CN111084865A

CN111084865A - Pharmaceutical composition for postpartum recovery and preparation method and application thereof

Info

Publication number: CN111084865A
Application number: CN202010027111.7A
Authority: CN
Inventors: 王琳; 陈煜峰
Original assignee: Affiliated Hospital of University of Qingdao
Current assignee: Affiliated Hospital of University of Qingdao
Priority date: 2020-01-10
Filing date: 2020-01-10
Publication date: 2020-05-01

Abstract

The invention discloses a pharmaceutical composition for postpartum recovery, a preparation method and application thereof, wherein the composition preferably comprises the following components: 30 parts of codonopsis pilosula, 15 parts of poria cocos, 15 parts of bighead atractylodes rhizome, 12 parts of honey-fried licorice root, 20 parts of prepared rehmannia root, 15 parts of Chinese angelica, 15 parts of white paeony root, 10 parts of ligusticum wallichii, 12 parts of morinda officinalis, 15 parts of herba epimedii, 12 parts of cistanche, 10 parts of schisandra chinensis, 6 parts of cinnamomum wilsonii, 20 parts of astragalus mongholicus, 5 parts of ginseng, 15 parts of medlar, 6 parts of fructus amomi, 10 parts of fingered citron, 15 parts of Chinese dates, 10 parts of cassia twig and 10 parts of. The invention also provides a preparation method and application of the composition. The traditional Chinese medicine composition has the characteristics of reasonable formula, small dosage, remarkable effect, no toxic or side effect and the like, has the effects of warming and invigorating spleen and kidney, nourishing liver and enriching blood, strengthening and transporting middle soil, raising yang and sinking, consolidating exterior and recovering old, losing weight and retaining youthful looks and the like, can effectively adjust the postpartum body state of women, and achieves a good rehabilitation effect.

Description

Pharmaceutical composition for postpartum recovery and preparation method and application thereof

Technical Field

The invention relates to a composition, a preparation method and application thereof, in particular to a pharmaceutical composition for postpartum rehabilitation, and a preparation method and application thereof.

Background

Rehabilitation is a big concept, and all the rehabilitation concepts adopt certain intervention and treatment aiming at the malfunction of human body. The postpartum recovery means that after the female finishes producing, the body of the female is often too weak and needs a certain amount of recovery and maintenance, and the recovery and maintenance is called postpartum recovery.

During pregnancy and childbirth, the uterus gradually enlarges, the pelvic floor muscles and the pelvis, including the spine, are greatly affected, and the body changes correspondingly. The chronic injury also needs to be recovered slowly after delivery, but in the recovery process, many women not only need to take the child and hold the child painstakingly, but also need to do housework everyday, and the heavy labor can cause the pelvis or the spine and the muscle which are originally in the relaxation stage to generate heavy load, thereby causing some adverse effects. If this effect is long-term, instability of the pelvis and spine occurs, which may lead to problems of leakage of urine, relaxation, constipation, incontinence, and chronic low back pain. For example, lumbar disc herniation, lumbar muscle strain, the root cause of which may be pregnancy and childbirth. After delivery, the symptoms of limb weakness, abdominal distension, obesity, headache, sweating, fear of wind and cold, poor uterine involution and the like can be caused, so that corresponding assessment is needed in the postpartum process, and rehabilitation treatment is carried out in time, so that the injury caused by pregnancy and delivery can be recovered better, faster and more comprehensively.

Disclosure of Invention

The invention aims to provide a composition, a preparation method and application thereof, which can solve the existing problems, have the effects of warming and invigorating spleen and kidney, strengthening and transporting middle-jiao, raising yang and sinking, consolidating superficial resistance and recovering from old, can effectively adjust the postpartum state of women, have good recovery effect, and have the characteristics of reasonable formula, small dosage, remarkable effect, no toxic or side effect and the like.

In order to achieve the above objects, the present invention provides a pharmaceutical composition for postpartum recovery, wherein the composition comprises: codonopsis pilosula, poria cocos, bighead atractylodes rhizome, honey-fried licorice root, prepared rehmannia root, Chinese angelica, white paeony root, ligusticum wallichii, morinda officinalis, herba epimedii, cistanche, schisandra chinensis, cinnamomum wilsonii, astragalus mongholicus, ginseng, medlar, fructus amomi, fingered citron, Chinese date, cassia twig and donkey-hide gelatin.

The pharmaceutical composition for postpartum recovery comprises the following components in parts by weight: 25-35 parts of codonopsis pilosula, 12-18 parts of poria cocos, 12-18 parts of bighead atractylodes rhizome, 10-15 parts of honey-fried licorice root, 18-22 parts of prepared rehmannia root, 12-18 parts of Chinese angelica, 12-18 parts of white peony root, 8-12 parts of ligusticum wallichii, 10-15 parts of morinda officinalis, 12-18 parts of epimedium, 10-15 parts of cistanche, 8-12 parts of schisandra chinensis, 4-8 parts of cinnamomum wilsonii, 18-22 parts of astragalus membranaceus, 3-7 parts of ginseng, 12-18 parts of medlar, 4-8 parts of fructus amomi, 8-12 parts of fingered citron, 12-18 parts of Chinese date, 8-12 parts of cassia twig and 8-12 parts of donkey-.

The pharmaceutical composition for postpartum recovery comprises the following components in parts by weight: 30 parts of codonopsis pilosula, 15 parts of poria cocos, 15 parts of bighead atractylodes rhizome, 12 parts of honey-fried licorice root, 20 parts of prepared rehmannia root, 15 parts of Chinese angelica, 15 parts of white paeony root, 10 parts of ligusticum wallichii, 12 parts of morinda officinalis, 15 parts of herba epimedii, 12 parts of cistanche, 10 parts of schisandra chinensis, 6 parts of cinnamomum wilsonii, 20 parts of astragalus mongholicus, 5 parts of ginseng, 15 parts of medlar, 6 parts of fructus amomi, 10 parts of fingered citron, 15 parts of Chinese dates, 10 parts of cassia twig and 10 parts of.

The invention also provides a preparation method of the pharmaceutical composition for postpartum rehabilitation, wherein the method comprises the following steps: weighing the raw materials in proportion, processing after respectively cleaning, grinding and crushing, then putting all the raw materials into a container, adding water for soaking, heating and decocting until the raw materials become thick paste, cooling and cooling. Preferably, the method further comprises soaking in water, decocting under heating, cooling, and filtering to remove residue; wherein the time for heating and decocting is preferably 40-60 min.

The preparation method of the pharmaceutical composition for postpartum recovery comprises the step of grinding and crushing, wherein the particle size range of the ground and crushed pharmaceutical composition is 50-80 meshes.

The preparation method of the pharmaceutical composition for postpartum rehabilitation is characterized in that the soaking in water in the method is carried out for 30-40 minutes by adding distilled water which is 6-10 times of the total amount of the medicines by weight.

The invention also provides the application of the composition prepared by the method, wherein the composition is used for preparing an oral preparation for postpartum rehabilitation.

The composition is used in the preparation of a medicament for treating diabetes, wherein the preparation comprises an internal paste formula.

The composition is used, wherein the ointment is taken from one week after delivery, and the treatment course is 3-6 months.

The composition is used, wherein the ointment formula is taken in the morning and evening, and 6-9 g of the ointment formula is taken each time.

The pharmaceutical composition for postpartum recovery, the preparation method and the application thereof provided by the invention have the following advantages:

the invention starts from the 'cold' of shaoyin and the 'deficiency' of taiyin, the morinda officinalis, the herba epimedii, the cistanche deserticola and the cinnamon warm tonify the fire of the Mingmen, and the medlar, the schisandra chinensis, the donkey-hide gelatin and the honey nourish the yin of the liver and the kidney, strengthen the function of sealing the liver and the kidney and preserve the fire; the Sijunzi decoction helps to nourish middle-jiao and spleen and nourish blood; fructus Amomi and fructus Citri Sarcodactylis can be added to regulate qi stagnation to prevent stomach obstruction and phlegm stagnation. The postpartum rehabilitation is carried out by 'internal and external regulation', and the effects of warming and invigorating spleen and kidney, nourishing liver and replenishing blood, strengthening and transporting middle-jiao, lifting yang and sinking, consolidating superficial resistance and recovering old, losing weight and retaining youthful looks can be achieved by starting from three channels of shaoyin channel, Taiyin channel and Taiyang channel.

The composition provided by the invention has the advantages of reasonable formula, small dosage, obvious effect and the like, can effectively regulate the postpartum state of women, has good rehabilitation effect, does not have adverse reaction and side effect, and can strengthen physique, enhance physical strength, improve immunity, supplement energy, revive spirit, improve sleep and the like. Meanwhile, the health-care tea has the characteristics of pure nature, no additive, no toxic or side effect of plant herbs, no harm to bodies and the like, and is obviously superior to products with similar functions.

Detailed Description

The following further describes embodiments of the present invention.

The pharmaceutical composition for postpartum recovery provided by the invention comprises: codonopsis pilosula, poria cocos, bighead atractylodes rhizome, honey-fried licorice root, prepared rehmannia root, Chinese angelica, white paeony root, ligusticum wallichii, morinda officinalis, herba epimedii, cistanche, schisandra chinensis, cinnamomum wilsonii, astragalus mongholicus, ginseng, medlar, fructus amomi, fingered citron, Chinese date, cassia twig and donkey-hide gelatin.

Preferably, the composition comprises, in parts by weight: 25-35 parts of codonopsis pilosula, 12-18 parts of poria cocos, 12-18 parts of bighead atractylodes rhizome, 10-15 parts of honey-fried licorice root, 18-22 parts of prepared rehmannia root, 12-18 parts of Chinese angelica, 12-18 parts of white peony root, 8-12 parts of ligusticum wallichii, 10-15 parts of morinda officinalis, 12-18 parts of epimedium, 10-15 parts of cistanche, 8-12 parts of schisandra chinensis, 4-8 parts of cinnamomum wilsonii, 18-22 parts of astragalus membranaceus, 3-7 parts of ginseng, 12-18 parts of medlar, 4-8 parts of fructus amomi, 8-12 parts of fingered citron, 12-18 parts of Chinese date, 8-12 parts of cassia twig and 8-12 parts of donkey-.

More preferably, the composition comprises, in parts by weight: 30 parts of codonopsis pilosula, 15 parts of poria cocos, 15 parts of bighead atractylodes rhizome, 12 parts of honey-fried licorice root, 20 parts of prepared rehmannia root, 15 parts of Chinese angelica, 15 parts of white paeony root, 10 parts of ligusticum wallichii, 12 parts of morinda officinalis, 15 parts of herba epimedii, 12 parts of cistanche, 10 parts of schisandra chinensis, 6 parts of cinnamomum wilsonii, 20 parts of astragalus mongholicus, 5 parts of ginseng, 15 parts of medlar, 6 parts of fructus amomi, 10 parts of fingered citron, 15 parts of Chinese dates, 10 parts of cassia twig and 10 parts of.

Wherein the radix Codonopsis is dried root of radix Codonopsis, radix Codonopsis Lanceolatae, or radix Codonopsis Lanceolatae of Campanulaceae. Sweet and mild in nature and taste, has the effects of invigorating spleen and replenishing qi, regulating stomach function and promoting fluid production, eliminating phlegm and relieving cough, and is used for treating spleen deficiency, anorexia, loose stool, myasthenia of limbs, palpitation, short breath, dry mouth, spontaneous perspiration, rectocele, and abnormal yin, and invigorating primordial qi.

Poria is dried sclerotium of Poria cocos (Schw.) wolf of Polyporaceae. Sweet and bland in flavor, neutral in nature, and entering heart, lung, spleen and kidney meridians. Has effects in promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. It can be used for treating edema, oliguria, palpitation due to phlegm and fluid retention, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.

Atractylodis rhizoma belongs to perennial herb of Compositae and Atractylodes, and is used as Chinese medicinal material, which is rhizome of Atractylodes macrocephala Koidz of Compositae; and (4) frost-down to the beginning of winter, digging, removing stems, leaves and soil, drying or sun-drying, and removing fibrous roots. Bitter and sweet taste, warm nature; it enters spleen and stomach meridians. Has effects in invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, arresting sweating, and preventing miscarriage. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion.

The honey-fried licorice root is prepared by baking licorice root with honey, commonly called as processing, namely, putting honey into a pot to be refined into medium honey, adding raw licorice root with slow fire to be uniformly stir-fried, taking out of the pot for 3-5 min, putting the pot in a baking room or an oven 60-C, taking out the pot until the licorice root is not sticky, and cooling the pot. The Glycyrrhrizae radix is dried root and rhizome of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat or Glycyrrhiza glabra L of Leguminosae. Collected in spring and autumn, removed fibrous root, and dried in the sun. Sweet in flavor and neutral in nature. It enters heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain, and harmonizing the medicines. It is indicated for spleen and stomach deficiency, lassitude and hypodynamia, palpitation and shortness of breath, cough with profuse sputum, spasm and pain of abdomen and limbs, carbuncle and sore, and to relieve toxicity and strong action of drugs.

Radix rehmanniae Preparata is prepared from rhizome of Scrophulariaceae plant rehmanniae or radix rehmanniae by processing, steaming and drying. Sweet and mild in nature and taste, enters liver and kidney meridians, and has effects of replenishing blood and yin, replenishing essence and marrow, and can be used for treating deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, hectic fever due to yin deficiency, night sweat and nocturnal emission, internal heat, diabetes, blood deficiency, sallow complexion, cardiopalmus, palpitation, menoxenia, metrorrhagia, metrostaxis, tinnitus, and premature gray hair.

Radix Angelicae sinensis is root of Angelica sinensis (oliv.) Diels of Umbelliferae. Sweet, pungent and warm in nature and flavor; it enters liver, heart and spleen meridians. Has effects of replenishing blood, regulating menstruation, promoting blood circulation, relieving pain, and loosening bowel to relieve constipation. It can be used for treating blood deficiency syndrome, blood stasis, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency and cold, traumatic injury, superficial infection, pyocutaneous disease, arthralgia due to wind-cold evil, and constipation due to blood deficiency and intestinal dryness.

Radix Paeoniae alba is dried root of Paeonia lactiflora pall of Ranunculaceae. Collected in summer and autumn, cleaned, removed head, tail and fine root, boiled in boiling water, peeled or boiled again, and dried in the sun. Bitter and sour in taste, slightly cold in nature. It enters liver and spleen meridians. Has the functions of nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain and suppressing liver yang. It is commonly used for blood deficiency and chlorosis, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm and pain, headache and vertigo.

Rhizoma Ligustici Chuanxiong is dried rhizome of Umbelliferae plant rhizoma Ligustici Chuanxiong; digging in 5 months, removing silt, drying in the sun, and removing fibrous root. Sliced, unprocessed or stir-baked with wine. Pungent and warm in nature and taste; it enters liver, gallbladder and pericardium meridians. Has the effects of promoting qi circulation, resolving stagnation, dispelling pathogenic wind, eliminating dampness, promoting blood circulation, and relieving pain. It can be used for treating wind-cold headache, vertigo, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, puerperal stagnation, pain, carbuncle, cellulitis, and pyocutaneous disease. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.

The radix Morindae officinalis is dried root of Morinda officinalis of Rubiaceae. Plucked all the year round, cleaned, and then its fibrous root removed, sun-dried to six seven thousand, lightly pounded, and sun-dried. Growing from mountain stream side, mountain sparse forest or cultivating. Sweet and pungent in flavor and slightly warm in nature. It enters kidney and liver meridians. Has the functions of invigorating kidney yang, strengthening physique and expelling wind-damp. It is commonly used for impotence, spermatorrhea, infertility due to cold womb, menoxenia, cold pain in lower abdomen, arthralgia due to wind-dampness, and flaccidity of tendons and bones.

Herba Epimedii is whole herb of Epimedium sagittatum (Maxim.) Maxim or Epimedium brevicornum Maxim of berberidaceae. Produced in Shaanxi, Shanxi, Hubei, Sichuan, Guangxi provinces and other places. Pungent, warm and nontoxic in flavor; herba Epimedii has effects of invigorating kidney, tonifying yang, dispelling pathogenic wind, removing dampness, strengthening tendons and bones, and can be used for treating sexual impotence, spermatorrhea, deficiency cold, infertility, pollakisuria, incontinence of urine, cough and asthma due to kidney deficiency, soreness of waist and knees, rheumatalgia, hemiplegia, and limbs disorder.

Cistanchis herba is succulent stem of Cistanchis herba or Cistanchis herba, etc. of Orobanchaceae. Collected in spring and autumn. However, it is preferable to collect the blood in 3-5 months, and the blood is hollow when it is used. The spring harvest is usually half buried in sandy soil and dried in the sun, and the commercial product is named as sweet herba cistanches, herba cistanches or herba cistanches Deserticolae. In autumn, people are not easy to dry in the sun due to much water, and need to put into a salt lake for 1-3 years, and then take out and dry in the sun, so that the autumn-harvested people are called salt herba cistanches, salty herba cistanches or salty herba cistanches. Sweet and salty in nature and mild in smell. Enter kidney and large intestine meridians. Has effects of invigorating kidney, replenishing vital essence, moistening dryness, and smoothing intestine. Can be used for treating male sexual impotence, female infertility, leukorrhagia, metrorrhagia, lumbago, knee pain, blood depletion, and constipation.

Fructus Schisandrae is mature fruit of Magnoliaceae fructus Schisandrae chinensis or Schisandra sphenanthera. Collected in autumn when the fruit is ripe, dried in the sun. Unprocessed or mixed with vinegar and honey, steamed and dried in the sun. Sour, sweet and warm in nature; it enters lung, heart and kidney meridians. Has effects of astringing, arresting discharge, invigorating qi, promoting fluid production, invigorating kidney, and calming heart. Can be used for treating chronic cough, asthma, spontaneous perspiration, night sweat, spermatorrhea, chronic diarrhea, thirst due to body fluid consumption, palpitation, insomnia, and dreaminess.

Chuangui also known as Rou Gui, Laurus nobilis, Guangui or Xianggui is a generic name of Cinnamomum japonicum, Yin Xiang, Xianggui slim leaf, Rou Gui, etc. of Lauraceae. Each part of the cinnamomum wilsonii contains volatile oil, and has stronger aromatic smell and bioactivity, and the cinnamomum wilsonii is used as a Chinese medicinal material and has the effects of warming channels, dispelling cold, promoting qi and blood circulation, relieving pain, resisting bacteria, diminishing inflammation and the like. The main ingredients include cinnamon, blunted osmanthus, yin-fragrant and Hua nan Gui, and the types are mostly used in regions. The cinnamomum wilsonii is used as spice in ancient western countries, is food spice or cooking seasoning, has the functions of removing fishy smell and enhancing flavor, is used for stewing meat in Chinese food and is one of the ingredients of five spice powder. Chuangui bark has the effects of tonifying kidney, dispelling cold and wind, and treating rheumatism, osteodynia, traumatic injury, abdominal pain, vomiting and diarrhea and the like when used as a medicine.

Radix astragali is root of Astragalus membranaceus bge of Leguminosae. Digging in spring and autumn, removing soil, fibrous root and root head, drying in the sun to six or seven percent, straightening, bundling and drying in the sun. Has sweet and mild nature and taste, enters lung, spleen, liver and kidney meridians, has effects of enhancing organism immunity, protecting liver, promoting urination, resisting aging, resisting stress, lowering blood pressure and broad antibacterial action, and can be used for enhancing immunity.

Ginseng is a perennial herb, is known as the best product of 'all grass king', 'nourishing yin and tonifying life, strengthening body resistance and consolidating constitution' by ancient times, and contains various saponin and polysaccharide components. The succulent root of ginseng is a well-known tonic, is suitable for regulating blood pressure, recovering heart function, neurasthenia and asthenia, and also has expectorant, stomach invigorating, diuretic and exciting effects. Sweet and slightly bitter in taste, warm and mild in nature. It enters spleen, lung and heart meridians. Has effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, tranquilizing, and improving intelligence. Mainly treats asthenia, desire for desertion, cold limbs and a little pulse, spleen deficiency, poor appetite, lung deficiency, cough and asthma, body fluid deficiency, thirst, internal heat, diabetes, deficiency of deficiency caused by chronic diseases, palpitation, insomnia, impotence and cold womb; heart failure, cardiogenic shock. Can be used for treating short breath, dyspnea, palpitation, amnesia, thirst, hyperhidrosis, anorexia, asthenia, acute and chronic diseases, and shock and collapse caused by blood loss. Tonify primordial qi, relieve depletion and promote fluid production, induce tranquilization. It is indicated for deficiency due to overstrain, poor appetite, lassitude, regurgitation, diarrhea, cough, dyspnea, spontaneous sweating, palpitation, amnesia, vertigo, headache, impotence, frequent micturition, diabetes, metrorrhagia, metrostaxis, chronic infantile convulsion, and deficiency of both qi and blood.

The fructus Lycii is mature fruit of Solanaceae plant fructus Lycii or Ningxia fructus Lycii. Sweet in nature and taste and mild in nature. Enter liver and kidney meridians. Has effects of nourishing kidney, moistening lung, nourishing liver, and improving eyesight. Can be used for treating yin deficiency of liver and kidney, soreness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea.

Fructus Amomi is dry mature fruit of Zingiberaceae plant such as YANGCHUNSHA, LVHUSHA or Hainan SHA. Collected in summer and autumn when the fruits are ripe, dried in the sun or at low temperature. Pungent flavor and warm nature. It enters spleen, stomach and kidney meridians. Has effects of eliminating dampness, promoting appetite, warming spleen, relieving diarrhea, regulating qi-flowing, and preventing miscarriage. Can be used for treating damp turbidity obstruction in middle energizer, abdominal distention, inappetence, deficiency-cold of spleen and stomach, emesis, diarrhea, vomiting, and threatened abortion.

The fructus Citri Sarcodactylis is dried fruit of Rutaceae plant fructus Citri Sarcodactylis. Harvesting before or after the fruit turns yellow in autumn, slitting into slices, and drying in the sun or at low temperature. Mainly produced in Guangdong, Fujian, Yunnan and Sichuan provinces. Pungent, bitter and sour in flavor and warm in nature. It enters liver, spleen, stomach and lung meridians. Has the effects of soothing liver, regulating qi, regulating stomach function, relieving pain, eliminating dampness and phlegm. Can be used for treating stagnation of qi of liver and stomach, distending pain in chest and hypochondrium, fullness and distention in stomach, anorexia, emesis, cough, and excessive phlegm.

Fructus Jujubae is mature fruit of Zizyphi fructus of Rhamnaceae. Sweet taste and warm nature; it enters spleen, stomach and heart meridians. Has effects of invigorating spleen, replenishing qi, nourishing blood, and tranquilizing. It is indicated for spleen deficiency syndrome, irritability and insomnia.

Ramulus Cinnamomi is dried twig of Cinnamomum cassia Presl of Lauraceae. Removing leaves, and sun drying or slicing and sun drying. Pungent, sweet and warm in nature; it enters heart, lung and bladder meridians. Has the effects of inducing sweat, expelling pathogenic factors from muscles, warming and activating meridians, supporting yang, and regulating qi. It can be used for treating common cold due to wind-cold, pain due to cold accumulation and blood stagnation, phlegm retention, water retention syndrome, and palpitation.

The colla Corii Asini is the skin of donkey of Equidae, and is prepared by bleaching, soaking, unhairing, and decocting to obtain a block. Sweet and mild in nature and taste; it enters lung, liver and kidney meridians. Has effects in replenishing blood, nourishing yin, moistening lung, and stopping bleeding. Mainly treats blood deficiency syndromes, bleeding syndromes, lung yin deficiency and dry cough, fever and yin impairment, vexation and insomnia, yin deficiency and wind-movement, and limb convulsion.

The invention also provides a preparation method of the pharmaceutical composition for postpartum rehabilitation, which comprises the following steps: weighing the raw materials in proportion, processing after respectively cleaning, grinding and crushing, then putting all the raw materials into a container, adding water for soaking, heating and decocting until the raw materials become thick paste, cooling and cooling. Preferably, the method further comprises soaking in water, decocting under heating, cooling, and filtering to remove residue; wherein the time for heating and decocting is preferably 40-60 min.

Preferably, the particle size of the grinding and crushing is in a range of 50-80 meshes. The step of soaking in water is to add distilled water which is 6-10 times of the total amount of the medicaments by weight, and soak for 30-40 minutes.

The invention also provides application of the composition prepared by the method, and the composition is used for preparing an oral preparation for postpartum rehabilitation. The preparation comprises an oral paste.

The ointment formula is taken from one week after delivery, and the treatment course is 3-6 months; the medicine is taken in the morning and evening, and 6-9 g of the medicine is taken every time.

The pharmaceutical composition for postpartum recovery, the preparation method and the use thereof provided by the present invention are further described below with reference to the following examples.

Examples 1 to 3

In each example, the pharmaceutical composition for postpartum recovery is prepared according to the raw material component proportions shown in the following table 1. All the raw materials respectively accord with the corresponding national standards.

Table 1. ingredient table (in parts by weight) of pharmaceutical composition for postpartum rehabilitation.

The invention also provides a preparation method of the pharmaceutical composition for postpartum recovery of each embodiment and application of the prepared composition of each embodiment.

The method comprises the following steps: weighing the raw materials in proportion, processing after respectively cleaning, grinding and crushing, then putting all the raw materials into a container, adding water for soaking, heating and decocting until the raw materials become thick paste, cooling and cooling.

Preferably, the method further comprises soaking in water, decocting under heating, cooling, and filtering to remove residue; wherein the time for heating and decocting is preferably 40-60 min. The particle size range of grinding and crushing is 50-80 meshes. The step of soaking in water is to add distilled water which is 6-10 times of the total amount of the medicaments by weight, and soak for 30-40 minutes. More preferably, 10 doses of the medicinal composition are decocted to obtain 3 bottles.

The composition can be used for preparing oral preparation for puerperal rehabilitation. The preparation comprises an oral paste. The ointment formula is taken from one week after delivery, and the treatment course is 3-6 months; the medicine is taken in the morning and evening, and 6-9 g of the medicine is taken every time.

The composition prepared by the embodiments of the invention is used for preparing oral preparations, and clinical trials are randomly carried out on thousands of postpartum women, so that the content of patients with obvious effects can reach more than 87%, and the satisfaction can reach more than 94.2%.

According to the pharmaceutical composition for postpartum recovery and the preparation method and the application thereof, provided by the invention, by referring to the six meridians dialectical principle of the Shanghai treatise on the typhoid treatise, after a parturient produces, the baby obtains life and takes away part of yin deficiency, monarch fire and ministerial fire, so that the fire of the Mingmen is reduced, the 'cold image' appears, and symptoms such as cold limbs, spontaneous sweating, chilly, pelvic floor muscle relaxation and urine leakage, involuntary uterus badness and the like appear in clinic; deficiency-cold of shaoyin and weakness of vaporization, so that the earth in taiyin is not transported, the generation of wei-defensive qi, ying-nutrient blood is reduced, the body energy is weakened, phlegm is turbid and transverse, a virtual image appears, and symptoms such as limb weakness, abdominal distension, abnormal stool, obesity and the like appear clinically; the failure of the middle-jiao and earth to transport and the weak qi of ying-wei, the failure of the taiyang to protect the exterior, exterior syndrome, spontaneous sweating, aversion to wind, stagnation of the neck and back, body pain and headache. Therefore, the postpartum rehabilitation is carried out by 'internal and external regulation', and the effects of warming and invigorating spleen and kidney, strengthening and transporting middle-jiao soil, lifting yang and sinking, and consolidating superficial resistance and recovering from old are achieved by mainly starting from the three channels of shaoyin channel, Taiyin channel and Taiyang channel. Aiming at the etiology and pathogenesis of the disease, the invention utilizes the compatibility principle that medicines supplement each other, purposefully combines the medicines according to the organization and structure of monarch, minister, assistant and guide, ensures that the medicines in the prescription and the compatibility thereof are screwed with the pathogenesis of the disease, and ensures that the comprehensive effect after the medicines are combined is highly unified with the established treatment method. The composition is a prescription formed by clinical tests of multiple cases, the functions and the indications of each medicine and the research according to modern Chinese and western medicine pharmacology, has the characteristics of scientific and reasonable formula, simple and easy preparation method and easy popularization, can effectively regulate the postpartum state of women, has good rehabilitation effect, and has no adverse reaction and side effect.

While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.

Claims

1. A pharmaceutical composition for postpartum recovery, the composition comprising:

codonopsis pilosula, poria cocos, bighead atractylodes rhizome, honey-fried licorice root, prepared rehmannia root, Chinese angelica, white paeony root, ligusticum wallichii, morinda officinalis, herba epimedii, cistanche, schisandra chinensis, cinnamomum wilsonii, astragalus mongholicus, ginseng, medlar, fructus amomi, fingered citron, Chinese date, cassia twig and donkey-hide gelatin.

2. The pharmaceutical composition for postpartum recovery of claim 1, wherein the composition comprises, in parts by weight:

25-35 parts of codonopsis pilosula, 12-18 parts of poria cocos, 12-18 parts of bighead atractylodes rhizome, 10-15 parts of honey-fried licorice root, 18-22 parts of prepared rehmannia root, 12-18 parts of Chinese angelica, 12-18 parts of white peony root, 8-12 parts of ligusticum wallichii, 10-15 parts of morinda officinalis, 12-18 parts of epimedium, 10-15 parts of cistanche, 8-12 parts of schisandra chinensis, 4-8 parts of cinnamomum wilsonii, 18-22 parts of astragalus membranaceus, 3-7 parts of ginseng, 12-18 parts of medlar, 4-8 parts of fructus amomi, 8-12 parts of fingered citron, 12-18 parts of Chinese date, 8-12 parts of cassia twig and 8-12 parts of donkey-.

3. The pharmaceutical composition for postpartum recovery of claim 2, wherein the composition comprises, in parts by weight:

30 parts of codonopsis pilosula, 15 parts of poria cocos, 15 parts of bighead atractylodes rhizome, 12 parts of honey-fried licorice root, 20 parts of prepared rehmannia root, 15 parts of Chinese angelica, 15 parts of white paeony root, 10 parts of ligusticum wallichii, 12 parts of morinda officinalis, 15 parts of herba epimedii, 12 parts of cistanche, 10 parts of schisandra chinensis, 6 parts of cinnamomum wilsonii, 20 parts of astragalus mongholicus, 5 parts of ginseng, 15 parts of medlar, 6 parts of fructus amomi, 10 parts of fingered citron, 15 parts of Chinese dates, 10 parts of cassia twig and 10 parts of.

4. A method for preparing a pharmaceutical composition for postpartum recovery as claimed in any one of claims 1 to 3, wherein the method comprises: weighing the raw materials in proportion, processing after respectively cleaning, grinding and crushing, then putting all the raw materials into a container, adding water for soaking, heating and decocting until the raw materials become thick paste, cooling and cooling.

5. The method for preparing a pharmaceutical composition for postpartum recovery as claimed in claim 4, wherein the particle size of the ground and crushed in the method is in the range of 50-80 mesh.

6. The method for preparing the pharmaceutical composition for postpartum recovery as claimed in claim 4, wherein the soaking in water in the method is performed for 30-40 minutes by adding distilled water in an amount 6-10 times the total amount of the drug by weight.

7. Use of a composition prepared by the method of claim 4 for the preparation of an oral formulation for postpartum recovery.

8. Use of a composition according to claim 7, wherein the formulation comprises an internal cream formulation.

9. The composition for use according to claim 8, wherein the cream formulation is administered starting one week after delivery and the treatment period is 3-6 months.

10. The use of the composition according to claim 9, wherein the formulation is administered in the morning and evening, 6-9 grams each time.