CN107715005A - Prevent and treat Chinese medicine of duck infectious serositis and preparation method thereof - Google Patents
Prevent and treat Chinese medicine of duck infectious serositis and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to the Chinese medicine of preventing and treating duck infectious serositis, it is made up of the raw material of following parts by weight：Herba Andrographitis,Radix Isatidis,Honeysuckle,Oriental wormwood,The radix paeoniae rubrathe,Cassia twig,Balloonflower root,Bilobed grewia root stem and leaf,Malt,Felwort,Cape jasmine,Radix bupleuri,It is windproof,Radix glycyrrhizae,The capsule of weeping forsythia,Maidenhair,Giant knotweed,Yncaria stem with hooks,Paper mulberry Fruit,Selaginella tamariscina,Grass-leaved sweetflag,Bush,Sea-buckthorn,The Chinese bulbul,Stringy stonecrop,Water phoenix is celestial,Pennywort,The present invention is according to tcm theory,Scientific compatibility,Remain the combined effect of Chinese medicinal formulae diagnosis and treatment,It is curative for effect according to clinical verification,It is a kind of nuisanceless,The green veterinary drug of no drug residue,It is quick,Good effect,Securely and reliably,Without hazard residue,It is not likely to produce drug resistance,It is without any side effects,With clearing heat and detoxicating,Expelling wind to resolve the exterior,The function of strengthening vital QI to eliminate pathogenic factors,Cure rate is high,More than 93.7% can reach to duck infectious serositis cure rate,Cost price is cheap,Its preparation method is simple,It is adapted to scale industrial production.
Description
Technical field
The invention belongs to biological agent to prepare and poultry disease prevention and control technical field, and in particular to prevents and treats duck infectious serositis
Chinese medicine and preparation method thereof.
Background technology
Duck infectious serositis also known as Pasteurella anatipestipestifer disease, new duck disease or duck septicaemia, are drawn by Pasteurella anatipestipestifer
A kind of chronic or acute septic infectious disease of the infringement duckling risen.It is characterized in that cause duckling cellulose pericarditis, perihepatitis,
Air bag inflammation and arthritis.The disease is widely distributed in all over the world, without obvious seasonal, typically with cold season winter in spring fall ill compared with
It is more, can be by respiratory tract infection, infection rate of falling ill may be up to more than 90%, skin infection and feed and water bone infection, cause dead
Die, weight loss and eliminate, the death rate is higher, and 5~75%, huge economic loss is caused to world's duck culturing industry.The disease is main
Infected duck, turkey, chicken, goose and some wild fowls can also infect.In the case of nature, the duckling of 2~8 week old is susceptible, wherein with 2~
3 week old ducks are most susceptible, can occur throughout the year, are subcooled, overheat and severe feeding environment all easily causes morbidity.1 week
Infection morbidity is not easy in age and more than 8 week old.In duck group is polluted, infection rate is very high, and up to more than 90%, the death rate is 5%
Between~80%.Brooding, house duck population density is excessive, and atmosphere draught-free, ground is moist, and sanitary condition is bad, protein water in feed
Flat too low, vitamin and microelement deficiencies and other stress factors etc. can promote the sick generation and prevalence.
The disease is reported most earlier than 1932 in the U.S. by Hendrickson and Hibert, and is separated to disease from the duck that dies of illness
It is former；Nineteen fifty-five Dougherty has carried out pathological research to this disease, it is found that " scrositis " is critically important pathological characters, therefore order
Entitled duck infectious serositis.Then, Canada, Spain, Singapore, Thailand, Norway, Australia, Japan etc. report in succession
Road has the disease popular, nearly all there is this disease all over the world so far.
The disease mainly infects through respiratory tract or skin wound, and the air being contaminated by bacterial is important route of transmission, through egg
The main reason for transmission is probably long-distance communications.The disease can occur, winter in spring is more throughout the year without obvious seasonality
It is multiple.Incubation period is 1~3 day, sometimes up to 1 week.Morbus acutissimus example is often without any symptom die by visitation of God.The clinic of acute case
Show that spiritedness is depressed, and necking down, somnolence, mouth are dug earth with the snout, and leg is soft, are reluctant to walk about, are slow in action, incoordination, anorexia or not
Think diet.Eye has serosity or mucus sexual secretion, two eye circumferences is enclosed feather adhesion and comes off.Also there are secretion, excrement in nostril
Just it is thin, in green or yellow green, part duckling abdominal distension.There is spasm before dead, shake the head, carry on the back neck and stretch one's legs in opisthotonos, twitch
It is and dead.The course of disease is generally 1~2 day.And the duckling of 4~7 week old, the course of disease was up to more than 1 week, in acute or chronic process, mainly
Spiritual depressed, the poor appetite of performance, limb soft sleeper, it is not former to walk about, often it is in sitting position of dog gesture, and then there is incoordination, it is spastic
Nod or assume an air of complacency, it is preceding face upward after turn over, in supine position, the visible neck having is crooked, turn-takes, and retreats walking, sick duck becomes thin, exhale
Inhale difficult, last exhaustion death.
The change of its characteristic pathological is that have cellulosic inflammatory exudate on serosal surface, with pericardium, liver envelope and air bag
Based on the inflammation of wall.Pericardium is coated to faint yellow or cheesy fibrinous exudate, pericardium it is intracapsular full of yellow floccule and
Faint yellow diffusate.Liver surface covers one layer of canescence or lark cellulosic film.Air bag muddiness thickens, attached on airbag wall
There is fibrinous exudate.Spleen enlargement or enlargement unobvious, surface have cellulosic film, and some case spleens substantially swell
Greatly, in cervinus mottling.Meninx and brain parenchym blood vessel dilatation, extravasated blood.The common Bock joint of chronic cases and gambrel swelling,
Incision is shown in that joint fluid increases.There is cheesy exudate in a small number of fallopian tubals.
Duck infectious serositis has become current duck producer and wants one of epidemic disease, serious threat duck aquaculture
Sound development.According to incompletely statistics, every year because loss caused by duck infectious serositis is up to more than one hundred million members.And due to anti-
Have there are drug resistance problems in a large amount of uses of raw element, many areas, or even to most antibiotics substantially without sensitivity
Property.Therefore, exploitation is a kind of effectively to prevent and treat the traditional Chinese medicine oral liquid of duck infectious serositis, while avoids drug resistance, medicine are residual from asking
Topic has become very urgent problem.
Western medicine antibiotics class treatment duck infectious serositis has certain effect, but is also easy to produce antibody-resistant bacterium and its medicament residue
The problem of problem and drug resistance long-term existence, be not easy to solve, serious threat food-safety problem.Therefore by entering to traditional Chinese medicine
Row rationally screens and prescription, and develop has very important production practices for preventing and treating the Chinese medicine preparation of duck infectious serositis
Meaning.
Because the serotype of Mo Shi bacillus in pest of duck is more, resistant rate is high and extensive, cross resistance is more, and a kind of medicine makes
Substantially reduced or without much effects with its effect after a course for the treatment of.Vaccine, medical treatment effect are still undesirable, therefore find peace
It is complete reliable, turned into the problem of in the urgent need to address during the current disease is treated without hazard residue, the medicine for being not likely to produce drug resistance.
Chinese medicine has overall curative effect high, the advantages that being not likely to produce drug resistance, growth and breeding to cause of diseases such as bacterium, viruses
There is significant inhibitory action, even up to kill the pharmacological effect of cause of disease, and can adjust, promote the immunologic function of body, have
There is non-specific resisting pathogenic microbes.Traditional Chinese veterinary medicine thinks that the disease belongs to " warm disease, acute infantile convulsions " category, clinically with hair
Heat, twitch, coma be main symptom, and sick position is in conscience, based on heat symptom-complex, real example, therefore principle of reatment be " it is clearing heat and detoxicating, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. only
It is frightened, eliminate phlegm for resuscitation ".At present, there is the Chinese medicine of some treatment duck oromeningitis, compared with the Western medicine such as above-mentioned antibiotic, although tool
There is the advantages of cheap, but its therapeutic effect and effective speed are very slow, longer period of time can just make symptom after medication
Disappear, so the problem of still can not thoroughly eliminating medicament residue.
The content of the invention
It is an object of the invention to：For above-mentioned deficiency, the invention provides preventing and treating duck infectious serositis
Chinese medicine and preparation method thereof.The present invention is imitated according to tcm theory, scientific compatibility, the combination for remaining Chinese medicinal formulae diagnosis and treatment
Should, it is curative for effect according to clinical verification, it is a kind of nuisanceless, no drug residue green veterinary drug, quick, good effect, safe and reliable, nothing
Hazard residue, it is not likely to produce drug resistance, is without any side effects, there is clearing heat and detoxicating, expelling wind to resolve the exterior, the function of strengthening vital QI to eliminate pathogenic factors,
Cure rate is high, and more than 93.7% is can reach to duck infectious serositis cure rate, while can strengthen the disease resistance of ill duck,
Cost price is cheap, and its preparation method is simple, is adapted to scale industrial production.
In order to achieve the above object, present invention employs following technical scheme：
A kind of Chinese medicine for preventing and treating duck infectious serositis, is made up of the raw material of following parts by weight：75~95 parts of Herba Andrographitis, Radix Isatidis
75~95 parts, 75~95 parts of honeysuckle, 70~90 parts of oriental wormwood, 70~90 parts of the radix paeoniae rubrathe, 70~90 parts of cassia twig, 70~90 parts of balloonflower root,
65~85 parts of bilobed grewia root stem and leaf, 65~85 parts of malt, 65~85 parts of felwort, 60~80 parts of cape jasmine, 60~80 parts of radix bupleuri, it is windproof 55~
75 parts, 55~75 parts of radix glycyrrhizae, 50~70 parts of the capsule of weeping forsythia, 50~70 parts of maidenhair, 45~65 parts of giant knotweed, 45~65 parts of yncaria stem with hooks, paper mulberry fruit
40~60 parts of son, 40~60 parts of Selaginella tamariscina, 40~60 parts of grass-leaved sweetflag, 35~55 parts of bush, 35~55 parts of sea-buckthorn, the Chinese bulbul 30~50
Part, 30~50 parts of stringy stonecrop, 20~40 parts of water phoenix celestial being, 25~45 parts of pennywort.
Further, the Chinese medicine of described preventing and treating duck infectious serositis, is made up of the raw material of following parts by weight：Herba Andrographitis
80~90 parts, 80~90 parts of Radix Isatidis, 80~90 parts of honeysuckle, 75~85 parts of oriental wormwood, 75~85 parts of the radix paeoniae rubrathe, cassia twig 75~85
Part, 75~85 parts of balloonflower root, 70~80 parts of bilobed grewia root stem and leaf, 70~80 parts of malt, 70~80 parts of felwort, 65~75 parts of cape jasmine, radix bupleuri
65~75 parts, windproof 60~70 parts, 60~70 parts of radix glycyrrhizae, 55~65 parts of the capsule of weeping forsythia, 55~65 parts of maidenhair, 50~60 parts of giant knotweed,
50~60 parts of yncaria stem with hooks, 45~55 parts of Paper mulberry Fruit, 45~55 parts of Selaginella tamariscina, 45~55 parts of grass-leaved sweetflag, 40~50 parts of bush, sea-buckthorn 40~
50 parts, 35~45 parts of the Chinese bulbul, 35~45 parts of stringy stonecrop, 25~35 parts of water phoenix celestial being, 30~40 parts of pennywort.
Further, the Chinese medicine of described preventing and treating duck infectious serositis, is made up of the raw material of following parts by weight：Herba Andrographitis
85 parts, 85 parts of Radix Isatidis, 85 parts of honeysuckle, 80 parts of oriental wormwood, 80 parts of the radix paeoniae rubrathe, 80 parts of cassia twig, 80 parts of balloonflower root, 75 parts of bilobed grewia root stem and leaf, wheat
75 parts of bud, 75 parts of felwort, 70 parts of cape jasmine, 70 parts of radix bupleuri, windproof 65 parts, 65 parts of radix glycyrrhizae, 60 parts of the capsule of weeping forsythia, 60 parts of maidenhair, tiger
55 parts of cane, 55 parts of yncaria stem with hooks, 50 parts of Paper mulberry Fruit, 50 parts of Selaginella tamariscina, 50 parts of grass-leaved sweetflag, 45 parts of bush, 45 parts of sea-buckthorn, 40 parts of the Chinese bulbul,
40 parts of stringy stonecrop, water phoenix celestial 30 parts, 35 parts of pennywort.
Further, the preparation method of the Chinese medicine of described preventing and treating duck infectious serositis, is comprised the steps of：
（1）Weigh in parts by weight oriental wormwood, cassia twig, balloonflower root, bilobed grewia root stem and leaf, malt, radix bupleuri, windproof, radix glycyrrhizae, the capsule of weeping forsythia, maidenhair and
Giant knotweed, 0.5~2cm segment is chopped into, it is 85~89% ethanol solutions to add 6~10 times of concentration of cassia twig weight, soaks 4~8h
6~10h of heating and refluxing extraction afterwards, natural filtration obtain decoction and the dregs of a decoction, and decoction, which is concentrated under reduced pressure, obtains dry cream body, and reclaims second
Alcohol, dry cream body feeding pulverizer are crushed to the mesh of granularity 250~290 and obtain fine powder；
（2）After yncaria stem with hooks, Paper mulberry Fruit, Selaginella tamariscina, grass-leaved sweetflag, bush, sea-buckthorn, the Chinese bulbul, stringy stonecrop, water phoenix celestial being and pennywort are crushed
100~200 mesh sieves are crossed, puts into mixer, is uniformly mixed, are sent into multi-function extractor, addition Chinese bulbul weight 8~
12 times of water, 5~7h is decocted, then through steam pressure be 0.6~1Mpa processing, be filtrated to get filtrate and filter residue；
（3）By Herba Andrographitis, Radix Isatidis, honeysuckle, the radix paeoniae rubrathe, felwort, cape jasmine and step（1）The dregs of a decoction and step（2）Filter
Slag is sent into baking box and toasts 6~10h, is baked to material moisture less than 40%, is sent into super-fine powder mill for another and was ground into
350~450 mesh sieve powder, are well mixed using ultrasonic wave, obtain ultra-micro powder；
（4）By step（1）Fine powder and step（3）Ultra-micro powder be well mixed, add step（2）Filtrate, stir,
It is 1.06 to adjust relative density, then carries out by spray dryer being spray dried to 300~400 targeted fine powders, is put into granulator
In a diameter of 2~4mm particle is made, produce the Chinese medicine.
Further, in step（4）, the compressed air pressure of the spray dryer shower nozzle is 4kg/m2, and hothouse is warm
Gas flow temperature is 105 DEG C.
In summary, the present invention has the positive effect that as a result of such scheme：
（1）The present invention scientific compatibility, remains the combined effect of Chinese medicinal formulae diagnosis and treatment, tested through clinic according to tcm theory
Demonstrate,prove curative for effect, be a kind of nuisanceless, no drug residue green veterinary drug, quick, good effect, it is safe and reliable, without hazard residue, no
Drug resistance, without any side effects and convenient to take, medicine feed after being both mixed with water are also easy to produce, can also be with feed
Medicine feed after mixing；Both it can be used for the prevention of duck oromeningitis, and can be used for the treatment of duck oromeningitis.
（2）The traditional Chinese medicine ingredients that the present invention contains can effectively prevent and treat duck infectious serositis, and duck infectious serositis is cured
Rate can reach more than 93.7%.This prescription has the function that product, spasmolysis of bringing down a fever, detumescence and apocenosis are broken in clearing heat and detoxicating, purging intense heat, keeps away simultaneously
The residue problem of the drug resistance and medicine of chemicals in duck, egg is exempted from.
（3）Among inventive formulation, Herba Andrographitis, Radix Isatidis and honeysuckle are clearing heat and detoxicating common medicine, during three is
The classical collocation of medicine, to treat the conventional medicine of popular breathing problem, it can effectively avoid spasm, sudden death because of caused by high fever
Deng, and quickly bring down a fever, enhancing duck feeding recovers constitution, the treatment to the duck with scrositis from entirety, carry out dialectical opinion
To control, there is clearing heat and detoxicating, expelling wind to resolve the exterior, the function of strengthening vital QI to eliminate pathogenic factors, cure rate is high, uneasy to recur, pure natural, have no toxic side effect,
It is evident in efficacy, drug resistance, drug residue free are not produced, while the disease resistance of ill duck can be strengthened, cost price is cheap, its
Preparation method is simple, is adapted to scale industrial production.
Embodiment
Chinese medicine of duck infectious serositis and preparation method thereof is prevented and treated the present invention with reference to embodiment, is made furtherly
It is bright.
Embodiment 1
A kind of Chinese medicine for preventing and treating duck infectious serositis, is made up of the raw material of following parts by weight：75 parts of Herba Andrographitis, Radix Isatidis 75
Part, 75 parts of honeysuckle, 70 parts of oriental wormwood, 70 parts of the radix paeoniae rubrathe, 70 parts of cassia twig, 70 parts of balloonflower root, 65 parts of bilobed grewia root stem and leaf, 65 parts of malt, felwort
65 parts, 60 parts of cape jasmine, 60 parts of radix bupleuri, windproof 55 parts, 55 parts of radix glycyrrhizae, 50 parts of the capsule of weeping forsythia, 50 parts of maidenhair, 45 parts of giant knotweed, yncaria stem with hooks 45
Part, 40 parts of Paper mulberry Fruit, 40 parts of Selaginella tamariscina, 40 parts of grass-leaved sweetflag, 35 parts of bush, 35 parts of sea-buckthorn, 30 parts of the Chinese bulbul, 30 parts of stringy stonecrop, water
Phoenix celestial being 20 parts, 25 parts of pennywort.
The preparation method of the Chinese medicine of preventing and treating duck infectious serositis described above, is comprised the steps of：
（1）Weigh in parts by weight oriental wormwood, cassia twig, balloonflower root, bilobed grewia root stem and leaf, malt, radix bupleuri, windproof, radix glycyrrhizae, the capsule of weeping forsythia, maidenhair and
Giant knotweed, 0.5cm segment is chopped into, it is 85% ethanol solution to add 6 times of concentration of cassia twig weight, soaks heating and refluxing extraction after 4h
6h, natural filtration obtain decoction and the dregs of a decoction, and decoction, which is concentrated under reduced pressure, obtains dry cream body, and reclaims ethanol, and dry cream body is sent into pulverizer
It is crushed to the mesh of granularity 250 and obtains fine powder；
（2）After yncaria stem with hooks, Paper mulberry Fruit, Selaginella tamariscina, grass-leaved sweetflag, bush, sea-buckthorn, the Chinese bulbul, stringy stonecrop, water phoenix celestial being and pennywort are crushed
100 mesh sieves are crossed, puts into mixer, is uniformly mixed, are sent into multi-function extractor, add the water of 8 times of Chinese bulbul weight,
5h is decocted, then through steam pressure is 0.6Mpa processing, is filtrated to get filtrate and filter residue；
（3）By Herba Andrographitis, Radix Isatidis, honeysuckle, the radix paeoniae rubrathe, felwort, cape jasmine and step（1）The dregs of a decoction and step（2）Filter
Slag is sent into baking box baking 6h, is baked to material moisture less than 40%, is sent into super-fine powder mill for another and was ground into 350 mesh
Powder is sieved, is well mixed using ultrasonic wave, obtains ultra-micro powder；
（4）By step（1）Fine powder and step（3）Ultra-micro powder be well mixed, add step（2）Filtrate, stir,
It is 1.06 to adjust relative density, then carries out by spray dryer being spray dried to 300 targeted fine powders, is put into granulator and is made
A diameter of 2mm particle, produce the Chinese medicine；The compressed air pressure of the spray dryer shower nozzle is 4kg/m2, hothouse
Hot stream temperature is 105 DEG C.
Embodiment 2
A kind of Chinese medicine for preventing and treating duck infectious serositis, is made up of the raw material of following parts by weight：95 parts of Herba Andrographitis, Radix Isatidis 95
Part, 95 parts of honeysuckle, 90 parts of oriental wormwood, 90 parts of the radix paeoniae rubrathe, 90 parts of cassia twig, 90 parts of balloonflower root, 85 parts of bilobed grewia root stem and leaf, 85 parts of malt, felwort
85 parts, 80 parts of cape jasmine, 80 parts of radix bupleuri, windproof 75 parts, 75 parts of radix glycyrrhizae, 70 parts of the capsule of weeping forsythia, 70 parts of maidenhair, 65 parts of giant knotweed, yncaria stem with hooks 65
Part, 60 parts of Paper mulberry Fruit, 60 parts of Selaginella tamariscina, 60 parts of grass-leaved sweetflag, 55 parts of bush, 55 parts of sea-buckthorn, 50 parts of the Chinese bulbul, 50 parts of stringy stonecrop, water
Phoenix celestial being 40 parts, 45 parts of pennywort.
The preparation method of the Chinese medicine of preventing and treating duck infectious serositis described above, is comprised the steps of：
（1）Weigh in parts by weight oriental wormwood, cassia twig, balloonflower root, bilobed grewia root stem and leaf, malt, radix bupleuri, windproof, radix glycyrrhizae, the capsule of weeping forsythia, maidenhair and
Giant knotweed, 2cm segment is chopped into, it is 89% ethanol solution to add 10 times of concentration of cassia twig weight, soaks heating and refluxing extraction after 8h
10h, natural filtration obtain decoction and the dregs of a decoction, and decoction, which is concentrated under reduced pressure, obtains dry cream body, and reclaims ethanol, and dry cream body is sent into pulverizer
It is crushed to the mesh of granularity 290 and obtains fine powder；
（2）After yncaria stem with hooks, Paper mulberry Fruit, Selaginella tamariscina, grass-leaved sweetflag, bush, sea-buckthorn, the Chinese bulbul, stringy stonecrop, water phoenix celestial being and pennywort are crushed
200 mesh sieves are crossed, puts into mixer, is uniformly mixed, are sent into multi-function extractor, add 12 times of Chinese bulbul weight
Water, 7h is decocted, then through steam pressure be 1Mpa processing, be filtrated to get filtrate and filter residue；
（3）By Herba Andrographitis, Radix Isatidis, honeysuckle, the radix paeoniae rubrathe, felwort, cape jasmine and step（1）The dregs of a decoction and step（2）Filter
Slag is sent into baking box baking 10h, is baked to material moisture less than 40%, is sent into super-fine powder mill for another and was ground into 450 mesh
Powder is sieved, is well mixed using ultrasonic wave, obtains ultra-micro powder；
（4）By step（1）Fine powder and step（3）Ultra-micro powder be well mixed, add step（2）Filtrate, stir,
It is 1.06 to adjust relative density, then carries out by spray dryer being spray dried to 400 targeted fine powders, is put into granulator and is made
A diameter of 4mm particle, produce the Chinese medicine；The compressed air pressure of the spray dryer shower nozzle is 4kg/m2, hothouse
Hot stream temperature is 105 DEG C.
Embodiment 3
A kind of Chinese medicine for preventing and treating duck infectious serositis, is made up of the raw material of following parts by weight：80 parts of Herba Andrographitis, Radix Isatidis 80
Part, 80 parts of honeysuckle, 75 parts of oriental wormwood, 75 parts of the radix paeoniae rubrathe, 75 parts of cassia twig, 75 parts of balloonflower root, 70 parts of bilobed grewia root stem and leaf, 70 parts of malt, felwort
70 parts, 65 parts of cape jasmine, 65 parts of radix bupleuri, windproof 60 parts, 60 parts of radix glycyrrhizae, 55 parts of the capsule of weeping forsythia, 55 parts of maidenhair, 50 parts of giant knotweed, yncaria stem with hooks 50
Part, 45 parts of Paper mulberry Fruit, 45 parts of Selaginella tamariscina, 45 parts of grass-leaved sweetflag, 40 parts of bush, 40 parts of sea-buckthorn, 35 parts of the Chinese bulbul, 35 parts of stringy stonecrop, water
Phoenix celestial being 25 parts, 30 parts of pennywort.
The preparation method of the Chinese medicine of preventing and treating duck infectious serositis described above, is comprised the steps of：
（1）Weigh in parts by weight oriental wormwood, cassia twig, balloonflower root, bilobed grewia root stem and leaf, malt, radix bupleuri, windproof, radix glycyrrhizae, the capsule of weeping forsythia, maidenhair and
Giant knotweed, 1cm segment is chopped into, it is 86% ethanol solution to add 7 times of concentration of cassia twig weight, soaks heating and refluxing extraction 7h after 5h,
Natural filtration obtains decoction and the dregs of a decoction, and decoction, which is concentrated under reduced pressure, obtains dry cream body, and reclaims ethanol, and dry cream body is sent into pulverizer and crushed
Fine powder is obtained to the mesh of granularity 260；
（2）After yncaria stem with hooks, Paper mulberry Fruit, Selaginella tamariscina, grass-leaved sweetflag, bush, sea-buckthorn, the Chinese bulbul, stringy stonecrop, water phoenix celestial being and pennywort are crushed
120 mesh sieves are crossed, puts into mixer, is uniformly mixed, are sent into multi-function extractor, add the water of 9 times of Chinese bulbul weight,
5.5h is decocted, then through steam pressure is 0.7Mpa processing, is filtrated to get filtrate and filter residue；
（3）By Herba Andrographitis, Radix Isatidis, honeysuckle, the radix paeoniae rubrathe, felwort, cape jasmine and step（1）The dregs of a decoction and step（2）Filter
Slag is sent into baking box baking 7h, is baked to material moisture less than 40%, is sent into super-fine powder mill for another and was ground into 370 mesh
Powder is sieved, is well mixed using ultrasonic wave, obtains ultra-micro powder；
（4）By step（1）Fine powder and step（3）Ultra-micro powder be well mixed, add step（2）Filtrate, stir,
It is 1.06 to adjust relative density, then carries out by spray dryer being spray dried to 330 targeted fine powders, is put into granulator and is made
A diameter of 2.5mm particle, produce the Chinese medicine；The compressed air pressure of the spray dryer shower nozzle is 4kg/m2, is dried
Room hot stream temperature is 105 DEG C.
Embodiment 4
A kind of Chinese medicine for preventing and treating duck infectious serositis, is made up of the raw material of following parts by weight：90 parts of Herba Andrographitis, Radix Isatidis 90
Part, 90 parts of honeysuckle, 85 parts of oriental wormwood, 85 parts of the radix paeoniae rubrathe, 85 parts of cassia twig, 85 parts of balloonflower root, 80 parts of bilobed grewia root stem and leaf, 80 parts of malt, felwort
80 parts, 75 parts of cape jasmine, 75 parts of radix bupleuri, windproof 70 parts, 70 parts of radix glycyrrhizae, 65 parts of the capsule of weeping forsythia, 55~65 parts of maidenhair, 60 parts of giant knotweed, hook
60 parts of rattan, 55 parts of Paper mulberry Fruit, 55 parts of Selaginella tamariscina, 55 parts of grass-leaved sweetflag, 50 parts of bush, 50 parts of sea-buckthorn, 45 parts of the Chinese bulbul, stringy stonecrop 45
Part, water phoenix celestial 35 parts, 40 parts of pennywort.
The preparation method of the Chinese medicine of preventing and treating duck infectious serositis described above, is comprised the steps of：
（1）Weigh in parts by weight oriental wormwood, cassia twig, balloonflower root, bilobed grewia root stem and leaf, malt, radix bupleuri, windproof, radix glycyrrhizae, the capsule of weeping forsythia, maidenhair and
Giant knotweed, 1.5cm segment is chopped into, it is 88% ethanol solution to add 9 times of concentration of cassia twig weight, soaks heating and refluxing extraction after 7h
9h, natural filtration obtain decoction and the dregs of a decoction, and decoction, which is concentrated under reduced pressure, obtains dry cream body, and reclaims ethanol, and dry cream body is sent into pulverizer
It is crushed to the mesh of granularity 280 and obtains fine powder；
（2）After yncaria stem with hooks, Paper mulberry Fruit, Selaginella tamariscina, grass-leaved sweetflag, bush, sea-buckthorn, the Chinese bulbul, stringy stonecrop, water phoenix celestial being and pennywort are crushed
180 mesh sieves are crossed, puts into mixer, is uniformly mixed, are sent into multi-function extractor, add 11 times of Chinese bulbul weight
Water, 6.5h is decocted, then through steam pressure be 0.9Mpa processing, be filtrated to get filtrate and filter residue；
（3）By Herba Andrographitis, Radix Isatidis, honeysuckle, the radix paeoniae rubrathe, felwort, cape jasmine and step（1）The dregs of a decoction and step（2）Filter
Slag is sent into baking box baking 9h, is baked to material moisture less than 40%, is sent into super-fine powder mill for another and was ground into 430 mesh
Powder is sieved, is well mixed using ultrasonic wave, obtains ultra-micro powder；
（4）By step（1）Fine powder and step（3）Ultra-micro powder be well mixed, add step（2）Filtrate, stir,
It is 1.06 to adjust relative density, then carries out by spray dryer being spray dried to 370 targeted fine powders, is put into granulator and is made
A diameter of 3.5mm particle, produce the Chinese medicine；The compressed air pressure of the spray dryer shower nozzle is 4kg/m2, is dried
Room hot stream temperature is 105 DEG C.
Embodiment 5
A kind of Chinese medicine for preventing and treating duck infectious serositis, is made up of the raw material of following parts by weight：85 parts of Herba Andrographitis, Radix Isatidis 85
Part, 85 parts of honeysuckle, 80 parts of oriental wormwood, 80 parts of the radix paeoniae rubrathe, 80 parts of cassia twig, 80 parts of balloonflower root, 75 parts of bilobed grewia root stem and leaf, 75 parts of malt, felwort
75 parts, 70 parts of cape jasmine, 70 parts of radix bupleuri, windproof 65 parts, 65 parts of radix glycyrrhizae, 60 parts of the capsule of weeping forsythia, 60 parts of maidenhair, 55 parts of giant knotweed, yncaria stem with hooks 55
Part, 50 parts of Paper mulberry Fruit, 50 parts of Selaginella tamariscina, 50 parts of grass-leaved sweetflag, 45 parts of bush, 45 parts of sea-buckthorn, 40 parts of the Chinese bulbul, 40 parts of stringy stonecrop, water
Phoenix celestial being 30 parts, 35 parts of pennywort.
The preparation method of the Chinese medicine of preventing and treating duck infectious serositis described above, is comprised the steps of：
（1）Weigh in parts by weight oriental wormwood, cassia twig, balloonflower root, bilobed grewia root stem and leaf, malt, radix bupleuri, windproof, radix glycyrrhizae, the capsule of weeping forsythia, maidenhair and
Giant knotweed, 1.2cm segment is chopped into, it is 87% ethanol solution to add 8 times of concentration of cassia twig weight, soaks heating and refluxing extraction after 6h
8h, natural filtration obtain decoction and the dregs of a decoction, and decoction, which is concentrated under reduced pressure, obtains dry cream body, and reclaims ethanol, and dry cream body is sent into pulverizer
It is crushed to the mesh of granularity 270 and obtains fine powder；
（2）After yncaria stem with hooks, Paper mulberry Fruit, Selaginella tamariscina, grass-leaved sweetflag, bush, sea-buckthorn, the Chinese bulbul, stringy stonecrop, water phoenix celestial being and pennywort are crushed
150 mesh sieves are crossed, puts into mixer, is uniformly mixed, are sent into multi-function extractor, add 10 times of Chinese bulbul weight
Water, 6h is decocted, then through steam pressure be 0.8Mpa processing, be filtrated to get filtrate and filter residue；
（3）By Herba Andrographitis, Radix Isatidis, honeysuckle, the radix paeoniae rubrathe, felwort, cape jasmine and step（1）The dregs of a decoction and step（2）Filter
Slag is sent into baking box baking 8h, is baked to material moisture less than 40%, is sent into super-fine powder mill for another and was ground into 400 mesh
Powder is sieved, is well mixed using ultrasonic wave, obtains ultra-micro powder；
（4）By step（1）Fine powder and step（3）Ultra-micro powder be well mixed, add step（2）Filtrate, stir,
It is 1.06 to adjust relative density, then carries out by spray dryer being spray dried to 350 targeted fine powders, is put into granulator and is made
A diameter of 3mm particle, produce the Chinese medicine；The compressed air pressure of the spray dryer shower nozzle is 4kg/m2, hothouse
Hot stream temperature is 105 DEG C.
In summary, the present invention is imitated according to tcm theory, scientific compatibility, the combination for remaining Chinese medicinal formulae diagnosis and treatment
Should, it is curative for effect according to clinical verification, it is a kind of nuisanceless, no drug residue green veterinary drug, quick, good effect, safe and reliable, nothing
Hazard residue, it is not likely to produce drug resistance, is without any side effects, and convenient to take, medicine feed after being both mixed with water,
Medicine feed after being mixed with feed；Both it can be used for the prevention of duck oromeningitis, and can be used for the treatment of duck oromeningitis.The present invention
The traditional Chinese medicine ingredients contained can effectively prevent and treat duck infectious serositis, duck infectious serositis cure rate can reach 93.7% with
On.This prescription has the function that product, spasmolysis of bringing down a fever, detumescence and apocenosis are broken in clearing heat and detoxicating, purging intense heat, while avoids the resistance to of chemicals
The residue problem of the property of medicine and medicine in duck, egg.Among inventive formulation, Herba Andrographitis, Radix Isatidis and honeysuckle are heat-clearing
The common medicine of removing toxic substances, three are the classical collocation of Chinese medicine, to treat the conventional medicine of popular breathing problem, can effectively be avoided because of height
Spasm, sudden death etc. caused by heat, and quickly bring down a fever, enhancing duck feeding, recover constitution, the treatment to the duck with scrositis from
Entirety is set out, carries out diagnosis and treatment, has clearing heat and detoxicating, expelling wind to resolve the exterior, and the function of strengthening vital QI to eliminate pathogenic factors, cure rate is high, uneasy to recur,
It is pure natural, have no toxic side effect, it is evident in efficacy, do not produce drug resistance, drug residue free, while can strengthen ill duck disease resistance
Power, cost price is cheap, and its preparation method is simple, is adapted to scale industrial production.
The preferred embodiment of invention is the foregoing is only, is not intended to limit the invention, all spirit in the present invention
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (5)
1. a kind of Chinese medicine for preventing and treating duck infectious serositis, it is characterised in that be made up of the raw material of following parts by weight：Herba Andrographitis 75
~95 parts, 75~95 parts of Radix Isatidis, 75~95 parts of honeysuckle, 70~90 parts of oriental wormwood, 70~90 parts of the radix paeoniae rubrathe, 70~90 parts of cassia twig,
70~90 parts of balloonflower root, 65~85 parts of bilobed grewia root stem and leaf, 65~85 parts of malt, 65~85 parts of felwort, 60~80 parts of cape jasmine, radix bupleuri 60~
80 parts, windproof 55~75 parts, 55~75 parts of radix glycyrrhizae, 50~70 parts of the capsule of weeping forsythia, 50~70 parts of maidenhair, 45~65 parts of giant knotweed, yncaria stem with hooks
45~65 parts, 40~60 parts of Paper mulberry Fruit, 40~60 parts of Selaginella tamariscina, 40~60 parts of grass-leaved sweetflag, 35~55 parts of bush, sea-buckthorn 35~55
Part, 30~50 parts of the Chinese bulbul, 30~50 parts of stringy stonecrop, 20~40 parts of water phoenix celestial being, 25~45 parts of pennywort.
2. the Chinese medicine of preventing and treating duck infectious serositis according to claim 1, it is characterised in that by the original of following parts by weight
Material is made：80~90 parts of Herba Andrographitis, 80~90 parts of Radix Isatidis, 80~90 parts of honeysuckle, 75~85 parts of oriental wormwood, the radix paeoniae rubrathe 75~85
Part, 75~85 parts of cassia twig, 75~85 parts of balloonflower root, 70~80 parts of bilobed grewia root stem and leaf, 70~80 parts of malt, 70~80 parts of felwort, cape jasmine
65~75 parts, 65~75 parts of radix bupleuri, windproof 60~70 parts, 60~70 parts of radix glycyrrhizae, 55~65 parts of the capsule of weeping forsythia, 55~65 parts of maidenhair,
50~60 parts of giant knotweed, 50~60 parts of yncaria stem with hooks, 45~55 parts of Paper mulberry Fruit, 45~55 parts of Selaginella tamariscina, 45~55 parts of grass-leaved sweetflag, bush 40~
50 parts, 40~50 parts of sea-buckthorn, 35~45 parts of the Chinese bulbul, 35~45 parts of stringy stonecrop, 25~35 parts of water phoenix celestial being, pennywort 30~40
Part.
3. the Chinese medicine of preventing and treating duck infectious serositis according to claim 1, it is characterised in that by the original of following parts by weight
Material is made：85 parts of Herba Andrographitis, 85 parts of Radix Isatidis, 85 parts of honeysuckle, 80 parts of oriental wormwood, 80 parts of the radix paeoniae rubrathe, 80 parts of cassia twig, 80 parts of balloonflower root,
75 parts of bilobed grewia root stem and leaf, 75 parts of malt, 75 parts of felwort, 70 parts of cape jasmine, 70 parts of radix bupleuri, windproof 65 parts, 65 parts of radix glycyrrhizae, 60 parts of the capsule of weeping forsythia,
60 parts of maidenhair, 55 parts of giant knotweed, 55 parts of yncaria stem with hooks, 50 parts of Paper mulberry Fruit, 50 parts of Selaginella tamariscina, 50 parts of grass-leaved sweetflag, 45 parts of bush, sea-buckthorn 45
Part, 40 parts of the Chinese bulbul, 40 parts of stringy stonecrop, water phoenix celestial 30 parts, 35 parts of pennywort.
4. the preparation method of the Chinese medicine of the preventing and treating duck infectious serositis according to any one of claims 1 to 3, its feature exist
In comprising the steps of：
（1）Weigh in parts by weight oriental wormwood, cassia twig, balloonflower root, bilobed grewia root stem and leaf, malt, radix bupleuri, windproof, radix glycyrrhizae, the capsule of weeping forsythia, maidenhair and
Giant knotweed, 0.5~2cm segment is chopped into, it is 85~89% ethanol solutions to add 6~10 times of concentration of cassia twig weight, soaks 4~8h
6~10h of heating and refluxing extraction afterwards, natural filtration obtain decoction and the dregs of a decoction, and decoction, which is concentrated under reduced pressure, obtains dry cream body, and reclaims second
Alcohol, dry cream body feeding pulverizer are crushed to the mesh of granularity 250~290 and obtain fine powder；
（2）After yncaria stem with hooks, Paper mulberry Fruit, Selaginella tamariscina, grass-leaved sweetflag, bush, sea-buckthorn, the Chinese bulbul, stringy stonecrop, water phoenix celestial being and pennywort are crushed
100~200 mesh sieves are crossed, puts into mixer, is uniformly mixed, are sent into multi-function extractor, addition Chinese bulbul weight 8~
12 times of water, 5~7h is decocted, then through steam pressure be 0.6~1Mpa processing, be filtrated to get filtrate and filter residue；
（3）By Herba Andrographitis, Radix Isatidis, honeysuckle, the radix paeoniae rubrathe, felwort, cape jasmine and step（1）The dregs of a decoction and step（2）Filter
Slag is sent into baking box and toasts 6~10h, is baked to material moisture less than 40%, is sent into super-fine powder mill for another and was ground into
350~450 mesh sieve powder, are well mixed using ultrasonic wave, obtain ultra-micro powder；
（4）By step（1）Fine powder and step（3）Ultra-micro powder be well mixed, add step（2）Filtrate, stir,
It is 1.06 to adjust relative density, then carries out by spray dryer being spray dried to 300~400 targeted fine powders, is put into granulator
In a diameter of 2~4mm particle is made, produce the Chinese medicine.
5. the preparation method of the Chinese medicine of preventing and treating duck infectious serositis according to claim 4, it is characterised in that：In step
（4）, the compressed air pressure of the spray dryer shower nozzle is 4kg/m2, and hothouse hot stream temperature is 105 DEG C.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434262A (en) * | 2018-06-30 | 2018-08-24 | 信阳农林学院 | A kind of Chinese medicine composition of prevention and treatment Riemerella anatipestifer disease |
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2017
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434262A (en) * | 2018-06-30 | 2018-08-24 | 信阳农林学院 | A kind of Chinese medicine composition of prevention and treatment Riemerella anatipestifer disease |
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