CN103893424B - A kind of traditional Chinese medicine oral liquid for preventing and treating high-quality chicken cyanomycosis and preparation method thereof - Google Patents
A kind of traditional Chinese medicine oral liquid for preventing and treating high-quality chicken cyanomycosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of traditional Chinese medicine oral liquid for preventing and treating high-quality chicken cyanomycosis and preparation method thereof.The present invention be 15 parts of catechu, 15 parts of Japanese Cayratia Herb, water body are spent 12 parts, 12 parts of radix pseudostellariae, 10 parts of caulis trachelospermi, 10 parts of Oroxylum indicum, 10 parts of eupatorium, 6 parts of 10 parts of the sophora bud and Radix Glycyrrhizae (counting by weight) crushed with pulverizing mill respectively, cross 60 mesh sieves, then it is mixed, soaked with ethanol, the traditional Chinese medicine oral liquid of preventing and treating high-quality chicken cyanomycosis is obtained.Preparation method of the invention is easy, convenient drug administration, it is thus also avoided that easily produces drug resistance, the shortcoming of residual using chemical classes medicine, improves powder spice effect absorption difference and the big problem of usage amount, can reach the purpose of rapid-onset.
Description
Technical field
The present invention relates to field of traditional Chinese veterinary, more particularly to a kind of traditional Chinese medicine oral liquid for preventing and treating high-quality chicken cyanomycosis
And preparation method thereof.
Background technology
Pseudomonas aeruginosa is 1882 first by a kind of GersardShi from the isolated conditionity pathogenic bacteria of wound fester, energy
Cause people and zoogenetic infection to be fallen ill, such as the miscarriage of scale fox farm bitch, the apostematosa pneumonia of flock of sheep, chick septicemia with
And charrin's disease francolin, dove and people etc..
Quality broiler chicken is the big characteristic of China broiler breeding industry one, and from local varieties, the consumption for being adapted to local resident will
Ask, mainly have Huang Yu and numb plumage point, also some areas need the chicken of jute plumage, and part is mainly yellow pin, white pin and green grass or young crops
Pin point, skin color have yellow, white and black point, South China need short-tail, short-foot, body reunion chicken, and
The Yangtze river basin needs long-tail, the tall and thin individuality of body body.
With the development of aquaculture, Pseudomonas aeruginosa to the brooding of high-quality chicken, be bred as bringing and have a strong impact on, cause vast cultivation
Family chicken mortality, meanwhile, the pseudomonal toxin of generation can also cause food poisoning.
Chicken is mass-sended raw Pseudomonas aeruginosa and shows depressed spirit, poor appetite first after being ill, is afraid of cold pad--batch；There is chick to occur in succession
It is dead；Dying chick is trembled, falls down to the ground, dead in a few minutes；Dead chick beak point and claw cyanosis；There is chick to enclose humidity near the eyes,
Cornea or camera oculi anterior are muddy, and there is foam sample secretion at canthus, and the nervous symptoms such as some appearance are trembled, opisthotonos are cold and poly-
Heap；Belly expands, and finger pressure is soft, has difficulty in breathing (belly is agitated), and chicken group occurs white or faint yellow or even green in various degree
Watery diarrhea, perianal pollution excrement, exhaustion is rapid dead；Thorax abdomen is subcutaneous different degrees of oedema, in light green, sternly
Severe one can be extended down to two inboard legs, suffers from joint that chicken has or leg occurs different degrees of swelling and causes to walk lamely.
Can find that diseased chicken neck, umbilical region are subcutaneous in the infiltration of yellow green gel-shaped by dissecting, muscle has blutpunkte or bleeding
Spot.Internal organs congested, bleeding in various degree.Liver is crisp and enlargement, in khaki, there is light lark dot necrosis region.Gall-bladder
It is full.Kidney enlargement, surface is dispersed in bleeding dot.Lungs are congested, and what is had sees blutpunkte, lobulus pulmonis inflammatory lesion, in purplish red
Color or marble sample change.The fatty bleeding of heart hat, and there is gel-shaped to infiltrate, intracardiac, adventitia has bleeding spot.Glandular stomach mucous membrane takes off
Fall, muscular stomach mucous membrane has blood spots, it is easy to peel off, intestinal mucosa is congested, bleeding is serious.Splenomegaly, there is bleeding dot.Air bag muddiness,
Thicken.
The sick prevention and controls are mainly reinforcement feeding and management, do disinfecting work well；It is original application gentamicin, many
Colistin, carbenicillin and sulphadiazine treat this disease effectively, but produce drug resistance to most antibacterials at present,
It is substantially invalid using antibacterials, while easily causing raiser carries out operating difficulties during intramuscular injection, can also cause antibiotic
Harm human health is remained in chicken；Antibacterials can not eliminate the endotoxin of Pseudomonas aeruginosa, with can cause chicken after antimicrobial
Endotoxicosis.
Chinese herbal medicine belongs to natural drug, containing substantial amounts of active skull cap components, such as polysaccharide, tannin, alkaloid, glucoside,
Animal leucocyte phagocytic activity can be strengthened, body non-specific immune function is improved, strengthen premunition and ability to resist stress,
Expelling parasites and food tagnancy, promotes growth of animal, and compared with Western medicine, Chinese herbal medicine has unique advantage, is such as prepared by science, will be to preventing and treating
Poultry diease plays great role.The plurality of Chinese such as the root of large-flowered skullcap, cape jasmine, the coptis, the root of herbaceous peony, myrobalan and Chinese lobelia all have to various harmful bacterias
There are anti-microbial effect, anti-stress effect and immunoregulation effect.But traditional Chinese medicine is main based on powder application, and powder
Spice is bothered, and Chinese medicine is difficult to absorb in chicken body, and the slow, waste that works is big；The program of raiser's decocting herb is also comparatively laborious.
The content of the invention
The technical problems to be solved by the invention are directed to prior art present in preventing and treating high-quality chicken cyanomycosis
It is not enough, there is provided a kind of traditional Chinese medicine oral liquid for preventing and treating high-quality chicken cyanomycosis and preparation method thereof.
Technical scheme is as follows：
A kind of preparation method of the traditional Chinese medicine oral liquid for preventing and treating high-quality chicken cyanomycosis, its step is as follows：
(1) by catechu, Japanese Cayratia Herb, water body flower, radix pseudostellariae, caulis trachelospermi, Oroxylum indicum, eupatorium, the sophora bud and Radix Glycyrrhizae respectively with micro-
Powder machine is crushed, and crosses 60 mesh sieves；
(2) medicinal material after sieving in (1) is mixed, wherein, count by weight, 15 parts of catechu, 15 parts of Japanese Cayratia Herb, water body
Spend 12 parts, 12 parts of radix pseudostellariae, 10 parts of caulis trachelospermi, 10 parts of Oroxylum indicum, 10 parts of eupatorium, 10 parts of the sophora bud, 6 parts of Radix Glycyrrhizae；With 10 times of medicinal materials
70% ethanol of quality soaks 1.5 hours, ultrasonic echography 45 minutes, filtering, then adds 8 times of 70% ethanol immersions of quality of medicinal material
1 hour, ultrasonic echography 25 minutes, filtering merged filtrate twice；
(3) by the filtrate recycling ethanol merged in (2) to dissolving and being diluted to 100% aqueous solution without alcohol taste, plus pure water, i.e.,
Based on raw medicinal herbs, 100mL water Chinese medicines containing 100g；It is subsequently adding the activated carbon of solution quality 0.1% and telling for solution quality 0.1%
Temperature -80 (Tween-80 is hydrotropy effect), filters, with mass percentage concentration for 10% sodium hydroxide solution is adjusted after boiling 10 minutes
PH to 7.5, using flowing steam sterilization, sterilizes 40 minutes at 105 DEG C, obtains final product content of dispersion in 1g/mL (in terms of crude drug)
Medicine oral liquid.
The traditional Chinese medicine oral liquid of the obtained preventing and treating high-quality chicken cyanomycosis of described preparation method.
Basis of the invention is that Chinese veterinarian and chicken cyanomycosis " six external factors which cause diseases is dialectical " are theoretical.Chicken cyanomycosis is wet
Disease, is that chicken group's ambient humidity is excessive, and excessive water is wet to cause the decay of spleen function；Spleen sun is stranded, more powerless transporting water
Wet, long heat of then changing forms damp and hot heresy, and the spleen transportation capabilities imbalance for causing is formed.Principle of reatment preferably use it is clearing heat and detoxicating,
Based on dampness-eliminating and dysentery-stopping, and strengthening the spleen and replenishing qi, appetizing class medicine are suitably equipped with, in the hope of while germ is killed in suppression, adjustment and recovery are sick
The gastrointestinal function of chicken.
The present invention have replenish qi to invigorate the spleen with stomach, hepatic cholagogic, clearing lung and eliminating phlegm, it is clearing heat and detoxicating, by the stasis of blood hemostasis, gut purge antidiarrheal it
Effect, can effectively prevent and treat the disease that high-quality chicken goose Pseudomonas aeruginosa causes, meanwhile, preparation method of the invention is easy, convenient drug administration,
Also avoid and easily produce drug resistance, the shortcoming of residual using chemical classes medicine, improve powder spice effect absorption difference and make
The big problem of consumption, can reach the purpose of rapid-onset.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1
Take catechu 150g, Japanese Cayratia Herb 150g, water body flower 120g, radix pseudostellariae 120g, caulis trachelospermi 100g, Oroxylum indicum 100g, pendant
Blue 100g, sophora bud 100g and Radix Glycyrrhizae 60g, are crushed with pulverizing mill, after crossing 60 mesh sieves, mixing；Then with 10 times of quality of medicinal materials
70% ethanol soak 1.5 hours, ultrasonic echography 45 minutes, filtering, then add the 70% ethanol immersion 1 of 8 times of quality of medicinal materials small
When, ultrasonic echography 25 minutes, filtering merges filtrate twice, reclaims ethanol and extremely dissolves and be diluted to without alcohol taste, plus pure water
100% aqueous solution (based on raw medicinal herbs, i.e. 100mL water Chinese medicine containing 100g), plus the activated carbon of solution quality 0.1% boils 10 minutes
(and adding the Tween-80 hydrotropy of solution quality 0.1%) is filtered afterwards, is that 10% sodium hydroxide solution adjusts PH with mass percentage concentration
Value, using flowing steam sterilization, sterilizes 40 minutes to 7.5 at 105 DEG C, stirs evenly, and sterilizes, and the filling 1000mL that obtains final product is containing 1g/mL
The traditional Chinese medicine oral liquid of the preventing and treating high-quality chicken cyanomycosis of (in terms of crude drug).
The traditional Chinese medicine oral liquid of obtained preventing and treating high-quality chicken cyanomycosis is the supernatant liquid of brownish red, and being long placed in can have micro
Precipitation, jog is fugitive；Taste is sweet, slight bitter.Quality requirement be without becoming sour, foreign odor or other denaturalization phenomenons, according to《Chinese people's republicanism
State's veterinary drug allusion quotation》2010 editions check that it is 5.0~7.0 to meet regulation pH value, and relative density is not less than 1.02.
Embodiment 2
The traditional Chinese medicine oral liquid of the preventing and treating high-quality chicken cyanomycosis prepared to embodiment 1 uses cylinder-plate method and micro meat soup method
Carry out extracorporeal bacteria inhibitor test.
1) drug sensitivity testing in vitro uses cylinder-plate method：Pseudomonas aeruginosa liquid is applied on maconkey agar culture medium, Ran Hou
Media surface places stainless steel tube, with the careful preventing and treating high-quality chicken green pus bar prepared toward dropwise addition 1mL embodiments 1 in steel pipe of dropper
The traditional Chinese medicine oral liquid of bacterium disease, it is the berberine solution of 10mg/L that drug control hole is added dropwise 1mL contents, and negative control group adds 1mL
Physiological saline, is then put into 18-24 hours observation result of 37 DEG C of constant incubator cultures.And determine inhibition zone with slide measure
Diameter, surveys 3 times repeatedly, averages；Test result is as shown in table 1.
2) micro meat soup method：Minimal inhibitory concentration is measured with micro meat soup method, it is first that the obtained preventing and treating of embodiment 1 is excellent
The traditional Chinese medicine oral liquid liquid doubling dilution of matter chicken cyanomycosis aseptically, is used to 1000mg/mL-1.9mg/mL
96 micro reaction plates of ethane via epoxyethane sterilizing, often arrange and add 100 by the order of high concentration to low concentration by the 1st hole to the 10th hole
The liquid that μ L have diluted；11st hole is growth control, is not added with medicine；12nd hole is negative control hole, only adds physiological saline.Adjusting
Good Pseudomonas aeruginosa inoculation liquid concentration is 6 × 10-6The micro- of 100 μ L Pseudomonas aeruginosas inoculation liquids addition 1-11 is taken after CFU/mL after 15min
In hole, this will make the medicine and bacterium solution (2 times of final concentrations) of each gradient respectively by 1：1 is diluted to final concentration.Through 37 DEG C of culture 24h
After observe result, result of the test is shown in Table 2.
The drug sensitive experiment result of table 1
| Medicine | Drug concentration | Antibacterial circle diameter (mm) | Susceptibility |
| Blank | 0 | <10 | - |
| Berberine | 10mg/L | 18.5±0.2 | ++ |
| The traditional Chinese medicine oral liquid of embodiment 1 | 1g/mL | 20.5±0.1 | ++ |
Note：+ represent sensitive, ++ it is quick in expression ,-represent that resistance is insensitive.
The traditional Chinese medicine oral liquid liquid minimum bacteriostatic experiment result of the preventing and treating high-quality chicken cyanomycosis of the embodiment 1 of table 2
Fungistatic effect criterion is pressed《Pharmacology of Chinese materia medica》Standard is：Antibacterial circle diameter<10mm is resistance (-).10mm
~15mm is medium sensitivity (+), and more than 15mm is extremely sensitive (++).Preventing and treating high-quality chicken green pus bar is measured by drug sensitivity testing in vitro
The traditional Chinese medicine oral liquid of bacterium disease is 20.5mm to the antibacterial circle diameter of fowl Pseudomonas aeruginosa, is Gao Min.Micro meat soup method is determined is prevented
The traditional Chinese medicine oral liquid for controlling high-quality chicken cyanomycosis is 62.5mg/mL to the minimal inhibitory concentration (MIC) of Pseudomonas aeruginosa.
Embodiment 3
1) artificial challenge's therapeutic test：Choose 600 healthy high-quality chick and be divided into blank group, infection control group, embodiment 1
Traditional Chinese medicine oral liquid prevention group, the traditional Chinese medicine oral liquid treatment group of embodiment 1, drug control group, every group 100, every in addition to blank group
Chicken is respectively by per 100g body weight chest muscle injection chicken Pseudomonas aeruginosa 6 × 10-6CFU/mL bacterium solution 0.25mL, containing about 1.5 hundred million bacterium.Implement
The traditional Chinese medicine oral liquid prevention group of example 1 before contamination 5 days in advance to 1 traditional Chinese medicine oral liquid of embodiment 0.2mL/ days.Before inoculation and connect
The clinical symptoms of chicken are observed after kind, cut open inspection is carried out to dead chicken, taken liver, spleen and the heart and make bacteria distribution culture and identification, to determine to be
It is no successfully to induce an illness.Infection control group, the traditional Chinese medicine oral liquid prevention group of embodiment 1, the traditional Chinese medicine oral liquid therapeutic test of embodiment 1
After group, drug control group chicken attack malicious 7h, lassitude, dirty and messy, inverse vertical by hair is shown as, flocked together, necking down, wing are sagging, row is yellow
White loose stool, drink, anorexia.Cut open inspection is died of illness chicken, observes viscera, is mainly shown as perihepatitis and pericarditis, hepatomegaly, is filled
There is fibrous exudate on blood, major Liver surface, and air bag is thickened, muddiness, and Glisson's capsule is thickened and has blutpunkte or bleeding band, the heart
Coating is thickened, and small intestinal mucosa has blutpunkte.A large amount of typical Pseudomonas aeruginosas are isolated from liver, spleen and heart, is shown into
Work(induces an illness.
Every chicken daily oral normal saline 0.2mL/ is given in malicious postoperative infection control group is attacked days；The traditional Chinese medicine mouth of embodiment 1
Every chicken of Fu Ye treatment groups oral 1 traditional Chinese medicine oral liquid of embodiment 0.4mL/ days daily；Every chicken of drug control group is oral daily
Concentration is berberine 0.4mL/ days of 10mg/L；The each group morning concentrates administration, and continuous use 5d stops observation post administration 5d.Medication
Period observes the clinical symptom situation of each group chicken, the dead chicken number of record daily.
2) result of the test：Blank group is all survived；The infection control group death rate 55%；The traditional Chinese medicine oral liquid of embodiment 1 is prevented
The chick death rate 5% of group, efficient 95%；The chicken that broods of the traditional Chinese medicine oral liquid treatment group of embodiment 1, after treating 3 days, the state of an illness is
Control, the death rate 8%, efficient 92%, and drug control group cure rate is quite, the results are shown in Table 3.
The artificial challenge's therapeutic test of table 3
| Group | Number of elements | Death toll | Survival number | Efficient % | Death rate % |
| Blank group | 100 | 0 | 100 | 100 | 0 |
| Infection control group | 100 | 45 | 55 | 55 | 45 |
| The traditional Chinese medicine oral liquid prevention group of embodiment 1 | 100 | 5 | 95 | 95 | 5 |
| The traditional Chinese medicine oral liquid treatment group of embodiment 1 | 100 | 8 | 92 | 92 | 8 |
| Drug control group | 100 | 7 | 93 | 93 | 7 |
Embodiment 4
The age in days of the 3000 plumage 7 green grass or young crops pin fiber crops high-quality chicken performance lassitude that the raiser of Sichuan Province's Deyang City one supports, appetite subtracts
Move back or even useless exhausted.Different degrees of diarrhea, draws watery stools, day mortality at 50 or so, once used Ciprofloxacin, strepto- successively
The medicines such as element, effect on driving birds is not good.
1) disease and anatomy are faced
Chicken lassitude, drop-head is closed one's eyes, astasia, incidence swelling, and appetite is useless exhausted；A small number of chicken expiratory dyspnea, eyelid
Swelling, belly expands, and shows green abdomen, gradually occurs dead.Find that incidence and subcutaneous abdomen have faint yellow gel-shaped through dissecting
Exudate, integumentary musculature has blutpunkte；Enteron aisle is dispersed in petechial hemorrhage；Hydropericardium, the external membrane of heart has petechial hemorrhage, and pericardium is mixed
It is turbid；Liver enlargement, matter are crisp, khaki；Spleen enlargement, bleeding；Tracheal strips have pink bag foam-like liquid；Pulmonary hemorrhage, there is fibre
The plain exudate of dimension；Yolk malabsorption is in yellow green；Kidney enlargement.
2) bacteria distribution identification：The visible Gram-negative median size of microscopy, more elongated bacillus.Sent out on plain agar
Educate good, grow smooth, circular surface, moistening, flat bacterium colony, agar is changed into blue-green；On blood agar plate, bacterium colony
In β haemolysis；Colourless, translucent, smooth circular bacterium colony is grown on maconkey agar：Meat soup culture 48h is changed into blue-green, has
Mycoderm.The bacterium colony smear staining microscopy of picking culture, is Gram-negative, median size, more elongated bacillus.The bacterium is fermented
Glucose and xylose, oxidase test is positive.
3) animal Orthogonal Rotational Regressive Tests：Take separated bacterium grown in broth bouillon dilution bacterial concentration be
10x104CFU/mL, gives healthy chick hypodermic injection 0.1mL respectively, and chick is all dead after 24h.
4) laboratory diagnosis
According to the sick incidence, clinical symptoms, cut open inspection lesion and laboratory inspection, chick Pseudomonas aeruginosa is diagnosed as
Disease.
5) treated using the present invention program：Chick environment is carried out disinfection, and eliminates small and weak chicken, then use the present invention
Traditional Chinese medicine oral liquid prepared by middle embodiment 1 is treated, the traditional Chinese medicine oral liquid and water 1 prepared using embodiments of the invention 1:8
Full group's drinking-water is carried out after mixing；Drip is carried out to serious chicken simultaneously, every traditional Chinese medicine oral liquid of the embodiment of chicken 0.4mL 1 is used in conjunction
5 days.Chicken group is dead after 4 days is reduced, and chicken appetite of mining massively starts to recover, and mental restoration is normal, then according still further to implementation of the invention
Traditional Chinese medicine oral liquid prepared by example 1 and water 1:Full group is carried out after 10 mixing to drink water 5 days, the disease does not occur to 30 days de- temperature of chicken group,
Obtain promising result, cure rate 86.5%.
Meanwhile, also to clinically to send out Pseudomonas aeruginosa other different days section 25 batches of high-quality chickens of various kinds, altogether
Count 10.46 ten thousand to be treated, cure rate is 86.2%.
Traditional Chinese medicine oral liquid of the invention advises consumption：Young chicken, 0.2-0.6mL/ is only；Middle chicken 0.4-0.8mL/ is only；Adult Chicken
0.8-1.2mL/ is only.Mixed drink, prevention is converted per 1L chickens drinking-water plus the traditional Chinese medicine oral liquid 1mL of embodiment 1 is used in conjunction 3-5 days, during treatment, per 1L
Chicken drinking-water is converted plus traditional Chinese medicine oral liquid 2mL is used in conjunction 5-7 days or follows the doctor's advice.It should be appreciated that coming to those of ordinary skill in the art
Say, can according to the above description be improved or converted, and all these modifications and variations should all belong to right appended by the present invention
It is required that protection domain.
Claims (2)
1. it is a kind of prevent and treat high-quality chicken cyanomycosis traditional Chinese medicine oral liquid preparation method, it is characterized in that, its step is as follows：
(1) catechu, Japanese Cayratia Herb, water body flower, radix pseudostellariae, caulis trachelospermi, Oroxylum indicum, eupatorium, the sophora bud and Radix Glycyrrhizae are used into pulverizing mill respectively
Crushed, crossed 60 mesh sieves；
(2) medicinal material after sieving in (1) is mixed, wherein, to count by weight, 15 parts of catechu, 15 parts of Japanese Cayratia Herb, water body spend 12
Part, 12 parts of radix pseudostellariae, 10 parts of caulis trachelospermi, 10 parts of Oroxylum indicum, 10 parts of eupatorium, 10 parts of the sophora bud, 6 parts of Radix Glycyrrhizae；With 10 times of quality of medicinal materials
70% ethanol soak 1.5 hours, ultrasonic echography 45 minutes, filtering, then add the 70% ethanol immersion 1 of 8 times of quality of medicinal materials small
When, ultrasonic echography 25 minutes, filtering merges filtrate twice；
(3) by the filtrate recycling ethanol merged in (2) to dissolving and being diluted to 100% aqueous solution without alcohol taste, plus pure water, i.e., by life
Medicinal material meter, 100mL water Chinese medicines containing 100g；Be subsequently adding solution quality 0.1% activated carbon and solution quality 0.1% tween-
80, filtered after boiling 10 minutes, it is that 10% sodium hydroxide solution adjusts PH to 7.5 with mass percentage concentration, gone out using flowing steam
Bacterium, sterilizes 40 minutes at 105 DEG C, obtains final product the traditional Chinese medicine oral liquid that content of dispersion is 1g/mL.
2. the traditional Chinese medicine oral liquid of high-quality chicken cyanomycosis is prevented and treated obtained in preparation method according to claim 1.
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