CN104645252A

CN104645252A - Medicine for treating phlegm-turbidity closed resistance type coronary heart disease and preparation method thereof

Info

Publication number: CN104645252A
Application number: CN201510125164.1A
Authority: CN
Inventors: 任军; 陶银英
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-03-23
Filing date: 2015-03-23
Publication date: 2015-05-27

Abstract

The invention discloses a medicine for treating phlegm-turbidity closed resistance type coronary heart disease and a preparation method thereof. The medicine comprises the following raw medicinal materials: angelica sinensis, lignum dalbergiae odoriferae, white paeony root, cynomorium songaricum, cassia twig, rhodobryum roseum, asarum, lotus plumule, allium macrostemon, trichosanthes kirilowii maxim, fructus psoraleae, pinellia ternata, amethyst, semen brassicae, ophiopogon root, mulberry twig, lamiophlomis rotata, turmeric, rubia cordifolia, cinnamon, blighted wheat, astragalus, radix codonopsis, roasted rhizoma atractylodis macrocephalae, water dropwort, calcined keel, camphortree root, fructus aurantii, flower of official magnolia, betel nut, korean pine seed, semen boitae, semen aesculi, notopterygium, olgaea leucophylla, medicated leaven, oyster-cap fungus and oroxylum indicum. The medicine disclosed by the invention has the following beneficial effects: the medicine has the effects of warming and strengthening the heart-yang, promoting circulation and removing stasis, filling the heart fluid, dispersing the moisture, reconciling middle-Jiao and combing qi function, is mainly used for curing the phlegm turbidity closed resistance type coronary heart disease, and has the advantages of fast effectiveness, high effective rate, exact curative effect, short treatment course, zero toxic or side effect, low price and the like.

Description

A kind ofly treat medicine of expectorant turbid impatency type coronary heart disease and preparation method thereof

Technical field

The present invention relates to technical field of pharmaceuticals, particularly a kind ofly treat medicine of expectorant turbid impatency type coronary heart disease and preparation method thereof.

Background technology

Coronary heart disease, the ancient title thoracic obstruction, a kind of modal heart disease, refer to because of coronary stricture, blood supply insufficiency and the myocardial dysfunction caused or organic disease, therefore also known as ischemic heart desease, ischemic heart desease is the result of multiple coronary artery disease, but coronary atherosclerosis accounts for the overwhelming majority of coronary heart disease.

The pathogeny of coronary heart disease: said coronary heart disease majority is that tremulous pulse organic stenosis or obstruction cause at ordinary times, also known as coronary atherosclerotic heart disease, caused by its coronary stricture polyphyly fatty material is piled up along blood vessel, this process is called arteriosclerosis, and arteriosclerosis develops into a certain degree, and coronary stricture increases the weight of gradually, restriction flows into the blood flow of cardiac muscle, heart can not get enough oxygen supplies, chest discomfort will occur, i.e. angina pectoris.

The clinical symptoms of coronary heart disease: the angina pectoris attacks performance of different people differs.Majority describe that it is " pressure in chest ", " vexed swollen sense " " sense of feeling oppressed ", and some patients's sensation is diffused to bilateral shoulder, back, cervical region, bottleneck throat, have a rest or the alleviation of buccal nitroglycerin.

Analyze the cause of disease of coronary heart disease, mostly be precordial pain with cold limbs, angina pectoris, the obstruction of heart-QI, the thoracic obstruction etc., therefore distinguish that its clinical syndrome is divided into: 1, angina pectoris: show as retrosternal squeezing sense, vexed swollen sense, with obvious anxiety, continue 3 to 5 minutes, often diffuse to left side arm, shoulder, lower jaw, bottleneck throat, back, also can emit to right arm. and sometimes can involve these positions and not affect breastbone back zone, firmly, excited, catch cold, what heavy meal etc. were shown effect under increasing myocardial oxygen consumption situation is called effort angina, has a rest and dissolving nitroglycerin in mouth alleviation.Sometimes angina pectoris is not true to type, and can show as gas tight, faint, and weak, belch, especially old people.Stable type and unstable angina pectoris is divided into according to the frequency of showing effect and the order of severity.Stable angina pectoris refers to the effort angina in January of showing effect more than, its position of showing effect, frequency, and the order of severity, the persistent period, lures labour's size of outbreak into, and the lenitive nitroglycerin consumption of energy is basicly stable.What unstable angina pectoris referred to makes original stable angina pectoris seizure frequency, the persistent period, and the order of severity increases, or the effort angina (occurring within 1 month) of new outbreak, or the angina pectoris shown effect during tranquillization.Unstable angina pectoris is the omen of acute myocardial infarction, so once find to go to see a doctor immediately.2, myocardial infarction: infraction often has prodrome about there is the last week, as the angina pectoris shown effect when tranquillization and slight physical exertion, tired out with significantly not accommodating.Show as persistence violent constriction during infraction, vexed plug sense, even cutting pains, after being positioned at breastbone, ordinary wave and whole shirtfront, attach most importance to left side.Some patients can prolong left arm ulnar side and radiate downwards, causes left side wrist, and palm and finger tingling, some patients can be radiated to upper limb, shoulder, cervical region, and lower jaw, based on left side.Painful area and former angina pectoris positions are conformed to each other, but continue more of a specified duration, pain is heavier, and rest and dissolving nitroglycerin in mouth can not be alleviated.Sometimes show as epigastrium pain, easy and celiac disease is obscured.With low grade fever, dysphoria, hyperhidrosis and cold sweat, feel sick, vomiting, and cardiopalmus is dizzy, extremely weak, dyspnea, and dying sense continues more than 30 minutes, often reaches a few hours.Find that this situation should be gone to a doctor immediately.3, silent myocardial ischemia type (latent coronary heart disease): a lot of patient has coronary occlusion widely but not feel angina pectoris, and even some patient does not also feel angina pectoris when myocardial infarction.Some patients there occurs sudden cardiac death, finds just to be found after myocardial infarction during routine physical examination. and some patients has ischemia show due to electrocardiogram, there occurs arrhythmia, or does coronary angiography because of the exercise test positive and just find.It is the same with there being anginal patient with the chance of myocardial infarction to there is sudden cardiac death in this kind of patient, so should note heart health at ordinary times.4, heart failure and arrhythmia type: the original angina pectoris attacks of some patients, later because pathological changes is extensive, cardiac muscle is fibrosis extensively, and angina pectoris reduces to disappearance gradually, but occurs the performance of heart failure, as gas is tight, edema, weak etc., also have various arrhythmia, show as cardiopalmus. also have some patients never angina pectoris, and directly translate into heart failure and arrhythmia.5, sudden death type: refer to the uncertain sudden death because coronary heart disease causes, occurs caused by sudden cardiac arrest in 6 hours after acute symptom occurs.Mainly because ischemia causes myocardial cell bioelectrical activity abnormal, and there is severe arrhythmia and cause.The Clinical types of coronary heart disease: Clinical typing is with the typing of the World Health Organization (WHO) for standard, that is: angina pectoris, myocardial infarction and sudden death; Angina pectoris can be divided into not only effort angina and spontaneous angina pectoris (1) effort angina but also divide 3 classes, and one is de novo angina pectoris; Two is stable effort anginas; Three is worsen effort angina.(2) angina pectoris that shows effect under referring generally to resting state of spontaneous angina pectoris.Wherein by accompanying the ST section person of raising during angina pectoris attacks, be called variant angina pectoris.Coronary heart disease is called for short coronary heart disease.Refer to that, because lipid metabolism is abnormal, the lipid in blood is calm on the endarterium of otherwise smooth, pile up at the lipid material of some similar medicated porridge samples of endarterium and form white speckle, be called atherosclerotic lesion.These specklees gradually increase and cause lumen of artery narrow, blood flow is obstructed, causes heart ischemia, produce angina pectoris.

The classification of coronary heart disease: conceal type: patient has coronary atherosclerosis, but pathological changes is comparatively light or have good Doppler flow mapping, or the patient threshold of pain is higher thus without pain symptom.Angina pectoris: on the basis of coronary stricture, the increase due to myocardial muscle load cause cardiac muscle sharply, the clinical syndrome of of short duration ischemia and anoxia., there is coronary artery blood supply and sharply reduce or interrupt in myocardial infarction type: on the basis of coronary artery pathological changes, make corresponding cardiac muscle seriously and enduringly acute ischemia cause myocardial necrosis.Heart failure type: (ischemic cardiomyopathy) myocardial fibrosis, the blood of cardiac muscle is for long-term not enough, and malnutrition and atrophy occur in cardiac muscular tissue, or after Large Area Myocardial Infarction, so that caused by proliferation of fibrous tissue.Sudden death type: patient's heart all standing be due on atherosclerotic basis, there is coronary vasospasm or thromboembolism, cause Acute myocardial ischemia, cause local electric physiologic derangement, cause caused by temporary transient severe arrhythmia.

Coronary heart disease cause: coronary heart disease is the type reaction of system vascular pathological changes, no matter how serious its reason of coronary heart disease, be that coronary artery blockage causes, and this blocking is all coronary atherosclerosis causes, and atherosis be all the thing eaten too delicious food savoury cause.Show as the deficiency of vital energy, mainly refer to deficiency of kidney-QI, mean that your congenital gas is just not enough.The Etiological of coronary heart disease is coronary atherosclerosis, but atherosclerotic reason still imperfectly understands, may be the result of many factors comprehensive function. think that this pathogenetic risk factor has: age and the sex (male of more than 45 years old, more than 55 years old or postclimacteric women), (low-density lipoprotein cholesterol LDL-C is too high for dyslipidemia, HDL-C HDL-C is too low), hypertension, glucose in urine is sick, smoking, overweight, obesity, gout, not move.

The diagnostic method of coronary heart disease: (1) clinical manifestation: angina pectoris is the main clinic symptoms of coronary heart disease, just angina pectoris and myocardial infarction can be differentiated according to the features such as position during angina pectoris attacks, character, inducement, persistent period, alleviation mode and simultaneous phenomenon and sign, can say, the diagnosis of typical sings and symptoms to angina pectoris and myocardial infarction is most important.(2) electrocardiogram: electrocardiogram be in diagnosis of coronary heart disease the earliest, the most frequently used and the most basic diagnostic method, electrocardiogram is easy to use, be easy to universal, just its situation of change can be caught in time when conditions of patients changes, and can dynamically observe continuously and carry out various stress test, to improve its diagnostic sensitivity.No matter be angina pectoris or myocardial infarction, have its typical ECG Change.(4) Nuclear Cardiac Imaging: according to medical history, can do this top and check when Electrocardioscopy can not get rid of angina pectoris.Nuclear Cardiac Imaging can show ischemic region, the position of clear and definite ischemia and range size.In conjunction with exercise test video picture again, recall rate can be improved.(5) coronarography: be current diagnosis of coronary heart disease " goldstandard ".Coronary artery can be specified with or without narrow, narrow position, degree, scope etc., and the measure for the treatment of further and should take can be instructed accordingly.(6) ultrasonic and intravascular ultrasound: cardiac ultrasonic can check cardiac shape, ventricular wall motion and left ventricular function is one of the most frequently used at present detection methods.Intravascular ultrasound can specify IC tube wall form and stenosis, is a very promising new technique.Be particularly useful for contrast medium sensitivity, can not coronarography person be.(7) Myocardial Enzymologic inspection: be one of important means of the diagnosis and differential diagnosis of acute myocardial infarction.Change according to certainty zymetologys such as the sequence variation of sero-enzyme concentration and the risings of specificity isozyme clinically and can clarify a diagnosis as acute myocardial infarction.(8) cardiac blood pool imaging: can be used for the dynamic image observing ventricle wall contraction and diastole, for determining that ventricular wall motion and cardiac function have important references to be worth.Auxiliary examination: ordinary electrocardiogram: most of patients with coronary artery disease, does not have electrocardiogram during paresthesia epilepsy to be all normal, or normal. so normal ECG can not get rid of coronary heart disease.Treadmill Exercise Test (ECG exercise test): the accuracy of its diagnosis of coronary heart disease is about 70%. certainly, exercise test has certain risk, has strict indication and contraindication. and as acute myocardial infarction, unstable angina pectoris, do not have the hypertension, heart failure, acute heart and lung diseases etc. controlled to belong to the absolute contraindication of exercise test.Myocardial Radionuclide perfusion scanning (nuclear medicine): the accuracy of its diagnosis of coronary heart disease (angina pectoris) be also 70%. but the accuracy making a definite diagnosis myocardial infarction close to 100%.Coronary angiography with CT: the accuracy of diagnosis of coronary heart disease reaches more than 90%, can detect the early stage arteriosclerosis that other inspections cannot find.Ambulatory electrocardiogram (Holter): (1) records various arrhythmia; (2) 12 lead HOLTER: record silent myocardial ischemia; Relatively force down with or without S-T section, with the character of clear and definite chest pain during chest pain; (3) accompany S-T section to raise during chest pain, contribute to making a definite diagnosis coronary vasospasm (variant angina pectoris).Ultrasoundcardiogram: be the extremely valuable inspection of Diagnosing Cardiac disease.(1) make a definite diagnosis or get rid of multiple organic heart disease (congenital heart disease, rheumatic heart disease, cardiomyopathy); (2) angina pectoris: most humans ultrasoundcardiogram is normal; (3) acute myocardial infarction, old myocardial infarction: have clear and definite Abnormal Wall Motion, ultrasoundcardiogram can make a definite diagnosis this two classes disease.

TCM knowledge: the Chinese medical discrimination of coronary heart disease, following several type can be summarized as: (1) heart-yang deficiency, stagnation of QI causing phlegm retention mechanism of qi: show as uncomfortable in chest, headache, cardiopalmus, breathe hard, pale complexion or dim stagnant, the tender white and moist fur of cold extremities with aversion to cold, spontaneous perspiration, clear urine in large amounts, soft stools, enlarged tongue, moderate pulse sliding or knot generation.(2) the deficient type of the heart-yin, blockage of qi mechanism by phlegm: show as cardiopalmus, pained, feel suffocated, xerostomia, tinnitus, dizzy, night sweat, night sleep peaceful, the light red white and thin fur of frequent urination at night, waist soreness, tongue or no fur, thready and rapid pulse and short or thin wet and tie.(3) cold coagulation heart arteries and veins type: soldier so has an excruciating pain in the chest, cold physique, cold weather or meet cold wind then pained easy outbreak or aggravation, very then hands and feet being not warm, and cold sweat goes out, cardiopalmus of breathing hard, chest pain radiating to the back, backache radiating to the heart, tense pulse, white and thin fur.(4) pathogenic fire accumulation of heat type: causalgia in the heart, xerostomia, irritated, rough, expectorant is thick, or has heating, constipation, red tongue, yellow fur or rough, rapid pulse or sliding number.(5) stagnation of QI ambition type: ambition is full vexed, and dull pain is a burst of, migratory pain, time for heaving a deep sigh, meet feelings and freely then do not bring out, aggravate, maybe can have wrist concurrently swollen, obtain heating installation, the arrow gas then disease such as easypro, thin fur or thin greasy, thready and stringy pulse.(6) expectorant turbid impatency type: the different diseases such as phlegm retention, expectorant are turbid, phlegm-fire, wind-phlegm can be divided into.Phlegm retention person, uncomfortable in chest heavy and pained gently, meet the cloudy day and easily do, expectoration, tongue is greasy or whiten in vain, rolling pulse; Hold concurrently wet person, then visible mouth glues, and feels sick, indigestion and loss of appetite, asthenia, or the just disease such as soft.The turbid person of expectorant, uncomfortable in chest and double pained time do, expectorant glues the white greasy band of tongue to be done, or yellowish greasy, if expectorant is thick, color or Huang, defecate partially dry, greasy fur or dry, or yellow greasy, be then that expectorant is warm.Phlegm-fire person, uncomfortable in chest, make causalgia during ambition, the yellow stiff of expectorant, vexed, xerostomia, large dry stool or secret, yellow and greasy fur, slippery and rapid pulse.Wind-phlegm person, time uncomfortable in chest, pain, and is shown in tongue hemiplegia, dizzy, and brothers tremble the disease of numbness, greasy fur, stringy and rolling pulse.(7) Yu Xue Bi closed form: ambition pain is more acute, if thorn is as strand, localized pain, with uncomfortable in chest, does not with the passing of time heal, or can be caused ambition severe pain by rage.Thin fur, tongue are dark red, purple is dark or have ecchymosis, or Sublingual blood vessels are livid purple, stringy and hesitant pulse or knot generation.(8) deficiency of heart-QI type: a burst of dull pain in ambition, sensation of oppression over the chest with shortness of breath, dynamic then pant, cardiopalmus and flurried, fatigue and weakness, or lazy speech, pale complexion, or easily sweating, light red tongue is fat, has indentation, thin fur, deficient and thready pulse slow or knot generation.

Current treatment ACA method has: 1, angina pectoris: should stop physical exertion immediately, have a rest on the spot, manages to eliminate the inducements such as cold, excited; Sublingual administration nitroglycerin or sorbitrate 1 immediately, as do not alleviated, every 5 to 10 minutes again containing changing once, continuous 3 times invalid containing changing, chest pain continues more than 15 minutes persons to be had the possibility of myocardial infarction occurs, and the first aid place such as should to send immediately to hospital; Can oral diazepam 3 milligrams, the person of having ready conditions answers oxygen uptake 10 to 30 minutes.Patients with coronary artery disease should carry with the medicines such as nitroglycerin, once there is chest pain buccal immediately, and notes the medicine not using inefficacy.Stable angina pectoris angina pectoris after rest and dissolving nitroglycerin in mouth can be alleviated, and unstable angina pectoris is a seriously disease for potential danger, should send treatment and close observation immediately to hospital.2, myocardial infarction: acute myocardial infarction mortality rate is high, wherein patient more than half is living pre hospital time, and most of death occurs in falls ill in latter 1 hour, is generally caused by ventricular fibrillation.So emergency treatment and to pass on rapidly hospital most important on the spot.Once there is following situation in high risk patient (hypertension, diabetes, the person that previously has angina pectoris attacks): chest is uncomfortable, extremely tired, dyspnea, especially with profuse sweating, giddy, cardiopalmus, during dying sense, strong suspicion is wanted to there occurs myocardial infarction, should send nearest immediately, have ready conditions and make electrocardiogram, cardiac monitoring, unidirectional current defibrillation, the medical institutions of intravenous thrombolysis.Keep calm simultaneously, do not cause that patient's is alarmed and frightened, and dissolving nitroglycerin in mouth, or SUXIAO JIUXIN WAN, arklemin closes ball etc., and having ready conditions can intramuscular injection papaverine, or dolantin, and stable, and keep ventilating and oxygen uptake, as without contraindication, oral aspirin 300 milligrams immediately.As generation chamber speed, the room malignant arrhythmia such as to quiver gives unidirectional current defibrillation immediately.Once generation sudden cardiac arrest, artificial respiration and closed cardiac massage cardio-pulmonary resuscitation should be carried out immediately.3, acute heart failure and cardiogenic shock: acute myocardial infarction and Ischemic cardiomyopathy all acute heart failure may occur, caused by large area myocardial necrosis. mostly be acute left heart failure, there is severe dyspnea in patient, companion's dysphoria, sensation of asphyxia, complexion is steel gray, die Blausucht, dripping sweat, cough, cough up a large amount of white or pink foam expectorant, this situation must send rescue to hospital immediately.

The medicine of coronary heart disease, intervention, operation are put up a bridge and are treated: medicine can only control symptom, can stablize the speckle in coronary artery.The shortcoming of heart coronary artery bypass or intervention support: coronary angioplasty (being called for short PTCA) is a kind of effective ways for the treatment of coronary heart disease.Conduit is inserted the diseased region of coronary stricture or obstruction by this operation, makes balloon expandable, plays blood vessel dilating, improves the therapeutical effect of blood supply of cardiac muscle.Over nearly 10 years, PTCA develops into well accepted conventional therapy means in world wide.But also find the patient accepting this therapy, about there is arteria coronaria in 30% to 50% half a year after surgery restenosis can occur again, this has become a great problem having a strong impact on patients with coronary heart disease curative effect. simultaneously, the problem that support ruptures in vivo is also more and more outstanding, may have influence on the unexpected generation of myocardial infarction.

Summary of the invention

Technical problem to be solved by this invention is, there is provided a kind of and treat medicine of expectorant turbid impatency type coronary heart disease and preparation method thereof, the present invention has temperature and to shake effect of heart-yang, hold concurrently with blood circulation promoting and blood stasis dispelling, fill up effect that is burnt in heart liquid, a surname's aproll gas, mediation, combing mechanism of qi, cure mainly expectorant turbid impatency type coronary heart disease, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

In order to solve the problems of the technologies described above, the invention provides a kind of medicine for the treatment of expectorant turbid impatency type coronary heart disease, wherein, following raw medicinal material is comprised: Radix Angelicae Sinensis, Lignum Dalbergiae Odoriferae, the Radix Paeoniae Alba, Herba Cynomorii, Ramulus Cinnamomi, Rhodobryum roseum Limpr., Herba Asari, Plumula Nelumbinis, Bulbus Allii Macrostemonis, Fructus Trichosanthis, Fructus Psoraleae, the Rhizoma Pinelliae, Fluoritum, Semen Sinapis Albae, Radix Ophiopogonis, Ramulus Mori, Radix Lamiophlomidis Rotatae, Rhizoma Curcumae Longae, Radix Rubiae, Cortex Cinnamomi, Fructus Tritici Levis, the Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Herba Oenanthes Javanicae, Os Draconis (calcined), Radix Cinnamomi Camphorae, Fructus Aurantii, Flos Magnoliae Officinalis, Semen Arecae, Semen pini koraiensis, Semen Platycladi, Semen Aesculi, Rhizoma Et Radix Notopterygii, Herba Olgaeae leucophyllae, Massa Medicata Fermentata, to pick up the ears and Semen Oroxyli.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 15 ~ 35 parts, Lignum Dalbergiae Odoriferae 12 ~ 22 parts, the Radix Paeoniae Alba 11 ~ 31 parts, Herba Cynomorii 14 ~ 34 parts, Ramulus Cinnamomi 15 ~ 35 parts, Rhodobryum roseum Limpr. 12 ~ 20 parts, Herba Asari 10 ~ 32 parts, Plumula Nelumbinis 13 ~ 33 parts, Bulbus Allii Macrostemonis 14 ~ 28 parts, Fructus Trichosanthis 15 ~ 25 parts, Fructus Psoraleae 12 ~ 30 parts, the Rhizoma Pinelliae 3 ~ 5 parts, Fluoritum 12 ~ 32 parts, Semen Sinapis Albae 11 ~ 21 parts, Radix Ophiopogonis 13 ~ 27 parts, Ramulus Mori 13 ~ 32 parts, Radix Lamiophlomidis Rotatae 3 ~ 5 parts, 15 ~ 35 parts, Rhizoma Curcumae Longae, 12 ~ 20 parts, Radix Rubiae, Cortex Cinnamomi 15 ~ 35 parts, Fructus Tritici Levis 10 ~ 30 parts, the Radix Astragali 10 ~ 20 parts, Radix Codonopsis 12 ~ 28 parts, Rhizoma Atractylodis Macrocephalae (parched) 14 ~ 34 parts, Herba Oenanthes Javanicae 12 ~ 26 parts, Os Draconis (calcined) 15 ~ 35 parts, Radix Cinnamomi Camphorae 14 ~ 28 parts, Fructus Aurantii 16 ~ 36 parts, Flos Magnoliae Officinalis 10 ~ 20 parts, Semen Arecae 15 ~ 25 parts, Semen pini koraiensis 14 ~ 28 parts, Semen Platycladi 13 ~ 30 parts, Semen Aesculi 15 ~ 25 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Herba Olgaeae leucophyllae 15 ~ 35 parts, Massa Medicata Fermentata 13 ~ 23 parts, to pick up the ears 14 ~ 32 parts and Semen Oroxyli 10 ~ 20 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 15 ~ 35 parts, Lignum Dalbergiae Odoriferae 14 ~ 22 parts, the Radix Paeoniae Alba 13 ~ 30 parts, Herba Cynomorii 15 ~ 34 parts, Ramulus Cinnamomi 15 ~ 35 parts, Rhodobryum roseum Limpr. 14 ~ 20 parts, Herba Asari 12 ~ 32 parts, Plumula Nelumbinis 13 ~ 32 parts, Bulbus Allii Macrostemonis 14 ~ 25 parts, Fructus Trichosanthis 15 ~ 22 parts, Fructus Psoraleae 14 ~ 30 parts, the Rhizoma Pinelliae 3 ~ 5 parts, Fluoritum 13 ~ 30 parts, Semen Sinapis Albae 12 ~ 20 parts, Radix Ophiopogonis 14 ~ 28 parts, Ramulus Mori 15 ~ 32 parts, Radix Lamiophlomidis Rotatae 3 ~ 5 parts, 15 ~ 35 parts, Rhizoma Curcumae Longae, 15 ~ 20 parts, Radix Rubiae, Cortex Cinnamomi 15 ~ 35 parts, Fructus Tritici Levis 12 ~ 30 parts, the Radix Astragali 14 ~ 20 parts, Radix Codonopsis 12 ~ 25 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 ~ 33 parts, Herba Oenanthes Javanicae 15 ~ 25 parts, Os Draconis (calcined) 15 ~ 35 parts, Radix Cinnamomi Camphorae 14 ~ 26 parts, Fructus Aurantii 16 ~ 34 parts, Flos Magnoliae Officinalis 12 ~ 20 parts, Semen Arecae 15 ~ 25 parts, Semen pini koraiensis 15 ~ 28 parts, Semen Platycladi 15 ~ 30 parts, Semen Aesculi 15 ~ 25 parts, Rhizoma Et Radix Notopterygii 12 ~ 20 parts, Herba Olgaeae leucophyllae 15 ~ 35 parts, Massa Medicata Fermentata 15 ~ 20 parts, to pick up the ears 15 ~ 32 parts and Semen Oroxyli 10 ~ 20 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 25 parts, Lignum Dalbergiae Odoriferae 17 parts, the Radix Paeoniae Alba 30 parts, Herba Cynomorii 20 parts, Ramulus Cinnamomi 15 parts, Rhodobryum roseum Limpr. 17 parts, Herba Asari 12 parts, Plumula Nelumbinis 32 parts, Bulbus Allii Macrostemonis 24 parts, Fructus Trichosanthis 20 parts, Fructus Psoraleae 30 parts, the Rhizoma Pinelliae 3 parts, Fluoritum 25 parts, Semen Sinapis Albae 15 parts, Radix Ophiopogonis 20 parts, Ramulus Mori 32 parts, Radix Lamiophlomidis Rotatae 3 parts, 33 parts, Rhizoma Curcumae Longae, 20 parts, Radix Rubiae, Cortex Cinnamomi 35 parts, Fructus Tritici Levis 26 parts, the Radix Astragali 15 parts, Radix Codonopsis 22 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 parts, Herba Oenanthes Javanicae 25 parts, Os Draconis (calcined) 35 parts, Radix Cinnamomi Camphorae 24 parts, Fructus Aurantii 34 parts, Flos Magnoliae Officinalis 12 parts, Semen Arecae 17 parts, Semen pini koraiensis 28 parts, Semen Platycladi 15 parts, Semen Aesculi 24 parts, Rhizoma Et Radix Notopterygii 16 parts, Herba Olgaeae leucophyllae 35 parts, Massa Medicata Fermentata 20 parts, to pick up the ears 19 parts and Semen Oroxyli 12 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 15 parts, Lignum Dalbergiae Odoriferae 22 parts, the Radix Paeoniae Alba 30 parts, Herba Cynomorii 32 parts, Ramulus Cinnamomi 20 parts, Rhodobryum roseum Limpr. 15 parts, Herba Asari 32 parts, Plumula Nelumbinis 22 parts, Bulbus Allii Macrostemonis 15 parts, Fructus Trichosanthis 22 parts, Fructus Psoraleae 30 parts, the Rhizoma Pinelliae 3 parts, Fluoritum 15 parts, Semen Sinapis Albae 20 parts, Radix Ophiopogonis 28 parts, Ramulus Mori 32 parts, Radix Lamiophlomidis Rotatae 3 parts, 25 parts, Rhizoma Curcumae Longae, 20 parts, Radix Rubiae, Cortex Cinnamomi 33 parts, Fructus Tritici Levis 14 parts, the Radix Astragali 20 parts, Radix Codonopsis 14 parts, Rhizoma Atractylodis Macrocephalae (parched) 32 parts, Herba Oenanthes Javanicae 24 parts, Os Draconis (calcined) 35 parts, Radix Cinnamomi Camphorae 24 parts, Fructus Aurantii 32 parts, Flos Magnoliae Officinalis 20 parts, Semen Arecae 15 parts, Semen pini koraiensis 24 parts, Semen Platycladi 30 parts, Semen Aesculi 25 parts, Rhizoma Et Radix Notopterygii 14 parts, Herba Olgaeae leucophyllae 32 parts, Massa Medicata Fermentata 20 parts, to pick up the ears 32 parts and Semen Oroxyli 20 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 35 parts, Lignum Dalbergiae Odoriferae 22 parts, the Radix Paeoniae Alba 30 parts, Herba Cynomorii 24 parts, Ramulus Cinnamomi 33 parts, Rhodobryum roseum Limpr. 20 parts, Herba Asari 32 parts, Plumula Nelumbinis 13 parts, Bulbus Allii Macrostemonis 25 parts, Fructus Trichosanthis 22 parts, Fructus Psoraleae 30 parts, the Rhizoma Pinelliae 3 parts, Fluoritum 20 parts, Semen Sinapis Albae 15 parts, Radix Ophiopogonis 22 parts, Ramulus Mori 32 parts, Radix Lamiophlomidis Rotatae 3 parts, 35 parts, Rhizoma Curcumae Longae, 20 parts, Radix Rubiae, Cortex Cinnamomi 33 parts, Fructus Tritici Levis 14 parts, the Radix Astragali 20 parts, Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 33 parts, Herba Oenanthes Javanicae 22 parts, Os Draconis (calcined) 35 parts, Radix Cinnamomi Camphorae 24 parts, Fructus Aurantii 34 parts, Flos Magnoliae Officinalis 20 parts, Semen Arecae 25 parts, Semen pini koraiensis 15 parts, Semen Platycladi 30 parts, Semen Aesculi 22 parts, Rhizoma Et Radix Notopterygii 14 parts, Herba Olgaeae leucophyllae 35 parts, Massa Medicata Fermentata 17 parts, to pick up the ears 25 parts and Semen Oroxyli 15 parts.

When the dosage form of described medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

When the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85% ~ 95%, reflux 4 ~ 6 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 400 order ~ 500 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.2 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

When the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:

The first step, by Radix Cinnamomi Camphorae, Fructus Aurantii, Flos Magnoliae Officinalis, Semen Arecae, Semen pini koraiensis, Semen Platycladi, Semen Aesculi, Rhizoma Et Radix Notopterygii, Herba Olgaeae leucophyllae, Massa Medicata Fermentata, pick up the ears and Semen Oroxyli mixing, add relative to mixture 6 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 3 times, each 3 ~ 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37 ~ 1.39, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.36;

3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 80%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 70 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described medicine oral liquid finished product.

The invention has the beneficial effects as follows: the present invention has temperature and to shake effect of heart-yang, hold concurrently with blood circulation promoting and blood stasis dispelling, fill up effect that is burnt in heart liquid, a surname's aproll gas, mediation, combing mechanism of qi, cure mainly expectorant turbid impatency type coronary heart disease, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

Detailed description of the invention

The invention provides a kind of medicine for the treatment of expectorant turbid impatency type coronary heart disease, the present invention follows temperature and to shake the Therapeutic Principle of heart-yang, have blood circulation promoting and blood stasis dispelling concurrently, fill up heart liquid, a surname's aproll gas, burnt in mediation, effect of combing mechanism of qi, wherein, comprise following raw medicinal material: Radix Angelicae Sinensis, Lignum Dalbergiae Odoriferae, the Radix Paeoniae Alba, Herba Cynomorii, Ramulus Cinnamomi, Rhodobryum roseum Limpr., Herba Asari, Plumula Nelumbinis, Bulbus Allii Macrostemonis, Fructus Trichosanthis, Fructus Psoraleae, the Rhizoma Pinelliae, Fluoritum, Semen Sinapis Albae, Radix Ophiopogonis, Ramulus Mori, Radix Lamiophlomidis Rotatae, Rhizoma Curcumae Longae, Radix Rubiae, Cortex Cinnamomi, Fructus Tritici Levis, the Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Herba Oenanthes Javanicae, Os Draconis (calcined), Radix Cinnamomi Camphorae, Fructus Aurantii, Flos Magnoliae Officinalis, Semen Arecae, Semen pini koraiensis, Semen Platycladi, Semen Aesculi, Rhizoma Et Radix Notopterygii, Herba Olgaeae leucophyllae, Massa Medicata Fermentata, pick up the ears and Semen Oroxyli.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Pick up the ears: source: begin to be loaded in " Xinhua's book on Chinese herbal medicine outline ".Nature and flavor: pungent; Sweet; Warm in nature.Gui Jing: liver; Kidney channel.Cure mainly: wind-evil dispelling and cold-evil expelling; Relaxing muscles and tendons and activating QI and blood in the collateral; Kidney invigorating and YANG supporting.Main lumbago and skelalgia; Numb hand and foot; Grain does not relax; Impotence and seminal emission, weakness of the waist and knees.

Herba Olgaeae leucophyllae: nature and flavor: sweet is cool.Cure mainly: blood stasis removing and clots absorbing, removing heat from blood, hemostasis.Cure mainly wound, hemorrhage, spit blood, epistaxis, anovulatory dysfunctional uterine hemorrhage; Sore carbuncle is controlled in external.

Semen Aesculi: nature and flavor: sweet, temperature.Gui Jing: return liver, stomach warp.Cure mainly: regulating the flow of QI to ease the stomach, and stomach and alleviating pain.Vexed for breast abdominal distention, gastralgia.

Semen pini koraiensis: source: " Kaibao Bencao ".Nature and flavor: sweet, temperature.Gui Jing: enter liver, lung, large intestine channel.Cure mainly: nutrient solution, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., lung moistening, laxation, control migratory arthralgia, dizziness, cough caused by dryness, spit blood, constipation." Kaibao Bencao ": " main joint wind, dizziness, removes dead flesh, bleach, aproll gas, and moistening five ZANG-organs is not hungry."

Flos Magnoliae Officinalis: nature and flavor: bitter, tepor.Gui Jing: return spleen, stomach warp.Cure mainly: regulate the flow of vital energy, removing dampness.For the vexed distension of breast gastral cavity painful abdominal mass, poor appetite.

Radix Cinnamomi Camphorae: source: come from " classifying herbal ".Nature and flavor: pungent; Temperature.Gui Jing: liver; Spleen channel.Cure mainly: warming middle-JIAO to relieve pain; Ward off dirty and in; Expelling wind and removing dampness.Main gastralgia; Cholera is vomited and diarrhoea; Rheumatic arthralgia; Skin pruritus." Kweiyang medicinal herbs among the people ": regulate the flow of vital energy, promoting the circulation of blood, stomach invigorating.Control gastropathy, bones and muscles pain, bromhidrosis, sweaty foot.

Herba Oenanthes Javanicae: source: " a thousand pieces of gold wing book on Chinese herbal medicine ".Nature and flavor: Gan Xin are cool.Gui Jing: enter lung, stomach warp.Cure mainly: heat clearing away, diuretic.Control sudden high fever excessive thirst, jaundice, edema, gonorrhea, leukorrhagia, scrofula, mumps." medical center bun is wanted ": " reinforcing the heart, blood stasis removing, continuous wound."

Radix Codonopsis: nature and flavor: sweet is flat.Gui Jing: return spleen, lung meridian.Cure mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Fructus Tritici Levis: nature and flavor: sweet is cool.Cure mainly: only sweating due to debility, tranquilizing by nourishing the heart.For the empty hyperhidrosis of body, hysteria.

Radix Rubiae: nature and flavor: bitter, cold.Gui Jing: return Liver Channel.Cure mainly: removing heat from blood and promoting blood circulation, blood stasis dispelling, stimulate the menstrual flow.For haematemesis, epistaxis, metrostaxis, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling.

Radix Lamiophlomidis Rotatae: nature and flavor: bitter, is slightly cold.Cure mainly: blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.For traumatic injury, fracture, lumbar strain.

Radix Ophiopogonis: source: come from Shennong's Herbal.Nature and flavor: sweet; Micro-hardship; Cold.Gui Jing: lung; Stomach; Heart channel.Cure mainly: nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Clear away heart-fire relieving restlessness.Main dryness of the lung dry cough; Lung abscess; Deficiency of YIN chronic cough; Tianjin wound is thirsty; Quench one's thirst; Vexed insomnia; Have sore throat; Dryness of the intestine constipation; Heat in blood tells nosebleed." book on Chinese herbal medicine converges and says ": Radix Ophiopogonis, the medicine of clearing away heart-fire and moistening the lung also.Main deficiency of heart-QI, palpitation with fear palpitation with a distress feeling, dimly forgetful, spirit fall; Or the lung-heat dryness of the lung, cough sound running fire, consumptive lung disease leaf scorch, dyspnea due to deficiency of losing heart, in fire volt lung, spitting of blood hemoptysis; Or asthenia exopathogenic heat, body fluid is dry few; Or taste are dry dries up, constipation due to insufficiency dyschezia.

Fluoritum: source: 1. " WU Pu Bencao ": Fluoritum, raw Taishan maybe can be checked.Adopt without time.For order as cut, purple reaches head, as an ancient game person.2. TAO Hong-Jing: Fluoritum, modern first use Taishan stone, and color weight is clear, under have root.Use mixedly when first, the modern ball family that falls apart selects only Taishan and wins most, and remaining place person can make ball wine bait.3. " medicine to ": (Fluoritum) Poria, Radix Ginseng, Radix Paeoniae treat stagnation of QI in the heart altogether; Radix Aconiti, calamus treat cholera altogether.Nature and flavor: sweet; Pungent; Temperature; Nontoxic.Gui Jing: the heart; Liver; Lung; Kidney channel.Cure mainly: relieving palpitation; Calm the nerves; Lowering the adverse flow of QI; Warm uterus.Main cardiopalmus; Palpitation with a distress feeling; Infantile convulsion; Lung cold cough with dyspnea.

Fructus Psoraleae: nature and flavor: pungent, bitter, temperature.Gui Jing: return kidney, spleen channel.Cure mainly: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.

Plumula Nelumbinis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, kidney channel.Cure mainly: clearing away heart-fire for tranquillization, restoring normal coordination between the heart and kidney, unsmoothing the sperm and stopping bleeding.For heat attacking the pericardium, unconsciousness and delirium, disarmony between the heart and kidney, insomnia seminal emission, heat in blood is spitted blood.

Rhodobryum roseum Limpr.: nature and flavor: pungent, bitter is flat.Cure mainly: tranquilizing by nourishing the heart, liver heat removing and eyesight improving.For severe palpitation, neurasthenia; Conjunctival congestion and swelling pain is controlled in external.

Herba Cynomorii: source: come from " Amplification on Materia Medica addendum ".Nature and flavor: sweet in the mouth; Warm in nature.Gui Jing: return kidney; Liver; Large intestine channel.Cure mainly: kidney invigorating and YANG supporting; The relieving constipation of benefit intestinal.

Lignum Dalbergiae Odoriferae: nature and flavor: pungent, temperature.Gui Jing: return liver, spleen channel.Cure mainly: promoting flow of QI and blood, pain relieving, hemostasis.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.

Radix Angelicae Sinensis: sweet, bitter, pungent, warm.Enter the heart, liver, spleen channel.Enrich blood, invigorate blood circulation, regulating menstruation, moisturize, laxation.Cure mainly menoxenia, blood deficiency or blood stasis amenorrhea, dysmenorrhoea metrorrhagia, traumatic injury, ulcer sore pain, rheumatic arthralgia, blood deficiency such as just to close at the disease.

The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature, enters liver, spleen channel, joint venture of nourishing blood, easing the affected liver to relieve pain, and the effect of suppressing liver-YANG is mainly used in deficiecny of liver-YIN, the headache feeling of fullness in the head of excessive rising of liver-YANG, vertigo and tinnitus, irritable; Deficiency of liver-blood, battalion defends the menoxenia of inanition, metrorrhagia and metrostaxis; The dysmenorrhea of deficiency of the liver stasis dampness; Disharmony of nutrient QI with defensive QI, the cloudy outer inducing vomiting spontaneous sweating of battalion; The gastral cavity abdomen pain over the hypochondriac region of depression of liver-QI, dysentery is suffered from abdominal pain; Deficiency and exhaustion of liver-YIN, passages through which vital energy circulates loses the card such as carpopedal spasm pain of supporting, and paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.There are antithrombus formation and hepatoprotective effect, have inhibitory action to dysentery bacterium, Bacillus typhi, blood dissolubility streptococcus, Diplococcus pneumoniae, bacillus pyocyaneus, staphylococcus aureus.

Ramulus Cinnamomi: pungent, sweet, warm in nature; Enter bladder, the heart, lung meridian.Function diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.Expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.

Herba Asari: acrid in the mouth, warm in nature, mild toxicity.Lung meridian, kidney channel, heart channel, Liver Channel, gallbladder meridian, spleen channel.Induce sweat cold expelling; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention; The therapeutic method to keep the adverse QI flowing downwards is eliminated the phlegm, sensible.

Bulbus Allii Macrostemonis: acrid in the mouth, hardship, warm in nature; Gui Jing, lung, the heart, stomach, large intestine channel.Have and regulate the flow of vital energy, the chest stuffiness relieving, activate yang, eliminating stagnation, effect of intestinal stasis relieving.Cure mainly the thorough back of the body of obstruction of qi in the chest and cardialgia, breast gastral cavity painful abdominal mass is vexed, cough with asthma abundant expectoration, epigastric pain, heavy after letting out dysentery, leucorrhea, furuncle carbuncle.

Fructus Trichosanthis: nature and flavor are sweet, bitter, cold.Enter lung, stomach, large intestine channel.Clearing away heat and eliminating phlegm, the relieving constipation of lung moistening eliminating stagnation.Compendium of Material Medica is said: " lung moistening is dry, pathogenic fire reducing.Control cough, clearing away phlegm is tied, throat, subduing inflammation sore." " book on Chinese herbal medicine is just read " record: " and Fructus Trichosanthis, nature and flavor are identical with pollen, only the profit merits and demerits of falling it.Therefore all stagnation of heat in upper-JIAOs, the cards such as dirty greasy phlegm-fire cough, all can use it.The fiery person of genus of all lung abscess, acute appendicitis, acute mastitis, particularly suitable." function cures mainly: lung moistening, reduce phlegm, eliminating stagnation, intestine moistening.Control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle from the beginning of.

The Rhizoma Pinelliae: its acrid in the mouth, warm in nature, poisonous; Return spleen, stomach, lung meridian.Function drying dampness to eliminate phlegm, and middle stomach invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, external can reducing swelling and alleviating pain.

Semen Sinapis Albae: acrid in the mouth, temperature, nontoxic.Enter the warp of liver, spleen, lung, stomach, the heart and collaterals of the uterus.Can remove cold air, settling five organs, by the expectorant of film diaphragm, ward off stealthy gas, the addiction that disappears malaria, drop interests Dingchuan, sharp key improving eyesight, and removing blood stasis relieves the pain, and all can prove effective.Can energy dissipating fall, energy complementary energy liter, helps all tonics, outstanding kind receipts merit.

Ramulus Mori: bitter in the mouth, micro-pungent, property is put down.Return liver, lung meridian.Clearing heat and expelling damp dredging collateral.For beriberoid pyretic arthralgia, extremities joint pain.Cure mainly rheumatic Bi syndrome, and be especially suitable for upper limb arthralgia pain.Effect: wind-damp dispelling, sharp joint, row aqueous vapor.Cure mainly: control anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen.Meridian distribution of property and flavor:: micro-hardship; Property is put down.1. " Bencao Tujing ": flat.2. " detailed outline ": bitter, flat.3. " medical center bun is wanted ": Gan Xin, flat.4. " book on Chinese herbal medicine is new again ": taste is poor, is slightly cold, nontoxic.Mulberry head: bitter in the mouth, cold in nature, nontoxic.Meridian distribution of property and flavor: enter Liver Channel.1. " book on Chinese herbal medicine must be joined ": enter meridian of Hand-TAI YIN.' 2. " book on Chinese herbal medicine is new again ": enter lung, kidney two warp.3. " book on Chinese herbal medicine brief points ": to start with, meridian of Foot-TAI YIN.Effect and effect: wind-damp dispelling; The meridian dredging; Row aqueous vapor.Main air pain of dampness syndrome; Apoplexy and hemiplegia; Edema foot gas; Human body pruritus due to wind pathogen.For takeing on arm, joint aches is numb.1. " Bencao Tujing ": treat all over body pruritus due to wind pathogen dry, beriberi pathogenic wind, spasm of the limbs, upper gas, feels dizzy, and lung qi is coughed, and helps digestion; Diuresis, holds concurrently and treats xerostomia.2. " book on Chinese herbal medicine covers bamboo fish trap ": profit breathes heavily inverse gas ， Xiao burning swelling poison carbuncle of coughing.3. " book on Chinese herbal medicine converges and says ": remove pathogenic wind spasm and pain.4. essentials of Matea Medica: sharp joint, promoting fluid production, row water dispels the wind.5. " beautiful Chinese catalpa medicine solution ": control apoplexy crooked, cough.6. " book on Chinese herbal medicine is new again ": strong lung qi, dampness, kidney nourishing water, stimulates the menstrual flow, cough-relieving relieving restlessness, reducing swelling and alleviating pain.7. " south of the Five Ridges gather medicinal herbs record ": joint wind disease of boning, punish-old year the arthroncus of knee.8. " modern Practical Chinese medicinal ": twig and leaf endure cream clothes, control hypertension, numb hand and foot.

Rhizoma Curcumae Longae: acrid in the mouth, hardship, warm in nature, return liver, spleen channel, there is removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia.For amenorrhea due to stagnation of blood, menalgia, the breast side of body twinges, rheumatic arthralgia, shoulder arm pain, the cards such as injury from falling down.Compendium of Material Medica: " Rhizoma Curcumae Longae, time near with flat if Rhizoma Zingiberis shape person is for RHIZOMA WENYUJIN CONCISA, circle such as Cicadae abdomen shape person be Cicadae tripe Radix Curcumae, though and the ， Shu shape seemingly Radix Curcumae of dyeing that can soak, complexion is not yellow yet." " book on Chinese herbal medicine asks former ": " and Rhizoma Curcumae Longae, benefit fire is angry, this cremate gas of pungent temperature, and gas biochemistry then body fluid is capable of three YIN and three YANG; Clear person notes in lung, turbid person note in through, slip in sea, and blood is voluntarily, is the eliminating stagnation and doublely let out blood also of regulating the flow of vital energy." there is removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia.For amenorrhea due to stagnation of blood, menalgia, the breast side of body twinges, rheumatic arthralgia, shoulder arm pain, the cards such as injury from falling down.Carry out tissue culture and experiments in vivo with Mus DaltonShi lymphoid ascites oncocyte, curcumol extract energy anticancer grows.Rhizoma Curcumae Longae extract, curcumin, volatile oil, turmerone and zingiberene, Borneolum Syntheticum and sesquiterpenoid etc., have choleretic effect, can increase generation and the secretion of bile, and can promote gallbladder contraction, and the strongest with acting as of curcumin.

Cortex Cinnamomi: nature and flavor are pungent, sweet, hot greatly.Return kidney, spleen, the heart, Liver Channel.There is complement sun, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation.Can control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower." Japan hanako materia medica ": control all pathogenic wind, mends five kinds of strain and seven kinds of impairment, logical nine orifices, sharp joint, benefit essence, improving eyesight, warm waist knee joint, and broken mass beside the umbilicus lump in the abdomen, repercussive blood, controls migratory arthralgia joint contracture, reuniting the fractured tendons and bones, granulation promoting meat.Detailed outline ": control arthralgia due to cold, wind Dumb, excess of YIN is lost blood, dysentery, diarrhea induced by fright.Control yang deficiency to lose blood, expelling the toxic substance from the body with tonic carbuncle variola, blood antiperspirant can be drawn and suppurate, separate Serpentis Pallas pit viper poison.There is complement sun, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation.Can control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.

The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Air making-up and spleen enlivening, benefit defends real table, ascending up spleen-Qi and Yang, poison holding sore, inducing diuresis to remove edema.Essentials of Matea Medica: " Radix Astragali, life consolidating superficial resistance losslessly can be sent out, and have antiperspirant to stop; Process with invigorating middle warmer, beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.

Rhizoma Atractylodis Macrocephalae (parched): sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cure mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, has regulating action to gastrointestinal function.

Os Draconis (calcined): sweet puckery is flat; Enter the heart, liver, kidney, large intestine channel.Function tranquillization with heavy prescription tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time." property of medicine opinion ": " by pathogen, tranquilizing mind, only cold-dysentery and defecation with blood and pus, woman's metrorrhagia leukorrhagia, only dream lets out essence, sexual intercourse in dream, controls hematuria, empty and dreaminess diverse and confused adding and use it."

Fructus Aurantii: bitter, acrid, cold, returns spleen, stomach, liver, the heart three warp.Dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.1. " property of medicine opinion ": control rubella all over, dislike and itch, main hemorrhoidal hamorrhage haemorrhoids, stagnation of QI in chest and abdomen in flesh as numb bean, the swollen void of two sides of body, pass diaphragm is congested.2. " Japan hanako materia medica ": spleen benefiting and stimulating the appetite, adjust the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, preventing or arresting vomiting is inverse, expectorant.Control regurgitation, cholera dysentery, helps digestion, and broken crux mass beside the umbilicus, five types of dysphagia, except wind improving eyesight and lung qi edema, sharp intestine and small intestine, skin is itched.Swollen can the processing of hemorrhoid is pressed.3. " Kaibao Bencao ": main air is itched paralysis, easing joint movement, consumptive disease is coughed, and back of the body arm is bored and listless, loosely stays knot, chest and diaphragm expectorant stagnant, and relieve oedema or abdominal distension through diuresis or purgation, full, the large hemorrhoidal hamorrhage of relieving distension, peace stomach, only wind bitterly.4. " pearl sac ": dispelling the stagnated QI, gas unfavorable in lung is let out.5. " medicine origin ": " curing mainly secret formula " cloud, broken hardness in the epigastrium painful abdominal mass, profit is gas in the heart, reduces phlegm, and 6. help digestion " detailed outline ": control tenesmus.

Semen Arecae: bitter in the mouth, pungent, warm in nature.Return stomach, large intestine channel.Have parasite killing, removing mass, sending down the abnormal ascending QI is capable stagnant, and row aquation wets.Effect.Cure mainly rapid digestion of food to relieve oedema or abdominal distension through diuresis or purgation, kill intestinal volt corpse, proglottid of tapeworm; Except dampness, get round by bribery, sharp nine orifices, relieving restlessness, caking in broken abdomen; Also can control beriberi, edema, chest pain, dysentery, abdominal distention is suffered from abdominal pain, defecation is unfavorable, mental disorder dyspnea with rapid respiration, treat pernicious malaria, resist communicable subtropical diseases.

Semen Platycladi: sweet is flat.GUIXIN, kidney, large intestine channel.Tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For restlessness of asrhenia type and insomnia, severe palpitation, the diseases such as dryness of the intestine constipation.Shennong's Herbal: " cypress is real, and sweet in the mouth is put down, and main palpitation with fear, settling five organs, QI invigorating, except rheumatism numbness, clothes of a specified duration make us moist, beauty, normal hearing and eyesight." Compendium of Material Medica: " nourish heart gas, and profit kidney is dry, and peace soul determines soul, and Fructus Alpiniae Oxyphyllae is allayed excitement.”

Rhizoma Et Radix Notopterygii: acrid in the mouth, bitter, warm in nature; Enter bladder, kidney channel.Function is fallen apart exterior cold, wind-damp dispelling, sharp joint, pain relieving.Main affection of exogenous wind-cold, has a headache lossless, edema due to wind pathogen edema, sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.Induce sweat cold expelling, expelling wind and dampness, pain relieving." property of medicine opinion ": " control harmful wind, aphonia in silence, blood leprosy of itching, hands and feet caused by paralysis, the askew heresy of actinal surface, insensitive impediment all over more." " product remittance essence is wanted ": " main all joints being painful all over, flesh table eight winds coming from eight orientations harmful climatic factors, except new and old rheumatism, row's slough cellulitis skin ulcer." " Thunder God concoct the property of medicine solution ": " Rhizoma Et Radix Notopterygii gas belongs to clearly sun, benefaction edema caused by disorder of QI, relaxes and does not hold back, and rises and can sink, male and be apt to fall apart, and can deliver heresy, therefore sun small intestinal of starting with.Foot sun bladder is to manage urticaria, though if its function is different from Radix Angelicae Pubescentis, reality is the exterior and the interior mutually." function falls apart exterior cold, wind-damp dispelling, sharp joint, pain relieving.

Massa Medicata Fermentata: nature and flavor are bitter, temperature.Strengthening the spleen to promote digestion, regulating QI to expel dampness, induces sweat.1. " property of medicine is examined ": " micro-bitter fragrant sweet." 2. " detailed outline is picked up any lost article from the road ": " and sweet light, delicate fragrance." enter spleen, stomach, large intestine channel.After flour, wheat bran and multi-medicament are mixed, through the herbal leaven of fermentation.Can strengthening the spleen to promote digestion, regulating QI to expel dampness, induces sweat.Cure the wound the food feeling of stuffiness in chest, and stomachache is vomited and diarrhoea, dysentery, headache due to common cold, and children's hinders hungry mistake and satisfies.Yeast is had in Massa Medicata Fermentata.Its composition has volatile oil, glycoside, fatty oil and vitamin B etc." Bencao Jingshu " is said: " ancients are bent, the song namely brewed alcoholic beverages, the sweet temperature of its abnormal smells from the patient, the special food stagnation removing of property, the stagnant gas of row taste, and loose internal organs are air-cooled.Massa Medicata Fermentata is that descendant specially makes, and with hyoscine, doubles in distillers yeast ".

Semen Oroxyli: bitter in the mouth, acid, cold nature, enters liver, spleen channel, joint venture of nourishing blood, easing the affected liver to relieve pain, and the effect of suppressing liver-YANG is mainly used in deficiecny of liver-YIN, the headache feeling of fullness in the head of excessive rising of liver-YANG, vertigo and tinnitus, irritable; Deficiency of liver-blood, battalion defends the menoxenia of inanition, metrorrhagia and metrostaxis; The dysmenorrhea of deficiency of the liver stasis dampness; Disharmony of nutrient QI with defensive QI, the cloudy outer inducing vomiting spontaneous sweating of battalion; The gastral cavity abdomen pain over the hypochondriac region of depression of liver-QI, dysentery is suffered from abdominal pain; Deficiency and exhaustion of liver-YIN, passages through which vital energy circulates loses the cards such as the carpopedal spasm pain of supporting.

Embodiment 1 injectable powder

The manufacturing process of injectable powder of the present invention is: get Radix Angelicae Sinensis 250g, Lignum Dalbergiae Odoriferae 170g, Radix Paeoniae Alba 300g, Herba Cynomorii 200g, Ramulus Cinnamomi 150g, Rhodobryum roseum Limpr. 170g, Herba Asari 120g, Plumula Nelumbinis 320g, Bulbus Allii Macrostemonis 240g, Fructus Trichosanthis 200g, Fructus Psoraleae 300g, Rhizoma Pinelliae 30g, Fluoritum 250g, Semen Sinapis Albae 150g, Radix Ophiopogonis 200g, Ramulus Mori 320g, Radix Lamiophlomidis Rotatae 30g, Rhizoma Curcumae Longae 330g, Radix Rubiae 200g, Cortex Cinnamomi 350g, Fructus Tritici Levis 260g, Radix Astragali 150g, Radix Codonopsis 220g, Rhizoma Atractylodis Macrocephalae (parched) 300g, Herba Oenanthes Javanicae 250g, Os Draconis (calcined) 350g, Radix Cinnamomi Camphorae 240g, Fructus Aurantii 340g, Flos Magnoliae Officinalis 120g, Semen Arecae 170g, Semen pini koraiensis 280g, Semen Platycladi 150g, Semen Aesculi 240g, Rhizoma Et Radix Notopterygii 160g, Herba Olgaeae leucophyllae 350g, Massa Medicata Fermentata 200g, pick up the ears 190g and Semen Oroxyli 120g,

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 32 hours under the condition of 7 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 0.7 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 2 oral liquid

The manufacturing process of oral liquid of the present invention is: get Radix Angelicae Sinensis 350g, Lignum Dalbergiae Odoriferae 220g, Radix Paeoniae Alba 300g, Herba Cynomorii 240g, Ramulus Cinnamomi 330g, Rhodobryum roseum Limpr. 200g, Herba Asari 320g, Plumula Nelumbinis 130g, Bulbus Allii Macrostemonis 250g, Fructus Trichosanthis 220g, Fructus Psoraleae 300g, Rhizoma Pinelliae 30g, Fluoritum 200g, Semen Sinapis Albae 150g, Radix Ophiopogonis 220g, Ramulus Mori 320g, Radix Lamiophlomidis Rotatae 30g, Rhizoma Curcumae Longae 350g, Radix Rubiae 200g, Cortex Cinnamomi 330g, Fructus Tritici Levis 140g, Radix Astragali 200g, Radix Codonopsis 150g, Rhizoma Atractylodis Macrocephalae (parched) 330g, Herba Oenanthes Javanicae 220g, Os Draconis (calcined) 350g, Radix Cinnamomi Camphorae 240g, Fructus Aurantii 340g, Flos Magnoliae Officinalis 200g, Semen Arecae 250g, Semen pini koraiensis 150g, Semen Platycladi 300g, Semen Aesculi 220g, Rhizoma Et Radix Notopterygii 140g, Herba Olgaeae leucophyllae 350g, Massa Medicata Fermentata 170g, pick up the ears 250g and Semen Oroxyli 150g,

The first step, by Radix Cinnamomi Camphorae, Fructus Aurantii, Flos Magnoliae Officinalis, Semen Arecae, Semen pini koraiensis, Semen Platycladi, Semen Aesculi, Rhizoma Et Radix Notopterygii, Herba Olgaeae leucophyllae, Massa Medicata Fermentata, pick up the ears and Semen Oroxyli mixing, add relative to mixture 7 times amount determining alcohol be 90% alcohol reflux 2 times, each 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.38, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 6 times of water gagings, boils 5 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.35;

3rd step, the described mastic mixing that the first step, second step are obtained, 80 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 48 hours, and refrigerated storage temperature is 5 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.22; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.004; The time of described heat treated is 80 minutes, and temperature is 180 DEG C;

Embodiment 3 tablet

The manufacturing process of Tablets is: get Radix Angelicae Sinensis 150g, Lignum Dalbergiae Odoriferae 220g, Radix Paeoniae Alba 300g, Herba Cynomorii 320g, Ramulus Cinnamomi 200g, Rhodobryum roseum Limpr. 150g, Herba Asari 320g, Plumula Nelumbinis 220g, Bulbus Allii Macrostemonis 150g, Fructus Trichosanthis 220g, Fructus Psoraleae 300g, Rhizoma Pinelliae 30g, Fluoritum 150g, Semen Sinapis Albae 200g, Radix Ophiopogonis 280g, Ramulus Mori 320g, Radix Lamiophlomidis Rotatae 30g, Rhizoma Curcumae Longae 250g, Radix Rubiae 200g, Cortex Cinnamomi 330g, Fructus Tritici Levis 140g, Radix Astragali 200g, Radix Codonopsis 140g, Rhizoma Atractylodis Macrocephalae (parched) 320g, Herba Oenanthes Javanicae 240g, Os Draconis (calcined) 350g, Radix Cinnamomi Camphorae 240g, Fructus Aurantii 320g, Flos Magnoliae Officinalis 200g, Semen Arecae 150g, Semen pini koraiensis 240g, Semen Platycladi 300g, Semen Aesculi 250g, Rhizoma Et Radix Notopterygii 140g, Herba Olgaeae leucophyllae 320g, Massa Medicata Fermentata 200g, pick up the ears 320g and Semen Oroxyli 200g,

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 3 hours, pulverize, sieve, obtain 500 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.15 times, 0.3 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.04 times of magnesium stearate, granulate, tabletting, makes.

Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 25g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 3 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: by the Oral Liquid On Mice of the embodiment of the present invention 2 by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Injection toxicity test:

(1) animal is selected

Cleaning grade kunming mice 40, male and female half and half, body weight 18 ~ 22 g; Laboratory observation 1 week, before each administration, fasting 4 h, can't help water.

(2) test grouping

By above cleaning grade kunming mice laboratory observation 1 week, the cleaning grade kunming mice of clinical observation result health is divided into two groups at random, often organizes 20 (male and female half and half).Wherein one group is set as experimental group, and another group is set as matched group.

(3) medication and dosage

Mouse tail vein injection, experimental group is with successive administration in maximum (former) concentration of the embodiment of the present invention 1 and maximum volume 24 h 3 times, give 0.6 ml/20g(Mouse Weight) medicine, i.e. the injection 1.8g(crude drug amount of mouse tail vein injection embodiment 1 in 24 h)/20g(Mouse Weight); Matched group is to the injection normal saline of same volume.

(4) observational technique and index

Weigh the weight of animals before administration and observe feed intake and drinking-water situation; After administration, every day weighs the weight of animals, feed intake and undue toxicity's symptom at same time, Continuous Observation 14 d.Observation index is as follows: 1. take action, as unease, many dynamic, sounding; 2. nervous system reaction, as lifted tail, chatter, spasm, movement disorder, attitude extremely; 3. autonomic nervous system reaction, as exophthalmos, sialorrhea, shed tears, urinate, drop, perpendicular hair, dyschromasia, adnormal respiration; 4. drinking-water and appetite change, defecation and color thereof, nose, eye, oral cavity whether with or without abnormal secretion thing, body weight change; 5. death condition.

(5) experimental result

By the observation of 14 d, two groups all do not have undue toxicity to react appearance, do not occur yet animal dead phenomenon.Therefore, the injection of the embodiment of the present invention 1 has no side effect.

Clinical data:

Case selection: fetch and come from the court's period 308 routine expectorant in July ,-2012 in July, 2011 turbid impatency type patients with coronary heart disease, wherein man 161 example, female 147 example; 42 ~ 75 years old age, 60.7 ± 2.3 years old mean age, myocardial infarction 97 example, angina pectoris 112 example, arrhythmia, cardiac blood supply deficiency 99 example, all cases is all made a definite diagnosis through resting electrocardiogram, exercise stress electrocardiogram and 24 hr Ambulatory EKG Monitoring, CT, coronary angiography inspection.308 routine patients are divided into injectable powder treatment group, oral liquid treatment group, tablet in treatment group and matched group at random, and each experimental group 77 people, each experimental group is at age, sex difference not statistically significant.

Diagnostic criteria:

1, myocardial infarction: it is the evolution row current of injury occurring exception, lasting Q ripple or QS ripple and continue more than 1 day that Electrocardiographic certainty changes.

2, angina pectoris: angina pectoris, tranquillization electrograph is about more than half can be normal, leading based on R ripple during angina pectoris attacks, can occur that ST section level or sagging type force down, companion or without T ripple, smooth, two-way or be inverted, variant angina pectoris outbreak time visible ST section high, to have an electro-cardiogram if desired stress test, radionuclide myocardial development and coronarography.

3, arrhythmia, cardiac blood supply deficiency: comprise premature beat electrocardiogram, paroxysmal supraventricular tachycardia, atrial fibrillation, slow arrhythmia electrocardiogram, cardiac blood supply deficiency electrocardiogram.

Refer again to " Diagnostics of Chinese Medicine ", " TCM syndrome Differential Diagnosis ", primary symptom: uncomfortable in chest and double pained time do, expectorant glues the white greasy band of tongue to be done, or yellowish greasy, if expectorant is thick, color or Huang, defecate partially dry, greasy fur or dry, or yellow greasy, be then that expectorant is warm.Hope according to the traditional Chinese medical science, hear, ask, cut and be diagnosed as expectorant turbid impatency type coronary heart disease further.

Therapeutic Method: in medication therapy groups:

Injectable powder treatment group: use injectable powder intravenous drip prepared by the embodiment of the present invention 1, fully dissolving with appropriate water for injection, then dilute with 5% glucose injection 500ml, every day 1 time, each per kilogram of body weight 30mg, every 30 days is 1 course for the treatment of;

Oral liquid treatment group: use oral liquid prepared by the embodiment of the present invention 2, every day 3 times, 30ml/ time every 30 days is a course for the treatment of;

Tablet in treatment group: take the embodiment of the present invention 3 prepare tablet, every day 3 times, one time 2, within every 30 days, be a course for the treatment of.

Matched group: take vibration source capsule, every day 3 times, 2 tablets/time every 30 days is a course for the treatment of.

The standard of curative effect evaluation:

1, myocardial infarction:

Cure: normal ECG, without any clinical symptoms, follow the tracks of 3-7 and have no recurrence;

Effective: normal ECG, without any clinical symptoms, in 3 years, there is rebound phenomena;

Take a turn for the better: electrocardiogram takes a turn for the better, and symptom obviously alleviates;

Invalid: electrocardiogram is without change, but symptom alleviates.

2, angina pectoris:

Invalid: electrocardiogram is without change, but symptom alleviates.

3, arrhythmia, cardiac blood supply deficiency:

Invalid: electrocardiogram is without change, but symptom alleviates.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy expectorant of the present invention turbid impatency type coronary heart disease, relative to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy expectorant of the present invention turbid impatency type coronary heart disease, relative to conventional medicament, treatment the course for the treatment of on significantly shorten.

After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine

Group	Number of cases	Cure number	Effective number	Good revolution	Invalid number	Total effective rate (%)
							Injectable powder treatment group	77	34	37	6	0	100％
Oral liquid treatment group	77	35	38	4	0	100％
							Tablet in treatment treatment group	77	33	35	8	1	98.7％
Matched group	77	15	20	27	15	80.5％

Table 2 Four composition do not treat after 4 courses for the treatment of cure, effective and improvement number and time comparative example (%)

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of	4th course for the treatment of
						Injectable powder treatment group	77	16（20.8％）	19（24.7％）	20（30％）	22（28.6％）
Oral liquid treatment group	77	17（22.1％）	18（23.4％）	19（24.7％）	23（29.9％）
						Tablet in treatment treatment group	76	16（21.1％）	18（23.7％）	20（26.3％）	22（28.9％）
Matched group	62	6（9.7％）	8（12.9％）	9（14.5％）	39（62.9％）

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; Treatment group is cured simultaneously, 230 examples of effective and improvement number and matched group is cured, the effective and 62 routine follow-up of patients 1 year half that takes a turn for the better, result is added up, in injectable powder treatment group 77 example, healing 34 example and effective 37 examples are all without recurrence, 1 case relapsed in 6 examples of improvement, and relapse rate is 1.3%; In oral liquid treatment group 77 example, 4 examples of healing 35 example, effective 38 examples, improvement are all without recurring, and relapse rate is 0%; Cure 33 examples in tablet in treatment group 76 example without recurrence, 1 case relapsed in effective 35 examples, recur 2 examples in 8 examples of improvement, relapse rate is 3.9%; Matched group is cured, effective and improvement number 62 example, recurs 6 examples, recurs 8 examples in effective 20 routine patients, recur 11 examples, relapse rate 40.3% in 27 examples of improvement in 15 routine patients of healing; Above-mentioned recurrence refers to that patient outcomes reaches healing, effective or after taking a turn for the better, do not occur uncomfortable in chest at 1 year half septum reset of following up a case by regular visits to, expectorant glues the white greasy band of tongue to be done, and yellowish greasy, if expectorant is thick, yellow skin, defecates partially dry, yellow greasy, be then the situations such as expectorant heat.

Model case: Lee, male, 57 years old, the precordialgia, two months uncomfortable in chest, in addition also with cardiopalmus, breathe hard, the symptom such as spontaneous perspiration, through electrocardiogram check result be, paroxysmal supraventricular tachycardia, atrial fibrillation, slow arrhythmia electrocardiogram, cardiac blood supply deficiency electrocardiogram, tentatively be diagnosed as coronary heart disease, hope through trial inspection and the traditional Chinese medical science, hear, ask, cut and be diagnosed as expectorant turbid impatency type coronary heart disease further.Use injectable powder intravenous drip prepared by Medications Example 1 of the present invention, medication first quarter moon is cured substantially, continues medication and cures a course for the treatment of, follow up a case by regular visits to and do not recur for 1 year half.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the medicine of expectorant turbid impatency type coronary heart disease for one kind, it is characterized in that, comprise following raw medicinal material: Radix Angelicae Sinensis, Lignum Dalbergiae Odoriferae, the Radix Paeoniae Alba, Herba Cynomorii, Ramulus Cinnamomi, Rhodobryum roseum Limpr., Herba Asari, Plumula Nelumbinis, Bulbus Allii Macrostemonis, Fructus Trichosanthis, Fructus Psoraleae, the Rhizoma Pinelliae, Fluoritum, Semen Sinapis Albae, Radix Ophiopogonis, Ramulus Mori, Radix Lamiophlomidis Rotatae, Rhizoma Curcumae Longae, Radix Rubiae, Cortex Cinnamomi, Fructus Tritici Levis, the Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Herba Oenanthes Javanicae, Os Draconis (calcined), Radix Cinnamomi Camphorae, Fructus Aurantii, Flos Magnoliae Officinalis, Semen Arecae, Semen pini koraiensis, Semen Platycladi, Semen Aesculi, Rhizoma Et Radix Notopterygii, Herba Olgaeae leucophyllae, Massa Medicata Fermentata, to pick up the ears and Semen Oroxyli.

2. the medicine for the treatment of expectorant according to claim 1 turbid impatency type coronary heart disease, is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 15 ~ 35 parts, Lignum Dalbergiae Odoriferae 12 ~ 22 parts, the Radix Paeoniae Alba 11 ~ 31 parts, Herba Cynomorii 14 ~ 34 parts, Ramulus Cinnamomi 15 ~ 35 parts, Rhodobryum roseum Limpr. 12 ~ 20 parts, Herba Asari 10 ~ 32 parts, Plumula Nelumbinis 13 ~ 33 parts, Bulbus Allii Macrostemonis 14 ~ 28 parts, Fructus Trichosanthis 15 ~ 25 parts, Fructus Psoraleae 12 ~ 30 parts, the Rhizoma Pinelliae 3 ~ 5 parts, Fluoritum 12 ~ 32 parts, Semen Sinapis Albae 11 ~ 21 parts, Radix Ophiopogonis 13 ~ 27 parts, Ramulus Mori 13 ~ 32 parts, Radix Lamiophlomidis Rotatae 3 ~ 5 parts, 15 ~ 35 parts, Rhizoma Curcumae Longae, 12 ~ 20 parts, Radix Rubiae, Cortex Cinnamomi 15 ~ 35 parts, Fructus Tritici Levis 10 ~ 30 parts, the Radix Astragali 10 ~ 20 parts, Radix Codonopsis 12 ~ 28 parts, Rhizoma Atractylodis Macrocephalae (parched) 14 ~ 34 parts, Herba Oenanthes Javanicae 12 ~ 26 parts, Os Draconis (calcined) 15 ~ 35 parts, Radix Cinnamomi Camphorae 14 ~ 28 parts, Fructus Aurantii 16 ~ 36 parts, Flos Magnoliae Officinalis 10 ~ 20 parts, Semen Arecae 15 ~ 25 parts, Semen pini koraiensis 14 ~ 28 parts, Semen Platycladi 13 ~ 30 parts, Semen Aesculi 15 ~ 25 parts, Rhizoma Et Radix Notopterygii 10 ~ 20 parts, Herba Olgaeae leucophyllae 15 ~ 35 parts, Massa Medicata Fermentata 13 ~ 23 parts, to pick up the ears 14 ~ 32 parts and Semen Oroxyli 10 ~ 20 parts.

3. the medicine for the treatment of expectorant according to claim 1 and 2 turbid impatency type coronary heart disease, is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 15 ~ 35 parts, Lignum Dalbergiae Odoriferae 14 ~ 22 parts, the Radix Paeoniae Alba 13 ~ 30 parts, Herba Cynomorii 15 ~ 34 parts, Ramulus Cinnamomi 15 ~ 35 parts, Rhodobryum roseum Limpr. 14 ~ 20 parts, Herba Asari 12 ~ 32 parts, Plumula Nelumbinis 13 ~ 32 parts, Bulbus Allii Macrostemonis 14 ~ 25 parts, Fructus Trichosanthis 15 ~ 22 parts, Fructus Psoraleae 14 ~ 30 parts, the Rhizoma Pinelliae 3 ~ 5 parts, Fluoritum 13 ~ 30 parts, Semen Sinapis Albae 12 ~ 20 parts, Radix Ophiopogonis 14 ~ 28 parts, Ramulus Mori 15 ~ 32 parts, Radix Lamiophlomidis Rotatae 3 ~ 5 parts, 15 ~ 35 parts, Rhizoma Curcumae Longae, 15 ~ 20 parts, Radix Rubiae, Cortex Cinnamomi 15 ~ 35 parts, Fructus Tritici Levis 12 ~ 30 parts, the Radix Astragali 14 ~ 20 parts, Radix Codonopsis 12 ~ 25 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 ~ 33 parts, Herba Oenanthes Javanicae 15 ~ 25 parts, Os Draconis (calcined) 15 ~ 35 parts, Radix Cinnamomi Camphorae 14 ~ 26 parts, Fructus Aurantii 16 ~ 34 parts, Flos Magnoliae Officinalis 12 ~ 20 parts, Semen Arecae 15 ~ 25 parts, Semen pini koraiensis 15 ~ 28 parts, Semen Platycladi 15 ~ 30 parts, Semen Aesculi 15 ~ 25 parts, Rhizoma Et Radix Notopterygii 12 ~ 20 parts, Herba Olgaeae leucophyllae 15 ~ 35 parts, Massa Medicata Fermentata 15 ~ 20 parts, to pick up the ears 15 ~ 32 parts and Semen Oroxyli 10 ~ 20 parts.

4. the medicine of the treatment expectorant turbid impatency type coronary heart disease according to any one of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 25 parts, Lignum Dalbergiae Odoriferae 17 parts, the Radix Paeoniae Alba 30 parts, Herba Cynomorii 20 parts, Ramulus Cinnamomi 15 parts, Rhodobryum roseum Limpr. 17 parts, Herba Asari 12 parts, Plumula Nelumbinis 32 parts, Bulbus Allii Macrostemonis 24 parts, Fructus Trichosanthis 20 parts, Fructus Psoraleae 30 parts, the Rhizoma Pinelliae 3 parts, Fluoritum 25 parts, Semen Sinapis Albae 15 parts, Radix Ophiopogonis 20 parts, Ramulus Mori 32 parts, Radix Lamiophlomidis Rotatae 3 parts, 33 parts, Rhizoma Curcumae Longae, 20 parts, Radix Rubiae, Cortex Cinnamomi 35 parts, Fructus Tritici Levis 26 parts, the Radix Astragali 15 parts, Radix Codonopsis 22 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 parts, Herba Oenanthes Javanicae 25 parts, Os Draconis (calcined) 35 parts, Radix Cinnamomi Camphorae 24 parts, Fructus Aurantii 34 parts, Flos Magnoliae Officinalis 12 parts, Semen Arecae 17 parts, Semen pini koraiensis 28 parts, Semen Platycladi 15 parts, Semen Aesculi 24 parts, Rhizoma Et Radix Notopterygii 16 parts, Herba Olgaeae leucophyllae 35 parts, Massa Medicata Fermentata 20 parts, to pick up the ears 19 parts and Semen Oroxyli 12 parts.

5. the medicine of the treatment expectorant turbid impatency type coronary heart disease according to any one of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 15 parts, Lignum Dalbergiae Odoriferae 22 parts, the Radix Paeoniae Alba 30 parts, Herba Cynomorii 32 parts, Ramulus Cinnamomi 20 parts, Rhodobryum roseum Limpr. 15 parts, Herba Asari 32 parts, Plumula Nelumbinis 22 parts, Bulbus Allii Macrostemonis 15 parts, Fructus Trichosanthis 22 parts, Fructus Psoraleae 30 parts, the Rhizoma Pinelliae 3 parts, Fluoritum 15 parts, Semen Sinapis Albae 20 parts, Radix Ophiopogonis 28 parts, Ramulus Mori 32 parts, Radix Lamiophlomidis Rotatae 3 parts, 25 parts, Rhizoma Curcumae Longae, 20 parts, Radix Rubiae, Cortex Cinnamomi 33 parts, Fructus Tritici Levis 14 parts, the Radix Astragali 20 parts, Radix Codonopsis 14 parts, Rhizoma Atractylodis Macrocephalae (parched) 32 parts, Herba Oenanthes Javanicae 24 parts, Os Draconis (calcined) 35 parts, Radix Cinnamomi Camphorae 24 parts, Fructus Aurantii 32 parts, Flos Magnoliae Officinalis 20 parts, Semen Arecae 15 parts, Semen pini koraiensis 24 parts, Semen Platycladi 30 parts, Semen Aesculi 25 parts, Rhizoma Et Radix Notopterygii 14 parts, Herba Olgaeae leucophyllae 32 parts, Massa Medicata Fermentata 20 parts, to pick up the ears 32 parts and Semen Oroxyli 20 parts.

6. the medicine of the treatment expectorant turbid impatency type coronary heart disease according to any one of claim 1-5, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 35 parts, Lignum Dalbergiae Odoriferae 22 parts, the Radix Paeoniae Alba 30 parts, Herba Cynomorii 24 parts, Ramulus Cinnamomi 33 parts, Rhodobryum roseum Limpr. 20 parts, Herba Asari 32 parts, Plumula Nelumbinis 13 parts, Bulbus Allii Macrostemonis 25 parts, Fructus Trichosanthis 22 parts, Fructus Psoraleae 30 parts, the Rhizoma Pinelliae 3 parts, Fluoritum 20 parts, Semen Sinapis Albae 15 parts, Radix Ophiopogonis 22 parts, Ramulus Mori 32 parts, Radix Lamiophlomidis Rotatae 3 parts, 35 parts, Rhizoma Curcumae Longae, 20 parts, Radix Rubiae, Cortex Cinnamomi 33 parts, Fructus Tritici Levis 14 parts, the Radix Astragali 20 parts, Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 33 parts, Herba Oenanthes Javanicae 22 parts, Os Draconis (calcined) 35 parts, Radix Cinnamomi Camphorae 24 parts, Fructus Aurantii 34 parts, Flos Magnoliae Officinalis 20 parts, Semen Arecae 25 parts, Semen pini koraiensis 15 parts, Semen Platycladi 30 parts, Semen Aesculi 22 parts, Rhizoma Et Radix Notopterygii 14 parts, Herba Olgaeae leucophyllae 35 parts, Massa Medicata Fermentata 17 parts, to pick up the ears 25 parts and Semen Oroxyli 15 parts.

7. the preparation method of the medicine of the treatment expectorant turbid impatency type coronary heart disease according to any one of claim 1-6, it is characterized in that, when the dosage form of described medicine is injectable powder, its preparation method comprises the following steps:

8. the preparation method of the medicine of the treatment expectorant turbid impatency type coronary heart disease according to any one of claim 1-6, it is characterized in that, when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:

9. the preparation method of the medicine of the treatment expectorant turbid impatency type coronary heart disease according to any one of claim 1-6, it is characterized in that, when the dosage form of described medicine is tablet, its preparation method comprises the following steps: