CN103110783A - Medicine for treating encephalatrophy - Google Patents

Medicine for treating encephalatrophy Download PDF

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Publication number
CN103110783A
CN103110783A CN2013100313073A CN201310031307A CN103110783A CN 103110783 A CN103110783 A CN 103110783A CN 2013100313073 A CN2013100313073 A CN 2013100313073A CN 201310031307 A CN201310031307 A CN 201310031307A CN 103110783 A CN103110783 A CN 103110783A
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parts
medicine
effect
radix
treatment
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阮彩莲
韩继明
王璐
许正龙
杨文芳
梅冬
千超
武涛
王战英
何晓
谷秀娟
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Yanan University
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Yanan University
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Abstract

The invention relates to a medicine for treating encephalatrophy. The medicine is prepared from the raw materials in parts by weight through decocting with water: 10 parts of human placenta, 10 parts of longan aril, 10 parts of mulberry, 10 parts of red and white paeony root, 10 parts of radix pseudostellariae, 10 parts of Indian buead, 10 parts of acorus gramineus, 10 parts of salvia miltiorrhiza, 15 parts of Chinese angelica, 15 parts of pollen typhae, 12 parts of polygala tenuifolia, 12 parts of tulip, 20 parts of rehmannia glutinosa and 6 parts of scandent hop. According to the clinical application, the traditional Chinese medicine has the effect of treating encephalatrophy of elderly people, can perform syndrome differentiation, simultaneously treat principal and subordinate symptoms and regulate the internal organs aiming at the pathogenesis, can nourish brain cells and promote brain tissue development and is obvious in curative effect and does not have a toxic or side effect compared with the Western medicine.

Description

A kind of medicine for the treatment of brain atrophy
Technical field
The present invention relates to a kind of medicine for the treatment of brain atrophy.
Background technology
Brain atrophy is the corresponding minimizing of a kind of brain tissue cell and cause the disease of cranial nerve function imbalance, and brain atrophy is dull-witted in clinical topmost symptom, especially old people Yi Yinqi senile dementia.Brain atrophy is to be caused a kind of mental deterioration disease of cerebral tissue volume-diminished by many reasons, how caused atrophy, distortion, the disappearances of brain essence destruction and neurocyte by heredity, cerebral trauma, cerebral infarction, encephalitis, cerebral ischemia, anoxia, cerebral arteriosclerosis, carbon monoxide poisoning, alcoholism etc., wherein topmost paathogenic factor is cerebrovascular long-term chronic ischemia and causing.The Therapeutic Principle of brain atrophy has multiple, if early discovery, early treatment easily obtains curative effect preferably.The means of generally using clinically Comprehensive Treatment to the patient carry out comprehensive, diversified Comprehensive Treatment, except treating for the dyskinesia, the aphasis that is combined, mental retardation, dystropy, epilepsy also will be treated, but effect is but not as people's will.
Summary of the invention
A kind of medicine for the treatment of brain atrophy provided by the invention, it is characterized in that: it is made by the crude drug of following weight parts: 6 parts of 10 parts of Placenta Hominiss, 10 parts of Arillus Longans, 10 parts of Fructus Mori, 10 parts of the red Radix Paeoniae Albas, 10 parts of Radix Pseudostellariaes, 10 parts, Poria, 10 parts of Rhizoma Acori Graminei, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Pollen Tyjphae, 12 parts of Radix Polygalaes, 12 parts of Flos Tulipae Gesnerianaes, 20 parts, Radix Rehmanniae Preparata and Herba humuli scandentis.
Each crude drug pharmacodynamic analysis is as follows:
Placenta Hominis (human placenta): sweet salty, warm.QI invigorating nourishes blood, the benefit essence.Cure mainly: the disease such as deficient, weakness and emaciation, hemoptysis asthma, consumptive fever hectic fever due to YIN-deficiency, seminal emission.Function: 1. enhancing body resistance effect; 2. anti-infectious function; 3. hormone-like effect; 4. on the impact of blood clotting, can stable fibers albumen grumeleuse, promote wound healing; Clinical practice 1. treatment bronchial asthmas; 2. treatment chronic tracheitis; 3. treatment skin ulcer; 4. treat the breast milk deficiency disease.
Arillus Longan (longan aril): nature and flavor are warm in nature, distinguish the flavor of sweet.Invigorating the heart and spleen, nourishing blood to tranquillize the mind.Be used for insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.Main effect: 1. vigorate qi and replenish the blood, hypermnesis; 2. tranquilizing the mind; 3. nourishing blood and preventing abortion; 4. antibiotic, anticancer; 5. the heart is protected in blood fat reducing, slow down aging.
Fructus Mori (mulberry): feeble QI, the little acid and sweet of distinguishing the flavor of.Sweet, sour, cold.GUIXIN, liver, kidney channel.The YIN nourishing of enriching blood is promoted the production of body fluid and is moisturized.Be used for vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.Tonifying liver, kidney tonifying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.1. enhancing immunologic function can strengthen the weight of immune organ; 2. on the impact of Na+, K+-ATP enzymatic activity; 3. can strengthen the nonspecific immunity function; 4. humoral immunization there is increasing action; 5. the cell-mediated immunologic function of T there is significant facilitation; 6. cell mutation had preventive effect; 7. have the effect of anti-hepatitis B virus and the effect of anti-AIDS.
The red Radix Paeoniae Alba (Red radix paeoniae alba): the Radix Paeoniae Rubra abnormal smells from the patient is bitter flat, nontoxic.Cure mainly pathogen stomachache, broken hard long-pending except arthralgia due to stagnation of blood, cold and heat, sick tired, pain relieving, diuresis, QI invigorating.
Radix Pseudostellariae (heterophylly falsestarwort root): contain the abundant trace element such as Fe, Cu, Zn, Cr, Ni, Co, Sr, Mn, Pb, Li, Na, B, Be, Ti, Al, Ca, Mg, K, P, Se, wherein Fe, Cu, Zn, Cr, Ni, Co, Sr, Mn, Na, B, Ca, Mg, K, P, Se are the indispensable element of human body, content with Fe, Cu, Zn, Mn is higher according to one's analysis, and Pb is harmful element.Sweet, little hardship, tepor; Qi-restoratives medicine, Qi-tonifying drug; Mend strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Control the cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus, palpitation with a distress feeling, edema is quenched one's thirst, and spirit is tired.
Poria (Indian bread): the Poria slightly sweet flavor is flat, enters the heart, lung, spleen channel.Has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can control dysuria, the edema distension, the phlegm retention cough with dyspnea, vomiting, malignant histocytosis is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.Clinical practice: 1. be used for dysuria, disease Poria function promoting diuresis to eliminate damp pathogen such as edema, and the property of medicine is gentle, diuretic and do not hinder healthy energy is the promoting diuresis to eliminate damp pathogen key medicine; 2. be used for diarrhea due to hypofunction of the spleen, the leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, for have loose bowels due to insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, use the effect that Poria has giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as again the tonifying the lung spleen, control the adjuvant of the deficiency of vital energy; 3. be used for cough due to fluid-retention, phlegm-damp enters network, and the aching pain in should and back Poria can promoting diuresis to eliminate damp pathogen, has again a function of invigorating spleen, for insufficiency of the spleen can not transmitting and distributing the fluids, stop the disease that phlegm retention is given birth in dimerization, have therapeutical effect; 4. be used for cardiopalmus, insomnia waits the disease Poria can tranquilizing by nourishing the heart, thus can be used for the diseases such as irritability, cardiopalmus, insomnia, often and the compatibilities such as Radix Ginseng, Radix Polygalae, Semen Ziziphi Spinosae; 5. anticancer.
Rhizoma Acori Graminei (grassleaf sweetflag rhizome): hot, bitter, temperature.GUIXIN, stomach warp.The removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.1. to central nervous system's effect, can convulsion, cooling; 2. to the effect of cardiovascular system, can blood vessel dilating, calm, improve digestive function, relieving asthma, the effect such as antitussive is relevant; 3. to the effect of digestive system, the secretion of facilitating digestion liquid and prevent gastrointestinal abnormal fermentation, and the effect of alleviating the intestinal tube smooth muscle spasm is arranged; 4. antifungic action has in various degree inhibitory action to various funguses.
Radix Salviae Miltiorrhizae (Salvia miltiorrhiza): hardship is slightly cold; Enter the heart, Liver Channel.Cure mainly menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Major function: 1. the effect of cardiovascular system, can heart tonifying, coronary artery dilating, increase myocardial flow, antithrombotic form, improve microcirculation, promote tissue reparation and regeneration, protect the liver, effect for reducing blood fat.
Radix Angelicae Sinensis (Chinese angelica): warm in nature, sweet in the mouth, suffering.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores with control the apoplexy syncope, spit out white foams, puerperal paralysis.1. oxygen lack resistant function; 2. regulate body's immunity, have antitumaous effect; 3. cosmetology effect; 4. the effect of invigorating blood circulation of enriching blood; 5. antibacterial, arteriosclerosis effect.
Pollen Tyjphae (Born cattail pollen): Gan Xin is cool.Enter liver, heart channel.1. to the effect in uterus, Pollen Typhae (kind is identified) decoct, tincture, the .. immersion reaches uterus in place to exsomatizing and all shows excitation, and dosage increases can be spastic contraction, pregnant person acts on obviously to unpregnancy uterus comparison, and strength of uterine contraction reinforcement in puerperal or tonicity are increased; 2. to the effect of blood circulation, Pollen Typhae decoct and ethanol immersion heavy dose can make cat, dog blood pressure drops, and its hypotensive effect can be blocked by atropine.Pollen Typhae alcohol extraction solution can increase contractility to Bufo siccus isolated heart low concentration, and high concentration suppresses it.Heavy dose of Pollen Tyjphae extract is little on the impact of dog heart-lung apparatus, and family's rabbit ear blood vessel is slightly had dilating effect; 3. to the effect of intestinal tube, Pollen Tyjphae extract can make the isolated rabbit enterokinesia strengthen, but can be blocked by atropine.Wherein go through the isorhamnetin that contains the white mice intestine in vitro is had spasmolysis; 4. Blood clotting, oral infusion or 5% ethanol immersion can make the rabbit clotting time obviously shorten; Pollen Tyjphae extract shortens the increase of Rabbit Blood Platelets number, prothrombin time; The external of Pollen Typhae powder has anastalsis to the dog arterial hemorrhage; 5. tuberculosis effect can suppress the growth of tulase, and tuberculosis is had some curative effect.
Radix Polygalae (polygala): bitter, hot, tepor.GUIXIN, kidney, lung meridian.Function cures mainly: the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, and detumescence.Be used for the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Clinical practice: 1. insomnia and dreamful sleep, severe palpitation, forgetful; 2. epilepsy mania and irritation; 3. cough with copious phlegm; 4. skin sore, breast swell and pain, sore throat.
Flos Tulipae Gesnerianae (tulip): cure mainly function: removing dampness is warded off dirty.Main taste turbid damp; Chest distress; Vomiting stomachache; The halitosis greasy fur.
Radix Rehmanniae Preparata (Cultivated land): sweet, tepor.Return liver, kidney channel.Effect: the yin nourishing of enriching blood, life essence-filling, marrow-benefitting.Clinical practice: 1. all cards of blood deficiency; 2. all cards of the hepatic and renal YIN deficiency.This quality is moistened into kidney, kind nourishing kidney yin, and life essence-filling, marrow-benefitting is the key medicine of tonifying kidney-yin; 3. on the impact of medulla hematopoietic system, can promote the recovery of anemia animal erythrocyte, hemoglobin, accelerate propagation, the differentiation of pluripotential hemopoietic stem cell (CFU-S), bone marrow hemopoietic progenitor cell of red blood cell line (CFU-E); 4. on the impact of blood coagulation, Radix Rehmanniae Preparata can significantly suppress liver hemorrhagic necrosis kitchen range and simple necrosis.To the hyperlipemia that high lipid food causes, the hepatic vein hemorrhage that fatty liver and rat endotoxin cause all has the thrombotic effect of inhibition; 5. on immune impact: the Radix Rehmanniae Preparata alcohol extract has significant protective effect to mouse gavaging to the macrophage function that suppressed by carrageenin; Antagonist forms cell inhibitory action; 6. on the impact of cardiovascular system, wine Radix Rehmanniae Preparata and cook Radix Rehmanniae significant hypotensive effect is arranged, systolic pressure and diastolic pressure all significantly descend; 7. antioxidation.
Herba humuli scandentis (Find grass): sweet, bitter, cold.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Be used for the pulmonary tuberculosis hectic fever, gastroenteritis, dysentery, cold, fever, dysuria, pyelonephritis, acute nephritis, cystitis, urinary system calculus; Carbuncle furuncle and phyma poison, eczema, venom are controlled in external.Pharmacological action: 1. antibacterial action; 2. other effect, the guilt oxadiazon has the effect of dinitrophenol sample to cat, and after intravenous injection 3mg/kg, can make oxygen consumption increase immediately 1 times, and rapid breathing occur, fervescence thereupon, can excessively raise because of body temperature (45 ℃) are lethal.A large amount of injections also can produce glycosuria, hematuria.
Described medicine is made by decocting.
Usage: above-mentioned raw materials liquid medicine was fried in shallow oil 20-30 minute, and wherein the crude drug gross weight is 150-200g.Approximately 200 milliliters of extracting juice, 2 times/days, sooner or later respectively once.1 year is a course for the treatment of.
Cure mainly: insomnia of the old people, cranial nerve atrophy, hypomnesis.
Beneficial effect of the present invention is: use treatment by Chinese herbs elderly brain of the present invention atrophy in clinical position, both can be for the cause of disease, dialectical differential diagnosis of diseases, treating both the principal and the secondary aspects of a disease at the same time, the adjusting vital organs of the human body, again can nourishing brain cell, promote brain development, than western medicine effect significantly and have no side effect.
The specific embodiment
The following examples can make those skilled in the art more fully understand the present invention, but do not limit the present invention in any way.
A kind of medicine for the treatment of brain atrophy, it is made by decocting by following raw material medicaments: Placenta Hominis 10 grams, Arillus Longan 10 grams, Fructus Mori 10 grams, the red Radix Paeoniae Alba 10 grams, Radix Pseudostellariae 10 grams, Poria 10 grams, Rhizoma Acori Graminei 10 grams, Radix Salviae Miltiorrhizae 10 grams, Radix Angelicae Sinensis 15 grams, Pollen Tyjphae 15 grams, Radix Polygalae 12 grams, Flos Tulipae Gesnerianae 12 grams, Radix Rehmanniae Preparata 20 grams and Herba humuli scandentis 6 grams.
Test of pesticide effectiveness summary:
Administrated method
The crude drug decocting of the present embodiment 20-30 minute, approximately 200 milliliters of extracting juice, 2 times/days, each is once sooner or later.1 year is a course for the treatment of.
1592 routine cases all come from the department of Chinese medicine out-patient in November, 1~2012 in 2011 of Affiliated Hospital of Yanan University.Be divided into treatment group and each 796 examples of randomized controlled treatment group by the table of random number method.Treatment group: 65~80 years old age, average (72.5 ± 7.2) year; Disease time 6~12 months, average (7.9 ± 2.6) individual month; Matched group: 65~83 years old age, average (74.1 ± 5.3) year; Disease time 7~15 months, average (8.4 ± 4.0) individual month;
Curative effect judgement: 1: IQ judgement: by general IQ method of testing, only note is negative minute, wherein answers irrelevant to the subject person and doubles in negative minute.In 1592 routine cases negative minute of survey was 21 minutes, near normal clinical cure in 2.1 years 861 courses for the treatment of; 329 courses for the treatment of are in 1.7 years, and negative minute of survey is 65 to be divided into improvement; 235 example courses for the treatment of are in 1.1 years, and negative minute of survey is 81 to be divided into effectively; The 167 routine courses for the treatment of, negative minute of survey was for invalid more than 100 minutes in 1.4 years;
The criterion of curative effect
1, cure: (do not comprise negative 20 minutes) below 20 minutes in negative minute;
2, produce effects: (comprise negative 20 minutes, do not comprise negative 80 minutes) between negative minute 20-80;
3, effective: as (to comprise negative 80 minutes, and do not comprise negative 100 minutes) between 80-100 divides in negative minute;
4, invalid: negative minute is 100 minutes and above for invalid.
Efficacy result is analyzed
1,861 example courses for the treatment of, negative minute of survey was 21 minutes, near normal clinical cure in 2.1 years;
2,329 example courses for the treatment of are in 1.7 years, and negative minute of survey is 65 to be divided into improvement;
3,235 example courses for the treatment of are in 1.1 years, and negative minute of survey is 81 to be divided into effectively;
4, the 167 routine courses for the treatment of, negative minute of survey was for invalid more than 100 minutes in 1.4 years;
Using this medicine 1 year was a course for the treatment of, and check once every half a year.At least will continue 3 of regular treatments more than the course for the treatment of, cure rate is up to more than 86%.
The above; only for the better specific embodiment of the present invention, but protection scope of the present invention is not limited to this, anyly is familiar with those skilled in the art in the technical scope that the present invention discloses; the variation that can expect easily or replacement are within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claim.

Claims (2)

1. medicine for the treatment of brain atrophy, it is characterized in that: it is made by the crude drug of following weight parts: 6 parts of 10 parts of Placenta Hominiss, 10 parts of Arillus Longans, 10 parts of Fructus Mori, 10 parts of the red Radix Paeoniae Albas, 10 parts of Radix Pseudostellariaes, 10 parts, Poria, 10 parts of Rhizoma Acori Graminei, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Pollen Tyjphae, 12 parts of Radix Polygalaes, 12 parts of Flos Tulipae Gesnerianaes, 20 parts, Radix Rehmanniae Preparata and Herba humuli scandentis.
2. the medicine for the treatment of brain atrophy according to claim 1, it is characterized in that: described medicine is made by decocting.
CN2013100313073A 2013-01-17 2013-01-17 Medicine for treating encephalatrophy Pending CN103110783A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104587192A (en) * 2015-02-06 2015-05-06 丁桂芹 Traditional Chinese medicine preparation for treating brain atrophy and preparation method thereof
CN105362922A (en) * 2014-08-26 2016-03-02 李敏 Medicine for treating cerebral concussion sequelae

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105362922A (en) * 2014-08-26 2016-03-02 李敏 Medicine for treating cerebral concussion sequelae
CN104587192A (en) * 2015-02-06 2015-05-06 丁桂芹 Traditional Chinese medicine preparation for treating brain atrophy and preparation method thereof

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Application publication date: 20130522