CN105168673A - Medicine for treating hypertension characterized in diastolic blood pressure increase and preparation method of medicine - Google Patents

Abstract

The invention discloses a medicine for treating hypertension characterized in diastolic blood pressure increase and a preparation method of the medicine. The medicine is mainly prepared from lotus leaves, hawthorn fruit, oriental waterplantain rhizomes, cassia seeds, sunflower receptacles and eucommia bark in a specific weight ratio. The medicine for treating the hypertension characterized in diastolic blood pressure increase is capable of clearing summer-heat and damp, tonifying the liver, reinforcing the kidney, activating blood to promote menstruation, promoting urination and freeing orifices, and is quick to take action, good in treatment effect and free from toxic or side effect when being used for treating the hypertension.

Description

A kind of hypertensive medicine and preparation method thereof for the treatment of diastolic pressure and raising

Technical field

The present invention designs one and treats hypertensive medicine, belongs to the field of Chinese medicines.

Background technology

Hypertension is a kind of clinical common syndrome increased based on systemic arterial blood pressure, adult normal's blood pressure systolic pressure >=140 or diastolic pressure >=90mmHg, and just diagnosable is hypertension.Hypertension initial stage development be one asymptomatic, without uncomfortable sensation, the long process of silently carrying out, is referred to as noiseless killer, the heart, brain, kidney damage are modal complication, and the cerebral hemorrhage caused late period, heart failure, renal insufficiency are all very serious.Belong to the categories such as the headache of the traditional Chinese medical science, dizzy, liver-wind.Current Western medicine effectively cannot effect a radical cure hypertension, and need take medicine throughout one's life.

Summary of the invention

Therefore there is great demand to effectively treating hypertensive Chinese medicine in people, also do not find any relevant report about pharmaceutical composition of the present invention up to now.The present inventor through research repeatedly, and passes through the checking repeatedly of clinical trial, finally have found the hypertensive medicine for the treatment of of better curative effect, thus completes the present invention.

Object of the present invention is just to provide the hypertensive Chinese medicine composition of a kind of effectively treatment.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicament selection Folium Nelumbinis of the present invention, Fructus Crataegi, Rhizoma Alismatis, Semen Cassiae, Receptaculum Helianthi, the Cortex Eucommiae, Herba Taxilli, Radix Salviae Miltiorrhizae and Caulis Polygoni Multiflori carry out combining, made by these drug regimens each efficacy of drugs produce synergism, thus can effectively treat hypertensive recurrence.Wherein select Folium Nelumbinis to be because its nature and flavor are pained, flat, enter the heart, liver, spleen channel, have clearing away summer-heat and eliminating dampness, sending up the lucid YANG, the function of hemostasis, control diarrhea due to summer heat and dampness, dizzy, aqueous vapor edema, thunder-headache, spit blood, epistaxis, metrorrhagia, has blood in stool, puerperal blood faints.Select Fructus Crataegi be because its nature and flavor acid sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate.Select Rhizoma Alismatis to be that cold, enter urinary bladder channel, have diuretic, eliminating dampness by diuresis, the function expelled the heat-evil, controls dysuria because its nature and flavor are sweet, edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Semen Cassiae is selected to be because its property bitter but sweet flavor, cool, enter liver, kidney channel, have liver heat removing, improving eyesight, diuretic, the function of relieving constipation, control wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, liver cirrhosis abdomen, habitual constipation.Select Receptaculum Helianthi to be that have diuresis, clearing away damp-heat, sensible, the function reduced blood pressure, controls headache, blurred vision because it is sweet in flavor and warm in property, toothache, stomach is suffered from abdominal pain, woman month dysmenorrhoea, and skin ulcer swells.The Cortex Eucommiae is selected to be that micro-pungent temperature, enters Liver and kidney warp, have invigorating the liver and kidney, bone and muscle strengthening, and antiabortive function, controls ache of the spinal column, foot and knee flaccidity, dribbling urination, and uncontrolled urination is itched because its nature and flavor are sweet, vaginal bleeding during pregnancy wish pendant, hypertension.Select Herba Taxilli to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive function, controls soreness of waist and knee joint, and muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Select Radix Salviae Miltiorrhizae to be that be slightly cold, GUIXIN, Liver Channel, have blood stasis removing pain relieving, promoting blood circulation to remove obstruction in the collateral, and the function of the relieving restlessness that clears away heart-fire, controls angina pectoris because its nature and flavor are bitter, for menoxenia, amenorrhea, dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Select Caulis Polygoni Multiflori to be because its property sweet and slightly bitter taste, flat, enter the heart, Liver Channel, nourish heart, calm the nerves, dredging collateral, the function of dispeling the wind, controls insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.

Detailed description of the invention

The consumption of drug component of the present invention is also through inventor and gropes in a large number to sum up and draw, the consumption of each medicine all has good therapeutic effect within the scope of following weight:

Folium Nelumbinis 130-180g, Fructus Crataegi 280-320g, Rhizoma Alismatis 130-180g, Semen Cassiae 130-180g, Receptaculum Helianthi 560-620g, Cortex Eucommiae 130-180g, Herba Taxilli 130-180g, Radix Salviae Miltiorrhizae 280-320g, Caulis Polygoni Multiflori 280-320g.

Be preferably: Folium Nelumbinis 150g, Fructus Crataegi 300g, Rhizoma Alismatis 150g, Semen Cassiae 150g, Receptaculum Helianthi 600g, Cortex Eucommiae 150g, Herba Taxilli 150g, Radix Salviae Miltiorrhizae 300g, Caulis Polygoni Multiflori 300g.

The preparation method of medicine of the present invention is as follows:

One, get the raw materials ready

1, Folium Nelumbinis: clean with water, cut off the base of a fruit and edge, shredding, dry;

2, Fructus Crataegi: pick clean impurity, sieve enucleation;

3, Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;

4, Semen Cassiae: get clean Semen Cassiae, putting in pot to fry has fragrance to micro-, takes out, cools;

5, Receptaculum Helianthi: get sunflower disc, removes seed, and stripping and slicing is dried;

6, the Cortex Eucommiae: get Cortex Eucommiae block or strand, add boiled water with Sal, is dissolved and makes fully to mix absorption with saline, then put in pot, with slow fire fry to micro-have focal spot, taking-up is dried; Every Cortex Eucommiae 100 jin Sal 3 jin;

7, Herba Taxilli: wash, runs through, and cutting is dried;

8, Radix Salviae Miltiorrhizae: get crude drug, removes residual stem, impurity, cleans, runs through, cut sheet, dry, and sieve removes chip;

9, Caulis Polygoni Multiflori: clear water is cleaned, and slightly soak, pull out, after running through, cutting, dries;

Two, prepare

1, the preparation of medicament capsule of the present invention:

(1) Folium Nelumbinis cooked, Fructus Crataegi, Rhizoma Alismatis, Semen Cassiae, Receptaculum Helianthi, the Cortex Eucommiae, Herba Taxilli, Radix Salviae Miltiorrhizae, Caulis Polygoni Multiflori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

(3) dry extract is broken into powder, incapsulates.

2, the preparation of medicinal granule of the present invention:

(1) Folium Nelumbinis cooked, Fructus Crataegi, Rhizoma Alismatis, Semen Cassiae, Receptaculum Helianthi, the Cortex Eucommiae, Herba Taxilli, Radix Salviae Miltiorrhizae, Caulis Polygoni Multiflori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

(3) dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule.

3, the preparation of medicinal tablet of the present invention:

(1) Folium Nelumbinis cooked, Fructus Crataegi, Rhizoma Alismatis, Semen Cassiae, Receptaculum Helianthi, the Cortex Eucommiae, Herba Taxilli, Radix Salviae Miltiorrhizae, Caulis Polygoni Multiflori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

(3) dry extract is broken into fine powder, adds adjuvant and make granule, tabletted.

Semen Cassiae liver heat removing in prescription, improving eyesight, it is monarch drug that hypertension is controlled in diuretic relieving constipation; Receptaculum Helianthi clearing away damp-heat, sensible, blood pressure lowering, Radix Salviae Miltiorrhizae has promoting blood circulation to restore menstrual flow, and both functions of the relieving restlessness that clears away heart-fire are ministerial drug, and three taste medicines play liver heat removing jointly, diuretic is invigorated blood circulation, the effect of stimulating the menstrual flow, and with the sensible blood pressure lowering of heat clearing away for master can be effected a permanent cure, the Cortex Eucommiae has invigorating the liver and kidney, bone and muscle strengthening, and treating hypertensive function is adjuvant drug, Folium Nelumbinis clearing away summer-heat and eliminating dampness, sending up the lucid YANG, controls heat-damp in summer, dizzy for making medicine, all medicines take stopgap measures with being left.

Medicine of the present invention has clearing away summer-heat and eliminating dampness, tonifying liver, kidney tonifying, promoting blood circulation to restore menstrual flow, the function that diuretic is sensible, and treatment hypertension instant effect, good effect, has no side effect, and does not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity report and the clinical observation material of medicine of the present invention.

[test example 1] animal toxicity test is reported:

Get new zealand rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Take granule, super quantity group is 0.2g/kg, and normal amount is 0.1g/kg, and administering mode is the administration of dilution administration by gavage, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect data of [test example 2] medicine of the present invention

1, physical data

Accept out-patient totally 36 people for medical treatment, wherein: systolic pressure >=140, diastolic pressure >=9520 people.Systolic pressure >=140, diastolic pressure >=10016 people.

2, diagnostic criteria

Adult, comprises old people systolic pressure >=140 or diastolic pressure >=90mmg, and reach above-mentioned standard more than 3 times or 3 times not having in repetitive measurement on the same day, just diagnosable is hypertension.Clinically commonly to have a headache, dizzy, insomnia, tinnitus.

3, Therapeutic Method

Select above-mentioned capsule, granule or tablet any one dosage form, take to patient, every day three times, each 4g, serve on 3 courses for the treatment of, 15 days each courses for the treatment of.

4, efficacy assessment standard

Effective: blood pressure recovers normal; 3 years without recurrence;

Take a turn for the better: headache, dizzy phenomenon alleviates, and sleep quality takes a turn for the better, and blood pressure progressively recovers normal.

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, with hyperpietic 36 people that Drug therapy diastolic pressure of the present invention is higher, effective 33 people of result, obvious effective rate is 91.67%, and take a turn for the better 2 people, and improvement rate is 5.55%, invalid 1 people, and total effective rate is 97.22%.

Claims (3)

1. treat the hypertensive medicine that diastolic pressure raises, it is characterized in that, it is made up of the crude drug in following weight range:

Folium Nelumbinis 130-180g, Fructus Crataegi 280-320g, Rhizoma Alismatis 130-180g, Semen Cassiae 130-180g, Receptaculum Helianthi 560-620g, Cortex Eucommiae 130-180g, Herba Taxilli 130-180g, Radix Salviae Miltiorrhizae 280-320g, Caulis Polygoni Multiflori 280-320g.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Folium Nelumbinis 150g, Fructus Crataegi 300g, Rhizoma Alismatis 150g, Semen Cassiae 150g, Receptaculum Helianthi 600g, Cortex Eucommiae 150g, Herba Taxilli 150g, Radix Salviae Miltiorrhizae 300g, Caulis Polygoni Multiflori 300g.

3. the preparation method of medicine according to claim 1 or 2, it is characterized in that, it comprises the following steps:

One, get the raw materials ready

(1) Folium Nelumbinis: clean with water, cut off the base of a fruit and edge, shredding, dry;

(2) Fructus Crataegi: pick clean impurity, sieve enucleation;

(3) Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;

(4) Semen Cassiae: get clean Semen Cassiae, putting in pot to fry has fragrance to micro-, takes out, cools;

(5) Receptaculum Helianthi: get sunflower disc, removes seed, and stripping and slicing is dried;

(6) Cortex Eucommiae: get Cortex Eucommiae block or strand, add boiled water with Sal, is dissolved and makes fully to mix absorption with saline, then put in pot, with slow fire fry to micro-have focal spot, taking-up is dried; Every Cortex Eucommiae 100 jin Sal 3 jin;

(7) Herba Taxilli: wash, runs through, and cutting is dried;

(8) Radix Salviae Miltiorrhizae: get crude drug, removes residual stem, impurity, cleans, runs through, cut sheet, dry, and sieve removes chip;

(9) Caulis Polygoni Multiflori: clear water is cleaned, and slightly soak, pull out, after running through, cutting, dries;

Two, prepare

(1) preparation of medicament capsule of the present invention:

(1) Folium Nelumbinis cooked, Fructus Crataegi, Rhizoma Alismatis, Semen Cassiae, Receptaculum Helianthi, the Cortex Eucommiae, Herba Taxilli, Radix Salviae Miltiorrhizae, Caulis Polygoni Multiflori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

(3) dry extract is broken into powder, incapsulates;

(2) preparation of medicinal granule of the present invention:

(1) Folium Nelumbinis cooked, Fructus Crataegi, Rhizoma Alismatis, Semen Cassiae, Receptaculum Helianthi, the Cortex Eucommiae, Herba Taxilli, Radix Salviae Miltiorrhizae, Caulis Polygoni Multiflori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

(3) dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule;

(3) preparation of medicinal tablet of the present invention:

(1) Folium Nelumbinis cooked, Fructus Crataegi, Rhizoma Alismatis, Semen Cassiae, Receptaculum Helianthi, the Cortex Eucommiae, Herba Taxilli, Radix Salviae Miltiorrhizae, Caulis Polygoni Multiflori are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

(3) dry extract is broken into fine powder, adds adjuvant and make granule, tabletted.