CN102895512A - Application of Chinese medicine composition in preparing medicines for treating rheumatic heart disease - Google Patents

Abstract

The invention discloses an application of a Chinese medicine composition in preparing medicines for treating rheumatic heart disease. The Chinese medicine composition disclosed herein comprises 11 kinds of herbs comprising Astragalus mongholicus, ginseng, salviae miltiorrhizae, etc., and has the effects of tonifying qi and warming yang, activating blood circulation and removing obstruction in channels, and inducing diuresis and removing edema. Experiments prove that the Chinese medicine composition disclosed herein can effectively treat rheumatic heart disease.

Description

The application of a kind of Chinese medicine composition in the medicine of preparation treatment rheumatic heart disease

Technical field

The present invention relates to a kind of new purposes of Chinese medicine composition, particularly, relate to the application of a kind of Chinese medicine composition in the medicine of preparation treatment rheumatic heart disease.

Background technology

Rheumatic fever is a kind of acute or chronic general ICT of common repeatedly outbreak, mainly involves heart, joint, central nervous system, skin and subcutaneous tissue.Usually comparatively obvious with arthritis during acute attack, often leave over the heart damage that weight does not wait after the acute attack, especially remarkable with the valve pathological changes, form chronic rheumatic heart disease.Chronic rheumatic heart disease is one of modal heart disease, invades Bicuspid valve more, cause mitral stenosis or (with) incompetence, next involves aortic valve, cause aortic stenosis or (with) incompetence.The at present treatment of chronic rheumatic heart disease is take surgical operation therapy as main, and the Therapeutic Method of mitral lesion mainly contains enclosed dilatation, percutaneous puncture Balloon Angioplasty, direct-view plasty and prosthetic valve replacement; The treatment of aortic valve be divided into two kinds of plasty and replacements [Chen Haozhu. practical internal medicine (the 12nd edition). Beijing: People's Health Publisher, 2005:2531-2539].These Therapeutic Method often have the drawbacks such as somewhat expensive, wound is large, complication is many, late result is uncertain [Huang Jun, Wang Wen. the large-scale clinical trial of cardiovascular and cerebrovascular disease. Nanjing: Jiangsu science tech publishing house, 1998:802.].

Chinese medicine think rheumatic heart disease belong to more " palpitation with a distress feeling ", " the syndrome of dyspnea ", the category such as " edema ", " obstruction of heart-QI ".Its pathogenesis mainly is to invade in the wind-cold damp pathogen, for a long time and heat-transformation or rheumatism pathogenic heat are directly violated, the interior house in the heart, be to cause blockage of the cardiac vessels, blood vessels are not smooth, blood mistake degree, the heart is become homeless foster, and the mind is uneasy for it, performance cardiopalmus, palpitation with a distress feeling, even yang-energy not cloth on the decline, be difficult warm gasification, and the extremity cold of the limbs, complexion is white all of a sudden, the cheekbone face is dark red, and words are livid purple.Water-damp not being transformed, in attack the lung gold, then overflow outward the skin extremity or under walk between intestinal, see edema, cough is breathed hard, gastral cavity abdomen painful abdominal mass uncomfortable in chest is swollen, can not put down the sleeping card that waits.

The present invention is the improvement invention of carrying out on the basis of Chinese patent ZL 02146573.8, quotes in full the content of this patent document record at this.Chinese patent ZL 02146573.8 does not put down in writing the application of this Chinese medicine composition in the medicine of preparation treatment rheumatic heart disease.

Summary of the invention

The object of the invention provides the application of a kind of Chinese medicine composition in the medicine of preparation treatment rheumatic heart disease.

Medicine of the present invention is the Chinese patent medicine that uses the network ens morbi to develop, formed by the 11 flavor Chinese medicines such as the Radix Astragali, Radix Ginseng, Radix Salviae Miltiorrhizae, with QI invigorating warming YANG medicine for controlling the network heart tonifying, be aided with circulation promoting vein relaxing medicine, make the prosperous blood ruton of gas, rheumatic heart disease can be effectively treated in the resistance of blocking-up blood stasis network.

In the Chinese medicine composition of the present invention, as the latin name of the crude drug of active component and processing method thereof from " Chinese medicine voluminous dictionary " (in July, 1977, front page, Shanghai science tech publishing house) and " Chinese pharmacopoeia (version in 2010, Chinese Medicine science and technology publishing house).

Chinese medicine composition of the present invention is made by the crude drug of following weight portion:

Radix Astragali 150-450 part, Radix Aconiti Lateralis Preparata 40-120 part, Radix Ginseng or Radix Codonopsis 75-225 part, Radix Salviae Miltiorrhizae 75-225 part, Semen Lepidii (Semen Descurainiae) 50-150 part, Cortex Periplocae or CORTEX ACANTHOPANACIS 60-180 part, Rhizoma Alismatis 75-225 part, Rhizoma Polygonati Odorati 25-75 part, Ramulus Cinnamomi 30-90 part, Flos Carthami 30-90 part, Pericarpium Citri Reticulatae 25-75 part;

Preferably, described Chinese medicine composition is made by the crude drug of following weight portion: 450 parts of the Radixs Astragali, 112.5 parts of Radix Aconiti Lateralis Preparatas, Radix Ginseng or 225 parts of Radix Codonopsis, 225 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Lepidii (Semen Descurainiae)s, Cortex Periplocae or 180 parts of CORTEX ACANTHOPANACIS, 225 parts of Rhizoma Alismatis, 75 parts of Rhizoma Polygonati Odorati, 90 parts of Ramulus Cinnamomi, 90 parts on Flos Carthami, 75 parts of Pericarpium Citri Reticulataes;

Or:

250 parts of the Radixs Astragali, 112.5 parts of Radix Aconiti Lateralis Preparatas, Radix Ginseng or 200 parts of Radix Codonopsis, 120 parts of Radix Salviae Miltiorrhizaes, 135 parts of Semen Lepidii (Semen Descurainiae)s, Cortex Periplocae or 150 parts of CORTEX ACANTHOPANACIS, 200 parts of Rhizoma Alismatis, 60 parts of Rhizoma Polygonati Odorati, 75 parts of Ramulus Cinnamomi, 75 parts on Flos Carthami, 60 parts of Pericarpium Citri Reticulataes.

The present invention also provides the active component of described Chinese medicine composition to be made by the following step:

(1) with the Radix Astragali, Semen Lepidii (Semen Descurainiae), Rhizoma Alismatis, Radix Ginseng or Radix Codonopsis, Cortex Periplocae or CORTEX ACANTHOPANACIS 70% ethanol extraction, filter, be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed;

(2) volatile oil of extraction Ramulus Cinnamomi, Pericarpium Citri Reticulatae; The aqueous solution of carrying behind the oil filters, and collects aqueous solution filtrate, decocts with water residue 1 hour again, filters, and merges aqueous solution, must carry water extraction liquid behind the oil;

(3) Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Flos Carthami decoct with water 2 times, and merge extractive liquid, filters; Merge with step (2) gained water extraction liquid, be concentrated into that relative density is the 1.25-1.30 clear paste when 60 ℃ of heat are surveyed, let cool, add ethanol in the stirring, to determining alcohol 70%, leave standstill, filter, filtrate is concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed;

(4) with step (1) gained clear paste with step (3) gained clear paste is mixed, oven dry is pulverized, and adds step (2) gained volatile oil, and get final product.

Chinese medicine composition of the present invention can also be routinely preparation process, for example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record, make the acceptable any conventional dosage form of pharmaceutics, such as capsule, tablet, granule, powder, oral liquid or pill etc.

For above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the acceptable adjuvant of pharmacy, such as the adjuvant of each dosage form record among the model Bi Ting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition), such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.

The present invention also provides the preparation method of this Chinese medicinal composition capsules agent:

(1) takes by weighing in proportion the Radix Astragali, Semen Lepidii (Semen Descurainiae), Rhizoma Alismatis, Radix Ginseng or Radix Codonopsis, Cortex Periplocae or CORTEX ACANTHOPANACIS, add 8 times of amount 70% alcohol reflux 2 times, 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters decompression filtrate recycling ethanol, be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, for subsequent use;

(2) take by weighing in proportion Ramulus Cinnamomi, Pericarpium Citri Reticulatae, extract volatile oil; The aqueous solution of carrying behind the oil filters, and is for subsequent use, and residue adds 8 times of water gagings again and decocted 1 hour, filters, and merges aqueous solution, must carry water extraction liquid behind the oil, for subsequent use;

(3) take by weighing in proportion Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Flos Carthami, add 9 times of amounts of water, decoct 2 times, each 2 hours, merge extractive liquid, filtered, merge with step (2) gained water extraction liquid, be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, let cool, add ethanol in the stirring, left standstill below 70%, 4 ℃ 24 hours to determining alcohol, filter, decompression filtrate recycling ethanol is concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, and is for subsequent use;

(4) with step (1) gained clear paste with step (3) gained clear paste is mixed, 65-70 ℃ of oven dry is ground into 100 order powder, adds 70% appropriate amount of ethanol and granulates, and adds step (2) gained volatile oil, mixing is encapsulated, and get final product.

The consumption of Chinese medicine composition of the present invention, by active component crude drug gross weight, be the 4-20 gram/day, but take every day once, be preferably minute 2-4 time and take; Also be preferably 6-12 gram/day, divide and take for 2-4 time; More preferably 7.59 grams/day, divide and take for 3 times.

Experimental example 1:

For illustrating the curative effect of traditional Chinese medicine composition for treating rheumatic heart disease of the present invention, with having carried out following test by the prepared medicine of embodiment 1 method (hereinafter referred to as medicine of the present invention).

Data and method

1.1 physical data

In January, 2009-2010, year December inventor observed 78 routine Patients With Rheumatic Valvular Diseases altogether in Hebei Yi Ling hospital, all patients all meets in " clinical disease diagnosis according to cure improvement standard " the cardiopathic diagnostic criteria of rheumatic and traditional Chinese medical science deficiency of YANG QI is weary, blood stasis causing water retention is demonstrate,proved dialectical standard, and gets rid of the important organ nonfunction person such as Liver and kidney.78 routine rheumatic heart disease patients are divided into test group and matched group at random, test group 39 examples wherein, male 16 examples, women 23 examples; Average 46.5 years old of age.Clinical manifestation: cardiopalmus, 23 examples of breathing hard, 13 examples of spitting blood, dyspnea, cyanosis 16 examples; Cardiac function II level 18 examples, III level 21 examples.Matched group 39 examples, male 18 examples, women 21 examples; 45.5 years old age.Clinical manifestation: cardiopalmus, 26 examples of breathing hard, 10 examples of spitting blood, dyspnea, cyanosis 18 examples; Cardiac function II level 20 examples, III level 19 examples.The physical data such as 2 groups of Genders, age, the state of an illness by statistics there was no significant difference ( P＞0.05), has comparability.

Therapeutic Method

2 groups of equal routines of patient give benzathine penicillin 1,200,000 units, and intramuscular injection is once carried out prophylactic per month.Test group is taken 4 tablets/times of medicines of the present invention (Shijiazhuang Yiling Pharmaceutical Co., Ltd's production), 3 times/days on this treatment basis.Matched group is taken the precious ball of the heart (heart precious pharmaceutical Co. Ltd in Guangdong produces), 3 tablets/times, 3 times/days on this treatment basis.Be for 8 weeks 2 groups of courses for the treatment of.

Curative effect determinate standard(revise and formulate with reference to " guideline of clinical investigations of new Chinese medicine treatment heart failure " (trying))

Clinical recent healing: cardiac function is corrected to the I level, and symptom, sign disappear substantially, and it is normal that every inspection recovers substantially;

Produce effects: the cardiac function progress is more than 2 grades, and do not reach I level cardiac function, and symptom, sign and every inspection obviously improve;

Effectively: 1 grade of cardiac function progress, and do not reach I level cardiac function, symptom, sign and every inspection make moderate progress;

Invalid: cardiac function is without significant change, or increases the weight of.

The result

Clinical recent healing 6 examples of test group, produce effects 12 examples, effective 14 examples, total effective rate is 82.05%; Clinical recent healing 4 examples of matched group, produce effects 10 examples, effective 12 examples, total effective rate is 66.67%.2 groups of total effective rates relatively have significant difference ( P＜0.05), test group is higher than matched group.

Conclusion

Can be confirmed that by above experiment Chinese medicine composition of the present invention can effectively be treated rheumatic heart disease, determined curative effect is not found obvious adverse reaction.

The specific embodiment

Embodiment 1: the preparation of medicine capsule of the present invention

Prescription:

Radix Astragali 450g Radix Aconiti Lateralis Preparata 112.5g Radix Ginseng 225g Radix Salviae Miltiorrhizae 225g Semen Lepidii (Semen Descurainiae) 150g Cortex Periplocae 180g Rhizoma Alismatis 225g Flos Carthami 90g Rhizoma Polygonati Odorati 75g Pericarpium Citri Reticulatae 75g Ramulus Cinnamomi 90g

Preparation method:

(1) takes by weighing the Radix Astragali, Semen Lepidii (Semen Descurainiae), Rhizoma Alismatis, Radix Ginseng, Cortex Periplocae according to the prescription ratio, add 8 times of amount 70% alcohol reflux 2 times, 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters decompression filtrate recycling ethanol, be concentrated into 60 ℃ of mensuration relative densities and be the clear paste of 1.25-1.30, for subsequent use;

(2) take by weighing Ramulus Cinnamomi, Pericarpium Citri Reticulatae, distillating extracting oil according to the prescription ratio; The aqueous solution of carrying behind the oil filters, and is for subsequent use, and residue adds 8 times of water gagings again and decocted 1 hour, filters, and merges decocting liquid, and is for subsequent use;

(3) take by weighing Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Flos Carthami according to the prescription ratio, add 9 times of amounts of water, decoct 2 times, each 2 hours, merge extractive liquid, filters, and merges with Ramulus Cinnamomi, Pericarpium Citri Reticulatae aqueous solution in the step (2), being concentrated into 60 ℃ of mensuration relative densities is the 1.25-1.30 clear paste, let cool, add ethanol in the stirring, to determining alcohol 70%, left standstill below 4 ℃ 24 hours, filter, decompression filtrate recycling ethanol, being concentrated into 60 ℃ of mensuration relative densities is the 1.25-1.30 clear paste, mix 70 ℃ of oven dry with the alcohol extraction clear paste of step (1);

(4) dried cream mixed powder is broken into 100 order powder, adds 70% appropriate amount of ethanol and granulates, and sprays into Ramulus Cinnamomi, Pericarpium Citri Reticulatae volatile oil, and mixing is encapsulated, makes 1000, and get final product.

Usage and dosage: each 4, every day 3 times.

Embodiment 2: the preparation of active component

Prescription:

Radix Astragali 450g Radix Aconiti Lateralis Preparata 112.5g Radix Ginseng 225g Radix Salviae Miltiorrhizae 225g Semen Lepidii (Semen Descurainiae) 150g Cortex Periplocae 180g Rhizoma Alismatis 225g Flos Carthami 90g Rhizoma Polygonati Odorati 75g Pericarpium Citri Reticulatae 75g Ramulus Cinnamomi 90g

Preparation method:

(1) proportionally takes by weighing the Radix Astragali, Semen Lepidii (Semen Descurainiae), Rhizoma Alismatis, Radix Ginseng, Cortex Periplocae, use 70% ethanol extraction, filter, be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed;

(2) proportionally take by weighing Ramulus Cinnamomi, Pericarpium Citri Reticulatae, extract volatile oil; The aqueous solution of carrying behind the oil filters, and collects aqueous solution filtrate, decocts with water residue 1 hour again, filters, and merges decocting liquid, must carry water extraction liquid behind the oil;

(3) proportionally take by weighing Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Flos Carthami, decoct with water 2 times, merge extractive liquid, filters; Merge with step (2) gained water extraction liquid, being concentrated into relative density is the 1.25-1.30 clear paste, lets cool, and adds ethanol in the stirring, to determining alcohol 70%, leaves standstill, and filters, and filtrate is concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed;

(4) with step (1) gained clear paste with step (3) gained clear paste is mixed, oven dry is pulverized, and adds step (2) gained volatile oil, and get final product.

Embodiment 3: the preparation of medicinal tablet of the present invention

Prescription:

Radix Astragali 150g Radix Aconiti Lateralis Preparata 40g Radix Ginseng 225g Radix Salviae Miltiorrhizae 225g Semen Lepidii (Semen Descurainiae) 50g Cortex Periplocae 180g Rhizoma Alismatis 75g Rhizoma Polygonati Odorati 75g Ramulus Cinnamomi 30g Flos Carthami 90g Pericarpium Citri Reticulatae 25g

Preparation method:

(1) takes by weighing the Radix Astragali, Semen Lepidii (Semen Descurainiae), Rhizoma Alismatis, Radix Ginseng, Cortex Periplocae according to the prescription ratio, add 8 times of amount 70% alcohol reflux 2 times, 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters decompression filtrate recycling ethanol, be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, for subsequent use;

(2) take by weighing Ramulus Cinnamomi, Pericarpium Citri Reticulatae according to the prescription ratio, distillating extracting oil, the aqueous solution of carrying behind the oil filters, and is for subsequent use, and residue adds 8 times of water gagings again and decocted 1 hour, filters, and merges decocting liquid, and is for subsequent use;

(3) take by weighing Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Flos Carthami according to the prescription ratio, adding 9 times of amounts of water decocts 2 times, each 2 hours, merge extractive liquid,, filter, merge with Ramulus Cinnamomi, Pericarpium Citri Reticulatae decocting liquid in the step (2), be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, let cool, add ethanol in the stirring, left standstill below 70%, 4 ℃ 24 hours to determining alcohol, filter, decompression filtrate recycling ethanol, be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, mix 65 ℃ of oven dry with the alcohol extraction clear paste of step (1);

(4) dried cream mixed powder is broken into 100 order powder, adds 70% appropriate amount of ethanol and granulates, and sprays into Ramulus Cinnamomi, Pericarpium Citri Reticulatae volatile oil, mixing, and formulation method is made tablet routinely.

Embodiment 4: the preparation of medicinal granule of the present invention

Prescription:

Radix Astragali 250g Radix Aconiti Lateralis Preparata 112.5g Radix Codonopsis 200g Radix Salviae Miltiorrhizae 120g Semen Lepidii (Semen Descurainiae) 135g

CORTEX ACANTHOPANACIS 150g Rhizoma Alismatis 200g Rhizoma Polygonati Odorati 60g Ramulus Cinnamomi 75g Flos Carthami 75g Pericarpium Citri Reticulatae 60g

Preparation method:

(1) takes by weighing the Radix Astragali, Semen Lepidii (Semen Descurainiae), Rhizoma Alismatis, Radix Ginseng, Cortex Periplocae according to the prescription ratio, add 8 times of amount 70% alcohol reflux 2 times, 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters decompression filtrate recycling ethanol, be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, for subsequent use;

(2) take by weighing Ramulus Cinnamomi, Pericarpium Citri Reticulatae according to the prescription ratio, distillating extracting oil, the aqueous solution of carrying behind the oil filters, and is for subsequent use, and residue adds 8 times of water gagings again and decocted 1 hour, filters, and merges decocting liquid, and is for subsequent use;

(3) take by weighing Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Flos Carthami according to the prescription ratio, adding 9 times of amounts of water decocts 2 times, each 2 hours, merge extractive liquid,, filter, merge with Ramulus Cinnamomi, Pericarpium Citri Reticulatae decocting liquid in the step (2), be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, let cool, add ethanol in the stirring, left standstill below 70%, 4 ℃ 24 hours to determining alcohol, filter, decompression filtrate recycling ethanol, be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, mix 70 ℃ of oven dry with the alcohol extraction clear paste of step (1);

(4) dried cream mixed powder is broken into 100 order powder, adds 70% appropriate amount of ethanol and granulates, and sprays into Ramulus Cinnamomi, Pericarpium Citri Reticulatae volatile oil, mixing, the routinely agent of formulation method granulation.

Claims (8)

1. the Chinese medicine composition application in the medicine of preparation treatment rheumatic heart disease is characterized in that described Chinese medicine composition made by the crude drug of following weight portion:

Radix Astragali 150-450 part, Radix Aconiti Lateralis Preparata 40-120 part, Radix Ginseng or Radix Codonopsis 75-225 part, Radix Salviae Miltiorrhizae 75-225 part, Semen Lepidii (Semen Descurainiae) 50-150 part, Cortex Periplocae or CORTEX ACANTHOPANACIS 60-180 part, Rhizoma Alismatis 75-225 part, Rhizoma Polygonati Odorati 25-75 part, Ramulus Cinnamomi 30-90 part, Flos Carthami 30-90 part, Pericarpium Citri Reticulatae 25-75 part.

2. application as claimed in claim 1 is characterized in that described Chinese medicine composition made by the crude drug of following weight portion:

450 parts of the Radixs Astragali, 112.5 parts of Radix Aconiti Lateralis Preparatas, Radix Ginseng or 225 parts of Radix Codonopsis, 225 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Lepidii (Semen Descurainiae)s, Cortex Periplocae or 180 parts of CORTEX ACANTHOPANACIS, 225 parts of Rhizoma Alismatis, 75 parts of Rhizoma Polygonati Odorati, 90 parts of Ramulus Cinnamomi, 90 parts on Flos Carthami, 75 parts of Pericarpium Citri Reticulataes.

3. application as claimed in claim 1 is characterized in that described Chinese medicine composition made by the crude drug of following weight portion:

150 parts of the Radixs Astragali, 40 parts of Radix Aconiti Lateralis Preparatas, Radix Ginseng or 225 parts of Radix Codonopsis, 225 parts of Radix Salviae Miltiorrhizaes, 50 parts of Semen Lepidii (Semen Descurainiae)s, Cortex Periplocae or 180 parts of CORTEX ACANTHOPANACIS, 75 parts of Rhizoma Alismatis, 75 parts of Rhizoma Polygonati Odorati, 30 parts of Ramulus Cinnamomi, 90 parts on Flos Carthami, 25 parts of Pericarpium Citri Reticulataes.

4. application as claimed in claim 1 is characterized in that described Chinese medicine composition made by the crude drug of following weight portion:

250 parts of the Radixs Astragali, 112.5 parts of Radix Aconiti Lateralis Preparatas, Radix Ginseng or 200 parts of Radix Codonopsis, 120 parts of Radix Salviae Miltiorrhizaes, 135 parts of Semen Lepidii (Semen Descurainiae)s, Cortex Periplocae or 150 parts of CORTEX ACANTHOPANACIS, 200 parts of Rhizoma Alismatis, 60 parts of Rhizoma Polygonati Odorati, 75 parts of Ramulus Cinnamomi, 75 parts on Flos Carthami, 60 parts of Pericarpium Citri Reticulataes.

5. such as the arbitrary described application of claim 1-4, the active component of wherein said Chinese medicine composition is made by following steps:

(1) with the Radix Astragali, Semen Lepidii (Semen Descurainiae), Rhizoma Alismatis, Radix Ginseng or Radix Codonopsis, Cortex Periplocae or CORTEX ACANTHOPANACIS 70% ethanol extraction, filter, be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed;

(2) volatile oil of extraction Ramulus Cinnamomi, Pericarpium Citri Reticulatae; The aqueous solution of carrying behind the oil filters, and collects aqueous solution filtrate, decocts with water residue 1 hour again, filters, and merges aqueous solution, must carry water extraction liquid behind the oil;

(3) Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Flos Carthami decoct with water 2 times, and merge extractive liquid, filters; Merge with step (2) gained water extraction liquid, be concentrated into that relative density is the 1.25-1.30 clear paste when 60 ℃ of heat are surveyed, let cool, add ethanol in the stirring, to determining alcohol 70%, leave standstill, filter, filtrate is concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed;

(4) with step (1) gained clear paste with step (3) gained clear paste is mixed, oven dry is pulverized, and adds step (2) gained volatile oil, and get final product.

6. application as claimed in claim 5, the pharmaceutical preparation that it is characterized in that described active component is capsule, tablet, granule, powder, oral liquid or pill.

7. such as each described application among the claim 1-4, the pharmaceutical preparation that it is characterized in that described Chinese medicine composition is capsule, tablet, granule, powder, oral liquid or pill.

8. application as claimed in claim 6 is characterized in that described Chinese medicinal composition capsules agent is to be made by following steps:

(1) takes by weighing in proportion the Radix Astragali, Semen Lepidii (Semen Descurainiae), Rhizoma Alismatis, Radix Ginseng or Radix Codonopsis, Cortex Periplocae or CORTEX ACANTHOPANACIS, add 8 times of amount 70% alcohol reflux 2 times, 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters decompression filtrate recycling ethanol, be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, for subsequent use;

(2) take by weighing in proportion Ramulus Cinnamomi, Pericarpium Citri Reticulatae, extract volatile oil; The aqueous solution of carrying behind the oil filters, and is for subsequent use, and residue adds 8 times of water gagings again and decocted 1 hour, filters, and merges aqueous solution, must carry water extraction liquid behind the oil, for subsequent use;

(3) take by weighing in proportion Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Flos Carthami, add 9 times of amounts of water, decoct 2 times, each 2 hours, merge extractive liquid, filtered, merge with step (2) gained water extraction liquid, be concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, let cool, add ethanol in the stirring, left standstill below 70%, 4 ℃ 24 hours to determining alcohol, filter, decompression filtrate recycling ethanol is concentrated into that relative density is the clear paste of 1.25-1.30 when 60 ℃ of heat are surveyed, and is for subsequent use;

(4) with step (1) gained clear paste with step (3) gained clear paste is mixed, 65-70 ℃ of oven dry is ground into 100 order powder, adds 70% appropriate amount of ethanol and granulates, and adds step (2) gained volatile oil, mixing is encapsulated, and get final product.