CN108403820A - It is a kind of to be used to treat Chinese medical extract of gastrointestinal disease and preparation method thereof - Google Patents
It is a kind of to be used to treat Chinese medical extract of gastrointestinal disease and preparation method thereof Download PDFInfo
- Publication number
- CN108403820A CN108403820A CN201810521972.3A CN201810521972A CN108403820A CN 108403820 A CN108403820 A CN 108403820A CN 201810521972 A CN201810521972 A CN 201810521972A CN 108403820 A CN108403820 A CN 108403820A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- rhizoma atractylodis
- extracts
- atractylodis macrocephalae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000284 extract Substances 0.000 title claims abstract description 129
- 208000018522 Gastrointestinal disease Diseases 0.000 title claims abstract description 39
- 208000010643 digestive system disease Diseases 0.000 title claims abstract description 35
- 208000018685 gastrointestinal system disease Diseases 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims abstract description 34
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 34
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims abstract description 34
- 229940010454 licorice Drugs 0.000 claims abstract description 34
- 244000197580 Poria cocos Species 0.000 claims abstract description 31
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 31
- 241000756943 Codonopsis Species 0.000 claims abstract description 30
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 30
- 238000000605 extraction Methods 0.000 claims abstract description 25
- 235000001188 Peltandra virginica Nutrition 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 241000218378 Magnolia Species 0.000 claims abstract description 16
- 241000202807 Glycyrrhiza Species 0.000 claims description 33
- 239000000843 powder Substances 0.000 claims description 27
- 239000000706 filtrate Substances 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 230000002829 reductive effect Effects 0.000 claims description 6
- 238000002137 ultrasound extraction Methods 0.000 claims description 6
- 238000001291 vacuum drying Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 235000019441 ethanol Nutrition 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 abstract description 23
- 210000002784 stomach Anatomy 0.000 abstract description 17
- 208000002193 Pain Diseases 0.000 abstract description 7
- 230000036407 pain Effects 0.000 abstract description 7
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 238000005728 strengthening Methods 0.000 abstract description 5
- 230000001079 digestive effect Effects 0.000 abstract description 3
- 208000005392 Spasm Diseases 0.000 abstract description 2
- 230000036737 immune function Effects 0.000 abstract description 2
- 230000007102 metabolic function Effects 0.000 abstract description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 208000007882 Gastritis Diseases 0.000 description 21
- 206010012735 Diarrhoea Diseases 0.000 description 20
- 201000010099 disease Diseases 0.000 description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 19
- 230000000694 effects Effects 0.000 description 14
- 208000024891 symptom Diseases 0.000 description 14
- 201000006549 dyspepsia Diseases 0.000 description 11
- 208000023652 chronic gastritis Diseases 0.000 description 10
- 208000007107 Stomach Ulcer Diseases 0.000 description 9
- 239000003814 drug Substances 0.000 description 9
- 208000000718 duodenal ulcer Diseases 0.000 description 9
- 201000005917 gastric ulcer Diseases 0.000 description 9
- 201000000117 functional diarrhea Diseases 0.000 description 8
- 210000004185 liver Anatomy 0.000 description 6
- 230000004048 modification Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 206010010774 Constipation Diseases 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 208000004880 Polyuria Diseases 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 230000000767 anti-ulcer Effects 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 230000007717 exclusion Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 230000007661 gastrointestinal function Effects 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 210000002460 smooth muscle Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 208000028774 intestinal disease Diseases 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 206010027175 memory impairment Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 208000018556 stomach disease Diseases 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- KSDSYIXRWHRPMN-UHFFFAOYSA-N 4'-O-beta-D-Galactopyranoside-6''-p-Coumaroylprunin-4',5,7-Trihydroxyflavanone Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC(O)=C3C(=O)C2)C=C1 KSDSYIXRWHRPMN-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000010470 Ageusia Diseases 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010016100 Faeces discoloured Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- DEMKZLAVQYISIA-ONJCETCRSA-N Liquiritin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)c1ccc([C@@H]2Oc3c(C(=O)C2)ccc(O)c3)cc1 DEMKZLAVQYISIA-ONJCETCRSA-N 0.000 description 1
- DEMKZLAVQYISIA-UHFFFAOYSA-N Liquirtin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-UHFFFAOYSA-N 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- IPVSUYLZIAYTOK-VWVAXHKFSA-O Peonin Natural products O(C)c1c(O)ccc(-c2c(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)cc3c(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)cc(O)cc3[o+]2)c1 IPVSUYLZIAYTOK-VWVAXHKFSA-O 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 208000020560 abdominal swelling Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 230000001147 anti-toxic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000021735 chronic enteritis Diseases 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- DEMKZLAVQYISIA-ZRWXNEIDSA-N liquiritin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C([C@H]2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-ZRWXNEIDSA-N 0.000 description 1
- -1 liquiritin) Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000001670 myorelaxant effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000009835 oxypaeoniflora Substances 0.000 description 1
- FCHVXNVDFYXLIL-QYDSDWLYSA-N oxypaeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@@]1(C[C@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=C(O)C=C1 FCHVXNVDFYXLIL-QYDSDWLYSA-N 0.000 description 1
- RLXWQODPAWIVOI-UHFFFAOYSA-N oxypaeoniflorin Natural products OCC1OC(OC23CC4C5(O)CC2OC(O5)C34COC(=O)c6ccc(O)cc6)C(O)C(O)C1O RLXWQODPAWIVOI-UHFFFAOYSA-N 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical group 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- GSZUGBAEBARHAW-UHFFFAOYSA-N sophoraflavone B Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C=2OC3=CC(O)=CC=C3C(=O)C=2)C=C1 GSZUGBAEBARHAW-UHFFFAOYSA-N 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Chinese medical extracts for treating gastrointestinal disease, prepare raw material and are grouped as by the group of following parts by weight：15~20 parts of licorice, 15~20 parts of radix paeoniae alba extraction, 15~20 parts of Magnolia cortex P.E, 15~20 parts of tuckahoe extracts, 6~12 parts of Rhizoma Atractylodis Macrocephalae extract, 6~12 parts of Radix Codonopsis extract, 6~12 parts of dried orange peel extracts.In addition, the present invention also provides a kind of preparation methods for treating the Chinese medical extract of gastrointestinal disease.The Chinese medical extract for the treatment of gastrointestinal disease provided by the invention is mutually acted synergistically with Radix Glycyrrhizae, Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Poria cocos, Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, dried orange peel achievees the purpose that vital energy regualting and blood circulation-promoting, dispersing stagnated hepatoqi, strengthening the spleen and stomach, relieving spasm and pain, increase digestive function improve immune and metabolic function.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medical extract and its system for treating gastrointestinal disease
Preparation Method.
Background technology
With social progress and development, people's living standard is continuously improved, and the food of fatness, sweet, thick and oily is largely taken in,
It is difficult to digest and assimilate, in addition the reasons such as pressure of undesirable living habit and work, easily causes the disease such as stomach of digestive system
Disease shows as losing the appetite, gasteremphraxis of having a stomachache, indigestion, abdominal pain, diarrhea, nausea and vomiting, digestive discomfort, and indigestion, god are tired
Weak, dizzy palpitaition, the symptoms such as insomnia forgetfulness bring great pain.Gastrointestinal disease, the system of actually many diseases
Claim.They have similar symptom, such as upper abdomen gastral cavilty portion discomfort, pain, glutted after meal, belch, acid reflux or even Nausea and vomiting etc.
Deng.Clinically common stomach trouble has acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer etc..Stomach trouble is compared in crowd
Common and refractory one of disease, some patient medical histories are even up to the more than ten years, and hospital and pharmacy all do not have this disease so far
There is specific drug.
It is extensive from promoting gastrointestinal peristalsis, improvement gastrointestinal function etc. to carry out both at home and abroad for the treatment of gastrointestinal disease
Research, but due to its mechanism complexity, and influenced by many factors, the therapy of doctor trained in Western medicine still compares limitation, there is no at present
The effective recovery gastrointestinal function of method as early as possible, and western medical treatment is palliative, the state of an illness is easy recurrence.Chinese medicine is warm-natured, stimulation
Property is small, easily effects a permanent cure.Therefore it provides a kind of Chinese medical extract for treating gastrointestinal disease, there is very important meaning.
Invention content
The present invention provides a kind of Chinese medical extracts for treating gastrointestinal disease, solve existing in the prior art ask
Topic.
The first purpose of the invention is to provide a kind of for treating the Chinese medical extract of gastrointestinal disease, prepare raw material by
The group of following parts by weight is grouped as：15~20 parts of licorice, 15~20 parts of radix paeoniae alba extraction, Magnolia cortex P.E 15~20
Part, 15~20 parts of tuckahoe extracts, 6~12 parts of Rhizoma Atractylodis Macrocephalae extract, 6~12 parts of Radix Codonopsis extract, 6~12 parts of dried orange peel extracts.
Preferably, the Chinese medical extract for treating gastrointestinal disease, prepares group of the raw material by following parts by weight
It is grouped as：18 parts of licorice, 18 parts of radix paeoniae alba extraction, 18 parts of Magnolia cortex P.E, 18 parts of tuckahoe extracts, Rhizoma Atractylodis Macrocephalae extract
9 parts, 9 parts of Radix Codonopsis extract, 9 parts of dried orange peel extracts.
Second object of the present invention is to provide a kind of preparation method for treating the Chinese medical extract of gastrointestinal disease, packet
Include following steps：
Step 1, licorice, radix paeoniae alba extraction, Mangnolia officinalis extract and tuckahoe extracts are prepared：
Radix Glycyrrhizae is smashed it through into 20~40 mesh sieve, obtains licorice powder, it is 5~8 times of licorice powder that weight is added into licorice powder
Mass concentration be 75~95% ethanol solution carry out ultrasonic extraction, carry out ultrafiltration after extract, collect filtrate, reduced pressure
It is 1.1~1.3,45 DEG C~75 DEG C vacuum drying to relative density, powder obtains licorice at fine powder；
Radix paeoniae alba extraction, Mangnolia officinalis extract, tuckahoe extracts are identical as the preparation method of licorice, and difference lies in will
Raw material replaces with Radix Paeoniae Alba, Mangnolia officinalis, Poria cocos respectively；
Step 2, Rhizoma Atractylodis Macrocephalae extract, Radix Codonopsis extract, dried orange peel extracts are prepared：
Rhizoma Atractylodis Macrocephalae is smashed it through into 20~40 mesh sieve, obtains Rhizoma Atractylodis Macrocephalae powder, the water logging that weight is 8~10 times is added into Rhizoma Atractylodis Macrocephalae powder
Bubble carries out first time heat after impregnating 0.5-2 hours and carries, extracts 1-2 hours, will carry for the first time at a temperature of 90~100 DEG C of heat carry
It takes liquid to filter, collects filtrate, 6~8 times of second of heat of water progress is added into filter residue and carries, at a temperature of 90~100 DEG C of heat carry
Second of extracting solution is filtered, collects filtrate by extraction 1-2 hours, filtrate will be merged twice, being concentrated under reduced pressure into relative density is
1.1~1.3,45 DEG C~75 DEG C vacuum drying, powder obtain Rhizoma Atractylodis Macrocephalae extract at fine powder；
Radix Codonopsis extract, dried orange peel extracts are identical as the preparation method of Rhizoma Atractylodis Macrocephalae extract, and difference lies in replace raw material respectively
It is changed to Radix Codonopsis, dried orange peel；
Step 3,15~20 parts of licorice, 15~20 parts of radix paeoniae alba extraction, Magnolia cortex P.E 15 are weighed by weight
~20 parts, 15~20 parts of tuckahoe extracts, 6~12 parts of Rhizoma Atractylodis Macrocephalae extract, 6~12 parts of Radix Codonopsis extract, dried orange peel extracts 6~12
Part, it is spare；
Step 4, licorice that step 3 weighs, radix paeoniae alba extraction, Magnolia cortex P.E, tuckahoe extracts, Rhizoma Atractylodis Macrocephalae are carried
Take object, Radix Codonopsis extract, dried orange peel extracts be uniformly mixed to get to it is described treatment gastrointestinal disease Chinese medical extract.
Preferably, the concrete operations of ultrasound extraction are in the step 1：At 40~50 DEG C, power is the condition of 200w
Lower ultrasonic extraction 30~60 minutes.
The performance of each raw material is as follows in the present invention：
Radix Glycyrrhizae；The active ingredient of Radix Glycyrrhizae is saponin(e (such as glycyrrhizic acid) and flavonoid glycoside (such as liquiritin), and two kinds of glycosides, are sweet
The Active regenerator of grass has Antiulcer activity effect, has spasmolysis to gastrointestinal smooth muscle, protects liver, promotes pancreas
Liquid is secreted.
Radix Paeoniae Alba：Its bitter, acid, cold nature, Return liver, the spleen channel, primary efficacy are smooth liver and relieve pain, nourishing blood for regulating menstruation, sword the moon hidroschesis.
Principle active component is glycoside such as Paeoniflorin, peonin, oxypaeoniflorin etc. in Radix Paeoniae Alba, has anti-inflammatory, anti-oxidant, immune adjust
, there are significant analgesia, calm, anticonvulsant action in the effects that section, anti-liver injury and fibrosis, wherein Paeoniflorin, to stomach
Intestinal smooth has spasmolysis, adjusts gastrointestinal smooth muscle normal contraction and diastole, there is antiulcer and hepatoprotective effect.In recent years
Pharmacological research shows that Radix Paeoniae Alba has many-sided pharmacological action such as anti-inflammatory, spasmolysis, analgesic, two-way immunological regulation of multi-path, clinical
For treating dysimmunity disease, body's immunity, Small side effects are adjusted.
Cortex Magnoliae Officinalis：It is warm-natured, it is bitter, pungent.Converge to the spleen channel, stomach, lung channel, large intestine channel.With control in humidity hysteresis wound, abdominal swelling and diarrhea, dyspepsia
The stagnation of the circulation of vital energy, abdominal distention constipation, sputum cough, heart spleen are uncomfortable, and kidney qi is weak, the pain and distention of the abdomen stool person of closing, stomach void diarrhea or just urinate gonorrhoea.Have
Myorelaxant effects, Small Dose Excitement intestinal tube smooth muscle, and large dosage is inhibited；Have the function of antiulcer, has aobvious
The central inhibitory action of work, blood pressure lowering, resisting pathogenic microbes are antitumor；Also antiplatelet and inhibition intracellular Ca2+ flowing etc.
Effect.
Poria cocos：Poria cocos slightly sweet flavor is flat, enters the heart, lung, the spleen channel.With clearing damp and promoting diuresis, strengthening the spleen and stomach, the work(of antitoxic heart-soothing and sedative
Effect is used for spleen eating less, confused and worried, insomnia of palpitating with fear etc..Poria cocos is mainly used for difficult urination, and oedema turgor, phlegm and retained fluid cough is inverse, vomits
It spits, spleen eating less, diarrhea, palpitation and restlessness, insomnia forgetfulness.It is mainly used for splenasthenic diarrhea, invigorating the spleen and can be oozed with lower Poria cocos
It is wet, under diarrhea caused by spleen deficiency dysfunction of the spleen in transportation and transformation, band, there is the benefits of strengthening the spleen and stomach.
Rhizoma Atractylodis Macrocephalae：Rhizoma Atractylodis Macrocephalae has the effect of invigorating the spleen tonifying Qi, eliminate dampness and have diuretic effect, hidroschesis tocolysis；Rhizoma Atractylodis Macrocephalae enters taste, can with air making-up and spleen enlivening,
Thus frequent deficiency of the spleen causing weakness of QI, dysfunction of the spleen in transportation and transformation, deficiency of food, loose stool or diarrhea crowd are very suitable；Rhizoma Atractylodis Macrocephalae also has the effect of eliminating dampness diuresis,
So can also be used under oedema, band, the symptoms such as skin eczema have the effect for the treatment of both manifestation and root cause of disease for damp-retention due to hypofunction of the spleen.Rhizoma Atractylodis Macrocephalae is used for
Weakness of the spleen and the stomach, deficiency of food turgor, the symptoms such as lassitude hypodynamia, loose stool diarrhea reinforce aid digestion tonifying spleen and stomach, the ruffian that disappears de-swelling, dampness removing and diarrhea-relieving
And other effects.
Radix Codonopsis：Radix Codonopsis has the work(of tonifying middle-Jiao and Qi, nourishing blood and tranquilization.The weakness of the spleen and the stomach person, taking Radix Codonopsis has preferable effect.Ancients
There is good summary to Radix Codonopsis：For invigorating the spleen fortune without dry, moistening lung grows stomach without cool without anti-cold and cool, blood-nourishing without dry, not only nourish but also
Blood-nourishing, and digestive system can also be balanced, it can be to promote the secretion of gastrointestinal disturbances and gastric juice, and stomach can also be prevented and burst
The generation of the gastrointestinal diseases such as ulcer.
Dried orange peel：A kind of common Chinese medicine of dried orange peel, have high medical value and health-care efficacy, have qi-regulating tune in, it is dry
Humidifying phlegm, can qi-regulating it is soothing the liver, it is drying damp and strengthening spleen, unclog and readjust that the taste stagnation of the circulation of vital energy, resolving sputum are wet, and dried orange peel can treat constipation, the unsmooth, halitosis of defecation etc.
Toxin is discharged in illness, gut purge.
Compared with prior art, the beneficial effects of the present invention are：
The Chinese medical extract for the treatment of gastrointestinal disease provided by the invention, synergistic effect is significant in efficacy, highly pushes greatly
Extensively.Play the role of coordination and complex treatment in the treatment, improves gastrointestinal function and achieve the purpose that rehabilitation.The present invention treats stomach and intestine disease
The Chinese medical extract of disease is mutually acted synergistically with Radix Glycyrrhizae, Radix Paeoniae Alba, Cortex Magnoliae Officinalis, Poria cocos, Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, dried orange peel to be reached vital energy regualting and blood circulation-promoting, dredges
Liver and qi, strengthening the spleen and stomach, relieving spasm and pain, increase digestive function improve immune and metabolic function purpose.
Specific implementation mode
In order to enable those skilled in the art to more fully understand, technical scheme of the present invention is practiced, with reference to specific
The invention will be further described for embodiment, but illustrated embodiment is not as a limitation of the invention.
The test method of actual conditions is not specified in following embodiments, according to the conventional method of this field and condition into
Row, if material used is commercially available without specified otherwise.
Embodiment 1
A kind of Chinese medical extract for treating gastrointestinal disease prepares raw material and is grouped as by the group of following parts by weight：
18 parts of licorice, 18 parts of radix paeoniae alba extraction, 18 parts of Magnolia cortex P.E, 18 parts of tuckahoe extracts, 9 parts of Rhizoma Atractylodis Macrocephalae extract, party
9 parts of conopsea extraction, 9 parts of dried orange peel extracts.
Specific preparation method is as follows：
Step 1, licorice, radix paeoniae alba extraction, Mangnolia officinalis extract and tuckahoe extracts are prepared：
Radix Glycyrrhizae is smashed it through into 30 mesh sieve, obtains licorice powder, it is dense that the quality that weight is 6 times of licorice powder is added into licorice powder
Degree carries out ultrasonic extraction for 95% ethanol solution, carries out ultrafiltration after having extracted, collects filtrate, being concentrated under reduced pressure into relative density is
1.1~1.3,65 DEG C of vacuum drying, powder obtain licorice at fine powder；
Radix paeoniae alba extraction, Mangnolia officinalis extract, tuckahoe extracts are identical as the preparation method of licorice, and difference lies in will
Raw material replaces with Radix Paeoniae Alba, Mangnolia officinalis, Poria cocos respectively；
Step 2, Rhizoma Atractylodis Macrocephalae extract, Radix Codonopsis extract, dried orange peel extracts are prepared：
Rhizoma Atractylodis Macrocephalae is smashed it through into 30 mesh sieve, obtains Rhizoma Atractylodis Macrocephalae powder, the water that weight is 9 times is added into Rhizoma Atractylodis Macrocephalae powder and impregnates, impregnates 1
First time heat is carried out after hour to carry, and is extracted 2 hours at a temperature of 100 DEG C of heat carry, first time extracting solution is filtered, collect filtrate,
6 times of second of heat of water progress is added into filter residue to carry, is extracted 1 hour at a temperature of 100 DEG C of heat carry, by second of extracting solution mistake
Filtrate is collected in filter, filtrate will be merged twice, it is 1.1~1.3,65 DEG C of vacuum drying to be concentrated under reduced pressure into relative density, and powder is at thin
Powder obtains Rhizoma Atractylodis Macrocephalae extract；
Radix Codonopsis extract, dried orange peel extracts are identical as the preparation method of Rhizoma Atractylodis Macrocephalae extract, and difference lies in replace raw material respectively
It is changed to Radix Codonopsis, dried orange peel；
Step 3,18 parts of licorice, 18 parts of radix paeoniae alba extraction, 18 parts of Magnolia cortex P.E, Poria cocos is weighed by weight to carry
18 parts of object, 9 parts of Rhizoma Atractylodis Macrocephalae extract, 9 parts of Radix Codonopsis extract, 9 parts of dried orange peel extracts are taken, it is spare；
Step 4, licorice that step 3 weighs, radix paeoniae alba extraction, Magnolia cortex P.E, tuckahoe extracts, Rhizoma Atractylodis Macrocephalae are carried
Take object, Radix Codonopsis extract, dried orange peel extracts be uniformly mixed to get to it is described treatment gastrointestinal disease Chinese medical extract.
Embodiment 2
A kind of Chinese medical extract for treating gastrointestinal disease, which is characterized in that it prepares raw material by following parts by weight
Group be grouped as：15 parts of licorice, 15 parts of radix paeoniae alba extraction, 15 parts of Magnolia cortex P.E, 15 parts of tuckahoe extracts, Rhizoma Atractylodis Macrocephalae carry
Take 12 parts of object, 12 parts of Radix Codonopsis extract, 12 parts of dried orange peel extracts.
The preparation method is the same as that of Example 1 for embodiment 2, the difference is that formula is different.
Embodiment 3
A kind of Chinese medical extract for treating gastrointestinal disease, which is characterized in that it prepares raw material by following parts by weight
Group be grouped as：20 parts of licorice, 20 parts of radix paeoniae alba extraction, 20 parts of Magnolia cortex P.E, 20 parts of tuckahoe extracts, Rhizoma Atractylodis Macrocephalae carry
Take 6 parts of object, 6 parts of Radix Codonopsis extract, 6 parts of dried orange peel extracts.
The preparation method is the same as that of Example 1 for embodiment 3, the difference is that formula is different.
Embodiment 4
A kind of Chinese medical extract for treating gastrointestinal disease, which is characterized in that it prepares raw material by following parts by weight
Group be grouped as：18 parts of licorice, 15 parts of radix paeoniae alba extraction, 20 parts of Magnolia cortex P.E, 15 parts of tuckahoe extracts, Rhizoma Atractylodis Macrocephalae carry
Take 12 parts of object, 9 parts of Radix Codonopsis extract, 10 parts of dried orange peel extracts.
The preparation method is the same as that of Example 1 for embodiment 5, the difference is that formula is different.Embodiment 5
A kind of Chinese medical extract for treating gastrointestinal disease, which is characterized in that it prepares raw material by following parts by weight
Group be grouped as：16 parts of licorice, 17 parts of radix paeoniae alba extraction, 18 parts of Magnolia cortex P.E, 19 parts of tuckahoe extracts, Rhizoma Atractylodis Macrocephalae carry
Take 7 parts of object, 8 parts of Radix Codonopsis extract, 9 parts of dried orange peel extracts.
The preparation method is the same as that of Example 1 for embodiment 5, the difference is that formula is different.
Examples 1 to 5 has prepared the Chinese medical extract of the treatment gastrointestinal disease to work well, is made below to the present invention
For the carry out clinical test of the Chinese medical extract gone out, to illustrate the effect of Examples 1 to 5.
One, clinical application
For a better understanding of the present invention, below by 500 clinical verifications of drug therapy chronic gastrointestinal diseases of the present invention
The advantageous effect of case summary the present invention is further explained Chinese medical extract.
1, research object
Patient 500, patient age 35-65 Sui are selected from out-patient.Wherein male is 250, and women is 250,
Age reckling 35 years old, the maximum 65 years old, average age is 50 years old, random to be grouped, the treatment stomach and intestine disease prepared using embodiment 1
The Chinese medical extract of disease, all cases are required to diet control during treatment, and participate in physical training appropriate.
Wherein, the gastrointestinal disease that patient suffers from includes following several：Functional diarrhea, functional dyspepsia FD are functional
Constipation, acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer.
2, diagnosis and exclusion criteria
The diagnostic criteria of Chinese medicine enterogastric diseases：With following clinical manifestations, epigastric distending pain, do not feel like eating, abdominal distention after meal,
Big loose stool is thin, limbs burnout, spitting blood, black stool, lusterless complexion, acid regurgitation, tongue are red, yellow tongue fur, floating and thready pulse.
The diagnostic criteria of doctor trained in Western medicine enterogastric diseases：It is related to doctor trained in Western medicine taste-blindness rate, acute or chronic gastritis (shallow, gruel
Rotten property, ginger contracting), acute chronic enteritis, the diseases such as gastrointestinal dysfunction press the newest diagnostic criteria execution of the disease.
Exclusion criteria：Merge liver, kidney, the heart, disease of hematopoietic system, mental patient and do not meet inclusion criteria, does not press rule
Fixed observation etc. that affects the treatment of taking medicine.
Each group case is comparable in gender, the course of disease, age distribution etc. there are no significant difference.
Instructions of taking：3 times a day, each 10g, before meals half an hour take, a month as a treatment course.
Two, efficacy assessment standard
It cures：Cardinal symptom and minor symptom are all eliminated, and physico-chemical examination restores normal.Integral reduces >=95%.
It is effective：Clinical cardinal symptom, minor symptom disappear substantially, and integral subtracts >=70%, and physico-chemical examination is obviously improved.
Effectively：Cardinal symptom, minor symptom mitigate, and integral reduces >=30%, and physico-chemical examination makes moderate progress.
In vain：Above-mentioned effective standard or deterioration person is not achieved without improvement in cardinal symptom, minor symptom.
Use the Chinese medical extract that gastrointestinal disease is treated in embodiment 1.After a course for the treatment of, the cardinal symptom of all patients
It is all eliminated with minor symptom, ulcer lesion or gastritis foci disappearance all meet the criterion of clinical recovery, and whole
Apparent adverse reaction is not observed during a treatment.And follow-up is carried out to patient weekly after treating a course for the treatment of, is held
Continuous half a year, do not find the sign of recurrence.
Three, treatment results
Table 1 is therapeutic effect of the Chinese medical extract to various enterogastric diseases that the embodiment of the present invention 1 treats gastrointestinal disease
| Treatment group | Case load | It cures | Significantly | Effectively | In vain | Total effective rate (%) |
| Functional diarrhea | 75 | 72 | 2 | 1 | 0 | 98.67 |
| Functional dyspepsia FD | 62 | 58 | 3 | 1 | 0 | 98.38 |
| Functional consitipation | 72 | 65 | 5 | 2 | 0 | 97.22 |
| Acute gastritis | 78 | 76 | 1 | 1 | 0 | 98.72 |
| Chronic gastritis | 67 | 60 | 5 | 2 | 0 | 97.01 |
| Gastric ulcer | 82 | 78 | 3 | 1 | 0 | 98.78 |
| Duodenal ulcer | 64 | 60 | 3 | 1 | 0 | 98.43 |
It summarizes analysis to the patient of 500 gastrointestinal diseases, the results showed that, during the embodiment of the present invention 1 is prepared
Medicament extract is directed to functional diarrhea, functional dyspepsia FD, functional consitipation, acute gastritis, chronic gastritis, gastric ulcer, ten
Two Duodenalulcers have significant curative effect, total effective rate to reach 97.01% or more.
This hair is expanded on further below by 500 clinical verification case summaries of drug therapy chronic gastrointestinal diseases of the present invention
Treatment advantageous effect of 2~5 Chinese medical extract of bright embodiment to various enterogastric diseases.Wherein, research object, diagnosis and exclusion
Standard, efficacy assessment standard are the same as above-described embodiment 1.
Table 2 is therapeutic effect of the Chinese medical extract to various enterogastric diseases that the embodiment of the present invention 2 treats gastrointestinal disease
| Treatment group | Case load | It cures | Significantly | Effectively | In vain | Total effective rate (%) |
| Functional diarrhea | 68 | 63 | 2 | 3 | 0 | 95.58 |
| Functional dyspepsia FD | 70 | 65 | 1 | 4 | 0 | 94.28 |
| Functional consitipation | 75 | 67 | 4 | 4 | 0 | 94066 |
| Acute gastritis | 72 | 68 | 2 | 2 | 0 | 97.22 |
| Chronic gastritis | 76 | 70 | 2 | 2 | 0 | 94.73 |
| Gastric ulcer | 85 | 74 | 3 | 7 | 1 | 90.58 |
| Duodenal ulcer | 54 | 50 | 2 | 2 | 0 | 96.30 |
Table 3 is therapeutic effect of the Chinese medical extract to various enterogastric diseases that the embodiment of the present invention 3 treats gastrointestinal disease
| Treatment group | Case load | It cures | Significantly | Effectively | In vain | Total effective rate (%) |
| Functional diarrhea | 70 | 66 | 1 | 3 | 0 | 95.71 |
| Functional dyspepsia FD | 65 | 60 | 1 | 4 | 0 | 92.30 |
| Functional consitipation | 74 | 70 | 1 | 3 | 0 | 95.94 |
| Acute gastritis | 80 | 76 | 1 | 2 | 1 | 96.25 |
| Chronic gastritis | 72 | 65 | 3 | 3 | 1 | 94.44 |
| Gastric ulcer | 77 | 70 | 3 | 4 | 0 | 94.80 |
| Duodenal ulcer | 62 | 56 | 2 | 4 | 0 | 93.55 |
Table 4 is therapeutic effect of the Chinese medical extract to various enterogastric diseases that the embodiment of the present invention 4 treats gastrointestinal disease
| Treatment group | Case load | It cures | Significantly | Effectively | In vain | Total effective rate (%) |
| Functional diarrhea | 79 | 71 | 5 | 3 | 0 | 96.20 |
| Functional dyspepsia FD | 68 | 60 | 3 | 4 | 1 | 92.64 |
| Functional consitipation | 80 | 73 | 3 | 5 | 0 | 95.00 |
| Acute gastritis | 71 | 68 | 1 | 2 | 0 | 98.72 |
| Chronic gastritis | 67 | 59 | 5 | 3 | 0 | 98.52 |
| Gastric ulcer | 74 | 68 | 3 | 2 | 1 | 95.94 |
| Duodenal ulcer | 61 | 56 | 2 | 3 | 0 | 95.08 |
Table 5 is therapeutic effect of the Chinese medical extract to various enterogastric diseases that the embodiment of the present invention 5 treats gastrointestinal disease
| Treatment group | Case load | It cures | Significantly | Effectively | In vain | Total effective rate (%) |
| Functional diarrhea | 80 | 72 | 5 | 3 | 0 | 96.25 |
| Functional dyspepsia FD | 58 | 52 | 2 | 4 | 0 | 93.10 |
| Functional consitipation | 70 | 64 | 2 | 4 | 0 | 94.28 |
| Acute gastritis | 81 | 75 | 1 | 4 | 1 | 92.59 |
| Chronic gastritis | 71 | 64 | 1 | 6 | 0 | 91.55 |
| Gastric ulcer | 76 | 70 | 2 | 4 | 0 | 94.73 |
| Duodenal ulcer | 64 | 58 | 2 | 4 | 0 | 93.75 |
The Chinese medical extract that the embodiment of the present invention 2~5 is prepared is directed to functional diarrhea, functional dyspepsia FD, work(
Energy property constipation, acute gastritis, chronic gastritis, gastric ulcer, the treatment of duodenal ulcer are effective, and total effective rate reaches 91.55%
More than.
It should be noted that involved in claims of the present invention when numberical range, it is thus understood that each numberical range
Any one numerical value can be selected between two endpoints and two endpoints, due to step method and the Examples 1 to 5 phase of use
Together, it repeats in order to prevent, description of the invention preferred embodiment, once a person skilled in the art knows basic
Creative concept, then additional changes and modifications may be made to these embodiments.It is wrapped so the following claims are intended to be interpreted as
It includes preferred embodiment and falls into all change and modification of the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
God and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (4)
1. a kind of Chinese medical extract for treating gastrointestinal disease, which is characterized in that it prepares raw material by following parts by weight
Group is grouped as：15~20 parts of licorice, 15~20 parts of radix paeoniae alba extraction, 15~20 parts of Magnolia cortex P.E, tuckahoe extracts
15~20 parts, 6~12 parts of Rhizoma Atractylodis Macrocephalae extract, 6~12 parts of Radix Codonopsis extract, 6~12 parts of dried orange peel extracts.
2. according to claim 1 for treating the Chinese medical extract of gastrointestinal disease, which is characterized in that its prepare raw material by
The group of following parts by weight is grouped as：18 parts of licorice, 18 parts of radix paeoniae alba extraction, 18 parts of Magnolia cortex P.E, Poria cocos extraction
18 parts of object, 9 parts of Rhizoma Atractylodis Macrocephalae extract, 9 parts of Radix Codonopsis extract, 9 parts of dried orange peel extracts.
3. the preparation method according to claim 1 for treating the Chinese medical extract of gastrointestinal disease, which is characterized in that packet
Include following steps：
Step 1, licorice, radix paeoniae alba extraction, Mangnolia officinalis extract and tuckahoe extracts are prepared：Radix Glycyrrhizae is smashed it through 20~
40 mesh sieve, and obtain licorice powder, and into licorice powder, addition weight is the ethyl alcohol that the mass concentration of 5~8 times of licorice powder is 75~95%
Solution carries out ultrasonic extraction, carries out ultrafiltration after having extracted, collects filtrate, and it is 1.1~1.3,45 DEG C to be concentrated under reduced pressure into relative density
~75 DEG C of vacuum drying, powder obtain licorice at fine powder；
Radix paeoniae alba extraction, Mangnolia officinalis extract, tuckahoe extracts are identical as the preparation method of licorice, and difference lies in by raw material
Radix Paeoniae Alba, Mangnolia officinalis, Poria cocos are replaced with respectively；
Step 2, Rhizoma Atractylodis Macrocephalae extract, Radix Codonopsis extract, dried orange peel extracts are prepared：Rhizoma Atractylodis Macrocephalae is smashed it through into 20~40 mesh sieve, is obtained
Rhizoma Atractylodis Macrocephalae powder, the water that weight is 8~10 times is added into Rhizoma Atractylodis Macrocephalae powder and impregnates, and carrying out first time heat after impregnating 0.5-2 hours carries, 90
~100 DEG C of heat are extracted 1-2 hours at a temperature of carrying, and first time extracting solution is filtered, and collect filtrate, and 6~8 times are added into filter residue
Water carries out second of heat and carries, and is extracted 1-2 hours at a temperature of 90~100 DEG C of heat carry, and second of extracting solution is filtered, filter is collected
Liquid filtrate will merge twice, and it is 1.1~1.3,45 DEG C~75 DEG C vacuum drying to be concentrated under reduced pressure into relative density, and powder is obtained at fine powder
To Rhizoma Atractylodis Macrocephalae extract；
Radix Codonopsis extract, dried orange peel extracts are identical as the preparation method of Rhizoma Atractylodis Macrocephalae extract, and difference lies in replace with raw material respectively
Radix Codonopsis, dried orange peel；
Step 3,15~20 parts of licorice, 15~20 parts of radix paeoniae alba extraction, Magnolia cortex P.E 15~20 are weighed by weight
Part, 15~20 parts of tuckahoe extracts, 6~12 parts of Rhizoma Atractylodis Macrocephalae extract, 6~12 parts of Radix Codonopsis extract, 6~12 parts of dried orange peel extracts,
It is spare；
Step 4, licorice, radix paeoniae alba extraction, Magnolia cortex P.E, tuckahoe extracts, Rhizoma Atractylodis Macrocephalae step 3 weighed extracts
Object, Radix Codonopsis extract, dried orange peel extracts be uniformly mixed to get to it is described treatment gastrointestinal disease Chinese medical extract.
4. the preparation method according to claim 3 for treating the Chinese medical extract of gastrointestinal disease, which is characterized in that institute
Stating the concrete operations that ultrasound extracts in step 1 is：At 40~50 DEG C, power is 30~60 points of ultrasonic extraction under conditions of 200w
Clock.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810521972.3A CN108403820A (en) | 2018-05-28 | 2018-05-28 | It is a kind of to be used to treat Chinese medical extract of gastrointestinal disease and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810521972.3A CN108403820A (en) | 2018-05-28 | 2018-05-28 | It is a kind of to be used to treat Chinese medical extract of gastrointestinal disease and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108403820A true CN108403820A (en) | 2018-08-17 |
Family
ID=63140603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810521972.3A Pending CN108403820A (en) | 2018-05-28 | 2018-05-28 | It is a kind of to be used to treat Chinese medical extract of gastrointestinal disease and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108403820A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111789920A (en) * | 2020-07-14 | 2020-10-20 | 王惠武 | Immunity function conditioning electuary |
| CN112006236A (en) * | 2020-07-14 | 2020-12-01 | 南北兄弟药业投资有限公司 | Meat food for children |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430999A (en) * | 2003-01-28 | 2003-07-23 | 南京师范大学 | Chinese herbal medicine combination for treating disease of disorder of bowels's function and its product |
| KR20060099573A (en) * | 2005-03-14 | 2006-09-20 | 윤용지 | How to making grastric cancer treatment function food |
| CN106266112A (en) * | 2016-11-17 | 2017-01-04 | 中悦民安（北京）科技发展有限公司 | A kind of compound Chinese medicinal preparation of invigorating the spleen to arrest diarrhea and preparation method thereof |
-
2018
- 2018-05-28 CN CN201810521972.3A patent/CN108403820A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430999A (en) * | 2003-01-28 | 2003-07-23 | 南京师范大学 | Chinese herbal medicine combination for treating disease of disorder of bowels's function and its product |
| KR20060099573A (en) * | 2005-03-14 | 2006-09-20 | 윤용지 | How to making grastric cancer treatment function food |
| CN106266112A (en) * | 2016-11-17 | 2017-01-04 | 中悦民安（北京）科技发展有限公司 | A kind of compound Chinese medicinal preparation of invigorating the spleen to arrest diarrhea and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 吴士元等: "慢性胃炎消化性溃疡治疗点滴", 《黑龙江中医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111789920A (en) * | 2020-07-14 | 2020-10-20 | 王惠武 | Immunity function conditioning electuary |
| CN112006236A (en) * | 2020-07-14 | 2020-12-01 | 南北兄弟药业投资有限公司 | Meat food for children |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102068707B (en) | Traditional Chinese medicine contrast medium adjuvant used for B ultrasonic and preparation method thereof | |
| CN102198262B (en) | Chinese medicine preparation for treating infant rotavirus enteritis and preparation method thereof | |
| CN106822766A (en) | A kind of traditional Chinese medicinal components of clearing damp invigorating the spleen and preparation method thereof | |
| CN101716318B (en) | Traditional Chinese medicine preparation for treating tumor of digestive system | |
| CN103386100B (en) | Autumn diarrhea paste | |
| CN108403820A (en) | It is a kind of to be used to treat Chinese medical extract of gastrointestinal disease and preparation method thereof | |
| CN108704108A (en) | A kind of medicine pill for treating gout | |
| CN104162129A (en) | Traditional Chinese medicine for treating diabetic gastroparesis | |
| CN109730981A (en) | For treating anorexia, dyspeptic Traditional Chinese medicine composition patch, preparation and its application | |
| CN109771602A (en) | For treating external application type Traditional Chinese medicine composition patch, preparation and its application of diarrhea | |
| CN108653432A (en) | A kind of Chinese medicine composition and its preparation | |
| CN103977379A (en) | Traditional Chinese medicine preparation for treating bile reflux gastritis | |
| CN102988952B (en) | Umbilicus-applied nursing cream for preventing uroschesis of infant accepting surgical operation | |
| CN104383403A (en) | Traditional Chinese medicinal composition for treating chronic gastritis | |
| CN109125647A (en) | A kind of gastrointestinal mucosa repairs liquid and preparation method thereof | |
| CN103110783A (en) | Medicine for treating encephalatrophy | |
| CN107596327A (en) | A kind of medicine for treating intermingling cold and heat functional dyspepsia FD | |
| CN114796434A (en) | Pill for keeping healthy qi and pathogenic factors dry | |
| CN105596947A (en) | Pharmaceutical composition used for treating chronic gastritis | |
| CN105311613A (en) | Traditional Chinese medicine oral solution for treating chronic gastritis and preparation method | |
| CN105748674A (en) | External traditional Chinese medicine powder for treating infantile diarrhea | |
| CN104645247A (en) | Traditional Chinese medicine preparation for treating hepatolenticular degeneration and preparation method of traditional Chinese medicine preparation | |
| CN115634265A (en) | Traditional Chinese medicine composition for clearing damp and conditioning damp-heat constitution and medicated diet thereof | |
| CN117138007A (en) | Traditional Chinese medicine composition for treating helicobacter pylori and preparation method thereof | |
| CN116196350A (en) | Traditional Chinese medicine combination preparation for treating ulcerative colitis and peptic ulcer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180817 |
|
| RJ01 | Rejection of invention patent application after publication |