CN102580036B - Veterinary Chinese medicine for improving immunity - Google Patents
Veterinary Chinese medicine for improving immunity Download PDFInfo
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- CN102580036B CN102580036B CN2012100678561A CN201210067856A CN102580036B CN 102580036 B CN102580036 B CN 102580036B CN 2012100678561 A CN2012100678561 A CN 2012100678561A CN 201210067856 A CN201210067856 A CN 201210067856A CN 102580036 B CN102580036 B CN 102580036B
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Abstract
The invention relates to the technical field of veterinary Chinese medicines, in particular to a veterinary Chinese medicine for improving immunity. The veterinary Chinese medicine is prepared from the following Chinese herbal medicines in part by weight: 5 parts of lovely hemsleya root, 10 parts of akebia stem, 13 parts of cape jasmine fruit, 3 parts of talc, 8 parts of ginger, 12 parts of golden mushroom, 15 parts of cinnamomvine, 15 parts of rehmannia root and 2 parts of pepper. A method for preparing the Chinese medicine comprises the following steps of: mixing the Chinese herbal medicines except for the lovely hemsleya root, crushing, and sieving with a 100-mesh sieve to obtain a primary mixture; and mixing the lovely hemsleya root and the primary mixture, crushing, sieving with a 100-mesh sieve, performing ultramicro crushing, and sieving with a 300-mesh sieve. The veterinary Chinese medicine comprises a few varieties of raw materials, has a good effect, is quick in response, does not have toxic or side effect, and has a good effect on the improvement of the immunity and survival rate of animals, the prevention of the infection of epidemic diseases and the adjuvant therapy of infectious diseases, and a preparation process is simple.
Description
technical field
The present invention relates to the veterinary Chinese medicine technical field, particularly a kind of Chinese medicine of raising immunity for animals.
background technology
Along with the deterioration of environment and the abuse of a lot of harmful substances, epidemic disease is more and more, also increasing to the harm of poultry, so cause its survival rate to descend or quality decline.Long-term a large amount of use of element given birth in family's poultry antagonism, and its negative interaction also more and more displays, and antibiotic has also killed probiotics when killing harmful bacteria.And family's poultry life-time service antibiotic not only produced the Drug resistance of antibacterial to medicine, make the poultry morbidity after Drug therapy invalid, drug residue and on the impact of a livestock products quality serious problem especially simultaneously.Traditional Chinese Medicine Chinese medicine because its toxicity is low, more and more be subject to the welcome in its feeding field without follow-up harm, the wide advantage of originating, but existing a lot of tcm product, that the Chinese medicine kind is many, cause cost of material high, it is complex process, be not suitable for large-scale application, or be that effect is not ideal enough, the drug effect performance is slow.
summary of the invention
For solve above Chinese medicine in beasts, apply have that cost of material is high, the problem of complex process, DeGrain, the invention provides that a kind of cost is low, the Chinese medicine of the raising immunity for animals for preparing simple, effective, instant effect.
The present invention is achieved by the following measures:
A kind of Chinese medicine of raising immunity for animals, by the crude drug of following weight portion, made:
5 parts of Radix Hemsleyae Macrospermae, 10 parts of Caulis Akebiaes, 13 parts of Fructus Gardeniaes, 3 parts, Talcum, 8 parts, Rhizoma Zingiberis Recens, 12 parts of JINZHENGU, 15 parts of Rhizoma Dioscoreaes, 15 parts of Radix Rehmanniae, 2 parts, Fructus Piperis.
Radix Hemsleyae Macrospermae: heat-clearing and toxic substances removing, benefiting stomach and stopping pain.Caulis Akebiae: clearing away heart-fire, diuresis, the stimulating milk secretion of stimulating the menstrual flow.Fructus Gardeniae has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence.The Talcum inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore.Rhizoma Zingiberis Recens is longer than dispersing wind-cold, preventing phlegm from forming and stopping coughing, again can warming middle-JIAO to arrest vomiting, removing toxic substances.The JINZHENGU tonifying liver, beneficial the intestines and stomach, anticancer.Rhizoma Dioscoreae have quench one's thirst promote the production of body fluid, the effect of health care, skin care.Radix Rehmanniae, the fresh tuber of plant Radix Rehmanniae, the effect that there is clearing away heat and cooling blood, promotes the production of body fluid and moisturize.Fructus Piperis has warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, expectorant, the effect of removing toxic substances.
The preparation method of described Chinese medicine, pulverized after the Chinese medicine except Radix Hemsleyae Macrospermae is mixed, and crosses 100 mesh sieves and obtain just mixed thing; Radix Hemsleyae Macrospermae is mixed with just mixed thing, pulverize, cross 100 mesh sieves, carry out micronizing, cross 300 mesh sieves.
Beneficial effect of the present invention: raw materials used kind is few, preparation technology is simple, effective, instant effect, have no side effect, to improving beasts immunity, improve survival rate, the prevention epidemic disease infects, the auxiliary treatment infectious disease is effective.
The specific embodiment
For a better understanding of the present invention, below in conjunction with specific embodiment, further illustrate.
embodiment 1:
A kind of Chinese medicine of raising immunity for animals, by the crude drug of following weight portion, made:
5 parts of Radix Hemsleyae Macrospermae, 10 parts of Caulis Akebiaes, 13 parts of Fructus Gardeniaes, 3 parts, Talcum, 8 parts, Rhizoma Zingiberis Recens, 12 parts of JINZHENGU, 15 parts of Rhizoma Dioscoreaes, 15 parts of Radix Rehmanniae, 2 parts, Fructus Piperis.
Preparation method: pulverized after the Chinese medicine except Radix Hemsleyae Macrospermae is mixed, cross 100 mesh sieves and obtain just mixed thing; Radix Hemsleyae Macrospermae is mixed with just mixed thing, pulverize, cross 100 mesh sieves, carry out micronizing, cross 300 mesh sieves.
the compliance test result experiment
experiment one
Colibacillosis is a kind of commonly encountered diseases, the frequently-occurring disease caused by escherichia coli, is that the especially the most serious bacterial disease of broiler production is produced in harm poultry at present.The purpose of this test is in order to verify that this medicine is to the clinical therapeutic efficacy of the above-mentioned several bacterial diseases of chicken and this medicine and the contrast of similar prescription coarse powder drug effect.
One, test material
1, trial drug: antibacterial Chinese medicine superfine powder of the present invention.
2, control drug: the colibacillary Chinese medicine preparation Chinese pulsatilla root submicron powder of commercially available treatment.
3, strain: chicken colibacillosis O
1,o
2,o
78, China Veterinery Drug Inspection Office provides.
4, test chicken: 7 age in days AA are public young, and poultry institute test site, academy of agricultural sciences, Shandong Province provides.
5, feedstuff: chickling perfect compound feed.
6, culture medium: nutrient broth, nutrient agar.
Two, test method:
1, increasing bacterium cultivation and viable count measures: escherichia coli are inoculated in common nutrient broth medium, cultivate 24 hours for 37 ℃.Through count plate, every milliliter contains the bacterium number over 1,800,000,000.The count plate concrete operation step is as follows: 10, test tube getting sterilizing, 4.5 milliliters of sterile salines are inside arranged, get 0.5 milliliter of tested bacterium liquid and be added to after the first pipe mixes and get 0.5 milliliter and add the second pipe, change suction pipe, successively the operation until the tenth the pipe, each titre is changed suction pipe No. one time.Dilute 0.1 milliliter of bacterium liquid with the sterilizing suction pipe in the tenth pipe, add in the sterilizing plate containing Nutrient agar, then draw successively the 9th pipe ... the first pipe, operate the samely, and each dilution factor is done three repetitions.It should be noted that during operation that the diluent that will make in every ware evenly paves in plate.Then plate is put to 37 ℃ and cultivated after 18 hours, select the plate count that bacterium colony is 30-300.
Viable count=extension rate in every milliliter * 10 * bacterial population.
2, counteracting toxic substances dosimetry: get 20 of test chickens, be divided at random 4 groups, the mixed vaccine culture fluid of having counted through intramuscular injection respectively, the 1st group is 0.1mL/ only (containing approximately 1.8 hundred million of viable bacterias), second group is 0.2mL/ only (containing approximately 3.6 hundred million of viable bacterias), the 3rd group is 0.3mL/ only (containing approximately 5.4 hundred million of viable bacterias), and the 4th group is 0.4mL/ only (containing approximately 7.2 hundred million of viable bacterias).After counteracting toxic substances 12 hours, 1 group has no dead, and 2 groups dead 2 (mortality rate is 40%), 3 groups dead 3 (mortality rate is 60%), 4 groups of counteracting toxic substances chickens are all dead.So counteracting toxic substances dosage only is decided to be to 0.2mL/.
3, test grouping: test is divided into 6 groups, every group of 30 chickens,
First group is high dose group, counteracting toxic substances, dosage is 1/100(10 gram/kilogram feedstuff), mixed feeding;
Second group is low dose group, counteracting toxic substances, dosage is 0.5/100(5 gram/kilogram feedstuff), mixed feeding;
The 3rd group is the loose matched group of the Radix Pulsatillae, counteracting toxic substances, dosage is 0.5/100(5 gram/kilogram feedstuff), mixed feeding;
The 4th group is the blank group, counteracting toxic substances not, not medication;
The 5th group is the counteracting toxic substances matched group, a counteracting toxic substances, not medication.
4, counteracting toxic substances: during chickling 10 age in days, by mixed bacteria liquid, through intramuscular injection, only, test group adds the medicine of various dose to 0.2mL/ after counteracting toxic substances in feedstuff after 12 hours, continuous use 5 days.
5, clinical observation: Continuous Observation two weeks, observe clinical symptoms every day, calculate medicine effective percentage, protective rate and cure rate.
Three, result of the test
After chickling counteracting toxic substances 6 hours.Occur being afraid of cold, flock together, lassitude, search for food and reduce or do not eat, the symptoms such as row's brown color loose stool.And Mortality appears.Within after counteracting toxic substances 12 hours, start dispensing, continuous use 5 days.Only cutd open inspection to dying of illness, visible chicken liver edge has petechia, Pulmonary hemorrhage, and the air bag exudate is yellow muddy, and, with pericarditis, presents the typical cytopathic of colibacillosis.The antibacterial that will separate from liver is streak culture on Yihong-methylene blue differential medium, and bacterium colony is atropurpureus, and, with metallic luster, is colibacillary typical case's performance.
Matched group, high and low dose test group, after 12 hours, visible feed intake has increased slightly, and sick chicken spirit takes a turn for the better, and within the 3rd day, stops death, and within the 5th day, the chicken group recovers normal substantially.The clinical observation confirmation, high and low dose group treatment antibacterial infectious effect obviously is better than control drug.Each group survival number and death toll are in Table 1.
Each group survival number of table 1, death toll data statistic
| ? | High dose | Low dosage | The medicine contrast | Blank | The counteracting toxic substances contrast |
| The survival number | 29 | 27 | 23 | 25 | 12 |
| Death toll | 1 | 3 | 7 | 5 | 18 |
experiment two
Duck, pig are divided into groups respectively to raise, one group is added Chinese medicine of the present invention when feeding in feedstuff, addition is 10g/kg feedstuff sky, another group as a control group, is not added Chinese medicine of the present invention, in addition in feedstuff, the raising condition of two groups is controlled identical, individual variation in two groups is controlled in the reasonable scope, raises and adds up after two months sickness rate and mortality rate, sees the following form 2.
Infectious disease incidence and experience table are raised in table 2 duck, pig grouping
By above experiment, can be found out, after edible Chinese medicine of the present invention, the probability that chicken, duck, pig infect infectious disease reduces, mortality rate all is reduced to very low level, illustrate that Chinese medicine of the present invention can improve beasts immunity, improve resistance against diseases, greatly reduce like this cost of raising, increasing income, is a technology be worthy to be popularized.
Claims (1)
1. the Chinese medicine of a raising immunity for animals is characterized in that being made by the crude drug of following weight portion:
5 parts of Radix Hemsleyae Macrospermae, 10 parts of Caulis Akebiaes, 13 parts of Fructus Gardeniaes, 3 parts, Talcum, 8 parts, Rhizoma Zingiberis Recens, 12 parts of JINZHENGU, 15 parts of Rhizoma Dioscoreaes, 15 parts of Radix Rehmanniae, 2 parts, Fructus Piperis;
Pulverized after Chinese medicine except Radix Hemsleyae Macrospermae is mixed, cross 100 mesh sieves and obtain just mixed thing; Radix Hemsleyae Macrospermae is mixed with just mixed thing, pulverize, cross 100 mesh sieves, carry out micronizing, cross 300 mesh sieves.
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| CN2012100678561A CN102580036B (en) | 2012-03-15 | 2012-03-15 | Veterinary Chinese medicine for improving immunity |
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| CN2012100678561A CN102580036B (en) | 2012-03-15 | 2012-03-15 | Veterinary Chinese medicine for improving immunity |
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| CN102580036A CN102580036A (en) | 2012-07-18 |
| CN102580036B true CN102580036B (en) | 2013-12-11 |
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| CN105816835A (en) * | 2016-04-23 | 2016-08-03 | 张瑞武 | Traditional Chinese medicine composition for capable of improving livestock immunity and preparation method of traditional Chinese medicine composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133389A (en) * | 2011-04-06 | 2011-07-27 | 山东省农业科学院畜牧兽医研究所 | Disinfectant traditional Chinese medicine for livestock and poultry |
| CN102258635A (en) * | 2011-07-15 | 2011-11-30 | 山东省农业科学院畜牧兽医研究所 | Antibacterial Chinese medicine for veterinary use |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133389A (en) * | 2011-04-06 | 2011-07-27 | 山东省农业科学院畜牧兽医研究所 | Disinfectant traditional Chinese medicine for livestock and poultry |
| CN102258635A (en) * | 2011-07-15 | 2011-11-30 | 山东省农业科学院畜牧兽医研究所 | Antibacterial Chinese medicine for veterinary use |
Non-Patent Citations (1)
| Title |
|---|
| 张保平.发展中药饲料添加剂，生产中国绿色畜产品.《河南畜牧兽医》.1999,第20卷(第12期),第24-26页. * |
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Owner name: SHANDONG JIANMU BIOLOG PHARMACEUTICAL CO.,LTD. Effective date: 20131105 Owner name: ZHANG WEI Free format text: FORMER OWNER: SHANDONG JIANMU BIOLOG PHARMACEUTICAL CO.,LTD. Effective date: 20131105 |
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Inventor after: Zhang Wei Inventor after: Qin Zhuoming Inventor after: Zhang Zaihui Inventor after: Huang Dihai Inventor after: Liu Xia Inventor after: Xu Huaiying Inventor after: Chen Lingmei Inventor after: Wang Youling Inventor after: Liu Shimei Inventor before: Zhang Wei Inventor before: Qin Zhuoming Inventor before: Zhang Zaihui Inventor before: Liu Xia Inventor before: Zhang Hua Inventor before: Huang Haidi |
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Free format text: CORRECT: INVENTOR; FROM: ZHANG WEI QIN ZHUOMING ZHANG ZAIHUI LIU XIA ZHANG HUA HUANG HAIDI TO: ZHANG WEI QIN ZHUOMING ZHANG ZAIHUI HUANG DIHAI LIU XIA XU HUAIYING CHEN LINGMEI WANG YOULING LIU SHIMEI |
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Effective date of registration: 20131105 Address after: Industrial Road Licheng District, Ji'nan city of Shandong Province, No. 202 250100 Applicant after: Zhang Wei Applicant after: Shandong Jianmu Biological Pharmaceutical Co., Ltd. Address before: Mulberry road Licheng District 250100 in Shandong city of Ji'nan province No. 4 Applicant before: Shandong Jianmu Biological Pharmaceutical Co., Ltd. |
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