CN101732694B - Medicament for treating chronic diarrhea - Google Patents
Medicament for treating chronic diarrhea Download PDFInfo
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- CN101732694B CN101732694B CN2010101342614A CN201010134261A CN101732694B CN 101732694 B CN101732694 B CN 101732694B CN 2010101342614 A CN2010101342614 A CN 2010101342614A CN 201010134261 A CN201010134261 A CN 201010134261A CN 101732694 B CN101732694 B CN 101732694B
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Abstract
The invention discloses a medicament for treating chronic diarrhea, which is characterized in that: the medicament comprises the following raw material medicaments in part by weight: 6 to 10 parts of bupleurum, 10 to 12 parts of white paeony root, 10 to 12 parts of stir-fried bitter orange, 10 to 15 parts of pilose asiabell root, 10 to 12 parts of Indian buead, 12 to 15 parts of stir-fried largehead atractylodes rhizome, 5 to 10 parts of blast-fried dried ginger, 2 to 5 parts of golden thread, 10 to 12 parts of costustoot, 10 to 15 parts of stir-fried medicated leaven, 5 to 6 parts of roastedchebule, 12 to 15 parts of stir-fried pachyrhizua angulatus and 4 to 6 parts of liquoric root. The medicament is prepared into capsules for administration, can effectively treat chronic diarrhea diseases and has the efficiency of 90.2 percent.
Description
Technical field
The present invention relates to the field of Chinese medicines, what be specifically related to is a kind of medicine for the treatment of chronic diarrhea.
Background technology
Having loose bowels is a kind of common sympton in the digestive system disease, means defecation frequency more than at ordinary times, and feces is shapeless, is half congealed soft, half congealed thin or water sample, or have mucus pus; Often with symptoms such as stomachache, defecation urgency sense, crissum discomfort, incontinences, diarrhoea continues or is frequent, and the period of greater than two months person is called chronic diarrhea repeatedly.All card modern medicines are found in multiple disease, and are existing organic as Anaphylaxis enteritis, non-specific enteritis, ulcerative colitis, chronic enteritis etc., also have functional.Primary disease pathogeny complexity, coverage is wider, does not still have a kind of theory that can explain its etiology and pathogenesis fully, and therapeutic effect is also undesirable.Primary disease belongs to the category that Chinese medicine " is had loose bowels ", and diseased region relates to spleen, stomach, large intestine, and pathogenic key is domination of damp pathogen and dysfunction of spleen and stomach, and causes clear QI being mixed up with turbid QI, and water paddy mixes, and walks large intestine and form.Primary disease is a kind of commonly encountered diseases, frequently-occurring disease clinically, and particularly modern society people operating pressure is very big, and rhythm of life is constantly accelerated, make the chronic diarrhea incidence rate that the trend of obvious rising be arranged, various Nervous and Mental Factors, especially long-term high-pressure makes people suffer from chronic diarrhea protracted course of disease again.Bring great misery to the patient, Most patients is sought medical advice everywhere, diagnosis and treatment in many ways, all poor effect.By clinical practice for many years, the inventor thinks that disharmony between the liver and spleen plays crucial effects in the whole process of chronic diarrhea disease.Modern medicine also shows that digestive system is the important target organ of psychosoma relative theory, emotion changes, diet stimulation etc. is had the sensitivity of height.Disharmony between the liver and spleen clinical common two big classes, the one: insufficiency of the spleen stagnation of liver-QI, stagnation of liver-QI are the catharsis dysfunctions of liver, i.e. catharsis is too late, and disease is as having loose bowels repeatedly, or aqueous-grainy diarrhea, with gastral cavity abdomen feeling of fullness, and belching and acid regurgitation, pale tongue with thin fur, thready pulse slightly stringy pulse, this meaning " the liver failing to dredge the spleen "; The 2nd: insufficiency of the spleen liver is strong, and liver is by force that the catharsis function of liver is excited, i.e. catharsis too, disease is let out as stomachache, lets out the back alleviation of pain, pain is let out multiple work, and is painful with gastral cavity abdominal distention, attacks companys of the scurrying side of body, thready and stringy pulse, thin lingual fur or white greasy, this meaning " wooden prosperous gram is native ".
Summary of the invention
In view of the deficiency that background technology exists, the technical problem that medicine of the present invention solves is to pay attention to regulating the liver and spleen, regulates people's feelings will factor, can effectively treat the medicine of chronic diarrhea.
For this reason, medicine of the present invention is to select Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii (parched), Radix Codonopsis, Poria, Rhizoma Atractylodis Macrocephalae (parched), gun ginger, Rhizoma Coptidis, the Radix Aucklandiae, Massa Medicata Fermentata preparata, stewing Fructus Chebulae, Radix Glycyrrhizae to be equipped with to form.Selecting Radix Bupleuri, is because Radix Bupleuri bitter in the mouth suffering is slightly cold, and returns the liver and gall warp, has dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, the merit of regulating functional activities of qi; Selecting the Radix Paeoniae Alba, is that the liver spleen channel is returned in bitter in the mouth acid, has the yin fluid astringing of nourishing blood because of Radix Paeoniae Alba cold nature, and easing the affected liver to relieve pain can be used for disharmony in liver-QI, side of body rib epigastric pain, abdominal pain diarrhea; Selecting Fructus Aurantii (parched), is because Fructus Aurantii (parched) nature and flavor toil temperature is returned the taste large intestine channel, regulating the flow of QI to ease the stomach, and the stagnant relieving distension of row is used for, distension and fullness of the chest and abdomen, accumulation of food in the stomach and intes tine due to indigestion; Select Radix Codonopsis to be because Radix Codonopsis is flat, sweet in the mouth, the spleen lung meridian is returned in little acid, invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting is used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool; Select Poria to be because Poria is flat, slightly sweet flavor, GUIXIN lung spleen kidney channel, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming is used for insufficiency of the spleen lack of appetite, has loose bowels; Selecting Rhizoma Atractylodis Macrocephalae (parched) is that bitter but sweet flavor is returned the taste warp because Rhizoma Atractylodis Macrocephalae (parched) is warm in nature, invigorating the spleen and benefiting QI, and the dampness diuretic is used for insufficiency of the spleen lack of appetite, and abdominal distention is had loose bowels, the phlegm retention vertigo and palpitation; Selecting gun ginger, is that acrid in the mouth is returned taste cardiopulmonary warp because gun ginger is hot in nature, and warming spleen and stomach for dispelling cold is used for Deficiency and coldness of spleen and stomach, coldness and pain in the epigastrium, vomiting due to pathogenic cold, cold diarrhea; Select Rhizoma Coptidis to be because Rhizoma Coptidis is cold in nature, bitter in the mouth, GUIXIN taste liver and gall large intestine channel, heat clearing and damp drying, eliminating fire and detoxication is with controlling diarrhoea, dysentery, vomiting etc.; Selecting the Radix Aucklandiae, is that the acrid in the mouth hardship is returned taste large intestine, three warmers gallbladder meridian because the Radix Aucklandiae is warm in nature, the spleen invigorating promoting the circulation of QI to relieve pain, and with controlling breast gastral cavity distending pain, heavy behind the dysentery, food stagnation does not disappear, the stomachache of having loose bowels; Selecting Massa Medicata Fermentata preparata, is that the stomach function regulating that helps digestion is with controlling accumulation of food in the stomach and intes tine due to indigestion, distension and fullness in the abdomen, anorexia, borborygmus diarrhoea etc. because its sweet in the mouth suffering warm in nature is gone into taste two warps; Selecting to simmer son, is because the flat sour-puckery flavor of its property whets the appetite in the controlled atmosphere under the expectorant, helps digestion, be used for hemorrhoidal hamorrhage and rush down blood; Selecting Radix Glycyrrhizae, is that sweet in the mouth is returned 12 warps because Radix Glycyrrhizae property is flat, and detoxifcation is eliminated the phlegm, and pain relieving is used for the anxious pain of stomachache, stomachache and gastrocnemius contraction.
Seeing above-mentioned prescription, is that the side of closing of getting " Sini San " and " decoction of four noble drugs " adds gun ginger, Rhizoma Coptidis, the Radix Aucklandiae, Massa Medicata Fermentata preparata, the stewing Fructus Chebulae forms, and is the prescription of reconciliation and tonification and usefulness in fact." Sini San " is soothing the liver reason spleen, the effect of harmonizing the functional activities of vital QI cures mainly the card of incoordination between the liver and spleen; " decoction of four noble drugs " merit is apt to replenishing QI to invigorate the spleen, the main syndrome of deficiency of spleen qi and stomach qi for the treatment of; Add the hot row of Radix Aucklandiae hardship and let out, can the circulation of qi promoting spleen invigorating, can unclog and readjust liver and gall again and join " Sini San " and strengthen the merit that it unclogs and readjusts the liver spleen, join " decoction of four noble drugs " and make it tonify without causing stagnation; The suffering temperature of gun ginger is with warming middle-JIAO to stop diarrhea, and Rhizoma Coptidis is bitter can be drying damp and strengthening spleen, can make again Rhizoma Zingiberis Preparatum intimately also.Bitter cold is with the painful abdominal mass that disappears that expels the heat-evil, and it is sour and astringent to simmer Fructus Chebulae, the energy relieving diarrhea with astringents; Massa Medicata Fermentata preparata promoting digestion and invigorating the stomach and middle antidiarrheal.Full side's depressed liver-energy dispersing and QI regulating, warming middle-JIAO and strengthening the spleen, relieving diarrhea with astringents, the gentle soothing the liver and sweet benefit spleen invigorating of acid is gone forward side by side, spleen reinforcing soil and eliminating pathogen in the liver wood, the liver spleen is ruled together.
In order to reach better therapeutic, as if deficient earth being subjugated by wood, stomachache obviously, can add Rhizoma Corydalis in the above-mentioned prescription, this is that the acrid in the mouth hardship has promoting blood circulation to remove blood stasis because Rhizoma Corydalis is warm in nature, the merit of gentle pain relieving is used for pain of each qi depression to blood stasis of whole body.
If see weakness of spleen-YANG, yin-cold excess; Incessant chronic diarrhea, number of times are frequently many, can suitably add the product Pericarpium Granati and the Fructus Psoraleae of restrain antidiarrheal, and this is warm in nature because of Pericarpium Granati, and sour-puckery flavor is returned the large intestine kidney channel, and astringing intestine to stop diarrhea stops blooding, and is used for bacillary dysentery; Fructus Psoraleae is warm in nature, and the acrid in the mouth hardship is returned kidney heart taste lung meridian, and reinforcing the kidney and supporting YANG is warming spleen and stopping diarrha.
The consumption of drug component of the present invention also is to draw under a large amount of explorations, and the consumption of each crude drug has better curative effect in subordinate's weight range.Radix Bupleuri 6
-10 parts
,Radix Paeoniae Alba 10-12 part, Fructus Aurantii (parched) 10-12 part, Radix Codonopsis 10-15 part, Poria 10-12 part, Rhizoma Atractylodis Macrocephalae (parched) 12-15 part, gun ginger 5-10 part, Rhizoma Coptidis 2-5 part, Radix Aucklandiae 10-12 part, Massa Medicata Fermentata preparata 10-15 part is simmered Fructus Chebulae 5-6 part, Radix Glycyrrhizae 4-6 part.
Another kind of prescription of the present invention is: Radix Bupleuri 6
-10 parts
,Radix Paeoniae Alba 10-12 part, Fructus Aurantii (parched) 10-12 part, Radix Codonopsis 10-15 part, Poria 10-12 part, Rhizoma Atractylodis Macrocephalae (parched) 12-15 part, gun ginger 5-10 part, Rhizoma Coptidis 2-5 part, Radix Aucklandiae 10-12 part, Massa Medicata Fermentata preparata 10-15 part is simmered Fructus Chebulae 5-6 part, Radix Glycyrrhizae 4-6 part, Rhizoma Corydalis 10-15 part.
Another prescription of the present invention is: Radix Bupleuri 6
-10 parts
,Radix Paeoniae Alba 10-12 part, Fructus Aurantii (parched) 10-12 part, Radix Codonopsis 10-15 part, Poria 10-12 part, Rhizoma Atractylodis Macrocephalae (parched) 12-15 part, gun ginger 5-10 part, Rhizoma Coptidis 2-5 part, Radix Aucklandiae 10-12 part, Massa Medicata Fermentata preparata 10-15 part, simmer Fructus Chebulae 5-6 part, Radix Glycyrrhizae 4-6 part, Pericarpium Granati 10-12 part, Fructus Psoraleae 10-12 part.
Each above-mentioned prescription is that to rule together with soothing liver and strengthening spleen, liver spleen be principle.These drug regimens make each efficacy of drugs produce synergism, thereby can more effectively treat chronic diarrhea.
The specific embodiment
Describe preparation method and the beneficial effect of the present invention that medicine of the present invention is made capsule preparations in following in detail.
The preparation method of first prescription in the foregoing invention content is at first described:
(1) takes by weighing 120 kilograms of Radix Bupleuri
,240 kilograms of the Radix Paeoniae Albas, 200 kilograms of Fructus Aurantii (parched), 300 kilograms of Radix Codonopsis, 200 kilograms in Poria, 240 kilograms of Rhizoma Atractylodis Macrocephalae (parched)s, the gun ginger double centner, 60 kilograms of Rhizoma Coptidis, 200 kilograms of the Radix Aucklandiae, 300 kilograms of Massa Medicata Fermentata preparatas are simmered the Fructus Chebulae double centner, the Radix Glycyrrhizae double centner.Smash standby;
(2) will add 80% ethanol of 3 times of amounts of raw material gross weight in step (1) weighting raw materials, reflux, extract, was filtered more than 1 hour, reclaimed ethanol, obtained concentrated solution and medicinal residues and retained standby respectively;
(3) medicinal residues add 8 times of water gagings, decoct, and about 1 hour of decocting time, it is standby that separation obtains decoction liquor, and medicinal residues are abandoned;
(4) concentrated solution liquid and decoction liquor merge, and being concentrated into relative density is 1.15～1.25(25 ℃) extractum, add 3% beta-schardinger dextrin-adjuvant, mixing, it is standby to make fluid extract;
(5) fluid extract is carried out spray drying, and pulverized 80 mesh sieves, make the drug extract powder, standby;
(6) with the medicinal substances extract powder, add calcium carbonate 30g～50g, starch 10g～30g adopts wet-mixed to granulate, and behind the particle drying, with No. 1 capsule, makes capsule, the about 0.3g of every capsules content weight.
Preparation method for second prescription in the summary of the invention:
(1) takes by weighing 120 kilograms of Radix Bupleuri
,240 kilograms of the Radix Paeoniae Albas, 200 kilograms of Fructus Aurantii (parched), 300 kilograms of Radix Codonopsis, 200 kilograms in Poria, 240 kilograms of Rhizoma Atractylodis Macrocephalae (parched)s, the gun ginger double centner, 60 kilograms of Rhizoma Coptidis, 200 kilograms of the Radix Aucklandiae, 300 kilograms of Massa Medicata Fermentata preparatas are simmered the Fructus Chebulae double centner, Radix Glycyrrhizae double centner, 200 kilograms of Rhizoma Corydalis.Smash standby;
(2) will add 80% ethanol of 3 times of amounts of raw material gross weight in step (1) weighting raw materials, reflux, extract, was filtered more than 1 hour, reclaimed ethanol, obtained concentrated solution and medicinal residues and retained standby respectively;
(3) medicinal residues add 8 times of water gagings, decoct, and about 1 hour of decocting time, it is standby that separation obtains decoction liquor, and medicinal residues are abandoned;
(4) concentrated solution liquid and decoction liquor merge, and being concentrated into relative density is 1.15～1.25(25 ℃) extractum, add 3% beta-schardinger dextrin-adjuvant, mixing, it is standby to make fluid extract;
(5) fluid extract is carried out spray drying, and pulverized 80 mesh sieves, make the drug extract powder, standby;
(6) with the medicinal substances extract powder, add calcium carbonate 30g～50g, starch 10g～30g adopts wet-mixed to granulate, and behind the particle drying, with No. 1 capsule, makes capsule, the about 0.3g of every capsules content weight.
Preparation method for the 3rd prescription in the summary of the invention:
(7) take by weighing 120 kilograms of Radix Bupleuri
,240 kilograms of the Radix Paeoniae Albas, 200 kilograms of Fructus Aurantii (parched), 300 kilograms of Radix Codonopsis, 200 kilograms in Poria, 240 kilograms of Rhizoma Atractylodis Macrocephalae (parched)s, gun ginger double centner, 60 kilograms of Rhizoma Coptidis, 200 kilograms of the Radix Aucklandiae, 300 kilograms of Massa Medicata Fermentata preparatas are simmered the Fructus Chebulae double centner, the Radix Glycyrrhizae double centner, 200 kilograms of Rhizoma Corydalis, 240 kilograms of Pericarpium Granatis, 240 kilograms of Fructus Psoraleaes.Smash standby;
(8) will add 80% ethanol of 3 times of amounts of raw material gross weight in step (1) weighting raw materials, reflux, extract, was filtered more than 1 hour, reclaimed ethanol, obtained concentrated solution and medicinal residues and retained standby respectively;
(9) medicinal residues add 8 times of water gagings, decoct, and about 1 hour of decocting time, it is standby that separation obtains decoction liquor, and medicinal residues are abandoned;
(10) concentrated solution liquid and decoction liquor merge, and being concentrated into relative density is 1.15～1.25(25 ℃) extractum, add 3% beta-schardinger dextrin-adjuvant, mixing, it is standby to make fluid extract;
(11) fluid extract is carried out spray drying, and pulverized 80 mesh sieves, make the drug extract powder, standby;
(12) with the medicinal substances extract powder, add calcium carbonate 30g～50g, starch 10g～30g adopts wet-mixed to granulate, and behind the particle drying, with No. 1 capsule, makes capsule, the about 0.3g of every capsules content weight.
Below by the clinical trial example beneficial effect of medicine of the present invention is described, the present invention is above-mentioned, and to make that medicine names be " the intestines and stomach is strong ".
1, physical data
Accept case 62 examples for medical treatment, patient male's 32 examples, female patient 30 examples; Age is between 19-62 years old.Medical history the shortest February, reach most 15 years surplus; Wherein: proctosigmoiditis 15 examples, Anaphylaxis enteritis 6 examples, ulcerative colitis 2 examples, intestinal bowel syndrome 10 examples.
2, Therapeutic Method
Take the capsule that above-mentioned first prescription makes, every day three times, once two, use warm water delivery service, two weeks were a course of treatment.
3, efficacy assessment standard
Cure: stool is normal, other transference cures, and Clinical Laboratory is normal.
Take a turn for the better: times of defecation obviously reduces, other doing well,improvings.
Invalid: symptom is not seen improvement.
4, therapeutic outcome
Cure 46 examples, account for 74 .1%; 10 examples that take a turn for the better account for 16.1%, and invalid 6 examples account for 9.6 %; Symptom is clearly better after follow up a case by regular visits to, patient's major part was taken medicine 3 days, all alleviates relatively in the week; Because of self irregular eating, uncontrolled or fail to follow the doctor's advice and take medicine, symptom does not have and is clearly better among the 6 routine invalid patients.
By analysis as seen, take medicine of the present invention and treat slower diarrhea, its effective percentage reaches 90.2%.
Claims (3)
1. medicine for the treatment of chronic diarrhea is characterized in that it is made by the crude drug of following weight ratio: Radix Bupleuri 6
-10 parts
,Radix Paeoniae Alba 10-12 part, Fructus Aurantii (parched) 10-12 part, Radix Codonopsis 10-15 part, Poria 10-12 part, Rhizoma Atractylodis Macrocephalae (parched) 12-15 part, gun ginger 5-10 part, Rhizoma Coptidis 2-5 part, Radix Aucklandiae 10-12 part, Massa Medicata Fermentata preparata 10-15 part is simmered Fructus Chebulae 5-6 part, Radix Glycyrrhizae 4-6 part.
2. medicine for the treatment of chronic diarrhea is characterized in that it is made by the crude drug of following weight ratio: Radix Bupleuri 6-10 part, Radix Paeoniae Alba 10-12 part, Fructus Aurantii (parched) 10-12 part, Radix Codonopsis 10-15 part, Poria 10-12 part, Rhizoma Atractylodis Macrocephalae (parched) 12-15 part, gun ginger 5-10 part, Rhizoma Coptidis 2-5 part, Radix Aucklandiae 10-12 part, Massa Medicata Fermentata preparata 10-15 part, simmer Fructus Chebulae 5-6 part, Radix Glycyrrhizae 4-6 part, Rhizoma Corydalis 10-15 part.
3. medicine for the treatment of chronic diarrhea is characterized in that it is made by the crude drug of following weight ratio: Radix Bupleuri 6-10 part, Radix Paeoniae Alba 10-12 part, Fructus Aurantii (parched) 10-12 part, Radix Codonopsis 10-15 part, Poria 10-12 part, Rhizoma Atractylodis Macrocephalae (parched) 12-15 part, gun ginger 5-10 part, Rhizoma Coptidis 2-5 part, Radix Aucklandiae 10-12 part, Massa Medicata Fermentata preparata 10-15 part is simmered Fructus Chebulae 5-6 part, Radix Glycyrrhizae 4-6 part, Pericarpium Granati 10-12 part, Fructus Psoraleae 10-12 part.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101342614A CN101732694B (en) | 2010-03-29 | 2010-03-29 | Medicament for treating chronic diarrhea |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101342614A CN101732694B (en) | 2010-03-29 | 2010-03-29 | Medicament for treating chronic diarrhea |
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| CN101732694A CN101732694A (en) | 2010-06-16 |
| CN101732694B true CN101732694B (en) | 2011-06-29 |
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|---|---|---|---|
| CN2010101342614A Expired - Fee Related CN101732694B (en) | 2010-03-29 | 2010-03-29 | Medicament for treating chronic diarrhea |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102772746A (en) * | 2012-08-21 | 2012-11-14 | 黄平县润发药业农民专业合作社 | Chinese medicinal prescription for treating diarrhea |
| CN106421084A (en) * | 2016-11-07 | 2017-02-22 | 成都泠汐尚品科技有限公司 | Traditional Chinese medicinal composition for treating chronic diarrhea |
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2010
- 2010-03-29 CN CN2010101342614A patent/CN101732694B/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 张振雷，等.慢性泄泻辨治心得.《中医药临床杂志》.2007,第19卷(第5期),516-517. * |
| 罗珊珊,等.李幼昌诊治儿科消化系疾病的经验.《辽宁中医杂志》.2008,第35卷(第4期),502-503. * |
| 韩明鹤.情志不遂致肠易激综合征的辨治探讨.《长春中医药大学学报》.2007,第23卷(第1期),31-32. * |
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