CN104857459A - Heart failure treating traditional Chinese medicine composition and preparation method thereof - Google Patents

Abstract

The present invention discloses a heart failure treating traditional Chinese medicine composition and preparation method thereof, which comprises, by weight, 20-30 g of cinnamomum cassia, 20-30 g of dried ginger, 20-30 g of milkvetch root, 15-25 g of trichosanthes kirilowii maxi, 15-25 g of scutellaria baicalensis, 15-25 g of pericarpium citri reticulatae, 15-25 g of radix linderae, 15-25 g of caulis spatholobi, 15-25 g of herba lycopi, 15-25 g of codonopsis pilosula, 10-20 g of eucommia ulmoides, 15-25 g of apricot kernel, 10-20 g of cacumen platycladi, 10-20 g of magnolia officinalis, 10-20 g of dendrobium, 10-20 g of cortex lycii, and 8-15 g of licorice root. The heart failure treating traditional Chinese medicine composition of the present invention has effects of qi benefiting, heart enhancing, spleen strengthening, diuresis inducing, blood circulation activating, blood stasis dissipating, and symptom and root cause treatment, and further has characteristics of exact treatment effect and significant effect.

Description

A kind of Chinese medicine composition for the treatment of heart failure and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, particularly a kind of Chinese medicine composition for the treatment of heart failure and preparation method thereof.

Background technology

Heart failure belongs to the category such as Chinese medicine " the syndrome of dyspnea ", " thoracic obstruction ", " cardiopalmus ", and " Plain Questions numbness opinion " is said: " obstruction of heart-QI person, arteries and veins is obstructed, tired then severe palpitation, sudden and violent upper gas and breathing heavily." it pants, has palpitation, weak, breathe hard, and dynamic then more so, belong to deficiency of vital energy performance; Uncomfortable in chest, chest pain, purplish tongue are levying of blood-stasis internal-depression; And this kind of patient's course of disease is long, " prolonged illness must be empty ", " pathogen usually intruding into collateral in protracted disease ", therefore its main pathogenesis is deficiency of vital energy yang deficiency folder blood stasis, deficiency of vital energy yang deficiency is this, and blood stasis is mark; Sick position, at the heart, relates to lung, kidney.The method that the traditional Chinese medical science treats heart failure at present mainly contains " warming YANG, invigorate blood circulation, diuretic ", and the method for " heart tonifying, diuresis, expansion blood vessel " that this and doctor trained in Western medicine are traditional is reach the same goal by different routes.Closely, blood vessel dilating, heart tonifying, diuresis are the basic skills of western medical treatment heart failure to its therapeutic and toxic dose of digitalis cardiac tonic of western medical treatment heart failure application.Generally speaking, the rule for the treatment of such as main employing " blood circulation promoting and blood stasis dispelling, QI invigorating warming YANG, diuretic damp eliminating ", often select the prescription plus-minus treatments such as SHENGMAI SAN, Zhen Wu Tang, Decoction for strengthening the Spleen-Yang, Brassicaceae Chinese jujube Lung Soup.Key agents comprises the Cardiac glycosides such as Herba Adonidis, Herba Convallariae, periploca sepium, Rohdea japonica Roth, Semen Lepidii (Semen Descurainiae), Venenum Bufonis, and the non-Cardiac glycosides two kinds such as Radix Ginseng, Radix Aconiti Lateralis Preparata, the Radix Astragali, Radix Ophiopogonis, Fructus Aurantii Immaturus, Rhizoma Zingiberis Recens, Cortex Cinnamomi.But the clinical efficacy of TCM Recipe medicine does not obtain significant breakthrough, owing to being confined to the understanding of traditional etiology and pathogenesis, so Therapeutic Method except warming YANG, invigorate blood circulation, except diuretic, also have the methods such as eliminating the pathogens from the lung, yin nourishing, QI invigorating, although result of study also proves to be improved myocardial contraction, improve the effects such as symptom, but do not bring breakthrough.

Heart failure is satisfactory functional defect also.Heart weakens because of disease, overwork, ejection function, can not meet organ and anabolic needs down to blood discharge amount.Cardinal symptom is dyspnea, pant, edema etc.Due to myocardial contraction weaken cardiac output decline to such an extent as to tissue and organ perfusion quantity not sufficient occur simultaneously pulmonary circulation or with the performance of body circulation blood stasis.If left heart failure has pulmonary venous pleonaemia, can dyspnea! If right heart failure has gastrointestinal congestion, so anorexia, feel sick, abdominal distention! Cardiac pumping function is poor, and it is bad so lower limb that peripheral blood returns the heart, blepharoedema, due to patient's pulmonary venous pleonaemia, so aggravation to be that patient can not put down sleeping! But a lot of patient is whole heart failure clinically, and this situation increases treatment difficulty more.This heart failure course of disease is longer, protracted course of disease, normal deficiency of YANG affecting YIN, and deficiency of YIN affecting YANG, causes deficiency of both YIN and YANG, and the state of an illness is complicated, the performances such as the visible deficiency of vital energy of pathogeny, yang deficiency, the deficiency of YIN, blood stasis, poison heresy.

Current western medical treatment heart failure still owes desirable to some cases.Diuretic can make electrolyte imbalance; Digitalis preparation individual variation is very large, and toxic dose and therapeutic dose are close to even overlapping sometimes, or because of poor to Folium Digitalis Purpureae toleration, easily cause poisoning or cause arrhythmia; Part vasodilation has certain side effect or unsuitable prolonged application.So we attempt to treat with Chinese medicine, the traditional Chinese medical science thinks that the pathogenesis crux point of heart failure is motive yang deficiency, stagnation of heart-blood., mainly at the heart, there is substantial connection the sick position of gas yang deficiency with the internal organs such as lung, spleen, kidney.Primary disease character many genus deficiency in origin and excess in superficiality.Deficiency of heart-YANG is this, and blood stasis, expectorant are turbid is mark.Controlling QI invigorating warming YANG, blood circulation promoting and blood stasis dispelling to be method, applies in a flexible way, primary disease can be made to be treated preferably according to clinical practice situation.Heart failure is the card of deficiency in origin and excess in superficiality, is motive virtual loss, is being designated as blood-vessel obstructive, fluid-retention stagnating in the interior at this." edema with the heart involved " disease of the similar traditional Chinese medical science, when mark is principal contradiction in fact, Chinese medical book advocates to attach most importance to expelling fluid-retention mostly.As " Standards of Diagnosis and Treatment " day: " if deficiency of heart-QI, kidney water insults it, and the inverse upper and person that stops the heart, must roll over inverse gas, rush down its water, mend its sun.The quality of cardiac function is decided by the prosperity and decline of healthy energy, and in healthy energy is deposited, heresy can not be done.And morbidity is artificial the highest with old age, the disease in old age mostly is empty, so pathogenesis is deficiency in origin and excess in superficiality.Void comprises the void of the five internal organs, but to have a guilty conscience as principal contradiction, has a guilty conscience and must involve yang blood and qi, is then gently deficiency of vital energy blood deficiency, heavy then yang blood and qi is all empty, very then faints de-.Actually be " expectorant " and " stasis of blood ".As for who problem first after whom of Virtual and actual, general theory thinks first have void, and rear just have reality.Having a guilty conscience, it is smooth to cause QI and blood to lose, gas and blood, interdependence between yin and yang, qi as the commander of blood, and blood being the mother of qi, and blood is capable with gas, and up to row then blood, gas is that initiatively blood is passive.The deficiency of vital energy is raw expectorant then, and stop then disorder of QI movement in phlegm-damp, the stagnation of QI hyperamization stasis of blood, deficiency of vital energy blood is weak, the hyperamization stasis of blood again, and blood stasis can react on gas, causes the stagnation of QI or the deficiency of vital energy increases the weight of further.Blockage of the cardiac vessels, the blood stasis of blood is stagnant is its Etiological.

Therefore, need to occur that a kind of proportioning is simple, easy to use, the removing toxic substances of tonifying Yin and Yang, QI invigorating, blood circulation promoting and blood stasis dispelling, QI invigorating warming YANG, diuretic damp eliminating, improve a kind of Chinese medicine composition for the treatment of heart failure of cardiac pumping ability and preparation method thereof.

Summary of the invention

Technical problem to be solved by this invention is, there is provided a kind of proportioning simple, easy to use, the removing toxic substances of tonifying Yin and Yang, QI invigorating, blood circulation promoting and blood stasis dispelling, QI invigorating warming YANG, diuretic damp eliminating, improve a kind of Chinese medicine composition for the treatment of heart failure of cardiac pumping ability and preparation method thereof.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of heart failure, wherein, comprising the following component according to unit of weight configuration: Cortex Cinnamomi 20-30g, Rhizoma Zingiberis 20-30g, Radix Astragali 20-30g, Fructus Trichosanthis 15-25g, Radix Scutellariae 15-25g, Pericarpium Citri Reticulatae 15-25g, Radix Linderae 15-25g, Caulis Spatholobi 15-25g, Herba Lycopi 15-25g, Radix Codonopsis 15-25g, Cortex Eucommiae 10-20g, Semen Armeniacae Amarum 15-25g, Cacumen Platycladi 10-20g, Cortex Magnoliae Officinalis 10-20g, Herba Dendrobii 10-20g, Cortex Lycii 10-20g, Radix Glycyrrhizae 8-15g.

Or, comprise the following component according to unit of weight configuration: Cortex Cinnamomi 20-25g, Rhizoma Zingiberis 20-25g, Radix Astragali 20-25g, Fructus Trichosanthis 15-20g, Radix Scutellariae 15-20g, Pericarpium Citri Reticulatae 15-20g, Radix Linderae 15-20g, Caulis Spatholobi 15-20g, Herba Lycopi 15-20g, Radix Codonopsis 15-20g, Cortex Eucommiae 10-15g, Semen Armeniacae Amarum 15-20g, Cacumen Platycladi 10-15g, Cortex Magnoliae Officinalis 10-15g, Herba Dendrobii 10-15g, Cortex Lycii 10-15g, Radix Glycyrrhizae 8-12g.

Or, comprise the following component according to unit of weight configuration: Cortex Cinnamomi 25-30g, Rhizoma Zingiberis 25-30g, Radix Astragali 25-30g, Fructus Trichosanthis 20-25g, Radix Scutellariae 20-25g, Pericarpium Citri Reticulatae 20-25g, Radix Linderae 20-25g, Caulis Spatholobi 20-25g, Herba Lycopi 20-25g, Radix Codonopsis 20-25g, Cortex Eucommiae 15-20g, Semen Armeniacae Amarum 20-25g, Cacumen Platycladi 15-20g, Cortex Magnoliae Officinalis 15-20g, Herba Dendrobii 15-20g, Cortex Lycii 15-20g, Radix Glycyrrhizae 10-15g.

Or, comprise the following component according to unit of weight configuration: Cortex Cinnamomi 22-28g, Rhizoma Zingiberis 22-28g, Radix Astragali 22-28g, Fructus Trichosanthis 18-22g, Radix Scutellariae 18-22g, Pericarpium Citri Reticulatae 18-22g, Radix Linderae 18-22g, Caulis Spatholobi 18-22g, Herba Lycopi 18-22g, Radix Codonopsis 18-22g, Cortex Eucommiae 12-18g, Semen Armeniacae Amarum 18-22g, Cacumen Platycladi 12-18g, Cortex Magnoliae Officinalis 12-18g, Herba Dendrobii 12-18g, Cortex Lycii 12-18g, Radix Glycyrrhizae 9-13g.

The present invention can be decocted in water for oral dose, potion on the one, within 1st, takes at twice, within 10 days, is a course for the treatment of.

The preparation method of the Chinese medicine composition for the treatment of heart failure, is characterized in that,

Dosage form is capsule, its preparation method comprises the following steps: described component is added weight 10 times amount ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 DEG C 1.08; Described filtrate flow is the macroporous adsorptive resins of 10L through volume, uses deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule.

Advantage of the present invention: to invigorate vital energy and reinforce the heart, invigorating spleen for diuresis, blood circulation promoting and blood stasis dispelling, has the function for the treatment of both the principal and secondary aspects of a disease, determined curative effect, Be very effective.Compared with prior art teach, the present invention has clear superiority: after use, has positive inotropic action to heart, strengthens myocardial contraction, and increase coronary artery blood flow, protecting myocardial cell, improves cardiac function.Obviously can improve the hemodynamics disturbance of patients with heart failure, improve cardiac function and left ventricular remodeling; Its mechanism may with to improve myocardial cell energy metabolism relevant.The present invention effectively can treat heart failure, corrects hemodynamics disturbance, and the cardiac function of the person that improves heart failure improves short term effect; Exhaustion cardiac muscle remodeling ventricle can be reversed, thus the long-term prognosis of the person that improves heart failure; Also prompting can prolonged application and non-evident effect.

Detailed description of the invention

The Chinese medicine composition for the treatment of heart failure, wherein, comprises the following component according to unit of weight configuration: Cortex Cinnamomi 20-30g, Rhizoma Zingiberis 20-30g, Radix Astragali 20-30g, Fructus Trichosanthis 15-25g, Radix Scutellariae 15-25g, Pericarpium Citri Reticulatae 15-25g, Radix Linderae 15-25g, Caulis Spatholobi 15-25g, Herba Lycopi 15-25g, Radix Codonopsis 15-25g, Cortex Eucommiae 10-20g, Semen Armeniacae Amarum 15-25g, Cacumen Platycladi 10-20g, Cortex Magnoliae Officinalis 10-20g, Herba Dendrobii 10-20g, Cortex Lycii 10-20g, Radix Glycyrrhizae 8-15g.

Or, comprise the following component according to unit of weight configuration: Cortex Cinnamomi 20-25g, Rhizoma Zingiberis 20-25g, Radix Astragali 20-25g, Fructus Trichosanthis 15-20g, Radix Scutellariae 15-20g, Pericarpium Citri Reticulatae 15-20g, Radix Linderae 15-20g, Caulis Spatholobi 15-20g, Herba Lycopi 15-20g, Radix Codonopsis 15-20g, Cortex Eucommiae 10-15g, Semen Armeniacae Amarum 15-20g, Cacumen Platycladi 10-15g, Cortex Magnoliae Officinalis 10-15g, Herba Dendrobii 10-15g, Cortex Lycii 10-15g, Radix Glycyrrhizae 8-12g.

Or, comprise the following component according to unit of weight configuration: Cortex Cinnamomi 25-30g, Rhizoma Zingiberis 25-30g, Radix Astragali 25-30g, Fructus Trichosanthis 20-25g, Radix Scutellariae 20-25g, Pericarpium Citri Reticulatae 20-25g, Radix Linderae 20-25g, Caulis Spatholobi 20-25g, Herba Lycopi 20-25g, Radix Codonopsis 20-25g, Cortex Eucommiae 15-20g, Semen Armeniacae Amarum 20-25g, Cacumen Platycladi 15-20g, Cortex Magnoliae Officinalis 15-20g, Herba Dendrobii 15-20g, Cortex Lycii 15-20g, Radix Glycyrrhizae 10-15g.

Or, comprise the following component according to unit of weight configuration: Cortex Cinnamomi 22-28g, Rhizoma Zingiberis 22-28g, Radix Astragali 22-28g, Fructus Trichosanthis 18-22g, Radix Scutellariae 18-22g, Pericarpium Citri Reticulatae 18-22g, Radix Linderae 18-22g, Caulis Spatholobi 18-22g, Herba Lycopi 18-22g, Radix Codonopsis 18-22g, Cortex Eucommiae 12-18g, Semen Armeniacae Amarum 18-22g, Cacumen Platycladi 12-18g, Cortex Magnoliae Officinalis 12-18g, Herba Dendrobii 12-18g, Cortex Lycii 12-18g, Radix Glycyrrhizae 9-13g.

Compound Chinese medicinal preparation pharmacodynamic study of the present invention:

1, after insufficiency of heart-QI model mice application compound Chinese medicinal preparation of the present invention, obvious inhibitory action is had to hanging the anxiety caused; The length of one's sleep is extended; Muscular tension increases, stand up time extends; Adopt water maze to record memory to increase; Under normal pressure, hypoxia endurance time extends; Insufficiency of heart-QI mice heart rate is recovered;

2, after normal mouse application compound Chinese medicinal preparation of the present invention, obvious sedation is had to the anxiety that forced swimming method and suspension method cause; The length of one's sleep of mice is obviously extended; Significantly improve immunologic function, mononuclear phagocyte phagocytic index and activate the phagocytic capacity are obviously increased, and mice serum amboceptor significantly raises;

3, obvious reducing effect is had to the hypertension of neuroendocrine type Hypertensive Rats; Heart rate obviously recovers; The length of one's sleep, significant prolongation, had obvious synergism with pentobarbital sodium; Visible with water maze test, the memory of rat model is increased, and the time stopped in labyrinth obviously shortens; Visible with head-breaking test, the time of opening one's mouth after Chinese medicine composition of the present invention makes rat break end obviously extends.

Acute toxicity testing:

The Mouse oral maximum dosage-feeding of Chinese medicine composition of the present invention is 210g crude drug/kg, calculates, be equivalent to 1215 times of Coming-of-Age Day consumption 8.8g by kg body weight, calculates, be equivalent to 167 times by body surface area; It is 41.375 crude drugs/kg that intraperitoneal administration records its LD50, and it 95% is crediblely limited to 35.243 ~ 42.068g crude drug/kg.Illustrate that compound Chinese medicinal preparation oral toxicity of the present invention is low, clinical practice is safer.

Long term toxicity test:

Compound Chinese medicinal preparation of the present invention presses 7.69,19.18 and 43.21g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of compound Chinese medicinal preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that compound Chinese medicinal preparation of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Pharmacological effect

One, the present invention is on the impact of experimental heart failure domesticated dog arteria coronaria renal blood flow

1 materials and methods:

1.1 experiment materials:

1.1.1 animal: healthy adult experimental dog 20, body weight 13.27 ± 0.59kg, male and female dual-purpose.

1.1.2 medicine: drop pill of the present invention; Pentobarbital sodium; Digoxin 0.25mg/ sheet; Heparin sodium injection; 0.9% sodium chloride injection.Above-mentioned Experimental agents becomes equal-volume 3ml/kg, through duodenal administration with normal saline all on pretreatment except pentobarbital sodium, heparin.

1.2 experiment groupings: laboratory animal is divided into four groups at random, often organizes 5.A group: be blank group, raises with normal saline 3ml/kg in experiment; B group: low dose group of the present invention, 5g crude drug/kg; C group: high dose group of the present invention, 10g crude drug/kg; D group: positive controls, digoxin 100 μ g/kg.

1.3 experimental techniques: laboratory animal pentobarbital sodium 30mg/kg intravenous anesthesia, tracheal intubation, connects phrenoton and is separated right lateral thigh vein & connection constant speed peristaltic pump, in order to input pentobarbital sodium; Be separated right common femoral artery, intubate, measure arteriotony BP; Left side the 4th intercostal opens breast, exposes heart, cuts off pericardium, make pericardium bed, is separated LCA and aorta, places electromagnetic flowmeter probe respectively, measures coronary flow CBF and cardiac output CO.Abdominal operation is separated renal artery and places electromagnetic flowmeter probe, measures renal artery blood flow amount KBF.Above-mentioned indices synchronous recording is in polygraph.Implement abdominal operation, duodenal intubation, in order to giving tested medicine.Intravenous injection heparin injection 125U/kg carries out heparinization, and after 30 minutes, record indices, as basic value before drop pill of the present invention.Input 2% pentobarbital sodium through peristaltic pump constant speed, input quantity is 0.2ml/minkg.Decline 70% as heart failure index using left ventricular pressure change maximum rate, adjusting the pentobarbital sodium amount of feeding after reaching this value is 0.08ml/minkg, continues 15 minutes, makes left ventricular end diastolic presssure keep stable, records index after every heart failure, value before medicine.Duodenum feeds tested medicine.Every observation index is recorded respectively at after medicine 10,20,30,40,60,90,120,180 minutes.

1.4 statistical methods adopt t inspection and X ²inspection.

Result: drop pill of the present invention two dosage groups have the effect of increase CBF in various degree, after medicine 90 minutes, 10g crude drug/kg dosage group CBF increases to 39.61 ± 16.51ml/min from 20.78 ± 8.06ml/min before medicine, increase by 81.16% ± 17.24%, compare P < 0.05 with before medicine and compare P < 0.01 with matched group that all there were significant differences.Drop pill of the present invention two dosage groups are not remarkable on CO impact.Two dosage groups all obviously can increase KBF, compare with before medicine and with matched group more all there were significant differences P < 0.05 ~ 0.01.

This research confirms, drop pill of the present invention can improve coronary artery and arteriorenal blood flow effectively, the treatment of the heart failure that the heart disease that not only can contribute to a variety of causes causes, and the coronary artery caused heart failure, the reduction of renal artery blood flow amount and the damage of renal function have obvious curative effect.

Example 1: grandson, man, 59 years old, has history of coronary heart disease, cardiopalmus, angina pectoris, arrhythmia, and electrocardiogram shows: deficiency myocardial blood supply, ventricular premature contraction.Often there is heart failure, time have dyspnea, can not put down sleeping, two lower lower limb has pitting edema, blue-purplish tongue, deep-thready pulse knot generation.Clinical diagnosis: angina pectoris, arrhythmia, heart failure III °.Following formula is used to treat:

Cortex Cinnamomi 30g, Rhizoma Zingiberis 30g, Radix Astragali 30g, Fructus Trichosanthis 25g, Radix Scutellariae 25g, Pericarpium Citri Reticulatae 25g, Radix Linderae 25g, Caulis Spatholobi 25g, Herba Lycopi 25g, Radix Codonopsis 25g, Cortex Eucommiae 20g, Semen Armeniacae Amarum 25g, Cacumen Platycladi 20g, Cortex Magnoliae Officinalis 20g, Herba Dendrobii 20g, Cortex Lycii 20g, Radix Glycyrrhizae 15g.

Take decoction of the present invention, take 2 day, take medicine 10, symptom alleviates, and takes medicine 30, and arrhythmia reduces, and continues medication and consolidates for 6 months, cure, follow up a case by regular visits to 6 years, do not recur after clinical 1 year.

Example 2: Zhang, female, 56 years old, history of coronary heart disease 2 years, cardiopalmus angina pectoris, atrial fibrillation, electrocardiogram: deficiency myocardial blood supply, atrial fibrillation.Clinical main suit: have dyspnea when sitting quietly, sleeping, fatigue and weak can not be put down, white expectorant of coughing, two lower limb severe edema, blue-purplish tongue, deep-thready pulse knot generation.Clinical diagnosis: angina pectoris, atrial fibrillation, intrapulmonary infection, heart failure III °.Take decoction of the present invention, use following formula:

Cortex Cinnamomi 20g, Rhizoma Zingiberis 20g, Radix Astragali 20g, Fructus Trichosanthis 15g, Radix Scutellariae 15g, Pericarpium Citri Reticulatae 15g, Radix Linderae 15g, Caulis Spatholobi 15g, Herba Lycopi 15g, Radix Codonopsis 15g, Cortex Eucommiae 10g, Semen Armeniacae Amarum 15g, Cacumen Platycladi 10g, Cortex Magnoliae Officinalis 10g, Herba Dendrobii 10g, Cortex Lycii 10g, Radix Glycyrrhizae 8g.

Take decoction of the present invention, take 2 day, take medicine 15, symptom alleviates, and takes medicine 30, and arrhythmia reduces, and continues medication and consolidates for 6 months, cure, follow up a case by regular visits to 6 years, do not recur after clinical 1 year.

Example 3: Lee, male, 62 years old, have hypertension history, history of coronary heart disease 3 years, once because suffering from myocardial infarction died during hospitalization treatment, observe through thromboembolism treatment, leave hospital after two months, still have breast vexed, breathe hard, weak sign such as myocardial damage such as grade, patient's long-term bed, can not Go to ground activity, aggravation after slightly movable, electrocardiogram prompting old heart infarction, and serious S-T section changes, cardiac ultrasonic points out left room systolic and diastolic function seriously to go down, radiography shows coronary atherosclerosis, cause blood vessel Serious Stenosis, and apply PTCA, congestive heart failure III ° turns Chinese traditional treatment, cut out Western medicine, change and take medicine pill prepared in accordance with the present invention, use following formula:

Cortex Cinnamomi 25g, Rhizoma Zingiberis 25g, Radix Astragali 25g, Fructus Trichosanthis 20g, Radix Scutellariae 20g, Pericarpium Citri Reticulatae 20g, Radix Linderae 20g, Caulis Spatholobi 20g, Herba Lycopi 20g, Radix Codonopsis 20g, Cortex Eucommiae 15g, Semen Armeniacae Amarum 20g, Cacumen Platycladi 15g, Cortex Magnoliae Officinalis 15g, Herba Dendrobii 15g, Cortex Lycii 15g, Radix Glycyrrhizae 10g.

Make capsule to take.Daily three times, each four, add the treatment of heartbeat health simultaneously, after 50 days, patient symptom is clearly better. and after treating 5 months, electrocardiogram S-T section often changes correction, cardiac ultrasonic shows that Left ventricular systolic function is normal, continues to take sky consolidation half a year, does not recur so far after drug withdrawal.

Example 4: Shandong, male, 58 years old, History of Coronary Heart Disease 2 years, with angina pectoris, hypertension.Sign: have fever symptoms, still feel cardiopalmus after body temperature is normal, pulse speeds, and pareordia is uncomfortable, health fatigue and weak.Auxiliary examination: numeration of leukocyte raises, and electrocardiographic abnormality, myocardial damage ST-T changes, angina pectoris, arrhythmia, heart failure III °.Use following formula: Cortex Cinnamomi 22g, Rhizoma Zingiberis 22g, Radix Astragali 22g, Fructus Trichosanthis 18g, Radix Scutellariae 18g, Pericarpium Citri Reticulatae 18g, Radix Linderae 18g, Caulis Spatholobi 18g, Herba Lycopi 18g, Radix Codonopsis 18g, Cortex Eucommiae 12g, Semen Armeniacae Amarum 18g, Cacumen Platycladi 12g, Cortex Magnoliae Officinalis 12g, Herba Dendrobii 12g, Cortex Lycii 12g, Radix Glycyrrhizae 9g.

Be decocted in water for oral dose daily twice, through trimestral treatment, the state of an illness is stablized with becoming, but have slight cardiac dilatation, cardiac kinetic energy goes down, arrhythmia or ECG Change, then through the treatment of 3 months, patients symptomatic took a turn for the better gradually.

Data compare:

1.1 diagnosis and grade scales, heart failure is with reference to Framingham standard diagnostics, and cardiac functional grading performs with reference to USA New York heart disease association (NYHA) cardiac functional grading scheme.

1.2 include in and exclusion standard, clinical coronary heart disease of clarifying a diagnosis, hypertensive heart disease, pulmonary heart disease, dilated heart disease, rheumatic heart disease, the equal inclusive criteria scope of cardiac function III ~ IV level patient; Get rid of malignant tumor, pericarditis, acute myocardial infarction, liver and kidney failure, gestation and breast-feeding female patient.

1.3 physical data, all cases my institute internal medicine inpatient over nearly 3 years, all measures through clinical symptoms, sign, heart color doppler sonography, meets III ~ IV level, all cases is divided into treatment group and matched group at random by NYHA grade scale cardiac function.Treatment group 32 example, 50 ~ 75 years old age; Cardiac function III level 20 example, cardiac function IV level 12 example; Wherein coronary heart disease 15 example, hypertensive heart disease 10 example, pulmonary heart disease 5 example, dilated heart disease 1 example, rheumatic heart disease 1 example.Matched group 32 example, 55 ~ 75 years old age; Cardiac function III level 22 example, cardiac function IV level 10 example; Wherein coronary heart disease 14 example, hypertensive heart disease 10 example, pulmonary heart disease 6 example, dilated heart disease 1 example, rheumatic heart disease 1 example, two groups at age, the heart failure cause of disease, cardiac functional grading, sick to plant etc. through statistical procedures, no significant difference (P > 0.05), has comparability.

2 Therapeutic Method

2.1 matched groups, give conventional therapy, comprise rest, low sodium diet, oxygen uptake, oral diuretics, ACEI preparation (hydrochlorothiazide 25mg, spironolactone 20mg, captopril 25mg, equal every day 2 times), quiet motassium magnessium aspartate.Rapid heart rate person (110 times/min) interim intravenous injection cedilanid 0.4mg, furosemide 40mg, and give the cause of disease and Supporting Therapy of suiting the medicine to the illness.Some cases gives digoxin 0.125 ~ 0.25mg, and every day 1 time is oral, quiet sodium nitroprusside and treatment in dopamine if desired.

2.2 treatment groups, treatment of control group basis add and use treatment by Chinese herbs of the present invention.Every day 1 dose, decocting becomes 300ml, point 2 decoction being taken warmly.Two groups was all 1 course for the treatment of with 4 weeks.

2.3 observation index and method two groups treatment front and back itemized record are faced] bed symptom, sign and Minnesota investigation of life quality integration, adopt heart color doppler sonography to measure treatment changes of cardiac function and comprise the indexs such as SV, CO, CL, EF, all as Basic examination such as hepatic and renal functions before and after treatment, and observe untoward reaction.

2.4 statistical method enumeration datas adopt μ 2 standard, and measurement data adopts t inspection.

3 observation of curative effect

3.1 criterions of therapeutical effect: about the criterion of therapeutical effect of chronic heart failure is ordered in reference Ministry of Public Health " new Chinese medicine guideline of clinical investigations ".Effective: heart failure basic controlling, cardiac function improves more than 2 grades, and symptom and sign and every inspection obviously improve.Effective: cardiac function improves 1 grade, but not as good as 2 grades, symptom and sign and every inspection make moderate progress.Invalid: cardiac function improves not as good as 1 grade, even worsens.

3.2 therapeutic outcome

3.2.1 two groups of comparitive study, two groups of total effective rates compare, and difference has system

Meaning (P < 0.05) learned by meter, and treatment group curative effect is obviously better than matched group.

(see table 1)

Table 1 liang group comparitive study [example (%)]

Group	n	Effective	Effectively	Invalid	Total effective rate
						Treatment group	32	28(87.5)	3(9.3)	1(3.1)	31(96.9)a
Matched group	32	16(50)	11(34.3)	5(15.6)	27(84.4)

Note: two groups are compared, aP < 0.05

3.2.2 after before and after two groups of treatments, cardiac function compares two groups of treatments, cardiac function is more all improved with before treatment, and difference all has statistical significance (P < 0.01); After treatment, treatment group cardiac function compares improvement significantly (P < 0.01) with matched group.(see table 2)

Before and after table 2 liang group treatment, changes of cardiac function compares (x ± s)

Note: compare with before treatment of control group, aP > 0.05; Compare with after treatment of control group, P < 0.01, compare with before group internal therapy, cP < 0.05

3.2.3 two groups of untoward reaction are compared: occur nausea and vomiting 5 example in treatment of control group process, stop over digoxin, and alleviate after the treatment such as kalium replenishment, obvious adverse reaction does not appear in treatment group.

The present invention invigorates vital energy and reinforce the heart, invigorating spleen for diuresis, blood circulation promoting and blood stasis dispelling, has the function for the treatment of both the principal and secondary aspects of a disease, determined curative effect, Be very effective.Compared with prior art teach, the present invention has clear superiority: after use, has positive inotropic action to heart, strengthens myocardial contraction, and increase coronary artery blood flow, protecting myocardial cell, improves cardiac function.Obviously can improve the hemodynamics disturbance of patients with heart failure, improve cardiac function and left ventricular remodeling; Its mechanism may with to improve myocardial cell energy metabolism relevant.The present invention effectively can treat heart failure, corrects hemodynamics disturbance, and the cardiac function of the person that improves heart failure improves short term effect; Exhaustion cardiac muscle remodeling ventricle can be reversed, thus the long-term prognosis of the person that improves heart failure; Also prompting can prolonged application and non-evident effect.

Claims (5)

1. treat a Chinese medicine composition for heart failure, it is characterized in that, comprise the following component according to unit of weight configuration: Cortex Cinnamomi 20-30g, Rhizoma Zingiberis 20-30g, Radix Astragali 20-30g, Fructus Trichosanthis 15-25g, Radix Scutellariae 15-25g, Pericarpium Citri Reticulatae 15-25g, Radix Linderae 15-25g, Caulis Spatholobi 15-25g, Herba Lycopi 15-25g, Radix Codonopsis 15-25g, Cortex Eucommiae 10-20g, Semen Armeniacae Amarum 15-25g, Cacumen Platycladi 10-20g, Cortex Magnoliae Officinalis 10-20g, Herba Dendrobii 10-20g, Cortex Lycii 10-20g, Radix Glycyrrhizae 8-15g.

2. treat the Chinese medicine composition of heart failure according to claim 1, it is characterized in that, comprise the following component according to unit of weight configuration: Cortex Cinnamomi 20-25g, Rhizoma Zingiberis 20-25g, Radix Astragali 20-25g, Fructus Trichosanthis 15-20g, Radix Scutellariae 15-20g, Pericarpium Citri Reticulatae 15-20g, Radix Linderae 15-20g, Caulis Spatholobi 15-20g, Herba Lycopi 15-20g, Radix Codonopsis 15-20g, Cortex Eucommiae 10-15g, Semen Armeniacae Amarum 15-20g, Cacumen Platycladi 10-15g, Cortex Magnoliae Officinalis 10-15g, Herba Dendrobii 10-15g, Cortex Lycii 10-15g, Radix Glycyrrhizae 8-12g.

3. treat the Chinese medicine composition of heart failure according to claim 1, it is characterized in that, comprise the following component according to unit of weight configuration: Cortex Cinnamomi 25-30g, Rhizoma Zingiberis 25-30g, Radix Astragali 25-30g, Fructus Trichosanthis 20-25g, Radix Scutellariae 20-25g, Pericarpium Citri Reticulatae 20-25g, Radix Linderae 20-25g, Caulis Spatholobi 20-25g, Herba Lycopi 20-25g, Radix Codonopsis 20-25g, Cortex Eucommiae 15-20g, Semen Armeniacae Amarum 20-25g, Cacumen Platycladi 15-20g, Cortex Magnoliae Officinalis 15-20g, Herba Dendrobii 15-20g, Cortex Lycii 15-20g, Radix Glycyrrhizae 10-15g.

4. treat the Chinese medicine composition of heart failure according to claim 1, it is characterized in that, comprise the following component according to unit of weight configuration: Cortex Cinnamomi 22-28g, Rhizoma Zingiberis 22-28g, Radix Astragali 22-28g, Fructus Trichosanthis 18-22g, Radix Scutellariae 18-22g, Pericarpium Citri Reticulatae 18-22g, Radix Linderae 18-22g, Caulis Spatholobi 18-22g, Herba Lycopi 18-22g, Radix Codonopsis 18-22g, Cortex Eucommiae 12-18g, Semen Armeniacae Amarum 18-22g, Cacumen Platycladi 12-18g, Cortex Magnoliae Officinalis 12-18g, Herba Dendrobii 12-18g, Cortex Lycii 12-18g, Radix Glycyrrhizae 9-13g.

5. according to any one of Claims 1 to 4, treat a preparation method for the Chinese medicine composition of heart failure, it is characterized in that,

Dosage form is capsule, its preparation method comprises the following steps: described component is added weight 10 times amount ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 DEG C 1.08; Described filtrate flow is the macroporous adsorptive resins of 10L through volume, uses deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule.