvement rate (%)
Dizzy	15	7	46.7 0	16	10	62.50
							Headache	17	8	47.1 0	15	9	60.00
Cardiopalmus	19	9	47.4 0	21	12	57.14
							Insomnia	17	8	47.1 0	18	10	55.56

Result: take medicine oral liquid of the present invention, the test group blood pressure 14.53 ± 14.39/6.83 ± 10.38mmHg that on average descends, wherein effective 18 examples, total effective rate 60.00%; The matched group blood pressure 3.73/12.41 ± 3.20 ± 7.54mmHg that on average descends, wherein effective 8 examples, total effective rate 26.67%.Systolic pressure and diastolic pressure self comparing difference all have significance before and after two groups of experiments.After the test, the systolic pressure of test group and diastolic pressure decline difference all have significance (P＜0.05=greater than matched group and difference.

The oral liquid of medicine of the present invention improves significantly to symptoms such as hyperpietic headache, dizzy, cardiopalmus, insomnias.Take before and after the medicine oral liquid of the present invention, hemoglobin, erythrocyte, leukocyte, T-CHOL, triglyceride, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT, blood urea nitrogen, creatinine, blood glucose, total serum protein, serum albumin are all in normal range.

The specific embodiment

Embodiment 1:

Press following weight (part) proportioning weighting raw materials:

Radix Salviae Miltiorrhizae 15g Herba Cirsii 20g Herb Gynostemmae Pentaphylli 6g Semen Cassiae 6g

Folium Ginkgo 15g Spica Prunellae 6g Fructus Crataegi 8g Mel 4g

Folium Apocyni Veneti 15g;

Concrete production method is:

A, Herba Cirsii, Fructus Crataegi are cleaned roguing, add 5 times of water gagings and soak, soaking making beating filtration after 6 hours, medicinal liquid is standby;

B, Radix Salviae Miltiorrhizae, Herb Gynostemmae Pentaphylli, Folium Ginkgo, Spica Prunellae, Folium Apocyni Veneti, Semen Cassiae are cleaned roguing, decoct secondary, each 1 hour, add 5 times of water gagings at every turn, filter, filtrate and the merging of above-mentioned filtrate add Mel, are evaporated to 1/3rd of original volume;

C, placement when treating that fluid temperature is reduced to below 40 ℃, add 2 times of amounts, 95% ethanol sedimentation 24 hours, get supernatant and filter, and reclaim ethanol.Regulate pH value to 5.5, add water to 10000ml, shake up, leave standstill, filter, fill, the oral liquid product is made in sterilization.

Embodiment 2:

Take by weighing raw material by following weight (part) proportioning:

Radix Salviae Miltiorrhizae 20g Herba Cirsii 25g Herb Gynostemmae Pentaphylli 10g Semen Cassiae 10g

Folium Ginkgo 20g Spica Prunellae 10g Fructus Crataegi 15g Mel 6g

Folium Apocyni Veneti 20g.

Concrete production method is:

A, Herba Cirsii, Fructus Crataegi are cleaned roguing, add 5 times of water gagings and soak, soaking making beating filtration after 6 hours, medicinal liquid is standby;

B, Radix Salviae Miltiorrhizae, Herb Gynostemmae Pentaphylli, Folium Ginkgo, Spica Prunellae, Folium Apocyni Veneti, Semen Cassiae are cleaned roguing, decoct secondary, each 1 hour, add 5 times of water gagings at every turn, filter, filtrate and the merging of above-mentioned filtrate add Mel, are evaporated to 1/3rd of original volume;

C, placement when treating that fluid temperature is reduced to below 40 ℃, add 2 times of amounts, 95% ethanol sedimentation 24 hours, get supernatant and filter, and reclaim ethanol.Regulate pH value to 6.5, add water to 10000ml, shake up, leave standstill, filter, fill, the oral liquid product is made in sterilization.

Claims (4)

1. hypertensive medicine of treatment is characterized in that: the medicament of being made by the following materials based on weight medicine:

Radix Salviae Miltiorrhizae 10～20 Herba Cirsiis 15～25 Herb Gynostemmae Pentaphylli 5～10 Semen Cassiaes 5～10

Folium Ginkgo 10～20 Spica Prunellaes 5～10 Fructus Crataegis 5～15 Mel 3～6

Folium Apocyni Veneti 10～20.

2. the hypertensive medicine of treatment according to claim 1 is characterized in that: described medicament is a said dosage form on any pharmaceutics.

3. the hypertensive medicine of treatment according to claim 2, it is characterized in that: described medicament is an oral liquid.

4. the preparation method of the hypertensive medicine of the described treatment of claim 3 is characterized in that:

A, Herba Cirsii, Fructus Crataegi are cleaned roguing, add 5 times of water gagings and soak, soaking making beating filtration after 6 hours, medicinal liquid is standby;

B, Radix Salviae Miltiorrhizae, Herb Gynostemmae Pentaphylli, Folium Ginkgo, Spica Prunellae, Folium Apocyni Veneti, Semen Cassiae are cleaned roguing, decoct secondary, each 1 hour, add 5 times of water gagings at every turn, filter, filtrate and the merging of above-mentioned filtrate add Mel, are evaporated to 1/3rd of original volume;

C, placement when treating that fluid temperature is reduced to below 40 ℃, add 2 times of amounts, 95% ethanol sedimentation 24 hours, get supernatant and filter, and reclaim ethanol.Regulate pH value to 5.5～6.5, add water to 10000ml, shake up, leave standstill, filter, fill, sterilization makes.