CN1403149A - Medicines composition for treating chronic heart failure and its prepn - Google Patents
Medicines composition for treating chronic heart failure and its prepn Download PDFInfo
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Abstract
The present invention provides one composite medicine for treating chronic heart failure. The composite medicine has the functions of invigorating vital energy, dredging meridian, promoting blood circulation and diuresis. The medicine composition has 11 kinds of Chinese medicinal materials including astragalus root or white atractylodes rhizome, mankshood, ginseng or Dangshen, red sage, pepperweed seed, etc. The pharmacological test shows that the capsule of the present invention has obvious improving effects to heart failure of dog caused by Pentobarbital sodium.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of chronic heart failure, belong to the Chinese herbal and crude drugs preparations technical field, it is weary to be particularly useful for treating clinically deficiency of YANG QI, and the heart disease of blood stasis causing water retention type chronic heart failure also can be treated the heart failure of other type.
Background technology
The many differentiation by the sick development of primary cardiac of chronic heart failure causes, be common clinically critical illness, the disease characteristics are many based on void, and insufficiency of heart-QI is the primary pathologic basis of this disease, causes blood operation to be obstructed, cause in the blood clots absorbing and stagnate, blood stasis network resistance, " menstruation disorder then be a water " wet and stopped gathering and water occurs, so the patient of chronic heart failure shows as the heart, lung, spleen, the how dirty disease together of kidney more, especially based on deficiency of heart-YANG and kidney-YANG.At present, both at home and abroad the used Western medicine of heart failure treatment is mainly contained three classes, one, the heart tonifying glycoside, be mainly used in congestive heart failure, but easily cause poisoning therapeutic dose under, bring out toxic and side effects such as ventricular premature contraction, bradycardia in addition; Two, vasodilation class, be mainly used to blood vessel dilating, load before and after alleviating heart, reduce the heart energy consumption and improve the hemodynamics of heart failure with indirect heart tonifying, but its narrow application range, easily produce sudden hypotension, bring out toxic and side effects such as the low disease of first, metahemoglobin disease, muscular tremor, disturbance of consciousness, lupoid acne syndrome, even the cyanogen lethal danger of poisoning also can take place; Three, amrinone, DOPA powder butylamine class cardiac tonic, they mainly are positive inotropic, reduction peripheral vascular resistance, lightening heart load, the enhancing heart blood discharge amounts that strengthens heart, but also have the toxic and side effects that can cause the platelet purpura, bring out rhythm of the heart quickening.Pure Chinese medicinal preparation discloses " a kind of manufacture method of Chinese medicine JIUXIN DAN " as CN1065793A, though this medicine has certain curative effect to heart failure, its primary symptom is not a heart failure, does not have the purpose for the treatment of both the principal and secondary aspects of a disease.CN1054984C discloses " the cardiopathic medicine of a kind of treatment ", and what it was mainly treated is the caused heart failure of cardiac hypertrophy, and flavour of a drug are too many.The present invention is utilization network ens morbi treatment chronic heart failure, particularly light, moderate patients with heart failure is this characteristics with void, adopt the QI invigorating warming YANG, the blood stasis dispelling diuretic forms for Therapeutic Principle's prescription, through the strict pharmaceutical technology and the research of quality standard, as preparation in institute clinical practice for many years, and prove that it is to improving cardiac function, improve labour's tolerance degree good efficacy is arranged, can effectively alleviate breathe hard, symptom such as weak, palpitation and restlessness, oliguria edema, in the medication process, do not find obvious adverse reaction and toxic reaction.
Summary of the invention
The present invention inquires into the medicine of chronic heart failure with traditional Chinese medical science network ens morbi, and a kind of drug regimen of the compatibility of drugs with invigorating qi and dredging collateral, hot temperature collateral dredging, promoting blood circulation to remove obstruction in the collateral, diuretic collateral dredging is provided, and reaches to treating both the principal and secondary aspects of a disease.
Technical scheme of the present invention is achieved in that the pharmaceutical composition of this treatment chronic heart failure, and its composition comprises the Radix Astragali or Rhizoma Atractylodis Macrocephalae 150-450 part, Radix Aconiti Lateralis Preparata 40-120 part, Radix Ginseng or Radix Codonopsis 75-225 part, Radix Salviae Miltiorrhizae 75-225 part, Semen Lepidii (Semen Descurainiae) 50-150 part, Cortex Periplocae or CORTEX ACANTHOPANACIS 60-180 part, Rhizoma Alismatis 75-225 part, Rhizoma Polygonati Odorati 25-75 part, Ramulus Cinnamomi 30-90 part, Flos Carthami 30-90 part, Pericarpium Citri Reticulatae 25-75 part.
The pharmaceutical composition of described treatment chronic heart failure, the better ratio of its composition are 450 parts of the Radixs Astragali, 112.5 parts of Radix Aconiti Lateralis Preparatas, 225 parts of Radix Ginsengs, 225 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Lepidii (Semen Descurainiae)s, 180 parts of Cortex Periplocaes, 225 parts of Rhizoma Alismatis, 75 parts of Rhizoma Polygonati Odorati, 90 parts of Ramulus Cinnamomi, 90 parts on Flos Carthami, 75 parts of Pericarpium Citri Reticulataes.
The pharmaceutical composition of described treatment chronic heart failure, its form also can comprise clinically rationally the Radix Ophiopogonis of dosage, Fructus Lycii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Rhizoma Zingiberis, Semen Persicae, Herba Ephedrae (processing) Radix Stephaniae Tetrandrae, Radix Paeoniae wherein one or more.
The preparation of drug combination method of above-mentioned treatment chronic heart failure comprises:
(1), Radix Astragali 450g, Semen Lepidii (Semen Descurainiae) 150g, Rhizoma Alismatis 225g, Radix Ginseng 225g, Cortex Periplocae 180g, add 8 times of amount 70% alcohol reflux 2 times, 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters decompression filtrate recycling ethanol, be concentrated into relative density and be the clear paste of 1.25-1.30 (60 ℃ of heat are surveyed), standby;
(2), Ramulus Cinnamomi 90g, Pericarpium Citri Reticulatae 75g distillating extracting oil, the aqueous solution of carrying behind the oil filters, standby, residue adds 8 times of amounts of water again and decocted 1 hour, filters, and merges decocting liquid, and is standby;
(3), Radix Aconiti Lateralis Preparata 112.5g, Radix Salviae Miltiorrhizae 225g, Rhizoma Polygonati Odorati 75g, Flos Carthami 90g add 9 times of amount decoctions of water 2 times, each 2 hours.Merge extractive liquid,, filter, merge with Ramulus Cinnamomi, Pericarpium Citri Reticulatae decocting liquid in (2), being concentrated into relative density is 1.25-1.30 (60 ℃ of heat are surveyed) clear paste, add ethanol in the stirring, left standstill below 70%, 4 ℃ 24 hours to determining alcohol, filter, decompression filtrate recycling ethanol, being concentrated into relative density is 1.25-1.30 (60 ℃ of heat are surveyed) clear paste, mixes 65-70 ℃ of oven dry with the alcohol-extracted extract of (1);
(4), dried cream mixed powder becomes 100 order powder, adds 70% ethanol and granulates in right amount, sprays into Ramulus Cinnamomi, Pericarpium Citri Reticulatae volatile oil, mixing, encapsulated, make 1000, promptly.
The preparation of drug combination method of described treatment chronic heart failure is characterized in that the dried cream mixture that makes step (1), (2), (3) can be used for preparing clinically the base stock of oral formulations such as tablet, electuary, powder, oral liquid.
Pharmacological testing studies show that through Xiyuan Hospital, Chinese Medicine Academy of China, the present invention's (trade name is a heart tonifying power capsule) is to the experimental heart failure of the dog effect of having clear improvement due to the pentobarbital sodium, mainly showing as increases LVMCF, and rising LVSP and dp/dtmax, increase CO and BP, shorten R-dp/dtmax, reduce LVEDP, simultaneously obvious renal blood flow increasing.Normal administration group hemodynamics experimental result shows that heart tonifying power capsule can improve LVSP, and dp/dtmax, RBF and CO improve the normal dogs left side heart 9 Room work done and cardiac functions.Observe of the protective effect of heart tonifying power capsule to the experimental chronic heart failure of rabbit; the result shows for the rabbit chronic heart failure model that adopts the coarctation of aorta method to cause; the administration group can make LVEDP, BP, LVP, T ripple, chamber wall thickness and cardiac index have clear improvement, with model group more all have significant difference (P＜0.05-P＜0.01 〉.Observe the diuresis of heart tonifying power to rat, the result shows that heart tonifying power is significantly increased the rat urine amount and promotes Na in the urine
+, K
+, Cl
-Excretion.Mice normobaric hypoxia experimental result shows that heart tonifying power capsule can obviously prolong the anoxia in mice death time.Mouse swimming test is the result show, heart tonifying power capsule can obviously prolong mice low temperature swimming time.See Appendix.
The specific embodiment
Example below in conjunction with drug regimen of the present invention illustrates the specific embodiment of the present invention.
Embodiment 1:1, Radix Astragali 450g Radix Aconiti Lateralis Preparata 112.5g Radix Ginseng 225g Radix Salviae Miltiorrhizae 225g Semen Lepidii (Semen Descurainiae) 150g Cortex Periplocae 180g Rhizoma Alismatis 225g Flos Carthami 90g Rhizoma Polygonati Odorati 75g Pericarpium Citri Reticulatae 75g Ramulus Cinnamomi 90g preparation method:
(1), the Radix Astragali, Semen Lepidii (Semen Descurainiae), Rhizoma Alismatis, Radix Ginseng, Cortex Periplocae are proportionally added 8 times of amount 70% alcohol reflux 2 times, 3 hours for the first time, 2 hours for the second time, merge extractive liquid,, filter, decompression filtrate recycling ethanol is concentrated into relative density and is the clear paste of 1.25-1.30 (60 ℃ of heat are surveyed), and is standby;
(2), Ramulus Cinnamomi, Pericarpium Citri Reticulatae distillating extracting oil proportionally, the aqueous solution of carrying behind the oil filters, standby, residue adds 8 times of amounts of water again and decocted 1 hour, filters, and merges decocting liquid, and is standby;
(3), Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Flos Carthami add 9 times of amount decoctions of water 2 times, each 2 hours.Merge extractive liquid,, filter, merge with Ramulus Cinnamomi, Pericarpium Citri Reticulatae decocting liquid in (2), being concentrated into relative density is 1.25-1.30 (60 ℃ of heat are surveyed) clear paste, add ethanol in the stirring, left standstill below 70%, 4 ℃ 24 hours to determining alcohol, filter, decompression filtrate recycling ethanol, being concentrated into relative density is 1.25-1.30 (60 ℃ of heat are surveyed) clear paste, mixes 65-70 ℃ of oven dry with the alcohol-extracted extract of (1);
(4), dried cream mixed powder becomes 100 order powder, adds 70% ethanol and granulates in right amount, sprays into Ramulus Cinnamomi, Pericarpium Citri Reticulatae volatile oil, mixing, encapsulated, make 1000, promptly.Embodiment 2:
Radix Astragali 250g Radix Aconiti Lateralis Preparata 112.5g Radix Ginseng 450g Radix Salviae Miltiorrhizae 120g
Radix Stephaniae Tetrandrae 150g Cortex Periplocae 90g Poria 120g Flos Carthami 45g
Rhizoma Polygonati Odorati 75g Pericarpium Citri Reticulatae 75g Ramulus Cinnamomi 45g
Embodiment 3:
Radix Astragali 900g Radix Aconiti Lateralis Preparata 200g Radix Ginseng 125g Radix Salviae Miltiorrhizae 225g
Semen Lepidii (Semen Descurainiae) 150g Cortex Periplocae 350g Rhizoma Alismatis 225g Flos Carthami 90g
Radix Ophiopogonis 75g Pericarpium Citri Reticulatae 75g Radix Paeoniae 150g Ramulus Cinnamomi 180g
Embodiment 4:
Radix Astragali 450g Radix Aconiti Lateralis Preparata 112.5g Rhizoma Atractylodis Macrocephalae 225g Radix Salviae Miltiorrhizae 225g
Semen Lepidii (Semen Descurainiae) 150g Cortex Periplocae 180g Poria 225g Flos Carthami 90g
Rhizoma Polygonati Odorati 75g Pericarpium Citri Reticulatae 75g Ramulus Cinnamomi 90g
Embodiment 5:
Radix Codonopsis 450g Radix Aconiti Lateralis Preparata 112.5g Rhizoma Dioscoreae 225g Radix Salviae Miltiorrhizae 225g
Semen Lepidii (Semen Descurainiae) 150g Cortex Periplocae 180g Rhizoma Alismatis 225g Flos Carthami 90g
Rhizoma Polygonati Odorati 75g Pericarpium Citri Reticulatae 75g Ramulus Cinnamomi 90g
Embodiment 6:
Radix Astragali 450g Rhizoma Zingiberis 112.5g Rhizoma Atractylodis Macrocephalae 225g Radix Angelicae Sinensis 225g
Semen Lepidii (Semen Descurainiae) 150g Cortex Periplocae 180g Rhizoma Alismatis 225g Radix Paeoniae Rubra 90g
Rhizoma Polygonati Odorati 75g Pericarpium Citri Reticulatae 75g Ramulus Cinnamomi 90g
Embodiment 7:
Rhizoma Atractylodis Macrocephalae 450g Radix Aconiti Lateralis Preparata 112.5g Radix Ginseng 225g Radix Salviae Miltiorrhizae 225g
Semen Lepidii (Semen Descurainiae) 150g Cortex Periplocae 180g Rhizoma Alismatis 225g Radix Paeoniae Rubra 90g
Rhizoma Polygonati Odorati 75g Pericarpium Citri Reticulatae 75g Herba Asari 45g
Embodiment 8:
Radix Astragali 450g Radix Aconiti Lateralis Preparata 112.5g Radix Ginseng 225g Radix Salviae Miltiorrhizae 225g
Semen Lepidii (Semen Descurainiae) 150g CORTEX ACANTHOPANACIS 90g Rhizoma Alismatis 225g Flos Carthami 90g
Rhizoma Polygonati Odorati 75g Radix Glycyrrhizae 150g Ramulus Cinnamomi 90g Herba Taxilli 180g
Embodiment 9:
Radix Astragali 900g Radix Aconiti Lateralis Preparata 112.5g Rhizoma Atractylodis Macrocephalae 225g Radix Salviae Miltiorrhizae 225g
Semen Lepidii (Semen Descurainiae) 150g Cortex Periplocae 180g Rhizoma Alismatis 225g Semen Persicae 90g
Herba Ephedrae (processing) 75g Pericarpium Citri Reticulatae 75g Ramulus Cinnamomi 180g Radix Glycyrrhizae 150g
Embodiment 10:
Radix Astragali 450g Radix Aconiti Lateralis Preparata 112.5g Rhizoma Atractylodis Macrocephalae 225g Radix Salviae Miltiorrhizae 225g
Semen Lepidii (Semen Descurainiae) 150g Cortex Periplocae 180g Poria 225g Flos Carthami 90g
Rhizoma Polygonati Odorati 75g Pericarpium Citri Reticulatae 75g Ramulus Cinnamomi 90g Radix Glycyrrhizae 150g
Embodiment 11:
Radix Astragali 450g Radix Aconiti Lateralis Preparata 112.5g Rhizoma Atractylodis Macrocephalae 225g Radix Angelicae Sinensis 225g
Semen Lepidii (Semen Descurainiae) 150g CORTEX ACANTHOPANACIS 180g Poria 225g Radix Paeoniae 90g
Rhizoma Polygonati Odorati 75g Pericarpium Citri Reticulatae 75g Ramulus Cinnamomi 90g Radix Glycyrrhizae 150g
Embodiment 12:
Radix Astragali 250g Radix Aconiti Lateralis Preparata 112.5g Radix Ginseng 450g Radix Salviae Miltiorrhizae 225g
Radix Polygoni Multiflori 150g Fructus Lycii 90g Radix Rehmanniae Preparata 75g Flos Carthami 90g
Pericarpium Citri Reticulatae 75g Ramulus Cinnamomi 90g Semen Persicae 180g
The dried cream mixture that the preparation method of the foregoing description is made can be used for preparing clinically the base stock of oral formulations such as tablet, electuary, powder.The preparation method of embodiment 2-12 and embodiment 1 are basic identical.
Claims (5)
1, a kind of pharmaceutical composition for the treatment of chronic heart failure, its composition comprise the Radix Astragali or Rhizoma Atractylodis Macrocephalae 150-450 part, Radix Aconiti Lateralis Preparata 40-120 part, Radix Ginseng or Radix Codonopsis 75-225 part, Radix Salviae Miltiorrhizae 75-225 part, Semen Lepidii (Semen Descurainiae) 50-150 part, Cortex Periplocae or CORTEX ACANTHOPANACIS 60-180 part, Rhizoma Alismatis 75-225 part, Rhizoma Polygonati Odorati 25-75 part, Ramulus Cinnamomi 30-90 part, Flos Carthami 30-90 part, Pericarpium Citri Reticulatae 25-75 part.
2, the pharmaceutical composition of treatment chronic heart failure according to claim 1, its proportion of composing are 450 parts of the Radixs Astragali, 112.5 parts of Radix Aconiti Lateralis Preparatas, 225 parts of Radix Ginsengs, 225 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Lepidii (Semen Descurainiae)s, 180 parts of Cortex Periplocaes, 225 parts of Rhizoma Alismatis, 75 parts of Rhizoma Polygonati Odorati, 90 parts of Ramulus Cinnamomi, 90 parts on Flos Carthami, 75 parts of Pericarpium Citri Reticulataes.
3, the pharmaceutical composition of treatment chronic heart failure according to claim 1, its form also can comprise Radix Ophiopogonis, Fructus Lycii, Radix Angelicae Sinensis, Radix Stephaniae Tetrandrae, Radix Paeoniae, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Rhizoma Zingiberis, Semen Persicae, Herba Ephedrae (processing) wherein one or more.
4, the preparation of drug combination method of above-mentioned treatment chronic heart failure comprises:
(1), Radix Astragali 450g, Semen Lepidii (Semen Descurainiae) 150g, Rhizoma Alismatis 225g, Radix Ginseng 225g, Cortex Periplocae 180g, add 8 times of amount 70% alcohol reflux 2 times, 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters decompression filtrate recycling ethanol, be concentrated into relative density and be the clear paste of 1.25-1.30 (60 ℃ of heat are surveyed), standby;
(2), Ramulus Cinnamomi 90g, Pericarpium Citri Reticulatae 75g distillating extracting oil, the aqueous solution of carrying behind the oil filters, standby, residue adds 8 times of amounts of water again and decocted 1 hour, filters, and merges decocting liquid, and is standby;
(3), Radix Aconiti Lateralis Preparata 112.5g, Radix Salviae Miltiorrhizae 225g, Rhizoma Polygonati Odorati 75g, Flos Carthami 90g add 9 times of amount decoctions of water 2 times, each 2 hours.Merge extractive liquid,, filter, merge with Ramulus Cinnamomi, Pericarpium Citri Reticulatae decocting liquid in (2), being concentrated into relative density is 1.25-1.30 (60 ℃ of heat are surveyed) clear paste, add ethanol in the stirring, left standstill below 70%, 4 ℃ 24 hours to determining alcohol, filter, decompression filtrate recycling ethanol, being concentrated into relative density is 1.25-1.30 (60 ℃ of heat are surveyed) clear paste, mixes 65-70 ℃ of oven dry with the alcohol-extracted extract of (1);
(4), dried cream mixed powder becomes 100 order powder, adds 70% ethanol and granulates in right amount, sprays into Ramulus Cinnamomi, Pericarpium Citri Reticulatae volatile oil, mixing, encapsulated, make 1000, promptly.
5, the preparation of drug combination method of treatment chronic heart failure according to claim 4 is characterized in that the dried cream mixture that makes step (1), (2), (3) can be used for preparing clinically the base stock of tablet, electuary, powder.
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