CN102526673B - Chinese medicine capsule, Chinese medicine liquid and health-care oral liquid for treating dilated cardiomyopathy and manufacture method - Google Patents
Chinese medicine capsule, Chinese medicine liquid and health-care oral liquid for treating dilated cardiomyopathy and manufacture method Download PDFInfo
- Publication number
- CN102526673B CN102526673B CN 201210024617 CN201210024617A CN102526673B CN 102526673 B CN102526673 B CN 102526673B CN 201210024617 CN201210024617 CN 201210024617 CN 201210024617 A CN201210024617 A CN 201210024617A CN 102526673 B CN102526673 B CN 102526673B
- Authority
- CN
- China
- Prior art keywords
- radix
- weight portions
- hours
- mastic
- filtrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a Chinese medicine capsule, Chinese medicine liquid and health-care oral liquid for treating dilated cardiomyopathy and a manufacture method, wherein the Chinese medicine capsule comprises codonopsis pilosula, astragalus membranaceus, Chinese-date, radix rubiae, red flower, herba lycopi, leech, radix ophiopogonis, cassia twig, pseudo-ginseng, coix seed, radix stephaniae tetrandrae, radix paeoniae rubra, dried ginger and pepperweed seed. The Chinese medicine capsule has the advantages of being good in curative effect, low in cost, high in curative rate, small in limitation, free of adverse drug effect and the like in terms of treating the dilated cardiomyopathy.
Description
Technical field
The present invention relates to a kind of medicinal preparation, relate in particular to a kind of Chinese medicine preparation that is used for the treatment of dilated cardiomyopathy.
Background technology
Dilated cardiomyopathy (dilated cardiomyopathy, DCM) belong to the not bright primary cardiac myopathy based on cardiomyopathy of reason, it is with a left side or right ventricle or the expansion of bilateral ventricle, and be feature with myocardial hypertrophy, ventricular systolic function goes down, companion or do not accompany congestive heart failure, chamber property or atrial arrhythmia are seen more.Chinese and overseas scholars's majority thinks that the generation development of dilated cardiomyopathy damages relevant with the viral infection of persistence and the myocardium autoimmune that causes thus.
Cardiomyopathy is the main diseases therefore that causes heart failure except coronary heart disease and hypertension, its clinical manifestation is to carry out DHF, arrhythmia, thromboembolism, even sudden death is for basic feature, yet the cause of disease of dilated cardiomyopathy is very complicated, and diagnosis is difficulty.Though doctor trained in Western medicine has obtained significant progress for the treatment of heart failure (heart failure), but because limitation and the untoward reaction thereof of medicine, and the complexity of dilated cardiomyopathy itself, primary disease only is 40% in the survival rate that back 5a appears in symptom, the survival rate of 10a is only about 22%, and the doctor trained in Western medicine spininess is to symptomatic treatments such as heart failures, and is aided with statins, because statins can effectively reduce especially LDL of plasma cholesterol, can significantly reduce evidence of coronary heart diseases and case fatality rate.These curative effects that statins produces may can stabilize plaque and to improve vascular endothelial function relevant with it.Yet, use this class medicine during chronic heart failure, may have potential ill effect, pass through to solidify and remove the protective effect that endotoxin toxicity is brought into play as what lipoprotein provided, may the forfeiture etc. because of the blood fat reducing effect of statins.
Chinese medicine thinks, dilated cardiomyopathy take good care of oneself improper with natural endowment, idiosyncrasy, the day after tomorrow and factor such as the warm malicious heresy of repeated infection relevant.Warm poison is evil goes into nutrient blood from the mouth and nose invasion by defending gas, volt in poison is evil, and nutrient blood is become estranged, and poison stays passages through which vital energy circulates, removes for a long time and not, and interior the house in the heart causes obstructed the forming of heart network numbness resistance.The evil whole pathological process that takes place, develops and change through dilated cardiomyopathy of poison is finally because poison causes the stasis of blood, because poison is just being hindered.Poison, the stasis of blood, void are main etiology and pathogenesis, and the three mutually promotes, and form vicious cycle, the evil dark volt of poison, and patient's condition is touching, and seriously ill difficulty is more.
At present, Chinese medicine is still common with single pattern of syndrome or a card one side's treatment to the research of dilated cardiomyopathy, and the differentiation of symptoms and signs for classification of syndrome opinion is controlled these Chinese traditional treatment characteristics and seldom used; Clinical diagnosis standard, efficacy assessment standard disunity lack multicenter, study on large sample and long-term, follow-up observation; The relapse rate of Chinese medicine dilated cardiomyopathy, the adverse reaction rate of long-term prescription are observed seldom, and the late result of Chinese medicine is still indeterminate.
Summary of the invention
Technical problem to be solved by this invention is, overcome the deficiency of existing western medicine dilated cardiomyopathy, utilize the traditional theory of Chinese medical science of China, the Chinese medicine preparation of the treatment dilated cardiomyopathy that provide a kind of good effect, cost is low, cure rate is high, limitation is little, has no adverse reaction.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicinal capsule that is used for the treatment of dilated cardiomyopathy, it comprises: Radix Codonopsis, the Radix Astragali, Fructus Jujubae, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo, Radix Ophiopogonis, Ramulus Cinnamomi, Radix Notoginseng, Semen Coicis, Radix Stephaniae Tetrandrae, Radix Paeoniae Rubra, Rhizoma Zingiberis and Semen Lepidii (Semen Descurainiae).
Wherein, the ratio of weight and number of various components is, Radix Codonopsis 34～37 weight portions, the Radix Astragali 42～46 weight portions, Fructus Jujubae 23～25 weight portions, Radix Rubiae 19～23 weight portions, Flos Carthami 25～27 weight portions, Herba Lycopi's 14～18 weight portions, Hirudo 20～22 weight portions, Radix Ophiopogonis 29～32 weight portion, Ramulus Cinnamomi 12～15 weight portions, Radix Notoginseng 24～26 weight portions, Semen Coicis 14～16 weight portions, Radix Stephaniae Tetrandrae 21～23 weight portions, Radix Paeoniae Rubra 10～12 weight portions, Rhizoma Zingiberis 13～15 weight portions and Semen Lepidii (Semen Descurainiae) 15～17 weight portions.
For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicinal capsule, and it comprises:
The first step, Radix Codonopsis, the Radix Astragali, Fructus Jujubae and Radix Ophiopogonis are mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, adopt percolation (" Chinese pharmacopoeia version appendix in 2010 I O) with the speed of per minute 1～2ml percolation slowly, collect percolate, being concentrated into relative density is the mastic of 1.29～1.32 (70 ℃), and wherein, the amount of the ethanol of adding is 2～4 times of first step mixture quality;
Second goes on foot, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo and Radix Notoginseng is mixed in proportion, decoct with water twice, the each decoction 1 hour～2 hours, filter respectively, merging filtrate, filtrate is condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of second mixture quality that goes on foot;
The 3rd goes on foot, remaining component is mixed in proportion, and decocts with water twice, decocts 1 hour～2 hours at every turn, filter respectively, merging filtrate, filtrate are condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of the 3rd mixture quality that goes on foot;
The 4th goes on foot, above-mentioned mastic and starch is mixed, the ratio of the quality sum of the quality of described starch and the mastic that obtains is 0.1:1～0.3:1, carry out pelletization treatment, dried subsequently, obtain compound particles, further in compound particles, add magnesium stearate again, the ratio of described magnesium stearate and described compound particles quality is 0.15～100:0.5～100, obtains capsule 's content, described capsule 's content is incapsulated namely get capsule in the housing.
For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine oral liquid that is used for the treatment of dilated cardiomyopathy, and it comprises: Radix Codonopsis, the Radix Astragali, Fructus Jujubae, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo, Radix Ophiopogonis, Ramulus Cinnamomi, Radix Notoginseng, Semen Coicis, Radix Stephaniae Tetrandrae, Radix Paeoniae Rubra, Rhizoma Zingiberis and Semen Lepidii (Semen Descurainiae).
Wherein, the ratio of weight and number of various components is, Radix Codonopsis 34～37 weight portions, the Radix Astragali 42～46 weight portions, Fructus Jujubae 23～25 weight portions, Radix Rubiae 19～23 weight portions, Flos Carthami 25～27 weight portions, Herba Lycopi's 14～18 weight portions, Hirudo 20～22 weight portions, Radix Ophiopogonis 29～32 weight portion, Ramulus Cinnamomi 12～15 weight portions, Radix Notoginseng 24～26 weight portions, Semen Coicis 14～16 weight portions, Radix Stephaniae Tetrandrae 21～23 weight portions, Radix Paeoniae Rubra 10～12 weight portions, Rhizoma Zingiberis 13～15 weight portions and Semen Lepidii (Semen Descurainiae) 15～17 weight portions.
For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine oral liquid, it is characterized in that, comprising:
The first step, Radix Codonopsis, the Radix Astragali, Fructus Jujubae and Radix Ophiopogonis are mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, adopt percolation (" Chinese pharmacopoeia version appendix in 2010 I O) with the speed of per minute 1～2ml percolation slowly, collect percolate, being concentrated into relative density is the mastic of 1.29～1.32 (70 ℃), and wherein, the amount of the ethanol of adding is 2～4 times of first step mixture quality;
Second goes on foot, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo and Radix Notoginseng is mixed in proportion, decoct with water twice, the each decoction 1 hour～2 hours, filter respectively, merging filtrate, filtrate is condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of second mixture quality that goes on foot;
The 3rd goes on foot, remaining component is mixed in proportion, and decocts with water twice, decocts 1 hour～2 hours at every turn, filter respectively, merging filtrate, filtrate are condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of the 3rd mixture quality that goes on foot;
The 4th step, described mastic is mixed, add water, the quality of the water that adds is 1～1.5 times of described mastic mixture quality, mixing, cold preservation 24 hours～48 hours, filter, add cane sugar powder, active carbon in the filtrate, carry out heat treated, filtration treatment, embedding processing, sterilization treatment successively, obtain oral liquid; The weight ratio of described filtrate and cane sugar powder is 1: 0.1～0.3; The weight ratio of described filtrate and active carbon is 1: 0.001～0.002; The described heat treated time is 20～40 minutes, and temperature is 100 ℃～110 ℃, and the crude drug concentration in the described oral liquid is 0.9g/mL～1.5g/mL.。
For solving the problems of the technologies described above, the present invention also provides a kind of healthcare dietetic liquid, and it comprises following component: Radix Codonopsis, the Radix Astragali, Fructus Jujubae, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo, Radix Ophiopogonis, Ramulus Cinnamomi, Radix Notoginseng, Semen Coicis, Radix Stephaniae Tetrandrae, Radix Paeoniae Rubra, Rhizoma Zingiberis and Semen Lepidii (Semen Descurainiae).
Wherein, the ratio of weight and number of various components is: Radix Codonopsis 34～37 weight portions, the Radix Astragali 42～46 weight portions, Fructus Jujubae 23～25 weight portions, Radix Rubiae 19～23 weight portions, Flos Carthami 25～27 weight portions, Herba Lycopi's 14～18 weight portions, Hirudo 20～22 weight portions, Radix Ophiopogonis 29～32 weight portion, Ramulus Cinnamomi 12～15 weight portions, Radix Notoginseng 24～26 weight portions, Semen Coicis 14～16 weight portions, Radix Stephaniae Tetrandrae 21～23 weight portions, Radix Paeoniae Rubra 10～12 weight portions, Rhizoma Zingiberis 13～15 weight portions and Semen Lepidii (Semen Descurainiae) 15～17 weight portions.
For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned healthcare dietetic liquid, and it comprises:
The first step, Radix Codonopsis, the Radix Astragali, Fructus Jujubae and Radix Ophiopogonis are mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, adopt percolation (" Chinese pharmacopoeia version appendix in 2010 I O) with the speed of per minute 1～2ml percolation slowly, collect percolate, being concentrated into relative density is the mastic of 1.29～1.32 (70 ℃), wherein, the amount of the ethanol of adding is 2～4 times of first step mixture quality;
Second goes on foot, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo and Radix Notoginseng is mixed in proportion, decoct with water twice, the each decoction 1 hour～2 hours, filter respectively, merging filtrate, filtrate is condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of second mixture quality that goes on foot;
The 3rd goes on foot, remaining component is mixed in proportion, and decocts with water twice, decocts 1 hour～2 hours at every turn, filter respectively, merging filtrate, filtrate are condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of the 3rd mixture quality that goes on foot;
The 4th step, described mastic is mixed, add water, the quality of the water that adds is 3～10 times of described mastic mixture qualities, mixing, cold preservation 24 hours～48 hours, filter, add cane sugar powder, active carbon in the filtrate, carry out heat treated, filtration treatment, embedding processing, sterilization treatment successively, obtain oral liquid; The weight ratio of described filtrate and cane sugar powder is 1: 0.1～0.3; The weight ratio of described filtrate and active carbon is 1: 0.001～0.002; The described heat treated time is 20～40 minutes, and temperature is 100 ℃～110 ℃, and the crude drug concentration in the described oral liquid is 0.1g/mL～0.3g/mL.
Beneficial effect of the present invention:
With respect to the medicine that is used for the treatment of dilated cardiomyopathy of the prior art, adopt this Chinese medicine preparation advantages such as treatment has good effect to dilated cardiomyopathy, cost is low, cure rate is high, limitation is little, have no adverse reaction.
The specific embodiment
Dilated cardiomyopathy is the agnogenic cardiomyopathy of principal character with chambers of the heart expansion, myocardium shrinkage function obstacle, clinical manifestation is basic feature to carry out DHF, arrhythmia, thromboembolism or sudden death, belongs to traditional Chinese medical science categories such as " the syndrome of dyspnea, cardiopalmus, the thoracic obstruction ".Its sick position is at the heart, disease can be involved lung for a long time, spleen, kidney, how be this with the deficiency of qi and yin, stagnation of blood stasis, fluid-retention stagnating in the interior is mark, based on this, Chinese medicine preparation of the present invention is with supplementing QI and nourishing YIN, activating blood and promoting diuresis is the Therapeutic Principle, by the combination Radix Codonopsis, the Radix Astragali, Fructus Jujubae, Radix Rubiae, Flos Carthami, the Herba Lycopi, Hirudo, Radix Ophiopogonis, Ramulus Cinnamomi, Radix Notoginseng, Semen Coicis, Radix Stephaniae Tetrandrae, Radix Paeoniae Rubra, Rhizoma Zingiberis and Semen Lepidii (Semen Descurainiae), to reach this Therapeutic Principle, Radix Codonopsis in the side, the Radix Astragali, the Fructus Jujubae strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid, Radix Codonopsis and the Radix Astragali can also be removed interior free yl, superoxide dismutase activity is strengthened, lipid peroxide content reduces, and has antiviral, expand blood vessel, diuresis, immunoregulation effect, Fructus Jujubae also have coronary artery dilator, increase the amount of blood supply of brain and heart, the function of decreasing heart rate; Radix Rubiae, Flos Carthami and Herba Lycopi's cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling can increase coronary flow, and the myocardial nutritional flow amount resists myocardial ischemia; Hirudo can pursue stagnant blood, blood stasis, removing blood stasis disease and gather; Radix Notoginseng hemostasis dissipating blood stasis, the protection cardiac muscle; Radix Ophiopogonis, nourishing YIN and moistening the lung, heat clearing away were nourished heart; The Ramulus Cinnamomi warming the meridian and promoting blood circulation, horizontal logical podomere; Semen Coicis spleen invigorating eliminating dampness by diuresis, the immunocompetence of raising body; The Radix Stephaniae Tetrandrae inducing diuresis to remove edema, energy coronary artery dilator, increase coronary flow; The Radix Paeoniae Rubra cool the blood dissipate blood stasis; The Rhizoma Zingiberis warming spleen and stomach for dispelling cold; Semen Lepidii (Semen Descurainiae) eliminating the pathogens from the lung sending down the abnormal ascending QI, eliminating phlegm and relieving asthma, inducing diuresis to remove edema has the effect of heart tonifying, can strengthen myocardial contraction.
Radix Codonopsis: property is flat, and spleen, lung meridian are returned in sweet in the mouth, little acid, play invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting is used for deficiency of the spleen and lung, inappetence, fatigue and weakness, the cardiopalmus of breathing hard, QI and blood deficiency, dyspnea due to deficiency cough, interior-heat card such as quench one's thirst, Radix Codonopsis energy enhancing human body immunity function, strengthen the ability of removing free radical, the cardiovascular system various piece is had certain regulating action, be usually used in treating coronary heart disease.
The Radix Astragali: sweet in the mouth, warm in nature, go into spleen, lung meridian, tonification spleen soil is arranged, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, effects such as holder skin ulcer granulation promoting are mainly used in the weak anorexia and loose stool due to the deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, cards such as insufficiency of vital energy and blood.The Radix Astragali strengthens the heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; Can improve the nonspecific immunity power of body, the effect that protects the liver with blood sugar lowering is arranged, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had inhibitory action.But Radix Astragali appreciable impact splenocyte information conduction, realize immunoregulation effect, cellular metabolism and cardiovascular system there is remarkable effect, heavy dose of application Radix Astragali can promote the normal operation of QI and blood, improve cardiac function, eliminate body circulatory disturbance, modern pharmacology proves, the Radix Astragali can be removed interior free yl, and superoxide dismutase activity is strengthened, and lipid peroxide content reduces, have antiviral, expand blood vessel, diuresis, immunoregulation effect, can obviously strengthen myocardial contraction, cardiac output and cardiac index are obviously increased, be conducive to lightening heart load.
Fructus Jujubae: sweet in the mouth, warm in nature, go into spleen, stomach warp, have the effect of air making-up and spleen enlivening, nourishing blood to tranquillize the mind, harmonizing yingfen and weifen, the mitigation property of medicine, be used for weakness of the spleen and stomach, fatigue and asthenia, anorexia and loose stool, insufficiency of vital energy and blood, have a headache and fever, cards such as sweating hot blast, Fructus Jujubae has the effect of muscle strength reinforcing, has the total serum protein of increasing and albuminous function.Contain abundant vitamin C, Citrin in the Fructus Jujubae, to perfecting blood capillary, keeping vessel wall elasticity, atherosclerosis is very useful; Contain cAMP in the Fructus Jujubae, its pharmacological action shows as and improves microcirculation in human body, and coronary artery dilator increases the amount of blood supply of brain and heart, and decreasing heart rate reduces myocardial oxygen consumption and improves the metabolism of ischemic myocardium, so can prevent and treat cardiovascular and cerebrovascular disease.
Radix Rubiae: cold in nature, bitter in the mouth is returned Liver Channel, effect: cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling cures mainly: the heat in blood spitting of blood; Spit blood; Epistaxis; Hematuria; Have blood in stool; Metrorrhagia; Amenorrhea; Postpartum stagnation stomachache; Traumatic injury; Rheumatic arthralgia; Jaundice; Carbuncle sore; Hemorrhoid are swollen, and Radix Rubiae has protective effect to acute myocardial ischemia, and Staphyloccocus aureus, streptococcus pneumoniae, hemophilus influenza are had inhibitory action.
Flos Carthami: warm in nature, acrid in the mouth is gone into, the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, and the effect of stasis-dispelling and pain-killing is used for amenorrhea, dysmenorrhea, and lochia is not all right, the lump in the abdomen mass in the abdomen, injury from falling down, skin infection swell and ache and wait disease, " Bencao Jingshu ": red blue colored, be the key medicine of promoting the circulation of blood.Bruise locked mouth person behind its main product, the edge stagnant blood not down, the contrary last centre of punch, so coma and dizzy and locked mouth are gone into the heart and gone into liver makes stagnant blood descending, then dizzy and locked mouth are from ending.Angor in the abdomen, because stagnant blood is not to the utmost, retention of dead fetus, non-activating blood circulation are then not down; Stasis of blood row then blood is lived, so can end angor, following stillborn fetus also.The medicine of this promoting the circulation of blood of red blue flower also, bruise solution, the row of being detained, namely end, cross with making blood capable more than and get killed, Flos Carthami has slight excited heart, reduce coronary resistance, increase the effect of coronary flow and myocardial nutritional flow amount, and have resisting myocardial ischemia to a certain degree, myocardial infarction and the not normal effect of mental and physical efforts.
The Herba Lycopi: bitter in the mouth, suffering, slightly warm in nature, return liver, spleen channel, effect: blood circulation promoting and blood stasis dispelling, line water detumescence is used for all cards of women's multiparity blood stasis, as amenorrhea, dysmenorrhea, postnatal blood stasis stomachache also is used for edema, ascites, traumatic injury, the treatment of card such as carbuncle skin infection.
Hirudo: salty in the mouth, hardship, property is flat, goes into Liver Channel, effect with removing blood stasis is used for the blood stasis amenorrhea, the treatment of diseases such as lump in the abdomen stomachache, blood-retention, traumatic blood stasis are had a pain, carbuncle erysipelas, Hirudo can be eliminated tremulous pulse week and be raised plaque, increases the myocardial nutrition blood flow, improves arrhythmia.
Radix Ophiopogonis: have another name called Radix Ophiopogonis, Radix Ophiopogonis, fragrant-flowered garlic leaf Radix Ophiopogonis, sweet in the mouth, little hardship, cold nature, go into the heart, lung, stomach warp, the effect that has nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, heat clearing away to nourish heart, being mainly used in pathogenic dryness impairing the lung or lung-dryness syndrome due to deficiency of YIN has the dry cough expectorant of heat glutinous, the chronic cough hemoptysis, dry pharynx dryness in the nasal cavity, lung abscess, dry mouth and throat due to thermal burn stomach-Yin or the deficiency of stomach-Yin, the few tongue of red tongue, vague epigastralgia, interior-heat is quenched one's thirst, constipation due to dry stool, deficiency of heart-yin and epidemic febrile disease pathogenic heat are disturbed and the heart-nutriment and the dysphoria and insomnia that causes, crimson tongue and do and wait card.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel have the diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effect of dispersing cold for relieving pain, the Ramulus Cinnamomi warming the meridian and promoting blood circulation, horizontal logical podomere is used for the affection of exogenous wind-cold exterior syndrome, no matter antiperspirant is arranged, losslessly all can use, also be used for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea, rheumatic arthralgia, cards such as shoulder arm podomere cold type of pain, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, phlegm retention syndromes such as cough with dyspnea dizziness.
Radix Notoginseng: warm in nature, sweet in the mouth, little hardship are returned liver, stomach warp; has hemostasis, dissipating blood stasis, detumescence; the effect of pain relieving cures mainly: control haematemesis, hemoptysis; epistaxis is had blood in stool, dysentery; metrorrhagia, lump in the abdomen, puerperal blood faints; retention of lochia; fall and pounce on blood stasis, traumatic hemorrhage, cards such as carbuncle pain; modern pharmacology proves; Radix Notoginseng can hemostasis, antithrombotic, promotion hemopoietic, antiinflammatory, protect the liver, antitumor, analgesia, cardiovascular is had good effect, and myocardial damage is had protective effect, can reduce serum CK and LDH vigor; reduce LPO content, the protection cardiac muscle.
Semen Coicis: cool in nature, sweet in the mouth, light is returned spleen, stomach, lung meridian.Function with spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic is used for weakness of the spleen and stomach, loose stool diarrhoea, or vaginal discharge diseases of women, and the insufficiency of the spleen leading to overabundance of dampness edema, dysuria, or beriberi swells and ache; Damp and hot arthralgia pain, contracture of the limbs, miserable pain; Lung abscess cough and spit purulent sputum, or enterodynia contracture stomachache." book on Chinese herbal medicine is just ": Semen Coicis, slightly sweet flavor, the feeble QI cold, property edges down and oozes, so the diuretic that can dry is wet with its will, so the weak contracture arthralgia chiefly caused by damp pathogen of flaccidity except beriberi, is controlled in the sharp joint of energy, consumer edema pain, the diuresis pyretic stranguria also kills ascarid.Edge down with it, so also control cough saliva pus, sharp diaphragm appetizing.Cool in nature with it, so the energy heat clearing away ends excessive thirst, goes up gas.But its power is very slow, be assistant make suitable doubly.Semen Coicis can promote the metabolism of body inner blood and moisture, and effects such as diuresis, consumer edema are arranged.
Radix Stephaniae Tetrandrae: bitter in the mouth, suffering, cold in nature, go into bladder, kidney channel; have inducing diuresis to remove edema, the function of wind-expelling pain-stopping is used for edema due to the retention of water-damp in the body; dysuria; cards such as rheumatic arthralgia, Radix Stephaniae Tetrandrae can make myocardial contraction weaken, and the every index of cardiac pump function reduces; coronary artery dilator is arranged, increase the effect of coronary flow; myocardial infarction is had protective effect, and Radix Stephaniae Tetrandrae can also the antiarrhythmic effect, is usually used in angina pectoris.
Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.Function with clearing away heat and cooling blood, eliminating stasis to stop pain is used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, cards such as carbuncle skin infection.
Rhizoma Zingiberis: acrid in the mouth, hot in nature, return spleen, stomach, the heart, lung meridian; Have warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, the dampness expectorant, and the effect of warming the lung to resolve fluid-retention is used for coldness and pain in the epigastrium, vomiting is had loose bowels, and YANG-depletion is fainted contrary, and cold fluid-retention is breathed with cough, cards such as arthralgia due to cold-dampnes, " book on Chinese herbal medicine is high former ": " legendary god of farming's herbal classic " only has Rhizoma Zingiberis Recens, Rhizoma Zingiberis, and do not have Rhizoma Zingiberis Preparatum, and the descendant is black with the Rhizoma Zingiberis big gun, the Rhizoma Zingiberis Preparatum of meaning." Medical Treasures of the Golden Chamber " controls consumptive lung disease Radix Glycyrrhizae Rhizoma Zingiberis soup, and its Rhizoma Zingiberis is big gun also: be the usefulness of Rhizoma Zingiberis Preparatum, Zhong Zuqi elder generation.It is that hot flavor subtracts slightly that Rhizoma Zingiberis Recens this suffering of distinguishing the flavor of, big gun are crossed, and cures mainly blood deficiency fever of the body in puerperal, and interior cold haematemesis, epistaxis, the card of having blood in stool.If concoct too, essence is not deposited, the Rhizoma Zingiberis Recens charcoal of meaning, and its mildly bitter flavor is not hot, and its light weight is floating unreal, again the function of too late Rhizoma Zingiberis Preparatum.Namely use Rhizoma Zingiberis Preparatum, female Rhizoma Zingiberis Recens of also must three thoroughfares becoming civilized begins to effectively.
Semen Lepidii (Semen Descurainiae): acrid in the mouth, hardship, cold in nature, go into lung, the heart, liver, stomach, urinary bladder channel, have the eliminating the pathogens from the lung sending down the abnormal ascending QI, eliminating phlegm and relieving asthma, inducing diuresis to remove edema is let out by evil effect, cures mainly the dyspnea and cough with excessive sputum that sputum is stopped up lung; Lung abscess; Edema; Breast abdomen hydrops; Dysuria; Chronic pulmonary heart disease; Breathing heavily of heart failure is swollen; Scrofula tuberculosis, Semen Lepidii (Semen Descurainiae) have the effect of heart tonifying, can strengthen myocardial contraction.
Further preferred, the described Chinese medicine preparation that is used for the treatment of dilated cardiomyopathy only is made of said components.
Wherein, the ratio of weight and number of various components can be preferably in the side: Radix Codonopsis 30～37 weight portions, the Radix Astragali 40～46 weight portions, Fructus Jujubae 21～25 weight portions, Radix Rubiae 17～23 weight portions, Flos Carthami 23～27 weight portions, Herba Lycopi's 12～18 weight portions, Hirudo 18～22 weight portions, Radix Ophiopogonis 25～32 weight portion, Ramulus Cinnamomi 10～15 weight portions, Radix Notoginseng 20～26 weight portions, Semen Coicis 12～16 weight portions, Radix Stephaniae Tetrandrae 19～23 weight portions, Radix Paeoniae Rubra 8～12 weight portions, Rhizoma Zingiberis 11～15 weight portions and Semen Lepidii (Semen Descurainiae) 13～17 weight portions.
Further, the ratio of weight and number of various components also can be preferably: Radix Codonopsis 34～37 weight portions, the Radix Astragali 42～46 weight portions, Fructus Jujubae 23～25 weight portions, Radix Rubiae 19～23 weight portions, Flos Carthami 25～27 weight portions, Herba Lycopi's 14～18 weight portions, Hirudo 20～22 weight portions, Radix Ophiopogonis 29～32 weight portion, Ramulus Cinnamomi 12～15 weight portions, Radix Notoginseng 24～26 weight portions, Semen Coicis 14～16 weight portions, Radix Stephaniae Tetrandrae 21～23 weight portions, Radix Paeoniae Rubra 10～12 weight portions, Rhizoma Zingiberis 13～15 weight portions and Semen Lepidii (Semen Descurainiae) 15～17 weight portions.
The Chinese medicine preparation that the present invention is used for the treatment of dilated cardiomyopathy can adopt the form of capsule for oral administration, and its preparation method is as follows:
The first step, Radix Codonopsis, the Radix Astragali, Fructus Jujubae and Radix Ophiopogonis are mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, adopt percolation (" Chinese pharmacopoeia version appendix in 2010 I O) with the speed of per minute 1～2ml percolation slowly, collect percolate, being concentrated into relative density is the mastic of 1.29～1.32 (70 ℃), and wherein, the amount of the ethanol of adding is 2～4 times of first step mixture quality;
Second goes on foot, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo and Radix Notoginseng is mixed in proportion, decoct with water twice, the each decoction 1 hour～2 hours, filter respectively, merging filtrate, filtrate is condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of second mixture quality that goes on foot;
The 3rd goes on foot, remaining component is mixed in proportion, and decocts with water twice, decocts 1 hour～2 hours at every turn, filter respectively, merging filtrate, filtrate are condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of the 3rd mixture quality that goes on foot;
The 4th goes on foot, above-mentioned mastic and starch is mixed, the ratio of the quality sum of the quality of described starch and the mastic that obtains is 0.1:1～0.3:1, carry out pelletization treatment, dried subsequently, obtain compound particles, further in compound particles, add magnesium stearate again, the ratio of described magnesium stearate and described compound particles quality is 0.15～100:0.5～100, obtains capsule 's content, described capsule 's content is incapsulated namely get capsule in the housing.
The Chinese medicine preparation that the present invention is used for the treatment of dilated cardiomyopathy can also adopt the mode of oral liquid for oral administration, and its preparation method is as follows:
The first step, Radix Codonopsis, the Radix Astragali, Fructus Jujubae and Radix Ophiopogonis are mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, adopt percolation (" Chinese pharmacopoeia version appendix in 2010 I O) with the speed of per minute 1～2ml percolation slowly, collect percolate, being concentrated into relative density is the mastic of 1.29～1.32 (70 ℃), and wherein, the amount of the ethanol of adding is 2～4 times of first step mixture quality;
Second goes on foot, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo and Radix Notoginseng is mixed in proportion, decoct with water twice, the each decoction 1 hour～2 hours, filter respectively, merging filtrate, filtrate is condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of second mixture quality that goes on foot;
The 3rd goes on foot, remaining component is mixed in proportion, and decocts with water twice, decocts 1 hour～2 hours at every turn, filter respectively, merging filtrate, filtrate are condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of the 3rd mixture quality that goes on foot;
The 4th step, described mastic is mixed, add water, the quality of the water that adds is 1～1.5 times of described mastic mixture quality, mixing, cold preservation 24 hours～48 hours, filter, add cane sugar powder, active carbon in the filtrate, carry out heat treated, filtration treatment, embedding processing, sterilization treatment successively, obtain oral liquid; The weight ratio of described filtrate and cane sugar powder is 1: 0.1～0.3; The weight ratio of described filtrate and active carbon is 1: 0.001～0.002; The described heat treated time is 20～40 minutes, and temperature is 100 ℃～110 ℃, and the crude drug concentration in the described oral liquid is 0.9g/mL～1.5g/mL.
The present invention also provides a kind of healthcare dietetic liquid, and it comprises following component: Radix Codonopsis, the Radix Astragali, Fructus Jujubae, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo, Radix Ophiopogonis, Ramulus Cinnamomi, Radix Notoginseng, Semen Coicis, Radix Stephaniae Tetrandrae, Radix Paeoniae Rubra, Rhizoma Zingiberis and Semen Lepidii (Semen Descurainiae).
Wherein, the ratio of weight and number of various components can be preferably in the side: Radix Codonopsis 30～37 weight portions, the Radix Astragali 40～46 weight portions, Fructus Jujubae 21～25 weight portions, Radix Rubiae 17～23 weight portions, Flos Carthami 23～27 weight portions, Herba Lycopi's 12～18 weight portions, Hirudo 18～22 weight portions, Radix Ophiopogonis 25～32 weight portion, Ramulus Cinnamomi 10～15 weight portions, Radix Notoginseng 20～26 weight portions, Semen Coicis 12～16 weight portions, Radix Stephaniae Tetrandrae 19～23 weight portions, Radix Paeoniae Rubra 8～12 weight portions, Rhizoma Zingiberis 11～15 weight portions and Semen Lepidii (Semen Descurainiae) 13～17 weight portions.
Further, the ratio of weight and number of various components also can be preferably: Radix Codonopsis 34～37 weight portions, the Radix Astragali 42～46 weight portions, Fructus Jujubae 23～25 weight portions, Radix Rubiae 19～23 weight portions, Flos Carthami 25～27 weight portions, Herba Lycopi's 14～18 weight portions, Hirudo 20～22 weight portions, Radix Ophiopogonis 29～32 weight portion, Ramulus Cinnamomi 12～15 weight portions, Radix Notoginseng 24～26 weight portions, Semen Coicis 14～16 weight portions, Radix Stephaniae Tetrandrae 21～23 weight portions, Radix Paeoniae Rubra 10～12 weight portions, Rhizoma Zingiberis 13～15 weight portions and Semen Lepidii (Semen Descurainiae) 15～17 weight portions.
The preparation method of described healthcare dietetic liquid comprises:
The first step, Radix Codonopsis, the Radix Astragali, Fructus Jujubae and Radix Ophiopogonis are mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, adopt percolation (" Chinese pharmacopoeia version appendix in 2010 I O) with the speed of per minute 1～2ml percolation slowly, collect percolate, being concentrated into relative density is the mastic of 1.29～1.32 (70 ℃), wherein, the amount of the ethanol of adding is 2～4 times of first step mixture quality;
Second goes on foot, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo and Radix Notoginseng is mixed in proportion, decoct with water twice, the each decoction 1 hour～2 hours, filter respectively, merging filtrate, filtrate is condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of second mixture quality that goes on foot;
The 3rd goes on foot, remaining component is mixed in proportion, and decocts with water twice, decocts 1 hour～2 hours at every turn, filter respectively, merging filtrate, filtrate are condensed into the mastic that relative density is 1.25～1.27 (70 ℃), and the quality of the water that adds is 2～4 times of the 3rd mixture quality that goes on foot;
The 4th step, described mastic is mixed, add water, the quality of the water that adds is 3～10 times of described mastic mixture qualities, mixing, cold preservation 24 hours～48 hours, filter, add cane sugar powder, active carbon in the filtrate, carry out heat treated, filtration treatment, embedding processing, sterilization treatment successively, obtain oral liquid; The weight ratio of described filtrate and cane sugar powder is 1: 0.1～0.3; The weight ratio of described filtrate and active carbon is 1: 0.001～0.002; The described heat treated time is 20～40 minutes, and temperature is 100 ℃～110 ℃, and the crude drug concentration in the described oral liquid is 0.1g/mL～0.3g/mL.
In order to further specify problem, will above-mentioned preparation process be described by specific embodiment below:
The preparation of embodiment 1 Chinese medicinal capsule agent of the present invention
(1) 340g Radix Codonopsis, the 420g Radix Astragali, 230g Fructus Jujubae and 290g are mixed Radix Ophiopogonis, with determining alcohol be 90% ethanol 4000g as solvent, flooded 18 hours, adopt percolation with the speed of per minute 1ml percolation slowly, collect percolate, being concentrated into relative density is the mastic of 1.32 (70 ℃).
(2) with 190g Radix Rubiae, 250g Flos Carthami, 140g Herba Lycopi, 200g Hirudo and 240g panax mixed, add the 2500g decocting and boil twice, decocted 2 hours at every turn, filter respectively, merging filtrate, filtrate is condensed into the mastic that relative density is 1.25 (70 ℃).
(3) 120g Ramulus Cinnamomi, 140g Semen Coicis, 210g Radix Stephaniae Tetrandrae, 100g Radix Paeoniae Rubra, 130g Rhizoma Zingiberis and 150g Semen Lepidii (Semen Descurainiae) are mixed, add the 2500g decocting and boil twice, decocted 2 hours at every turn, filter respectively, merging filtrate, filtrate are condensed into the mastic that relative density is 1.27 (70 ℃).
(4) above-mentioned mastic and 450g starch are mixed, carry out pelletization treatment, dried subsequently, obtain compound particles, further in compound particles, add the 15g magnesium stearate again, obtain capsule 's content, described capsule 's content is incapsulated namely get capsule in the housing.
The preparation of embodiment 2 Chinese medicine oral liquid of the present invention
(1) 370g Radix Codonopsis, the 460g Radix Astragali, 250g Fructus Jujubae and 320g are mixed Radix Ophiopogonis, with determining alcohol be 90% ethanol 4200g as solvent, flooded 18 hours, adopt percolation with the speed of per minute 1ml percolation slowly, collect percolate, being concentrated into relative density is the mastic of 1.32 (70 ℃).
(2) with 230g Radix Rubiae, 270g Flos Carthami, 180g Herba Lycopi, 220g Hirudo and 260g panax mixed, add the 2600g decocting and boil twice, decocted 2 hours at every turn, filter respectively, merging filtrate, filtrate is condensed into the mastic that relative density is 1.25 (70 ℃).
(3) 150g Ramulus Cinnamomi, 160g Semen Coicis, 230g Radix Stephaniae Tetrandrae, 120g Radix Paeoniae Rubra, 150g Rhizoma Zingiberis and 170g Semen Lepidii (Semen Descurainiae) are mixed, add the 2600g decocting and boil twice, decocted 2 hours at every turn, filter respectively, merging filtrate, filtrate are condensed into the mastic that relative density is 1.27 (70 ℃).
(4) described mastic is mixed, add 3500g water, mixing, cold preservation 48 hours, filter, add 350g cane sugar powder, active 4g charcoal in the filtrate, carry out heat treated, filtration treatment, embedding processing, sterilization treatment successively, wherein, the heat treated time is 20 minutes, heating-up temperature is 110 ℃, obtains oral liquid, and the crude drug concentration in the described oral liquid is 1g/mL.
Embodiment 3 healthcare dietetic liquids of the present invention
(1) 340g Radix Codonopsis, the 420g Radix Astragali, 230g Fructus Jujubae and 290g are mixed Radix Ophiopogonis, with determining alcohol be 90% ethanol 4000g as solvent, flooded 18 hours, adopt percolation with the speed of per minute 1ml percolation slowly, collect percolate, being concentrated into relative density is the mastic of 1.32 (70 ℃).
(2) with 190g Radix Rubiae, 250g Flos Carthami, 140g Herba Lycopi, 200g Hirudo and 240g panax mixed, add the 2500g decocting and boil twice, decocted 2 hours at every turn, filter respectively, merging filtrate, filtrate is condensed into the mastic that relative density is 1.25 (70 ℃).
(3) 120g Ramulus Cinnamomi, 140g Semen Coicis, 210g Radix Stephaniae Tetrandrae, 100g Radix Paeoniae Rubra, 130g Rhizoma Zingiberis and 150g Semen Lepidii (Semen Descurainiae) are mixed, add the 2500g decocting and boil twice, decocted 2 hours at every turn, filter respectively, merging filtrate, filtrate are condensed into the mastic that relative density is 1.27 (70 ℃).
(4) described mastic is mixed, add 30000g water, mixing, cold preservation 48 hours is filtered, add 300g cane sugar powder, 3g active carbon in the filtrate, carry out heat treated, filtration treatment, embedding processing, sterilization treatment successively, wherein, the heat treated time is 20 minutes, heating-up temperature is 110 ℃, obtains healthcare dietetic liquid; Crude drug concentration in the described healthcare dietetic liquid is 0.1g/mL.
Embodiment 4 model cases
Wu, woman, 32 years old, company secretary.The frequent cardiopalmus of oneself statement, slight asthma are month surplus, and walking is that cardiopalmus and asthma increase the weight of more than 20 minutes, and it is unable to feel like jelly with two lower limb, need halt a moment and have a rest.Before this is gone to a doctor, dissatisfied with conventional western medicine, above-mentioned symptom is increased the weight of, put down asthma when crouching night, slight two lower limb pitting edema is arranged.On inspection, electrocardiogram shows that slight ST-T ripple changes and second degree A-V block; Doppler ultrasound detects left atrium, left ventricle obviously enlarges, and the left ventricle contractile function descends, and measures LVEF≤36%.The Chinese medicine oral liquid of continuous application dilated cardiomyopathy of the present invention is after one month, the above-mentioned clinical manifestation of patient begins to fade away, electrocardiographic abnormality significantly improves, doppler ultrasound detects left atrium, left ventricle is contracted to normal border line, measure LVEF＞45%, patient's daily life and work return to normality.
Embodiment 5 concrete clinical experiments
1 case is selected
Dilated cardiomyopathy case 179 examples are included in this research altogether in, all derive from the court in JIUYUE, 2007～2010 year outpatient service in June and inpatient, male's 95 examples wherein, and women's 84 examples, between 30～70 years old age, the course of disease 6 months～7 years.MethodsThe cases enrolled is divided into treatment group and matched group at random, and 129 examples are organized in treatment, matched group 50 examples.In the treatment group, cardiac function II level is organized 69 examples, and cardiac function III level is organized 33 examples, and cardiac function IV level is organized 27 examples, and in the matched group, cardiac function II level is organized 21 examples, and cardiac function III level is organized 17 examples, and cardiac function IV level is organized 12 examples, is the coronary heart disease patient.Two groups of sexes, age, cardiac function, the state of an illness etc. relatively, the difference not statistically significant has comparability.
All meet 1999 " in national myocarditis, the cardiomyopathy seminar to myocardiac diagnosis reference standard ".Get rid of coronary heart disease, valvular heart disease, congenital heart disease, pericardial disease, viral myocarditis, pulmonary heart disease and the clear and definite organic heart disease of other a variety of causes, cardiogenic shock, severe arrhythmia, atrioventricular block, bradycardia (heart rate＜60 time/min), be associated with serious primary disease patient such as liver, kidney and hormonal system and hemopoietic system.
2 Therapeutic Method
Matched group: use enalapril 5mg, 2 times on the 1st; Metoprolol 12. 5～25mg, 2 times on the 1st; Spironolactone 20mg, 1 time on the 1st; FRUSEMIDE 20mg, 1 time on the 1st.
The treatment group: on the basis identical with treatment of control group, oral Chinese medicine oral liquid of the present invention, each 10mL, every day 3 times.
Two groups equal 3 months be a course for the treatment of, treat 2 courses for the treatment of.
3 observation index
Clinical symptoms and sign, cardiac functional grading is (by the USA New York NYHA of heart disease association cardiac functional grading, colored Doppler ultrasonic developing-out unit is observed left ventricular interior diameter diastasis (LVDD), end-systole left atrial diameter LAD and left ventricular ejection mark (LVFE) and is changed, defecation routine, routine blood test, platelet, hepatic and renal function before and after the treatment.
4 criterions of therapeutical effect
Produce effects: cardiac function improves more than the II level, and symptom, sign and every parameters of left ventricular function are significantly improved.Effectively: cardiac function improves more than the I level, and symptom, sign and every parameters of left ventricular function make moderate progress.Invalid: cardiac function does not have obvious improvement or the person of increasing the weight of.
Statistical procedures all adopts SPSS10. 0 software to carry out computing.Measurement data with mean ± standard deviation (
The t check is relatively adopted in ± s) expression between group, (P＜0. 05) have statistical significance for difference.
5 therapeutic outcomes
Two groups of clinical efficacies relatively see Table 1.
Table 1 liang group clinical efficacy relatively
| Group | Number | Produce effects | Effectively | Invalid | Total effective rate (%) |
| The treatment group | 129 | 81 | 42 | 6 | 95.3 |
| Matched group | 50 | 12 | 25 | 13 | 74 |
Compare with matched group, adopt Chinese medicine oral liquid of the present invention on total effective rate and produce effects number, all to have clear improvement.
The more anxious LVEF of left chamber size changes before and after two groups of treatments, sees Table 2.
The table 2 liang left chamber size of group and left ventricular ejection mark (LVEF) comparison (
± s)
Annotate: relatively preceding with the treatment of this group,
*P＜0.05,
*P＜0.01; With comparison after the treatment of control group,
△P＜0.05.
Two groups of untoward reaction are compared, and untoward reaction 2 examples appear in matched group, show as sinus bradycardia 1 example, hypotension 1 example.The treatment group is not found any untoward reaction in therapeutic process.Check defecation routine, routine blood test, platelet, hepatic and renal function have no significant change before and after two groups of treatments.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (6)
1. Chinese medicinal capsule that is used for the treatment of dilated cardiomyopathy, it is characterized in that: described Chinese medicinal capsule is made of Radix Codonopsis, the Radix Astragali, Fructus Jujubae, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo, Radix Ophiopogonis, Ramulus Cinnamomi, Radix Notoginseng, Semen Coicis, Radix Stephaniae Tetrandrae, Radix Paeoniae Rubra, Rhizoma Zingiberis and Semen Lepidii (Semen Descurainiae) combination of components;
The ratio of weight and number of described various components is, Radix Codonopsis 34～37 weight portions, the Radix Astragali 42～46 weight portions, Fructus Jujubae 23～25 weight portions, Radix Rubiae 19～23 weight portions, Flos Carthami 25～27 weight portions, Herba Lycopi's 14～18 weight portions, Hirudo 20～22 weight portions, Radix Ophiopogonis 29～32 weight portion, Ramulus Cinnamomi 12～15 weight portions, Radix Notoginseng 24～26 weight portions, Semen Coicis 14～16 weight portions, Radix Stephaniae Tetrandrae 21～23 weight portions, Radix Paeoniae Rubra 10～12 weight portions, Rhizoma Zingiberis 13～15 weight portions and Semen Lepidii (Semen Descurainiae) 15～17 weight portions.
2. the preparation method of the described Chinese medicinal capsule of claim 1 is characterized in that, comprising:
The first step, Radix Codonopsis, the Radix Astragali, Fructus Jujubae and Radix Ophiopogonis are mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, adopt that " percolation of Chinese pharmacopoeia version appendix in 2010 I O record is with the speed of per minute 1～2ml percolation slowly, collect percolate, relative density is 1.29～1.32 mastic when being concentrated into 70 ℃, and wherein, the amount of the ethanol of adding is 2～4 times of first step mixture quality;
Second goes on foot, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo and Radix Notoginseng is mixed in proportion, decoct with water twice, the each decoction 1 hour～2 hours, filter respectively, merging filtrate, relative density was 1.25～1.27 mastic when filtrate was condensed into 70 ℃, and the quality of the water that adds is 2～4 times of second mixture quality that goes on foot;
The 3rd goes on foot, remaining component is mixed in proportion, and decocts with water twice, decocts 1 hour～2 hours at every turn, filter respectively, relative density was 1.25～1.27 mastic when merging filtrate, filtrate were condensed into 70 ℃, and the quality of the water that adds is 2～4 times of the 3rd mixture quality that goes on foot;
The 4th goes on foot, above-mentioned mastic and starch is mixed, the ratio of the quality sum of the quality of described starch and the mastic that obtains is 0.1:1～0.3:1, carry out pelletization treatment, dried subsequently, obtain compound particles, further in compound particles, add magnesium stearate again, the ratio of described magnesium stearate and described compound particles quality is 0.15～100:0.5～100, obtains capsule 's content, described capsule 's content is incapsulated namely get capsule in the housing.
3. Chinese medicine oral liquid that is used for the treatment of dilated cardiomyopathy, it is characterized in that: described Chinese medicine oral liquid is made of Radix Codonopsis, the Radix Astragali, Fructus Jujubae, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo, Radix Ophiopogonis, Ramulus Cinnamomi, Radix Notoginseng, Semen Coicis, Radix Stephaniae Tetrandrae, Radix Paeoniae Rubra, Rhizoma Zingiberis and Semen Lepidii (Semen Descurainiae) combination of components;
The ratio of weight and number of described various components is, Radix Codonopsis 34～37 weight portions, the Radix Astragali 42～46 weight portions, Fructus Jujubae 23～25 weight portions, Radix Rubiae 19～23 weight portions, Flos Carthami 25～27 weight portions, Herba Lycopi's 14～18 weight portions, Hirudo 20～22 weight portions, Radix Ophiopogonis 29～32 weight portion, Ramulus Cinnamomi 12～15 weight portions, Radix Notoginseng 24～26 weight portions, Semen Coicis 14～16 weight portions, Radix Stephaniae Tetrandrae 21～23 weight portions, Radix Paeoniae Rubra 10～12 weight portions, Rhizoma Zingiberis 13～15 weight portions and Semen Lepidii (Semen Descurainiae) 15～17 weight portions.
4. the preparation method of the described Chinese medicine oral liquid of claim 3 is characterized in that, comprising:
The first step, Radix Codonopsis, the Radix Astragali, Fructus Jujubae and Radix Ophiopogonis are mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, adopt that " percolation of Chinese pharmacopoeia version appendix in 2010 I O record is with the speed of per minute 1～2ml percolation slowly, collect percolate, relative density is 1.29～1.32 mastic when being concentrated into 70 ℃, and wherein, the amount of the ethanol of adding is 2～4 times of first step mixture quality;
Second goes on foot, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo and Radix Notoginseng is mixed in proportion, decoct with water twice, the each decoction 1 hour～2 hours, filter respectively, merging filtrate, relative density was 1.25～1.27 mastic when filtrate was condensed into 70 ℃, and the quality of the water that adds is 2～4 times of second mixture quality that goes on foot;
The 3rd goes on foot, remaining component is mixed in proportion, and decocts with water twice, decocts 1 hour～2 hours at every turn, filter respectively, relative density was 1.25～1.27 mastic when merging filtrate, filtrate were condensed into 70 ℃, and the quality of the water that adds is 2～4 times of the 3rd mixture quality that goes on foot;
The 4th step, described mastic is mixed, add water, the quality of the water that adds is 1～1.5 times of described mastic mixture quality, mixing, cold preservation 24 hours～48 hours, filter, add cane sugar powder, active carbon in the filtrate, carry out heat treated, filtration treatment, embedding processing, sterilization treatment successively, obtain oral liquid; The weight ratio of described filtrate and cane sugar powder is 1: 0.1～0.3; The weight ratio of described filtrate and active carbon is 1: 0.001～0.002; The described heat treated time is 20～40 minutes, and temperature is 100 ℃～110 ℃, and the crude drug concentration in the described oral liquid is 0.9g/mL～1.5g/mL.
5. healthcare dietetic liquid, it is characterized in that: described healthcare dietetic liquid is made of Radix Codonopsis, the Radix Astragali, Fructus Jujubae, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo, Radix Ophiopogonis, Ramulus Cinnamomi, Radix Notoginseng, Semen Coicis, Radix Stephaniae Tetrandrae, Radix Paeoniae Rubra, Rhizoma Zingiberis and Semen Lepidii (Semen Descurainiae) combination of components;
The ratio of weight and number of described various components is, Radix Codonopsis 34～37 weight portions, the Radix Astragali 42～46 weight portions, Fructus Jujubae 23～25 weight portions, Radix Rubiae 19～23 weight portions, Flos Carthami 25～27 weight portions, Herba Lycopi's 14～18 weight portions, Hirudo 20～22 weight portions, Radix Ophiopogonis 29～32 weight portion, Ramulus Cinnamomi 12～15 weight portions, Radix Notoginseng 24～26 weight portions, Semen Coicis 14～16 weight portions, Radix Stephaniae Tetrandrae 21～23 weight portions, Radix Paeoniae Rubra 10～12 weight portions, Rhizoma Zingiberis 13～15 weight portions and Semen Lepidii (Semen Descurainiae) 15～17 weight portions.
6. the preparation method of the described healthcare dietetic liquid of claim 5 is characterized in that, comprising:
The first step, Radix Codonopsis, the Radix Astragali, Fructus Jujubae and Radix Ophiopogonis are mixed in proportion, be that 80%～90% ethanol is as solvent with determining alcohol, flooded 12 hours～18 hours, adopt that " percolation of Chinese pharmacopoeia version appendix in 2010 I O record is collected percolate with the speed of per minute 1～2ml percolation slowly, and relative density is 1.29～1.32 mastic when being concentrated into 70 ℃, wherein, the amount of the ethanol of adding is 2～4 times of first step mixture quality;
Second goes on foot, Radix Rubiae, Flos Carthami, Herba Lycopi, Hirudo and Radix Notoginseng is mixed in proportion, decoct with water twice, the each decoction 1 hour～2 hours, filter respectively, merging filtrate, relative density was 1.25～1.27 mastic when filtrate was condensed into 70 ℃, and the quality of the water that adds is 2～4 times of second mixture quality that goes on foot;
The 3rd goes on foot, remaining component is mixed in proportion, and decocts with water twice, decocts 1 hour～2 hours at every turn, filter respectively, relative density was 1.25～1.27 mastic when merging filtrate, filtrate were condensed into 70 ℃, and the quality of the water that adds is 2～4 times of the 3rd mixture quality that goes on foot;
The 4th step, described mastic is mixed, add water, the quality of the water that adds is 3～10 times of described mastic mixture qualities, mixing, cold preservation 24 hours～48 hours, filter, add cane sugar powder, active carbon in the filtrate, carry out heat treated, filtration treatment, embedding processing, sterilization treatment successively, obtain oral liquid; The weight ratio of described filtrate and cane sugar powder is 1: 0.1～0.3; The weight ratio of described filtrate and active carbon is 1: 0.001～0.002; The described heat treated time is 20～40 minutes, and temperature is 100 ℃～110 ℃, and the crude drug concentration in the described oral liquid is 0.1g/mL～0.3g/mL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210024617 CN102526673B (en) | 2012-02-06 | 2012-02-06 | Chinese medicine capsule, Chinese medicine liquid and health-care oral liquid for treating dilated cardiomyopathy and manufacture method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210024617 CN102526673B (en) | 2012-02-06 | 2012-02-06 | Chinese medicine capsule, Chinese medicine liquid and health-care oral liquid for treating dilated cardiomyopathy and manufacture method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102526673A CN102526673A (en) | 2012-07-04 |
| CN102526673B true CN102526673B (en) | 2013-09-04 |
Family
ID=46335490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210024617 Expired - Fee Related CN102526673B (en) | 2012-02-06 | 2012-02-06 | Chinese medicine capsule, Chinese medicine liquid and health-care oral liquid for treating dilated cardiomyopathy and manufacture method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102526673B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102824612B (en) * | 2012-09-20 | 2013-09-11 | 河南中医学院 | Traditional Chinese medicine for treating dilated cardiomyopathy |
| CN104510906A (en) * | 2014-12-23 | 2015-04-15 | 仲崇媛 | Traditional Chinese medicine composition for assisting in preventing and treating cardiomyopathy |
| CN105343358A (en) * | 2015-12-18 | 2016-02-24 | 高松武 | Traditional Chinese medicine capsules for treating coronary heart disease |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305844A (en) * | 2001-01-14 | 2001-08-01 | 刘红 | Medicine for treating congestive heart failure |
| CN101322801A (en) * | 2007-06-15 | 2008-12-17 | 河北以岭医药研究院有限公司 | Use of Chinese medicinal composition in preparing medicament for treating dilated cardiomyopathy |
| CN102038864A (en) * | 2009-10-13 | 2011-05-04 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal composition in preparation of medicament for treating diabetic cardiomyopathy |
-
2012
- 2012-02-06 CN CN 201210024617 patent/CN102526673B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305844A (en) * | 2001-01-14 | 2001-08-01 | 刘红 | Medicine for treating congestive heart failure |
| CN101322801A (en) * | 2007-06-15 | 2008-12-17 | 河北以岭医药研究院有限公司 | Use of Chinese medicinal composition in preparing medicament for treating dilated cardiomyopathy |
| CN102038864A (en) * | 2009-10-13 | 2011-05-04 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal composition in preparation of medicament for treating diabetic cardiomyopathy |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102526673A (en) | 2012-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102772748B (en) | Traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis and preparation method thereof | |
| CN103169862A (en) | Traditional Chinese medicine formula for treating vital myocarditis | |
| CN103169923B (en) | Traditional Chinese medicine composition for treating myocarditis and preparation method of traditional Chinese medicine composition | |
| CN103520680B (en) | The Chinese medicine for the treatment of acute heart failure | |
| CN103705884A (en) | Traditional Chinese medicinal composition for treating bronchial asthma | |
| CN101249243A (en) | Chinese medicine for curing acute leukemia | |
| CN104873705A (en) | Medicinal composition for treating angina pectoris of coronary heart disease and application thereof | |
| CN102526673B (en) | Chinese medicine capsule, Chinese medicine liquid and health-care oral liquid for treating dilated cardiomyopathy and manufacture method | |
| CN104758353A (en) | Medicine composition for treating cardiovascular diseases, preparation method and application thereof | |
| CN104606580A (en) | Traditional Chinese medicine preparation with synergistic effect on chemotherapy and preparation method of traditional Chinese medicine preparation traditional Chinese medicine preparation | |
| CN104771697A (en) | Pharacetuical composition for treating cholecystitis | |
| CN104707090A (en) | Chinese herbal formula for treating coronary heart disease | |
| CN104189429A (en) | Traditional Chinese medicine for treating chronic pulmonary heart disease | |
| CN101584805B (en) | Chinese medicine preparation for treating heart failure | |
| CN103028093A (en) | Traditional Chinese medicine composition for treating chronic obstructive pulmonary emphysema and preparation method of traditional Chinese medicine composition | |
| CN105902897A (en) | Pharmaceutical preparation for treating pancreatic cancer and application thereof | |
| CN104116908A (en) | A traditional Chinese medicine decoction for treating arrhythmia | |
| CN104127670A (en) | Traditional Chinese medicine decoction for treating arrhythmia | |
| CN104524461A (en) | Medicine composition for treating myocarditis and application thereof | |
| CN104367984A (en) | Traditional Chinese medicine formula for treating aged coronary heart disease | |
| CN103961603B (en) | Traditional Chinese medicine preparationcapable of reducing blood fat and freeing vessels | |
| CN116672377B (en) | A Chinese medicinal composition for treating heart failure, preventing and treating asthenia and heart failure decompensation attack, and its preparation method | |
| CN107875252A (en) | A kind of Chinese medicine composition for treating chronic heart failure, and its production and use | |
| CN102895506B (en) | Traditional Chinese medicine granular capsule for treating chronic cardiac failure | |
| CN102488804A (en) | Traditional Chinese medicine for treating cirrhosis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wang Jian Inventor after: Yue Yuan Inventor after: Zhao Zhentao Inventor after: Chen Tao Inventor before: Wang Jian Inventor before: Yue Yuan Inventor before: Zhao Zhentao Inventor before: Chen Tao |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130904 Termination date: 20150206 |
|
| EXPY | Termination of patent right or utility model |