CN103844143A - Chinese herbal compound feed additive preventing streptococcicosis for tilapia mossambica - Google Patents
Chinese herbal compound feed additive preventing streptococcicosis for tilapia mossambica Download PDFInfo
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- CN103844143A CN103844143A CN201410088164.4A CN201410088164A CN103844143A CN 103844143 A CN103844143 A CN 103844143A CN 201410088164 A CN201410088164 A CN 201410088164A CN 103844143 A CN103844143 A CN 103844143A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Abstract
The invention discloses a Chinese herbal compound feed additive preventing streptococcicosis for tilapia mossambica. The Chinese herbal compound feed additive is prepared from the following Chinese herbal medicines in parts by weight: 20-30 parts of coptis chinensis, 20-30 parts of scutellaria baicalensis, 20-30 parts of fructus forsythia and 20-30 parts of dioscorea bulbifera L. The Chinese herbal compound feed additive disclosed by the invention is prepared from pure natural medicines and obtained by virtue of reasonable proportioning, and has the advantages of being low in residue, low in drug resistance, free of toxic and side effect, good in preventing effect, and the like. A test proves that when the additive disclosed by the invention is applied in a targeted manner while diseases easily attack, the tilapia mossambica can be effectively prevented from streptococcicosis.
Description
Technical field
The invention belongs to compound Chinese herbal medicinal feed additive technical field, relate in particular to a kind of Tilapia mossambica prevention streptococcosis compound Chinese herbal medicinal feed additive.
Background technology
Streptococcus is that one is distributed widely in natural hemolytic gram-positive bacteria, often causes mammal disease, the special susceptible mankind and Niu.Streptococcus is also one of the most serious aquatic pathogen of nearly ten years fresh water and marine fish, and temperate water fishes is subject to streptococcic harm even more serious.
In global tropical and subtropical region, Tilapia mossambica has the cultivation history of decades, is with a long history.China has become Tilapia mossambica big producing country in the world at present, and Chinese Tilapia mossambica cultivation annual production ranks first in the world.Except the highlands such as Tibet and Qinghai, Tilapia mossambica extensively cultivates in 30 Duo Ge provinces and cities of China.But streptococcosis each department outbreak of epidemic at home, causes large quantities of Tilapia mossambica death in recent years, cause tremendous economic loss.
The fish of morbidity will be treated in time, still, as a rule, oral antibiotic poor effect, main cause is that antibiotic adopts and mixes to raise and throw something and feed, and infected fish has almost been remained silent and stops eating; Throw something and feed during antibiotic, though can to a certain degree reduce the death rate of disease fish, once so stop to feed, the death rate can increase again.In such cases, raiser usually extends the medicine feed time or increases dosage, and this induced mbc bacterial strain generation again, also can cause flesh of fish drug residue." anti-overweighting controlled " emphasized in control for Tilapia mossambica streptococcosis, there is no at present efficient commercialized vaccine and can prevent Tilapia mossambica streptococcosis.Chinese herbal and crude drugs preparations is as natural drug, because the feature of its low-residual, low resistance becomes the research direction of preventing and treating streptococcosis future.
Summary of the invention
Prevention streptococcosis compound Chinese herbal medicinal feed additive for the Tilapia mossambica that the technical problem to be solved in the present invention is to provide a kind of pure natural extraction, low-residual, low resistance, has no side effect, prevention effect is good.
For solving the problems of the technologies described above, the present invention is by the following technical solutions: prevention streptococcosis compound Chinese herbal medicinal feed additive for Tilapia mossambica, is prepared from by the Chinese herbal medicine of following weight portion: 20～30 parts of the coptiss, 20～30 parts of the roots of large-flowered skullcap, 20～30 parts of the capsules of weeping forsythia, 20～30 parts of airpotato yams.
Above-mentioned feed addictive, by Chinese herbal medicine powder comminution powdered, adopts decoction alcohol precipitation method to extract, more concentrated through rotary evaporation, to obtain final product.
Decoction alcohol precipitation method comprises the following steps: take 20～30 parts of the coptiss, 20～30 parts of the roots of large-flowered skullcap, 20～30 parts of the capsules of weeping forsythia, 20～30 parts of airpotato yams, by mass volume ratio, 1:5 soaks 0.5h, and 100 DEG C of water-bath 1h afterwards filter; Filter residue, again by the mass volume ratio 1:5 continuation water-bath that adds water, filters, and repeats twice; Gained filtrate merges, the centrifugal 30min of 3000r/min; Supernatant is concentrated in Rotary Evaporators, adds 95% alcohol, makes mixed liquor concentration of alcohol reach 80%, leaves standstill 24h, and rotary evaporation recovered alcohol to liquor strength is 1g/mL; 115 DEG C of autoclaving 15min ,-20 DEG C save backup.
The using method of above-mentioned feed addictive, admixes basal feed by additive by 60～160mL liquid/kg feed and throws something and feeds.
Lack the problem of safe and effective medicine for Tilapia mossambica streptococcosis, inventor adopts pure Chinese herbal medicine, has obtained Tilapia mossambica of the present invention prevention streptococcosis compound Chinese herbal medicinal feed additive through rational proportion.Concrete side analyses as follows: the coptis is the rhizome of the ranunculaceae plant coptis, the triangle leaf coptis, coptis omeiensis or rhizoma coptidis teetoidis, there is antiulcer, gastric acid secretion inhibiting, anti-inflammatory and antalgic, bacteriostasis, stronger to gold-coloured staphylococci, comma bacillus, streptococcus effect; The root of large-flowered skullcap is the dry root of the labiate root of large-flowered skullcap, is conventional Chinese herbal medicine, and its bitter is cold in nature, has heat-clearing and damp-drying drug, purging intense heat and detonicating, antibacterial action; The root (weeping forsythia root) of the capsule of weeping forsythia, also hyoscine of cauline leaf (weeping forsythia leaf), have antibacterial, cardiac stimulant, diuresis, town the pharmacological action such as to tell; Airpotato yam is the stem tuber of monocotyledon Dioscoreaceae air potato, has removing toxicity for detumescence, the effects such as anti-inflammation, reducing phlegm and resolving masses, cooling blood and hemostasis.
The present invention derives from pure natural medical, has low-residual, low resistance, has no side effect, the advantage such as prevention effect is good.Evidence, is used additive of the present invention targetedly in the time of susceptible disease, can effectively prevent the generation of Tilapia mossambica streptococcosis.
Detailed description of the invention
The preparation of prevention streptococcosis compound Chinese herbal medicinal feed additive for embodiment 1 Tilapia mossambica
Prevention streptococcosis compound Chinese herbal medicinal feed additive formula for table 1 Tilapia mossambica
| Sequence number | The coptis | The root of large-flowered skullcap | The capsule of weeping forsythia | Airpotato yam |
| 1 | 20g | 20g | 30g | 30g |
| 2 | 30g | 25g | 25g | 20g |
| 3 | 25g | 25g | 25g | 25g |
| 4 | 25g | 30g | 25g | 20g |
| 5 | 20g | 25g | 25g | 30g |
The formula of reference table 1, get Chinese herbal medicine and prepare respectively the additive of formula one to five, first by Chinese herbal medicine powder comminution powdered, employing decoction alcohol precipitation method extracts, more concentrated through rotary evaporation, to obtain final product, specific as follows: to take each raw material by formula, by mass volume ratio, 1:5 soaks 0.5h, and 100 DEG C of water-bath 1h afterwards filter; Filter residue, again by the mass volume ratio 1:5 continuation water-bath that adds water, filters, and repeats twice; Gained filtrate merges, the centrifugal 30min of 3000r/min; Supernatant is concentrated in Rotary Evaporators, adds 95% alcohol, makes mixed liquor concentration of alcohol reach 80%, leaves standstill 24h, and rotary evaporation recovered alcohol to liquor strength is 1g/mL; 115 DEG C of autoclaving 15min ,-20 DEG C save backup.
Using method: use and prevent epidemic targetedly at high temperature season, to prevent the generation of disease.Formula 1 to 5 liquid is pressed respectively to liquid feed ratio 60,80,100,120,160mL/kg, it is evenly sprayed on the basal diet of respective quality with sprayer, mix, it is fully absorbed by feed, the 24h that dries in the shade is for subsequent use.By containing throwing something and feeding by 3% amount of body weight additive feed every day, use continuously 7 days.Result: after infecting control group morbidity, the death rate reaches 95.83%, and the control drug Florfenicol treatment group death rate is 70.83%, and protective rate is 26.08%.Compound Chinese herbal medicinal feed additive preventive effect is remarkable; the protective rate of high dose group (120ml/kg), middle dosage group (60ml/kg), low dose group (30ml/kg) is respectively 47.82%, 34.78%, 26.08%, all apparently higher than Florfenicol treatment group and infection control group.
The research of compound Chinese herbal medicinal feed additive to Tilapia mossambica streptococcosis preventive effect
1 material method
1.1 material
(1) bacterium is used in experiment
Streptococcusagalactiae clinical separation strain, separates qualification by Guangxi University's pharmacological evaluation chamber and preserves.Experiment bacterium rejuvenation: bacterial classification streak inoculation, in sheep blood plate culture medium, is cultivated 16～18h for 37 DEG C.The single bacterium colony of picking, is seeded in 5% serum brain heart leachate broth bouillon, and 37 DEG C are cultured to 16～18h.When use, use 10 times of diluted for use of physiological saline.
(2) experimental drug
Compound Chinese herbal medicinal feed additive (by embodiment 13 preparations of filling a prescription).
Florfenicol, purchased from Beijing Hua Bang animal pharmaceutical estate Co., Ltd
(3) Experimental fish
Gift tilapia (the long 8～15cm of body weight 50～100g/ body), by Guangxi, aquatic products research institute provides.
1.2 method
(1) preparation of herbal mixture feed addictive
Method for making is with embodiment 1.
Liquid, respectively by certain liquid feed ratio (mL/kg), is evenly sprayed on it on basal diet of respective quality with sprayer, mixes, it is fully absorbed by feed, the 24h that dries in the shade is for subsequent use.Florfenicol addition is 0.05g/kg.
(2) Experimental fish is prepared
Adopt gift tilapia (the long 8～15cm of body weight 50～100g/ body), by Guangxi, aquatic products research institute provides, in 1 cubic metre of large water vat of experiment Qian Zanyangyu aquatic products research institute.
(3) bacterium is used in experiment
Before experiment, get bacterial classification, rule and purely carry out pure culture in blood plate.Cultivate 16～18h for 37 DEG C.Wash lower bacterium colony with physiological saline again, adopt turbidimetry to be configured to 7.5 × 108CFU/mL bacterium liquid for subsequent use.
(4) experiment is processed
Get Tilapia mossambica 180 tails, be divided into and infect not administration group, low dose group (30ml/kg), middle dosage group (60ml/kg), high dose group (120ml/kg), Florfenicol control group and physiological saline control group.Infect control group and physiological saline control group only to blank material, all the other the each group corresponding pastille feed of throwing something and feeding.Throw something and feed and within 7 days, carry out lumbar injection afterwards with Streptococcusagalactiae clinical separation strain and attack poison, attacking toadstool amount is 7.5 × 10
8cFU/mL, every tail 0.2Ml.Attack the rear observation of poison 7 days, statistics Tilapia mossambica death condition, and observe the illness variation of attacking the rear Tilapia mossambica of poison.Dead Tilapia mossambica takes brain tissue to be inoculated in blood plate in 37 DEG C of cultivations, observes and has or not streptococcus growth.Calculate the protective rate of prescription to Tilapia mossambica by each group of fish death toll.Protective rate computational methods: protective rate=(positive infected group death toll-test group death toll)/positive infected group death toll × 100%.
2 experimental results
Attacking latter 7 days each group death condition of poison adds up as table 2:
Table 2 experimental result
| Date | 30ml/kg | 60ml/kg | 120ml/kg | Florfenicol | Blank | Negative control |
| Sum | 24 | 24 | 24 | 24 | 24 | 24 |
| Death toll | 17 | 15 | 12 | 17 | 23 | 0 |
| Residue | 7 | 9 | 12 | 7 | 1 | 24 |
| The death rate | 70.83% | 62.50% | 50% | 70.83% | 95.83% | 0% |
| Protective rate | 26.08% | 34.78% | 47.82% | 26.08% | ? | ? |
Dead fish is taked to brain tissue inoculation blood plate, all find that there is streptococcus growth through cultivating.After the 7th day, do not find dead fish, survival Tilapia mossambica is all put to death, and takes brain tissue to be inoculated in blood plate, generates there are no streptococcus.
3 experiment conclusion
Feed addictive of the present invention can effectively prevent the generation of Tilapia mossambica streptococcosis, has obtained expected result, is worth further developing.
Claims (4)
1. a prevention streptococcosis compound Chinese herbal medicinal feed additive for Tilapia mossambica, is characterized in that being prepared from by the Chinese herbal medicine of following weight portion: 20～30 parts of the coptiss, 20～30 parts of the roots of large-flowered skullcap, 20～30 parts of the capsules of weeping forsythia, 20～30 parts of airpotato yams.
2. feed addictive according to claim 1, is characterized in that: by Chinese herbal medicine powder comminution powdered, adopt decoction alcohol precipitation method to extract, more concentrated through rotary evaporation, to obtain final product.
3. feed addictive according to claim 2, it is characterized in that described decoction alcohol precipitation method comprises the following steps: take 20～30 parts of the coptiss, 20～30 parts of the roots of large-flowered skullcap, 20～30 parts of the capsules of weeping forsythia, 20～30 parts of airpotato yams, by mass volume ratio, 1:5 soaks 0.5h, 100 DEG C of water-bath 1h afterwards, filter; Filter residue, again by the mass volume ratio 1:5 continuation water-bath that adds water, filters, and repeats twice; Gained filtrate merges, the centrifugal 30min of 3000r/min; Supernatant is concentrated in Rotary Evaporators, adds 95% alcohol, makes mixed liquor concentration of alcohol reach 80%, leaves standstill 24h, and rotary evaporation recovered alcohol to liquor strength is 1g/mL; 115 DEG C of autoclaving 15min ,-20 DEG C save backup.
4. the using method of feed addictive described in claim 1, is characterized in that: additive is admixed to basal feed by 60～160mL liquid/kg feed and throw something and feed.
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104472873A (en) * | 2014-11-18 | 2015-04-01 | 广东海因特生物技术集团有限公司 | Feed additive for improving liver function of tilapia and preventing streptococcicosis |
| CN105341352A (en) * | 2015-12-15 | 2016-02-24 | 李国深 | Feed additive for preventing streptococcus agalactiae |
| CN106036205A (en) * | 2016-05-30 | 2016-10-26 | 青岛海之源智能技术有限公司 | Feed additive capable of treating streptococcal disease of tilapia and preparation method of feed additive |
| CN106071347A (en) * | 2016-05-30 | 2016-11-09 | 青岛海之源智能技术有限公司 | Feed additive of preventing and treating epinephelus akaara streptococcicosis and preparation method thereof |
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| CN104472873B (en) * | 2014-11-18 | 2017-07-21 | 广东海因特生物技术集团有限公司 | A kind of feed addictive for improving liver of hybrid tilapia function, preventing streptococcosis |
| CN104472873A (en) * | 2014-11-18 | 2015-04-01 | 广东海因特生物技术集团有限公司 | Feed additive for improving liver function of tilapia and preventing streptococcicosis |
| CN105341352A (en) * | 2015-12-15 | 2016-02-24 | 李国深 | Feed additive for preventing streptococcus agalactiae |
| CN106036205A (en) * | 2016-05-30 | 2016-10-26 | 青岛海之源智能技术有限公司 | Feed additive capable of treating streptococcal disease of tilapia and preparation method of feed additive |
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| CN106721005A (en) * | 2016-12-16 | 2017-05-31 | 新昌县柏克动物饲料技术开发有限公司 | Tilapia mossambica prevention streptococcosis feed addictive |
| CN106728619A (en) * | 2017-03-06 | 2017-05-31 | 长沙瑞多康生物科技有限公司 | A kind of composition for preventing and treating fish streptococcosis |
| CN106860630A (en) * | 2017-03-06 | 2017-06-20 | 长沙瑞多康生物科技有限公司 | A kind of composition for preventing and treating fish streptococcosis |
| CN106937994A (en) * | 2017-03-30 | 2017-07-11 | 广州市普精生物科技有限公司 | It is a kind of to prevent and treat composition of streptococcosis and its preparation method and application |
| CN108041274A (en) * | 2017-11-29 | 2018-05-18 | 杨韶彰 | Prevent the compound Chinese herbal medicinal feed additive of Tilapia mossambica streptococcosis |
| CN108124793A (en) * | 2017-12-26 | 2018-06-08 | 广西金海环岛渔业有限公司 | Improve the cultural method of Tilapia quality |
| CN108420922A (en) * | 2018-04-12 | 2018-08-21 | 广西大学 | Anti- Tilapia mossambica streptococcosis Chinese herbal and crude drugs preparations and its preparation process |
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