CN117942374A - Traditional Chinese medicine composition for treating heart failure with cognitive dysfunction due to spleen deficiency and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating heart failure with cognitive dysfunction due to spleen deficiency and preparation method thereof Download PDFInfo
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- CN117942374A CN117942374A CN202311806675.0A CN202311806675A CN117942374A CN 117942374 A CN117942374 A CN 117942374A CN 202311806675 A CN202311806675 A CN 202311806675A CN 117942374 A CN117942374 A CN 117942374A
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- chinese medicine
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Abstract
The invention relates to a traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction, which comprises the following traditional Chinese medicine compositions in parts by weight: 18-22 parts of astragalus membranaceus, 8-12 parts of ginseng, 13-17 parts of bighead atractylodes rhizome, 13-17 parts of Chinese yam, 13-17 parts of poria cocos, 8-12 parts of rhizoma alismatis, 8-12 parts of rhizoma polygonati, 8-12 parts of Chinese angelica, 8-12 parts of ligusticum wallichii, 8-12 parts of radix ophiopogonis, 8-12 parts of rhizoma anemarrhenae, 5-7 parts of schisandra chinensis, 8-12 parts of dried orange peel, 5-7 parts of cassia twig, 8-12 parts of rhodiola rosea, 10-14 parts of cortex acanthopanacis and 5-7 parts of honey-fried licorice roots. The preparation method of the invention mainly comprises the steps of decoction and granulation. The invention is suitable for spleen deficiency symptoms such as listlessness, chest distress, asthma, short breath, edema, dizziness, palpitation, abdominal distension, anorexia, or cold feeling, weakness or thin stool, difficult urination, dull and dull feeling, slow and weak speech, depression and the like. Is especially suitable for patients with heart failure and cognitive dysfunction.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction and a preparation method thereof.
Background
Heart failure is a series of clinical syndromes caused by the progression of various heart diseases to the end-stage. Studies have shown that the prevalence of cognitive dysfunction can reach 20-80%, and that such patients have poor self-management and therapeutic compliance, with higher readmission and mortality.
At present, western medicine has no specific effective method for preventing and treating heart failure in further exploration of pathophysiological mechanisms of how to influence cognitive dysfunction.
In the traditional Chinese medicine, the heart failure belongs to the categories of heart water, suspended drink, edema, wheezing syndrome, heart distention and the like, and the differentiation of the heart failure in the traditional Chinese medicine is concentrated on yang deficiency and blood stasis syndrome, qi and yin deficiency and blood stasis syndrome.
Although a plurality of traditional Chinese medicines for treating heart failure are clinically based on the typing, few medicines for treating heart failure and cognitive dysfunction groups are available, and the prevention and treatment methods of heart failure and cognitive dysfunction diseases by traditional Chinese and western medicine are still continuously researched and developed.
Disclosure of Invention
The invention develops a traditional Chinese medicine composition for effectively treating heart failure with spleen deficiency syndrome and cognitive dysfunction and a preparation method thereof by taking a heart-spleen-brain co-disease mechanism of traditional Chinese medicine as a theoretical basis and through clinical practice observation and deep research.
The technical scheme of the invention is as follows:
In a first aspect, a traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following traditional Chinese medicine compositions in parts by weight: 18-22 parts of astragalus membranaceus, 8-12 parts of ginseng, 13-17 parts of bighead atractylodes rhizome, 13-17 parts of Chinese yam, 13-17 parts of poria cocos, 8-12 parts of rhizoma alismatis, 8-12 parts of rhizoma polygonati, 8-12 parts of Chinese angelica, 8-12 parts of ligusticum wallichii, 8-12 parts of radix ophiopogonis, 8-12 parts of rhizoma anemarrhenae, 5-7 parts of schisandra chinensis, 8-12 parts of dried orange peel, 5-7 parts of cassia twig, 8-12 parts of rhodiola rosea, 10-14 parts of cortex acanthopanacis and 5-7 parts of honey-fried licorice roots.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 20 parts of astragalus, 9 parts of ginseng, 15 parts of bighead atractylodes rhizome, 15 parts of Chinese yam, 15 parts of poria cocos, 10 parts of rhizoma alismatis, 9 parts of rhizoma polygonati, 9 parts of Chinese angelica, 9 parts of ligusticum wallichii, 10 parts of radix ophiopogonis, 9 parts of rhizoma anemarrhenae, 6 parts of schisandra chinensis, 10 parts of dried orange peel, 6 parts of cassia twig, 9 parts of rhodiola rosea, 12 parts of cortex acanthopanacis and 6 parts of honey-fried licorice root.
In a second aspect, a method for preparing a traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following steps:
(1) Weighing the traditional Chinese medicine composition according to the weight, adding water which is 8 times of the weight of the traditional Chinese medicine composition for decoction, performing primary decoction for 2 hours, and filtering to obtain filter residues and primary decoction;
(2) Adding water with the weight 8 times of that of the traditional Chinese medicine composition into the filter residue, decocting for the second time for 1.5 hours, filtering to obtain a second decoction, and combining the first decoction and the second decoction to obtain a filtrate;
(3) Standing the filtrate, taking supernatant, and concentrating under reduced pressure to obtain thick paste with the relative density of 1.3-1.4;
(4) Adding xylitol and dextrin, mixing, granulating, drying, and packaging.
Preferably, in step (3), the relative density is the density of the paste relative to 60 ℃ water.
Preferably, in the step (3), the temperature of the reduced pressure concentration is 60-80 ℃ and the pressure is 0.06-0.08 Mpa.
Preferably, in the step (4), the weight ratio of xylitol to dextrin to thick paste is 1:4:2.
The heart failure with cognitive dysfunction belongs to spleen deficiency syndrome.
The method comprises the following steps:
Radix astragali: sweet taste and slightly warm nature; enter spleen and lung meridians. Tonifying qi and strengthening spleen, raising yang and lifting sinking, tonifying defensive qi and consolidating superficial resistance, promoting urination and detumescence, expelling toxin and promoting granulation.
Ginseng: sweet and slightly bitter in flavor, slightly warm in nature, and enters spleen, lung and heart meridians. Greatly reinforcing primordial qi, reinforcing spleen, benefiting lung, promoting fluid production, soothing nerves and improving intelligence.
White atractylodes rhizome: sweet, bitter and warm. Has the effects of invigorating spleen and stomach meridian, replenishing qi to invigorate spleen, eliminating dampness and promoting diuresis.
Chinese yam: sweet and flat. Enter spleen, lung and kidney meridians. Replenishing qi, nourishing yin, and invigorating spleen, lung and kidney.
Poria cocos: sweet and bland in flavor, neutral in nature, and good in property, it enters heart, spleen and kidney meridians. Induce diuresis and excrete dampness, invigorate spleen and calm heart.
Oriental Waterplantain rhizome: sweet in flavor and cold in nature. Enter kidney and bladder meridians, induce diuresis and excrete dampness, and dispel heat.
Rhizoma polygonati: sweet and flat, enter spleen, lung and kidney meridians. Tonifying qi and yin, strengthening spleen, moistening lung and tonifying kidney.
Chinese angelica root: sweet and pungent in flavor, warm in nature, enter liver, heart and spleen meridians. Blood replenishing, menstruation regulating, blood activating and pain relieving; relaxing bowel.
Ligusticum wallichii: pungent and warm in nature. Enter liver, gallbladder and pericardium meridians. Promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain.
Radix Ophiopogonis: sweet and slightly bitter in flavor and slightly cold in nature. It enters stomach, lung and heart meridians. Nourishing yin, moistening lung, benefiting stomach, promoting fluid production, clearing heart fire and relieving restlessness.
Rhizoma anemarrhenae: bitter, sweet and cold. It enters lung, stomach and kidney meridians. Clear heat and purge fire, nourish yin and moisten dryness.
Chinese magnoliavine fruit: sour and sweet in taste and warm in nature. It enters lung, heart and kidney meridians. Astringing lung qi, invigorating qi, promoting fluid production, invigorating kidney, and calming heart.
Dried orange peel: pungent, bitter and warm. Enter spleen and lung meridians. Regulate qi, invigorate spleen, regulate middle energizer, dry dampness and resolve phlegm.
Ramulus Cinnamomi: pungent and sweet in flavor and warm in nature. It enters heart, lung and bladder meridians. Warm and unblock the channels and collaterals, strengthen yang and promote qi transformation.
Rhodiola rosea: sweet and cold. Enter spleen and lung meridians. Invigorating spleen, invigorating qi, clearing lung-heat, relieving cough, promoting blood circulation, and removing blood stasis.
Cortex Acanthopancis (Acanthopanax senticosus (Rupr. Et Maxim.) harms): pungent and bitter in flavor and warm in nature. Liver and kidney meridians. Dispelling wind-dampness, tonifying liver and kidney, strengthening tendons and bones, and inducing diuresis.
Honey-fried licorice root: sweet and flat. It enters heart, lung, spleen and stomach meridians. Tonify spleen and stomach, replenish qi and restore pulse, and harmonize various drugs.
The analysis of the prescription of the traditional Chinese medicine composition is as follows:
And (3) square solution: in the formula, astragalus root benefits qi, invigorates spleen, promotes urination and reduces swelling; ginseng can tonify primordial qi, tonify qi of heart, spleen, lung and kidney viscera, tranquilize mind and promote intelligence, and both herbs are used together as monarch drugs. Bai Zhu is good at tonifying qi to restore spleen and promote transportation, and also can remove dampness and promote diuresis, and it can strengthen the action of tonifying qi by combining with shan Yao for tonifying spleen, lung and kidney qi; poria cocos and rhizoma alismatis are used for promoting diuresis and removing dampness, and the three medicines are combined to further improve the functions of strengthening spleen and eliminating dampness and inducing diuresis and relieving swelling; rhizoma Polygonati has effects of nourishing yin, moistening lung, invigorating spleen, invigorating kidney, replenishing essence, and nourishing brain. The Chinese angelica has the effects of replenishing blood and activating blood, and the hemlock parsley has the effects of activating blood and promoting qi circulation to relieve pain, and the two have the effect of Wu Changda blood vessels; the above drugs are ministerial drugs. The adjuvant drug is radix ophiopogonis for nourishing yin and moistening lung, clearing heart fire and relieving restlessness; the schisandra chinensis has the effects of astringing lung, promoting fluid production, astringing and suppressing sweating; the two are matched with ginseng, and the ginseng can tonify and clear and astringe, so that the effect of promoting vital energy and dispersing is achieved, and the ginseng can not only tonify qi and nourish yin, but also recover the loss of qi and yin; rhizoma anemarrhenae is used for treating dryness-heat of radix astragali, tonifying qi without heat, and nourishing body fluid in lung; spleen deficiency and dampness obstructing middle energizer, clear yang not rising and turbid yin not falling, and pericarpium citri reticulatae are matched to regulate qi-flowing machine so as to assist lifting recovery, regulate qi and harmonize stomach, so that all medicines are supplemented without stagnation; ramulus Cinnamomi warms yang and transforms qi, and qi transformation causes water to self-flow, and also assists in promoting diuresis by promoting the flow of body fluid by promoting the circulation of the drugs Poria, alismatis rhizoma and Atractylodis rhizoma; cortex acanthopanacis has effects of warming kidney and promoting diuresis; rhodiola rosea has the effects of strengthening spleen, tonifying qi, promoting blood circulation and removing blood stasis. The honey-fried licorice root Gan Wenyi qi and the Chinese medicines in the harmonizing formula are auxiliary medicines, namely east wall cloud in the medical prescription test: radix astragali and Glycyrrhrizae radix can be added to give rise to qi surge. So it is also combined with Huang Qi, ren Shen, mai Dong and Wu Wei Zi to supplement qi. The above medicines are combined together to play the roles of replenishing qi to invigorate the spleen, activating blood and promoting diuresis.
The usage of the invention is as follows: orally taken 1 bag at a time, 10g in one bag, 2 times a day, and 14 days as a treatment course. It is recommended to take 4 courses of treatment or follow the doctor's advice.
The efficacy of the invention mainly treats: replenishing qi to invigorate the spleen, activating blood and promoting diuresis. The invention is suitable for spleen deficiency symptoms such as listlessness, chest distress, asthma, short breath, edema, dizziness, palpitation, abdominal distension, anorexia, or cold feeling, weakness or thin stool, difficult urination, dull and dull feeling, slow and weak speech, depression and the like. Is especially suitable for patients with heart failure and cognitive dysfunction.
Detailed Description
Example 1
A traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following traditional Chinese medicine compositions in parts by weight: 20 parts of astragalus, 9 parts of ginseng, 15 parts of bighead atractylodes rhizome, 15 parts of Chinese yam, 15 parts of poria cocos, 10 parts of rhizoma alismatis, 9 parts of rhizoma polygonati, 9 parts of Chinese angelica, 9 parts of ligusticum wallichii, 10 parts of radix ophiopogonis, 9 parts of rhizoma anemarrhenae, 6 parts of schisandra chinensis, 10 parts of dried orange peel, 6 parts of cassia twig, 9 parts of rhodiola rosea, 12 parts of cortex acanthopanacis and 6 parts of honey-fried licorice root.
A preparation method of a traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following steps:
(1) Weighing the traditional Chinese medicine composition according to the weight, adding water which is 8 times of the weight of the traditional Chinese medicine composition for decoction, performing primary decoction for 2 hours, and filtering to obtain filter residues and primary decoction;
(2) Adding water with the weight 8 times of that of the traditional Chinese medicine composition into the filter residue, decocting for the second time for 1.5 hours, filtering to obtain a second decoction, and combining the first decoction and the second decoction to obtain a filtrate;
(3) Standing filtrate, collecting supernatant, concentrating under reduced pressure of 0.08Mpa at 60deg.C to obtain soft extract with relative water density of 1.3; (4) Adding xylitol and dextrin, mixing, granulating, drying, and packaging.
Example 2
A traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following traditional Chinese medicine compositions in parts by weight: 18 parts of astragalus, 12 parts of ginseng, 14 parts of bighead atractylodes rhizome, 14 parts of Chinese yam, 14 parts of poria cocos, 8 parts of rhizoma alismatis, 10 parts of rhizoma polygonati, 10 parts of Chinese angelica, 10 parts of ligusticum wallichii, 8 parts of radix ophiopogonis, 10 parts of rhizoma anemarrhenae, 5 parts of schisandra chinensis, 11 parts of dried orange peel, 5 parts of cassia twig, 8 parts of rhodiola rosea, 10 parts of cortex acanthopanacis and 6 parts of honey-fried licorice root.
A preparation method of a traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following steps:
(1) Weighing the traditional Chinese medicine composition according to the weight, adding water which is 8 times of the weight of the traditional Chinese medicine composition for decoction, performing primary decoction for 2 hours, and filtering to obtain filter residues and primary decoction;
(2) Adding water with the weight 8 times of that of the traditional Chinese medicine composition into the filter residue, decocting for the second time for 1.5 hours, filtering to obtain a second decoction, and combining the first decoction and the second decoction to obtain a filtrate;
(3) Standing filtrate, collecting supernatant, concentrating under reduced pressure of 0.06Mpa at 80deg.C to obtain soft extract with relative water density of 1.4; (4) Adding xylitol and dextrin, mixing, granulating, drying, and packaging.
Example 3
A traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following traditional Chinese medicine compositions in parts by weight: 19 parts of astragalus root, 11 parts of ginseng, 13 parts of bighead atractylodes rhizome, 13 parts of Chinese yam, 13 parts of poria cocos, 9 parts of rhizoma alismatis, 11 parts of rhizoma polygonati, 11 parts of Chinese angelica, 11 parts of szechuan lovage rhizome, 9 parts of dwarf lilyturf tuber, 11 parts of rhizoma anemarrhenae, 7 parts of Chinese magnoliavine fruit, 12 parts of dried orange peel, 7 parts of cassia twig, 10 parts of rhodiola rosea, 11 parts of cortex acanthopanacis and 6 parts of honey-fried licorice root.
A preparation method of a traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following steps:
(1) Weighing the traditional Chinese medicine composition according to the weight, adding water which is 8 times of the weight of the traditional Chinese medicine composition for decoction, performing primary decoction for 2 hours, and filtering to obtain filter residues and primary decoction;
(2) Adding water with the weight 8 times of that of the traditional Chinese medicine composition into the filter residue, decocting for the second time for 1.5 hours, filtering to obtain a second decoction, and combining the first decoction and the second decoction to obtain a filtrate;
(3) Standing filtrate, collecting supernatant, concentrating under reduced pressure of 0.07Mpa at 70deg.C to obtain soft extract with relative water density of 1.4; (4) Adding xylitol and dextrin, mixing, granulating, drying, and packaging.
Example 4
A traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following traditional Chinese medicine compositions in parts by weight: 21 parts of astragalus, 10 parts of ginseng, 16 parts of bighead atractylodes rhizome, 16 parts of Chinese yam, 16 parts of poria cocos, 11 parts of rhizoma alismatis, 12 parts of rhizoma polygonati, 12 parts of Chinese angelica, 12 parts of ligusticum wallichii, 11 parts of radix ophiopogonis, 12 parts of rhizoma anemarrhenae, 6 parts of schisandra chinensis, 8 parts of dried orange peel, 6 parts of cassia twig, 11 parts of rhodiola rosea, 14 parts of cortex acanthopanacis and 7 parts of honey-fried licorice root.
A preparation method of a traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following steps:
(1) Weighing the traditional Chinese medicine composition according to the weight, adding water which is 8 times of the weight of the traditional Chinese medicine composition for decoction, performing primary decoction for 2 hours, and filtering to obtain filter residues and primary decoction;
(2) Adding water with the weight 8 times of that of the traditional Chinese medicine composition into the filter residue, decocting for the second time for 1.5 hours, filtering to obtain a second decoction, and combining the first decoction and the second decoction to obtain a filtrate;
(3) Standing filtrate, collecting supernatant, concentrating under reduced pressure of 75deg.C and 0.07Mpa to obtain soft extract with relative water density of 1.35;
(4) Adding xylitol and dextrin, mixing, granulating, drying, and packaging.
Example 5
A traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following traditional Chinese medicine compositions in parts by weight: 22 parts of astragalus root, 8 parts of ginseng, 17 parts of bighead atractylodes rhizome, 17 parts of Chinese yam, 17 parts of poria cocos, 12 parts of rhizoma alismatis, 8 parts of rhizoma polygonati, 8 parts of Chinese angelica, 8 parts of ligusticum wallichii, 12 parts of radix ophiopogonis, 8 parts of rhizoma anemarrhenae, 6 parts of schisandra chinensis, 9 parts of dried orange peel, 5 parts of cassia twig, 12 parts of rhodiola rosea, 13 parts of cortex acanthopanacis and 5 parts of honey-fried licorice root.
A preparation method of a traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction comprises the following steps:
(1) Weighing the traditional Chinese medicine composition according to the weight, adding water which is 8 times of the weight of the traditional Chinese medicine composition for decoction, performing primary decoction for 2 hours, and filtering to obtain filter residues and primary decoction;
(2) Adding water with the weight 8 times of that of the traditional Chinese medicine composition into the filter residue, decocting for the second time for 1.5 hours, filtering to obtain a second decoction, and combining the first decoction and the second decoction to obtain a filtrate;
(3) Standing filtrate, collecting supernatant, concentrating under reduced pressure of 0.065Mpa at 80deg.C to obtain soft extract with relative water density of 1.35;
(4) Adding xylitol and dextrin, mixing, granulating, drying, and packaging.
The efficacy of the application is demonstrated below in connection with the case.
The invention clinically applies a plurality of cases of medical records, and part of information is hidden to avoid leakage of patient information.
Case 1
A somebody, male, 74 years old.
The patient is admitted as the main reason of repeated chest distress and short breath for 2 months, aggravated palpitation for 1 day, and the standard treatment of heart failure is combined with the traditional Chinese medicine composition of the embodiment 1 to take medicine for 4 treatment courses. Orally taken 1 bag at a time, 10g in one bag, 2 times a day, and 14 days as a treatment course.
Admission diagnosis: coronary heart disease heart failure grade IV cardiac function
Symptoms at admission: repeated chest distress, short breath, aggravated after activity, palpitation, debilitation of the whole body, slow reaction, hypomnesis, no desire to eat or relieve constipation. A dark red tongue with white coating and a deep and rapid pulse
The admission index is as follows: BNP:2028pg/ml cardiac color Doppler ultrasound: EF28% FS13%. Liver function: 45.1U/L of aspartate transferase; kidney function is normal; cardiomyoenzymes: serum myoglobin 148.22ng/mL, creatine kinase isozymes were normal.
Montreal scoring scale: 20 minutes
Post-treatment symptoms: no chest distress, short breath, no palpitation, no debilitation of whole body, slow reaction, hypomnesis, anorexia improvement and normal stool. A dark red tongue with white coating and a deep pulse.
Recheck the index after treatment: BNP:836.2pg/ml heart color Doppler ultrasound: EF40% FS24%. Liver function: 42U/L of aspartate transferase; renal function: normal.
Montreal scoring scale: 22 minutes.
Case 2
B somebody, male, 59 years old.
The main factor is intermittent chest distress and pain for 10 months, aggravated palpitation for 3 days, and severe for even half a day, and the standard treatment of heart failure is combined with the traditional Chinese medicine composition of the example 1 to take medicine for 4 treatment courses. Orally taken 1 bag at a time, 10g in one bag, 2 times a day, and 14 days as a treatment course.
Admission diagnosis: coronary heart disease ischemic cardiomyopathy old myocardial infarction heart failure heart function IV grade
Symptoms at admission: chest distress and pain, palpitation, dizziness, short breath, general debilitation, heavy limbs, depression, restlessness, anorexia, thin stool and urine. A pale tongue with white coating and a deep and slippery pulse.
The admission index is as follows: BNP:521pg/ml heart color Doppler ultrasound: EF51% FS27%. Liver function: 10U/L of aspartate transferase, total protein: 58.4g/L albumin: 35.9g/L; renal function: serum urea 2.19mmol/L, blood β2 microglobulin: 0.96mg/L;
montreal scoring scale: 24 minutes
Post-treatment symptoms: the health-care food has the advantages of being clear in spirit, free of chest distress and pain, palpitation, dizziness, shortness of breath, hypodynamia and pain of the whole body, heavy in limbs and easy to receive and relieve the bowels normally. A pale tongue with white coating and a deep and slippery pulse.
Recheck the index after treatment: BNP:67pg/ml heart color Doppler ultrasound: e46F% FS23%. Liver function: aspartate transferase U/L; renal function: blood beta 2 microglobulin: 1.26mg/L.
Montreal scoring scale: 26 minutes.
Case 3
C somebody, female, 69 years old.
The main reason is repeated chest distress, short breath and debilitation for 10 months, aggravated for 1 week, and the standard treatment of heart failure is combined with the traditional Chinese medicine composition of the example 2 for 4 treatment courses. Orally taken 1 bag at a time, 10g in one bag, 2 times a day, and 14 days as a treatment course.
Admission diagnosis: coronary heart disease unstable angina pectoris heart failure heart function III grade
Symptoms at admission: repeated chest distress and shortness of breath, aggravated movement, palpitation, general lassitude and weakness, and qi deficiency and laziness in speaking can be achieved. A dark red tongue with white coating and a thready and slippery pulse.
The admission index is as follows: BNP:310.3pg/ml heart color Doppler ultrasound: EF%46FS%27. Liver function: albumin 38.7g/L; normal blood and kidney function.
Montreal scoring scale: 24 minutes
Post-treatment symptoms: it has the advantages of no chest distress, short breath, no palpitation, hypodynamia, less qi and no speaking. A dark red tongue with white coating and a thready and slippery pulse.
Recheck the index after treatment: BNP:79pg/ml heart color Doppler ultrasound): EF%58FS%. Liver function: aspartate transferase U/L; renal function: normal.
Montreal scoring scale: 26 minutes.
Case 4
D somebody, men, 60 years old.
The main reasons are repeated chest distress, short breath due to wheeze for 1 week, aggravated for 2 days, and hospital admission, and standard treatment of heart failure are combined with the traditional Chinese medicine composition of the example 2 for 4 treatment courses. Orally taken 1 bag at a time, 10g in one bag, 2 times a day, and 14 days as a treatment course.
Admission diagnosis: coronary heart disease acute ST elevation type myocardial infarction heart failure heart function IV level
Symptoms at admission: repeated chest distress and shortness of breath, aggravated movement, palpitation, general lassitude and weakness, and qi deficiency and laziness in speaking can be achieved. A dark red tongue with white and greasy coating and a slippery pulse.
The admission index is as follows: NT-ProBNP:7036.8pg/ml heart color Doppler ultrasound: EF%33FS%16. Liver function: 61.4g/L of total protein and 37.3g/L of albumin; the kidney functions normally.
Montreal scoring scale: 19 minutes
Post-treatment symptoms: it has the advantages of no chest distress, short breath, no palpitation, hypodynamia, less qi and no speaking.
Recheck the index after treatment: BNP:1800pg/ml heart color Doppler ultrasound: EF%53FS27%. Liver function: aspartate transferase U/L; renal function beta 2 microglobulin: 3.98mg/L.
Montreal scoring scale: 21 minutes.
Case 5
E somebody, male, 68 years old.
The main reason is that the patient is repeatedly chest stuffiness and short breath for 4 years, aggravated with palpitation for 1 week, and the standard treatment of heart failure is combined with the traditional Chinese medicine composition of the example 3 to take medicine for 4 treatment courses. Orally taken 1 bag at a time, 10g in one bag, 2 times a day, and 14 days as a treatment course.
Admission diagnosis: coronary heart disease unstable angina pectoris heart failure heart function III grade
Symptoms at admission: dull feeling, repeated chest distress, short breath, palpitation, less qi, no speaking, hiccup, acid regurgitation, and somnolence. A dark red tongue with a thin and white coating and a rapid pulse.
The admission index is as follows: BNP:746.1pg/ml heart color Doppler ultrasound: EF%38fs%18. Liver function: 64.8g/L total protein; renal function: beta 2 microglobulin 3.24mg/L.
Montreal scoring scale: 19 minutes
Post-treatment symptoms: the spirit can be used for treating chest distress, short breath, palpitation, less qi, no speaking, relieving, and the convenience. A dark red tongue with a thin and white coating and a rapid pulse.
Recheck the index after treatment: BNP:256.5pg/ml heart color Doppler ultrasound: EF%53FS27%. Liver function: 45.8U/L aspartate transferase, alanine aminotransferase: 53.2U/L, 59.6g/L total protein, 37.7g/L albumin; renal function beta 2 microglobulin: 3.05mg/L.
Montreal scoring scale: 21 minutes.
Case 6
F someone, men, age 69
The main factor is that the chest distress pain is sustained for 8 hours, the chest distress pain is aggravated for 5 hours, and the standard treatment of heart failure is combined with the traditional Chinese medicine composition of the example 3 to take medicine for 4 treatment courses. Orally taken 1 bag at a time, 10g in one bag, 2 times a day, and 14 days as a treatment course.
Admission diagnosis: coronary heart disease unstable angina pectoris heart failure heart function II grade
Symptoms at admission: the Chinese medicinal composition is characterized by listlessness, continuous chest distress and pain, slight feeling of shortness of breath, obvious sweats, hypodynamia, anorexia, poor sleep and the like in the prone position. A dark red tongue with white coating and a wiry and slippery pulse.
The admission index is as follows: BNP:181.9pg/ml heart color Doppler ultrasound: EF60% FS33%. Liver function: 54.4g/L of total protein of aspartate transferase; renal function: creatinine 53. Mu. Mmol/L;
montreal scoring scale: 25 minutes
Post-treatment symptoms: improved spirit, no chest distress and pain, no shortness of breath, no hypodynamia and perspiration, and easy sleep. A dark red tongue with white coating and a wiry and slippery pulse.
Recheck the index after treatment: BNP:56.5pg/ml heart color Doppler ultrasound: EF%64FS35%. Liver function: and 14.2U/L of aspartate transferase.
Montreal scoring scale: 26 minutes.
Case 7
G somewhere, male, 80 years old.
The patient is admitted for the patient who is mainly caused by intermittent chest distress and wheeze for 4 years and 1 month again, and the patient who is aggravated and cannot lie flat for 7 days, and the heart failure standard treatment is combined with the traditional Chinese medicine composition of the example 4 to take medicine for 4 treatment courses. Orally taken 1 bag at a time, 10g in one bag, 2 times a day, and 14 days as a treatment course.
Admission diagnosis: coronary heart disease unstable angina pectoris heart failure heart function IV grade
Symptoms at admission: the symptoms of listlessness, chest distress, shortness of breath, exacerbation during lying and activity, slight feeling and weakness, abdominal distension, anorexia, oliguria and stool. A dark red tongue with thin and white coating and a deep and thready pulse.
The admission index is as follows: NT-proBNP:35000pg/ml heart color Doppler ultrasound: EF%43fs%21. Liver function: total bilirubin 27.7 total protein 61.6g/L and albumin 32.7g/L; renal function: serum urea: 9.62mmol/L.
Montreal scoring scale: 19 minutes
Post-treatment symptoms: the health food has the advantages of improving spirit, relieving chest distress, shortness of breath, hypodynamia, abdominal distention, anorexia and increased quantity compared with the prior art. A dark red tongue with a thin and white coating and a rapid pulse.
Recheck the index after treatment: NT-proBNP:18000pg/ml heart color Doppler ultrasound: EF%48FS25%. Liver function: 44.5U/L of aspartate transferase and 37.7g/L of albumin; renal function: serum urea: 6.2mmol/L; .
Montreal scoring scale: 20 minutes.
Case 8
H is a female, 70 years old
The main reason is that the chest pain is sustained for 8 hours, and the standard treatment of heart failure is combined with the traditional Chinese medicine composition of the example 4, and the administration is carried out for 4 treatment courses. Orally taken 1 bag at a time, 10g in one bag, 2 times a day, and 14 days as a treatment course.
Admission diagnosis: coronary heart disease unstable angina pectoris heart failure heart function IV grade
Symptoms at admission: chest pain continues, chest distress, shortness of breath, inability to lie flat, listlessness, hypomnesis, anorexia, insomnia, and the like. A dark red tongue with a thin and white coating and a thready and rapid pulse.
The admission index is as follows: BNP:1594.9pg/ml heart color Doppler ultrasound: EF%55fs%29. Liver function: 50U/L of aspartate transferase; renal function: serum urea: 8.04mmol/L, creatinine 98. Mu. Mmol/L;
Montreal scoring scale: 22 minutes
Post-treatment symptoms: the Chinese medicinal composition has the advantages of no chest distress and chest pain, no shortness of breath, no palpitation, reduced debilitation of the whole body, hypomnesis, anorexia, poor sleep and the like. A dark red tongue with a thin and white coating and a thready and rapid pulse.
Recheck the index after treatment: BNP:326.7pg/ml heart color Doppler ultrasound: EF%55, FS29%. Liver function: 44.5U/L of aspartate transferase and 37.7g/L of albumin; renal function: serum urea: 11.36mmol/L and creatinine 105. Mu. Mmol/L.
Montreal scoring scale: 24 minutes.
Case 9
I somebody, men, 42 years old
The main reason is that the patient is admitted by repeated chest distress and wheeze for 10 years and 2 hours, and the standard treatment of heart failure is combined with the traditional Chinese medicine composition of the example 5 to take medicine for 4 treatment courses. Orally taken 1 bag at a time, 10g in one bag, 2 times a day, and 14 days as a treatment course.
Admission diagnosis: expanded heart disease heart failure class IV cardiac function
Symptoms at admission: chest distress, shortness of breath, sitting and breathing, dysphoria, depression, general debilitation, nausea, vomiting, edema of the lower extremities, poor appetite, oliguria, and constipation. A pale tongue with a thin and white coating and a deep and slippery pulse.
The admission index is as follows: BNP:1057.6pg/ml heart color Doppler ultrasound: EF%22fs%10. Liver function, kidney function: normal.
Montreal scoring scale: 25 minutes
Post-treatment symptoms: the Chinese medicinal composition has the advantages of no chest distress, short breath, debilitation, no dysphoria, no swelling of lower limbs, and no insomnia. A dark red tongue with a thin and white coating and a thready and rapid pulse.
Recheck the index after treatment: BNP:463.2pg/ml heart color Doppler ultrasound: EF%25 and FS12%. Liver function, kidney function: normal.
Montreal scoring scale: 28 minutes.
Case 10
J, female, age 78
The main reason is that the patient is admitted for chest distress and palpitation for 20 years, and the heart failure standard treatment is combined with the traditional Chinese medicine composition of the example 5 to take medicine for 4 treatment courses. Orally taken 1 bag at a time, 10g in one bag, 2 times a day, and 14 days as a treatment course.
Admission diagnosis: coronary heart disease heart failure grade IV cardiac function
Symptoms at admission: chest distress, palpitation, vexation, short breath, dizziness, slow and weak speech, poor sleep, unsmooth stool, dark urine, pale tongue, thin and white coating, and deep and thin pulse.
The admission index is as follows: BNP:3422pg/ml cardiac color Doppler ultrasound: EF%54fs%35. Renal function: creatinine 115 mu mmol/L; liver function: normal.
Montreal scoring scale: 21 minutes
Post-treatment symptoms: the Chinese medicinal composition has the advantages of no chest distress and palpitation, obviously reduced dysphoria, no shortness of breath and sweating, occasional dizziness, slow and weak speech, and easy sleep. A dark red tongue with a thin and white coating and a thready and rapid pulse.
Recheck the index after treatment: BNP:1200pg/ml heart color Doppler ultrasound: EF%58 and FS37%. Liver function, kidney function: normal.
Montreal scoring scale: 23 minutes.
The embodiments described above are only some, but not all, embodiments of the application. The following description of at least one exemplary embodiment is merely exemplary in nature and is in no way intended to limit the application, its application, or uses. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Claims (6)
1. The traditional Chinese medicine composition for treating heart failure with spleen deficiency syndrome and cognitive dysfunction is characterized by comprising the following traditional Chinese medicine composition in parts by weight: 18-22 parts of astragalus membranaceus, 8-12 parts of ginseng, 13-17 parts of bighead atractylodes rhizome, 13-17 parts of Chinese yam, 13-17 parts of poria cocos, 8-12 parts of rhizoma alismatis, 8-12 parts of rhizoma polygonati, 8-12 parts of Chinese angelica, 8-12 parts of ligusticum wallichii, 8-12 parts of radix ophiopogonis, 8-12 parts of rhizoma anemarrhenae, 5-7 parts of schisandra chinensis, 8-12 parts of dried orange peel, 5-7 parts of cassia twig, 8-12 parts of rhodiola rosea, 10-14 parts of cortex acanthopanacis and 5-7 parts of honey-fried licorice roots.
2. The traditional Chinese medicine composition for treating heart failure with spleen deficiency and cognitive dysfunction according to claim 1, which is characterized by comprising the following traditional Chinese medicine compositions in parts by weight: 20 parts of astragalus, 9 parts of ginseng, 15 parts of bighead atractylodes rhizome, 15 parts of Chinese yam, 15 parts of poria cocos, 10 parts of rhizoma alismatis, 9 parts of rhizoma polygonati, 9 parts of Chinese angelica, 9 parts of ligusticum wallichii, 10 parts of radix ophiopogonis, 9 parts of rhizoma anemarrhenae, 6 parts of schisandra chinensis, 10 parts of dried orange peel, 6 parts of cassia twig, 9 parts of rhodiola rosea, 12 parts of cortex acanthopanacis and 6 parts of honey-fried licorice root.
3. The preparation method of the traditional Chinese medicine composition for treating heart failure with spleen deficiency and cognitive dysfunction according to claim 1, which is characterized by comprising the following steps:
(1) Weighing the traditional Chinese medicine composition according to the weight, adding water which is 8 times of the weight of the traditional Chinese medicine composition for decoction, performing primary decoction for 2 hours, and filtering to obtain filter residues and primary decoction;
(2) Adding water with the weight 8 times of that of the traditional Chinese medicine composition into the filter residue, decocting for the second time for 1.5 hours, filtering to obtain a second decoction, and combining the first decoction and the second decoction to obtain a filtrate;
(3) Standing the filtrate, taking supernatant, and concentrating under reduced pressure to obtain thick paste with the relative density of 1.3-1.4;
(4) Adding xylitol and dextrin, mixing, granulating, drying, and packaging.
4. The method for preparing a Chinese medicinal composition for treating heart failure with cognitive dysfunction according to claim 3, wherein in the step (3), the relative density is the density of the thick paste relative to 60 ℃ water.
5. The method for preparing a Chinese medicinal composition for treating heart failure with cognitive dysfunction of spleen deficiency according to claim 3, wherein in the step (3), the temperature of the reduced pressure concentration is 60-80 ℃ and the pressure is 0.06-0.08 Mpa.
6. The method for preparing a traditional Chinese medicine composition for treating heart failure with spleen deficiency and cognitive dysfunction according to claim 3, wherein in the step (4), the weight ratio of xylitol to dextrin to thick paste is 1:4:2.
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