CN104971132A - Traditional Chinese medicine preparation for preventing and treating skin ulcer disease of octopus variabilis - Google Patents
Traditional Chinese medicine preparation for preventing and treating skin ulcer disease of octopus variabilis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for preventing and treating skin ulcer disease of octopus variabilis. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine materials in parts by weight: 16-20 parts of scutellaria baicalensis, 16-20 parts of jasmine, 12-18 parts of radix sophorae flavescentis, 8-12 parts of fructus forsythiae, 12-18 parts of capejasmine, 12-18 parts of polygonum cuspidatum, 2-6 parts of radix achyranthis bidentatae, 8-11 parts of houttuynia cordata and 2-6 parts of Chinese galls. The traditional Chinese medicines are reasonably matched, so that the effects of inhibiting bacteria and diminishing inflammation as well as enhancing immunity are extremely remarkable, a drug for effectively treating skin ulcer disease of octopus variabilis is provided for the aquaculture industry, and the traditional Chinese medicine preparation has the characteristics of high effect taking speed, exact curative effect, no medicine residue and no any toxic or side effects. By using the traditional Chinese medicine preparation, the skin ulcer disease of octopus variabilis can be effectively controlled, and the morbidity and mortality rates of the skin ulcer disease can be reduced.
Description
Technical field
The invention belongs to fishery practical technique field, in particular to a kind of Chinese medicine preparation for preventing and treating the long Octopus ocellatus Gray Disease of skin fester of aquatic animal and preparation method thereof.
Background technology
Long Octopus ocellatus Gray Octopus minor (Sasaki; 1920) be subordinate to Mollusca, Cephalopoda, Octopus ocellatus Gray section, this species skin can secrete a large amount of mucus, makes skin be rich in mucosity; also can form effective physical protection barrier on surface, protection health is from the invasion and attack of pathogenic microorganism simultaneously.The Disease of skin fester of long Octopus ocellatus Gray is breeding, supports temporarily and commonly encountered diseases in aquaculture process, generally or trunk parasitic by parasite, wrist are subject to mechanical injuries secondary bacterial, fungus etc. and infect the inflammation causing skin histology, affected area is then downright bad, tissue loss forms defect, even rotten to the corn, finally cause individual death.Disease of skin fester all can occur throughout the year, and treatment difficulty is large, the principle that the control for this disease must be adhered to " put prevention first, anti-overweighting is controlled ".
Chinese herbal medicine belongs to natural drug, at the application and research of China, has accumulated rich experience.Utilize Chinese herbal medicine to prevent and treat long Octopus ocellatus Gray Disease of skin fester more and more by attention and the favor of people, and be widely accepted, inseparable with the mechanism of action of its uniqueness, model of action and advantage, put it briefly, herbal control disease has Accommodation, strengthening vital QI to eliminate pathogenic factors, has no drug resistance and characteristics and advantages that the other medicines such as nuisanceless are incomparable, effective, and there is not the residue problem of antibiotic medicine, highly beneficial to China's fishery products outlet.The advantages such as in addition, Chinese herbal medicine also has low price, wide material sources, easy to use, have become the important means of aquiculture disease control and treatment.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for preventing and treating long Octopus ocellatus Gray Disease of skin fester.
The object of the present invention is achieved like this:
For preventing and treating a raw material of Chinese medicine drug composition for long Octopus ocellatus Gray Disease of skin fester, be prepared from by the Chinese crude drug of following weight portion: Radix Scutellariae 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentis 12-18, Fructus Forsythiae 8-12 part, Fructus Gardeniae 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba Houttuyniae 8-11 part, Galla Chinensis 2-6 part.
Preferably, the described raw material of Chinese medicine drug composition for preventing and treating long Octopus ocellatus Gray Disease of skin fester, is prepared from by the Chinese crude drug of following weight portion: Radix Scutellariae 18 parts, Fructus Gardeniae 18 parts, Radix Sophorae Flavescentis 16, Fructus Forsythiae 10 parts, Fructus Gardeniae 16 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Achyranthis Bidentatae 4 parts, Herba Houttuyniae 9 parts, Galla Chinensis 4 parts.
A kind of Chinese medicine preparation, be process preparation by above-mentioned crude drug compositions, its a kind of preparation method is as follows:
The first step, prepare clear paste powder:
1) get the raw materials ready: take the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, for subsequent use;
2) decoct: decoct with water, first decocts 8 times that every tank adds water as medical material total amount, and keep 2 hours after ebuillition of heated, extracting solution enters settling tank through 200 order metre filter; Second decocts the water heating extraction adding medical material amount 6 times, and protect and boil 1.5 hours, extracting solution enters settling tank through 200 order metre filter;
3) precipitate: in settling tank, extracting solution precipitates 12 hours, extract supernatant through 200 order metre filter in triple effect evaporator, precipitate is by offal treatment;
4) it is concentrated: when to be concentrated into relative density in triple effect evaporator be 1.05 ~ 1.10 (40 DEG C of mensuration) to supernatant, by rare clear paste in 200 order metre filter suction vacuum decompressioning and concentrating tanks, add ethanol to alcohol content 60% (v/v), place, filter; Concentrate and be mixed to when relative density is 1.10 ~ 1.22 (90 DEG C of mensuration) and go out cream, in storage cream bucket, for subsequent use;
5) dry: wherein vacuum: 0.01MPa, temperature: 78 ~ 82 DEG C, 12 ~ 18 hours drying times;
6) powder is beaten: smashing fineness 80 mesh sieve, obtains clear paste powder;
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1 ~ 3:0.1 ~ 0.3 takes clear paste powder, dextrin and 55% ethanol, and wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%;
3rd step, drops in trough type mixing machine by clear paste powder and starch, stirs 20 minutes, slowly adds 55% ethanol while stirring, to making soft material, granulates with 12 order stainless steel sifts, and 60 ~ 70 DEG C of dryings 2 hours, take out, cool and obtain described granule.
The consumption of above-mentioned control long Octopus ocellatus Gray Disease of skin fester Chinese medicine granules is mix pharmaceutical chemistry in the ratio of 50-80g/100kg body weight, makes long Octopus ocellatus Gray oral, and being used in conjunction 5-7 days is a course for the treatment of.
Apply Chinese medicine preparation of the present invention and effectively can control long Octopus ocellatus Gray Disease of skin fester, reduce the M & M of long Octopus ocellatus Gray Disease of skin fester, but also do not produce drug resistance.The present invention is by Chinese medicine reasonable formula, effect of anti-inflammation, enhancing immunity is very remarkable, for culture fishery provides a kind of effective medicine of long Octopus ocellatus Gray Disease of skin fester, have instant effect, curative effect really, no drug residue, feature without any side effects; Its preparation method is simple, is applicable to the needs that large-scale industrial is produced.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Embodiments of the invention are only used for the present invention is described, instead of limitation of the present invention, under concept thereof of the present invention, all belong to the scope of protection of present invention to the simple modifications of preparation method of the present invention.Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese medicine granules preventing and treating long Octopus ocellatus Gray Disease of skin fester, be made up of Radix Scutellariae, Fructus Gardeniae, Radix Sophorae Flavescentis, Fructus Forsythiae, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba Houttuyniae, Galla Chinensis, wherein, Radix Scutellariae 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentis 16kg, Fructus Forsythiae 10kg, Fructus Gardeniae 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Herba Houttuyniae 9kg, Galla Chinensis 4kg.
The preparation method of the Chinese medicine granules of the long Octopus ocellatus Gray Disease of skin fester of above-mentioned control, concrete preparation process is as follows:
The first step, prepare clear paste powder:
1) get the raw materials ready: taking Radix Scutellariae 18kg, Fructus Gardeniae 18kg, Radix Sophorae Flavescentis 16kg, Fructus Forsythiae 10kg, Fructus Gardeniae 16kg, Rhizoma Polygoni Cuspidati 14kg, Radix Achyranthis Bidentatae 4kg, Herba Houttuyniae 9kg, Galla Chinensis 4kg is clearly raw material, wash clean Chinese crude drug, pulverize, for subsequent use;
2) decoct: decoct with water, first decocts 8 times that every tank adds water as medical material total amount, and keep 2 hours after ebuillition of heated, extracting solution enters settling tank through 200 order metre filter; Second decocts the water heating extraction adding medical material amount 6 times, and protect and boil 1.5 hours, extracting solution enters settling tank through 200 order metre filter;
3) precipitate: in settling tank, extracting solution precipitates 12 hours, extract supernatant through 200 order metre filter in triple effect evaporator, precipitate is by offal treatment;
4) it is concentrated: when to be concentrated into relative density in triple effect evaporator be 1.05 ~ 1.10 (40 DEG C of mensuration) to supernatant, by rare clear paste in 200 order metre filter suction vacuum decompressioning and concentrating tanks, add ethanol to alcohol content 60% (v/v), place, filter; Concentrate and be mixed to when relative density is 1.10 ~ 1.22 (90 DEG C of mensuration) and go out cream, in storage cream bucket, for subsequent use;
5) dry: wherein vacuum: 0.01MPa, temperature: 78 ~ 82 DEG C, 12 ~ 18 hours drying times;
6) powder is beaten: smashing fineness 80 mesh sieve, obtains clear paste powder;
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1 ~ 3:0.1 ~ 0.3 takes clear paste powder, dextrin and 55% ethanol, and wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%;
3rd step, drops in trough type mixing machine by clear paste powder and starch, stirs 20 minutes, slowly adds 55% ethanol while stirring, to making soft material, granulates with 12 order stainless steel sifts, and 60 ~ 70 DEG C of dryings 2 hours, take out, cool and obtain described granule.
Embodiment 2
A kind of Chinese medicine granules preventing and treating long Octopus ocellatus Gray Disease of skin fester, be made up of Radix Scutellariae, Fructus Gardeniae, Radix Sophorae Flavescentis, Fructus Forsythiae, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba Houttuyniae, Galla Chinensis, wherein, Radix Scutellariae 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Herba Houttuyniae 10kg, Galla Chinensis 5kg.
The preparation method of the Chinese medicine granules of the long Octopus ocellatus Gray Disease of skin fester of above-mentioned control, concrete preparation process is as follows:
The first step, prepare clear paste powder:
1) get the raw materials ready: take Radix Scutellariae 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Herba Houttuyniae 10kg, Galla Chinensis 5kg be raw material, wash clean Chinese crude drug, pulverizes, for subsequent use;
2) decoct: decoct with water, first decocts 8 times that every tank adds water as medical material total amount, and keep 2 hours after ebuillition of heated, extracting solution enters settling tank through 200 order metre filter; Second decocts the water heating extraction adding medical material amount 6 times, and protect and boil 1.5 hours, extracting solution enters settling tank through 200 order metre filter;
3) precipitate: in settling tank, extracting solution precipitates 12 hours, extract supernatant through 200 order metre filter in triple effect evaporator, precipitate is by offal treatment;
4) it is concentrated: when to be concentrated into relative density in triple effect evaporator be 1.05 ~ 1.10 (40 DEG C of mensuration) to supernatant, by rare clear paste in 200 order metre filter suction vacuum decompressioning and concentrating tanks, add ethanol to alcohol content 60% (v/v), place, filter; Concentrate and be mixed to when relative density is 1.10 ~ 1.22 (90 DEG C of mensuration) and go out cream, in storage cream bucket, for subsequent use;
5) dry: wherein vacuum: 0.01MPa, temperature: 78 ~ 82 DEG C, 12 ~ 18 hours drying times;
6) powder is beaten: smashing fineness 80 mesh sieve, obtains clear paste powder;
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1 ~ 3:0.1 ~ 0.3 takes clear paste powder, dextrin and 55% ethanol, and wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%;
3rd step, drops in trough type mixing machine by clear paste powder and starch, stirs 20 minutes, slowly adds 55% ethanol while stirring, to making soft material, granulates with 12 order stainless steel sifts, and 60 ~ 70 DEG C of dryings 2 hours, take out, cool and obtain described granule.
Embodiment 3
A kind of Chinese medicine granules preventing and treating long Octopus ocellatus Gray Disease of skin fester, be made up of Radix Scutellariae, Fructus Gardeniae, Radix Sophorae Flavescentis, Fructus Forsythiae, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba Houttuyniae, Galla Chinensis, wherein, Radix Scutellariae 20kg, Fructus Gardeniae 20kg, Radix Sophorae Flavescentis 18kg, Fructus Forsythiae 12kg, Fructus Gardeniae 18kg, Rhizoma Polygoni Cuspidati 18kg, Radix Achyranthis Bidentatae 6kg, Herba Houttuyniae 11kg, Galla Chinensis 6kg.
The preparation method of the Chinese medicine granules of the long Octopus ocellatus Gray Disease of skin fester of above-mentioned control, concrete preparation process is as follows:
The first step, prepare clear paste powder:
1) get the raw materials ready: take Radix Scutellariae 19kg, Fructus Gardeniae 17kg, Radix Sophorae Flavescentis 15kg, Fructus Forsythiae 9kg, Fructus Gardeniae 14kg, Rhizoma Polygoni Cuspidati 13kg, Radix Achyranthis Bidentatae 3kg, Herba Houttuyniae 10kg, Galla Chinensis 5kg be raw material, wash clean Chinese crude drug, pulverizes, for subsequent use;
2) decoct: decoct with water, first decocts 8 times that every tank adds water as medical material total amount, and keep 2 hours after ebuillition of heated, extracting solution enters settling tank through 200 order metre filter; Second decocts the water heating extraction adding medical material amount 6 times, and protect and boil 1.5 hours, extracting solution enters settling tank through 200 order metre filter;
3) precipitate: in settling tank, extracting solution precipitates 12 hours, extract supernatant through 200 order metre filter in triple effect evaporator, precipitate is by offal treatment;
4) it is concentrated: when to be concentrated into relative density in triple effect evaporator be 1.05 ~ 1.10 (40 DEG C of mensuration) to supernatant, by rare clear paste in 200 order metre filter suction vacuum decompressioning and concentrating tanks, add ethanol to alcohol content 60% (v/v), place, filter; Concentrate and be mixed to when relative density is 1.10 ~ 1.22 (90 DEG C of mensuration) and go out cream, in storage cream bucket, for subsequent use;
5) dry: wherein vacuum: 0.01MPa, temperature: 78 ~ 82 DEG C, 12 ~ 18 hours drying times;
6) powder is beaten: smashing fineness 80 mesh sieve, obtains clear paste powder;
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1 ~ 3:0.1 ~ 0.3 takes clear paste powder, dextrin and 55% ethanol, and wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%;
3rd step, drops in trough type mixing machine by clear paste powder and starch, stirs 20 minutes, slowly adds 55% ethanol while stirring, to making soft material, granulates with 12 order stainless steel sifts, and 60 ~ 70 DEG C of dryings 2 hours, take out, cool and obtain described granule.
Embodiment 4 clinical trial
The consumption of the Chinese medicine granules of the long Octopus ocellatus Gray Disease of skin fester of above-mentioned control is mix pharmaceutical chemistry in the ratio of 60g/100kg body weight, oral, and being used in conjunction 5 days is a course for the treatment of.Reached the object of disease therapy by intestinal absorption after oral.
On May 20th, 2013, the long Octopus ocellatus Gray morbidity that certain long Octopus ocellatus Gray raiser of area, Rongcheng, Shandong Province raises, clinical symptoms: ill long Octopus ocellatus Gray wrist, skin of trunk fester, and necrosis comes off, and severe patient festers and is deep into Musclar layer.Be typical ulcer disease after diagnosing.Then with Chinese medicine granules treatment described in the embodiment of the present invention 2, medication is after 2 days, and the state of an illness is clearly better, and obviously, mortality rate reduces by sky the change of health color, and after 5 days, mortality rate reduces to 0, is almost recovered.
Embodiment 4 clinical comparison is tested
On December 6th, 2013, the long Octopus ocellatus Gray morbidity that Rongcheng, Shandong Province long Octopus ocellatus Gray raiser raises is Disease of skin fester after diagnosing.The long Octopus ocellatus Gray of random choose 100 morbidity, is divided into two groups, often organizes 50.First group adopts Chinese medicine granules treatment described in the embodiment of the present invention 3, second group adopts the Chinese medicine granules treatment reducing part drug prescription, be made up of Radix Scutellariae, Radix Sophorae Flavescentis, Fructus Forsythiae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Herba Houttuyniae, Galla Chinensis, wherein, Radix Scutellariae 20kg, Radix Sophorae Flavescentis 18kg, Fructus Forsythiae 12kg, Rhizoma Polygoni Cuspidati 18kg, Radix Achyranthis Bidentatae 6kg, Herba Houttuyniae 11kg, Galla Chinensis 6kg.Process for preparing medicine is with embodiment 3.After first group of medication, long Octopus ocellatus Gray feed intake has no impact, and medication is after 2 days, and the state of an illness is clearly better, and mortality rate reduces by sky, and after 7 days, mortality rate is 0, is almost recovered.After second group of medication, the decline compared with first group of long Octopus ocellatus Gray feed intake, because feed intake declines, medicine Deficiency of Intake, DeGrain, after 5 days, cure rate is 46%.
No matter prevent and treat long Octopus ocellatus Gray Disease of skin fester with Chinese herbal and crude drugs preparations of the present invention, from the experimental results, be prevention, or treatment, evident in efficacy, but also do not produce drug resistance, if but change drug component, then affect the feed of long Octopus ocellatus Gray, reduce prevention and therapy effect.Apply through test of many times and small size, achieve good effect, remarkable in economical benefits.
Claims (6)
1. a raw material of Chinese medicine drug composition, it is characterized in that, described raw material of Chinese medicine drug composition includes the Chinese crude drug of following weight portion: Radix Scutellariae 16-20 part, Fructus Gardeniae 16-20 part, Radix Sophorae Flavescentis 12-18, Fructus Forsythiae 8-12 part, Fructus Gardeniae 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part, Radix Achyranthis Bidentatae 2-6 part, Herba Houttuyniae 8-11 part, Galla Chinensis 2-6 part.
2. raw material of Chinese medicine drug composition as claimed in claim 1, it is characterized in that, described raw material of Chinese medicine drug composition includes the Chinese crude drug of following weight portion: Radix Scutellariae 18 parts, Fructus Gardeniae 18 parts, Radix Sophorae Flavescentis 16, Fructus Forsythiae 10 parts, Fructus Gardeniae 16 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Achyranthis Bidentatae 4 parts, Herba Houttuyniae 9 parts, Galla Chinensis 4 parts.
3. the raw material of Chinese medicine drug composition described in claim 1 or 2 is for the preparation of Chinese medicine preparation.
4. be used for the treatment of or the Chinese medicine preparation of pre-minister of defense's Octopus ocellatus Gray Disease of skin fester, it is characterized in that, described Chinese medicine preparation is by being prepared by raw material of Chinese medicine drug composition by described in claim 1 or 2.
5. Chinese medicine preparation as claimed in claim 4, it is characterized in that, described Chinese medicine preparation is granule.
6. Chinese medicine preparation according to claim 5, its preparation method is as follows:
The first step, prepare clear paste powder:
1) get the raw materials ready: take the above-mentioned Chinese crude drug cleaned up by recipe quantity, pulverize, for subsequent use;
2) decoct: decoct with water, first decocts 8 times that every tank adds water as medical material total amount, and keep 2 hours after ebuillition of heated, extracting solution enters settling tank through 200 order metre filter; Second decocts the water heating extraction adding medical material amount 6 times, and protect and boil 1.5 hours, extracting solution enters settling tank through 200 order metre filter;
3) precipitate: in settling tank, extracting solution precipitates 12 hours, extract supernatant through 200 order metre filter in triple effect evaporator, precipitate is by offal treatment;
4) it is concentrated: when to be concentrated into relative density in triple effect evaporator be 1.05 ~ 1.10 (40 DEG C of mensuration) to supernatant, by rare clear paste in 200 order metre filter suction vacuum decompressioning and concentrating tanks, add ethanol to alcohol content 60%, place, filter; Concentrate and be mixed to when relative density is 1.10 ~ 1.22 (90 DEG C of mensuration) and go out cream, in storage cream bucket, for subsequent use;
5) dry: wherein vacuum: 0.01MPa, temperature: 78 ~ 82 DEG C, 12 ~ 18 hours drying times;
6) powder is beaten: smashing fineness 80 mesh sieve, obtains clear paste powder;
Second step, according to clear paste powder: starch: 55% ethanol is that the weight ratio of 1:1 ~ 3:0.1 ~ 0.3 takes clear paste powder, dextrin and 55% ethanol, and wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%;
3rd step, drops in trough type mixing machine by clear paste powder and starch, stirs 20 minutes, slowly adds 55% ethanol while stirring, to making soft material, granulates with 12 order stainless steel sifts, and 60 ~ 70 DEG C of dryings 2 hours, take out, cool and obtain described granule.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105288302A (en) * | 2015-11-27 | 2016-02-03 | 青岛海之源智能技术有限公司 | Feed additive for preventing and treating fester disease of Epinephelus akaara and preparation method of feed additive |
| CN106334017A (en) * | 2016-11-04 | 2017-01-18 | 威海虹润海洋科技有限公司 | Chinese herbal medicine preparation for preventing skin fester of offshore cage culture fugu rubripes |
| CN106334016A (en) * | 2016-11-04 | 2017-01-18 | 威海虹润海洋科技有限公司 | Chinese herbal medicine preparation for preventing skin fester of octopus ocellatus |
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| CN1131035A (en) * | 1995-12-05 | 1996-09-18 | 廖利平 | Chinese herbal medicine composition |
| CN1214242A (en) * | 1997-10-10 | 1999-04-21 | 罗萌 | Functional additive for bathing articles and its preparation |
| CN1375298A (en) * | 2001-01-04 | 2002-10-23 | 黄兆元 | Pain-relieving notoginseng mixture |
| CN1895471A (en) * | 2006-06-20 | 2007-01-17 | 王亚贤 | Chinese-medicinal jet embrocation for healing wound and its preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1131035A (en) * | 1995-12-05 | 1996-09-18 | 廖利平 | Chinese herbal medicine composition |
| CN1214242A (en) * | 1997-10-10 | 1999-04-21 | 罗萌 | Functional additive for bathing articles and its preparation |
| CN1375298A (en) * | 2001-01-04 | 2002-10-23 | 黄兆元 | Pain-relieving notoginseng mixture |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105288302A (en) * | 2015-11-27 | 2016-02-03 | 青岛海之源智能技术有限公司 | Feed additive for preventing and treating fester disease of Epinephelus akaara and preparation method of feed additive |
| CN106334017A (en) * | 2016-11-04 | 2017-01-18 | 威海虹润海洋科技有限公司 | Chinese herbal medicine preparation for preventing skin fester of offshore cage culture fugu rubripes |
| CN106334016A (en) * | 2016-11-04 | 2017-01-18 | 威海虹润海洋科技有限公司 | Chinese herbal medicine preparation for preventing skin fester of octopus ocellatus |
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| CN104971132B (en) | 2018-12-28 |
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